ライフサイエンスコーパス: disrupt

1 membrane morphology and lipid packing became disrupted.

2 n when the canonical TIR1 auxin signaling is disrupted.

3 n of the FOS transcription factor complex is disrupted.

4 ) or lecithin-retinol acyltransferase (LRAT) disrupt 11-cis-retinal synthesis and cause Leber congeni

5 These results demonstrate that disrupting 32-38 and anticodon sequences alters interact

6 we employed a CRISPR/Cas9-based approach to disrupt a subset of cytokinin histidine kinase (HK) rece

7 arian tumor progression based on selectively disrupting a previously unappreciated signaling cascade.

8 We show that disrupting a top candidate from the screens, the mitocho

9 Ser/Thr phosphorylation, whilst FGF4-ERK1/2 disrupts a core pluripotency transcriptional circuit req

10 n recovery of a crwn4-2 missense allele that disrupts a predicted NLS and lowers the abundance of CRW

11 , present at nearly 100% heteroplasmy, which disrupts a Watson-Crick base pair in the T-stem-loop.

12 We find that SCF-FBXL17 disrupts aberrant BTB dimers that fail to stabilize an i

13 otubule-disrupting tumour-selective vascular disrupting agent (VDA).

14 fetal origin of asthma is orchestrated by a disrupted airway epithelium and further perpetuated by a

15 roteomics with a library of nucleosomes that disrupts all exposed histone surfaces to comprehensively

16 epeats (CRISPR)-Cas9 system and a transposon-disrupted allele.

17 ate, the untoward phenotypic consequences of disrupting allelic and non-allelic (e.g. pseudogene) seq

18 e for these recurrent noncoding mutations in disrupting an autoregulatory feedback mechanism, thereby

19 a luciferase reporter system, mutagenesis to disrupt and restore base pairing revealed that the MTE i

20 es with the LDH tetramerization domain, thus disrupting and destabilizing LDH tetramers.

21 ts lacking the set of immunoevasins known to disrupt antigen presentation via MHC class I.

22 CD8 T cell recognition of infected cells by disrupting antigen presentation pathways.

23 levels in cells, and this can be rescued by disrupting APC-mediated actin nucleation.

24 t both the cellular and functional level and disrupted astrocyte-endothelial interactions in both ani

25 ring a broken-symmetry striped phase that is disrupted at both high and low extremes of chemical pote

26 GluR-mediated long-term depression (LTD) was disrupted at these timepoints.

27 RE impairs Mitf/TFEB nuclear import, thereby disrupting autophagy and exacerbating proteostasis defec

28 ol, the psychoactive ingredient of cannabis, disrupts autophagy selectively in the striatum, a brain

29 Disrupting bacterial adherence to the intestinal surface

30 us human BAF complex, identifying those that disrupt BAF subunit-subunit and subunit-nucleosome inter

31 AgrC-I, while analogs designed to contain a disrupted beta-turn were dramatically less potent relati

32 hich become buried at the complex interface, disrupt binding of hIL-23p19 to hIL-23R.

33 lammation; all occur within the context of a disrupted bone marrow microenvironment.

34 substitution of the N-terminal plug His-221 disrupts both signaling and transport, leading to dysreg

35 Furthermore, phosphorylation of AGO2(Y393) disrupts both the wild-type and oncogenic KRAS-AGO2 inte

36 recipients in whom tolerance maintenance is disrupted by an episode of acute CMV infection.

37 ibution of pulmonary perfusion, which may be disrupted by cardiopulmonary disease, but this is not we

38 interaction of N-MADD-4B with NLG-1 is also disrupted by heparin, used as a surrogate for the extrac

39 habditis elegans muscle, but this pattern is disrupted by mutations in the mitochondrial fission comp

40 iological actions by 1,25(OH)(2)D, which are disrupted by mutations in the VDR.

41 re an intact optic nerve, its fine-tuning is disrupted by ONS.

