ライフサイエンスコーパス: disposition

1 10, and did not display target-mediated drug disposition.

2 length of stay, hospital cost, and discharge disposition.

3 d locks the two porphyrins in a face-to-face disposition.

4 erated among individuals with a more anxious disposition.

5 evidence-based practice and a curbed caring disposition.

6 and systemic levels and are involved in drug disposition.

7 other genes involved in drug metabolism and disposition.

8 lity, hospital length of stay, and discharge disposition.

9 at curbs the ad hoc repertoire of the caring disposition.

10 opardized because of erosion of the clinical disposition.

11 bility, ICU and post-ICU healthcare use, and disposition.

12 dependent on both the ring size and exo/endo disposition.

13 ine on metabolic pathways, distribution, and disposition.

14 These results were evaluated with regard to disposition.

15 ological adaptations and unique reproductive disposition.

16 that go above and beyond a general familial disposition.

17 to discharge, median survival, and discharge disposition.

18 ondary outcome measure was adverse discharge disposition.

19 ization costs, length of stay, and discharge disposition.

20 of which were identified after the index ED disposition.

21 h in-hospital, 90-day mortality or discharge disposition.

22 lity, hospital length of stay, and discharge disposition.

23 treat each person according to their unique disposition.

24 rtality, length of stay (LOS), and discharge disposition.

25 re, ICU readmissions, and post-ICU discharge disposition.

26 garding patient admission or early discharge disposition.

27 perception, and illuminate some personality dispositions.

28 length of stay, total charges, and discharge dispositions.

29 rs' behaviour, rather than by their personal dispositions.

30 , 1.12-1.44) and a more favourable discharge disposition (1.46, 1.23-1.72), in a dose-response manner

31 l (RR 1.33, 95% CI 1.12-1.59) and favourable disposition (1.53, 1.19-1.96).

32 safety practices; they all include a caring disposition: (1) a configuration with a dominant caring

33 patients (21%), sporadic MI without familial disposition (10%), and rarely in unrelated real-life cat

34 nsultation (13.6%), and emergency department disposition (11.9%).

35 D-19 at Mount Sinai Hospital with definitive dispositions, 140 patients had telemetric monitoring, an

36 I 1.54-4.73) and a more favourable discharge disposition (3.05, 1.52-6.11).

37 uced mortality (15% vs 26%) and more routine disposition (48% vs 41%) for SL (P < 0.001).

38 germline variants in genes involved in bile disposition: ABCB4 (multidrug resistance 3) rs2302387 an

39 nd parameters, such as severity of symptoms, disposition (admission versus direct discharge), length

40 ristics associated with variation in patient disposition after emergent surgery.

41 ed on potential predictors of CR and patient disposition after pembrolizumab discontinuation after CR

42 tment plan, use of resources, and changes in disposition after performing the ultrasound.

43 This disposition also allows a subgroup of titin domains comp

44 ith improved survival and a better discharge disposition among patients with ischemic stroke.

45 ource use (total hospital cost and discharge disposition among survivors) were analyzed.

46 hospital resource utilization and discharge disposition among survivors.

47 Adjusted odds ratio (aOR) of discharge disposition and adjusted differences in hospital charges

48 Since disposition and biotransformation of GalNAc-conjugated o

49 iples and discuss the consequences for siRNA disposition and biotransformation.

50 any anticancer drugs and plays a role in the disposition and efficacy of several opiates, antidepress

51 key information relevant to the issue is the disposition and fate of the PEG moiety after repeated do

52 IP6K3 is a major determinant of cytoskeletal disposition and function of cerebellar Purkinje cells.

53 stablish a molecular link between amino acid disposition and oxidative stress leading to cytotoxicity

54 t and provide mechanistic insights into drug disposition and patient-specific factors that influence

55 d be expected to affect interindividual drug disposition and response.

56 ondition may lead to large variation in drug disposition and response.

57 f this study was to assess patient discharge disposition and understand CDI-related risk factors for

58 number of acute infections, the HEV genotype disposition and viral phylogeny.

