ライフサイエンスコーパス: disorder

1 he basis of some similarities with the human disorder.

2 ignificant relationship with Autism Spectrum Disorder.

3 such as addiction and post-traumatic stress disorder.

4 the other on the pathophysiology of bipolar disorder.

5 in pharmacotherapy for post-traumatic stress disorder.

6 ess disorder (PTSD) may inform risk for this disorder.

7 ecurrent and single-episode major depressive disorder.

8 MCAS-T) may not necessarily have a clonal MC disorder.

9 mechanism to cause this fatal mitochondrial disorder.

10 t typically observed in CKD-mineral and bone disorder.

11 ecognised as a new type of neuroinflammatory disorder.

12 approach for novel interventions in bipolar disorder.

13 posi's sarcoma and other lymphoproliferative disorders.

14 en implicated in autoimmune and inflammatory disorders.

15 th cell alertness to pathogens in intestinal disorders.

16 ndex (BMI), smoking, education, and previous disorders.

17 e subsequent development of neuropsychiatric disorders.

18 y, depressive, personality, or substance use disorders.

19 ildhood compared with most other psychiatric disorders.

20 ociated with many metabolic and neurological disorders.

21 es, dysfunction of which contributes to many disorders.

22 function is associated with neuropsychiatric disorders.

23 dilated cardiomyopathy (DCM) and conduction disorders.

24 importance in Parkinson Disease and related disorders.

25 approach for targeting cancer and metabolic disorders.

26 velopmental issues including autism spectrum disorders.

27 ating these proteins in various neurological disorders.

28 c lead for the treatment of neuropsychiatric disorders.

29 C), have been found in different psychiatric disorders.

30 tify the neurobiological principles of brain disorders.

31 rated differing inference for 11/30 (30.67%) disorders.

32 t in efficient treatment of social-emotional disorders.

33 cluded patients with other neurodegenerative disorders.

34 ciliopathies, a heterogeneous group of rare disorders.

35 disturbance in specific DSM anxiety-related disorders.

36 therapeutic effects in specific psychiatric disorders.

37 ve deficits commonly observed in psychiatric disorders.

38 c diseases such as obesity and substance use disorders.

39 pplicable in other rare childhood ophthalmic disorders.

40 t children and adults with neurodegenerative disorders.

41 was validated in patients with neurological disorders.

42 betes mellitus, obesity, amnesia among other disorders.

43 ent paradigm for ALS, SBMA, SMA, and related disorders.

44 tially independent from comorbid psychiatric disorders.

45 e to other MDD subtypes or other psychiatric disorders.

46 allmark of the pathology of gastrointestinal disorders.

47 rinucleotides that lead to neurodegenerative disorders.

48 l malignancies or chronic myeloproliferative disorders.

49 leading cause of infertility and congenital disorders.

50 provide therapeutic targets for neurological disorders.

51 d targets for treatment of pediatric anxiety disorders.

52 neuroanatomy and disruptions in psychiatric disorders.

53 ncluding lung, renal, and neurodevelopmental disorders.

54 uring and for managing quantitative platelet disorders.

55 ding of the sequelae for several psychiatric disorders.

56 ation is elevated in cancer and neurological disorders.

57 explanatory biological models of psychiatric disorders.

58 n, and affected cell types seen across these disorders.

59 assessment in individuals affected by these disorders.

60 opment of treatments for age-related hearing disorders.

61 ffective and stress-related neuropsychiatric disorders.

62 ted cells contributes to a broad spectrum of disorders.

63 ctor g(abs) , although the system is overall disordered.

64 Huntington's disease and several psychiatric disorders(1,2).

65 increase prevalence of posttraumatic stress disorder (52.4% vs 37.1%; p = 0.03).

