ライフサイエンスコーパス: disintegrin

1 the conformational design of antimetastatic disintegrins.

2 Increased expression of metalloprotease-disintegrin ADAM12 is a hallmark of several pathological

3 Metalloprotease-disintegrin ADAM12 is overexpressed and frequently mutat

4 a causes upregulation of the metalloprotease-disintegrin ADAM8 (A8) in affected brain regions, spinal

5 sess the contribution of the metalloprotease-disintegrin ADAM9 to ocular neovascularization in mice.

6 Ectodomain cleavage by A-disintegrin and -metalloproteases (ADAMs) releases many

7 This identified ADAM6, a member of the A disintegrin and A metalloprotease (ADAM) family; members

8 talloproteinase with thrombospondin motif, a disintegrin and a metalloprotease, interleukin (IL)-1bet

9 This study investigates the role of a disintegrin and a metalloproteinase (ADAM) 10 and ADAM17

10 A disintegrin and a metalloproteinase domain (ADAM) 9 is k

11 Since PrP(C) is cleaved by members of the disintegrin and matrix-metalloprotease family that are i

12 d generation of the soluble IL-6R by ADAM (a disintegrin and metallo) proteases enables IL-6 trans-si

13 creted proteases, ovochymase 2 (OVCH2) and A disintegrin and metallopeptidase 28 (ADAM28), were expre

14 We found that recombinant a disintegrin and metalloprotease (ADAM) 17 cleaved the ec

15 alpha(5)beta1 binds a disintegrin and metalloprotease (ADAM) 17, a metalloenzy

16 dding of HEPCAM at two alpha-sites through a disintegrin and metalloprotease (ADAM) and at one beta-s

17 Catalytically active members of the A Disintegrin And Metalloprotease (ADAM) family of membran

18 metalloproteases, especially those of the A disintegrin and metalloprotease (ADAM) family, can media

19 from the cell surface by proteases in the A Disintegrin And Metalloprotease (ADAM) family.

20 embrane-bound precursors by one of several a disintegrin and metalloprotease (ADAM) metalloproteases,

21 A disintegrin and metalloprotease (ADAM) proteases are imp

22 Using a disintegrin and metalloprotease (ADAM)-17 radiation chim

23 ion of matrix metalloproteinase (MMP)- and a disintegrin and metalloprotease (ADAM)-family zinc metal

24 e evidence that human Tim-3 is a target of A disintegrin and metalloprotease (ADAM)-mediated ectodoma

25 The cytoplasmic domain of a disintegrin and metalloprotease (ADAM)10, a transmembran

26 with a TLR3 or TLR4 ligand, we identified a disintegrin and metalloprotease (ADAM)15 as a novel TRIF

27 As a disintegrin and metalloprotease (ADAM)s have been implic

28 endogenous AXL was dependent on the sheddase disintegrin and metalloprotease 10 (ADAM10) and the gamm

29 It is reported here that a disintegrin and metalloprotease 10 (ADAM10) interacts wi

30 A disintegrin and metalloprotease 10 (ADAM10) is a transme

31 A disintegrin and metalloprotease 10 (ADAM10) is a ubiquit

32 A disintegrin and metalloprotease 10 (ADAM10) is a ubiquit

33 The membrane-anchored metalloproteinase a disintegrin and metalloprotease 10 (ADAM10) is required

34 he alpha-hemolysin binding to its receptor A-disintegrin and metalloprotease 10 (ADAM10) upregulates

35 by an initial shedding event catalyzed by A Disintegrin and Metalloprotease 10 (ADAM10).

36 n of the cellular receptor of alpha-toxin, a disintegrin and metalloprotease 10 (ADAM10).

37 esis or inhibition of mCD23 cleavage by an a disintegrin and metalloprotease 10 inhibitor, GI254023X,

38 (m)CD23 by the endogenous metalloprotease a disintegrin and metalloprotease 10.

39 cytoskeleton morphology and recruitment of a disintegrin and metalloprotease 10.