59 re measures of medical researchers' personal dispositions and 10 y of PubMed data indicating their pu

60 adgets but mechanisms shaped both by evolved dispositions and by cultural inputs.

61 re human social ability shaped by biological dispositions and caregiving experiences; yet the mechani

62 ur culture actively transform our behavioral dispositions and mental states by shaping them in variou

63 r the neurobiological underpinnings of these dispositions and the nature (e.g., stability) and adapti

64 Outcomes were mortality, discharge disposition, and 30-day complications.

65 nt, by molecular disposition, by therapeutic disposition, and by physiological effect (e.g., diuretic

66 e investigated differences in LOS, discharge disposition, and charges between hospitalizations for se

67 demographic characteristics, length of stay, disposition, and charges.

68 effect on LOS, 30-day readmission, discharge disposition, and complications.

69 hospital length of stay, patterns of patient disposition, and costs has been incompletely characteriz

70 Donor and recipient risk factors, liver disposition, and discard reasons were analyzed.

71 , hospital type, insurance status, discharge disposition, and ICU drug exposures.

72 ource and type, clinical effects, scenarios, disposition, and length of stay.

73 ortality, perioperative morbidity, discharge disposition, and overall survival.

74 n OATP variants to have differential uptake, disposition, and/or pharmacokinetics of numerous drug su

75 y was to determine if age, diet, and genetic disposition (animal strain) in an animal model had early

76 Hypotheses for how proper-name dispositions are organized within the left ATL include b

77 ten, and chromatin loops transit to a radial disposition around now-central axes.

78 BB penetration were identical, their central disposition (brain levels) and elimination (cerebrospina

79 present products by ingredient, by molecular disposition, by therapeutic disposition, and by physiolo

80 drug lipophilicity or Biopharmaceutical Drug Disposition Classification System class and changes in v

81 els in the synapses of the brain shape human disposition-cognitive flexibility, aggression, depressio

82 The final model featured 2 disposition compartments, saturable clearance, and autoi

83 The final model featured two disposition-compartments, saturable clearance and autoin

84 therapeutic Ab revealed target-mediated drug disposition consistent with a high turnover of endogenou

85 For 5 of 27 (19%) vials, the final disposition could not be confirmed.

86 g; crop protection data; drug metabolism and disposition data and bioactivity data from patents.

87 Among the 1581 patients with ICU disposition data available as of March 25, 2020, 920 pat

88 %] vs 118 of 1338 days [8.8%]; P = .001) and disposition delays (138 of 1168 days [11.8%] vs 97 of 13

89 hours, airway concerns, and somnolence) and disposition delays (end-of-life decisions and floor bed

90 al intensive care unit (SICU) admissions and disposition delays to determine whether targeted interve

91 g to potentially avoidable admissions and/or disposition delays.

92 publications' topical coverage revealed how dispositions differentially predict depth vs. breadth.

93 Sarcopenia predicted adverse discharge disposition (discharge to nursing facility or in-hospita

94 of exposure, dose, symptoms, length of stay, disposition, discharge diagnoses, and attribution of vis

95 three separate domains of sociality (social disposition, dyadic relationships, and social networks)

96 tissues and it plays important roles in drug disposition, efficacy and safety.

97 narrative transportation, and psychological dispositions (egoism and empathy) associated with attrac

98 r pressure (IOP) as well as unfavorable drug disposition exerted by drug transporters before the drug

99 F-isoform activation and secondary organ pre-disposition for metastasis is unknown.

100 ween nursing characteristics and triage call disposition for patient 'same-day' appointment requests

101 Some promoters have a strong disposition for Pol II pausing and often mediate faster,

102 rs and suggests a possible different binding disposition for these complexes in the mismatch site.

103 Humans have dispositions for both retributive and restorative justic

104 s the idea of heteromodal (i.e., transmodal) dispositions for proper naming in the left ATL.

105 up, not attributable to variation in hepatic disposition gene expression.

