ライフサイエンスコーパス: dispensable

1 sposon silencing, whereas piRNAs are largely dispensable.

2 ses, whereas IFN-gamma, IL-6, and IL-10 were dispensable.

3 Surprisingly, the channel function is dispensable.

4 ination, for which PAXX appeared to be fully dispensable.

5 t different steps, whereas ULK1 and ULK2 are dispensable.

6 periplasmic domain (residues 191 to 586) is dispensable.

7 the sialic acid-binding pocket in F2 appears dispensable.

8 s its various chromatin-binding domains were dispensable.

9 poisomerases, encoded by topA and topB, were dispensable.

10 ssion of the closely related CDK4 protein is dispensable.

11 on, strongly suggesting that 183c miRNAs are dispensable.

12 cellular regions of LptD, but are themselves dispensable.

13 e pathway C3bBb convertase, whereas SCR-1 is dispensable.

14 required, while homo-oligomerization may be dispensable.

15 onserved lncRNAs (gas5 and lnc-setd1ba) were dispensable.

16 ccumulation, while TlpA, TlpC, and TlpD were dispensable.

17 an Rqh1-dependent manner, while Exo1 becomes dispensable.

18 ial for epidermal integrity, whereas PRC2 is dispensable.

19 cise distribution of secreted signals mostly dispensable.

20 tif at the murine Bcl11a enhancer is largely dispensable.

21 y for optimal Treg function while others are dispensable.

22 intestinal epithelial cell-derived IL-33 is dispensable.

23 priming by conventional dendritic cells was dispensable.

24 lse generation by voltage-gated channels are dispensable.

25 Long thought to be dispensable after establishing X chromosome inactivation

26 Interestingly, none of the Wnts are dispensable and act synergistically to induce Chk1.

27 We identified both dispensable and critical NTR nucleotides, as well as hig

28 quences are efficiently transcribed, Csm6 is dispensable and DNA degradation by Cas10 is sufficient f

29 etrin1 deletion suggested that FP-netrin1 is dispensable and VZ-netrin1 sufficient for netrin guidanc

30 at IFN-gamma-driven itaconate production was dispensable, as directly targeting complex II using cell

31 viral replication, the transgene is not only dispensable but may even be detrimental.

32 We found that LDL cholesterol lowering was dispensable, but statin-induced lowering of isoprenoids

33 out cDC2 differentiation, it is surprisingly dispensable during late-stage cDC1 differentiation.

34 sure the obligatory chiasma, AXL seems to be dispensable during meiosis, although its absence slightl

35 Thus, the membrane-spanning domain, while dispensable for a UL138-mediated decrease in MRP1 protei

36 show that CtIP-mediated DNA end resection is dispensable for A-EJ-mediated CSR using cNHEJ-deficient

37 cells, demonstrating that phosphorylation is dispensable for activation and actin regulation.

38 demonstrate that, although MCPH1 function is dispensable for activation and maintenance of the decate

39 er in PMN functions, whereas FcgammaRIIIB is dispensable for activation and phagocytosis.

40 y of the CCHC motifs in the Gag NC domain is dispensable for Alix-mediated rescue of virus budding, s

41 distinct BCR transgenic mouse models but is dispensable for all of these tolerance mechanisms.

42 in other cancers, tumor-expressed MT1-MMP is dispensable for all stages of osteosarcoma progression.

43 mplex and contains distal T domains that are dispensable for allosteric regulation.

44 n at a low multiplicity of infection, but is dispensable for AMPK activation at the earliest times of

45 Thus, the RPT domain is dispensable for amyloid formation as such but shapes the

46 ion of antimicrobial peptide (AMP) genes but dispensable for antiviral RNAi.

47 teracts with APE2 and PCNA, although PCNA is dispensable for APE1's exonuclease activity.

48 portantly, we find that Ppz phosphatases are dispensable for Art1 PM translocation, but are required

49 Although OmpB is dispensable for bacterial growth in endothelial cells, i

50 neutrophil adhesion and spreading, it may be dispensable for beta2 integrin-dependent neutrophil recr

51 Aurora B-INCENP) to centromeres, can become dispensable for bi-orientation [10].

52 that Aurora B localization at centromeres is dispensable for bi-orientation.

53 ochondrial ATP generation, and glycolysis is dispensable for blastocyst formation.