40 on its shedding and binding activities, the disintegrin and metalloprotease 12 (ADAM12) has been imp

41 was significantly correlated with ADAM12 (A Disintegrin And Metalloprotease 12) expression in these

42 ng enzyme type 2 (ACE2) and an increase in a disintegrin and metalloprotease 17 (ADAM17) activity in

43 Amino acid polymorphisms within a disintegrin and metalloprotease 17 (Adam17) can account,

44 A disintegrin and metalloprotease 17 (ADAM17) is a major s

45 We have directly shown that A disintegrin and metalloprotease 17 (ADAM17) is a primary

46 HER2 trans-activation by IL-1beta required a disintegrin and metalloprotease 17 (ADAM17)-dependent sh

47 (iRhom2) is required for the maturation of A disintegrin and metalloprotease 17 (ADAM17, also called

48 Lastly, a disintegrin and metalloprotease 17 (ADAM17; also known a

49 The metalloproteinase ADAM17 (a disintegrin and metalloprotease 17) controls EGF recepto

50 ADAM17 (a disintegrin and metalloprotease 17) controls pro- and an

51 The metalloprotease ADAM17 (a disintegrin and metalloprotease 17) is a key regulator o

52 ADAM17 (a disintegrin and metalloprotease 17) is believed to be a

53 The metalloprotease ADAM17 (a disintegrin and metalloprotease 17) regulates EGF-recept

54 Protein ectodomain shedding by ADAM17 (a disintegrin and metalloprotease 17), a principal regulat

55 vascular epithelial growth factor (VEGF), a disintegrin and metalloprotease 33 (ADAM33), and periost

56 dding is largely attributed to a family of a disintegrin and metalloprotease domain (ADAM) metallopro

57 n of collagen I, CD45, and CD34 or EGFR or a disintegrin and metalloprotease domain 17 and placed in

58 with glutamate and GABA neurotransmission: a disintegrin and metalloprotease domain 22 (Adam22) and h

59 ivation of the sheddase molecule, ADAM 10 (A disintegrin and metalloprotease domain-containing protei

60 A disintegrin and metalloprotease domain-containing protei

61 nuclear factor of activated T-cells; ADAM, a disintegrin and metalloprotease domain; OTM, orthodontic

62 superfamily characterized by the presence of disintegrin and metalloprotease domains.

63 ADAM10, a member of a disintegrin and metalloprotease family, is an alpha-secr

64 , a member of the matrix metalloproteinase/a disintegrin and metalloprotease family.

65 ed from the cell surface by proteinases of a disintegrin and metalloprotease family; however, the mec

66 ecent studies suggest that serum levels of a disintegrin and metalloprotease protein-12 (ADAM-12) can

67 he length of VWF is regulated by ADAMTS13 (a disintegrin and metalloprotease with a thrombospondin ty

68 A disintegrin and metalloprotease with a thrombospondin ty

69 ADAMTSs (a disintegrin and metalloprotease with thrombospondin doma

70 rly active 29/31-kDa form of VEGF-C by the A disintegrin and metalloprotease with thrombospondin moti

71 These results identify A disintegrin and metalloprotease with thrombospondin moti

72 A disintegrin and metalloprotease with thrombospondin moti

73 tablished in a pilot approach, identifying a disintegrin and metalloprotease with thrombospondin moti

74 pericytes rapidly activated expression of a disintegrin and metalloprotease with thrombospondin moti

75 t out to investigate the role of ADAMTS-5 (a disintegrin and metalloprotease with thrombospondin moti

76 -21 encodes ADT-2, a member of the ADAMTS (a disintegrin and metalloprotease with thrombospondin moti

77 These proteins belong to the ADAMTS (a disintegrin and metalloprotease with thrombospondin repe

78 dothelial cell (HUVEC)-released ADAMTS-13 (a disintegrin and metalloprotease with thrombospondin repe

79 from the endothelial surface by ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type

80 (2) serum creatinine >2.25 mg/dL, and (3) a disintegrin and metalloprotease with thrombospondin type

81 a (TTP) by identifying naturally processed A Disintegrin And Metalloprotease with ThromboSpondin type

82 patients with diabetes, impaired ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type

83 unoglobulin G (IgG) autoantibodies against A Disintegrin And Metalloprotease with ThromboSpondin type