106 (HR) DNA repair and are germ-line cancer pre-disposition genes that result in a syndrome of hereditar

107 ce that enables comparative analyses of drug-disposition genes.

108 potential influence of polymorphisms in drug disposition genes.

109 sms underlying isomer-specific PFOS and PFOA disposition have not previously been studied.

110 armacokinetic (PBPK) model to predict silver disposition in children.

111 proteins spectrin and adducin whose altered disposition in IP6K3 knock-out mice may mediate phenotyp

112 immuno-PET to directly visualize tissue drug disposition in patients with a noninvasive approach and

113 himpanzees have failed to demonstrate such a disposition in several studies, leading some authors to

114 nia by ultrasound predicts adverse discharge disposition in SICU patients equally well as frailty.

115 r results reinforce the idea that grain-size disposition in subsurface sandy sediments drives the int

116 ed by considerations of in vitro and in vivo disposition in the context of controlled drug release fo

117 a new opportunity to gain knowledge on drug disposition in the intensive care.

118 y is now available to gain knowledge on drug disposition in the intensive care.

119 s of the FVIII C domains compared with their disposition in the unbound state.

120 ments for metabolites best describe morphine disposition in this population.

121 he activity of the major human P450s in drug disposition in vivo.

122 nded for follow-up within the practice (call disposition), including all contact types (face-to-face,

123 erged as potential mediators of chemotherapy disposition, including drugs such as methotrexate, doxor

124 The primary physiological outcome was disposition index (a measure of beta-cell function) at 1

125 efflux/apoA-I presented significantly higher disposition index (beta = 0.056, SE = 0.026; p = 0.035).

126 47 case vs. 12,645 control subjects), higher disposition index (beta = 0.07 log10; P = 2 x 10(-11); n

127 l function, evidenced by a faster decline in disposition index (DI) and a lower DI at age 18 years.

128 The primary endpoint was change in the disposition index (DI).

129 lin sensitivity (SI) and beta-cell function [disposition index (DI)].

130 ce -0.45 [95% CI -1.34 to 0.44], p=0.319) or disposition index (mean difference -940 [95% CI -5655 to

131 -0.45; 95% CI, -1.34 to 0.44; P = 0.319), or disposition index (mean difference, -940; 95% CI, -5655

132 at betatrophin was negatively related to the disposition index (rho = -0.53, p = 0.014).

133 beta-cell function relative to ATIS (adipose disposition index [DI]) in obese youth with impaired glu

134 In the intention-to-treat population, disposition index increased in both groups (between-grou

135 nt with an effect on beta-cell function, the disposition index relating the amount of insulin secrete

136 Disposition index was estimated as beta-cell function in

137 which improved only after RYGB, and improved disposition index were associated with lower HbA1c in bo

138 n of arginine-induced insulin secretion, and disposition index were characterized by glucose-potentia

139 ulin secretion, insulin sensitivity, Ra, and disposition index were measured after oral glucose toler

140 ociated with decreases in insulin secretion (disposition index) and the elevation of fasting or 2-h g

141 an twofold improvement in glucose tolerance (disposition index).

142 insulin sensitivity, and beta-cell function (disposition index, DI(h-clamp)).

143 n insulin secretion, insulin sensitivity and disposition index.

144 insulin secretion, insulin sensitivity, and disposition index.

145 lucose effectiveness/T2D, 11p15 (KCNQ1) with disposition index/T2D, and 6p22 (CDKAL1) and 11q14 (MTNR

146 Insulin secretion/insulin resistance (disposition) index declined by 60% (second clamp step) a

147 h the insulin secretion/insulin sensitivity (disposition) index increased significantly in IFG, but n

148 s new insights into how scientists' personal dispositions influence research processes and products.

149 Renal potassium disposition is primarily handled by a short segment of t

150 we investigated whether this hyperaltruistic disposition is susceptible to monoaminergic control.

151 tructions to Authors for Drug Metabolism and Disposition, Journal of Pharmacology and Experimental Th

152 with a two-compartment model and tumor drug disposition kinetics were modeled with first-order influ

153 thologies, it remains unclear how individual dispositions may interact with situational incentives to

154 ome plays a clinically relevant role in drug disposition, mechanistic insights, and translational app

155 escribed successfully by a three-compartment disposition model with flexible absorption.

