ライフサイエンスコーパス: disable

1 (CA) coma are expected to remain permanently disabled.

2 lethality when RIPK3-mediated necroptosis is disabled.

3 d not undergo necroptosis, even when MK2 was disabled.

4 territory unless their pheromone-sensing is disabled.

5 Tachyarrhythmia functions were disabled.

6 globulin, but some respond poorly and remain disabled.

7 an expected, and symptoms are persistent and disabling.

8 Anxiety disorders are common and often disabling.

9 Disabled-2 (Dab2) is a multifunctional scaffold protein

10 Disabled-2 (Dab2) is an adaptor protein that regulates t

11 ST progressively disabled a host mechanism of protection by inducing endo

12 p in starch synthesis, and the suc2 mutation disables a sucrose/proton symporter that facilitates suc

13 ploids, each carrying a different gene drive disabling a gene of interest, we are able to create dipl

14 When mitochondrial fission is disabled, AC-induced increase in cytosolic calcium is bl

15 eased with increasing VPD, consistent with a disabled active response of guard cell osmotic pressure.

16 I, 0.57-0.85] for women) and from healthy to disabled (adjusted HR, 0.52 [95% CI, 0.44-0.61] for men

17 ing genes, and 169 pseudogenes, most of them disabled after primates diverged.

18 showed that peptidoglycan recycling blockade disables AmpC-dependent resistance and enhances suscepti

19 causes an important virulence impairment and disables AmpC-mediated resistance, being hence validated

20 Thus, loss of Krit1 function disables an angiogenic checkpoint to enable CCM formatio

21 and prevents repair of the FRC network, thus disabling an essential platform for purging autoreactive

22 By disabling an inhibitory circuit impacting PD1 and TRAIL,

23 he model estimates disability prevalence and disabled and disability-free life expectancy by year.

24 The model with 2 classes, disabled and nondisabled, had the best fit with an entro

25 e time of pain onset were significantly more disabled and suffered more pain.

26 e use of rapamycin for the treatment of this disabling and deadly disease.

27 They are typically progressive, very disabling and frequently involve the nervous system.

28 eonatal brachial plexus injury (NBPI) causes disabling and incurable contractures, or limb stiffness,

29 athogenic factor for a large group of highly disabling and life-threatening human diseases, such as n

30 and ischemic) or of any functional severity (disabling and nondisabling) is predictive of a poor 2-ye

31 Psychotic depression is a severely disabling and potentially lethal disorder.

32 lth transitions (healthy to dead, healthy to disabled, and disabled to dead).

33 ed, often had delirium, were very physically disabled, and many were approaching the end of life.

34 e, 57+/-9% for ischemic stroke, 51+/-11% for disabling, and 51+/-11% for nondisabling compared with 8

35 g mental health are highly prevalent, can be disabling, and are associated with substantial premature

36 tor and sensory abnormalities are prevalent, disabling, and intertwined with emotional and cognitive

37 ty and fear-related disorders are common and disabling, and they significantly increase risk for suic

38 or in the absence of danger is a hallmark of disabling anxiety disorders that affect millions of peop

39 COM1 gene of Colletotrichum gloeosporioides disables appressorial differentiation and effectively pr

40 One significant pathway that is disabled as a result is homologous recombination repair

41 lin-associated glycoprotein) neuropathy is a disabling autoimmune peripheral neuropathy caused by mon

42 Although disabling autophagy did not impact replication of an ICP

43 6 (28%) glaucoma patients were classified as disabled based on NEI VFQ-25 results, whereas 169 (72%)

44 ial throat will significantly assist for the disabled, because the simple throat vibrations such as h

45 tivation of the two binding sites completely disabled binding of RD3 to RetGC1 in living HEK293 cells

46 luding minor, major, and life-threatening or disabling bleeding) and non-procedure-related bleeding o

47 sening atrial fibrillation, life-threatening/disabling bleeding, and acute kidney injury stage 2/3 we

48 cause death, any stroke, life-threatening or disabling bleeding, major vascular complications, corona

49 ntaining M2-to-M1 repolarization signals can disable both mechanisms.

50 -coated magnetic nanoparticles (gCM-MNs) can disable both mechanisms.

