ライフサイエンスコーパス: disassembly

1 ity, which blocks lamina phosphorylation and disassembly.

2 is GTP cap will lead the MT to undergo rapid disassembly.

3 more likely to cause the MT to undergo rapid disassembly.

4 t coordinates virus membrane penetration and disassembly.

5 myces cerevisiae) is regulated by reversible disassembly.

6 rsists in the outer membrane after flagellum disassembly.

7 basic and disease-relevant mechanisms of SG disassembly.

8 d Arf5 activation are essential for adhesion disassembly.

9 egulation of V-ATPase activity by reversible disassembly.

10 assembly, whereas GFP-gle1A(6D) enhanced SG disassembly.

11 ng the effect of mitotic rounding on contact disassembly.

12 the prevailing concepts of PV uncoating and disassembly.

13 talk, MT stability, and hence focal adhesion disassembly.

14 and may help illuminate the process of virus disassembly.

15 pid unstable mode growth and resultant pinch disassembly.

16 some condensation followed by nuclear lamina disassembly.

17 d by myosin contraction and cofilin-mediated disassembly.

18 in the regulation of microtubule-mediated FA disassembly.

19 owever, very little is known about flagellar disassembly.

20 t, the nanomedicine can realize pH-triggered disassembly.

21 evering protein Adf1 and subsequent filament disassembly.

22 are the central regulators of actin filament disassembly.

23 upture events that lead to catastrophic axon disassembly.

24 captured at FAs, where they induce rapid FA disassembly.

25 delays between autophagosome delivery and FA disassembly.

26 assembly of dimers in the early steps of TTR disassembly.

27 ediated retention is associated with F-actin disassembly.

28 delivery of an autophagosome, triggering FA disassembly.

29 ing centromeric synaptonemal components from disassembly.

30 ucleoporins, which, in turn, promote complex disassembly.

31 l mechanisms of influenza virus assembly and disassembly.

32 cles, leading to reconfigurable assembly and disassembly.

33 state that enables force-mediated centrosome disassembly.

34 activation of ESCRTs and coordinated spindle disassembly.

35 gs is to seal the outer membrane after motor disassembly.

36 a feed-forward fashion by restraining cilium disassembly.

37 and an attenuation in the kinetics of cilia disassembly.

38 arply at anaphase onset, long before natural disassembly.

39 me forces, which is a key step in centrosome disassembly.

40 ion through the inhibition of focal adhesion disassembly.

41 ylation of membrane lipids can drive lattice disassembly.

42 and the presence of substrate triggers helix disassembly.

43 ination was unknown, as was the mechanism of disassembly.

44 y' for models of SC assembly, structure, and disassembly.

45 cted centrosome scaffolds from force-induced disassembly.

46 Fusion is associated with FA disassembly.

47 e ends switch between phases of assembly and disassembly, a behavior called dynamic instability.

48 o how compartmentalized nuclear pore complex disassembly allows cells that undergo closed mitosis to

49 Further disassembly allows sigma1 release and escape of transcri

50 e of synthesis is not explained by replisome disassembly alone.

51 protonation state of this residue in fibril disassembly, among other environmental changes.

52 a oneidensis cells, we study flagellar motor disassembly and assembly in situ.

53 essive depletion of titin leads to sarcomere disassembly and atrophy in striated muscle.

54 bxl22 and ilk loci, which regulate sarcomere disassembly and cardiomyocyte protrusion into the injure

55 red for CAP1 function in both actin filament disassembly and cell adhesion.

56 of microtubules promote polymer assembly and disassembly and connect the microtubule tips to other ce

57 e loss of stacks seen when actin assembly or disassembly and cross-linking is experimentally disrupte

58 This calcium influx causes adherens junction disassembly and cytoskeletal rearrangements to facilitat

59 ion (Ser1943), which promotes NMIIA filament disassembly and cytoskeleton rearrangement.

60 , Sema3E/PlexinD1 signaling promoted F-actin disassembly and focal adhesion reduction by activating t

61 covered attenuated DEP recruitment during SG disassembly and impaired SUMOylation.

62 widespread cardiomyocyte mitosis, sarcomere disassembly and improved left ventricular systolic funct

63 oxia (1% O(2)) specifically increases matrix disassembly and increases migratory propensity in renal

64 folded, molten globular species during early disassembly and late-stage assembly events.