42 This process was disrupted by small interfering RNA (siRNA)-based down-re

43 Once formed, messicles are not disrupted by subsequent changes in P:L ratio.

44 ne, SHANK2, located on Chromosome 11q13, was disrupted by SVs in 14% of MYCN nonamplified high-risk t

45 b downstream of TAL1 and this interaction is disrupted by the -31CBS inversion in T-ALL cells.

46 Phosphorylation of Ser(16) was disrupted by the cardiomyopathy-associated DeltaArg(14)

47 tered when early and recycling endosomes are disrupted by the expression of dominant-negative mutants

48 IL-10 and IFN-gamma signaling were disrupted by using blocking antibodies.

49 ong with decreased myocyte contractility and disrupted Ca(2+) cycling.

50 dues (949)Arg-Arg-Lys(951) to three alanines disrupts CaMKII binding in vitro and CaMKII association

51 facilities facing higher costs might close, disrupting care delivery and access to care.

52 l to the development of new antibiotics that disrupt cell wall biogenesis, a process essential to the

53 QKI-7 upregulation is correlated with disrupted cell barrier, compromised angiogenesis and enh

54 (the majority) and brain-specific risk genes disrupts cell proliferation, neurogenesis, migration, an

55 Early exposure to such endocrine disrupting chemicals (EDC) may affect brain development

56 The presence and distribution of endocrine-disrupting chemicals (EDCs) in the mariculture fish from

57 ndocrine system are referred to as endocrine-disrupting chemicals (EDCs).

58 Endocrine disrupting chemicals are common in our environment and a

59 and risk assessment of these thyroid hormone disrupting chemicals.

60 sing role for Cds1 in driving DNA damage and disrupted chromosomal segregation under certain conditio

61 Acoustic trauma disrupts cochlear blood flow and damages sensory hair ce

62 ing in neurons can worsen disease course and disrupt complex interactions between the IFN-alpha/beta

63 We investigated the normal and disrupted development of microglia in barrel cortex by c

64 cross-linking under reducing conditions that disrupt disulfide bridges, but soluble fibronectin did n

65 rmine the pathway by which these metabolites disrupt DNA repair.

66 Furthermore, shRNA COASY knockdown disrupted downstream PI3K pathway activation and also hi

67 molecular mechanisms of action of 3D genome-disrupting drugs.

68 Disrupting each cluster selectively impairs native Ded1

69 f individual microRNA-target interactions by disrupting each predicted miRNA-binding site by CRISPR-C

70 is sequence-specific DNA-binding protein can disrupt EBV latency by driving the transcription of targ

71 trols, mice that had their circadian rhythms disrupted (ECD) had higher Chlamydia loads, more tissue

72 Infiltration of activated PECs may disrupt ECM remodeling in cFSGS.

73 single incorporated zebularine also did not disrupt editing in vitro, suggesting that PPR65 cannot b

74 This was associated to the disrupting effect that the microwaves had on BSG fiber,

75 le, with reports of strategies that directly disrupt either the RAS interaction with activating guani

76 ferent proteins that localize to the SF base disrupts either SF steady-state length or ciliary force-

77 nt 83 double mutant combinations reported to disrupt embryo development; emphasize the importance of

78 nce-modifying enzyme such as Cas9/gRNAs that disrupts endogenous versions of an essential gene and a

79 interactions, inhibited tube stability, and disrupted endothelial cell junctions.

80 patients, such as increased inflammation and disrupted energy-regulating neuroendocrine signaling (e.

81 lyoxal caging can also be used to reversibly disrupt enzyme-nucleic acid interactions, and we show th

82 report in Science that type III IFNs disrupt epithelial cell proliferation and differentiatio

83 rvicovaginal fluid (CVF) from women with BV, disrupted epithelial polarization.

84 tructures of the arteries were significantly disrupted, especially the tunica media, following incuba

85 or unilateral E2 synthesis inhibition in NCM disrupted eventual song imitation.

86 e formation of sharp Purkinje cell zones and disrupts excitatory axon patterning.

