ライフサイエンスコーパス: disease-related

1 rtib group and 31 in the placebo group) were disease related.

2 licated in CHD had >70% probability of being disease related.

3 he more stable amyloid state, which is often disease-related.

4 (PTEN-induced kinase-1)-, PDR-1 (Parkinson's disease-related-1; parkin)-, or DCT-1 (DAF-16/FOXO-contr

5 ximab-chemotherapy group died (4 deaths were disease-related, 3 were treatment-related, and 1 was fro

6 wide range of biological processes and their disease-related aberrations.

7 Insight into the complete landscape of disease-related abnormalities and the context in which t

8 ced adrenergic drive plays a central role in disease-related activation of the channels.

9 e found in multivariable analysis, including disease-related (acute leukemia, curative intent chemoth

10 ; 91 mitral disease-related AF, 30 nonmitral disease-related AF) and from 39 patients in sinus rhythm

11 (group 1; 59 males; 60+/-11 years; 91 mitral disease-related AF, 30 nonmitral disease-related AF) and

12 Hence, unraveling the disease-related alteration of glycosylation, especially

13 f candidate genes that demonstrate congruent disease-related alterations across the different data ty

14 ain connectivity: to obtain insight into how disease-related alterations at one level of organization

15 for better understanding and predicting the disease-related alterations in microbial communities.

16 nts, with an increased potential to identify disease-related alterations in their biomolecular compos

17 t to impair the transport of the Alzheimer's disease-related amyloid precursor protein (APP), althoug

18 or longer with regard to progression of nine disease-related and clinically meaningful mobility and u

19 Also, to examine associations with disease-related and sociodemographic factors among those

20 essions were used to explore associations of disease-related and sociodemographic factors with future

21 20 in the chemotherapy group (17 deaths were disease-related, and 3 were treatment-related) (hazard r

22 q is a powerful tool to study developmental, disease-related, and age-related changes in the gene exp

23 lowing categories: demographic, behavioural, disease-related, and psychosocial factors.

24 matic weight reduction, suggesting a role in disease-related anorexia.

25 ase and accumulation of SARS-CoV-2-specific "disease-related" B cell populations.

26 They both are Alzheimer's disease related biomarkers, indicating the potential and

27 opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in

28 Cancer is the leading disease-related cause of death in children in developed

29 Burkitt published an article titled "Related disease-related cause?", which became the foundation for

30 with very high under-5 mortality, infectious-disease-related causes (pneumonia and diarrhoea) were am

31 ore the power of using pathogens to discover disease-related cell biology.

32 s and cardiomyocytes, but not fibroblasts or disease-related cells.

33 e to assess carotenoid status and highlights disease-related changes and potential nutritional interv

34 al effects for age- and/or neurodegenerative disease-related changes in arousal and sleep.

35 e requires an understanding of the timing of disease-related changes in tau.

36 kely contributes to neuron and synapse loss, disease-related changes to oligodendrocytes and myelin a

37 Those with Alzheimer's disease-related cognitive impairment were younger, more

38 Further disease-related common genetic variability remains to be

39 that can be used to diagnose PSC and detect disease related complications.

40 Long-term follow-up studies regarding disease-related complications and outcome are scarce.

41 At each visit, liver disease-related complications, treatment modifications,

42 orbidities, increased risk of infections and disease-related complications.

43 s important to identify patients with severe disease-related damage who should avoid pregnancy, couns

44 andardized genetic, genomic, phenotypic, and disease-related data for eight species, and a suite of i

45 ity networks from diverse lncRNA-related and disease-related datasets, then implements the random wal

46 of hepatocellular carcinoma (HCC) and liver-disease related death, in association with metabolic ris

47 The cumulative incidence of disease-related death (CIDD) was the primary end point,

48 o calculate county-level, age-adjusted liver disease-related death rates.

49 ctions are a major contributor to infectious disease-related deaths across the globe.

50 tions [MIs], 95 CHD deaths), 57 had other CV disease-related deaths, and 215 had heart failure (HF).