66 ary objective when treating major depressive disorder-a disease that afflicts ~20% of the world's pop

67 e disorder (MDD) is a serious, heterogeneous disorder accompanied by brain-related changes, many of w

68 symptoms of attention deficit hyperactivity disorder (ADHD) and associated cognitive anomalies, part

69 Attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obs

70 be epilepsy (MTLE) is a chronic neurological disorder affecting almost 40% of adult patients with epi

71 s imperfecta (AI) is a collection of genetic disorders affecting the quality and/or quantity of tooth

72 The disorder affects people of all ages and ethnicities, has

73 The pooled prevalence rates for mental disorders among FSWs in LMICs were as follows: depressio

74 amilial Alzheimer's disease, autism spectrum disorder and multiple sclerosis.

75 ifferent survival probabilities for prostate disorder and prostatitis, but not for BPH, were observed

76 ent major depressive disorder (MDD), bipolar disorder and schizophrenia would enhance statistical pow

77 ball-milled samples, underlining the sodium disorder and showing that a local tetragonal framework m

78 icate that the ETSs are relatively robust to disorder and this may have practical ramifications.

79 ecruiting gp41 to the boundary of the liquid-disordered and liquid-ordered phases to incur membrane c

80 The structure is intrinsically disordered and therefore remains poorly characterized.

81 nomic gameplay studies in Axis 1 psychiatric disorders and advocates the use of these games as measur

82 signaling is implicated in neurodegenerative disorders and cancers.

83 pathogenesis of some autoimmune neurological disorders and could even contribute to neurodegenerative

84 , demonstrated its involvement in non-injury disorders and found multiple ways to block it.

85 information processing in pediatric anxiety disorders and highlight the particular value of this con

86 ethod can be used in studying multiple brain disorders and injuries, e.g., in Parkinson's disease or

87 underlying rheumatologic or autoinflammatory disorders and is usually designated macrophage activatio

88 , the GBM is affected by acquired autoimmune disorders and metabolic diseases such as diabetes mellit

89 are strongly associated with autism spectrum disorders and neural circuit changes in several brain ar

90 thologies associated with neurodevelopmental disorders and neurodegenerative diseases.

91 pairments characterize numerous neurological disorders and neurogenetic syndromes, such as autism spe

92 National Institute of Neurological Disorders and Stroke for the randomisation phase and Vit

93 ge of cases associated with specific genetic disorders and the proportion of variants that were inher

94 iseases including metabolic and inflammatory disorders and tumorigenesis.

95 s that have been implicated in human bipolar disorder, and changes in intestinal microbiota.

96 erative diseases, metabolic and inflammatory disorders, and cancer.

97 ring trios of individuals with developmental disorders, and develop a simulation-based statistical te

98 degeneration and other related degenerative disorders, and the normal functions of Vn, especially th

99 honon quasiparticles by anharmonicity and Ag disorder are the origin of intrinsically low [Formula: s

100 Polyglutamine (polyQ) disorders are a group of nine neurodegenerative diseases

101 Many neurodevelopmental disorders are characterized by impaired functional synap

102 Functional abdominal pain disorders are common disorders with a prevalence of 3-16

103 Substance abuse disorders are linked to alteration of circadian rhythms,

104 vention and management of major neurological disorders are not sufficiently effective to counter glob

105 sts that individuals with glucose metabolism disorders are susceptible to mortality associated with f

106 Anxiety disorders are the most common form of mental illness and

107 patients that suffer from neurodegenerative disorders, are orphans from a structural point of view,

108 , we selected beta-thalassemia, a hemoglobin disorder, as a paradigm.

109 rogenetic syndromes, such as autism spectrum disorder (ASD) and Dravet, Fragile X, Prader-Willi, Turn

110 istently in individuals with autism spectrum disorder (ASD) and their families, including the presenc

111 Autism spectrum disorder (ASD) has been hypothesized to be a result of t

112 iological heterogeneity like Autism Spectrum Disorder (ASD) often pose a challenge for traditional ge

113 peractivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD)

114 Genes that are mutated in Autism Spectrum Disorders (ASD) can be classified broadly as either syna

115 F1) is a common monogenic neurodevelopmental disorder associated with physical and cognitive problems

116 facilitates PD pathologies and elicits motor disorders associated with augmentation of delta-secretas

117 nomic consequences of coexisting alcohol use disorder (AUD) in patients with cirrhosis, little is kno