51 Brain lesions do not just disable but also disconnect brain areas, which once depr

52 Drug-induced movement disorders are disabling but are often under-recognised and inappropria

53 This effect is disabled by a Vpr mutation that abolishes binding to CRL

54 Others only sporulate, but if sporulation is disabled by heterozygosity at the IME1 locus, those dipl

55 gth of fearful memories could benefit people disabled by memories of past trauma.

56 he JAK/STAT signaling pathways, which can be disabled by small molecules.METHODSWe treated a group of

57 How these inhibitors disable Cas12a by preventing programmed DNA cleavage is

58 (Clopidogrel in High-Risk Patients With Non-disabling Cerebrovascular Events), a similar trial treat

59 tion of Orai1 channels in inhibitory neurons disables chemoconvulsant-induced excitation of GABAergic

60 ncreases in a male, myopic, and intellectual disabled child.

61 terventions can also delay the onset of many disabling, chronic diseases, including cancer, cardiovas

62 t IL-6 trans-signaling fully compensates for disabled classic signaling in liver regeneration after P

63 o occur in 37.5%, and 2 persons had a severe disabling clinical course.

64 llness frequently experience significant and disabling cognitive and affective disorders.

65 Dementia or disabling cognitive impairment was predicted with an AUC

66 Executive dysfunction is a common and disabling component of late-life depression (LLD), yet i

67 tic and therapeutic challenge and is often a disabling condition for patients.

68 children and adolescents is a recurrent and disabling condition globally but its pathophysiology rem

69 ate-life depression (LLD) is a prevalent and disabling condition in older adults that is often accomp

70 Carpal tunnel syndrome (CTS) is a common and disabling condition of the hand caused by entrapment of

71 CSCR is a common visually disabling condition that develops in individuals up to 6

72 e-compulsive disorder (OCD) is a chronic and disabling condition that often responds unsatisfactorily

73 Obsessive-compulsive disorder (OCD) is a disabling condition, often associated with a chronic cou

74 red to reduce the burden of the world's most disabling condition.

75 t to developing targeted treatments for this disabling condition.

76 as one of the major contributors of nonfatal disabling conditions.

77 roach for individuals suffering from chronic disabling conditions.

78 tment, thereby avoiding its life-threatening/disabling consequences.

79 ve limb-girdle weakness with rigid spine and disabling contractures.

80 thyroid-associated orbitopathy, is visually disabling, cosmetically disfiguring and has a substantia

81 otocol and the use of compact prefilled auto-disable (CPAD) devices for community births.

82 Eating disorders are disabling, deadly, and costly mental disorders that cons

83 Multiple sclerosis (MS) is a disabling disease of the CNS.

84 be a valid treatment option in this rare and disabling disease.

85 Migraine is one of the most prevalent and disabling diseases worldwide, but until recently, few mi

86 neurological disorder (FND) is a common and disabling disorder that is often considered difficult to

87 ogical disorder (FND) is a common and highly disabling disorder, but its aetiology remains enigmatic.

88 ss disorder (PTSD) is a prevalent and highly disabling disorder, but there is currently no targeted p

89 Migraine is a prevalent and disabling disorder.

90 population, and is ranked in the top 20 most disabling disorders due to its high level of disability.

91 K1 directly phosphorylated DRP1/DNM1L, which disabled DRP1, preventing its high-order oligomerization

92 ion-targeting agents offer new approaches to disable drug resistance in B-cell lymphomas.

93 efibrillator (ICD) had tachycardia therapies disabled during the MRI.

94 encoding could help clinicians identify and disable electrodes that evoke poor neural responses so a

95 tiation, FGF4 utilises a bimodal strategy to disable EPHA2, which is accompanied by transcriptional i

96 Triple deletion of Etv5, Rbpj, and Tcf3 disables ESCs, such that they remain largely undifferent

97 Hand amputation is a highly disabling event, which significantly affects quality of

98 The discovery of mutations that partially disable exocyst function provides valuable insight into

99 ly rising global health crisis that silently disables families and ends lives and livelihoods around

100 Of the 597 disabling/fatal incident ischaemic strokes, 369 occurred

101 However, differences in hemorrhagic stroke, disabling/fatal stroke, cardiovascular/unexplained death

102 A third of all disabling/fatal strokes occur in non-anticoagulated pati

103 sociated degradation pathway through US11 to disable FcRn functions.