51 have been informative in predicting age- and disease-related decline in cardiovascular health, but fe

52 ling axis holds promise for slowing age- and disease-related degeneration of NMJs.

53 nonsmokers, and present for both Alzheimer's disease-related dementia and cerebrovascular etiologies.

54 , and increases vulnerability to Alzheimer's disease-related dementias.

55 Thus, we aimed to characterise the trends in disease-related dietary factors as well as their associa

56 We demonstrate disease-related differences in mitochondrial integrity i

57 d provides a valuable resource for assessing disease-related disruptions.

58 e subjects revealed both shared and distinct disease-related effects on gene expression between cell

59 of fibrosis, we measured pharmacodynamic and disease-related end points.

60 e performance of the prediction modeling for disease-related entity, but not on the clinical implicat

61 enetic components of the infectious agent or disease-related epitope.

62 ochondrial and enzyme defects predominate as disease-related etiologies.

63 We compared the incidence of disease-related events and cumulative spending at 90 day

64 ted deaths combined with life-saving aborted disease-related events was 6.4%/year, 3-fold greater tha

65 events, potential immune-mediated diseases, disease-related events, and fatal serious adverse events

66 Disease-related factors (e.g. symptom severity, duration

67 U, we evaluated associations of maternal HIV disease-related factors during pregnancy with risk of ch

68 s, we evaluated associations of maternal HIV disease-related factors during pregnancy with risk of ch

69 OPD patients is more likely a consequence of disease-related factors rather than a cause of the disea

70 quires careful consideration of patient- and disease-related factors to decrease the risk of acquirin

71 he magnitude of risk and its relation to HIV disease-related factors, including CD4 count and viral l

72 valence and patient, health care system, and disease-related factors.

73 omes after controlling for socioeconomic and disease-related factors.Methods: Using the Sarcoidosis A

74 erity of MI, symptoms, and comorbidities for disease-related factors; anxiety and depression for psyc

75 erned stimulation, mostly controlled through disease-related feedback.

76 ties of microbes with weak associations with disease related gene expression.

77 ated the capability of AAV2.retro to deliver disease-related gene cargo to biologically-relevant NHP

78 Transcriptome analysis revealed distinct disease-related gene expression profiles depending on an

79 iologically sensible findings, including the disease-related gene expressions, copy number variations

80 RPS6 is a potential novel disease-related gene.

81 ed mice provides resources to identify novel disease-related genes and pathways.

82 hod to an AD dataset, and identified several disease-related genes and processes demonstrating the us

83 , we find that some subsets are enriched for disease-related genes and RNA signatures.

84 s are liable to affect the functions of core disease-related genes and that most heritability can be

85 for moving toward a more complete catalog of disease-related genes and variants.

86 ession changes in enteric neurons, show that disease-related genes are dysregulated with aging, and i

87 line settings might be used to help identify disease-related genes by guiding the development of back

88 UDEP, epilepsy, heart disease or respiratory disease-related genes from previous published reports an

89 rimental data suggest that BFDCA can cluster disease-related genes into functional DC subunits and es

90 dentified in macaque, and that expression of disease-related genes is largely conserved between the t

91 transcription factor targets to identifying disease-related genes to causality inference.

92 bunits and estimate the regulatory impact of disease-related genes well.

93 eletions and one duplication) involved in 10 disease-related genes were selected for validation by us

94 An example of this is the analysis of disease-related genes within sub-populations of blood or

95 cused on studying G4s in promotor regions of disease-related genes.

96 approach is sufficient to discover groups of disease-related genes.

97 and carriers of the most common Parkinson's disease-related genetic mutations, which aims to define

98 have played an important role in identifying disease-related genetic variants and novel treatments.

99 his analysis, we concluded that 80% of known disease-related genetic variants are associated with cri

100 een an exponential increase in the amount of disease-related genomic data available in public databas

101 microglial elimination reduced or prevented disease-related grip strength and object recognition def

102 lian randomization-based method combining 58 disease-related GWA studies to derive longevity priors f

103 r, and in degree and duration of fatty liver disease-related hepatocellular carcinoma.