84 The protease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type

85 ulman syndrome [USS]) severe deficiency of a disintegrin and metalloprotease with thrombospondin type

86 cleavage of von Willebrand factor (VWF) by A disintegrin and metalloprotease with thrombospondin type

87 The metalloprotease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type

88 elated to a severe deficiency in ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type

89 in protein C, protein S, antithrombin and A Disintegrin and Metalloprotease with Thrombospondin type

90 encodes a metalloprotease similar to the "a disintegrin and metalloprotease with thrombospondin" (AD

91 induced shedding was abrogated by an ADAM (A disintegrin and metalloprotease) 10 and 17 selective inh

92 scular smooth muscles, KK stimulates ADAM (a disintegrin and metalloprotease) 17 activity via a PAR1/

93 latory region (NRR) that protects an ADAM (a disintegrin and metalloprotease) cleavage site.

94 disintegrin-like domain found in the ADAM (a disintegrin and metalloprotease) family of proteins.

95 re we show that receptor cleavage by ADAM (A Disintegrin And Metalloprotease) metalloproteases promot

96 ADAMDEC1 (Decysin-1) is a putative ADAM (a disintegrin and metalloprotease)-like metalloprotease wi

97 lytically cleaved from the cell surface by a disintegrin and metalloprotease, ADAM10.

98 A disintegrin and metalloprotease-17 (ADAM17) is a major s

99 A disintegrin and metalloprotease-17 (ADAM17) is shown to

100 ransmembrane cell-surface metalloprotease, a disintegrin and metalloprotease-17 (ADAM17), and into AD

101 tream matrix metalloproteinases (MMPs) and a disintegrin and metalloproteases (ADAMs) and stimulate p

102 ng mediated by the cell surface proteases "a disintegrin and metalloproteases" (ADAM)-10 and ADAM-17,

103 todomain shedding, which was not mediated by disintegrin and metalloproteases.

104 le of TSPAN33, a tetraspanin implicated in a disintegrin and metalloproteinase (ADAM) 10 maturation,

105 in-22alpha promotor-driven deficiency of the disintegrin and metalloproteinase (ADAM) 17 (SM22-Adam17

106 A Disintegrin And Metalloproteinase (ADAM) 17 is one of th

107 Peptidases of the a-disintegrin and metalloproteinase (ADAM) family are impl

108 med a PCR screen for proteolyticlly active A Disintegrin And Metalloproteinase (ADAM) family members.

109 Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidas

110 Serial processing of Cad6B by a disintegrin and metalloproteinase (ADAM) proteins and ga

111 Specific a disintegrin and metalloproteinase (ADAM) proteins inhibi

112 gulate ectodomain shedding mediated by the A Disintegrin And Metalloproteinase (ADAM) subfamily of pr

113 A disintegrin and metalloproteinase (ADAM)10 and ADAM17 ar

114 We demonstrate that a disintegrin and metalloproteinase (ADAM)10 is the primar

115 downregulation of metalloproteases mainly a disintegrin and metalloproteinase (ADAM)10, ADAM17, ADAM

116 primed B cell increased gene expression of a disintegrin and metalloproteinase (ADAM)10, which is the

117 wo major transmembrane metalloproteinases, a disintegrin and metalloproteinase (ADAM)17 and ADAM10, a

118 ch as matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase (ADAMs), are critical

119 Membrane CD23 is cleaved by a disintegrin and metalloproteinase 10 (ADAM10) and this c

120 A disintegrin and metalloproteinase 10 (ADAM10) is a ubiqu

121 A disintegrin and metalloproteinase 10 (ADAM10) is a zinc-

122 B cell A disintegrin and metalloproteinase 10 (ADAM10) is require

123 ected from skin and lung fibrosis and that a disintegrin and metalloproteinase 10 (ADAM10) is the maj

124 The proteolytic activity of a disintegrin and metalloproteinase 10 (ADAM10) regulates

125 A disintegrin and metalloproteinase 10 (ADAM10), a disinte

126 viously described mice lacking endothelial a disintegrin and metalloproteinase 10 (ADAM10), a key reg

127 es expression of the alpha toxin receptor, a disintegrin and metalloproteinase 10 (ADAM10).

