ライフサイエンスコーパス: directed

1 The MTS of BCO2a directed a green fluorescent reporter protein to the mit

2 Each stress directed a highly specific pattern of change, which refl

3 These mediators exert potent leukocyte directed actions and control vascular inflammation.

4 Understanding object-directed actions performed by others is central to every

5 ation of addiction, related to impaired goal-directed actions, as well as countervailing resilience s

6 We find further that the phosphoinositide-directed activities of both PIKfyve and Fig4 are regulat

7 th PIKfyve and Fig4 are regulated by protein-directed activities within the complex.

8 EventMine that extracts multiple overlapping directed acyclic graph structures from a raw sentence.

9 Meanwhile, a directed acyclic network of emerging phenomena is compos

10 PFQX in conjunction with ligand-directed acyl imidazole chemistry enables covalent label

11 ction model, suggesting its utility for host directed adjunct therapy.

12 bation of platelets with a blocking antibody directed against CD36 or with a pharmacologic inhibitor

13 ions, redosing or combination of CAR T cells directed against different targets, and decreased cost u

14 potential for new therapeutic interventions, directed against evolving resistance.

15 IP(3)R knockdown with short-interfering RNA directed against IP(3)R1.

16 of thymic selection on the T-cell repertoire directed against MiHA can be studied in both self (MiHAp

17 volocumab, a fully human monoclonal antibody directed against proprotein convertase subtilisin-kexin

18 Application of an antibody, directed against the CD147-Ig1 domain, displaces CAIX fr

19 the receptor-binding domain (RBD) and those directed against the N-terminal domain (NTD), indicating

20 es in the NOD mouse model of T1D produce Abs directed against the neuronal type III intermediate fila

21 oantibodies in serum and cerebrospinal fluid directed against the nuclei of Purkinje cells, striatal

22 dies was about equally divided between those directed against the receptor-binding domain (RBD) and t

23 d a new strategy using proteins as structure-directed agents to direct the formation of new ZMOFs tha

24 te tumor DDR function and sensitivity to DDR-directed agents, we created a series of ATM-deficient pr

25 g-term depression that requires G(betagamma)-directed Akt-GSK3beta signaling.

26 n targeting the intrinsic regulation of goal-directed alertness in patients with chronic hemispatial

27 ssion events associated with Chr1- and Chr10-directed AMD.

28 Effect-directed analysis (EDA) was applied for the identificati

29 proach precision medicine, allowing for more directed and efficient management of CR-POPF.

30 distinction is made between voluntary (goal-directed) and involuntary (stimulus-driven) guidance of

31 and 18 healthy controls performed fast goal-directed ankle dorsiflexion contractions aiming at a spa

32 ed long-term potentiation induction, and LRR-directed antibodies with higher binding strengths induce

33 Precise targeting of stem-directed antibody responses to the site of vulnerability

34 ws the data on the factor XII- and factor XI-directed anticoagulants under development, describes nov

35 g margin mechanosensory bristles undergo PCP-directed apical rotation, inducing twisting that results

36 t to utilize pediatric models to inform cure-directed approaches for HIV-1-infected children.

37 Template-directed assembly has been shown to yield a broad divers

38 brication and manipulation followed by light-directed assembly of MoS(2) nanoribbons, and their uniqu

39 an aqueous suspension enabled the successful directed assembly of nanocapsules using a reversible add

40 E, esIgD, esIgG(1) , and esIgG(4) antibodies directed at 58 (15-mer) overlapping peptides, covering t

41 helper type 2 (T(H)2)-skewed immune response directed at bladder re-epithelialization is observed, wi

42 We further suggest that interventions directed at boosting the peripheral immune response can

43 duces strong inflammatory responses that are directed at clearing the infection, but if not controlle

44 Further studies may be directed at determining whether its use in conjunction w

45 to have optimum translational interventions directed at reactivation due to co-infection.

46 unmet need to develop mechanistic treatments directed at root causes of AF.

47 Immunotherapy directed at the PD-L1/PD-1 axis has produced treatment a

48 Moreover, this work opens the way to studies directed at understanding the roles of O-GlcNAc and othe

49 promoted USV(+) mounting, and converted male-directed attack to mounting with USVs.

