ライフサイエンスコーパス: discover

1 n tissue regeneration (MCTRs), were recently discovered.

2 t and parasite interact remain largely to be discovered.

3 Effective therapies have yet to be discovered.

4 ts to evolution and disease are likely to be discovered.

5 for known applications, and those yet to be discovered.

6 ists or as inverse agonists/antagonists were discovered.

7 cterial genomes and regulatory systems to be discovered.

8 ocyclizations with tetrahydrofuran have been discovered.

9 of MOFs in the form of hydrates is yet to be discovered.

10 the biguanide drug metformin are still being discovered.

11 ry P2X4 and/or P2X7 receptor inhibition were discovered.

12 key drivers of these pathways are just being discovered.

13 the function of the other two remains to be discovered.

14 among female participants and athletes were discovered.

15 re pathogenic repeat expansions remain to be discovered.

16 r more than half such disorders remain to be discovered(1).

17 lysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87

18 Although this organelle was discovered 120 years ago, such basic questions as whethe

19 set of MCH neurons where no connections were discovered [15], we used quadruple whole-cell recordings

20 Here, we discover 17 CSMN-enriched microRNAs (miRNAs), 15 of whic

21 f this library for growth in human serum and discovered 178 mutants with significant abundance change

22 sociation meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously be

23 563,085 European ancestry participants, and discover 5,106 new genetic variants independently associ

24 We discovered 6 clinical isolates from patients with asperg

25 lthough over a hundred FRB sources have been discovered(8), only four have been localized and associa

26 owing experiments, the RL agent was shown to discover a control strategy that is comparable to the op

27 We also discover a distant (25 angstrom) ligand-binding site uni

28 Hence, we sought to discover a druggable downstream transcriptional target o

29 ctivated by ultrasonic pup vocalizations and discover a functional synaptic network embedded through

30 2032 SLE patients, and healthy controls, and discover a low-frequency functional haplotype strongly a

31 Prior efforts to discover a useful sortase inhibitor have relied upon an

32 targeted metabolomics and RNA sequencing, we discovered a biosynthetic gene cluster in tomato (Solanu

33 We discovered a compact set of biomarkers with significant

34 We then used unbiased proteomics and discovered a critical role for emc1 in WNT signaling.

35 Despite this conservation, we unexpectedly discovered a disparate distribution for rhamnogalacturon

36 We have discovered a distinct mode of interaction through which

37 We discovered a distinct population of GABAergic neurons ac

38 We discovered a domain in OtDUB with Rac1/Cdc42 GEF activit

39 Using X-ray crystallography, we have discovered a domain-swap homodimerization mode in CYP51

40 loci data.Measurements and Main Results: We discovered a genomic region at 1q32 that was significant

41 In a genetic screen, we discovered a large number of endolysosomal trafficking g

42 rformed robotic cancer cell line screens and discovered a marked sensitivity of hematological cancer

43 Herein, we discovered a near-infrared fluorophore with inherent kid

44 Using an enhancer trapping assay, we discovered a novel osmosensitive mechanism by which intr

45 Here, we discovered a novel size law that connects cell size to t

46 immortalized mouse embryonic fibroblasts and discovered a number of cellular defects, which are rever

47 series of elegant mouse studies, the authors discovered a pathway linking increased G-3-P to increase

48 no fully invariant OMA-selective neuron, we discovered a population code that allowed us to classify

49 Overall, we have discovered a previously unrecognized role of Pdcd4 in co

50 the detrimental role of periostin in CKD, we discovered a protective role of periostin in AKI.

51 ed biosensors in patch clamp experiments, we discovered a robust voltage dependence of the thromboxan

52 ional screening, genetics, and proteomics we discovered a strain of Staphylococcus capitis (S. capiti

53 ave taught us that there is still much to be discovered about this system.

54 r negative-mode MS(2) affords an easy way to discover additional O-glycosylations on a multiply glyco

55 We discovered additional changes in aging, as glandular-lik

56 ogenic drivers for specific cancer types are discovered along with their associated risks.

57 We discover an expansion of odorant-binding-protein genes,

58 Kountz et al have discovered an alternative pathway for carnitine metaboli

59 In previous work, we discovered an elevated expression of 14-3-3 proteins in

60 Here, we discovered an unanticipated and sole role for spermine i

61 lethalities in OVCAR8 and A375 cancer cells, discovering an interaction between MARCH5 and WSB2.