65 ings explain the exquisite regulation of CMG disassembly and provide a general model for the disassem

66 ions (AJs) and tight junctions (TJs) undergo disassembly and reassembly during morphogenesis and path

67 erty of rapid (within 1 to 3 min) reversible disassembly and reassembly in intact cells exposed seque

68 , including transcription, require chromatin disassembly and reassembly mediated by histone chaperone

69 g of subunits SPT16 and SSRP1) promotes both disassembly and reassembly of nucleosomes during gene tr

70 y shedding of plasma membrane microvesicles, disassembly and remodeling of the microtubule and viment

71 ion on the flagellar bundle causes buckling, disassembly and reorganization on the other side of the

72 er demonstrate that SUMOylation regulates SG disassembly and SG formation.

73 synthetic approach that comprises mechanical disassembly and simultaneous reordering of layered trans

74 tes the lamin LMN-1 to promote timely lamina disassembly and subsequent merging of the parental genom

75 ormations undergoing continuous assembly and disassembly and that podosomes are precursors of these s

76 n by TRIM5alpha is required to induce capsid disassembly and to inhibit reverse transcription of HIV,

77 uggest a role for Myo2 in actin cytoskeletal disassembly and turnover in vivo, and that compromise of

78 positional changes SGs undergo during normal disassembly and under disease conditions.

79 defects in chaperone-mediated stress granule disassembly and vice-versa, demonstrating that cells hav

80 X domain is crucial for effective SCF(Met30) disassembly, and a concentration threshold of Shp1 recru

81 t-translationally through their recognition, disassembly, and degradation by ClpC1, which requires di

82 ch as slow ring constriction, defective ring disassembly, and delayed plasma membrane closure.

83 ly reported observations on capsid assembly, disassembly, and dimorphism.

84 1;Thm2 double-mutant MEF show enhanced cilia disassembly, and increased impairment of INPP5E ciliary

85 nt of downstream ESCRTs, compromised spindle disassembly, and led to defects in nuclear integrity and

86 ophy with reduced strength, severe sarcomere disassembly, and lethality from 2 weeks of age were shar

87 cisive infection events, cytosol arrival and disassembly, and suggest cargo remodeling as a novel fun

88 blocks effectively thrombin-induced junction disassembly, and that MAPs carrying such cells can be se

89 paration, partitioning specificity, assembly/disassembly, and the link to neurodegeneration.

90 d not degraded; 6) IRE1 cluster assembly and disassembly are mechanistically distinct; and 7) IRE1 cl

91 ction, beta1 integrins endocytosed during FA disassembly are not transferred out of Rab5 (+) endosome

92 Their assembly and disassembly are tightly coupled to cell cycle progressio

93 ells highlight virion uncoating and tegument disassembly as a divergence point between productive and

94 complexes undergo dynamic rearrangement and disassembly as Pol II moves away from the start site of

95 dicator displacement assays (RIAs), DimerDye disassembly assays (DDAs), intramolecular indicator disp

96 e develop a thermodynamics-inspired method, "disassembly asymmetry score classification (DASC)", that

97 hieve a dynamic balance between assembly and disassembly at opposite polymer ends, resulting in tread

98 h it leaves them highly dynamic and prone to disassembly at the low concentration needed for biologic

99 biquitin junction or its dynamic assembly or disassembly at the site of action exert a critical impac

100 This method exploits the catastrophic disassembly, at the acidic pH of the tumour milieu, of p

101 mble and the requirement of some capsids for disassembly before genome delivery.

102 URKA) is necessary for proper primary cilium disassembly before mitosis.

103 suggest that amyloid is actively cleared by disassembly below this threshold to suppress appearance

104 Inhibition of actin disassembly blocked NET release.

105 Disassembly, but not ribosome association, requires 40S

106 Aip1 promote cofilin-mediated actin filament disassembly, but the mechanism is somewhat controversial

107 Zr(4) undergoes disassembly by 1 equiv of peroxide (per Zr) to yield sma

108 on of intermediate states in MT assembly and disassembly by promoting both longitudinal and lateral t

109 a DNA-RNA nanotube system whose assembly and disassembly can be temporally controlled at physiologica

110 lone and together with Thm2, regulates cilia disassembly, ciliary entry of membrane-associated protei

111 P dysregulation and defective stress granule disassembly contribute to IBM-like disease in Ulk1/2-def

112 and alphaSNAP, which coordinate the assembly-disassembly cycle of neuronal SNARE complexes.