50 have been extracted, the engagement of goal-directed attention is key to enable rule generalization.

51 Goal-directed attention is usually studied by providing indiv

52 TnI-directed autoimmune myocarditis (TnI-AM), a CD4(+) T-cel

53 Goal-directed behavior can benefit from proactive adjustments

54 Such goal-directed behavior involves evolutionary conserved brain

55 Goal-directed behavior requires the interaction of multiple b

56 o it can be processed in the support of goal-directed behavior.

57 task-irrelevant stimuli is critical for goal-directed behavior.

58 Silencing glutamate favored goal-directed behaviors and had no impact on eating behavior.

59 set of cognitive functions that support goal-directed behaviors.

60 We first demonstrate that learning via goal-directed behaviour indeed constrains models to behaviora

61 s is to learn online in the presence of goal-directed behaviours.

62 eutrophil differentiation and the eosinophil-directed bias of murine bone marrow stem cells, demonstr

63 ith retained affinity for VRC01-class, CD4bs-directed bNAbs and dampened affinity for nonneutralizing

64 le of catalytic 1,2-diarylation of an alkene directed by a native carboxylate group.

65 ations requires intentional synthetic design directed by fundamental chemical principles.

66 Embryogenesis is directed by morphogens that induce differentiation withi

67 ionally been viewed as an autonomous process directed by the host genome.

68 ges indicate that the branching patterns are directed by the seed defects, with the emergence of bran

69 use of peroxides in C-H activation reactions directed by weakly coordinating native functional groups

70 The recent development of phosphine-directed C-H borylation of arenes has now been extended

71 lectivity represents a key challenge for non-directed C-H functionalization, even when the C-H bond i

72 they are an appealing conceptual target, CSC-directed cancer therapies remain scarce.

73 elated to the breakdown of the last relevant directed catalytic cycle within a dynamical system.

74 Directed cell growth or migration are critical for the d

75 y, and this activity is required in vivo for directed cell migration and for maintaining normal level

76 Manipulating these parameters directed cells in mathematically predictable ways; speci

77 ies, many patients may not receive guideline-directed cephalosporin-based prophylaxis, which may resu

78 livers up-regulated expression of the B cell-directed chemokine (C-C motif) ligand 5.

79 Drug addiction may be a goal-directed choice driven by excessive drug value in negati

80 Control networks are thought to support goal-directed cognition and behavior.

81 g the molecular mechanisms that underlie RNA-directed complex assembly.

82 ay better temporal accuracy during fast goal directed contractions.

83 A weakly coordinating carbonyl-directed coupling of allyl alcohols at the C-4 position

84 In both current main approaches-tether-directed covalent functionalization and supramolecular m

85 Directed crystal growth on designer substrates has the p

86 Either genetically directed deletion or acute optogenetic silencing of DR(S

87 Here, we report the directed differentiation of human iPSCs into airway basa

88 Here, we report a directed differentiation protocol for the generation of

89 luripotent stem cells (hPSCs) are subject to directed differentiation through a paraxial mesoderm pro

90 We find evidence of goal-directed dimensionality reduction within human ventromed

91 een substance used and the outcomes: patient-directed discharge (PDD, or "against medical advice") an

92 all interfering RNAs (siRNAs) that guide RNA-directed DNA methylation.

93 sorders, the molecular contributions to goal-directed dysfunction remain unclear.

94 d as hierarchical directed graphs, where the directed edges indicate influence.

95 tworks where nodes represent STM strains and directed edges represent evolutionary steps, presenting

96 Rapid and directed electron transfer (ET) is essential for biologi

97 Previous provider-directed electronic messaging interventions have not by

98 these data suggest that DDI2 is a ubiquitin-directed endoprotease.

99 ew, we summarize recent advances in uHTS for directed enzyme evolution.

100 ults (mean age, 21.7 years) performed a goal-directed episodic encoding and retrieval task(22).

101 ET94 (PpDyP) and three variants generated by directed evolution (DE) are studied aiming at the design

102 Here, using a directed evolution approach with our two previously desc

103 port in brain, was generated in mice using a directed evolution approach.