118 portant to identify individuals having these disorders because, unlike patients with sporadic cancer,

119 Obstructive sleep-disordered breathing (SDB), which includes primary snori

120 osition bias is often associated with LC and disorder, but repeats, while compositionally biased, mig

121 h schizophrenia and other neurodevelopmental disorders, but are also a contributing factor to impairm

122 shed therapeutic target in myriad autoimmune disorders, but no TLR7 antagonist is available for clini

123 reased risk of obesity and related metabolic disorders, but the role of sleep in long-term weight los

124 RNA polymerase II (RNA Pol II) contains a disordered C-terminal domain (CTD) whose length enigmati

125 muscular dystrophy, is an autosomal dominant disorder caused by an expansion of a (CTG)n tract within

126 Prion diseases are rare, neurological disorders caused by the misfolding of the cellular prion

127 lammatory (PAMI) syndrome is a novel genetic disorder, causing hypercalprotectinemia and hyperzincemi

128 ndrome (NS) is a multisystemic developmental disorder characterized by common, clinically variable sy

129 Although epilepsy is a dynamic disorder characterized by pathological fluctuations in b

130 nd col4alpha5 knockout AS mice, a hereditary disorder characterized by progressive renal failure.

131 of cortical development are a group of rare disorders commonly manifesting with developmental delay,

132 pectrum disorder, psychosis, and alcohol use disorder compared with the control sample.

133 M-MRI signal in individuals with cocaine use disorder, compared with age- and sex-matched control sub

134 argest GWAS meta-analysis available for this disorder consisting of over 20,000 individuals diagnosed

135 ic correlations revealed that type 2 bipolar disorder correlates strongly with recurrent and single-e

136 r behavioral disinhibition, major depressive disorder, depressive symptoms, autism spectrum disorder,

137 36 patients with first onset of a depressive disorder (Diagnostic and Statistical Manual of Mental Di

138 who met criteria for a past-year alcohol use disorder did.

139 Schizophrenia and bipolar disorder do not appear to share similar mitochondrial al

140 d an epithelial phenotype in CRC cells while disordered ECM drove a mesenchymal phenotype, similar to

141 ly, and degradation by ClpC1, which requires disordered ends in its protein substrates.

142 resent a new therapeutic target for treating disordered energy metabolism metabolic syndrome and type

143 ther or how conformational biases within the disordered ensembles of foldable proteins affect functio

144 Patients with temporomandibular disorders exhibit altered brain networks in widespread c

145 rders (externalizing, internalizing, thought disorder) exhibited highly overlapping patterns of reduc

146 es across three broad diagnostic families of disorders (externalizing, internalizing, thought disorde

147 in the pathology of severe neuropsychiatric disorders, for which effective treatments are still elus

148 The Fragile X-related disorders (FXDs) are Repeat Expansion Diseases, genetic

149 mia syndromes are the most prevalent genetic disorder globally, characterised by reduced or absent be

150 who met criteria for a past-year alcohol use disorder had a psychiatric comorbidity, while only one-t

151 IFICANCE STATEMENT Predisposition to anxiety disorders has both a neurodevelopmental and a genetic ba

152 lcarnitines (ACs), often caused by metabolic disorders, has been associated with obesity, arrhythmias

153 ies in common causes of CKD-mineral and bone disorder have been defined, it is unknown if persistent

154 The clinical presentation and course of the disorder have been extensively characterised.

155 These disorders have other neurological manifestations of cent

156 nes, such as those causing connective tissue disorders, have been implicated; however, the genetic ar

157 Understanding of the genetic basis of this disorder highlights fundamental beta-cell mechanisms.

158 actor for posttransplant lymphoproliferative disorder; however, immune correlates of EBV DNAemia in t

159 tures (eg, rapid eye movement sleep behavior disorder, hyposmia, constipation), characteristic moveme

160 Most risk variants for brain disorders identified by genome-wide association studies

161 n 57%, idiopathic in 29%, MOG-IgG-associated disorder in 5%, AQP4-IgG-seropositive neuromyelitis opti

162 ious species, there is a correlation between disorder in H2 and its contribution to binding affinity,

163 While disorder in the histone tails enables a large variation

164 n (PH) is a life-threatening cardiopulmonary disorder in which inflammation and immunity have emerged

165 ice suggests that treatments for alcohol use disorder in women may need to account for this sex diffe

166 NMR) spectroscopy that Spp2 is intrinsically disordered in solution.

167 ical and genetic prevalence of lipodystrophy disorders in a large clinical care cohort.

