ライフサイエンスコーパス: disarray

1 centration-dependent increase in myofilament disarray.

2 significantly reduced anthracycline-induced disarray.

3 lar wall thickness, myocyte hypertrophy, and disarray.

4 ix pathologies are-in many cases-in striking disarray.

5 Losartan had no effect on myocyte disarray.

6 the corneas of lumican-deficient mice is in disarray.

7 hitecture intermixed with focal myofibrillar disarray.

8 societal inequities and persisting political disarray.

9 eby the loss of DLC1 results in myofibrillar disarray.

10 genic genetic variants of HCM had no myocyte disarray.

11 of myocardium and lead to significant fiber disarray.

12 healthy opportunists to exploit the temporal disarray.

13 ardial mechanics in the development of fiber disarray.

14 d calcium handling, apoptosis, and sarcomere disarray.

15 al muscle disorder associated with sarcomere disarray.

16 ntricular (LV) hypertrophy and myocyte fiber disarray.

17 ion between vascular dispersion and cellular disarray.

18 e used to evaluate sarcomere and microtubule disarray.

19 tole resulting in hypertrophy and sarcomeric disarray.

20 ESRD is a state of small-molecule disarray.

21 s altered, and the microtubule ribbon was in disarray.

22 acement collagen was in short strands and in disarray.

23 contractile proteins and profound sarcomere disarray.

24 cardiac abnormalities including myofibrillar disarray.

25 y cardiac hypertrophy, fibrosis, and myocyte disarray.

26 .4 versus 559.6+/-204.43 g, P=0.04, and mean disarray, 40.1+/-9.4% versus 20.2+/-12.6%, P=0.002, resp

27 nts (n = 62) had a greater degree of myocyte disarray (42% vs. 15% vs. 20%; p = 0.022).

28 0.7+/-0.4% versus 2.6+/-2.8%, P=0.001; mean disarray, 46.2+/-7.2% versus 24.1+/-15.9%, P<0.0001; and

29 icular arrhythmia and is likely to represent disarray after accounting for fibrosis.

30 nctional deficit is accompanied by myofibril disarray, altered calcium handling, and differential alt

31 mutant transgene showed substantial myocyte disarray and a 3-fold increase in interstitial collagen

32 ocyte level, we demonstrated that sarcomeric disarray and accumulation of the physical aggregates res

33 A weak negative correlation between myocyte disarray and age at surgery was identified (p = -0.22; p

34 umulation, and mitochondrial ultrastructural disarray and bioenergetic dysfunction - were mitigated b

35 clinical, and environmental services--are in disarray and decline in much of the developing world, pa

36 Electron microscopy revealed myofibrillar disarray and degeneration with hyaline-like inclusions.

37 g technique might be used to detect cellular disarray and degenerative changes in this sensitive circ

38 nounced hypertrophy of cardiomyocytes, fiber disarray and development of fibrosis and can be divided

39 an be used to detect and quantify myocardial disarray and fibrosis and determine myocardial mass in H

40 r detection and quantification of myocardial disarray and fibrosis by direct comparison with histopat

41 with published histology demonstrating that disarray and fibrosis invade circumferentially aligned m

42 sized that FA would be reduced in HCM due to disarray and fibrosis that may represent the anatomic su

43 d relaxation, delayed early filling, myocyte disarray and fibrosis, and increased chamber end-systoli

44 is characterized by myocardial hypertrophy, disarray and fibrosis, as in humans.

45 ant mice (20 weeks old), which develop fiber disarray and fibrosis, had diastolic and systolic kineti

46 ent of cardiac hypertrophy with myofibrillar disarray and fibrosis, in addition to activation of path

47 2 family members did not demonstrate myocyte disarray and fibrosis, indicating that this phenotype is

48 ficant cardiac hypertrophy with myofibrillar disarray and fibrosis, similar to what was observed in t

49 ndividuals with MYH11 mutations revealed SMC disarray and focal hyperplasia of SMCs in the aortic med

50 tion of sarcomeric proteins, gross myofibril disarray and growth-retarded hearts.

51 ore any outward manifestation of hair bundle disarray and hair cell loss.

52 nsgenic mouse hearts demonstrate myocellular disarray and have a reduced number of cardiac myocytes t

53 Neither phenotype showed myofibril disarray and hypertrophic hearts were hypercontractilein

54 n global longitudinal strain (GLS), myofiber disarray and hypertrophy.