156 This mode of disposition neither altered the morphology/integrity of

157 ossibly other transporters influence in vivo disposition of (11)C-erlotinib and thereby affect its di

158 e disposition of chiral PCBs, we studied the disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 13

159 assess the impact of ABCC1 on the pulmonary disposition of 6-bromo-7-(11)C-methylpurine ((11)C-BMP),

160 inary translational data regarding the brain disposition of [(11)C]-(R)-3 in primates including first

161 tions that take place in the more stable syn-disposition of [4.12].

162 ysiological importance in the absorption and disposition of a range of solutes, eight SLC22A family m

163 drug transporters involved in the uptake and disposition of a wide array of structurally divergent en

164 n structures introduce irregularities in the disposition of adjacent residues that facilitate the spe

165 and toxicological studies on the effects and disposition of aldehydes.

166 d space in varied ways they all identify the disposition of ancestral folds to fall within this core

167 d by taxon differences and by the amount and disposition of archipelago area.

168 hysiologically based TK model describing the disposition of BPA and BPS and their glucuronides was bu

169 system is responsible for the metabolism and disposition of chemopreventive agents, chemical toxins a

170 of hepatic vs extrahepatic metabolism in the disposition of chiral PCBs, we studied the disposition o

171 l properties and in vivo oral absorption and disposition of cordycepin were assessed in rats.

172 approach seeks to mimic the orientation and disposition of critical binding residues at protein inte

173 ter ECMO and mortality in those with a final disposition of death or discharge were less than 40%.

174 as 39% (380 of 968) in patients with a final disposition of death or hospital discharge.

175 rting polypeptide (OATP) transporters to the disposition of doxorubicin.

176 OATP1A/1B in transporter-mediated uptake and disposition of doxorubicin.

177 Signs, symptoms, diagnosis, and disposition of employees with eye complaints as well as

178 gate and analog transporter that affects the disposition of endogenous metabolites, toxins, and drugs

179 btain a universal expression for the average disposition of energy of transmission eigenchannels with

180 drug-circuit interactions and determine the disposition of five commonly used antimicrobials (merope

181 amework as applied to disputes regarding the disposition of genetic material between the oncofertilit

182 rrent scholarship tangentially discusses the disposition of genetic material in regards to pediatric

183 lemetric ECG monitoring and had a definitive disposition of hospital discharge or death.

184 arrier, where it may influence the pulmonary disposition of inhaled drugs and contribute to variabili

185 Indeed, the overall stereochemical disposition of its ring fusions is distinct from those o

186 esults provide a better understanding of the disposition of morphine and its metabolites in criticall

187 ortant clearance mechanisms that mediate the disposition of my molecule?

188 wo-photon fluorescence imaging, to probe the disposition of nanoparticles and an associated lipophili

189 We explore how the caring disposition of nurse middle managers' habitus influences

190 nd safety of bedside and research personnel, disposition of patients already enrolled in nonpandemic

191 are consultations, and (5) encouraging early disposition of patients to floor beds.

192 t and isolation purposes and for appropriate disposition of patients with false-positive CT findings.

193 heostomy complications, inpatient mortality, disposition of patients, and transmission of COVID-19 to

194 hrome P450 (P450) enzymes play a role in the disposition of PCBs.

195 inhibitory antibodies informs on the natural disposition of Pfs25 on the surface of ookinetes and pro

196 nuclear pore complexes, we demonstrate that disposition of polyethylenimine (PEI)/DNA polyplexes tha

197 Given the error-prone disposition of PrimPol, we propose a mechanism whereby S

198 ntally incompatible with the circumferential disposition of sclerites in early molluscs, but does clo

199 ties linked to potent activity, requires the disposition of siRNA to be characterized.

