ライフサイエンスコーパス: disruption

1 cting 50% of the population compared with no disruption).

2 r smooth muscle cells can drive an hour-long disruption.

3 arousals suggests its participation in sleep disruption.

4 inking impaired swim bladder inflation to TH disruption.

5 lso be applied to other targets of endocrine disruption.

6 biomarkers specific to vertebrate endocrine disruption.

7 ndered them more susceptible to chemogenetic disruption.

8 ly life stage development precedes metabolic disruption.

9 le to independently confirm a tight junction disruption.

10 hanistic pathways that could be targeted for disruption.

11 n of inter-endothelial cell gaps and barrier disruption.

12 ions were predicted to result in coding exon disruption.

13 helial barrier against calcium entry-induced disruption.

14 the COVID-19 pandemic and attendant economic disruption.

15 nd two nights of forced awakening (FA) sleep disruption.

16 er thinning with outer plexiform layer (OPL) disruption.

17 ccompanied by gastrointestinal and metabolic disruptions.

18 The results indicated that Clk disruption abolished normal rhythmic expression of miR-3

19 GEP1 disruption abolishes XA-stimulated cGMP synthesis and th

20 V-related deaths over a 1-year period due to disruptions affecting 50% of the population compared wit

21 e direct formation of top shapes from single disruption alone can explain the relatively old crater-r

22 indings to humans by examining whether sleep disruption alters morphine's analgesic and hedonic prope

23 r without (n = 90) blood-brain barrier (BBB) disruption and a diseased control group with cluster hea

24 ecision-making to region-specific Nrxn1alpha disruption and changes in value-modulated neural activit

25 have adverse effects on health by metabolic disruption and immunity suppression.

26 eatment with Tat-A and Tat-B caused membrane disruption and pore formation in HeLa and BE(2)-C cells

27 cies through, among other effects, endocrine disruption and reproductive impairment.

28 macrophages, and neutrophils), elastic fiber disruption, and an increase in smooth muscle cell alpha-

29 ical pathogens, mediated by energy resources disruption, and finally safety for human gut tissues.

30 The mechanisms underlying this disruption are poorly understood.

31 Our results argue that large NADW disruptions are more easily achieved than previously app

32 ight junctions (TJ), strongly implicating TJ disruption as a critical step in antigen responsiveness.

33 ure, mitigate the risks for significant care disruptions associated with social distancing behaviors,

34 The results suggest that white matter disruptions at specific locations of the cingulum bundle

35 ay alleviate ER stress associated with YIPF5 disruption by decreasing the demand for insulin secretio

36 ur data uncover a regulatory mechanism whose disruption by maternal food choices could limit an offsp

37 Such disruption can predispose the hybrids to abnormalities a

38 Emerging evidence indicates that these disruptions can be related to abnormal interoception (i.

39 Pathogenic domain disruptions can result from chromosomal rearrangements o

40 be taken into account in models of the clock disruption-cancer connection.

41 Concerns exist that these disruptions caused by the pandemic may not have influenc

42 outer retinal atrophy (e.g., ellipsoid zone disruption), components of complete retinal pigment epit

43 up selected for further studies of endocrine disruption consisted of continuous AC(50) data from the

44 More specifically, disruption corresponded prominently to the "salience" ne

45 Preclinical studies demonstrate that sleep disruption diminishes morphine analgesia and modulates r

46 s are commonly used to evaluate sensorimotor disruption due to ethanol (EtOH).

47 Minimal mechanical disruption during digestion, warm enzymatic digestion us

48 both PDXK and PLP levels recapitulated PDXK disruption effects.

49 uld have the largest impact of any potential disruptions, effects of poorer clinical care due to over

50 e temporarily destabilized and vulnerable to disruptions, followed by reconsolidation.

51 on about the phenotypic consequences of gene disruption: genes that are crucial for the function of a

52 rmation of precise neural circuitry, and its disruption has been linked to neurodevelopmental disorde

53 ncreased food insecurity, household economic disruption, household stress, and interruptions in healt

54 This disruption impairs the regulatory functions of the prote

55 Furthermore, astrocyte-specific Trpa1 disruption in a mouse brainstem-spinal cord preparation

56 HGA-derived pigment composition and collagen disruption in AKU cartilage.

57 onavirus disease (COVID-19) has caused major disruption in all aspects of healthcare.

