ライフサイエンスコーパス: dishevelled

1 ssociated with the PCP proteins Frizzled and Dishevelled.

2 ovide evidence that Seahorse associates with Dishevelled.

3 n a process that requires the recruitment of Dishevelled.

4 downstream of heterotrimeric G proteins and Dishevelled.

5 plex between the two DIX domains of Axin and Dishevelled.

6 regulation of cell polarity by Frizzled and Dishevelled.

7 eta-catenin, possibly via targets other than Dishevelled.

8 regulates canonical Wnt signaling by binding Dishevelled.

9 FZD2 to interact with its downstream target DISHEVELLED.

10 he DIX domain of the Wnt signalling molecule dishevelled.

11 endent recruitment of signaling effectors by Dishevelled.

12 signaling, probably due to interaction with dishevelled.

13 2 reporter was mediated by the DEP domain of Dishevelled.

14 cochleae lacked the polarized PCP components dishevelled 1/2 and frizzled 3/6, while other PCP protei

15 n signalling associated with hyper-activated Dishevelled-1 (Dvl-1) localized to the basal body.

16 We show that loss of function of Dishevelled-1 (Dvl1) mimics and enhances the Wnt7a pheno

17 teraction of release machinery proteins with Dishevelled-1 (Dvl1), a scaffold protein that determines

18 Here, we report unexpected roles of Dishevelled 2 (Dvl2) and interphase polo-like kinase 1 (

19 Here, we show that Dishevelled 2 (Dvl2), a key component of the Wnt signali

20 estingly, as embryos reach blastocyst stage, Dishevelled 2 becomes increasingly associated with cell

21 and thus indirectly attenuates inhibition of Dishevelled 2 in the Wnt/beta-catenin pathway.

22 In these cells, the core PCP molecule Dishevelled 2, the BB/spindle positioning protein Dlg3,

23 is not required for membrane recruitment of Dishevelled 2; Ptk7 and Frizzled3/Frizzled6 receptors ac

24 Knockdown of Dishevelled-2 (Dvl-2) and Dvl-3 also suppressed neurite

25 a-arrestin recruitment and activation of the dishevelled-2 (Dvl-2) scaffold and not by G protein alph

26 components of the Wnt pathway, specifically Dishevelled-2 (Dvl2) expression, resulting in diminished

27 Coil Kinase 1 (ROCK1) activity downstream of Dishevelled-2 (Dvl2).

28 romotes Frizzled1 endocytosis, downregulates Dishevelled-2 protein, and inhibits Wnt3A-stimulated bet

29 iscuity in five PDZ domains: the human Dvl2 (Dishevelled-2) PDZ domain, the human Erbin PDZ domain, t

30 through the canonical Wnt pathway involving dishevelled-2, beta-catenin and survivin.

31 Previously we determined that Dishevelled-2/3 (Dvl) mediate Wnt-3a-dependent neurite o

32 PDZRN3 ubiquitinates Dishevelled 3 (Dvl3), to promote endocytosis of the Friz

33 brane in trophectoderm cells, while at E4.5, Dishevelled 3 is highly enriched in the cytoplasm of ICM

34 ile other PCP proteins (Vangl1/2, Celsr1 and dishevelled 3) remained localized.

35 Dishevelled-3 (Dvl3), a key component of the Wnt signali

36 on assays and induces the phosphorylation of Dishevelled, a cytoplasmic component downstream of Frizz

37 Dishevelled, a phosphoprotein scaffold, is a central com

38 signaling proteins Frizzled, Strabismus, and Dishevelled act in concert with the small GTPase Rac1 to

39 (dsh1), we show that this mutation inhibits Dishevelled activation of Rac, regardless of its subcell

40 Dishevelled also has important roles in the governance o

41 vertebrate homologue of Lgl associates with Dishevelled, an essential mediator of Wnt signalling, an

42 has been identified by its association with Dishevelled, an intracellular component of Wnt signal tr

43 to the E3 ligase, and test models suggesting Dishevelled and APC2 compete for association with Axin.

