ライフサイエンスコーパス: disc

1 to form death-inducing signaling complexes (DISC).

2 P cells isolated from non-degenerated lumbar disc.

3 ineages determined before they enter the eye disc.

4 nd hth expression levels in the eye imaginal disc.

5 result of degeneration of the intervertebral disc.

6 Myc supercompetitors in the Drosophila wing disc.

7 sm first demonstrated in the Drosophila wing disc.

8 eflective opacity as a cap on the left optic disc.

9 the separated cells within the microfluidic disc.

10 enerative mechanisms associated with the TMJ disc.

11 nned using 4.5-mm OCTA scans centered on the disc.

12 remont, CA) 4.5-mm OCTA scan centered on the disc.

13 ond the standard areas surrounding the optic disc.

14 e extension that each covers half of the eye disc.

15 and growth by diffusing throughout imaginal discs.

16 adhesion in shaping Drosophila wing imaginal discs.

17 eropia, short axial length and crowded optic discs.

18 cal microscopy images of Drosophila imaginal discs.

19 ofilm formation, and tumorigenesis of potato discs.

20 d dMYC-dependent overgrowth of wing imaginal discs.

21 fails-something we observe directly in wing discs.

22 rts in the ovary, early embryo, and imaginal discs.

23 electrolyte leakage from freeze-thawed leaf discs.

24 lipid ordering in the centre and rim of the discs.

25 dopsin packing density compared to wild-type discs.

26 ent Hh signaling in Drosophila wing imaginal discs.

27 absence of desmin filaments at intercalated discs.

28 d cup enlargement (45.5% [44-47]) (P < .001) discs.

29 Meta-Disc 1.4 was used to pool data for all cases of IE and i

30 %), optic disc drusen (47%), anomalous optic discs (44%), isolated optic neuritis (19%), and optic at

31 Forty bovine dental discs (6 cm x4 cm) were pigmentated and randomly allocat

32 The temporomandibular joint (TMJ) disc, a fibrocartilaginous structure between the mandibl

33 rtant to determine if massive stars form via disc accretion, like their low-mass counterparts.

34 bility to capture the perimeter of the optic disc accurately can be limited in the setting of peripap

35 outer segment is constantly renewed with new discs added at its base every day.

36 t nerve fiber growth into the intervertebral disc after injury-induced inflammation may contribute to

37 (petri dishes with solid media, filter paper discs, air harvesters, and liquid transport media) and a

38 Further, we demonstrate the utility of DISC algorithm to probe cooperativity between multiple b

39 Fovea-to-disc alignment (FoDi) software of the spectral-domain op

40 Deformations of the disc and adjacent PPR were measured by comparing positio

41 lood flow velocity index (BFVi) in the optic disc and in each of multiple arterial and venous segment

42 y is located asymmetrically around the optic disc and is closest to the optic disc nasally.

43 e retinal nerve fiber layer around the optic disc and macula in patients with cerebral vein thrombosi

44 l Zeiss Meditec, Dublin, CA) using the optic disc and macular scanning protocols.

45 O-1 and Cx43 at the ventricular intercalated disc and modestly decreased left ventricular ejection fr

46 because it had an unusual affinity for the Z-disc and mutant DNAJB6.

47 duction, particularly adduction, deforms the disc and peripapillary vasculature.

48 Observational Procedure: The disc and PPR were imaged by scanning laser ophthalmoscop

49 SP70 normally diffused rapidly between the Z-disc and sarcoplasm, the rate of diffusion of HSP70 in L

50 ined by 2 independent readers from the optic disc and visual field reading centers of the OHTS.

51 all tumours not extending close to the optic disc and/or fovea.

52 e organoids repopulated decellularized liver discs and formed liver-like tissue.

53 Thirty EDML were stripped from corneoscleral discs and placed in a well plate containing organ cultur

54 upling of desmin filaments from intercalated discs and their structural disorganization.