168 igher rates of neurodevelopmental and mental disorders in adulthood.

169 fied excess mortality associated with mental disorders in HIV-positive people in South Africa, adjust

170 ogenic forms of neurological and psychiatric disorders in individuals with PNES shows that genetic fa

171 d be extrapolated to other lysosomal storage disorders in which immune response hinders ERT.

172 idated rodent model of post-traumatic stress disorder, in combination with optogenetic activation of

173 dementia (FTD) spectrum of neurodegenerative disorders includes a heterogeneous group of conditions.

174 cell polarity are associated with neurologic disorders including autism and microcephaly.

175 on, however, is evident in many neurological disorders including ischemic stroke, trauma, and chronic

176 Women with inherited bleeding disorders, including carriers of hemophilia A and B, or

177 od of increased vulnerability to psychiatric disorders, including depression.

178 y be a potential target for the treatment of disorders involving memory impairments.SIGNIFICANCE STAT

179 ssociated vasculitides (AAVs) are a group of disorders involving severe, systemic, small-vessel vascu

180 Inherited retinal disorder (IRD) is a leading cause of blindness, and CRX

181 Functional neurological disorder is a common and phenomenologically diverse cond

182 n previous imaging studies showing that this disorder is associated with blunted presynaptic striatal

183 rences in brain structures among psychiatric disorders is important for understanding the pathophysio

184 cal pain, fibromyalgia, and neuropathic pain disorders, is highly prevalent but remains poorly treate

185 sing therapeutic target for neuropsychiatric disorders; its pharmacology, however, remains scarcely u

186 (Diagnostic and Statistical Manual of Mental Disorders IV criteria) diagnosed after the age of 55 (LO

187 For the constellation of neurologic disorders known as chemotherapy-induced peripheral neuro

188 ) inhibitors have the potential to rebalance disordered lipid metabolism, leading to improvements in

189 rticularly neurodegenerative and psychiatric disorders, making it possible to study mechanisms of dis

190 The more complex reality is that a given disorder may be influenced by myriad small-effect noncod

191 participants diagnosed with Major Depressive Disorder (MDD) (n = 64) to healthy controls (n = 64) usi

192 Major depressive disorder (MDD) and Alzheimer's disease (AD) reciprocally

193 l cortices of patients with major depressive disorder (MDD) has been demonstrated using functional ne

194 Major depressive disorder (MDD) is a leading cause of disability worldwid

195 Major depressive disorder (MDD) is a serious, heterogeneous disorder acco

196 self-reported and recurrent major depressive disorder (MDD), bipolar disorder and schizophrenia would

197 tric diseases, particularly major depressive disorder (MDD), remains largely unknown.

198 NA-Seq data from a study of major depressive disorder (MDD), we show that NPDR with covariate adjustm

199 en a clinical challenge for major depressive disorder (MDD).

200 nd quality of life (QoL) in major depressive disorder (MDD).

201 typing and strictly defined major depressive disorder (MDD): the former has a lower genotype-derived

202 ork which studies physical transport through disordered media allows us to formulate precise links be

203 Here, we identify disordered micrometer-size organic phases rather than pr

204 ial organelles are associated with metabolic disorders, neurodegenerative diseases, and aging.

205 gG-seropositive neuromyelitis optic spectrum disorder (NMOSD) in 3%, infectious type in 2%, sarcoidos

206 prescribed in neuromyelitis optica spectrum disorder (NMOSD) patients.