104 Cognitive impairments are a particularly disabling feature of major depressive disorder.

105 It is an increasingly common and disabling fibroproliferative disorder of the palmar fasc

106 12 weeks to induce PVC-CM in 7 animals then disabled for 4 weeks to allow complete recovery of left

107 The K120R mutation renders the p53 protein disabled for acetylation and, as a result, defective for

108 Cranial nerve injury is disabling for patients, and facial nerve injury is parti

109 Chronic cluster headache is the most disabling form of cluster headache.

110 age (ICH) is one of the most devastating and disabling forms of stroke, yet effective treatments are

111 Studies on high-risk populations (e.g., disabled) found improvements in quality specific to a st

112 d using a claims-based algorithm: nonelderly disabled, frail elderly, major complex chronic, minor co

113 fices to keep the gate of C1C2 closed and to disable free water and ion passage through the putative

114 umber of people affected by, or who remained disabled from, stroke has increased across the globe in

115 scious intention, leading to maladaptive and disabling gait abnormalities.

116 The disabled group had 48 (18%) patients, whereas 215 (82%)

117 The average MD of the better eye in the disabled group was -5.98 dB vs -2.51 dB in the nondisabl

118 A cabinet in the room contained a real (disabled) gun with a sensor counting trigger pulls.

119 BARD1 ankyrin repeat domain mutations disabling H4K20me0 recognition abrogate accumulation of

120 Goblet cell metaplasia, a disabling hallmark of chronic lung disease, lacks curati

121 tion; a third of individuals are affected by disabling hearing loss by the age of 65.

122 Disabling hearing loss impacts ~466 million individuals

123 ver 360 million people worldwide suffer from disabling hearing loss.

124 monstrate that in OCSC, the tumor suppressor disabled homolog 2-interacting protein (DAB2IP) is silen

125 ion at least once during the course of their disabling illness or injury.

126 lized anxiety disorder (GAD) is a common and disabling illness that is often underdiagnosed and under

127 Millions more people have severe disabling illnesses, cancers, and disabilities stemming

128 immunological control of the disease despite disabled immunosurveillance.

129 The tetrazine form is disabled in terms of light-induced cargo release, howeve

130 Proteins disabled in the cancer-prone disorder Fanconi anemia (FA

131 ating lymphocytes that had been functionally disabled in the human renal cell carcinoma environment w

132 a reversible commitment requiring initially disabling indoor chulhas.

133 A disabled infectious single-cycle (DISC) GPCMV vaccine st

134 A disabled infectious single-cycle (DISC) viral vaccine st

135 studies, we generated replication-deficient (disabled infectious single-cycle [DISC]) virus strains f

136 patients were aged 18 years or older with a disabling ischaemic stroke at the time of randomisation,

137 ) is standard of care in patients with acute disabling ischemic stroke attributable to large-vessel o

138 s the PALB2-BRCA1 interaction and completely disables its abilities to promote HR and confer resistan

139 STYX binds to the F-box domain of FBXW7 and disables its recruitment into the SCF complex.

140 nd in intrahepatic cholangiocarcinoma (ICC), disables its role in enhancing TGF-beta signaling and ab

141 n-preventable and often kills or permanently disables its victims.

142 l in which we inactivated Cic by selectively disabling its DNA-binding activity, a mutation that caus

143 eleted and lacY is retained, was employed to disable lactose consumption.

144 had a higher cumulative incidence of severe, disabling, life-threatening, and fatal chronic health co

145 oth at greater risk of developing severe and disabling, life-threatening, or fatal (grade 3-5) health

146 interaction of MICU1/2 with the MCU complex disables matrix Ca(2+) regulation of channel activity.

147 on managing long-term care among elderly and disabled Medicaid recipients.

148 several tissues of gene-edited organogenesis-disabled mice.

149 bone marrow-derived ALD-401 in patients with disabling middle cerebral artery stroke in comparison wi

150 ent assessed with the modified Rankin Scale (disabling [modified Rankin Scale score >3] versus nondis

151 NCE STATEMENT Dystonia is a common and often disabling movement disorder.

152 ary muscle co-contractions that give rise to disabling movements and postures.

153 could work in concert with host immunity to disable Mtb.