55 t in 1 patient with history of morning glory disc anomaly and therefore transposition surgery was onl

56 Articular cartilage (AC) and intervertebral discs are cartilaginous tissues with a similar biochemic

57 Larger optic disc area (per mm(2); beta = 0.78; P < 0.001) was associ

58 Chinese Americans showed the largest CDR and disc area after adjusting for age and gender (all P < 0.

59 nt developed fibrous tissue formation at the disc area as well as an epiretinal membrane formation, f

60 Disc area was positively associated with RNFL thickness

61 diabetes, greater axial length (AL), bigger disc area, and lower scan signal strength were associate

62 After adjusting for age, disc area, and other confounders, significantly lower cp

63 measures included the changes in cup volume, disc area, and rim area on OCT.

64 Race, age, AL, disc area, and scan signal strength consistently were as

65 OP, central corneal thickness (CCT) and AXL, disc area, and signal strength of the OCT scan on retina

66 Age, sex, AXL, disc area, and signal strength of the scan were signific

67 , presence of cataract, OCT signal strength, disc area, hypertension, diabetes, and hyperlipidemia, e

68 Their size as percentage of disc area, ratio of length to midpoint width, and locati

69 s were significant: rim area, cup volume, or disc area.

70 ll-demarcated bilateral GA (lesion size, 1-7 disc areas) without evidence of or previous treatment fo

71 ents in the anterior compartment of the wing disc, ASP and myoblasts, and activates genes in each tis

72 of Hh signal transduction are common to the disc, ASP and myoblasts, whereas others are tissue-speci

73 or ectopic growth - loss of TRIM32 in a wing disc-associated tumor model reduces glycolytic metabolis

74 o sintering into monolithic, polycrystalline discs at 200 degrees C and about 300 MPa of uniaxial pre

75 c, remnant of fetal vasculature on the optic disc (Bergmeister's papilla).

76 ated with degeneration of the intervertebral disc, but specific mechanisms of pain generation in this

77 /- 7 years, IOP was 16 +/- 2.1 mm Hg, cup-to-disc (C/D) ratio was 0.9 +/- 0.08, and MD assessed via H

78 al neuropathy (GON), and estimates of cup-to-disc (C/D) ratios.

79 ared in terms of formats of release (compact disc [CD] via pick up, CD via mail, e-mail, online patie

80 Dpp is produced in a limited set of imaginal disc cells and functions as a classic morphogen to regul

81 lowing severe tissue injury, Drosophila wing disc cells that survive executioner caspase activation c

82 al vessel calibers were measured at an optic disc centered inner and outer zone.

83 In wing imaginal discs, CKI loss leads to elevated Expanded and Crumbs le

84 th optic disc pit in the right eye and optic disc coloboma with a focal pit like excavation in the le

85 to induce Death-Inducing Signaling Complex (DISC) components, and decreased FasL and CD36 expression

86 se proteins (PSD95 and SAP102), and Spinning Disc confocal Microscopy (SDM), to estimate the number o

87 Using an ex vivo imaginal disc culture system, we showed that mitotically active s

88 ted with visual field (VF) defects and optic disc cupping.

89 n worsening of visual field defect and optic disc damage, patients could receive selective laser trab

90 Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) as major cause of chronic low b

91 The intervertebral disc degeneration (IVDD)-related diseases occur in more

92 rapeutics for treatment of low back pain and disc degeneration.

93 tion for developing treatment strategies for disc degeneration.

94 mbrane proteins are reconstituted in peptide discs, deposited on a solid surface, and the peptide mol

95 valent (CRVE), and extended-zone vessels (>2 disc diameters from the optic disc margin) were summariz

96 MRW and pRNFL thickness around the disc (diameters: 3.5 mm, 4.1 mm, and 4.7 mm) were obtain

97 Disc diffusion antimicrobial susceptibility assay showed

98 Agar disc diffusion assay was used to analyse the antimicrobi

99 AMR profiles were assessed by the disc diffusion method, and trends over time were evaluat

100 the isolated strains was determined using a disc diffusion method, where the tested strains exhibite

101 ial resistance of isolates was determined by disc diffusion using Clinical and Laboratory Standard In

102 Imaging of the demineralized discs displayed the same glassy amorphous layer appearan

103 AGO1 depletion in wing imaginal discs drives a significant increase in ribosome biogenes

104 ed in intracranial hypertension (62%), optic disc drusen (47%), anomalous optic discs (44%), isolated

105 Optic disc drusen (ODD), present in 2% of the general populati

106 ogy clinics of the international ODDS (Optic Disc Drusen Studies) Consortium between April 1, 2017, a

107 here were no significant deformations of the disc during abduction by older subjects.