54 e revealed that EphrinB2/EphB4 signalling is dispensable for blood endothelial barrier function, but

55 e primate-specific proline-rich domain to be dispensable for both HSP90 interaction and PDE6 activity

56 or BMP-mediated patterning of the embryo, is dispensable for both ligand-independent signaling pathwa

57 s, being independent of dorsal subiculum and dispensable for both spatial novelty detection and rewar

58 Whereas beta-catenin is dispensable for CAF-mediated ECM remodelling, cancer cel

59 In contrast, PmrAB is dispensable for CAMP resistance in E. cloacae.

60 t, the C-terminal membrane-binding region is dispensable for canonical autophagy but essential for VP

61 Although LRRC8A was dispensable for canonical DAMP-dependent NLRP3 activatio

62 ssical bone-associated osteoclasts, VAOs are dispensable for cartilage resorption and regulate anasto

63 rated that IFN regulatory factor (IRF) 8 was dispensable for caspase-11-mediated NLRP3 inflammasome a

64 and positive inotropy in the heart, but are dispensable for CaV1.2 trafficking to the adult cardiomy

65 However, Cep55 is dispensable for cell division in embryonic or adult tiss

66 ells demonstrates that autonomous 5S rRNA is dispensable for cell growth under standard conditions an

67 Although crh genes are dispensable for cell viability, simultaneous deletion of

68 essential cofactor for viral replication but dispensable for cell viability.

69 anization, yet it is widely considered to be dispensable for cellular function and organismal develop

70 h PLK4-mediated phosphorylation of Ser-78 is dispensable for CEP131 localization, ciliogenesis, and c

71 y reflecting a regenerative response, but is dispensable for chondrocyte proliferation in vivo, and i

72 ent stability and force transduction but are dispensable for chromosome congression.

73 These phosphorylated residues were dispensable for CHT7 function, but phosphorylated varian

74 We observed that INPP4A is dispensable for clathrin-mediated endocytosis and is und

75 ranscripts at the translational level but is dispensable for cleavage-mediated RNA interference and f

76 Contrary to the existing paradigm, actin is dispensable for CME events at the plasma membrane but pl

77 te here that while the TNPO1 binding site is dispensable for CPSF6 nuclear import, the arginine/serin

78 The enzymatic activity of CitA is dispensable for CtrA control, and functional citrate syn

79 er, ECT2 targeting to the central spindle is dispensable for cytokinesis, indicating that how PLK1 co

80 ted de novo methylation in germ cells but is dispensable for de novo methylation during embryogenesis

81 Sin3b in islet beta-cells, with Sin3a being dispensable for differentiation but required for postnat

82 hare a conserved N-terminal sequence that is dispensable for DNA cleavage inhibition and have diverge

83 preference for the leading strand, which is dispensable for DNA replication.

84 ructure on the X chromosome in C. elegans is dispensable for dosage compensation but regulates longev

85 Here we show that Sia is dispensable for early development of the embryo proper b

86 While lack of only one Ral GTPase was dispensable for early peripheral nerve development, abla

87 omenta of Nik(-/-) mice revealed that NIK is dispensable for ectopic kidney vascular integration and

88 In Drosophila, we find that Vps29 is dispensable for embryogenesis but required for retromer

89 r that not only is mitochondrial respiration dispensable for embryonic cartilage development, but als

90 pendently of TRF2, which reveals why TRF2 is dispensable for end protection during pluripotency.

91 g development, while airway smooth muscle is dispensable for epithelial branching, it is integral for

92 ABSC-derived Wnt ligand production was dispensable for epithelial proliferation.

93 -bound PP1 is critical for SAC silencing but dispensable for error correction; in fact, reduced PP1 d

94 terintuitive observation that Klf2, which is dispensable for ESC maintenance, is required during rese

95 DOT1L is dispensable for ESC self-renewal but is required for est

96 be required for autophagosome completion but dispensable for ESCRT-I complex formation and the degrad

97 /CD28 mAb-mediated induction of IL-10 but is dispensable for ex vivo IL-10 expression.

98 f Foxn1 in mouse thymic epithelial cells but dispensable for expression in hair follicles.

99 oice and synaptic partner selection, but are dispensable for fasciculation.

100 In contrast, COX-1 was dispensable for FcepsilonRI-driven CysLT production.

101 Notably, ALOX12 is dispensable for ferroptosis induced by erastin or GPX4 i

102 g that gamma delta T (gammadeltaT) cells are dispensable for FSTL-1 Hypo control of pulmonary infecti

103 Uniquely, ZO-1 is dispensable for function of the working myocardium.

104 because in some stress conditions, s-OPA1 is dispensable for fusion.