62 We discovered anaplastic lymphoma kinase (ALK) as a candida

63 Here, we discover and validate four mosaic structural variants (S

64 In a case study, we discovered and experimentally validated new transcripts

65 ci and various traits have been successfully discovered and published for the model plant Arabidopsis

66 Recently, we discovered and validated the plasmodial l-lactate transp

67 utes to the field of antiviral immunology by discovering and characterizing a novel restriction facto

68 a industry and its established processes for discovering and developing new medicines.

69 eployed three mobile laboratories during the DISCOVER-AQ campaign in summer 2014 with a focus on nort

70 to understand endocrine drug resistance, we discovered ARID1A and other SWI/SNF complex components a

71 its pole-to-pole orbit, the Juno spacecraft discovered arrays of cyclonic vortices in polygonal patt

72 3E) is a secreted protein that was initially discovered as a neuronal guidance cue.

73 developed compounds but also compounds newly discovered as contaminants in the environment.

74 Researchers have discovered associations between elements of the intestin

75 a time-stamped benchmark containing 42 newly discovered associations.

76 ences in crystallization characteristics are discovered between ITIC-2F and ITIC-2Cl.

77 Significant differences in CTRP1 levels were discovered between the single- and triple-vascular-vesse

78 variety of screening methods in an effort to discover binders of PrP, including (19)F-observed and sa

79 ed to use non-targeted urine metabolomics to discover biomarkers and improve risk prediction for T2D.

80 tures learned from these methods are used to discover both technical artifacts and novel biological p

81 mutations from >8200 tumor-normal pairs, we discover broad genic repression domains (BGRD) on chroma

82 e EPAC isoform 1 (EPAC1), I942, was recently discovered, but its mechanism of action remains poorly u

83 numerous types of defense systems have been discovered, but there is no comprehensive defense system

84 Secretagogin (SCGN) is a recently discovered calcium-binding protein belonging to the grou

85 le-cell TCR sequencing in a third cohort, we discovered clonally expanded CD8(+) T(EMRA) cells in the

86 s C virus (HCV)-host interactions, one could discover common strategy for inhibiting the replication

87 ar niches, as well as in the number of newly discovered compartments.

88 ul technique to study these materials and to discover complex correlations.

89 putational models to incorporate these newly-discovered components.

90 of the human eye and thus can be utilized to discover defects in vitamin A metabolism during the rege

91 Moreover, PSID discovered distinct rotational dynamics that were more p

92 To discover driver fusions beyond canonical exon-to-exon ch

93 cer, which brings a potential opportunity to discover drugs that target cancer cell metabolism.

94 We discover eight novel loci associated with SCC, confirm a

95 Discovering endogenous mechanisms for reducing pain and

96 in a mouse model of Parkinson's disease, we discovered evidence for an upregulation of the oxygen ho

97 tic tools for cell-specific manipulation, we discovered excitatory neurons that induce nausea-related

98 We discover exponentially decaying spatial modes in both he

99 Here we discover extensive mixed tailing in transcripts of hepat

100 Using a Notch reporter mouse, we discovered FCSCs localized within the TMJ superficial ni

101 The recently discovered flat electronic bands and strongly correlated

102 Plant TA is discovered for the first time in the plant kingdom and i

103 unique attributes of several of these newly discovered FPs, we expect that Aequorea will, once again

104 rating these large-scale multiomics data and discovering functional insights are, nevertheless, chall

105 The only recently discovered gem-hydrogenation of internal alkynes is a fu

106 and/or interaction effect are often used to discover Gene-Environment (GxE) interactions.

107 In this study, we discovered glycine as a simple additive for TFA mobile p

108 unnelling microscopy studies of the recently discovered heavy-fermion superconductor UTe(2), which ha

109 of LPHAMS, we characterized one of the newly-discovered heparin-binding proteins, C-type lectin 14a (

110 f a complete set of cation derivatives is to discover highly stable cations, which are further integr

111 We discovered highly sensitive dysregulation of TBX5-depend

112 We discovered HLA risk factors and four non-HLA susceptibil

113 erastin-induced cellular resistance, we can discover how cells adapt to new molecules to maintain ho

114 This work lays a foundation for discovering how the brain represents and computes with d

115 The authors discovered human-unique expansion and maintenance of cer

116 This recently discovered illusion-the reverse Pulfrich effect-is cause

117 ion between phenacyl bromides and indoles is discovered in a highly regioselective fashion to furnish

118 lated partitivirus, verdadero virus, that we discovered in a laboratory colony of Aedes aegypti mosqu

119 miR-19b, miR-20a, miR-451a and miR-92a) were discovered in both humans and mice.

120 K-PPn was originally discovered in budding yeast (Saccharomyces cerevisiae),

121 Initially discovered in Drosophila, the Hippo pathway has been imp

122 In 2015, the mcr-1 gene was discovered in Escherichia coli in domestic swine in Chin

123 This was indeed discovered in experiments which however revealed an intr

124 ural and medicinal importance, have now been discovered in plant genomes.