200 ver, the effect of Gilbert's syndrome on the disposition of some drugs can lead to unexpected toxicit

201 re to ethanol has been reported to alter the disposition of tangentially migrating GABAergic cortical

202 iation of insurance status and race with the disposition of TBI patients evaluated in less specialize

203 The influence of nonmedical factors on the disposition of TBI patients initially seen in less speci

204 The disposition of tenofovir diphosphate (TFV-DP) and emtric

205 Brain penetration, target engagement, and disposition of the blood-brain barrier-crossing bispecif

206 d of three, so large changes in the relative disposition of the C2-domains result from changing the l

207 A pharmacokinetic model of intake and disposition of the chemicals predicted their internal co

208 ns, based on the shape of the somata and the disposition of the dendrites.

209 the amino acids changes the relative spatial disposition of the DNA-binding domains and thereby disru

210 ium kinetic isotope effect on the safety and disposition of the drug substance.

211 portant insight into the impact of pH on the disposition of the key Fe-O-O and Fe horizontal lineO fr

212 ular ruler and template, but the exact axial disposition of the molecule has not been determined.

213 Finally, our analysis reveals the disposition of the N-terminal segment of Msm sigma(A), w

214 are differentiated by "inward" and "outward" disposition of the pyran-2-one moiety have been synthesi

215 chiral induction revealed that the geometric disposition of the quinoline ring at the C8 chiral carbo

216 eries of compounds and the cause of a unique disposition of the thioxo group at close-to-right angles

217 between vT3SSs and fT3SSs, such as relative disposition of their inner membrane-attached export plat

218 rinciples that govern brain distribution and disposition of these antibodies.

219 The disposition of toxicants is often affected by their bind

220 t extrinsic cationic proteins, can alter the disposition of transmembrane proteins and causes the loc

221 Nurse characteristics were associated with disposition of triage calls to within practice follow-up

222 The relative disposition of VPS29s in hetero-hexameric, membrane-atta

223 mented the normative beliefs and cooperative dispositions of 759 individuals spanning nine clans nest

224 has demonstrated that concepts of Bourdieu (dispositions of habitus, capital and field) help to desc

225 in were used to define the three-dimensional dispositions of individual amino acids that are subject

226 services use, and vital status and discharge dispositions of patients with polymerase chain reaction-

227 and controlling the relative conformational dispositions of redox-active units in macrocycles are ke

228 omparison enables us to explain the specific dispositions of subknots in the analyzed protein knots.

229 It revealed various configurations of dispositions of the habitus in which a caring dispositio

230 We observed three distinct configurations of dispositions of the habitus which influenced the clinica

231 The dispositions of the nurse middle managers' habitus influ

232 of the NPNA beta-turns results in different dispositions of the subsequent NPNA and, hence, differen

233 ic derivatives with different conformational dispositions of their PMDI units and the acyclic PMDI de

234 Although the dispositions of tyrosines differ in different constructs

235 o direct the molecular-level arrangement (or disposition) of the tectons.

236 Thus, individual dispositions or traits may be determined by neural proce

237 gnificant difference in mortality, discharge disposition, or transfer to ICU, although there was a re

238 3.22; 95% CI, 2.94 to 3.53), and a discharge disposition other than home (OR, 3.64; 95% CI, 3.46 to 3

239 length of stay, daily charges, and discharge disposition other than to home.

240 prior to hospitalization and likely does in disposition outcomes.

241 ), ICU mortality (p = 0.55), and ICU patient disposition (p = 0.22) were similar in the two groups.

242 better than 10% in the determination of drug disposition parameters.

243 Here, we examine how vemurafenib disposition, particularly through cytochrome P450-mediat

244 ork, we have studied the oral absorption and disposition pathways of cordycepin, an adenosine analogu

245 ng transporter information to explain tissue disposition patterns of PrEP drugs, to interpret inter-i

246 were demographic characteristics, discharge disposition, payer, and cost data.

247 hospitalization after injury is vital in the disposition planning for these patients.

248 es, environmental influences, or personality dispositions play?

249 ispositions of the habitus in which a caring disposition plays a crucial role.