108 uspects based on the appearance of the optic disc during clinical examination.

109 s constructed on a regular digital versatile disc (DVD) to immobilize a panel of 12 allergen extracts

110 larity (74%), vitreous cell (53%), and optic disc edema (52%).

111 tant entity that is commonly misdiagnosed as disc edema or choroidal neovascularization.

112 ombination of retinitis, vitritis, and optic disc edema without optic nerve enhancement should prompt

113 tions, optic neuropathy presented with optic disc edema, often associated with uveitis, retinitis, or

114 n at visual symptom onset demonstrated optic disc edema.

115 or the first time, utilizing a rotating ring-disc electrode (RRDE) assembly for detecting changes in

116 chemical methods, such as thin film rotating disc electrodes are employed to study the materials' sta

117 Measurement of optic disc elevation appears promising for the detection of el

118 Optic disc elevation greater than 0.04 cm attained sensitivity

119 ea under the curve of highest measured optic disc elevation to detect intracranial pressure greater t

120 Optic disc elevation was also measured.

121 Limited nutrient supply in the avascular disc environment restricts the production of ATP which i

122 legic (Dpp) pattern Drosophila wing imaginal discs, establishing gene expression boundaries at specif

123 Optic disc examination showed severe glaucomatous cupping.

124 ntraocular pressure (IOP) measurement, optic disc examination, and static automated perimetry.

125 o water - as demonstrated by a rotating ring disc experiment - and performed quasi-reversible heterog

126 Multi-hour R(N) measurements following leaf disc exposure to a wide array of primary carbon metaboli

127 The platform shaped as a compact disc facilitates long-term bacterial culture without ext

128 aluated in 4 quadrants surrounding the optic disc for ONH images.

129 llular vesicles, or ectosomes, and that both disc formation and ectosome release rely on the actin cy

130 ecular mechanisms responsible for initiating disc formation from the ciliary membrane.

131 Disc-fovea angle determined by fundus photography (P-DFA

132 As discs grow, Dpp gradients expand, keeping relative bound

133 the role of TGFbeta/Activin-like ligands in disc growth control remains ill-defined.

134 of maculopathy, the dose to 20% of the optic disc had the largest impact on optic neuropathy, dose to

135 eyes with ODH in 2 different sectors of the disc had worse progression rate than eyes with ODH in 1

136 adjusting for confounders, senile sclerotic discs had the lowest cpCD (37.1% [95% confidence interva

137 per mmHg; 95% CI, 1.02-1.12; P = 0.008), and disc hemorrhage at visit 1 (HR, 2.08; 95% CI, 1.07-4.04;

138 Disc hemorrhage during the follow-up was also important,

139 Vascular dysregulation may contribute to disc hemorrhage formation in ocular hypertension.

140 Bilateral disease, higher IOP, and disc hemorrhage were confirmed as risk factors for deter

141 The origin of blood in glaucoma-related disc hemorrhages (DH) remains unknown.

142 on of one gait cycle in patients with lumbar disc herniation (LDH).

143 05 patients in the case group who had lumbar disc herniation between L1-S1 level and there were 187 p

144 In the case group, lumbar disc herniation was detected mostly at L4-5 and L5-S1 le

145 were 'herniated nucleus pulposus' or 'lumbar disc herniation' or 'back pain' and their age range was

146 elationship between lumbar back pain, lumbar disc herniation, and erector spinae and multifidus muscl

147 ients in the control group who had no lumbar disc herniation.

148 The results suggest that TMJ disc homeostasis may be vulnerable to pathological loadi

149 Intercalated discs (ICD), specific cell-to-cell contacts that connect

150 istical learning with the Viterbi algorithm, DISC idealizes single-molecule trajectories up to three

151 Rotterdam; OR, 0.90; 95% CI, 0.85-0.95 using disc image grading).

152 With disc image grading, participants who performed moderate

153 on the Rotterdam criteria and 0.3% based on disc image grading.

154 criteria and 7 (0.5%) had glaucoma based on disc image grading.