44 We demonstrate that DVL dishevelled and axin (DIX) domain, but not DIX domain-me

45 ndings indicate that the interaction between Dishevelled and Axin through their DIX domains is crucia

46 antibody is confirmed by down-regulation of Dishevelled and beta-catenin.

47 ing activity is dependent on the presence of Dishevelled and blocked in the absence of Dynamin and Ra

48 WGEF protein can bind to Dishevelled and Daam-1, and deletion of the Dishevelled-

49 HisC aggregation is facilitated by Dishevelled and depends on accumulation of Naked/NKD dur

50 rotein Frizzled and the cytoplasmic proteins Dishevelled and Diego localize to distal cell ends, the

51 gnaling in endothelial cells, as measured by Dishevelled and ERK1/2 phosphorylation, and inhibition o

52 Finally, accumulation of Dishevelled and Inturned near the basal apparatus of cil

53 tionship between subcellular localization of Dishevelled and its signaling activities remains unclear

54 e show that maternal JNK activation requires Dishevelled and JNK is enriched in the nucleus of Xenopu

55 embrane by Frizzled 3, formed a complex with Dishevelled and phosphorylated Dsh in vitro.

56 CP interactions, including interactions with Dishevelled and Prickle that function in a context-depen

57 Dishevelled and RhoA act downstream of Wnt11-Ror2 to reg

58 f beta-catenin-independent signaling through Dishevelled and Ror2 causes predictable changes in premi

59 he Wnt pathway components Silberblick/Wnt11, Dishevelled and Strabismus.

60 y protein Daam1 as an important link between Dishevelled and the Rho GTPase for cytoskeletal modulati

61 larized distribution of the core PCP protein Dishevelled and to position the primary cilium at the ab

62 ne, and Frizzled-7 induced colocalization of Dishevelled and WGEF.

63 or Wnt5a activation of p38; siRNAs targeting Dishevelleds and expression of the Dishevelled antagonis

64 ream signaling molecules (i.e., Frizzled and Dishevelled) and moreover may provide a valuable means o

65 ventricles, PCP regulators (e.g., Vangl2 and Dishevelled), and cytoskeletal networks in the establish

66 receptor-related proteins 5 and 6 (LRP5/6), Dishevelled, and Axin signalosome assembly and provide a

67 thways share the effector proteins frizzled, dishevelled, and beta-arrestin.

68 ecruited to the posterior cortex by Frizzled/Dishevelled, and in turn polarizes the apical-basal pola

69 PSD-95, Syntenin, Erbin, GRIP, NHERF, Inad, Dishevelled, and Shank).

70 nsity lipoprotein receptor-related protein), dishevelled, and the glycogen synthase kinase shaggy (GS

71 targeting Dishevelleds and expression of the Dishevelled antagonist Dapper-1 do not suppress the p38

72 PAR-1 phosphorylation sites in Dishevelled are required for this translocation, but not

73 Dishevelleds are modular proteins that lie at the crossr

74 Thus, we identify a dual function for Dishevelled as an inhibitor of Notch signalling and an a

75 CXXC-type zinc finger protein 5 (CXXC5) with Dishevelled as one such negative regulator of WNT in hai

76 e have renamed WID (WT1-induced Inhibitor of Dishevelled), as a novel WT1 transcriptional target that

77 s with functional reporter assays identified dishevelled associated activator of morphogenesis 1 (DAA

78 eracting with its downstream effector Daam1 (Dishevelled associated activator of morphogenesis 1), an

79 Dishevelled-associated activator of morphogenesis 1 (Daa

80 a constitutively active C-terminal domain of Dishevelled-associated activator of morphogenesis 1 (DAA

81 Daam1 (dishevelled-associated activator of morphogenesis-1) is

82 upon Wnt3a stimulation by beta-arrestin- and Dishevelled-associated kinases.