207 Neuromyelitis optica spectrum disorders (NMOSD) are a type of neurological autoimmune

208 s of major depressive disorder or depressive disorder not otherwise specified and no prior diagnosis

209 In studies of anxiety and other affective disorders, objectively measured physiological responses

210 rum disorder (ASD), and obsessive-compulsive disorder (OCD) are common neurodevelopmental disorders t

211 atients with refractory obsessive-compulsive disorder (OCD).

212 ctable serum manganese (Mn) and a Congenital Disorder of Glycosylation (CDG) due to the exquisite sen

213 nulomatous disease (CGD) is a rare inherited disorder of phagocytic cells(1,2).

214 Although CVID is thought to be a disorder of the peripheral B-cell compartment, in 25% of

215 A diverse array of genetic disorders of cholesterol metabolism support this claim a

216 is relevant to our understanding of clinical disorders of consciousness.

217 er Syndrome (WS) and Bloom Syndrome (BS) are disorders of DNA damage repair caused by biallelic disru

218 unction, but its role in placentally related disorders of human pregnancy is unknown(3).

219 MDD was associated with disorders of lipid metabolism (OR 1.22, 95% CI 1.12-1.34

220 with holoprosencephaly and individuals with disorders of sex development, and through international

221 n effective treatment modality for monogenic disorders of the blood system such as primary immunodefi

222 viduals with a diagnosis of major depressive disorder or depressive disorder not otherwise specified

223 Opioid use disorder (OUD) is a chronic, relapsing condition, often

224 at intake, 14 (46.4%) engaged in opioid use disorder (OUD) treatment during therapy, and 9 remained

225 Patients with opioid use disorder (OUD) who are hospitalized for serious infectio

226 imilarities and differences between the mood disorders, particularly in the mouse brain cell types im

227 d in human fibroblasts from major depressive disorder patients.

228 (WAS), an X-linked primary immunodeficiency disorder (PID) resulting from the deficiency of WAS-prot

229 While these results suggests that disorder predictors outperform their current benchmark p

230 mic mice exhibited poor memory abilities and disordered prefrontal-hippocampal functional connectivit

231 usals in patients with sleep apnea and other disorders prevent restful sleep and contribute to cognit

232 omplex structural space of the intrinsically disordered protein alpha-synuclein.

233 urrently with the secondary structure of the disordered protein)-an observation supported by previous

234 rivers of LLPS have shown that intrinsically disordered proteins (IDPs) and nucleic acids like RNA an

235 Interactions between disordered proteins involve a wide range of changes in t

236 The sequence-intrinsic contributions of disordered proteins to phase separation can be discerned

237 nal biases in the ensembles of intrinsically disordered proteins.

238 sorder, depressive symptoms, autism spectrum disorder, psychosis, and alcohol use disorder compared w

239 hanced extinction in a post-traumatic stress disorder (PTSD) animal model and was related to reducing

240 association studies of posttraumatic stress disorder (PTSD) may inform risk for this disorder.

241 TATEMENT Patients with post-traumatic stress disorder (PTSD) show heightened amygdala activity; eleva

242 d reveal how a defined architecture within a disordered region contributes to E3 ligase function.

243 We have considered the disordered region that connects the N- and C-terminal ha

244 Furthermore, proteins with disordered regions were found to adopt significantly les

245 developed for treatment of colonic motility disorders related to use of antibiotics or other factors

246 ve training treatments for pediatric anxiety disorders rely on accurate and reliable identification o

247 However, quantized disorder-resilient transport is observable in the edge c

248 se (AD) is the most common neurodegenerative disorder, resulting in the progressive decline of cognit

249 The neurodevelopmental disorder Rett syndrome is caused by mutations in the gen

250 xcitatory neurons, whereas neurodegenerative-disorder risk genes showed increasing expression over ti

251 Psychiatric-disorder risk genes tended to be expressed during mid-ge

252 amental understanding of redox mechanisms in disordered rocksalt oxyfluorides, highlighting their pro

253 e membrane interactions of the intrinsically disordered SH4 and Unique domains of the Src family kina

254 ations in H2 that do not change the level of disorder show similar binding behavior.