154 mutant virus in which formation of PtDd was disabled (mut-Ad3GFP, where GFP is green fluorescent pro

155 y neutrophil disorders typically result from disabling mutations of individual genes that result in i

156 in catalytic activity due to the presence of disabling mutations.

157 Among the disabled (n=21,595), sleeve was associated with lower 3-

158 Disabling native regulation can turn on nitrogenase expr

159 that the GluN2A(N615K) variant underlies the disabling neurodevelopmental phenotype in carriers.

160 Episodic cluster headache is a disabling neurologic disorder that is characterized by d

161 of multiple sclerosis (MS), the most common disabling neurological disease in young adults.

162 Chronic non-freezing cold injury is a disabling neuropathic pain disorder due to a sensory neu

163 a leading cause of lower-limb amputation and disabling neuropathic pain.

164 a length-dependent distribution resulting in disabling neuropathic pain.

165 rtance of early intervention efforts in this disabling neuropsychiatric syndrome.

166 (52%) developed refractory heart failure to disabling New York Heart Association functional classes

167 on of noradrenergic neurons may underlie the disabling nonmotor symptoms in patients with Parkinson d

168 sing a conditional mouse genetic approach to disable nonredundant subunits of mTORC1, mTORC2, or both

169 ntial for growth and metabolism and that the disabling of both pathways is likely necessary for letha

170 Disabling of the competent-state-specific induction of C

171 We found that disabling of the PKS gene at fertilization resulted in a

172 ts with Parkinson's disease have potentially disabling off episodes that are not predictably responsi

173 s prominent if the deceased child was either disabled or an infant, suggesting sensitive periods of e

174 plase group, 90 (21%) patients were severely disabled or died (mRS score 4-6), compared with 102 (25%

175 4.13, 2.60-6.57; p<0.0001), particularly if disabling or fatal (10.26, 4.37-24.13; p<0.0001).

176 or upper gastrointestinal bleeds were mostly disabling or fatal (45 [62%] of 73 patients vs 101 [47%]

177 which the virus persists in vivo and causes disabling or fatal diseases.

178 recurrent ischaemic stroke), and outnumbered disabling or fatal intracerebral haemorrhage (n=45 vs n=

179 mated NNT for routine PPI use to prevent one disabling or fatal upper gastrointestinal bleed over 5 y

180 h as myocardial infarction, sepsis, or other disabling or potential life-threatening events).

181 Major, disabling, or life-threatening bleeding (intention-to-tr

182 The primary safety outcome was major, disabling, or life-threatening bleeding.

183 nd the proportions of survivors with severe, disabling, or life-threatening chronic health conditions

184 lic events and the risk of life-threatening, disabling, or major bleeding were higher with rivaroxaba

185 s that obesity would continue to become more disabling over time have not been borne out.

186 one step closer to new therapies intended to disable P. aeruginosa AmpC-mediated resistance and dampe

187 Here we report efficient disabling pancreatogenesis in pig embryos via zygotic co

188 Severely ill or mentally disabled patients who were not able to fill in the quest

189 adjustments and management of these severely disabled patients.

190 , and (iii) assistive technologies to enable disabled people to operate the surrounding motorised equ

191 ial infarctions and many strokes, as well as disabling peripheral artery disease.

192 High-cost nonelderly disabled persons accounted for 14.8% of potentially prev

193 Acute flaccid myelitis (AFM) is a disabling, polio-like illness mainly affecting children.

194 Hereditary angioedema is a disabling, potentially fatal condition caused by deficie

195 Schizophrenia is a highly disabling psychiatric disorder characterized by a range

196 bsessive-compulsive disorder is a severe and disabling psychiatric disorder that presents several cha

197 Depression is a seriously disabling psychiatric disorder with a significant burden

198 ANCE STATEMENT Schizophrenia is a profoundly disabling psychiatric illness with a devastating impact

199 After disabling PVC for 4 weeks, LVEF (p = 0.01), dP/dT (p = 0

200 ensory nervous system and is both common and disabling, rendering an urgent need for non-addictive, e

201 Such a mechanism may have evolved to disable repair functions and may be a decisive factor fo

202 favorable, but some patients remain severely disabled, requiring long-term immunotherapy and/or antie

203 well as LCA1 mutations R768W and G982VfsX39, disabled RetGC1 activation by human GCAP1, -2, and -3.