87 on through modulating F-actin, while mutants disrupting F-actin binding are defective in its tumorige

88 ardiomyocyte proliferation and maturation by disrupting fibronectin-integrin signaling, consistent wi

89 r markers, and that LSD1 inhibition globally disrupts FOXA1 chromatin binding.

90 Mutating region V severely disrupted function without affecting subcellular localiz

91 Notably, these alterations arise from disrupted functional interactions of mGluR5 with estroge

92 could reduce synchrony both within species (disrupting gene flow among subpopulations) and among spe

93 nsure faithful genetic inheritance, SMCs can disrupt genome stability by trapping DNA topological str

94 ace-like stimuli were presented upside-down, disrupting global processing (Experiment 4).

95 rotein synthesis and degradation is found to disrupt glutamatergic transmission and excitability in n

96 though we found little evidence that suramin disrupts glycolytic or glycosomal pathways, we noted inc

97 Lack of ERalpha in GHRH neurons disrupts growth in both sexes and causes pubertal delay

98 teronyssinus allergens in breast milk, which disrupt gut immune homeostasis and prevents oral toleran

99 cer at H-NS-repressed quorum sensing loci by disrupting H-NS nucleoprotein complexes that block trans

100 air-bundle regulators and late Six1 deletion disrupts hair-bundle polarity.

101 ressing the Epe1 C-terminus is sufficient to disrupt heterochromatin by outcompeting the histone deac

102 idelines can be inadequate and contribute to disrupted homeostasis, lean body mass loss, and deterior

103 te nutrient intake leads to oxidative stress disrupting homeostasis, activating signaling, and alteri

104 rminal Src homology and Bcr homology domains disrupts homodimer formation and impacts PI3K signalling

105 Here, we show that inhibition of PARG disrupts homology-directed repair (HDR) mechanisms that

106 Dengue virus (DENV) infection disrupts host innate immune signaling at various checkpo

107 cine-95 (and to a lesser extent, glycine-91) disrupted IFITM3 oligomerization and reduced its antivir

108 a major output of STING signaling; however, disrupting IFN signaling during L. monocytogenes-induced

109 EMENT Spinal cord injury (SCI) significantly disrupts immunity, thus increasing susceptibility to inf

110 e individual's response to threat and may be disrupted in anxiety and post-trauma psychopathology.

111 ain emotional equilibrium, a process that is disrupted in depression.

112 residues, and this membrane sequestration is disrupted in EHEC that expresses constitutively active G

113 scribe the key chromatin regulatory pathways disrupted in gliomas, delineating their physiological fu

114 tissue development, and homeostasis, and are disrupted in human cancers.

115 on calcium activity of dorsomedial iMSNs was disrupted in mice lacking D2Rs on iMSNs, suggesting that

116 cally with the actomyosin network, which was disrupted in patient cells, causing impaired nucleokines

117 ental illness-related susceptibility factor, Disrupted in schizophrenia (DISC1), is involved in host

118 ings indicated that BDNF/TrkB signalling was disrupted in the OC of Nhe6 KO mice, probably due to Trk

119 Overall, nodules disrupted in the symbiosis were elevated in metabolites

120 trols, mice that had their circadian rhythms disrupted in this ECD model will have a higher Chlamydia

121 ce in all three areas that MD preferentially disrupts in V1, but not in LM or PM.

122 e outer mouth of the selectivity filter (SF) disrupts inactivation and K(+)-selective transport in hE

123 ad the design of canonical vaccines aimed at disrupting infection in the host.

124 ral modifications to cladding materials that disrupt insect vision could reduce the incidence of D. s

125 localized thermal managing strategy, thermal-disrupting interface induced mitigation (TRIM), is repor

126 f metabolism are genetic conditions that can disrupt intermediary metabolic pathways and cause defect

127 low among subpopulations) and among species (disrupting interspecific interactions in communities).

128 ed that the MBD binds to iron and that azide disrupts iron binding.