113 The assembly/disassembly cycles of dynamin promote continuous actin b

114 of the effects of temperature and pH on the disassembly (D) and organization (O) steps of the proces

115 The hydrolysis (disassembly, D) and rearrangement (organization, O) step

116 WDR62-CEP170-KIF2A pathway promoting cilium disassembly, disruption of which contributes to microcep

117 ctivity by palbociclib blocked DREAM complex disassembly during cell cycle entry.

118 is an additional key element for SCF(Met30) disassembly during heavy metal stress.

119 ase activity regulates timely stress granule disassembly during stress recovery.

120 prevents a futile cycle of MCC assembly and disassembly during the active mitotic checkpoint.

121 ty is biphasic, cycling through assembly and disassembly during the cell cycle.

122 ic cell rounding-dependent cell-cell contact disassembly during the last rounds of cell cleavages.

123 mary cilium size, architecture, and assembly-disassembly dynamics are under rigid cell cycle-dependen

124 Our results demonstrate that assembly and disassembly dynamics of filopodia tip complexes are dete

125 for cell morphogenesis, while actin-filament disassembly dynamics relax stress and facilitate cortica

126 ings suggest that instead of robust assembly-disassembly dynamics, persistent Drp1 higher-order oligo

127 re of the actin density, can account for the disassembly dynamics.

128 We reveal dozens of disassembly-engaged proteins (DEPs), some of which play

129 ntifying a new role for the core proteins in disassembly events, these data highlight the possibility

130 ed by calcium-calmodulin, triggering network disassembly, expansion, and subsequent compaction by myo

131 (2 n+) assemblies was examined by performing disassembly experiments with pyridine and with trifluoro

132 clease activity and overexpression of an EJC disassembly factor in Arabidopsis reduced the accumulati

133 an pathogen Staphylococcus aureus is a minor disassembly factor.

134 the Cu(I) and Cu(0) states leads to network disassembly, forming Cu(I) /Cu(0) solutions, respectivel

135 ntagonizes phyB signaling by triggering phyB disassembly from photobodies.

136 duce photobody number by stimulating phyB-FP disassembly from selective thermo-unstable photobodies.

137 ally reduced GTP turnover restricts oligomer disassembly from the mitochondrial surface relative to m

138 th cdr2 mutants that affect node assembly or disassembly, gross defects in division site positioning

139 T)-mediated assembly and kinesin-13-mediated disassembly in different flagellar pairs.

140 ase 2alpha (CK2alpha) triggers G3BP1 granule disassembly in injured axons.

141 hat this subcomplex persists after flagellum disassembly in other phyla as well.

142 ate that two processes contribute to ciliary disassembly in response to cessation of anterograde IFT:

143 the TRAIP ubiquitin ligase drives replisome disassembly in response to incomplete DNA replication, t

144 nuclear extract undergoes ubiquitylation and disassembly in the absence of any DNA, and DNA digestion

145 For amyloid disassembly in the blood, it is proposed that the pH cha

146 rescuing the reduced rate of actin filament disassembly in the CAP1 knockdown HeLa cells.

147 addition, GMPCPP MTs undergoing cold-induced disassembly in the presence of 4R tau (and to a much les

148 hiometric excess over ssDNA can cause D-loop disassembly in vitro; furthermore, we show that this RAD

149 de-priming by preventing trans-SNARE complex disassembly; in this model, complexin-1 also impairs de-

150 Possible functions of this local disassembly include helping sister centrosomes move apar

151 ), some of which play functional roles in SG disassembly, including small ubiquitin-like modifier (SU

152 ble and mature focal adhesions that resisted disassembly induced by the myosin II inhibitor, blebbist

153 ndles, and increased their resistance to the disassembly-inducing reagents Ca(2+) and podophyllotoxin

154 nse to increased membrane tension, and their disassembly influences the lipid organization of the PM.