204 ure thymocytes with a Galphai2 mutation that disables RGS protein binding accumulated in the perivasc

205 Post-traumatic headache (PTH) is a highly disabling secondary headache disorder and one of the mos

206 The primary outcomes were freedom from disabling seizures (Engel class 1) and drug freedom at 1

207 h 77.5% (1027 of 1325) of patients free from disabling seizures for LEAT, 74.0% (328 of 443) for vasc

208 than one-third of patients continue to have disabling seizures postoperatively.

209 velopment-other (52.3%, 212 of 405 free from disabling seizures), and for those with no histopatholog

210 cal development (50.0%, 213 of 426 free from disabling seizures), those with malformation of cortical

211 ological lesion (53.5%, 396 of 740 free from disabling seizures).

212 characterised by multiple types of frequent, disabling seizures.

213 INTRODUCTION: Aphasia is one of the most disabling sequelae after stroke, occurring in 25%-40% of

214 report here the creation of pancreatogenesis-disabled sheep by oocyte microinjection of CRISPR/Cas9 t

215 shed in 1917 for war orphans and children of disabled soldiers, we were able to study the adult morta

216 These NleDs disable specifically Jun N-terminal kinases (JNKs) and p

217 rity; some individuals rapidly progress to a disabled state whereas others experience only mild sympt

218 stication could leave patients in a severely disabled state, with the possibility that inaccurately p

219 pared with surgery, had a lower incidence of disabling stroke (0.5% vs. 1.7%), bleeding complications

220 death (80 [22.3%] vs 70 [20.2%]; p=0.40) or disabling stroke (10 [3.1%] vs 16 [5.0%]; p=0.23) were s

221 ty (Lotus, 1.9%; ES3, 1.8%; P=0.87), rate of disabling stroke (Lotus, 1.5%; ES3, 2.1%; P=0.62), or ma

222 The total number of deaths from any cause or disabling stroke at 1 year in the low-risk cohorts was 6

223 efficacy endpoint was all-cause mortality or disabling stroke at 1 year.

224 as associated with similar rates of death or disabling stroke at 2 years compared with commercial val

225 t was a composite of death from any cause or disabling stroke at 24 months in patients undergoing att

226 e primary end point, a composite of death or disabling stroke at 24 months, using Bayesian methods.

227 spect to the composite end point of death or disabling stroke at 24 months.

228 cant difference in the incidence of death or disabling stroke at 5 years after TAVR as compared with

229 point was the rate of all-cause mortality or disabling stroke at two years.

230 in the incidence of death from any cause or disabling stroke between the TAVR group and the surgery

231 All-cause mortality was 1.9%, and disabling stroke occurred in 1.8% at 30 days.

232 At 30 days, mortality was 1%, disabling stroke occurred in 2.5% of patients, and New Y

233 end point was survival at 2 years free from disabling stroke or device removal for malfunction or fa

234 ry end point was survival at 2 years free of disabling stroke or reoperation to replace or remove a m

235 as superior with respect to survival free of disabling stroke or reoperation to replace or remove a m

236 -flow pump group, remained alive and free of disabling stroke or reoperation to replace or remove a m

237 trial primary end point (survival free of a disabling stroke or reoperation to replace the pump for

238 stroke was 82%, while freedom from severely disabling stroke was 89%.

239 0.87 to 1.20), but the incidence of death or disabling stroke was higher after TAVR than after surger

240 Primary end point was all-cause mortality or disabling stroke within 12 months.

241 had similar rate of the composite of death, disabling stroke, and myocardial infarction when compare

242 n-group differences in the rates of death or disabling stroke, but reoperation for pump malfunction w

243 oint was a composite of all-cause mortality, disabling stroke, life-threatening bleeding requiring tr

244 Disabling stroke, myocardial infarction, and life-threat

245 ce the primary composite end point of death, disabling stroke, serious bleeding, or cardiac arrest.

246 primary end point was a composite of death, disabling stroke, serious bleeding, or cardiac arrest.

247 e reduction in the primary outcome of death, disabling stroke, serious bleeding, or cardiac arrest.

248 ortality at 30 days was 8%, with no cases of disabling stroke, valve embolization, or major/life-thre

249 is a wasted opportunity to prevent recurrent disabling stroke.