128 how that TACI is sequentially processed by a disintegrin and metalloproteinase 10 and gamma-secretase

129 In addition, we found that a disintegrin and metalloproteinase 10 expression is upreg

130 estingly, the drug-induced upregulation of a disintegrin and metalloproteinase 10 on MM cells is asso

131 TACI proteolysis involved shedding by a disintegrin and metalloproteinase 10 releasing sTACI fro

132 by the alpha- and beta-secretases ADAM10 (a disintegrin and metalloproteinase 10) and BACE1 (beta-si

133 ADAM10 (a disintegrin and metalloproteinase 10) is the principal a

134 sintegrin and metalloproteinase 17 but not a disintegrin and metalloproteinase 10, respectively, whic

135 d high levels of the FcepsilonRII sheddase a disintegrin and metalloproteinase 10, which implies that

136 phiregulin, independent of metalloprotease a disintegrin and metalloproteinase 17 (ADAM17) activity.

137 A disintegrin and metalloproteinase 17 (ADAM17) is a membr

138 els of senescence that the metalloprotease A disintegrin and metalloproteinase 17 (ADAM17) is activat

139 f integrin ligation, the metalloproteinase A disintegrin and metalloproteinase 17 (ADAM17) sheds L-se

140 evious studies showed that inactivation of A disintegrin and metalloproteinase 17 (ADAM17), a membran

141 viously shown that epidermal deficiency of a disintegrin and metalloproteinase 17 (ADAM17), the princ

142 onse to TSST-1 that includes the sheddase, a disintegrin and metalloproteinase 17 (ADAM17).

143 Dysregulated activity of A Disintegrin And Metalloproteinase 17 (ADAM17)/TNFalpha C

144 Indeed, inhibition of gamma-secretase and a disintegrin and metalloproteinase 17 but not a disintegr

145 embrane-anchored metalloproteinase ADAM17 (a disintegrin and metalloproteinase 17) in endothelial cel

146 ADAM17 (a disintegrin and metalloproteinase 17) is ubiquitously ex

147 n kinase C-dependent activation of ADAM17 (a disintegrin and metalloproteinase 17).

148 ADAM17 (a disintegrin and metalloproteinase 17, also referred to a

149 We found that a disintegrin and metalloproteinase 22 (ADAM22) is a compo

150 A disintegrin and metalloproteinase 8 (ADAM8) has been ide

151 A disintegrin and metalloproteinase 8 (ADAM8) is involved

152 The transmembrane ADAM8 (A Disintegrin And Metalloproteinase 8) protein is abundant

153 ng of HB-EGF by TNFalpha-converting enzyme/a disintegrin and metalloproteinase 9 (ADAM9) and ADAM17.

154 PS/TLR4-mediated generation of sMER required disintegrin and metalloproteinase ADAM17 and was indepen

155 proteinases (MMPs) and proteins containing a disintegrin and metalloproteinase domain (ADAM) are impo

156 A disintegrin and metalloproteinase domain 10 (ADAM10) is

157 A disintegrin and metalloproteinase domain 10 (Adam10), a

158 heir plasma membrane expression of ADAM17 (a disintegrin and metalloproteinase domain 17), an enzyme

159 proteinases matrix metalloproteinase-9 and a disintegrin and metalloproteinase domain-8.

160 Palpha during inflammation is regulated by a disintegrin and metalloproteinase domain-containing prot

161 eases responsible for ectodomain shedding is disintegrin and metalloproteinase domain-containing prot

162 A disintegrin and metalloproteinase domain-containing prot

163 p40 up-regulates a disintegrin and metalloproteinase domain-containing prot

164 eucine-rich, glioma-inactivated 1 (LGI1) and disintegrin and metalloproteinase domain-containing prot

165 A disintegrin and metalloproteinase domain-containing prot

166 iotensin-converting enzyme-sheddase ADAM9 (a disintegrin and metalloproteinase domain-containing prot