129 triatal connectivity in TRD participants but disrupted it in HVs independently of inflammatory proces

130 oduction of a germline mutation at Bahcc1 to disrupt its H3K27me3 engagement causes partial postnatal

131 Phosphomimetics of HDA15 partially disrupt its oligomerization and cause loss of enzymatic

132 eukemia (AML) mutation, Arg882His, in DNMT3A disrupts its cooperative mechanism and leads to reduced

133 3a(K14Delta/Delta) mice have increased TEWL, disrupted junctional proteins, and increased susceptibil

134 Therefore, disrupting K-Ras PM interaction is a tractable approach

135 enhances proliferation of keratinocytes and disrupts keratinocyte differentiation.

136 Loss of SAM or Sugt1 both disrupts kinetochore assembly in mitotic cells due to th

137 ing with dominant negative connexin 43 or by disrupting lactate efflux was sufficient to mimic the ef

138 Overall, our study demonstrates that disrupting LDH oligomerization state by targeting their

139 enzyme fructose 1,6-bisphosphatase 1 (FBP1) disrupts liver metabolic homeostasis and promotes tumour

140 nalysis indicates that the R330fs mutant can disrupt localization of ER-alpha and FOXA1.

141 lected for the ability to partition into and disrupt membrane integrity but with no known antiviral a

142 ctivity and extend channel lifetimes without disrupting membrane integrity, in a manner consistent wi

143 ut not dorsal hippocampus (CA1), selectively disrupts memories associated with methamphetamine (METH)

144 t neural and cognitive stress mechanisms may disrupt memory retrieval and restrict prospective planni

145 stemic circulation of bile acids can greatly disrupt metabolic homeostasis.

146 d regulatory Fe-S centers of proteins by LCO disrupts metabolic homeostasis, which negatively impacts

147 Here we show that tumour cells disrupt methionine metabolism in CD8(+) T cells, thereby

148 increase vulnerability of genes in sperm to disrupted methylation.

149 In other words, sulfide likely disrupted microbial cross-feeding between AOB and NOB an

150 of barrier crossings in prevailing winds can disrupt migratory routes towards slightly different goal

151 Here, we disrupt minor spliceosome function in the developing mou

152 nt selection pressure against mutations that disrupt miRNA binding.

153 ling in diabetic kidneys, a cardinal sign of disrupted mitochondrial architecture and bioenergetics.

154 ry and motor circuits.SIGNIFICANCE STATEMENT Disrupted mitochondrial transport has been linked to neu

155 We found that disrupting mitochondrial fission (DRP1/drp-1) or fusion

156 Gene perturbations disrupt morphogenesis and histo-differentiation.

157 Lack of SMGs and mucus strands disrupted mucociliary transport in EDA-KO pigs.

158 he INR phenotype is caused by a persistently disrupted mucosal barrier, but assessments of gut mucosa

159 "clean" Chinese hamster ovary (CHO) cell by disrupting multiple genes to eliminate HCPs.

160 Disorders that disrupt myelin formation during development or in adulth

161 Strategies to restore disrupted myocardial calcitonin signalling thus may offe

162 thogenesis; however, the mechanisms by which disrupted NCT causes neurodegeneration remain unclear.

163 viral genes by degrading ND10 organizers to disrupt ND10.

164 Perilesional sleep-like off-periods can disrupt network activity but are potentially reversible,

165 DC) may affect brain development by directly disrupting neural programming and/or through the microbi

166 ther set (the majority being brain specific) disrupts neurite outgrowth, synaptogenesis, and the 'wir

167 they form lipid-stabilized pores that might disrupt neuronal membranes and ion homeostasis.

168 expression of fusogens in the nervous system disrupts neuronal individuality, which, in turn, leads t

169 y, mice in which both Nf1 and Rac1 loci were disrupted (Nf1(flox/flox)Rac1(flox/flox);PostnCre (+)) w

170 y, mice in which both Nf1 and Rac1 loci were disrupted (Nf1(flox/flox)Rac1(flox/flox);PostnCre(+)) we

171 ransiently suppressed USV production without disrupting non-vocal social behavior.