55 trast, TnI(146Gly) mice showed cardiomyocyte disarray and interstitial fibrosis and suffered prematur

56 Myocyte disarray and interstitial fibrosis, pathological feature

57 n T (cTnT-Q(92)) mice, which exhibit myocyte disarray and interstitial fibrosis, to treatment with lo

58 odeling with myocardial hypertrophy, myocyte disarray and interstitial fibrosis.

59 n hypertrophic cardiomyopathy (HCM), myocyte disarray and microvascular disease (MVD) have been impli

60 by electron microscopy revealed myofibrillar disarray and mild fibrosis.

61 Disarray and MVD were independently associated with path

62 opathologic findings of myocyte hypertrophy, disarray and replacement fibrosis.

63 ltrastructural analysis showed thin-filament disarray and revealed the presence of leptomeres after t

64 only macrophage misalignment but also matrix disarray and Schwann cell disorganization, leading to mi

65 lved with cellular detection of microtubular disarray and subsequent activation of JNK/SAPK.

66 y left ventricular hypertrophy, myofibrillar disarray and sudden cardiac death.

67 ar abnormalities in the development of fiber disarray and their subsequent impact on cardiac pumping

68 a putative role of constipation in potassium disarrays and also support (with a careful consideration

69 sms, including haploinsufficiency, sarcomere disarray, and altered thick filament regulation.

70 ervation of titin, reduction in myofibrillar disarray, and attenuation of cardiomyocyte necrosis but

71 mal GBM, glomerular epithelial cells were in disarray, and endothelial and mesangial cells were extru

72 mass, contractile dysfunction, myofibrillar disarray, and fibrosis.

73 ing conditions, cadiomyocyte hypertrophy and disarray, and increased myocardial fibrosis.

74 Exercise prevented fibrosis, myocyte disarray, and induction of "hypertrophic" markers includ

75 haracterized by cardiac hypertrophy, myocyte disarray, and interstitial fibrosis.

76 tures including myocyte hypertrophy, myocyte disarray, and interstitial fibrosis.

77 haracterized by cardiac hypertrophy, myocyte disarray, and interstitial fibrosis.

78 nt of ventricular hypertrophy, cardiomyocyte disarray, and myocardial fibrosis and attenuates hypertr

79 Myocyte hypertrophy, disarray, and myocardial fibrosis constitute the histolo

80 ophy without evidence of fibrosis or myocyte disarray, and significant reduction in the left ventricu

81 n, focal areas of medial SMC hyperplasia and disarray, and stenotic arteries in the vasa vasorum due

82 ular and/or septal hypertrophy, myofibrillar disarray, and sudden cardiac death.

83 ith systemic symptoms attributed to cytokine disarray, and we have previously shown that the use of t

84 The mutants' rigid paralysis and sarcomeric disarray are consistent with unregulated contraction of

85 e objectively measured, fibrosis and myocyte disarray are difficult to assess.

86 Because myocyte dysfunction and disarray are the primary abnormalities in HCM, we reason

87 post-MI hearts exhibited increasing T-system disarray as proximity to the infarct increased.

88 n MYL2 phosphorylation with marked sarcomere disarray as the main mechanism of osimertinib cardiotoxi

89 tures of HCM include myocyte hypertrophy and disarray, as well as interstitial fibrosis.

90 ocumented disease, exercise reversed myocyte disarray (but not fibrosis) and "hypertrophic" marker in

91 ed interstitial fibrosis, attenuated myocyte disarray by 50%, and improved diastolic function in the

92 hich features misplaced cortical neurons and disarrayed cerebral lamination.

93 misshapen and have expanded metaphyses with disarrayed chondrocyte zones in growth plates and reduce

94 that is associated with cytoskeletal protein disarray, contractile dysfunction, and reduced energy pr

95 t cardiac hypertrophy, more than fibrosis or disarray, correlates with arrhythmic risk.

96 With a health system in total disarray, coverage of basic health interventions remains

97 t reduced contractile force and myofibrillar disarray despite the presence of full-length titin.

98 ty, hypocontractility, and fibrosis on fiber disarray development and examines their effect on functi

99 Myocyte disarray (disorganized cell-cell contact) and cardiac fi

100 e to the distortion of the Kunitz domains by disarrayed disulfide bonding.