83 hown very recently to bridge Wnt-induced and Dishevelled-associated PtdIns(4,5)P2 production to the p

84 Dishevelled-Associating Protein with a high frequency of

85 We show that Dishevelled-associating protein with a high frequency of

86 Levels of Dishevelled at junctions are regulated by a Cullin-3-Dia

87 Rpgrip1l was also essential for stabilizing dishevelled at the cilium base in the zebrafish floor pl

88 d:Dishevelled interactions at the expense of Dishevelled: Axin interactions when Dishevelled levels a

89 fied CamKII as an interaction partner of the dishevelled-beta-arrestin protein complex by quantitativ

90 ifferent Dvl proteins and the composition of dishevelled-beta-arrestin protein complexes contribute t

91 We hypothesized that the composition of dishevelled-beta-arrestin protein complexes contributes

92 lled via its C-terminal CXXC zinc finger and Dishevelled binding domains and potently inhibits WNT/be

93 nous-related formin first studied as a novel dishevelled binding protein and shown to be crucial for

94 Dishevelled and Daam-1, and deletion of the Dishevelled-binding domain generates a hyperactive from

95 trigger non-canonical Wnt signaling via the Dishevelled-binding protein, Daple.

96 Mechanistically, Dishevelled binds and directly inhibits CSL transcriptio

97 onal analyses demonstrate that regulation of Dishevelled by this ubiquitin ligase antagonizes the Wnt

98 oth membrane-targeted and cytoplasm-targeted Dishevelled can potently activate canonical Wnt signalin

99 , an intracellular phosphoprotein that binds Dishevelled, catenins, and other signaling proteins, is

100 , RNA interference (RNAi) of beta-catenin or dishevelled causes the inappropriate regeneration of a h

101 IX domain of Dishevelled provided that these Dishevelled chimeras retained a DIX head or tail surface

102 s for apical-basal polarity and the Frizzled/Dishevelled complex for PCP), a diverse array of polariz

103 P signaling through Knypek (Glypican4/6) and Dishevelled components.

104 n and focus on the biological processes that Dishevelled controls.

105 me, and, in this complex, Rpgrip1l prevented dishevelled degradation.

106 enin stability, our data on the stability of Dishevelled demonstrates that two distinct ubiquitin lig

107 n, as does suppression of the phosphoprotein Dishevelled, demonstrating that casein kinase 2 is downs

108 icted junctional domains containing Frizzled/Dishevelled/Diego (Fz/Dsh/Dgo) or Van Gogh/Prickle (Vang

109 ossibility that this may result by promoting Dishevelled:Dishevelled interactions at the expense of D

110 n-canonical Wnt signaling is blocked using a Dishevelled dominant-negative protein, gastrulation move

111 Frizzed-7 Wnt receptor and the PDZ domain of Dishevelled, down-regulating canonical Wnt signaling and

112 Both pathways require members of the Dishevelled (Dsh or Dvl) family of cytoplasmic factors f

113 We identified peptide aptamers against Dishevelled (Dsh) and beta-catenin (beta-cat) to target

114 Armadillo (Arm)/beta-catenin and Dishevelled (Dsh) are key components of Wnt signal trans

115 calization of LIN-17/Frizzled (Fz) and MIG-5/Dishevelled (Dsh) during the B cell division.

116 itive to dgo dosage or dominantly modified a dishevelled (dsh) GOF phenotype, supporting a role in Fz

117 Dishevelled (Dsh) is a key signaling molecule in the can

118 strate that dAbl positively regulates the Fz/Dishevelled (Dsh) PCP pathway without affecting canonica

119 We demonstrate that Dishevelled (Dsh) plays an important role in mediating t

120 ll movement through its association with the Dishevelled (Dsh) protein.

121 Dishevelled (Dsh) proteins DSH-1 and MIG-5 redundantly m

122 olarity (PCP) gene products prickle (pk) and dishevelled (dsh) show M/L polarization.

123 of APC/C function leads to reduced levels of Dishevelled (Dsh), a core PCP factor.

124 ivisions proceed normally in embryos lacking dishevelled (dsh), a key component of the PCP pathway.

125 rbs CE and disrupts membrane localization of Dishevelled (Dsh), a key regulator of PCP and CE.