125 lf (Canis lupus) pup (specimen YG 648.1) was discovered in thawing permafrost in the Klondike goldfie

126 In recent years, carbon black has been re-discovered in the design of electrochemical (bio)sensors

127 passing all amyloid fibril structures so far discovered in the PDB.

128 l to derive mechanistic hypotheses for newly discovered inhibitors.

129 Three heat storage-release schemes were discovered involving different activation methods (optic

130 In addition to reducing model complexity and discovering key biomarkers, feature selection is also an

131 A recently discovered light-molecule interacting phenomenon, suprac

132 We sought to discover linked patterns of covariation between brain st

133 At the same time, recently discovered long-range intrinsic magnetic orders in the t

134 Here, we discover lysis inhibition in the etiological agent of th

135 often a critical operation in the pathway to discovering materials with novel functions.

136 Each of these three recently-discovered mechanisms of the Dorsal module are critical

137 -matched on BMI, age, and race/ethnicity) to discover metabolites associated with new onset of T2D.

138 TMA, carnitine is demethylated by the newly discovered methyltransferase MtcB, sending one-carbon un

139 generate transient electrical currents first discovered more than 30 years ago.

140 poly(ADP-ribose) polymerase 1 (PARP1), were discovered more than 50 years ago.

141 Our results implicate a newly discovered, multidimensional MAPK7/MMP9 signalling hub i

142 ta pooling to increase the confidence in the discovered mutations, moves the discovery back in the pa

143 points to it as a sixth variety of yet to be discovered natural melanin.

144 elling, biomarker potential and the recently discovered ncRNA-derived micropeptides.

145 In this review, I discuss newly discovered neuronal circuits in primates that represent

146 We discover new functional synergies between TNF and IFNbet

147 hogenic, and commensal-and an opportunity to discover new ways to treat microbial-driven diseases.

148 roved assembly of segmental duplications, we discovered new lineage-specific genes and expanded gene

149 nt dynamics at the meso-nanosecond scale and discovered new spatter-induced defect formation mechanis

150 Discovering new deep-ultraviolet (DUV) nonlinear optical

151 as a source of luciferase, and the recently discovered non-luminescent cave worm Neoditomiya sp as t

152 formatics workflow for using RNA-seq data to discover novel alternative splicing biomarkers from the

153 cessfully with the opioid crisis, we need to discover novel analgesics whose mechanisms do not involv

154 tic lethality is an innovative framework for discovering novel anticancer drug candidates.

155 The newly-discovered NSC-BV communication route explains how circu

156 re not associated with clinical response, we discovered numerous chromosomal alterations associated w

157 SCCs are microvillous cells that were first discovered on the skin of fish, and later in amphibians,

158 Newly discovered oncohistone mutations include lysine-to-methi

159 lated changes, many of which are still to be discovered or refined.

160 omic profiles and used epistasis analysis to discover parallel networks centered on CHD8*chd-7 and NL

161 Discovering phage genes that exclude superinfecting phag

162 nd Random Forest classification were used to discover potential biomarkers and selected biomarker mod

163 f these groups will guide ongoing efforts to discover potential risk factor and assist with future tr

164 Here, we discover prePAAR, a conserved motif found in over 6000 p

165 Next to the recently discovered pro-inflammatory role of cytosolic LPS, our d

166 We additionally discovered pro-viral genes and pathways, including HMGB1

167 Happe and Morley (2004) discovered prominent expression of alpha7 nAChRs in rat

168 spectrometry we confirm expression of newly-discovered proteins on the cell surface in vivo.

169 -, UbiV-, and UbiT-dependent manner has been discovered recently in E. coli Its physiological relevan

170 own as KDM1A), the first histone demethylase discovered, regulates cell-fate determination and is ove

171 ng, we implemented a comprehensive screen to discover regulators of (i)Mg(2+) dynamics.

172 in situ cell-surface proteomic profiling in discovering regulators of brain wiring.

173 isms, and finally the nature of the recently discovered role of astrocytes within the SCN network.

174 endent activity uncover putative or recently discovered roles for at least five regulons, such as a r

175 mical biology, pharmacology, and medicine to discover safe and efficacious drugs.

176 gh-throughput in vivo screening platform and discover several driver variants of PIK3CA.