105 nduce beta-arrestin coupling, while M153 was dispensable for G protein coupling.

106 d that OGT-1 glycosyltransferase activity is dispensable for GABA neuron function.

107 these results suggest that although IL-23 is dispensable for GC formation, it is essential to promote

108 of six non-core subunits reveals that, while dispensable for global H3K27 methylation levels, the non

109 , here we show that, surprisingly, parkin is dispensable for glucose homeostasis in both beta cells a

110 Although dispensable for growth and initial penetration, OSP24 is

111 n somatic nuclei in vegetative cells, but is dispensable for growth and nuclear division.

112 bacterial secretion systems, was shown to be dispensable for H. pylori-induced inflammasome activatio

113 The Satb1 homeodomain is dispensable for high affinity binding but is essential f

114 ogether, our data suggest that syntaxin-3 is dispensable for hippocampal basal neurotransmission and

115 x and two ESCRT-associated Bro1 proteins are dispensable for HSV-1 replication.

116 ockdown study indicated that PRDM14 might be dispensable for human germ cell fate.

117 nd helps in vivo TasA-fibre formation but is dispensable for in vitro TasA-fibre assembly.

118 cortical neuron dendritic elaboration but is dispensable for inhibitory axon guidance.

119 cle By contrast to previous reports, PAK1 is dispensable for insulin-stimulated glucose uptake in mou

120 the interaction of CLN6 with the enzymes but dispensable for interaction with CLN8.

121 eractions of USP7 with NF-kB subunits but is dispensable for interactions with other proteins.

122 ey component of organoid growth media yet is dispensable for intestinal homeostasis, suggesting roles

123 redominantly expressed in the beta-cells, is dispensable for islet morphogenesis.

124 n, demonstrating that spinal Grp neurons are dispensable for itch transmission.

125 t the N-terminal 10 amino acids of TbCAE are dispensable for its activity and mitochondrial localizat

126 GRF motifs (designated as Zf-GRF repeat) are dispensable for its DNA glycosylase and AP lyase activit

127 The kinase activity of MUS is dispensable for its function in lateral root development

128 found that proteolytic processing of PLD3 is dispensable for its hydrolytic activity.

129 related functions of CREB1/CRH-1 while being dispensable for its innate chemotaxis behavior.

130 T; disulfide bridge formation in FGF23-WT is dispensable for KLA binding and for cell signaling via F

131 row at a normal rate, indicating that LDH is dispensable for larval biomass production.

132 pocampus-dependent memory consolidation, but dispensable for learning, memory retrieval, and reconsol

133 we show that these Vbeta5(+) iTreg cells are dispensable for limiting anti-viral immunity.

134 By contrast, integrins are dispensable for LN homing, yet still contribute by incre

135 Collectively, these data show that GLUT6 is dispensable for LPS-induced M1 polarization and function

136 and histone binding ability of HP1gamma are dispensable for maintaining H3K36me3 levels.

137 nic sprouting in the brain, but surprisingly dispensable for maintaining the blood-brain barrier.

138 SPEN is dispensable for maintenance of XCI in neural progenitors

139 In yeast strains for which IME4 is dispensable for meiosis, a natural polymorphism in the R

140 macrosatellite upon reprogramming but seems dispensable for methylation maintenance.

141 We found that epithelial ROR2 is dispensable for midgut elongation.

142 s required for vascular regeneration, but is dispensable for midvein formation in leaves.

143 idence suggests that the leading edge may be dispensable for migration, raising the question of what

144 B3 are viable-indicating that the protein is dispensable for mitotic divisions-but are sterile.

145 pendent kinetochore assembly pathway that is dispensable for mitotic growth but becomes critical upon

146 mTORC2 appears dispensable for most other AKT actions examined, indicat

147 we demonstrate that while PRDM15 is largely dispensable for mouse adult somatic cell homeostasis in

148 ietic stem cells (HSCs), we found that it is dispensable for mouse and human HSC function.

149 e and in the preimplantation stage embryo is dispensable for mouse development.

