ライフサイエンスコーパス: dismutation

1 e optimal catalytic efficiency in superoxide dismutation.

2 ion of superoxide (65-88%) is not undergoing dismutation.

3 n, 2 common target genes involved in radical dismutation.

4 -aerobic respiration and fermentative malate dismutation.

5 for the electrostatic facilitation of O(2)() dismutation.

6 atic contribution to the catalysis of O(2)() dismutation.

7 to O(-.2), which generated H(2)O(2) through dismutation.

8 bition of Y34F during the catalysis of O-(2) dismutation.

9 hemoglobin autoxidation because of its rapid dismutation.

10 ark oxygen is produced in situ via microbial dismutation.

11 ed that the rate of Cygb-mediated superoxide dismutation (1.6 x 10(8) M(-1) . s(-1)) was only ~10-fol

12 g-lived mutants in C. elegans utilize malate dismutation, a byproduct of which is the generation of f

13 activity of MbFeIII, thus facilitating H2O2 dismutation accompanied by O2 evolution and providing pr

14 ne copper ion per subunit and have identical dismutation activities.

15 This small residual H2O2-dismutation activity is attributed to adventitious metal

16 free radical-generating activity, while its dismutation activity is identical to that of the wild-ty

17 sidue is detrimental to the chlorination and dismutation activity of chloroperoxidase.

18 are not associated with the reduction in the dismutation activity of the mutant enzyme.

19 Although the H2O2-dismutation activity was completely eliminated by these

20 le exhibited only 0.02% of the original H2O2-dismutation activity when assayed in the presence of 20

21 -free PSII membranes did not induce any H2O2-dismutation activity.

22 ne copper ion per subunit and have identical dismutation activity.

23 during proteolysis and must be detoxified by dismutation and polymerization, respectively.

24 factors influence energy metabolism, radical dismutation, and expression of survival proteins.

25 The O2*- was converted to H2O2 by dismutation, and the H2O2 was detoxified by accelerated

26 necessary for maximal activity in superoxide dismutation, appears to have no role in stabilization an

27 maximal velocity of catalysis of superoxide dismutation as compared with wild type.

28 esults with respect to the mechanism of O2*- dismutation by MnSOD are discussed.

29 pothesized this was enabled through chlorite dismutation by the community, as most strains in the Bar

30 ase in the catalysis by Mn-SOD of superoxide dismutation can be reached through both the forward (O-(

31 known, was particularly effective as a cross-dismutation catalyst.

32 d rates of intracellular O2- production, O2- dismutation, dehydratase inactivation, and enzyme repair

33 At high [O(2)(-)], the dismutation efficiencies of the yeast MnSODs surpass tho

34 ratios of enzyme to superoxide radical, the dismutation efficiencies scaled as Drad MnSOD > E. coli

35 erified the beneficial effects of superoxide dismutation in cells, we then evaluated the effects usin

36 superoxide kills cells entirely through its dismutation into H(2)O(2).

37 lecular oxygen into superoxide, which, after dismutation into peroxide, serves as the substrate for t

38 d Fe(2+)-Cygb, respectively, suggesting that dismutation involves iron redox cycling, and this was co

39 duction in the hydrophobic heme pocket where dismutation is slow.

40 mal hydrogen electrode, whereas the rates of dismutation (kcat) are 6.0 x 10(7), 4.1 x 10(6), and 3.8

41 d FLP-1 secretion that is dependent upon ROS dismutation, mitochondrial calcium influx, and cysteine

42 e chloride channel(s) and that SOD1-mediated dismutation of *O(2)(-) at the endosomal surface may pro

43 The slow phase is dismutation of a pair of molecules of two-electron reduc

44 es were recently shown to catalyze the cross-dismutation of alkylperoxyl and hydroperoxyl radicals, m

45 etry results, Cld is highly specific for the dismutation of chlorite to chloride and dioxygen with no

46 homogeneous electron distribution due to the dismutation of formal oxidation numbers as compared with

47 During dismutation of H2O2, [TPL] and [MbFeIV] remained constan

48 yme superoxide dismutase (SOD) catalyzes the dismutation of highly reactive O2 (-) into H2O2 and thus

49 oxidase-specific substrate, and catalase for dismutation of hydrogen peroxide generated in the enzyme

50 r manganese cluster that catalyzes the redox dismutation of hydrogen peroxide, interconverting betwee

51 Dismutation of mROS by manganese superoxide dismutase ov

52 r (Cu) antioxidant enzyme that catalyzes the dismutation of O(2)(*-) to H(2) O(2) whose activity requ

53 H(2)O(2) was generated in part by dismutation of O(2)(.) and served as a precursor for OH.

54 he formation of .OH adducts from spontaneous dismutation of O-2 and concomitant reaction with H2O2.

55 ensity of the .OH adduct by accelerating the dismutation of O-2.