104 hether single-cell RNA sequencing can reveal disease-related heterogeneity within alveolar macrophage

105 luate differences in the incidence of common diseases, related hospital admissions, and related morta

106 timated glomerular filtration rate, a kidney disease-related hospitalization or death, or end-stage r

107 the decline observed in pediatric infectious disease-related hospitalizations in general.

108 ily a result of reduced risks for infectious disease-related hospitalizations.

109 me level of remission to restore generic and disease-related HRQoL and one's ability to work producti

110 rrespective of the mechanisms generating the disease-related hyperactivity, is a promising translatio

111 Greater Alzheimer's disease-related hypometabolism was observed in brain reg

112 disease primarily to IS, either intrinsic to disease-related immune compromise or from the extrinsic

113 We detected an age- and disease-related increase in monocyte recruitment into Dy

114 zed by keratinocyte hyperproliferation and a disease-related infiltration of immune cells.

115 When more reliable drug- or disease-related information becomes available and is int

116 h, healthcare-delivery, and other infectious diseases-related institutions play a central role in mee

117 h age and render aging neurons vulnerable to disease-related insults.

118 d novel Internet-based data sources, such as disease-related Internet search activity, can produce me

119 storical epidemiological data available with disease-related Internet search activity, we retrospecti

120 ighly curated and user-friendly platform for disease-related knowledge.

121 1-CDG and was shown to markedly reverse most disease-related laboratory abnormalities.

122 that predisposes individuals to dystonia, a disease-related level that is evident only when dystonia

123 -disease associations will gain insight into disease-related lncRNAs and benefit disease diagnoses an

124 fective computational approaches to identify disease-related lncRNAs are in high demand; and would be

125 effects are a result of cell-wide changes or disease related locus specific effects is unknown.

126 By reconstructing the evolution of the disease-related locus MLO2b, we find that divergence bet

127 tabolic demand and are susceptible to age or disease-related losses in oxygen and nutrient supply.

128 of the aging process and its cardiovascular disease related manifestations.

129 understand behavior, its regulation, and its disease-related manifestations.

130 rns, demonstrating its promise for improving disease-related mechanistic understanding.

131 Thus, it can be broadly used to identify disease-related microbial organisms that are not well-st

132 following learning show increases in several disease-related microRNAs targeting the activin A recept

133 Experimental methods to determine disease related miRNAs are time consuming and costly.

134 and whether any association was affected by disease-related modification of the exposure or modified

135 ed modeling showed no consistent results for disease-related modification of the exposure.

136 ger microtubule organization and reveal that disease-related modifications of tau promote specific mi

137 We exposed primary cells to disease-related modifiers that alter epithelial morpholo

138 enium-shows age-related, region-related, and disease-related molecular signatures and may be importan

139 ystemic inflammation, weight loss, and other disease-related morbidities associated with poor prognos

140 h decreased muscle strength, contributing to disease-related morbidity.

141 factors associated with variability in liver disease-related mortality and hotspots of liver disease

142 illance of diseases can significantly reduce disease-related mortality and trauma.

143 ath; when treated, it is associated with low disease-related mortality, no different than for patient

144 Ps in 36 genes significantly associated with disease-related mortality, progression-free survival, tr

145 significant intrastate differences in liver disease-related mortality, with more than 60% of the var

146 screening for BE could potentially decrease disease-related mortality.

147 ressed protein, leading to the generation of disease-related multichain PrP assemblies that propagate

148 ccumulated in the distal axon of Alzheimer's disease-related mutant human APP transgenic neurons and

149 n of exogenously expressed wild-type FUS and disease-related mutant R514G was observed.

150 Disease-related mutations are mapped to the observed pro

151 ral and mutagenesis analyses suggest several disease-related mutations enhance channel activity by di

152 tions in the helical domain of Cya mimic the disease-related mutations in human proteins, recapitulat

153 past decade have revealed a large number of disease-related mutations in the MEK1 gene that lead to

154 encing make it possible to identify multiple disease-related mutations, but there is currently no sys

155 ), here we explored the relationship between disease-related mutations, LLPS, and tau fibrillation.