172 cancer-associated perturbations collectively disrupt normal gene regulatory networks (GRNs) by increa

173 a knockout of a predicted upstream regulator disrupts normal regeneration, validating our prediction.

174 Disrupted nucleocytoplasmic transport (NCT) has been imp

175 d coral bleaching and to invasive rats which disrupt nutrient subsidies from native seabirds.

176 of the transcription factor Gli3 is known to disrupt olfactory development, however, if Gli3 plays a

177 c function to inhibiting caspase cleavage to disrupting oligomerization and pore formation.

178 IRE1 kinase inhibitors either allosterically disrupt or stabilize the active dimeric unit, accordingl

179 onoxide) can reduce sugar accumulation, thus disrupting or delaying the recovery process.

180 onstrate that the prevention of gene pairing disrupts oscillations and segmentation, and the linkage

181 mice lacking D2Rs on iMSNs, suggesting that disrupted output of iMSNs contributes to heightened avoi

182 They also displayed disrupted patterns of paired box 2a (pax2a) and SRY-box

183 Inhibition of VTA-core-projecting neurons disrupted Pavlovian reward learning, and activation of t

184 ble version of a protein phosphatase-1 (PP1)-disrupting peptide (PDP-Nal) that triggers protein phosp

185 us minor coat protein VI contains a membrane-disrupting peptide that is inactive when VI is bound to

186 in patients with myasthenia gravis, although disrupted peripheral tolerance may play a greater role i

187 e key points of vulnerability for therapy to disrupt peritoneal spread and adhesion of ovarian cancer

188 ed States (BX-R) also harbors mutations that disrupt PgABCA2.

189 We conclude that recessive mutations disrupting PgABCA2 are the primary, but not the only, me

190 effectors, YopE and YopT, inactivate RhoA to disrupt phagocytic signaling.

191 n the C terminus that are linked to deafness disrupt phospholipid binding, sensitize the channel to P

192 Obesity disrupts physiological homeostasis and alters both syste

193 lly regulated cell invasiveness, in part, by disrupting polarized cell motility under confinement and

194 e, and sensitive assessment of the endocrine-disrupting potential of benchmark chemicals based on dat

195 BAergic transmission onto pyramidal neurons, disrupt prefrontal excitatory-inhibitory balance, and al

196 activity align with the relationship between disrupted prefrontal function and cognitive rigidity in

197 ability to detect environmental conditions, disrupting previous correlations between parental and of

198 sion to impaired information sampling and to disrupted probabilistic reasoning, namely to overweighti

199 we discover that genetic deletion of Gravin disrupts proper accumulation and asymmetric distribution

200 ite specificity in lysates and live cells to disrupt protein function.

201 ls (NSCs) utilize aggresomes to recover from disrupted proteostasis and describe a novel function for

202 ion in the class Ib MHC molecule Qa-1, which disrupts Qa-1 binding to the T cell receptor (TCR)-CD8 c

203 etamine, creating a hyperdopaminergic state, disrupted rats' ability to discriminate between cues ass

204 ction of griseofulvin in adult mice does not disrupt retinal vasculature, function, or morphology.

205 tion in the cell body, the precise impact of disrupting retrograde transport on the organelles and th

206 hemogenetic silencing of lateral OFC neurons disrupted reversal learning, as well as plasticity in S1

207 lative abundance and identified 13 taxa with disrupted rhythmicity in type 2 diabetes (T2D).

208 ns dcl2, dcl3 and dcl4 to the msh1 rootstock disrupts siRNA production and reveals RdDM targets of me

209 g accumulation of lipid metabolites known to disrupt skeletal muscle insulin signalling in sedentary

210 ther demand, in the form of cognitive tasks, disrupted sleep and the cortisol awakening response (CAR

211 ealth and the prevalence of insufficient and disrupted sleep.

212 dation, alters gene expression patterns, and disrupts spine morphology.