104 Advances in directed evolution have led to an exploration of new and

105 Directed evolution of a serine-ligated P450 variant, P41

106 ficial phylogeny emerging in three rounds of directed evolution of an amine dehydrogenase biocatalyst

107 Mix Library on Beads-was applied towards the directed evolution of an anti-IgE Affibody (ZIgE), gener

108 zed bead labelling and demonstrate it by the directed evolution of efficient RTs for 2'-O-methyl RNA

109 Directed evolution of genetically encoded cytochrome P41

110 ways, by changing its population size and by directed evolution of new functions.

111 Directed evolution of PLD using yeast membrane display a

112 ped a generalizable yeast-based platform for directed evolution of protease catalytic properties.

113 Here we describe a general strategy for the directed evolution of RT function for any template chemi

114 Using this assay as a directed evolution screen, we demonstrate the generation

115 spect that is often overlooked in laboratory directed evolution studies.

116 GlcNAc(2)GlcN(2), sufficed to identify, in a directed evolution, the site-saturation mutagenesis libr

117 Using directed evolution, we engineered a 'decoy-resistant' IL

118 cipants showed reduced levels of uncertainty-directed exploration and increased levels of random expl

119 Modeling revealed attenuated directed exploration under L-dopa, while neural signatur

120 two strategies of explore-exploit behavior: directed exploration, where information drives explorati

121 t rostrolateral prefrontal cortex and drives directed exploration, while total uncertainty is represe

122 correlation between temporal discounting and directed exploration, with more temporal discounting lea

123 th more temporal discounting leading to less directed exploration.

124 egimens for ultrasound-facilitated, catheter-directed fibrinolysis improve short-term computed tomogr

125 egimens for ultrasound-facilitated, catheter-directed fibrinolysis in the OPTALYSE-PE trial (Optimum

126 Catheter-directed fibrinolysis with or without mechanical thrombe

127 with NLPHL who had received Hodgkin lymphoma-directed first-line treatment in randomized GHSG trial p

128 inds, and as wind speeds increased, to be in directed flight rather than ARS.

129 were used to characterize behavioural states-directed flight, area-restricted search (ARS) and restin

130 g the hypothesis that adoption of internally-directed focused attention, indexed by increased alpha a

131 ficient method, i.e. the excessive-reductant-directed gelation strategy.

132 our widely-applicable approach for inferring directed genotype networks from data, but also provide a

133 cs on organisations modelled as hierarchical directed graphs, where the directed edges indicate influ

134 naling modulates the cytoskeleton to produce directed growth cone motility.

135 e a general definition of Ricci curvature on directed hypergraphs and explore the consequences of tha

136 This can complement existing T cell-directed immunotherapy, providing a promising approach t

137 eutic approaches, an issue that becomes more directed in this evolving era of precision medicine.

138 Site directed incorporation of Cu2+-chelated to a ligand, 2,2

139 products, buildings, and infrastructures has directed increasing attention to urban mining and circul

140 We show that stimulus-driven and goal-directed influences compete for selection in memory, and

141 the substrate-binding site by an active site-directed inhibitor.

142 Transposon directed insertion-site sequencing (TraDIS) is a powerfu

143 orme (GBM) in late-phase clinical trials has directed interest toward adoptive cellular therapies (AC

144 on the PP scaffold included 2-pyridyl ethers directed into the hydrophobic pocket and small carbocycl

145 Here, we present a selective maleylation-directed isobaric peptide termini labeling (SMD-IPTL) ap

146 In contrast, although initial goal-directed learning was unaffected by iSPN manipulations,

147 that is necessary for updating previous goal-directed learning.

148 We show that template-directed ligation can assemble long RNAs from shorter ol

149 Subsequent systemic and liver-directed locoregional therapies ameliorated survival, hi

150 contrast to the LRR-directed mAbs, the EPTP-directed mAbs showed far less avid binding to brain tiss

151 campal injection, and by contrast to the LRR-directed mAbs, the EPTP-directed mAbs showed far less av

152 and enhanced the type 1 immune response that directed macrophage polarization toward M1 macrophages.