150 Here we show that Cep55 is dispensable for mouse embryonic development and adult ti

151 data provide genetic evidence that Fndc5 is dispensable for muscle development and basal metabolism

152 Whereas MDR1 was dispensable for naive CD8+ T cell development, it was re

153 hematopoietic cell-derived Gdf11 is largely dispensable for native and transplant-induced blood form

154 s, the actin-binding domain of Nesprin-2 was dispensable for neuronal migration.

155 KLF12 was dispensable for NK cell development, IFN-gamma productio

156 ential for breast cancer cell growth, but is dispensable for normal cell proliferation.

157 ength and mucociliary transport but which is dispensable for normal ciliary number, radial structure,

158 tate at CGI-associated gene promoters and is dispensable for normal gene expression.

159 ing leukemia stem cell (LSC) function but is dispensable for normal hematopoiesis.

160 Lastly, we found that CHD4 is dispensable for normal human astrocyte survival.

161 DRL-1 was dispensable for Orsay replication from an endogenous tra

162 domain-containing protein 9 (CARD9) are each dispensable for osteomyelitis induction in Pstpip2(cmo)

163 es that are critical for contacting TPP1 but dispensable for other aspects of telomerase structure or

164 red for ferroptosis upon GPX4 inhibition but dispensable for p53-mediated ferroptosis.

165 of them translated, and found that nine are dispensable for pancreatic endocrine cell development.

166 p97 was dispensable for Parkin ligase activity in iNeurons.

167 to act as a transcriptional repressor but is dispensable for partition.

168 te immune mediators NOD2, MAVS, and TRIF but dispensable for pathways dependent on MyD88 or STING.

169 ent studies have revealed that this motif is dispensable for PC1 trafficking to cilia.

170 In contrast, Gle1 self-association is dispensable for phosphorylation and nonstressed translat

171 ion sites identified and studied to date are dispensable for PKA modulation of LTCC; however, a CaVbe

172 CP regulator Wnt5a, which was, surprisingly, dispensable for planar polarization in the cochlea.

173 We show that the CTD is dispensable for Pol IV catalytic activity and Pol IV ter

174 Taken together, our findings show that CP is dispensable for polarized actin growth and motility in s

175 Thus, integrin function is dispensable for pre-follicle cell polarity but is requir

176 Tumor cell-expressed Angpt2 was dispensable for primary tumor growth, yet in-depth analy

177 conserved among different viral strains, is dispensable for production of infectious HCMV virions in

178 hanisms of RAF and ERK activation make SHOC2 dispensable for proliferation in 2D, KRAS mutant cells p

179 red for optimal NK cell proliferation but is dispensable for protection against ECTV and MCMV, two we

180 und that specific hydroxylated prolines were dispensable for protein stability but required for the a

181 esis experiments show that this extension is dispensable for receptor interactions.IMPORTANCE The MCP

182 We found that eNPCs are dispensable for remyelination but protect partially from

183 ally controls dendritic morphogenesis but is dispensable for repulsive guidance events.

184 CTCF-associated domain boundaries were dispensable for RT.

185 hrough interactions with tumor cells but are dispensable for SCC metastasis.

186 ecessary to form heterochromatic domains yet dispensable for silencing of most transposable elements;

187 e silencing of the foreign gene gfp, but are dispensable for silencing of the endogenous gene oma-1.

188 USP13 was dispensable for sister chromatid cohesion in HCT116 and

189 nd, which is crucial for DNA replication but dispensable for sister chromatid cohesion.

190 we demonstrate that the Hec1 tail domain is dispensable for Ska complex recruitment to kinetochores

191 lytic Integrator subunits, which are largely dispensable for snRNA processing, also have regulatory r

192 activation of oxidative stress responses but dispensable for SpxA2-mediated envelope stress responses

193 Of note, AMPKalpha1 in B cells was dispensable for stability of the bone marrow-resident, l

194 We determined that ldtD is dispensable for stalk elongation; rather, stalk LD-trans

195 l role in T cells, the murine Trx1 system is dispensable for steady-state myeloid-cell hematopoiesis

196 Here, we report that microRNAs (miRNAs) are dispensable for stem-cell self-renewal and neuron produc

197 Furthermore, the TCA cycle is dispensable for survival during osteomyelitis, and S. au

198 dings show that mitochondrial respiration is dispensable for survival of growth plate chondrocytes.

199 The RIM-BP N-terminal domain, while dispensable for SV release site organization, was crucia

200 isitely dependent on xCT expression, xCT was dispensable for T cell proliferation in vivo and for the

201 pansion of differentiated Treg cells but was dispensable for T(H)1/T(H)17 effectors.