156 ents with YOPD who have no known Parkinson's disease-related mutations, suggesting that there might b

157 iological functions of CCCs and interpreting disease-related mutations.

158 especially dramatic for tau441 variants with disease-related mutations.

159 logical strategies hold promise for tackling disease-related networks.

160 pecialization, and potentially responding to disease-related neuronal dysfunction.

161 te that temporal topic trends extracted from disease-related news reports successfully capture the dy

162 elopment as well as the functional impact of disease-related noncoding genetic variants.

163 ut fibril architecture, atomic structures of disease-related oligomers have eluded determination.

164 Disease-related or treatment-related limitations in acti

165 All studies that reported a disease-related outcome (local recurrence, nodal metasta

166 Risks of disease-related outcomes and 5-year recurrence-free, dis

167 ent, as EF deficits are associated with poor disease-related outcomes and psychosocial functioning.

168 Evidence-based estimates of the risks of disease-related outcomes comparing IPNI and CPNI are lim

169 er, in this study, denosumab did not improve disease-related outcomes for women with high-risk early

170 tion analysis of microbiome composition with disease-related outcomes provides invaluable knowledge t

171 Overall risks of disease-related outcomes were generated by pooling patie

172 ntial implications for immune and infectious-disease-related outcomes.

173 r characteristics, treatments performed, and disease-related outcomes.

174 t tests were used to evaluate differences in disease-related outcomes.

175 ity on access to care, use of resources, and disease-related outcomes.

176 species is clinically meaningful for finding disease-related pathogenic or probiotic bacteria.

177 in mitochondrial dysfunction and Alzheimer's disease-related pathological and cognitive impairments i

178 pivotal role of this organelle, and PC1, in disease-related pathological cardiac remodeling and sugg

179 beta (TGF-beta) signaling promotes Parkinson disease-related pathologies and motor deficits, and incr

180 his regard, new evidence linking Alzheimer's disease-related pathology and neuronal stem cells sugges

181 teral sclerosis who lacked neurodegenerative disease-related pathology outside of the motor system.

182 Abrogation of disease-related pathology was also evident, with reducti

183 mal pathology at early stages of Alzheimer's disease-related pathology.

184 This disease-related pattern of findings was also identified

185 linically discordant for MS and searched for disease-related peripheral immune signatures in a system

186 discover that nicotinamide (NAM) ameliorated disease-related phenotypes by inhibiting drusen proteins

187 netic and environmental contributions of 560 disease-related phenotypes in 56,396 twin pairs and 724,

188 ear magnetic resonance (NMR) metabolomic and disease-related phenotypes in a mouse F2 cross derived f

189 Alzheimer's disease-related phenotypes in mice can be rescued by blo

190 Targets, cover human de novo gene variants, disease-related phenotypes in model organisms, and a bio

191 genetic correlations among 30 behavioral and disease-related phenotypes measured in the UK Biobank (U

192 e longevity GWA results with that of several disease-related phenotypes points to a shared genetic ar

193 ed formalism also associates combinations of disease-related phenotypes with inferred disease pathway

194 with neuronal loss of Tsc2 that demonstrates disease-related phenotypes, including behavioral symptom

195 n living patients, enabling the discovery of disease-related phenotypes.

196 g genetic and environmental contributions to disease-related phenotypes.

197 f the disease variants across a panel of the disease-related phenotypes.

198 hese deficiencies may result from disease or disease-related physiological processes.

199 e potential information of piRNA targets and disease related piRNA.