126 choline receptors with weak interaction, (b) dishevelled (Dsh), and (c) another four proteins, Rapsyn

127 We found that knockdown of fz, dishevelled (dsh), Axin, and gilgamesh (gish) also reduc

128 the Wnt receptor-associated scaffold protein Dishevelled (Dsh), but the mechanism by which Nkd inhibi

129 n bind and inhibit the Wnt signal transducer Dishevelled (Dsh), but the mechanism by which Nkd limits

130 s involved in PCP, such as Frizzled (Fz) and Dishevelled (Dsh), but there is also some evidence that

131 protein receptor-related protein [LRP] 5/6), dishevelled (dsh), casein kinase Igamma, G proteins, and

132 With the exception of dishevelled (dsh), the genes functioning in these two pa

133 luding frizzled (fz), flamingo/starry night, dishevelled (dsh), Van Gogh/strabismus and prickle, func

134 CP) pathway, together with Frizzled (Fz) and Dishevelled (Dsh).

135 ugh an interaction with the scaffold protein Dishevelled (Dsh).

136 gnaling by binding the intracellular protein Dishevelled (Dsh).

137 tself interacts with the Wnt pathway protein Dishevelled (Dsh).

138 Removal of two dishevelleds (dsh-2 and mig-5) leads to a global loss of

139 and a 'PCP-core' including Frizzled(Fz) and Dishevelled(Dsh) contribute to polarization of individua

140 However, FBM neurons migrated normally in Dishevelled (Dvl) 1/2 double mutants, and in zebrafish e

141 e Lys63-linked polyubiquitin chains modulate Dishevelled (Dvl) activity upstream in the Wnt/beta-cate

142 rodent embryo fibroblasts, we show here that dishevelled (Dvl) and axin, two major components of the

143 ceptor complex leading to the recruitment of Dishevelled (Dvl) and Axin1 to the plasma membrane.

144 ty (PCP) pathway, through the recruitment of Dishevelled (Dvl) and Dvl-associated activator of morpho

145 This effect is mimicked by the expression of Dishevelled (Dvl) and is blocked by Sfrp1, a secreted Wn

146 2) Par1b attenuates the effect of Dishevelled (Dvl) expression, an inducer of wnt signalin

147 rane recruitment of the cytoplasmic effector Dishevelled (Dvl) is a critical step in Wnt/beta-catenin

148 Dishevelled (Dvl) is a key component of Wnt/beta-catenin

149 Dishevelled (Dvl) is a key molecule downstream of Fz rec

150 Dishevelled (DVL) is a key scaffolding protein and a bra

151 Dishevelled (Dvl) is a scaffold protein that serves as t

152 Dishevelled (Dvl) is an essential protein in the Wnt sig

153 Dishevelled (DVL) is associated with axonal microtubules

154 ociliary epithelial development to show that Dishevelled (Dvl) is essential for the apical positionin

155 Dishevelled (DVL) is the key component of the Wnt signal

156 The intracellular signaling molecule Dishevelled (Dvl) mediates canonical and non-canonical W

157 trulation, the non-canonical Wnt pathway via Dishevelled (Dvl) orchestrates the activities of the GTP

158 Recently, we reported Wnt signaling and dishevelled (Dvl) overexpression in malignant pleural me

159 SIRT1 regulates Dishevelled (DVL) protein levels in cancer cells, and DV

160 Dishevelled (Dvl) protein plays a central role in this p

161 accumulation of PCP core components, such as Dishevelled (Dvl) protein, is associated with PCP functi

162 elated protein 6 (Lrp6), and the cytoplasmic dishevelled (Dvl) protein.

163 Dishevelled (DVL) proteins are central mediators of the

164 Because Dishevelled (Dvl) proteins are effectors of both canonic

165 Dishevelled (Dvl) proteins are intracellular effectors o

166 Dishevelled (DVL) proteins serve as crucial regulators t

167 nificant decrease in the levels of all three Dishevelled (Dvl) proteins.

168 Dishevelled (Dvl) transduces Wnt signals from the recept

169 sing the Xenopus laevis embryo, we show that Dishevelled (Dvl), a key Wnt signaling scaffold that is

170 Here we uncover an unexpected role of Dishevelled (DVL), a positive Wnt regulator, in promotin

171 tumor cell lines was mediated by Frizzled3, Dishevelled (Dvl), and c-Jun N-terminal kinase.