202 hus, Tfh induced in classic GC reactions are dispensable for T1D, but the autoimmune process in the N

203 rora B controls KT-MT attachment but appears dispensable for telomere and chromosome arm separation.

204 establish that, by contrast, TRF2 is largely dispensable for telomere protection in mouse pluripotent

205 Consistent with TRF2 being largely dispensable for telomere protection specifically during

206 not systemically delivered allergens but is dispensable for TFH function and IgE production.

207 -regulated PKCs (PKCalpha and PKCdelta) were dispensable for the acquisition of a mesenchymal phenoty

208 ing the complexes at the PM, was found to be dispensable for the association of Gag with the gRNA in

209 he interaction with Eph family receptors are dispensable for the colonization of the B cell compartme

210 early involvement for TNF, IL-1 signaling is dispensable for the development of acute myocarditis.

211 Unexpectedly, KLK7 was dispensable for the development of AD-associated skin in

212 ysine in Ufbp1 that undergoes ufmylation, is dispensable for the development of plasmablasts, but is

213 However, Satb1 is dispensable for the differentiation and non-pathogenic f

214 otho expression in glutamatergic neurons was dispensable for the effects of dietary protein restricti

215 We show that vezatin is dispensable for the formation of synapses but plays a la

216 TOX is largely dispensable for the formation of T(eff) and T(mem) cells

217 l cell differentiation and apoptosis but are dispensable for the formation of the definitive cortex.

218 he highly expressed imprinted lncRNA Meg3 is dispensable for the function of HSCs during homeostasis

219 TCF-1 was dispensable for the generation of specified EILPs, but r

220 y metastatic melanoma, we found that CDK5 is dispensable for the growth of primary tumors.

221 consensus that Th17/IL-17 axis signaling is dispensable for the immunopathogenesis of VVC.

222 Further, IRF-7 expression was dispensable for the induction of a virus-specific CD8 T

223 uggesting that endogenous CD83 expression is dispensable for the inhibitory capacity of Tregs.

224 ic studies revealed that CD18 expression was dispensable for the initial attachment of the bacteria t

225 Forty amino-terminal C protein residues are dispensable for the interaction with P, and the carboxyl

226 activity was required for the former but was dispensable for the latter, indicating that TRAF6-mediat

227 Although dispensable for the pDC development, SphK1 is essential

228 studies, Batf3 expression by CD8 T cells was dispensable for the primary response.

229 Therefore, CaMKIIdelta signaling seems to be dispensable for the progression of VO-induced maladaptiv

230 Here we find that TRF2 is dispensable for the proliferation and survival of mouse

231 s role in development, Hedgehog signaling is dispensable for the proliferative expansion of callus ce

232 Surprisingly, ERRalpha is dispensable for the regulation of its classic targets, s

233 relies on (p)ppGpp, the alarmone molecule is dispensable for the repair of topoisomerase type II (Top

234 g1-mediated protection against arsenic, were dispensable for the response to osmotic stress, and prom

235 e that IL-12, IL-18, and TLRs are completely dispensable for the TCR activation pathway when a strong

236 Conversely, cysLTs are dispensable for the tuft cell response induced by intest

237 We also demonstrate that DNA excision is dispensable for their biogenesis in this ciliate.

238 as error-free, and Pol nu and Pol theta were dispensable for their replicative bypass.

239 retion, and TLR9 activation, but Cagbeta was dispensable for these responses.

240 coagulation, tissue factor, was found to be dispensable for this antimicrobial activity.

241 asophils, but IL-33 and other cytokines were dispensable for this effect.

242 tability by NORAD whereas binding of RBMX is dispensable for this function.

243 y been linked to PrLD phase separation, were dispensable for this recruitment.

244 similar process of protein farnesylation, is dispensable for thymocyte egress but contributes to peri

245 However, ERG is dispensable for TM expression in high SS conditions.

246 these results suggest that primary cilia are dispensable for TonEBP-dependent osmoadaptive response.

247 Additionally, we show that TRAPPC14 is dispensable for TRAPPII complex integrity but mediates R

248 to tumor growth and progression while being dispensable for tumor initiation.

249 G34R/V may become dispensable for tumor maintenance, whereas mutant-PDGFRA

250 iver genes, suggesting that many fusions are dispensable for tumour fitness.