255 individuals with stress- and trauma-related disorders.SIGNIFICANCE STATEMENT Patients with post-trau

256 pectroscopy revealed the presence of largely disordered species and suggested the presence of beta-sh

257 are identified, coined i-MAB, along with 16 disordered stable alloys.

258 tion of M13 converts from a conformationally disordered state to an alpha-helix and develops contacts

259 nality and the general factor of personality disorder, substantive interpretations of p, and the pote

260 oaches for weakening maladaptive memories in disorders such as addiction and post-traumatic stress di

261 acental hypoxia is associated with pregnancy disorders such as intrauterine growth restriction and pr

262 Compared with other psychotic disorders such as schizophrenia, relatively few studies

263 lications for the management of neurological disorders, such as autism and intellectual disability, t

264 Given that risk for fear-related disorders, such as PTSD, is biased toward females, we ex

265 er levels of attention deficit/hyperactivity disorder symptoms.

266 known aetiologies, a range of other movement disorder syndromes may also present with SIBs, even thou

267 Subsequently, a severe and novel pediatric disorder termed multisystem inflammatory syndrome in chi

268 failure has previously been linked to sleep disorders that are often associated with frequent distur

269 disorder (OCD) are common neurodevelopmental disorders that frequently co-occur.

270 FXDs) are Repeat Expansion Diseases, genetic disorders that result from the expansion of a disease-sp

271 ral characteristics with other substance use disorders, that could inform prevention and treatment st

272 NA-seq data from a study of major depressive disorder.The cnCV method has similar training and valida

273 Adjusting for mental disorders, three significant associations, all on chromo

274 , leveraging pathway complexity of molecular disorder to order transition while bridging materials fa

275 lose and sorbitol, the NFAT5 NTD undergoes a disorder-to-order shift, adopting higher average seconda

276 d NMR spectroscopy experiments reveal that a disorder-to-order transition of the ankyrin repeat motif

277 ms that might contribute to fear and anxiety disorders transmission in clinically affected families.

278 as in anti-NMDA receptor encephalitis, sleep disorders vary according to the disease stage along with

279 articipants with chronic whiplash associated disorders (WAD), recovered, and healthy controls.

280 escribed genes associated with developmental disorders, we integrate healthcare and research exome-se

281 saster social capital and symptoms of mental disorders were measured using the Screening Questionnair

282 In anti-IgLON5 disease, sleep disorders were the core symptoms that led to the descrip

283 d as acne inversa) is a chronic inflammatory disorder, which affects the intertriginous skin and is a

284 logical systems associated with cannabis use disorder, which often share common neural characteristic

285 This wide spectrum of disorders, which include dyskeratosis congenita, pulmona

286 task because of the large number of distinct disorders, which requires involvement of patients and bo

287 osis of Down syndrome or other developmental disorder, while 84 (52.5%) individuals had a diagnosis o

288 specified and no prior diagnosis of bipolar disorder, who received at least one of the nine antidepr

289 ression is a seriously disabling psychiatric disorder with a significant burden of disease.

290 ic dermatitis (AD) is a complex inflammatory disorder with multiple interactions between genetic, imm

291 rogressive, pediatric-onset spastic movement disorder with variable clinical presentation.

292 Autism is a heterogeneous collection of disorders with a complex molecular underpinning.

293 nctional abdominal pain disorders are common disorders with a prevalence of 3-16% depending on countr

294 at are similar to changes induced by genetic disorders with devastating neurodevelopmental deficienci

295 ology of schizophrenia and other psychiatric disorders with developmental origins.

296 Neurological disorders with IgG antibodies against myelin-oligodendro

297 athway as a potential therapeutic target for disorders with reduced SHANK3 dosage, provide a rich res

298 isorders, with disruptive mood dysregulation disorder, with ADHD, or without psychopathology.

299 ncluded treatment-seeking youth with anxiety disorders, with disruptive mood dysregulation disorder,

300 variation of inter-nucleosome arrangements, disorder within the chromatin-binding proteins facilitat

301 hium has been used to treat major depressive disorder, yet the neural circuit mechanisms underlying t