155 Disassembly inhibits V-ATPase activity under low-glucose

156 V-ATPase activity is regulated by reversible disassembly into autoinhibited V(1)-ATPase and V(o) prot

157 earrangement from the kinetic product of the disassembly (IPC-1P) to the thermodynamic product of the

158 In addition, stress granule disassembly is accelerated by an ULK1/2 agonist, suggest

159 Nanotube assembly and disassembly is controlled with minimal synthetic gene sy

160 cognize their target membranes, and how coat disassembly is coordinated with vesicle fusion and cargo

161 Disassembly is critically important, as misregulation or

162 alphaSyn aggregates, suggesting that fibril disassembly is linked to the increased rate of peptidyl-

163 One step in disassembly is the release of the general transcription

164 uality control, but the mechanistic basis of disassembly is unclear.

165 us to quantify the nucleation, assembly, and disassembly kinetics of Tpm1.8 on single filaments and a

166 rthoreovirus that regulates heat resistance, disassembly kinetics, and replicative fitness.

167 orld ecosystems, where community assembly or disassembly may be non-random and influenced by external

168 Further definition of tegument disassembly may permit the development of interventions

169 Our data suggest a possible disassembly mechanism by which N-terminal ubiquitination

170 we propose a model where a length-dependent disassembly mechanism controls multiple flagellar length

171 iation (SID) are used to investigate the TTR disassembly mechanism(s) and the effects of temperature

172 idual receptors differ in their assembly and disassembly mechanisms and how these differences contrib

173 Detailed understanding of the self-assembly/disassembly mechanisms is obtained from real-time observ

174 We show that this 'active disassembly' model of flagellar length control explains

175 s are consistent with a catastrophic mode of disassembly, not enhanced severing alone.

176 No disassembly occurred while the torque remained high, but

177 al, secretion of protons from 1 triggers the disassembly of 2 and the released protease is transferre

178 Here, we reconstitute the disassembly of a collided polysome in a mammalian cell-f

179 foci per cell after UV, consistent with the disassembly of a fraction of the replisomes.

180 show that this is possible by the controlled disassembly of a metallosupramolecular polymer containin

181 Cdc48 cofactor for signal-induced selective disassembly of a multisubunit protein complex to modulat

182 ecular mechanisms governing the assembly and disassembly of a transcriptionally active RAG locus chro

183 ent, yet can dissociate from RNApII to allow disassembly of abnormally long-lived (i.e., stalled) elo

184 wn about how mechanical forces influence the disassembly of actin filament networks, specifically, th

185 vity, enhanced lymphangiogenic capacity, and disassembly of actin skeleton and VE-cadherin junctions,

186 but their simultaneous depletion results in disassembly of actin-tropomyosin filaments, loss of forc

187 n crosslinks, whereas in mitosis it triggers disassembly of all replisomes that remain on chromatin.

188 steps in autophagy, in part by delaying the disassembly of autophagy proteins from mature autophagos

189 axons after PNS nerve injury correlates with disassembly of axonal G3BP1 granules as well as increase

190 t phase) followed by a rapid and near unison disassembly of axons over the next 3 h (catastrophic pha

191 In bacteria, disassembly of elongating transcription complexes (ECs)

192 a B kinase (AURKB) subunit of the CPC caused disassembly of F-actin and keratin between asters and lo

193 aster boundaries and caused AURKB-dependent disassembly of F-actin and keratin that propagated ~40 m

194 GTP hydrolysis by dynamin triggers disassembly of fully assembled dynamin helices, releasin

195 ssays, 1,6-hexanediol treatment led to rapid disassembly of green fluorescent protein (GFP)-MxA struc

196 ure signaling mechanism via dynamic assembly/disassembly of individual photobodies possessing distinc

197 Coordinated assembly and disassembly of integrin-mediated focal adhesions (FAs) i

198 ition of bacterial cell wall biosynthesis by disassembly of key divisome proteins, the cornerstone to

199 ole for a putative chaperone (RuvBL) in this disassembly of large clusters.

200 of aryl ether linkages is a key step in the disassembly of lignin to its monolignol components, wher

201 rmediate activities with the development and disassembly of local actin cytoskeletal networks.

202 mical chemical process involves assembly and disassembly of many molecules in multiple cellular compa

203 ation of the mitotic checkpoint requires the disassembly of MCC.

204 damental role in regulating the assembly and disassembly of membraneless organelles.