177 nonlinear Support-Vector Regression. We also discovered several previously unknown odorants activatin

178 As such, discovering signaling pathways that modulate albuminuria

179 Here, we discovered site-specific fragmentation of NOTCH3 protein

180 This study aimed to discover small-molecule inhibitors targeting RANKL trime

181 tion site associated DNA (RAD) sequencing to discover SNPs in samples from four contact zones between

182 pe of fecundity genes in goats have not been discovered so far.

183 nhibitory function of sulfonamides on CA was discovered some 80 years ago.

184 Although the ferrocenium cation was discovered soon afterwards, a derivatized ferrocenium di

185 We discover that analysis in the frozen-hydrated state yiel

186 which they delete Lmna in cardiomyocytes and discover that bromodomain and extraterminal (BET) protei

187 Here, we used a reconstitution system to discover that Cdk1, the major mitotic kinase that drives

188 Herein, we discover that certain protein could efficiently prevent

189 In this report we discover that genetic deletion of Gravin disrupts proper

190 We discover that HELLS facilitates homologous recombination

191 associated herpesvirus (KSHV) biology helped discover that KSHV infection hijacks the proinflammatory

192 Through LC-MS/MS analysis, we discover that majority of miR-21-5p isolated from human

193 We discover that maturation of the microbiota drives the de

194 Sun et al. discover that neuronal firing rates of hippocampal place

195 We discover that P1 neurons, active during courtship, are i

196 our methodology to the city of Singapore we discover that parking infrastructure reduction of up to

197 Finally, we discover that Polycomb-mediated gene repression requires

198 ispersed Rh on N-doped carbon (SA-Rh/CN) and discover that SA-Rh/CN exhibits promising electrocatalyt

199 However, we discover that short guide RNAs can also support base edi

200 (2020) discover that the C-terminal substrate-binding domain of

201 lapse imaging of primary resected tumors, we discover that tumor-derived oRG-like cells undergo chara

202 We discovered that 2 crustacean cardioactive peptide (CCAP)

203 We discovered that a dominant, phenotypically stable, CXCR5

204 Using deep sequencing approaches, we discovered that a member of the Cnidaria, the myxozoan H

205 We discovered that a subset of non-small cell lung cancer c

206 Strikingly, we discovered that ACE2 is a human interferon-stimulated ge

207 We have further discovered that Akt inhibition or a specific small-molec

208 Here we discovered that an independently derived, lab-selected C

209 hing cells in the nasal mucosa, moreover, we discovered that Ascl-1 is necessary for GnRH-1 ontogeny.

210 We discovered that ASFV infection had only a modest effect

211 ic in vitro transcription assay, we have now discovered that backbone interactions between the amino

212 istance to measure probabilistic changes, we discovered that brain regions in the default mode networ

213 We discovered that breast-cancer-derived lung metastases, b

214 However, we discovered that bursting alone cannot quantitatively rec

215 roxy-L-proline (Hyp) dehydratase (HypD), was discovered that catalyzes the dehydration of Hyp to (S)-

216 we conducted glycan microarray analyses and discovered that CHIKV preferentially binds GAGs.

217 In contrast, we discovered that chromosomal instability activates cGAS/S

218 Recently, we discovered that cohesin SA1 and SA2 are DNA binding prot

219 We discovered that contractile rings in cps1-191 cells cons

220 Here, we discovered that Cryptococcus cells polyploidize in respo

221 g an MMTV-PyMT mouse mammary tumor model, we discovered that deletion of TGFbeta signaling on myeloid

222 We discovered that during ligule development, the E class M

223 We unexpectedly discovered that DX314, but not all-trans-RA or previous

224 We also discovered that Fabp5, an abundant cytoplasmic lipid-bin

225 We also discovered that formative TF target genes are marked by

226 In this study, we discovered that FUS was acetylated at lysine-315/316 (K3

227 Unexpectedly, we discovered that G. stearothermophilus T-1 can also utili

228 Additionally, we discovered that hepatocytes displayed malfunctioning bet

229 This study discovered that IkappaBzeta is strongly induced in kerat

230 genomic estimates of realized inbreeding, we discovered that inbred individuals had lower survival pr

231 We discovered that inclusion of the positively charged A1 i

232 We discovered that increases in the provider COCI were sign

233 Previously, we discovered that influenza-generated CD4 effectors must r

234 Interestingly, we discovered that intrabody sensors can also report betaar

235 Here, we discovered that Kruppel-like factor 6 (KLF6) governs mac

236 resolution tandem mass spectrometry, we have discovered that mature frataxin in mouse heart (77%), br