167 ress or a chemical agonist Yoda1 activated a disintegrin and metalloproteinase domain-containing prot

168 anded from a single, deeply conserved adam28 disintegrin and metalloproteinase gene, to as many as 31

169 Genetic truncation of the transmembrane disintegrin and metalloproteinase protein ADAM11 resulte

170 tudies have elucidated the significance of a disintegrin and metalloproteinase proteins (ADAMs) in PN

171 ntegrin and metalloproteinase 10 (ADAM10), a disintegrin and metalloproteinase that resides in the po

172 ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin

173 hrough continuous proteolysis by ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin

174 adults and mice have implicated ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin

175 lecular-weight rVWF multimers by ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin

176 pathy caused by an inherited deficiency of a disintegrin and metalloproteinase with a thrombospondin

177 Deficiency of a disintegrin and metalloproteinase with a thrombospondin

178 ly in patients with nondeficient ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin

179 opment of autoantibodies against ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin

180 family of extracellular proteases (called a disintegrin and metalloproteinase with thrombospondin mo

181 The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin mo

182 in the development of osteoarthritis, and a disintegrin and metalloproteinase with thrombospondin mo

183 A disintegrin and metalloproteinase with thrombospondin mo

184 ggrecan, matrix metalloproteinases (MMPs), a disintegrin and metalloproteinase with thrombospondin mo

185 a-inducible factor-2alpha, syndecan-4, and a disintegrin and metalloproteinase with thrombospondin mo

186 ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin mo

187 ADAMTS16 (a disintegrin and metalloproteinase with thrombospondin mo

188 lly, fewer beta-catenin, pSMAD2-, pSMAD3-, a disintegrin and metalloproteinase with thrombospondin mo

189 oproteinase family that cleaves lecticans, a disintegrin and metalloproteinase with thrombospondin mo

190 f1), an endosulfatase gene, and CG4096, an A Disintegrin And Metalloproteinase with ThromboSpondin mo

191 A disintegrin and metalloproteinase with thrombospondin mo

192 osteoarthritis include metalloproteinases, a disintegrin and metalloproteinase with thrombospondin mo

193 m whereby two distinct metalloproteinases, a disintegrin and metalloproteinase with thrombospondin mo

194 agens by metalloproteinases of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin mo

195 Aggrecanases of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin mo

196 y microenvironment release factors such as a disintegrin and metalloproteinase with thrombospondin mo

197 ecent studies have implicated the protease a disintegrin and metalloproteinase with thrombospondin mo

198 The metalloproteinase ADAMTS-5 (A disintegrin and metalloproteinase with thrombospondin mo

199 ch as matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin mo

200 A disintegrin and metalloproteinase with thrombospondin mo

201 e Yeast Two-Hybrid approach, we identified a disintegrin and metalloproteinase with thrombospondin re

202 MAs often associated with severe ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin ty

203 strings are naturally cleaved by ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin ty

204 helial activation and dysfunction, whereas a disintegrin and metalloproteinase with thrombospondin ty

205 to the structure and function of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin-1

206 g for 9 months and correlating with higher a disintegrin and metalloproteinase with thrombospondin-13

207 thrombospondin-13 activity and lower anti-a disintegrin and metalloproteinase with thrombospondin-13

208 Conversely, the alpha-secretase "a disintegrin and metalloproteinase" 10 (ADAM10) cleaves A

209 ADAM17, a prominent member of the 'Disintegrin and Metalloproteinase' (ADAM) family, contro

210 age of membrane-anchored proteins by ADAM (a disintegrin and metalloproteinase) endopeptidases plays

211 idate the role of key members of the ADAM (a disintegrin and metalloproteinase) enzyme family, as wel

212 similar to proteins belonging to the ADAM (a disintegrin and metalloproteinase) family, known to proc

213 Like other members of the ADAM (a disintegrin and metalloproteinase) family, the integrin-

214 ADAMs (a disintegrin and metalloproteinase) have important roles

215 Wild-type and Adam (A Disintegrin And Metalloproteinase) knockout mice were ex

216 RECK release disinhibits ADAM (a disintegrin and metalloproteinase) protease-dependent sh

217 ADAM15, a disintegrin and metalloproteinase, is capable of counter

218 Inactivation of ADAM17, a disintegrin and metalloproteinase, with a specific inhib

219 nd factor (VWF) cleaving enzyme, ADAMTS13 (a disintegrin and metalloproteinase, with a thrombospondin