205 surements of guanidine-hydrochloride-induced disassembly of methemoglobin and previous measurements o

206 p31(comet) promotes the disassembly of mitotic checkpoint complexes by liberatin

207 The regulated assembly and disassembly of motor-adaptor complexes ensures that carg

208 Controlling the assembly and disassembly of nanoscale protein cages for the capture a

209 nce depletion of SON leads only to a partial disassembly of NS, while co-depletion of SON and SRRM2 o

210 w that nuclear fission is achieved via local disassembly of nuclear pores within the narrow bridge th

211 ranscription of genomic DNA requires partial disassembly of nucleosomes to allow progression of polym

212 This remodeling involves disassembly of old microtubules and nucleation of new mi

213 teostasis regulators can drive formation and disassembly of protein aggregates in both conformational

214 expression, cellular transit, assembly, and disassembly of replicative and non-replicative forms of

215 by which TRIM5alpha can induce the abortive disassembly of retroviral capsids have remained obscure,

216 llular NAD+ concentration contributes to the disassembly of SARM1's peripheral ring, which allows for

217 hat the acetylation of G3BP1 facilitates the disassembly of SGs, offering a potential avenue to mitig

218 ediated ATP hydrolysis drives the mechanical disassembly of SNAREs into individual coils, permitting

219 PFK degradation is triggered by the disassembly of stress fibres, which releases the PFK-tar

220 Defects in the assembly and disassembly of stress granules are linked to neurodegene

221 y functionalities encompassing unfolding and disassembly of such substrates in different subcellular

222 siae Rnq1 amyloid reduces chaperone-mediated disassembly of Sup35 amyloid, promoting its persistence

223 -switch in TRF2 coordinates the assembly and disassembly of t-loops during the cell cycle, which prot

224 ith RPS2B to facilitate the dynamic assembly/disassembly of the 90S/SSU processome during ribosome bi

225 Upon stimulation, cells exhibited rapid disassembly of the actin cytoskeleton, followed by shedd

226 viding an unprecedented view of assembly and disassembly of the active site mediated by an arginine r

227 The disassembly of the amphiphilic biomass is thus enabled t

228 (TD) of mouse sensory neurons causes a rapid disassembly of the axonal MPS, which occurs prior to pro

229 e molecules leads to reversible assembly and disassembly of the base-centered cubic (bcc) and face-ce

230 tabilizing and thereby preventing functional disassembly of the capsid shell in infected cells.

231 ail to encase the viral genome and (2) rapid disassembly of the capsid, which express at late and ear

232 cle-regulated spatially defined assembly and disassembly of the CPC condensate at the inner centromer

233 elasticity-based model for the reshaping and disassembly of the dynamin scaffold.

234 d new insights into the dynamic assembly and disassembly of the exocyst complex during vesicle tether

235 stent with extract observations, we observed disassembly of the keratin network between asters in zyg

236 Disassembly of the LFC and release of the RagC-GAP activ

237 Disassembly of the networks was not achieved if IL-17A b

238 This reversible disassembly of the polyMOC network can occur in the pres

239 thymocytes depends on Ikaros and occurs with disassembly of the RAG locus chromatin hub.

240 Finally, we show that disassembly of the Reissner fiber is also associated wit

241 arks of muscle atrophy, including an ordered disassembly of the sarcomere associated with upregulatio

242 ic) stress within the cell envelope promotes disassembly of the tripartite efflux complex CusCBA, a s

243 ng infection(5-8), reverse transcription and disassembly of the viral core have conventionally been c

244 tood, ubiquitin-dependent events lead to the disassembly of the viral core, prior to the accumulation

245 D to preformed alphaSyn fibrils leads to the disassembly of these fibrils.

246 By promoting disassembly of this protein complex, mechanical forces w

247 assembly and provide a general model for the disassembly of ubiquitylated protein complexes by Cdc48.

248 n-mediated EC permeability by inhibiting the disassembly of VE-cadherin at adherens junctions.

249 It promotes the removal of M1 and induces disassembly of vRNP bundles.

250 le artificial protein cage, the assembly and disassembly of which can be controlled by metal coordina

251 ically impaired the reformation, but not the disassembly, of FAs.