101 y but their categorization currently remains disarray due to a wide diversity, resulting in frequent

102 trial and ventricular enlargement, myofibril disarray, fibrosis and mitochondrial injury, and electro

103 in the force-pCa2+ curves with cardiomyocyte disarray, fibrosis, and altered connexin43 organization.

104 thology of myocyte hypertrophy, myofibrillar disarray, fibrosis, and dystrophic calcification.

105 l subject) at the largest degree of myofiber disarray found in the clinic.

106 receded histopathologic changes, and myocyte disarray, hypertrophy, and fibrosis increased with age.

107 ypertrophic, displayed sarcomeric structural disarray, impaired contractility, and aberrant Ca(2+)-si

108 stribution of N-cadherin and reduced myocyte disarray in 2 independent randomized studies.

109 ondrial fission and mitochondrial structural disarray in brains of hypertensive rats with hypertensio

110 In vitro studies showed cytoskeleton disarray in cells transfected with mutated Cypher/ZASP.

111 olic FA could be the first in vivo marker of disarray in HCM and a potential independent risk factor.

112 n cardiomyocytes was associated with myocyte disarray in hypertrophic cardiomyopathy.

113 embryonic development, and frequently are in disarray in pathologies such as cancer.

114 rized by ventricular hypertrophy and myocyte disarray in the absence of known hypertrophic stimuli.

115 We propose that extensive myocyte disarray in the absence of marked hypertrophy is the pat

116 esolution of foveal cells, and topographical disarray in the cellular map.

117 ebellum with that of dividing cells revealed disarray in the external germinal zone.

118 tological examination showed cardiac myocyte disarray in the mutant mice, which amounted to 1-15% of

119 on cardiac structure and function leading to disarray, increased collagen synthesis, and diastolic dy

120 ), fractional anisotropy (FA) and myocardial disarray index (MDI).

121 Myocyte hypertrophy, myocyte disarray, interstitial fibrosis, and endocardial thicken

122 haracterized by cardiac hypertrophy, myocyte disarray, interstitial fibrosis, and left ventricular (L

123 nduced hypertrophy, myocyte and myofibrillar disarray, interstitial fibrosis, and premature death, ph

124 of the myocardium revealed myocardial fiber disarray, intramural coronary arteriosclerosis, and inte

125 This regional difference in fiber disarray, irrespective of perturbation severity, aligns

126 Myocardial disarray is a likely focus for fatal arrhythmia in hyper

127 e cardiac muscle, significantly higher fiber disarray is observed near the epicardium compared to the

128 Fiber disarray is predicted using a stress-based law to reorie

129 An acute hepatitic pattern with lobular disarray is seen in acute infection, during acute flares

130 acterized by cardiac hypertrophy and myocyte disarray, is the most common cause of sudden cardiac dea

131 eal growth retardation with cells in mitotic disarray manifesting disorganized spindle, misaligned an

132 anisotropy (lower values expected with more disarray), mean diffusivity (reflecting myocyte packing/

133 or storage diseases and detecting myocardial disarray, microvascular dysfunction, and abnormalities i

134 Myocardial disarray (multifocal) and increase in cardiomyocyte diam

135 embrane in normal myocardium, was diffuse in disarrayed myocardium.

136 e of the mutation carriers showed sarcomeric disarray, myofibrillar degeneration, and increased apopt

137 rastructural degenerative changes, including disarrayed myofibrils, dilated sarcoplasmic vesicles, nu

138 o be an important precursor to the costamere disarray observed in dystrophin-deficient muscle.

139 nistic basis of the progressive myofibrillar disarray observed in the Drosophila models as well as th

140 impeded in mice lacking these miRNAs, due to disarray of actin stress fibers and diminished migratory

141 ause CMD-like brain malformations, including disarray of cerebral cortical layering, fusion of cerebr

142 ndritic cells and contribute to a functional disarray of dendritic cells by inhibiting their antigen-

143 defects are related to a chaotic and random disarray of developmental mechanisms.