153 nt-of-package warning labels, restrict child-directed marketing, and ban sales in schools of all food

154 Second, event-related directed medial prefrontal cortex to basal ganglia effec

155 th UMI were less likely to receive guideline-directed medical therapies and presented an increased ri

156 hat, in the modern era of improved guideline-directed medical therapies, imaging of myocardial viabil

157 ed to TMVr with the MitraClip plus guideline-directed medical therapy (GDMT) (n = 302) versus GDMT al

158 ir (TMVr) using the MitraClip plus guideline-directed medical therapy (GDMT) reduced 2-year rates of

159 bable vascular scaffold (BVS) plus guideline-directed medical therapy (GDMT) versus GDMT alone.

160 e symptomatic HFrEF taking optimal guideline-directed medical therapy and with a cardiac implantable

161 Guideline-directed medical therapy, surgical mitral valve repair o

162 We reported the EF-directed migration of both rat Schwann cells (SCs) and o

163 -) zebrafish larvae have impaired neutrophil directed migration to tail wounds with an initial lag in

164 ss, has been proposed as a mechanism driving directed migration.

165 cs of biomolecules without the need for site-directed modifications or bio-orthogonal labels.

166 We posit that dopamine promotes goal-directed motivation, but dampens reward-driven vigour, c

167 F13B undergoes a tug-of-war with a minus-end directed motor.

168 onal behavioural data suggest that most male-directed mounting is aggressive, although in rare cases

169 eneral principles that govern controlled and directed movement at the molecular scale, we describe th

170 e expression, but the mechanisms behind this directed movement have remained uncertain.

171 t for various phenomena observed during goal-directed movements.

172 reasons behind the development of GSK-3beta-directed MTDLs and highlight some of the recent efforts

173 2 intermediates and iterative rounds of site-directed mutagenesis allowed us to identify 4 of 413 res

174 Kinetic, molecular docking, and site-directed mutagenesis analyses confirmed these compounds

175 Using site-directed mutagenesis and a specific in vitro transcripti

176 Results from site-directed mutagenesis and competitive ligand-binding anal

177 cco (Nicotiana tabacum L.) using CRISPR site-directed mutagenesis and overexpression assays.

178 reinhardtii (CrHydA1) we have conducted site-directed mutagenesis and protein film electrochemistry t

179 We used site-directed mutagenesis and single-cell patch-clamp to anal

180 Site-directed mutagenesis and structural modeling analyses di

181 hippocampus, together with an in vitro site-directed mutagenesis approach, we identify loss of STAT3

182 Site-directed mutagenesis of both cofilin and actin revealed

183 ture and function of CHT7, we performed site-directed mutagenesis of previously identified phosphoryl

184 findings is validated experimentally by site-directed mutagenesis of the key CcmK2 residue Serine 39.

185 ct the activity of G. lovleyi NrfA, and site-directed mutagenesis of this arginine reduced enzymatic

186 Past studies, based on site-directed mutagenesis or solvatochromism of the isolated

187 Site-directed mutagenesis showed that the relevant sites for

188 bauer spectroscopy measurements and the site-directed mutagenesis studies show that the red Fur prote

189 type fructooligosaccharide and utilized site-directed mutagenesis to identify residues involved in su

190 Using site-directed mutagenesis to test multiple potential sites of

191 Site-directed mutagenesis was used to create orthogonal MTs p

192 nteractions to validation using data on site-directed mutagenesis' effect on capsid assembly.

193 with the help of isotopic labeling and site-directed mutagenesis, and complemented by integration an

194 assays, sugar binding pocket deletions, site-directed mutagenesis, and construction of chimeric enzym

195 used the chemical modification of Trp9, site-directed mutagenesis, and crystallographic and computati

196 ology protein modeling, ligand docking, site-directed mutagenesis, and electrophysiology, we show tha

197 Using site-directed mutagenesis, surface plasmon resonance, and cry

198 Using site-directed mutagenesis, we demonstrate that the M159I subs

199 In addition, using site-directed mutagenesis, we identify those amino acids that

200 re-function relationship of (Pl)EctA by site-directed mutagenesis.