200 We examined wild-type SOD1 and six disease-related point mutants by using tandem MS and ion

201 however, little is known about the host- and disease-related predictors of these symptoms and their e

202 However, little is known about the host- and disease-related predictors of these symptoms and their e

203 The presence of abnormal, disease-related prion protein (PrP(D)) has recently been

204 pe) affords a unique insight into normal and disease-related processes and is a prerequisite for comb

205 also observed enrichment in other key heart disease-related processes like myocarditis, fibrosis, hy

206 and therapeutics targeting only Alzheimer's disease-related processes may have severely limited effi

207 -ranked neuronal subnetwork, and its role in disease-related processes was evaluated through CRISPR-b

208 Despite their importance in many disease-related processes, how these versatile structure

209 eurons, and thus prone to aggregation upon a disease-related progressive collapse of protein homeosta

210 ive aging to include evidence of Alzheimer's disease-related protein aggregation as an underlying mec

211 s, emphasizing the reciprocal roles in which disease-related protein and disease-related RNA can lead

212 road-reaching significance for understanding disease-related protein misfolding.

213 e potential to regulate the abundance of any disease-related protein.

214 mary nucleation in amyloid formation for the disease-related proteins Abeta40 and alpha-synuclein.

215 rtance of assaying the effects of transgenic disease-related proteins at appropriate stages in life.S

216 agy may also be involved in the clearance of disease-related proteins in astrocytes as well as in mai

217 ic acids can nucleate protein aggregation in disease-related proteins, but in other cases, they can a

218 ins and the amounts of insoluble Alzheimer's disease-related proteins, in particular amyloid-beta40,

219 CMA regulates the abundance of many disease-related proteins, with causative roles in neopla

220 thesized that of the three major Parkinson's disease-related proteins-alpha-synuclein, LRRK2, and Par

221 n part, independent of insoluble Alzheimer's disease-related proteins.

222 ear to act as a nidus for the aggregation of disease-related proteins.

223 29 of the prion protein, PrP, gene harboring disease-related PrP, PrP(D), types 1 and 2).

224 tem Asthma Control Questionnaire scores) and disease-related QoL (measured using the Asthma QoL Quest

225 is necessary to avoid misattributing malaria-disease-related QT changes to antimalarial drug effects.

226 how synapses decode a pattern of stimuli, a disease-related Ras allele abolished the spacing effect

227 termine whether primary cilia play a role in disease-related remodeling.

228 g, and the influence of coexisting host- and disease-related risk factors.

229 l roles in which disease-related protein and disease-related RNA can lead to disturbances in the mate

230 Because they carry specific disease-related RNAs and proteins, practical application

231 moteness was associated with coronary artery disease-related SCD (odds ratio, 1.44 [95% CI, 1.24-1.67

232 Incidence of coronary artery disease-related SCD decreased from 2001-2003 to 2013-201

233 n the young and specifically coronary artery disease-related SCD has declined in recent years.

234 ne-learning approaches, we aimed to decipher disease-related signature genes to find suitable sets of

235 ese results show that iVECs and iSMCs retain disease-related signatures, allowing modeling of vascula

236 R ligand selectivity and specific effects of disease-related single nucleotide variants.

237 e of lesion cap integrity and diminishes the disease-related SMC-to-chondromyocyte transition in athe

238 immediately intuitive results: for instance, disease-related SNVs create stronger changes in localize

239 There was no cumulative difference in disease-related spending between surgical groups by 5 ye

240 Overall, EVR patients incurred more disease-related spending in follow-up ($7355 EVR versus

241 Disease-related spending included the index operation an

242 We observed no cumulative difference in disease-related spending on EVR and open repair patients

243 he primary outcome was Medicare's cumulative disease-related spending, adjusted to 2015 dollars.

244 ight on a novel therapeutic avenue to target disease-related STKR1 mutants.

245 ate and, conversely, its inactivation during disease-related stress results in a spontaneous transiti

246 ith the advent of genetic testing in adults, disease-related, structural brain changes can be investi

247 We also show that the N-terminal disease-related surface contributes to the elevation of

248 f PI3,5P2: its catalytic site, an N-terminal disease-related surface, and a C-terminal region.

249 dical and drug history, and previous Crohn's disease-related surgeries were recorded at baseline.

250 associated with significant improvements in disease-related symptoms as measured by BFI, MDASI, and

251 Disease-related symptoms impair the quality of life of p

252 e not significantly different; however, some disease-related symptoms improved in patients receiving

253 we postulated that ruxolitinib would improve disease-related symptoms in patients with CLL.