144 ith aberrant thickening of the aortic media, disarray of elastic fibers, and increased collagen depos

145 In addition, ultrastructure analysis reveals disarray of extracellular matrix and collagen fiber orga

146 ction, fast-to-slow myofiber conversion, and disarray of muscle triads (sites of excitation- contract

147 of HCM such as left ventricular hypertrophy, disarray of myofibers, and interstitial fibrosis.

148 essive impaired cardiac function caused by a disarray of several processes including derailed autopha

149 on that decreased RyR P(o) alone can produce disarray of the Ca2+ release process and initiate altern

150 We found substantial disarray of the functional properties of myeloid and pla

151 ype, with no significant fibrosis or myocyte disarray on histological examination.

152 on micro-CT were associated with myocardial disarray on histopathology.

153 , neither the extent nor location of myocyte disarray or cardiac fibrosis correlated with ex vivo sig

154 Myocyte hypertrophy (p < 0.001), myocyte disarray (p < 0.001), and interstitial fibrosis (p < 0.0

155 significantly different from MAC: epidermal disarray; pagetoid infiltration of dendritic and/or roun

156 Without consideration of myofiber disarray, peak myofiber tension was found to be lowest i

157 The macroscopic findings, percentage of disarray, percentage of fibrosis, and percentage of smal

158 However, focal regions of disarray persist where sublaminae do not form properly.

159 cortex heterotopias and hippocampal neuronal disarray, remain to be confirmed.

160 Quantifying fiber disarray remains critical for understanding the disease'

161 ess to endothelial dysfunction, nitric oxide disarrays, renal interstitial fibrosis, sarcopenia, and

162 sis and more frequently demonstrated lobular disarray, rosette formation, and hemorrhage than those w

163 indicates that the phenotype of myofibrillar disarray seen in HCM patients which harbor either of the

164 This neuronal disarray should be accompanied by synaptic abnormalities

165 to sarcomere protein mutations (ie, myocyte disarray, small vessel disease, myocardial scarring).

166 ivation therapy with endocrine and metabolic disarray, specifically the metabolic syndrome, resulting

167 er heart weights, less fibrosis, and greater disarray than other HCM patients (mean heart weight, 380

168 suddenly had lower heart weights and greater disarray than patients who died suddenly with unknown ge

169 ion, resulting in sarcomere loss and myocyte disarray, the life-threatening hallmarks of TNNT2 mutati

170 not associated with myocyte and myofibrillar disarray, the pathognomonic features of hypertrophic car

171 Greater network disarray underlying negative symptom severity possibly e

172 The pattern of disarray varies depending on the specific perturbation,

173 embryos displayed dilated blood vessels and disarrayed vascular architecture.

174 aused a significant increase in myofibrillar disarray versus doxorubicin alone.

175 Myocyte disarray was associated with increased levels of phospho

176 ng an active stress formulation and myofiber disarray was described using a structural tensor in the

177 phy on echocardiogram, SCD occurred, myocyte disarray was found on autopsy heart, and tissue Doppler

178 Myofibrillar disarray was present in all RAS animals and was signific

179 In addition, muscle disarray was seen adjacent to channel-associated fibrosi

180 Crypt architectural disarray was the second most frequent histologic finding

181 Disarray was unchanged.

182 With increasing myofiber disarray, we found that peak tension has to increase in

183 Cases with typical features but no myofiber disarray were considered possible HCM.

184 llagen volume fraction and extent of myocyte disarray were increased in the cTnT-Q(92) mice (placebo

185 nduced murf1 expression and caused myofibril disarray, whereas inhibiting Calcineurin activity attenu

186 e embryonic day 13.5 and developed sarcomere disarray, whereas Rbpms or Rbpms2 single-cardiomyocyte-s

187 ar regulated kinase 1/2, causes myofibrillar disarray, whereas the enlarged cardiomyocyte phenotype i

188 f hypertrophic cardiomyopathy (HCM) is fiber disarray, which is associated with various cardiac event

189 This field of study has long been in disarray with the genus level taxonomy of this group rem

190 Myofibrillar disarray with variable penetrance occurred in the left v

191 atients with troponin T mutations had severe disarray, with only mild hypertrophy and fibrosis.

192 ars to be a poor reflection of the molecular disarray within the Barrett's epithelium, and a molecula

193 solution or an increased cellular positional disarray within the representation of the amblyopic eye.

194 and fragmented elastic fibers, and cellular disarray without calcification or cell proliferation.