155 not entirely cover tumor mainly close to the disc in 32% versus 18% of eyes, respectively (P = 0.052)

156 Displacement of the nasal hemi-disc in adduction was greater at 38.5 +/- 1.7 mum (stand

157 ISH) for use in the Drosophila wing imaginal disc in order to measure nascent and mature mRNA of gene

158 ction proteins and localizes to intercalated discs in cardiomyocytes.

159 eaks, that is, their distance from the optic disc, into 5 groups.

160 ed visual acuity (BCVA) and foveal and optic disc involvement were associated with poor response to t

161 Overexpression of AR2 in wing imaginal disc is sufficient to cause notched wing margin.

162 rative means to treat damaged or degenerated discs is hindered by a lack of basic understanding of th

163 oss of ESCRT function in Drosophila imaginal discs is known to cause neoplastic overgrowth fueled by

164 Intervertebral disc (IVD) degeneration activates the differentiation of

165 Intervertebral disc (IVD) degeneration and consequent low back pain (LB

166 enescence is a contributor to intervertebral disc (IVD) degeneration and low back pain.

167 low back pain, the cascade of intervertebral disc (IVD) degeneration is initiated by the disappearanc

168 Back pain is linked to intervertebral disc (IVD) degeneration, but clinical studies show the r

169 of cilia and IFT80 protein in intervertebral disc (IVD) development, maintenance, and degeneration ar

170 Intervertebral disc (IVD) disease (IDD) is a complex, multifactorial di

171 The intervertebral disc (IVD) has long been considered unique to mammals.

172 tral gelatinous region of the intervertebral disc (IVD).

173 esin-binding phosphoprotein 50) is a PSD-95, disc large, zona occludens-1 adapter that acts as a scaf

174 kdown also results in the down-regulation of Discs Large MAGUK Scaffold Protein 3 (DLG3), resulting i

175 pendent and independent activities of Scrib, Discs-large (Dlg), and Lethal giant larvae (Lgl) using t

176 pheral vascular leakage, 5 eyes showed optic disc leakage, and 6 eyes had leakage within the macula.

177 SP), which contains a cylindrical tail and a disc-like head.

178 on its way to organizing into a large-scale disc-like shape, with the effective force increasing as

179 ered by a lack of basic understanding of the disc load-deformation characteristics in vivo.

180 This novel label-free 'lab on a disc' (LoaD) platform can successfully detect endothelia

181 Cx (connexin) 40 expression and intercalated disc localization.

182 ssues of many organisms, Drosophila imaginal discs lose the ability to regenerate as they mature.

183 metrics for several structures (i.e., optic disc, macula, retina, globe, lens, ciliary body) correla

184 We propose the unconventional use of peptide discs made by phospholipids and amphipathic 18A peptides

185 ks (branched/curved vessels, fovea, or optic disc) mapped the tumor location and extent.

186 ding the distance between the temporal optic disc margin and foveal center, and the vertical diameter

187 PPR within 1 radius of the disc margin underwent 7.6 +/- 1.6 mum average temporal d

188 midpoint width, and location relative to the disc margin were also analyzed.

189 ne vessels (>2 disc diameters from the optic disc margin) were summarized as mean width of arterioles

190 act human discs where a single dose improved disc matrix homeostasis.

191 activated via Polycomb-mediated silencing as discs mature (Harris et al., 2016).

192 Neither optic disc measures predicted VF progression in any of the exp

193 tent with coordinated activation of neuronal DISC mediated death cascades and neuroimmune gene induct

194 Altogether, the peptide disc mediated formation of supported lipid bilayers with

195 Imaging of rod photoreceptor outer-segment disc membranes by atomic force microscopy and cryo-elect

196 l GPCR, embedded in native rod outer segment disc membranes from photoreceptor cells of the retina in

197 y, atomic force microscopy reveals that many disc membranes in Prcd-KO rod photoreceptor neurons are

198 sin incorporation and packaging density into disc membranes, a process which, when dysregulated, like

199 ocalized to photoreceptor outer segment (OS) disc membranes.

200 g PRCD display disoriented and dysmorphic OS disc membranes.

201 ed cilium filled with hundreds of flattened 'disc' membranes that provide vast light-absorbing surfac

202 in good accordance with the theory of lipid disc micelle vesiculation.