172 sembly by controlling the phosphorylation of Dishevelled (DVL), another ciliogenesis regulator.

173 recruitment of shared components, including dishevelled (Dvl), axin, and glycogen synthase kinase 3

174 coreceptors activates the cytosolic effector Dishevelled (Dvl), leading to the recruitment of Axin an

175 PCP proteins, including Van Gogh (Vang) and Dishevelled (Dvl), segregate into distinct complexes on

176 tream regulator of this signaling pathway is Dishevelled (Dvl), which, among other multiple interacti

177 matin array data, we identified the protein, dishevelled (DVL)-2, as being regulated in the nucleus a

178 a complex partly by limiting the activity of dishevelled (DVL).

179 tenin signaling requires the adapter protein Dishevelled (Dvl).

180 on of convergent extension (CE) movements is Dishevelled (Dvl).

181 o binding but rather by its interaction with Dishevelled (Dvl).

182 trin (DEP) domain of the Wnt pathway protein Dishevelled (Dvl).

183 by WNTs and regulated by the phosphoprotein Dishevelled (DVL).

184 s the cytoplasmic effectors Prickle (Pk) and Dishevelled (Dvl).

185 Dishevelled (Dvl/Dsh) protein is one of key components i

186 lity of the crucial Wnt signalling effector, dishevelled (Dvl2), and impairing Wnt signalling.

187 ate the K63-linked polyubiquitination of the Dishevelled, Egl-10 and Pleckstrin (DEP) domain of the W

188 bitory function of DSH-1, which requires its dishevelled, Egl-10, and pleckstrin (DEP) domain, acts b

189 Among these, the first dishevelled, Egl-10, and pleckstrin domain (DEP1) remain

190 This translocation requires the Dishevelled, Egl-10, Pleckstrin (DEP) domain, but the mo

191 the interface between Gbeta5 and N-terminal Dishevelled, EGL-10, Pleckstrin/DEP Helical Extension (D

192 es significant conformational changes in the dishevelled/Egl/pleckstrin (DEP) domain, a conserved str

193 DME cells of embryos mutant for wingless or dishevelled exhibit polarisation defects and fail to clo

194 We identify mig-5, a Dishevelled family member, as a gene that regulates seve

195 We report the interaction of LRRK2 with the dishevelled family of phosphoproteins (DVL1-3), key regu

196 ed receptors and cytoplasmic proteins of the Dishevelled family; however, there has been some dispute

197 The C3 VCD competes with Dishevelled for binding to the DIX domain of Axin1, whic

198 s block the dissociation of the Wnt effector Dishevelled from nucleoredoxin.

199 Removal of Dishevelled from the cell membrane disrupts convergent e

200 n to be an important switch in regulation of Dishevelled function and Wnt signaling.

201 P pathway, but, importantly, may not require Dishevelled function.

202 Dishevelled genes (Dvls) are essential for Wnt signaling

203 When Dishevelled-GFP fusion proteins are overexpressed in sin

204 enin pathway in CML CD34+ cells by depleting dishevelled homolog 3 (DVL3).

205 Here, we describe a role for a C. elegans Dishevelled homolog, DSH-2, in an asymmetric neuroblast

206 ng mice with null mutations in two mammalian Dishevelled homologs, Dvl1 and Dvl2, that during neurula

207 sttranslationally and relies on frizzled and dishevelled homologs, which also control POP-1 asymmetry

208 a switch, promoting Strabismus mobility and Dishevelled immobility, thus enhancing sorting of these

209 E3 ubiquitin ligase complex is recruited to Dishevelled in a Wnt-dependent manner that promotes its

210 nt to account for the pathway specificity of Dishevelled in the canonical Wnt versus PCP signaling ca

211 we have identified proteins associated with Dishevelled, including a Cullin-3 ubiquitin ligase compl

212 hese novel results are the first to detail a Dishevelled-independent Wnt response, demonstrating a cr

213 fic for the Wnt receptor signaling component Dishevelled induced lysosomal fusion with ehrlichial inc

214 d in the presence of Wnt whereas the tuberin-Dishevelled interaction was increased.