201 n transfer difference NMR (STD-NMR) and site-directed mutagenesis.

202 in E coli supports efficient multiplex site-directed mutagenesis.

203 e determinants were resolved further by site-directed mutagenesis.

204 ies form a "we," and arguing that it grounds directed obligations and rights.

205 Enormous internal turgor pressure is directed onto a penetration peg emerging from the unmela

206 Phosphonate-directed ortho C-H borylation of aromatic phosphonates i

207 osphodegrons to empower an N-to-C terminally directed phosphorylation process.

208 driven by local membrane protrusion through directed polymerization of F-actin at the front.

209 to naturally exhibit long-distance minus-end-directed processive motility on single microtubules as i

210 cer treated with anthracyclines and/or chest-directed radiation are at increased risk for heart failu

211 We integrated multiomics data to construct directed regulatory networks with nodes and edges labele

212 ange of transition-metal-catalyzed, template-directed remote C-H activation reactions of alcohols, ca

213 disruption or gene modification via homology directed repair (HDR) from donor DNA.

214 lso find that RNF8 is important for homology-directed repair (HDR) independently of KU, which appears

215 ow that inhibition of PARG disrupts homology-directed repair (HDR) mechanisms that underpin alternati

216 genous DNA or gene knock-in via the homology-directed repair (HDR) pathway has seldom been achieved o

217 es (tCTSs) added at the ends of the homology-directed repair (HDR) template interact with Cas9 ribonu

218 -CRISPR associated protein 9 (Cas9) homology directed repair (HDR) to create isogenic lines that vari

219 or template into embryos to trigger homology directed repair (HDR).

220 To improve Cas9's homology directed repair capacity, here we report the development

221 an additional introgression of the homology-directed repair donor plasmid along with the P(C) Celtic

222 Meiotic crossovers result from homology-directed repair of DNA double-strand breaks (DSBs).

223 alization of DNA damage factors and homology directed repair of dysfunctional telomeres lacking POT1-

224 ced double strand breaks repair via homology-directed repair pathway and prostate tumorigenesis.

225 e non-homologous end joining or the homology directed repair pathways.

226 addition of telomeric repeats with homology-directed repair serving as a back-up mechanism.

227 contrast to traditional CRISPR-Cas9 homology-directed repair, base editing can correct point mutation

228 e CD8(+) T cells using CRISPR-based homology-directed repair.

229 balance between indel formation and homology-directed repair.

230 The mouse SAN enhancer also directed reporter activity to the inflow tract in develo

231 ses confirmed these compounds as active site-directed reversible inhibitors of mPTPB.

232 orsomedial striatum (DMS) in regulating goal-directed reward-seeking behavior has been long appreciat

233 d facilitates shifting from habitual to goal-directed reward-seeking behavior.

234 mbers that developed either habitual or goal-directed reward-seeking behaviors.

235 ARs are also important in the development of directed RNA editing therapeutics.

236 Silencing expression of RNA-directed RNA polymerases RdR1 and RdR2 (but not RdR3) an

237 Directed self-assembly of block copolymers (BCPs) enable

238 osphoinositide metabolism and inhibits MyD88-directed signal transduction.

239 ion in Caenorhabditis elegans activates RNAi-directed silencing via induction of a pathway homologous

240 orylation of S319 and possibly other proline-directed sites and retention of Y359 and S362 phosphoryl

241 The vast majority of therapeutics are directed solely at neurons, despite the fact that signal

242 vered that the normal invigoration of female-directed song was also accompanied by increased HVC acti

243 r by using atomic-level simulations and site-directed spectroscopy to reveal the effects of phosphory

244 Site-directed spin labeling (SDSL) ESR is a valuable tool to

245 Site directed spin labeling EPR and DEER (double electron-ele

246 ether with STAM1 activates FAK, we used site-directed spin-labeling EPR spectroscopy-based studies co

247 bled to homogeneity and investigated by site-directed spin-labeling with pulse-dipolar electron-spin

248 on and metastatic growth by repressing MBNL1-directed splicing of ITGA6 Our findings also indicate th

249 etween allosteric cooperativity and template-directed synthesis has been investigated by studying com

250 Template-directed synthesis has been used to prepare a fully pai-

251 and provide computational methods to design directed synthesis routes for diverse self-assemblies an

252 ng glycolysis are potential targets for host-directed TB control.