203 ws that the machinery for visual transducing discs might still be present but not organized in one pa

204 shed that PRCD is required for high fidelity disc morphogenesis, its precise role in this process rem

205 tin network resides precisely at the site of disc morphogenesis, we employed a unique proteomic appro

206 well as its contribution to photoreceptor OS disc morphogenesis, we generated a Prcd-KO animal model

207 recent breakthroughs in the understanding of disc morphogenesis, with a focus on the molecular mechan

208 mponents of this network potentially driving disc morphogenesis.

209 ange of conditions and exhibit the bilayered-disc morphology of ideal bicelles even at low lipid-to-d

210 New discs (N = 18) without biofilm were exposed to the treat

211 d the optic disc and is closest to the optic disc nasally.

212 other larval organs, including gut, imaginal discs, neurons, fat body, tracheae, muscles and hemocyte

213 patients had neovascularization of the optic disc (NVDs) and one patient had neovascularizations else

214 Observational procedure: optic disc OCT images were obtained of both the retinal nerve

215 ntly by 15% in nine astronauts without optic disc oedema (P < 0.005).

216 upright values is a suspected cause of optic disc oedema in astronauts.

217 ght and this led to the development of optic disc oedema in one-half of the subjects.

218 The results of the two astronauts with optic disc oedema suggest that both increases and decreases in

219 op structural ocular changes including optic disc oedema that resemble signs of intracranial hyperten

220 gnificantly in nine astronauts without optic disc oedema, suggesting that the cephalad fluid shift du

221 cumscribed the thicker RNFL around the optic disc of healthy and glaucomatous eyes, and it was used t

222 refore developed a novel ex vivo model using discs of porcine and human cornea and sclera (5 mm diame

223 +/- 222 cells/mm(2) for the 5 corneoscleral discs of the control group.

224 In the wing disc, overexpression of wdp inhibits Hh signaling, which

225 substantially resolved, and there was optic disc pallor.

226 tions between OSA and glaucoma-related optic disc parameters in young adults.

227 oma diagnosis may be influenced by the optic disc phenotype.

228 llary density (cpCD) of 4 glaucomatous optic disc phenotypes in 193 eyes of 141 glaucoma patients and

229 -measured vessel density differs among optic disc phenotypes.

230 A total of 9282 pairs of optic disc photographs and SDOCT optic nerve head scans from 9

231 ria and (2) ophthalmologist grading of optic disc photographs for characteristic features of glaucoma

232 Stereo disc photographs of 161 DH events from 83 OHTS participa

233 al coherence tomography (OCT), VF, and optic disc photographs were reviewed.

234 iber layer (RNFL) and macular OCT images and disc photographs with >2 years of follow-up and >=5 VFs.

235 e study with mean follow-up of 64 months, 20 disc photographs, and 16 VF tests.

236 Patients received optic disc photography every 3 months and VF testing every 4 m

237 A 21-year-old woman presented with optic disc pit in the right eye and optic disc coloboma with a

238 identified with a new presentation of optic disc pit maculopathy.

239 Stuffing of the optic disc pit with the ILM results in improvement of anatomic

240 performed at the temporal side of the optic disc pit.

241 c nerve and fovea and stuffed into the optic disc pit.

242 rces generate epithelial bending of the wing disc pouch.

243 nism by which cardiac-expressed intercalated disc protein Xinbeta modulates Hippo-YAP signaling to co

244 specific to 406W-desmin and to intercalated disc proteins.

245 ft and less displacement in the PPR within 1 disc radius (P < .0001) in adduction; the nasal hemi-dis

246 effective force increasing as the collective disc radius grows.

247 he lowest RNFL thickness and smallest cup-to-disc ratio (CDR), and Chinese Americans showed the large

248 .44-2.36; P < 0.001), larger vertical cup-to-disc ratio (per 0.1 unit; OR, 2.78; 95% CI, 2.12-3.64; P

249 f prematurity presented with enlarged cup-to-disc ratio and normal IOP.

250 e incidence of sustained worsening of cup-to-disc ratio by >=0.2 was 26% (95% CI 17%, 39%).

251 Advanced glaucoma was defined by a cup-to-disc ratio of 0.85 or higher in either eye.

252 The mean vertical cup-to-disc ratio was 0.66 (standard deviation [SD], +/-0.16) i

253 hickness) and 2018 (1 of 23: vertical cup-to-disc ratio).