250 position and physiology that can affect drug disposition, possibly leading to therapeutic failure or

251 is the first comprehensive evaluation of the disposition profile for a protein therapy in the cochlea

252 These compounds also have good disposition properties and show no adverse toxicologic e

253 hanistic understanding of the candidate drug disposition properties before nomination to clinical dev

254 However, 1 suffers from suboptimal drug disposition properties resulting in a short half-life (t

255 ination to enhance activity and improve drug disposition properties.

256 Analyses of causes of death and busulfan disposition provided no mechanistic explanation for the

257 ation coupled with a measure of central drug disposition provides evidence that this molecule engages

258 which likely indexed variations in internal dispositions related to fatigue or satiety.

259 Iscalimab exhibited target-mediated drug disposition resulting in dose-dependent and nonlinear ph

260 atotoxicity through derangement of bile acid disposition; results also suggest that pharmacogenomic m

261 Treatment and patient disposition should be tailored to the severity of clinic

262 ) a configuration with a dominant scientific disposition showing an investigative, non-judging, analy

263 tic membrane transporter expression and drug disposition similarly in humans and rodent models of NAS

264 In vivo doxorubicin disposition studies revealed that doxorubicin plasma are

265 ies, above and beyond fostering person-level dispositions such as self-esteem.

266 Some familial pre-disposition suggests a germ-line contribution to CMN syn

267 t new sites (16.8% of readmissions), 25 with disposition support issues (14.5%), 23 with infections n

268 atite formed at >1000 degrees C has a glassy disposition that prevents its water-based leaching; and

269 : (1) a configuration with a dominant caring disposition that was helpful (via solving urgent matters

270 with an interaction of caring and collegial dispositions that led to an absence of clinical involvem

271 haviour based on the clinical and scientific dispositions that was manifested through an investigativ

272 cal studies suggesting roles in chemotherapy disposition, the pharmacogenetics of OATPs in cancer the

273 changes in the gut microbiome can alter drug disposition, the pharmacokinetics (PK), and biodistribut

274 son is well established as an inherent human disposition through which humans navigate the social wor

275 ont of the eye designed to somehow alter its disposition to bring about changes in focus.

276 that halogenases control substrate-cofactor disposition to disfavor oxygen rebound and permit haloge

277 ability but not by shared socialization, the disposition to distrust is explained by shared socializa

278 the sources of individual differences in the disposition to distrust, including how they may differ f

279 ical outcomes, length of stay, and discharge disposition to home.

280 central coherence account posits an altered disposition to integrate features into a coherent whole

281 are left with major questions about how the disposition to think analytically can evolve.

282 Our results demonstrate that although the disposition to trust is explained to some extent by heri

283 the sources of individual differences in the disposition to trust.

284 roma burden, its metabolic activity, and the disposition to vascular thrombosis building a platform f

285 Dispositions to control, approach, escape, and avoid one

286 d a main effect of MAOA genotype on having a disposition toward violence in both samples and for viol

287 , charges per day, length of stay, discharge disposition, tracheostomy, and need for extracorporeal m

288 Deceased donor kidney disposition was determined from small pediatric donors w

289 Ranibizumab disposition was determined in RVO and DME patients and c

290 s in Houston, Texas, admission and discharge disposition was obtained for patients with CDI and match

291 These changes in disposition were caused by ob/ob- and MCD diet-specific

292 length of stay, complications, and discharge disposition were collected.

293 nomic index, insurance status, and discharge disposition were not associated with RBANS scores.

294 od, where interesting features of mAb tissue disposition were observed.

295 dic phospholipids induces structure, but its disposition when bound to lipid bilayers is controversia

296 of the metal and provide donor atom types or dispositions which favour the formation of particularly

297 A dominance of the caring disposition, which meant 'always' answering calls for he

298 if V to twist and order in the SaPI-inducing disposition, while the tip of motif VI is disturbed.

299 requires a better understanding of the drug disposition within a cell.

300 ng hypotheses about how scientists' personal dispositions would uniquely predict deeper vs. broader c