253 piRNA biogenesis but is essential for piRNA-directed TE de novo methylation and silencing.

254 logy and therapeutic rationale behind B-cell-directed therapeutics in MS, and proposes strategies to

255 ly, and facilitate development of microbiota-directed therapeutics.

256 Anti-interleukin-6-directed therapies are highly effective in many iMCD pat

257 d with local cytoreductive and/or metastasis-directed therapies.

258 xplain the limited success of previous brain-directed therapies.

259 h and wait"), while 61% had received >=1 CLL-directed therapy (median, 2; range, 1-8).

260 on how to best implement MRD testing and MRD-directed therapy after allo-HCT are lacking.

261 support targeting S100A8/A9 pathways as host-directed therapy for TB.

262 valuation of pravastatin as adjunctive, host-directed therapy for TB.

263 able precision medicine application of NOTCH-directed therapy in CCA as well as prospectively across

264 alignancy, defined as those receiving cancer-directed therapy or under active surveillance within 6 m

265 o the perspective of finding a reliable host-directed therapy to reduce disease burden.

266 cytoreductive strategy, including metastasis-directed therapy, in the current era of sequential multi

267 and major bleeding within 72 hours after BEC directed therapy.

268 osis and potentially enabling prompt disease-directed therapy.

269 tes MYC at serine 67, counteracting GSK3beta-directed threonine 58 phosphorylation and subsequent FBX

270 arameters among patients undergoing catheter-directed thrombolysis for submassive or massive pulmonar

271 ports in the infected provinces in China and directed to Africa to estimate the risk of importation p

272 Future work will be directed to define how these properties enable KIF3AC to

273 rt, positive traditional FXM results are not directed to donor HLA 60.25% of the time and negative tr

274 Of note, antibodies directed to epitopes overlapping with those of non-NAbs

275 and Shuker introduce animal sexual behaviors directed to members of the same sex.

276 We report here that ANKS4B is directed to the brush border using a noncanonical apical

277 ion criterion selectively when attention was directed to the contralateral visual field.

278 elongate over several cell diameters and are directed to the correct muscle attachment sites.

279 mized, and public health resources should be directed to those with preexisting medical conditions, t

280 and the second reverses the typical outward-directed topology of the sheath electric field into a fo

281 While much attention has been directed toward adult sex hormones as drivers of sex dif

282 rogram that led to vaborbactam, efforts were directed toward expanding the spectrum to allow treatmen

283 ed animals walked faster when their gaze was directed toward home, and this behavior was eliminated b

284 self-management support resources should be directed toward patients with such risk factors for poor

285 opic nature, the reader will be specifically directed toward various inborn errors of metabolism whic

286 upon the workup choices, the process can be directed towards either tin- or iodo-substituted product

287 and/or the performance of EUS in 6-12 months directed towards lesions determined to be low risk (by a

288 , in recent years research efforts have been directed towards modeling the structure and dynamics of

289 ing and learning songs; however, song is not directed towards other individuals and has no obvious, i

290 Pharmacologic and probiotic approaches directed towards specific TLR2 signaling processes might

291 gnaling cascades are activated, many of them directed towards the tumor suppressor p53, which coordin

292 cally plausible, and increasing attention is directed towards thrombotic microembolism as the underly

293 These teleconnections generate oppositely directed trade-wind anomalies in the Central and Eastern

294 on within-host viral diversity to construct directed transmission networks.

295 the primary motor for microtubule minus-end-directed transport and is indispensable to eukaryotic ce

296 of speech; 2) a longer distance, ~1 m, where directed transport is driven by individual vortical puff

297 emonstrated that during microtubule plus-end directed transport, both kinesins localize to the vesicl

298 esults of positron emission tomography (PET)-directed treatment approaches, we designed a National Cl

299 d theoretical investigation of more powerful directed types of synaptic plasticity.

300 excitability: the annihilation of oppositely directed waves, all-or-none responsiveness, and refracto