250 rimary end point was death from any cause or disabling stroke.

251 There were significantly more disabling strokes in unprotected patients at 30 days (1%

252 The 30-day mortality was 14%, with no disabling strokes, or repeat interventions.

253 headache and loss of smell, to confusion and disabling strokes.

254 revolutionized the stroke treatment for most disabling strokes.

255 r exposure than near infrared wavelengths to disable subjects, though near infrared sources remain at

256 e preserved across both Medicare elderly and disabled subpopulations.

257 K to R substitution (K1370R) in the M-domain disables SUMOylation.

258 le: Excessive daytime sleepiness is a common disabling symptom in obstructive sleep apnea syndrome.Ob

259 Freezing of gait is a disabling symptom in Parkinson disease and related disor

260 e necessary to understand the impact of this disabling symptom on the health care system and to ident

261 Language impairment, or aphasia, is a disabling symptom that affects at least one third of ind

262 Cirrhosis is associated with disabling symptoms and diminished health-related quality

263 it impairments are among the most common and disabling symptoms of Parkinson's disease.

264 administered using the 0.1 mL HelmJect auto-disable syringe with a Helms intradermal adapter).

265 poietic stem cell transplantation and causes disabling systemic inflammation and fibrosis.

266 iotic daptomycin, as an 'anti-antibiotic' to disable systemically-administered daptomycin reaching th

267 monocytes is required for TF inhibition, and disabling TFPI prevents aPL signaling, indicating a para

268 , those receiving two IVIg courses were more disabled than those receiving one course.

269 r by the IPCC before 2100, was sufficient to disable the aphid defensive mutualism regardless of the

270 ous individual accessory proteins to further disable the machinery.

271 is focused on beta-lactamase inhibitors that disable the most prevalent cause of antibiotic resistanc

272 Small molecules that disable the Wnt acyltransferase Porcupine (Porcn) are ca

273 ing of these glucose-sensing neurons largely disabled the response of insulin-producing cells to gluc

274 Oxygen deficiency (hypoxia) disables the basal protein synthesis machinery ('Jekyll'

275 tion of the macrocycle to a triazolium group disables the chiral information transfer to the macrocyc

276 is established, and disruption of this loop disables the EBV lytic cascade.

277 id NSF/Sec18 conformation, which potentially disables the flexibility required for Sec18 to bind to P

278 talloproteinase-directed processing of PTHrP disables the osteolytic functions of the mature hormone

279 The adg1 mutation disables the small subunit of ADP-glucose pyrophosphoryl

280 On the contrary, p.R311C Tbx20 specifically disables the Tbx20 protranscriptional activity over KCNH

281 Disabling the circadian clock causes abnormal collagen f

282 a-lactam resistance phenotype was abolished, disabling the emergence of ceftazidime-resistant mutants

283 tes ykt6 in patient-derived neurons, thereby disabling the lysosomal stress response and facilitating

284 smonate, ethylene, PAD4, and salicylate, are disabled, the hypersensitive response (HR) typical of ET

285 luding Brd4, and provides the opportunity to disable their activity and overcome epigenetic resistanc

286 t constantly creating gas bubbles that would disable their hydraulic systems.

287 uld be an effective therapeutic strategy for disabling these tumors.

288 We attempted to disable this intrinsic excitatory current by artificiall

289 Disabling this connection resulted in the inability of f

290 Sgo1 function of cohesion protection must be disabled to allow timely chromosome segregation, but how

291 They also transitioned from disabled to dead earlier (adjusted HR, 1.26 [95% CI, 0.9

292 s (healthy to dead, healthy to disabled, and disabled to dead).

293 Birds with experimentally disabled tracheal membranes were still able to phonate.

294 further show that loss of both Trp53 and Rb1 disables transcription of genes in the autophagic machin

295 Fifty-five patients with severely disabling, treatment-refractory OCD received bilateral l

296 ive dual inhibitor of CDK12 and CDK13, which disables triple-negative breast cancer (TNBC) cells.

297 Digital ulcers are a painful and disabling visible manifestation of digital vascular inju

298 -AuNPs, their latter function is essentially disabled when they bind to the target bacteria.

299 trant risk variants are often intellectually disabled, which raises epistemological questions about c

300 Because PICs can be disabled with synaptic inhibition, we hypothesized that