213 AT3-dependent transcriptional activation and disrupts STAT3 interaction with the IL-22 receptor.

214 aptotagmin-1 to PIP(2)-containing nanodiscs, disrupting synaptotagmin-1-SNARE interactions.

215 nserved in each LIM domain of these proteins disrupt tensed F-actin binding in vitro and cytoskeletal

216 Prostaglandin E2 (PGE2) disrupts TGFbeta signaling and suppresses myofibroblast

217 We disrupted Tgr5 specifically in Lgr5-positive ISCs in mic

218 d K400A (SH2 position betaD6) is required to disrupt the binding.

219 We then use genome editing to disrupt the coding sequence of a S. rosetta C-type lecti

220 for the end of the 21st century, could thus disrupt the community structure and productivity of a cr

221 Such changes to the environment can disrupt the connection between habitat quality and the c

222 several distinct shifts in brain state that disrupt the contents of consciousness distinct from arou

223 These compounds, including one proposed to disrupt the dimer, slow the rate of substrate processing

224 hat mutations found in individuals with MCHS disrupt the DNA-binding function of MEF2C, and DNA bindi

225 tic and polar-protic solvent combinations to disrupt the H-bonds and hydrophobic interactions holding

226 Increased levels of periodontal pathogens disrupt the homeostasis between the host and its microbi

227 body sequences, we developed nanobodies that disrupt the interaction between Spike and ACE2.

228 on by RAS and to develop inhibitors that can disrupt the KRAS dimerization.

229 a indicate that non-coding somatic mutations disrupt the PAX8 transcriptional network during OC devel

230 Employing CRISPR/Cas9 gene editing to disrupt the Pdgfra gene in two different murine cell lin

231 at the administered pain medication does not disrupt the physiological mechanisms that are beneficial

232 tional disconnection approach to temporarily disrupt the PL-RMTg pathway during cue- or cocaine-induc

233 t-Marie-Tooth disease-causing mutations that disrupt the stability of PMP22 tertiary structure reduce

234 is sufficient to redirect axon targeting and disrupt the topographic map.

235 This hyperactivity disrupted the balance between excitation and inhibition

236 nformation and that prior cocaine experience disrupted the evolution of representations both within t

237 Using CRISPR-Cas9, we disrupted the expression of ZFP628 in the mouse and unco

238 We disrupted the Fas-associated factor 1 gene (FAF1) in DLD

239 died pigs, which have lungs like humans, and disrupted the gene for ectodysplasin (EDA-KO), which ini

240 Specifically, sucrose supplementation disrupted the homeostasis between acid-producing and alk

241 ell compartment in mice, where loss of VISTA disrupted the major quiescent naive T cell subset and en

242 rontal and default mode network regions, and disrupted the relationships between memory performance a

243 Loss of MGP or its BMP4-binding capacity disrupted the retinal vasculature, resulting in poorly f

244 lls during the contraction phase temporarily disrupted the rhythmic pattern.

245 that prenatal exposure to bisphenol A (BPA) disrupted the transcriptome profiles of genes in the off

246 Inhibiting alpha2delta-1 with gabapentin or disrupting the alpha2delta-1-NMDAR interaction with alph

247 catalysis-mediated signaling without grossly disrupting the cellular architecture.

248 Indeed, disrupting the correlations between neural activities de

249 treatment inactivates bacteria by physically disrupting the integrity of the cell membrane.

250 ccess of spillovers can depend critically on disrupting the link between identity and tradition.

251 e progression could potentially be slowed by disrupting the machinery of cell migration.

252 esults in male-biased litters by selectively disrupting the motility of X-bearing sperm cells.

253 he azimuthal position of tropomyosin, likely disrupting the mutant thin filament response to calcium.

254 ciency augmented ERK phosphorylation without disrupting the normal lens fiber gene expression.

255 The compound is capable of disrupting the PD-1/PD-L1 complex by antagonizing PD-L1

256 Indeed, disrupting the putative interaction between a highly con

257 can persist even in the absence of mutations disrupting the silencing pathway.