254 corresponding baseline clinical data (cup-to-disc ratio, central corneal thickness, and intraocular p

255 their pigmentation increased, and their oral discs readily expanded.

256 ies, including tissue-engineering toward TMJ disc regeneration.

257 um showed irregular, convoluted intercalated disc regions, loss of contractile elements with disrupte

258 ude that the single source of Hh in the wing disc regulates cell type-specific responses in three dis

259 as observed in the nasal sector of the optic disc, remnant of fetal vasculature on the optic disc (Be

260 ured with BMP4 on extracellular matrix micro-discs, reproducibly differentiate into gastruloids, expr

261 tigated how epithelia of the Drosophila wing disc respond to loss of Short stop (Shot), a cytoskeleta

262 ial part of the trafficking pathway for both disc (rhodopsin) and rim (PRPH2/ROM1) components of the

263 is of early glaucoma, both macular and optic disc scans should be used.

264 High-frequency ODH within optic disc sectors, equivalent to detecting ODH in 45% of 3 mo

265 g macromolecules through a central pore of a disc-shaped hexamer.

266 ophobic shielding in the aggregates of these disc-shaped molecules is proposed to be best obtained by

267 ies reveal an evolution from a butterfly- to disc-shaped pattern and an increase in the correlation-l

268 ius (P < .0001) in adduction; the nasal hemi-disc shifted 24.5 +/- 1.3 mum compared with 4.4 +/- 2.1

269 In abduction, the young temporal hemi-disc shifted 4.4 +/- 0.6 mum nasally without significant

270 sample testing within a single biodegradable disc, simple design and fabrication techniques, potentia

271 This difference remains after accounting for disc size and AL.

272 f the coatings was evaluated using a ball-on-disc sliding test and demonstrated an excellent wear/fri

273 f certain phenolic compounds in various leaf discs suspended and cell-free extracts.

274 n electron microscopy (TEM) on wing imaginal discs temporally depleted of the ESCRT-III core componen

275 to induce the rotation of a disposable stir disc that causes chaotic mixing of glass beads ("MagVor"

276 n the region of the Drosophila wing imaginal disc that produces Hh and is near the tracheal air sac p

277 undead" model) in larval Drosophila imaginal discs that are attached by numerous macrophages.

278 Here, we present a new analysis platform (DISC) that accelerates unsupervised analysis of single-m

279 istinctly Inherited Set Comparison distance (DISC), that are specifically designed to account for the

280 The device is a simple spinning disc to estimate the parameters such as hematocrit, hemo

281 We apply CASet and DISC to multiple simulated datasets and two breast cance

282 Here, we use the developing Drosophila wing disc to systematically investigate, in a single epitheli

283 e where it spans half a sarcomere from the Z-disc to the M-band and is essential for muscle organisat

284 ssection from Drosophila larval eye imaginal discs to identify FoxO targets that restrict the prolife

285 Optic disc-to-tumor distance was the only variable associated

286 Whereas self-propelled hard discs undergo motility-induced phase separation, self-pr

287 Corporation, College Station, TX, USA), Meta-DiSc (version 1.4 for Windows; Cochrane Colloquium, Barc

288 The median distance to the optic disc was 3.0 mm, and that to the foveola was 2.0 mm.

289 The disc was partitioned into 8 sectors to match 8 visual fi

290 Given the flexible and efficient nature of DISC, we anticipate it will be a powerful tool for unsup

291 An additional 5 corneoscleral discs were also placed in the same medium and served as

292 Collagen membrane discs were implanted under the scalp in diabetic (strept

293 Acid-etched Ti discs were inoculated with human peri-implant plaque bio

294 ssociation, single cells reseeded onto micro-discs were motile and aggregated with the same but segre

295 Structural changes within intercalated discs were revealed by the abnormal organization of desm

296 cal environment of degenerating intact human discs where a single dose improved disc matrix homeostas

297 ome ganglion cell axons stalled at the optic disc, whereas others perforated the retina, separating p

298 The average ECD of the 30 corneoscleral discs, which later underwent stripping, was 2,292 +/- 30

299 optic stalk into the third instar larval eye disc while the photoreceptor cells (PR) are differentiat

300 n skeletal muscle, DNAJB6 localizes to the Z-disc with HSP70.