237 We discovered that MDFI is up- and MDFIC downregulated in c

238 In this study, we discovered that mechanical stimulation of integrin beta1

239 We also discovered that MrgprA3(+) neurons respond to skin derma

240 F2 plants segregating for the Ptr1 locus was discovered that narrowed the Ptr1 candidates to eight nu

241 We also discovered that outlier values of SkewIT highlight poten

242 We discovered that P-wave velocities track where a porosity

243 We discovered that PEBP1 is pivotal to driving dynamic inte

244 Here, we discovered that PRL2 ablation inhibits PTEN heterozygosi

245 high glycolytic demand of skeletal cells, we discovered that S. aureus requires glycolysis for surviv

246 Netropsin is one of the first ligands to be discovered that selectively binds to the minor groove of

247 In recent follow-up studies, we discovered that sensitivity to tiopronin in the original

248 We discovered that sleep-wake brain states and motor behavi

249 e the GH receptor in vitro In this study, we discovered that substitution of p.Cys-53 in hGH signific

250 cleobase determinants of 5mC recognition, we discovered that TET enzymes are also proficient as direc

251 We discovered that the adaptive immune response against Sta

252 Furthermore, we discovered that the BARLEY B RECOMBINANT/BASIC PENTACYST

253 Here, we discovered that the binding between SNX-BARs and CI-MPR

254 the C. jejuni butyrate-modulated regulon and discovered that the BumSR two-component signal transduct

255 al genetic knockout mouse models, we further discovered that the E3 ubiquitin ligase Nedd4 is require

256 We discovered that the efficiency of the NCLP (N-RNA) assem

257 We discovered that the enzyme target [Acanthamoeba castella

258 We discovered that the human window of implantation opens w

259 We discovered that the mechanical integrity of LiF is easil

260 Moreover, we discovered that the normal invigoration of female-direct

261 Surprisingly, we discovered that the often-found processing advantages fo

262 We discovered that the permittivity of the film was non-uni

263 In the course of our studies, we discovered that the repressor domain SID (SIN3-interacti

264 We discovered that the S1pr2 absence is linked to an impair

265 In the absence of the sulfone groups, we discovered that the tetrahedral linker directs the forma

266 ges lodged within the healthy myocardium, we discovered that they actively took up material, includin

267 In earlier work, we discovered that through the activities of the viral prot

268 We discovered that two recurring folds were central to the

269 Recently, we discovered that WD repeat-containing protein 5 (WDR5) bi

270 X-ray absorption spectroscopy analysis discovered that zerovalent Cr(0) coexisted with trivalen

271 We discovered that ~94% of recently collected isofemale lin

272 rivascular flow model is solved numerically, discovering that the peristaltic wave induces a steady s

273 ral networks [1], are introduced and used to discover the underlying dynamics of biological systems f

274 For the first time, we discovered the importance of multivalency in the PML II-

275 le attempting to synthesize biaryl ethers we discovered the inadvertent formation of a methylsulfoxyl

276 We also discovered the locus-locus interaction of DNAm levels of

277 We discovered the polarization of cristae and crista juncti

278 A crucial aspect when learning a language is discovering the rules that govern how words are combined

279 es, great progress has recently been made in discovering the structural subcomponents and proteins im

280 Overall, it was discovered there was some variation between the differen

281 n increasing number of circadian genes being discovered, there is a pressing need for methods facilit

282 However, current approaches to discover these anchors from HiChIP data are not satisfac

283 Astronomers have discovered thousands of planets outside the Solar System

284 Genome-wide association studies (GWAS) have discovered thousands of significant genetic effects on d

285 We discover three causal SNPs of EPAS1, the key adaptive ge

286 roelastic twin boundaries have been recently discovered to exist in both CH(3)NH(3)PbI(3) thin films

287 ydroxy-2H-chromen-2-one; BHC) was previously discovered to inhibit skeletal myosin II.

288 e galiellalactone (1) was, as its acetate 4, discovered to undergo a substitution reaction with cyste

289 Focusing on the mammillary bodies (MB), we discovered transcriptionally-distinct clusters that exhi

290 shared very similar properties, but we also discovered transcriptomically related neurons with speci

291 The need to discover treatment modalities for COVID-19 is a necessit

292 We discovered unique genes expressed by pigment cells and t

293 scale imaging and computational analysis, we discovered unique spatial designs comprising mixed inter

294 lternative Open reading frame (AltORFs) were discovered using customized databases.

295 nipulate the magnetic properties in recently discovered van der Waals ferromagnets is essential for t

296 eR successfully extracted hub regulators and discovered well-known risk genes.

297 multicellular animals, it is of interest to discover when and how this machinery arose during evolut

298 ediated hydrazine coupling reaction was also discovered, which provided a selective pathway to synthe

299 ations and, consequently, limits what can be discovered with subsequent analyses.

300 which, once discovered, would have become an indispensable part of d