258 kinase that constitutively inhibits I(Kv1.5) Disrupting the Src-binding motif of Kv1.5 through N-term

259 he outer membrane of gram-negative bacteria, disrupts the alveolar-capillary barrier, triggering pulm

260 By contrast, the m42C modification disrupts the C:G pair and significantly decreases the du

261 Maternal immune activation (MIA) disrupts the central innate immune system during a criti

262 Whereas the disulfide in M112 disrupts the closed conformation to increase k(off), the

263 A single mutation in the RIFIN disrupts the complex, blocks LILRB1 binding of all teste

264 Biochemical assays confirmed that PNP disrupts the GCV system by competing with PLP in GcvP pr

265 c ablation of X-box binding protein 1 (XBP1) disrupts the hepatic 12-hour clock and promotes spontane

266 the aggregates during polymerization, which disrupts the ideal ordering of monomers inside fibrin pr

267 We show that CLK8 disrupts the interaction between CLOCK and BMAL1 and int

268 simulation revealed that the R1060C mutation disrupts the intramolecular interaction between the POLD

269 We further provided evidence that TGF-beta disrupts the lineage commitment and promotes the accumul

270 ypically a consequence of tissue injury that disrupts the local blood supply but can also occur where

271 ively dividing cells, such as cancer cells - disrupts the longitudinal ordering of the molecules in c

272 D increases neuroinflammation in WT mice and disrupts the neuroinflammatory response in 5xFAD mice an

273 onic deletion of integrin beta1 in the liver disrupts the normal development of hepatocyte polarity,

274 in mPOA both suppresses gregarious song and disrupts the positive association between affective stat

275 A Borealin mutant that specifically disrupts the Sgo1-Borealin interaction results in defect

276 channels, receptors and transporters without disrupting their structure.

277 onstrain intracellular parasite infection by disrupting their vacuole membranes.

278 of PRC1 enzymatic activity does not directly disrupt these interactions.

279 ellular components using small molecules can disrupt these rhythms, causing a phase shift, and we aim

280 owever, lesion of VTA GABA neurons failed to disrupt this effect.

281 imulated production of biologics designed to disrupt this essential RNA-protein interface.

282 r example Antimicrobial peptides (AMPs), can disrupt this protective barrier by formation of leaky po

283 urbations of microtubules and motor proteins disrupt this sequence of events.

284 tiation rate of developing human neurons and disrupting this process impacts the function of nascent

285 ns and illustrates the downstream effects of disrupting this process on sensory and motor circuits.SI

286 Unless the food matrix is disrupted through breeding or post-harvest treatments, a

287 ng during mealtimes and unscheduled snacking disrupts timed metabolic processes, which further contri

288 herapy-induced OM involve interactions among disrupted tissue structures, inflammatory infiltrations,

289 found that TOGARAM1 variants cause JBTS and disrupt TOGARAM1 interaction with ARMC9.

290 Cas9 (CRISPR-Cas9) and transposon vectors to disrupt Trp53 and overexpress C-Myc (Trp53(KO)/C-Myc(OE)

291 Mutations disrupting tubulin binding decrease microtubule density

292 statin A-4 phosphate (CA4P) is a microtubule-disrupting tumour-selective vascular disrupting agent (V

293 cal environment within secondary particle is disrupted upon cycling, it triggers charge distribution

294 GT has been applied to associate likely-gene-disrupting variants encoded from whole genome sequence d

295 our data show that heterozygous, likely gene-disrupting variants in SCAF4 are causative for a variabl

296 entally persistent industrial compounds that disrupt various metabolic pathways.

297 related to transient upper airway narrowing disrupting ventilation, and causing oxyhemoglobin desatu

298 ntal GABAergic interneurons was specifically disrupted, whereas input onto pyramidal neurons remained

299 ult, interactions between species can become disrupted, with potentially detrimental effects.

300 ffects (mind wandering and metacognition) in disrupting working memory, and (3) demonstrate how insuf