251 al for NMD in simpler organisms appear to be dispensable for vertebrate NMD.

252 Our results reveal that MCU is dispensable for vertebrate photoreceptor function, consi

253 se-like N11 protein is unknown because it is dispensable for viral infection or the release of H18-ps

254 r GAS virulence in WT mice, whereas they are dispensable for virulence in S100a9 (-/-) mice, indicati

255 malian and tick cells, showing this site was dispensable for virus multiplication.

256 in glycolytic mouse muscle, whereas PAK1 is dispensable for whole-body glucose homeostasis and insul

257 PRADC1 is dispensable for whole-body metabolism when mice are fed

258 Thus, protein activities that may be "dispensable" from a topological perspective can neverthe

259 5,000 genes plus a strikingly high number of dispensable genes (20,000) subject to presence-absence v

260 We show that dispensable genes are associated with hemizygous genomic

261 pan-genome architecture is characterized by dispensable genes in accessory genomic regions that exce

262 Dispensable genes usually belong to young and recently e

263 The set of 166 dispensable genes was enriched in olfactory receptor gen

264 c-di-AMP becomes dispensable if the bacteria are cultivated on minimal me

265 We found that immunoproteasome activity is dispensable in adult mice.

266 ixty-two of these 125 genes were found to be dispensable in at least three human populations, suggest

267 ds to habituation deficits and that Hip14 is dispensable in development and instead acts acutely to p

268 ic for long-day adaptation and appears to be dispensable in equinox or DD conditions.

269 siological receptor activation, yet ORAI1 is dispensable in generation of oscillations.

270 Our data show that YAP/TAZ are practically dispensable in hepatocytes for liver development and reg

271 tiating IL-18 secretion in mouse IECs but is dispensable in human IECs.

272 FBXO44/SUV39H1 were dispensable in normal cells.

273 st to previous findings in another study, is dispensable in T. gondii tachyzoites and for T. gondii i

274 endothelial p120, demonstrating that p120 is dispensable in the context of a stabilized cadherin.

275 e expected virulence traits and genes appear dispensable in the replication of S. Typhi, supporting f

276 Whether Cas4-like activity is dispensable in these systems or provided by an unidentif

277 hogenesis in wild-type flies, but it becomes dispensable in Tsf1 mutants due to excessive iron presen

278 e synthetase) was essential in vitro, it was dispensable in vivo.

279 valent H3K4me3 at E6.5 but becomes partially dispensable later.

280 y of APE1, which had been seen as relatively dispensable, may have been preserved during evolution to

281 The 125 dispensable nonolfactory receptor genes also displayed a

282 The 41 dispensable olfactory receptor genes displayed a relaxat

283 l origin mediated by Pten-loss whereas it is dispensable once Pten-loss mediated transformation is es

284 no effect on alpha-SMA levels, suggesting a dispensable role for HA.

285 tion of 786O ccRCC cell line, suggesting the dispensable role of UQCRH in cells that have entered a W

286 he peptidase activities of the receptors are dispensable, suggesting the virus uses/benefits from oth

287 enzymatic activity of ZikV-NS5 appears to be dispensable, the amino acids Y25, K28, and K29 that are

288 ing the dependency, while its bromodomain is dispensable, the DUF3512 domain of BRD9 is essential for

289 ion, our data demonstrate that E-cadherin is dispensable to maintain LC in the epidermis and does not

290 current models, however, mMED and Pol II are dispensable to physically tether regulatory DNA, a topol

291 able, HflX is expressed at low levels and is dispensable under normal growth conditions.

292 mes involved in its synthesis are frequently dispensable under standard culture conditions.

293 BRCA1's downstream role in RAD51 loading is dispensable when 53BP1 is absent.

294 ry acquisition but these programs may become dispensable when a stable memory is formed.

295 in establishment of heterochromatin that is dispensable when full transcriptional silencing is impos

296 ind that this region is largely functionally dispensable when the canonical gammaH2AX-MDC1 pathway is

297 DNA 5mC hypermethylation is dispensable while H3K9 hypermethylation is required for

298 the normal mouse gut, the XusABC system was dispensable, while a xusA mutant colonized poorly during

299 e that CXCR2 signaling in oligodendroglia is dispensable with regard to contributing to neuroinflamma

300 derlying centromeric DNA sequence is largely dispensable, yet paradoxically, it has highly conserved