220 s of matrix metalloproteinase-7 (MMP7) and a disintegrin and metalloproteinase-12 (ADAM12) in alpha(1

221 A Disintegrin and Metalloproteinase-15 (ADAM15) is a trans

222 lls that is cleaved by the metalloprotease a disintegrin and metalloproteinase-17 upon stimulation.

223 ates the TNF-alpha convertase enzyme (TACE/a disintegrin and metalloproteinase-17), leading to activa

224 receptor (EGFR) ligand shedding by ADAM17 (a disintegrin and metalloproteinase-17).

225 To determine whether a disintegrin and metalloproteinase-8 (Adam8) regulates al

226 matrix-specific manner and is required for a disintegrin and metalloproteinase-mediated shedding of t

227 Expression of a disintegrin and metalloproteinases (ADAMs) 10 and 17, wh

228 t proteases with Cad6B in vitro shows that a disintegrin and metalloproteinases (ADAMs) ADAM10 and AD

229 A disintegrin and metalloproteinases (ADAMs) are a family

230 A Disintegrin and Metalloproteinases (ADAMs) are the princ

231 omain cleavage of cell-surface proteins by A disintegrin and metalloproteinases (ADAMs) is highly reg

232 beta-site amyloid cleaving enzyme (Bace1), A disintegrin and metalloproteinases (Adams), and presenil

233 m the cell surface was mediated in part by a disintegrin and metalloproteinases 10 and 17.

234 Meprin beta induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by spec

235 Matrix metalloproteinases and a disintegrin and metalloproteinases are members of the zi

236 atrix metalloproteinases) and the related "a disintegrin and metalloproteinases" (ADAMs) promote tumo

237 ADAMs (a disintegrin and metalloproteinases) are a family of mult

238 fect on matrix metalloproteinase (MMP)-13, a disintegrin and MMP with thrombospondin motifs (ADAMTS)-

239 ADAMTS-5 truncates comprising the disintegrin and/or catalytic domains were able to compet

240 his investigation addressed the paradox that disintegrins and small RGD-ligands readily bind to the r

241 One of the proteases is the a-disintegrin-and-metalloprotease 10 (ADAM10) which acts a

242 Endothelial-specific reduction of a disintegrin-and-metalloprotease-domain-10 (Adam10) and i

243 ife-essential molecules from precursors by a-disintegrin-and-metalloproteases (ADAMs) is regulated wi

244 We also found that MMP8 cleaved a-disintegrin-and-metalloproteinase-domain-10 and that MMP

245 Knockdown of MMP8 or incubation with the a-disintegrin-and-metalloproteinase-domain-10 inhibitor GI

246 10 and that MMP8 deficiency reduced mature a-disintegrin-and-metalloproteinase-domain-10 on SPCs.

247 xpression levels of ADAM8, a metalloprotease disintegrin, are correlated with poor clinical outcome.

248 a non-protease member of the ADAM family of disintegrins, as a direct estrogen receptor (ER)-indepen

249 analysis of ADAM17 revealed that within its disintegrin/cysteine-rich region are two highly conserve

250 f migration by ADAM9-L requires a functional disintegrin domain and integrin binding.

251 matrix metalloproteinase (MT1-MMP), ADAMs (a disintegrin domain and metalloproteinases), and gamma-se

252 -like domain being regulatory and two in the disintegrin domain being structural.

253 egrins alpha6 and beta1 bind to TACE via the disintegrin domain but also that mechanical strain enhan

254 DAM) proteins inhibit reprogramming, and the disintegrin domain of ADAM29 is necessary and sufficient

255 mpetitive inhibitor of human ADAM9 catalytic/disintegrin domain with an overall inhibition constant o

256 nsists of a prodomain, a catalytic domain, a disintegrin domain, and a membrane-proximal domain as we

257 361, designed by structural modelling of the disintegrin domain, prevents ADAM8 multimerization.