254 thrombocythemia (ET) address thrombocytosis, disease-related symptoms, as well as risks of thrombosis

255 also seen for four of five FKSI-19 domains (disease-related symptoms, physical disease-related sympt

256 ponse rate, duration of response, effects on disease-related symptoms, safety, and tolerability.

257 domains (disease-related symptoms, physical disease-related symptoms, treatment side-effects, and fu

258 ze that this may be explained by respiratory disease-related systems instability and loss of adaptabi

259 Disease-related tau mutations increase the formation of

260 emia (AML) is poor and identification of new disease-related therapeutic targets remains a major goal

261 entiation, and the comparison of healthy and disease-related tissues at single-cell resolution.

262 nd methods, we also quantified the burden of disease related to high body-mass index (BMI), according

263 e of high-grade cervical, vulvar and vaginal disease related to HPV 31, 33, 45, 52, and 58 was 0.5 ca

264 , 52, and 58) vaccine against infections and disease related to HPV 31, 33, 45, 52, and 58, and non-i

265 PAH is the first human disease related to potential TET2 germline mutations.

266 e will then consider some paradigms of human disease related to protein degradation using selected ex

267 diatric patients with chronic ocular surface disease related to SJS/TEN and results in significant im

268 Grade II to IV acute graft-versus-host disease related to steroid treatment shows a trend towar

269 as early diagnosis of different neurological diseases related to abnormal levels of dopamine.

270 ns, mutations in DNAAF genes lead to several diseases related to cilia defects such as primary ciliar

271 ted predisposition to early onset autoimmune diseases related to cytokine hypersensitivity of immune

272 general hypothesis that aging and cancer are diseases related to energy metabolism.

273 d to gut microbiota", and "neurodegenerative diseases related to gut microbiota".

274 d mutations in sickle cell and other genetic diseases related to hemoglobin, while in Oxford, the gro

275 pe 2 diabetes, Alzheimer's disease, or other diseases related to IAPP dysfunction or cross-amyloid in

276 Diseases related to impaired blood flow such as peripher

277 ese genes were over-enriched in pathways and diseases related to inflammatory response and inhibition

278 ys of modulating uniporter activity to treat diseases related to mitochondrial Ca(2+) overload.

279 on is an attractive therapeutic paradigm for diseases related to NF-kappaB mis-regulation, but a diff

280 the disease, which is a model for ribosomal diseases, related to a heterozygous allelic variation in

281 mpetitive performance and reveals meaningful disease-related topics.

282 naffected relatives, suggesting that it is a disease-related trait.

283 Variances explained by adult-based GRSs for disease-related traits in adolescents, although still re

284 t a broad scope of phenotyping endpoints and disease-related traits in naive mice and those exposed t

285 ene studies with other cerebral small vessel disease-related traits strengthens the credibility of ap

286 For most disease-related traits the magnitude of the contribution

287 ould become associated at P < 5 x 10- 8 with disease-related traits through IEB alone, if disease pre

288 variants associated with human diseases and disease-related traits.

289 release (HR) was tested for time-of-day- or disease-related variability by conventional statistics a

290 formation by both wild-type TTR and a common disease-related variant, V30M TTR, as effectively as doe

291 er changes in localized frustration than non-disease related variants, and rare SNVs tend to disrupt

292 decade have identified tens of thousands of disease related variants, which in total explained only

293 candidate genes regulated by coronary artery disease-related variants and think that it will be an in

294 o reveal the capability of GenEpi in finding disease-related variants and variant interactions that s

295 ughput genomic approach enabled detection of disease-related variants in unexpected genes; permitted

296 r AF and electrocardiographic traits to link disease-related variants to genes.

297 tep for identifying known genetic traits and disease-related variants within an individual.

298 m and associated functional perturbations in disease-related variants, knowledge of high-resolution s

299 Alcoholic liver disease-related WL registrations and liver transplantati

300 e of false-positive claims that a variant is disease related) yielded rates of 24.2% in cases and 5.5