215 some dispute regarding whether the Frizzled-Dishevelled interactions are the same in both cases.

216 plying that qualitatively different Frizzled-Dishevelled interactions underlie canonical signaling.

217 e view that qualitatively different Frizzled-Dishevelled interactions underlie planar polarity and ca

218 Dishevelled is a conserved protein that interprets signa

219 ta demonstrate that membrane localization of Dishevelled is a prerequisite for vertebrate PCP signali

220 Dishevelled is an important transducer of divergent Wnt

221 localizes at the anterior cell edge, whereas Dishevelled is enriched posteriorly.

222 lasmic region of RNF43 and the PDZ domain of dishevelled is essential for this suppression.

223 Dishevelled is not required for Wnt5a activation of p38;

224 In the present study, we report that Dishevelled is post-translationally modified, both in vi

225 Dvl (Dishevelled) is one of several essential nonenzymatic co

226 lin-44 and egl-20, lin-17/Frizzled and dsh-1/Dishevelled, is compromised, synapses develop ectopicall

227 pense of Dishevelled: Axin interactions when Dishevelled levels are high.

228 We find that elevating Dishevelled levels in Drosophila embryos has paradoxical

229 When we elevate Dishevelled levels, it forms its own cytoplasmic puncta,

230 ciliopathy protein complex that finely tunes dishevelled levels, thereby modulating planar cell polar

231 The DEP domain of dishevelleds mediates planar polarity of cells within a

232 erases 1 and 7 as the key enzymes catalyzing Dishevelled methylation.

233 F9 teratocarcinoma cells results in reduced Dishevelled methylation.

234 , and is required for local concentration of Dishevelled (MIG-5) in the ABar cortex adjacent to C.

235 The DIX domain of dishevelleds modulates a beta-catenin destruction comple

236 xpression of a dominant negative Wnt11 and a Dishevelled mutant Xdd1.

237 Corresponding Xenopus Dishevelled mutants show compromised ability to interfer

238 ates with greater colocalized Wg, Arrow, and Dishevelled on endosomes.

239 does not alter the total cellular levels of Dishevelled or Flamingo, but only that of the junctional

240 onents of the canonical Wnt pathway, such as dishevelled or Tcf, also results in ventrally curved sal

241 ified aberrant Wnt activation as a result of Dishevelled overexpression in malignant mesothelioma.

242 t5a-dependent processes in vivo and identify Dishevelled phosphorylation as a physiological target of

243 suggesting that differential methylation of Dishevelled plays an important role in Wnt signaling.

244 Through its many signaling activities, Dishevelled plays important roles in the embryo and the

245 catenin complexes (AGbetaC) as Wnt decreases Dishevelled/PLIN2 but increases AGbetaC/PLIN2 associatio

246 dimerization provides cross-linking between Dishevelled polymers, illustrating a key principle under

247 er within Axin, to destabilize it along with Dishevelled, possibly via the autophagy receptor p62, wh

248 In contrast the cytoplasmic components Dishevelled, Prickle and Diego are not needed for interc

249 is promoted by the core proteins Strabismus, Dishevelled, Prickle, and Diego.

250 veloping new reagents to sequester wild-type Dishevelled protein either at the cell membrane or away

251 The Dishevelled protein mediates several diverse biological

252 The Dishevelled protein regulates many developmental process

253 inhibits cell movements and localization of Dishevelled protein to the cell cortex, processes associ

254 ling, suggesting that local concentration of Dishevelled protein, but not its spatial localization, i

255 Here we show that three of the mouse Dishevelled proteins are not only expressed in oocytes a

256 of the beta-catenin destruction complex and dishevelled proteins in vivo and is recruited to membran

257 LIN-17 and DSH-1/Dishevelled proteins were recruited to the pruning neuri

258 act differentially with the three vertebrate dishevelled proteins.