258 ring domain, the cysteine-rich domain, and a disintegrin domain, respectively.

259 itional O-fucosylation site was found in the disintegrin domain.

260 membrane-proximal stalk, cysteine-rich, and disintegrin domains of ADAM10 mediated its co-immunoprec

261 quirements for the stalk, cysteine-rich, and disintegrin domains.

262 similar to (resting) integrin binding to the disintegrin echistatin.

263 Using disintegrins, echistatin, and VLO4, peptide inhibitors t

264 ow that ADAM11, a transmembrane noncatalytic disintegrin, is the first reported Kv1-interacting prote

265 The proximal metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C)

266 ultidomain protein with metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C)

267 has a short propeptide, metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C)

268 lthough UL-VWF is proteolysed by ADAMTS13 (a disintegrin-like and metalloprotease domain with thrombo

269 etermined that mice deficient in ADAMTS5, (A Disintegrin-like And Metalloprotease domain with Thrombo

270 cluding matrix metalloproteases (MMPs) and a disintegrin-like and metalloprotease with thrombospondin

271 -1beta and a resultant increase in ADAMTS (a disintegrin-like and metalloprotease with thrombospondin

272 activity of VWF is modulated by ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin

273 tly, we reported a gene network of ADAMTS (A Disintegrin-like and Metalloprotease with Thrombospondin

274 ealed that a significant number of ADAMTS (a disintegrin-like and metalloproteinase (reprolysin type)

275 beta domain of the versican-V1 variant by a disintegrin-like and metalloproteinase domain with throm

276 ADAMTS (A Disintegrin-like and Metalloproteinase domain with Throm

277 ADAMTS5 is a member of the A Disintegrin-like And Metalloproteinase with ThromboSpond

278 Adamts16 encodes a disintegrin-like and metalloproteinase with thrombospond

279 LOC306664 is predicted to translate into A Disintegrin-like and Metalloproteinase with Thrombospond

280 ADAMTS (a disintegrin-like and metalloproteinase with thrombospond

281 ADAMTS-4 (a disintegrin-like and metalloproteinase with thrombospond

282 The discovery of a disintegrin-like and metalloproteinase with thrombospond

283 CM enzyme ADAMTS5, a member of the ADAMTS (A Disintegrin-like and Metalloproteinase with Thrombospond

284 tivity and protein expression of ADAMTS13 (a disintegrin-like and metalloproteinase with thrombospond

285 ated a recombinant soluble version of the gB disintegrin-like domain (gB-DLD).

286 Mimicry of the ADAM family disintegrin-like domain by HCMV gB represents a novel me

287 Thereafter, binding of the ADAMTS13 disintegrin-like domain exosite to VWF allosterically ac

288 sequence similarity to the integrin-binding disintegrin-like domain found in the ADAM (a disintegrin

289 fy the surface provided by the catalytic and disintegrin-like domains of ADAMTS-5 as a legitimate tar

290 interact, and showed that the catalytic and disintegrin-like domains support these intermolecular in

291 Here, we report that melittin activates disintegrin-like metalloproteases (ADAMs) and that downs

292 A disintegrin-like metalloproteinase with thrombospondin m

293 loy some combination of ancillary C-terminal disintegrin-like, thrombospondin-1, cysteine-rich, and s

294 and cellular prion (PrP(c)) undergo similar disintegrin-mediated alpha-secretase cleavage yielding N

295 Disintegrin metalloproteases (Adam) can manipulate the s

296 etalloproteinase inhibitors or antibodies to disintegrin metalloproteinase 8 (ADAM8), a major eosinop

297 inal 385-amino acid fragment of ADAMTS-18 (a disintegrin metalloproteinase with thrombospondin motifs

298 n of the disulfide-isomerase ERp5 and of the disintegrin-metalloproteinase ADAM10, able to shed the l

299 oteinases (MMPs) and the related families of disintegrin metalloproteinases (ADAMs) and ADAMs with th

300 tion across the four most abundant proteins (disintegrins, phospholipase A(2)'s, serine proteinases,