252 or foe," they might influence the assembly, disassembly, or material properties of cellular RNP gran

253 Assembly-Disassembly-Organization-Reassembly (ADOR) method overco

254 ment (organization, O) steps of the assembly-disassembly-organization-reassembly (ADOR) process for t

255 lations of holointermediates and equilibrium disassembly parameters were estimated quantitatively for

256 into blood plasma after red cell lysis, the disassembly pathway appears to be dominated by early hem

257 ric hemichrome intermediates occur along the disassembly pathway inside red cells, where the hemoglob

258 ortunities to gain unparalleled insight into disassembly pathways.

259 tes that the duration of stalled microtubule disassembly predicts whether a microtubule is stabilized

260 h levels of glucose induce rapid microtubule disassembly preferentially in the periphery of individua

261 of active matter wherein asymmetric filament disassembly preserves filament number despite sustained

262 C4b inhibits capsid disassembly, preventing endosomal escape and cytosolic a

263 uctural details and the forces governing the disassembly process are revealed with single particle re

264 the seam region tends to separate during the disassembly process of an MT.

265 n turnover, phenology, and seasonal assembly/disassembly processes in empirical plant-pollinator comm

266 ular recognition-controlled kinetic assembly/disassembly processes within artificial supramolecular p

267 found that TGFbeta enhanced the assembly and disassembly rates of paxillin-containing adhesions in an

268 ndogenous MxA also displayed tonicity-driven disassembly/reassembly.

269 Following translation inhibition, polysome disassembly releases 48S preinitiation complexes (PICs).

270 n can be accelerated by axonal G3BP1 granule disassembly, releasing axonal mRNAs for local translatio

271 mporal control over droplet condensation and disassembly remains challenging.

272 Many studies have shown that FA disassembly requires Ca(2+) influx, however our understa

273 Here, we describe that the efficient DPC disassembly requires Ddi1, another conserved predicted p

274 We first show that motor disassembly results in stable outer membrane-embedded su

275 We have proposed a global disassembly scheme for human methemoglobin, linking hemi

276 p by proteomic dissection of the SG temporal disassembly sequence using multi-bait APEX proximity pro

277 ow decreased cilia assembly, increased cilia disassembly, shortened primary cilia, a retrograde IFT d

278 a cluster that can serve as the pH-sensitive disassembly switch after entry into a target cell.

279 entify a mitotic pathway of global replisome disassembly that can trigger replication fork collapse a

280 or, vesicle-fusing ATPase (Sec18/NSF)-driven disassembly that enables a new round of membrane fusion.

281 cytoskeletal bundles: filament assembly and disassembly, the attachement-detachment dynamics of moto

282 Upon disassembly, the designed proteins disrupt lipid membran

283 ong been mechanistically linked to cell wall disassembly, the importance of the fruit cuticle in wate

284 osis with two rounds of microtubule assembly-disassembly, the roles of motor proteins remain unexplor

285 s tau phosphorylation to enhance microtubule disassembly to acutely enhance GSIS.

286 iomyocytes, such as the control of sarcomere disassembly to allow cytokinesis, require more investiga

287 and ER remodeling, where it regulates ESCRT disassembly to maintain nuclear envelope integrity and p

288 e chiral superhelical fibers show reversible disassembly to monomers upon hydrolysis of ATP catalyzed

289 trate cellular membranes, and undergo capsid disassembly to reach an intracellular destination that s

290 HIV-1 capsid core disassembly (uncoating) must occur before integration of

291 ces CHCHD10, promotes OPA1-mitofilin complex disassembly via CHCHD10, and impairs mitochondrial fusio

292 xtracellular and intracellular bioorthogonal disassembly via omnidirectional tetrazine-triggered clea

293 Network disassembly was accompanied by decrease in neutrophil in

294 ty increase upon latrunculin B-induced actin disassembly was detected only with cDC and sDC, which su

295 Pyridine-induced disassembly was found to be most pronounced for Pd compl

296 e mutants display progressive Reissner fiber disassembly, which is concomitant with the emergence of

297 knockdown results in OPA1-mitofilin complex disassembly, while TDP-43 overexpression also reduces CH

298 oint protein, MAD1, where it coordinates NPC disassembly with kinetochore assembly.

299 ovided variable levels of protection against disassembly, with the strongest protection by Tpm3.1 and

300 t additional rounds of spindle formation and disassembly without DNA re-replication, leading to aberr