259 nctionally substituted for the DIX domain of Dishevelled provided that these Dishevelled chimeras ret

260 milarly, the methylation-deficient mutant of Dishevelled, R271K, displayed spontaneous membrane local

261 ellular localization of the core PCP protein Dishevelled, recruiting it to Rab8-positive vesicles and

262 regions of the Frizzled receptor that block Dishevelled recruitment.

263 sential mediator of Wnt signalling, and that Dishevelled regulates the localization of Lgl in Xenopus

264 Dishevelled relays Wnt signals from the plasma membrane

265 polymerization of the DIX domains of Axin or Dishevelled, respectively, which increases their avidity

266 eads to the activation of a noncanonical Wnt/dishevelled signal transduction pathway that cooperates

267 These findings suggest that Wnt5a-Ror-Dishevelled signaling constitutes a core noncanonical Wn

268 Finally, we show that blocking noncanonical dishevelled signaling in muscle fibers disrupts AChR pre

269 he downstream effector beta-catenin, and the Dishevelled signalosome, which inactivates the Axin comp

270 ell killing induced by either Wnt-1 siRNA or Dishevelled siRNA in these cells.

271 Both Wnt-1 small interfering RNA (siRNA) and Dishevelled siRNA induced significant apoptosis in these

272 Rpgrip1l in planar polarity was mediated by dishevelled stabilization.

273 Studies looking at mutated forms of Dishevelled suggested that stable recruitment of Disheve

274 eraction between FZDs and the phosphoprotein Dishevelled, supporting conformational selection as a pr

275 phates [PtdIns (4,5)P2] through frizzled and dishevelled, the latter of which directly interacted wit

276 Axin also binds to Dishevelled through its DIX domain.

277 with Dkk2C unmasked its ability to signal to Dishevelled through multiple frizzleds, indicating that

278 that the key modular intracellular mediator Dishevelled, through a specific activation of RhoA GTPas

279 Here, we show that Wnt acts via Dishevelled to inhibit Notch signalling, and that this c

280 evelled suggested that stable recruitment of Dishevelled to membranes by Frizzled was required only f

281 mponent of the Wnt-PCP pathway that connects Dishevelled to Rho activation.

282 At the molecular level, Gpr125 recruited Dishevelled to the cell membrane, a prerequisite for Wnt

283 Wnt5b stimulation, Fz2 but not Ryk recruits Dishevelled to the cell membrane, suggesting that Fz2 an

284 Asymmetrical localization of Prickle and Dishevelled to the opposite cell edges in zebrafish gast

285 n-4, two ciliopathy proteins known to target dishevelled to the proteasome, and, in this complex, Rpg

286 Wnt signals act though Dishevelled to turn down the destruction complex, stabil

287 the Wnt/Frizzled pathway seems to occur from Dishevelleds to axin/glycogen synthase kinase 3(GSK3)/be

288 and in parallel to lin-17/frizzled and dsh-1/dishevelled, to determine the direction of neurite growt

289 g Frizzled, Van Gogh, Flamingo, Prickle, and Dishevelled, to establish their characteristic asymmetri

290 based assays, to show that the DEP domain of Dishevelled undergoes a conformational switch, from mono

291 nalysis demonstrated that WID interacts with Dishevelled via its C-terminal CXXC zinc finger and Dish

292 s the Wnt signalosome, which is assembled by Dishevelled via reversible head-to-tail polymerization b

293 Additionally, loss of phosphorylation of Dishevelled - which normally localises to opposite cell

294 , an ancient signaling pathway transduced by Dishevelled, which assembles signalosomes by dynamic hea

295 Naked/NKD destabilizes Dishevelled, which assembles Wnt signalosomes to inhibit

296 discovered an unexpected antagonism between Dishevelleds, which may function as a signal amplificati

297 ic aspects of CE that involve interaction of Dishevelled with mediators different from that of RhoA G

298 idue sequence motifs first recognized in fly Dishevelled, worm EGL-10, and mammalian Pleckstrin), we

299 ingly, within the same tissues where Xenopus Dishevelled (Xdsh) controls cell fate via canonical Wnt

300 ulation was disrupted by the manipulation of Dishevelled (Xdsh) signaling.