56 H2O2 in bolus or generated from the dismutation of O2- by SOD, was cytotoxic at high concent

57 l of cellular superoxide anion (O2-.) is the dismutation of O2-. to hydrogen peroxide by the enzyme s

58 ndrial function (attenuated capacity for the dismutation of reactive oxygen species) and diminished i

59 is the antioxidant enzyme that catalyzes the dismutation of superoxide (O2*-) to O2 and H2O2.

60 the enhancing capacity of Cu/Zn-SOD, and the dismutation of superoxide anion radicals generated from

61 ine of antioxidant defense by catalyzing the dismutation of superoxide anion radicals to form hydroge

62 se A (sodA, bb0153), an enzyme mediating the dismutation of superoxide anions and examined the in vit

63 their enzymic activities for catalyzing the dismutation of superoxide anions and the generation of f

64 SOD, which catalyses the dismutation of superoxide into hydrogen peroxide, should

65 anion accelerates this reaction because the dismutation of superoxide leads to increased levels of h

66 t to the accepted mechanism of SOD catalysed dismutation of superoxide operates, with Cu(I) oxidation

67 Superoxide dismutases (SODs) catalyze the dismutation of superoxide radicals in a broad range of o

68 Superoxide dismutase 2 (SOD2) catalyzes the dismutation of superoxide to hydrogen peroxide in mitoch

69 Its primary function is catalysing the dismutation of superoxide to O(2) and H(2)O(2).

70 , an enzyme that induces the rapid catalytic dismutation of superoxide to the less reactive H(2)O(2)

71 entadecane (MnBAM) effectively catalyzed the dismutation of superoxide with catalytic rate constants

72 which were caused by proton consumption upon dismutation of superoxide, followed by activation of a v

73 oxide radical and the H2O2 produced from the dismutation of superoxide, respectively, and thus preven

74 In a concerted effort, SOD will catalyze the dismutation of superoxide, resulting in the elimination

75 nd Fe(II) ions are capable of catalyzing the dismutation of superoxide, solutions of Ni(II) are not.

76 determined rate constants for the catalytic dismutation of superoxide.

77 Dehydroascorbic acid is generated by dismutation of the ascorbyl free radical, and thioredoxi

78 and showed a hydride transfer which led to a dismutation of the intermediate species.

79 ion markTrx-SOD is capable of catalyzing the dismutation of the superoxide anion; comparative studies

80 xide dismutase ( SOD1 ), which catalyses the dismutation of the superoxide radical to hydrogen peroxi

81 eroxide dismutase (SOD), which catalyzes the dismutation of the superoxide radical, is present in the

82 O2*) trapping by CPCOMPO and the spontaneous dismutation of this radical in aqueous media.

83 ric metal-binding enzyme responsible for the dismutation of toxic superoxide to hydrogen peroxide and

84 Since catalase is a key enzyme for the dismutation of virus-mediated generation of hydrogen per

85 that Cygb exhibits a high rate of superoxide dismutation on the order of 10(8) M(-1) . s(-1) Spin-tra

86 rties of some nitroxides, we probed if cross-dismutation operates in phospholipid bilayers and cell c

87 ADPH oxidase-derived superoxide, but not its dismutation product H2O2.

88 nt formation of superoxide (O2 (.-)) and its dismutation product hydrogen peroxide (H2O2) as determin

89 inverted question markTrx-SOD catalyzes the dismutation reaction at a rate on the order of 10(5) M-1

90 dentified as a major source of the dark H2O2-dismutation reaction in PSII membrane samples.

91 In the presence of excess NADH, this dismutation reaction is followed by the rapid reaction o

92 e fast component appears to correlate with a dismutation reaction occurring with the flavin.

93 the structural changes that occur during the dismutation reaction of hydrochlorofluorocarbon-22 (CHCl

94 sequent kinetic measurements reveal that the dismutation reaction proceeds in two discrete steps and

95 proposed to generate singlet oxygen through dismutation reaction, resulting in a low yield of (1)O(2

96 s subsequently undergo an enzyme-independent dismutation reaction, the rate of which is decreased whe

97 6-13) than be accounted for by simple O2(-) dismutation (RH/RH2O2 = 2), implying a significant oxida

98 (2), produced as a consequence of superoxide dismutation, stimulates vascular cell proliferation and

99 alternate energy production pathway, malate dismutation, that is operative in these animals.

100 , mitochondrial anion channels and cytosolic dismutation to H2O2 may be important steps for oxidant i

101 eroxide, either directly or through its self-dismutation to H2O2, is likewise believed to be a cell-s

102 ese and in efficient catalysis of superoxide dismutation to oxygen and hydrogen peroxide.

103 robic processes like fermentation and malate dismutation to produce energy from carbohydrate.

104 O(2)(*) (-) is believed to undergo primarily dismutation to produce hydrogen peroxide (H(2)O(2)).

105 hydrogen peroxide, the product of superoxide dismutation, to target tumor cells in preclinical xenogr

106 (-1), suggesting that cvSOD-catalyzed O2 (-) dismutation was not a diffusion controlled encounter.