58 hemical associated with metabolic and immune disruption in animals and humans.

59 d more severe colitis than mice without Tgr5 disruption in ISCs.

60 Memory disruption in mild cognitive impairment (MCI) and Alzhei

61 Gene disruption in mouse embryonic stem cells or zygotes is a

62 , in the case of citric acid, there was some disruption in performance at higher concentrations.

63 Experimental sleep-wake disruption in rodents and humans causally modulates beta

64 opagation in culture and prevented epidermal disruption in skin explants.

65 We further investigated whether IL-4Ralpha disruption in systemically sensitized mice can prevent t

66 Our findings implicate a marked nonvascular disruption in T1D of several essential neural nodes enga

67 ngency plans are evolving in case of further disruption in the 2020-2021 academic year.

68 amily B GPCR-G(s) protein complexes reveal a disruption in the alpha-helix of transmembrane segment 6

69 ently proposed that the disease is caused by disruption in the function of presynaptic homomeric GlyR

70 ew of all risk factors associated with sleep disruption in the ICU setting.

71 patients with AUD, and the severity of this disruption in turn predicted greater heavy drinking duri

72 er types, of the frequency of homozygous TSG disruption in wild-type hosts compared to those with an

73 Disruptions in astrocyte function following loss of NFIA

74 system has a remarkable tolerance for major disruptions in chromatin structure and reveal a role for

75 reduce host vulnerability to stress-induced disruptions in complex behaviors such as sleep.

76 ce PAI-1 as a negative regulator of eNOS and disruptions in eNOS-PAI-1 binding promote increases in N

77 racts on the lesion side exhibited prominent disruptions in fiber orientation, integrity and myelinat

78 sults from neuroimaging studies suggest that disruptions in flexible decision-making functions in sub

79 he pandemic, including those associated with disruptions in health care systems and the economic and

80 However, the frequency of domain disruptions in human cancers remains unclear.

81 Disruptions in L-tryptophan metabolism are reported in s

82 rigin of disorders of childhood that involve disruptions in large-scale network connectivity.

83 (CNgV) cellular composition prefigure these disruptions in LgDel embryos.

84 mGlu5 signaling may be a mechanism by which disruptions in negative-outcome updating emerge in cocai

85 Disruptions in neural tube (NT) closure result in neural

86 giogenesis, oxidative stress) causes various disruptions in offspring, including ones in white matter

87 understanding of functional neuroanatomy and disruptions in psychiatric disorders.

88 ts reveal the magnitude of the hydroclimatic disruptions in the highest reaches of the Amazon Basin t

89 To understand potential pandemic-related disruptions in the transportation network of kidneys acr

90 ptic functions, with particular focus on how disruptions in these processes may contribute to the pat

91 Disruptions in this equilibrium directly impact neutroph

92 ut microbes exhibit diurnal rhythmicity, and disruptions in this rhythmicity potentially impact host

93 E28H causes a pH-dependent fraction of helix disruption, in which the helix breakage increases from 2

94 llular diffusion of ozone after the membrane disruption induced by LEEFT.

95 This disruption is correlated with depletion of the populatio

96 r, calcium entry-induced endothelial barrier disruption is decreased by S100A6 dependent upon PPP5C,

97 eruginosa to activate the T6SS even when the disruption is generated by aberrant cell envelope biogen

98 fold protein in excitatory synapses, and its disruption is implicated in neurodevelopmental disorders

99 gregation in this in vitro system, transport disruption is not due to nucleocytoplasmic transport pro

100 eins in thrombin-induced endothelial barrier disruption is unveiled.

101 eds of cell lines has identified genes whose disruption leads to fitness defects, a critical step in

102 MH led to significant reductions in vascular disruption, leukocyte accumulation, and demyelination.

103 As continued COVID-19 disruption looks likely across the world, perhaps until

104 We propose that PbYOP1's disruption may lead to defects in trafficking and secret

105 cocious stream departure ex vivo, and stream disruption, morphological changes and abnormal allocatio

106 Evaluating a ctpD disruption mutant demonstrated a previously unknown role

107 nge 229 023-420 000) if such a high level of disruption occurred.

108 FACT then depends on the level of chromatin disruption occurring in the cell, and the cell's ability

109 d wobble codons on the ribosome revealed the disruption of a C(32-)A(38) cross-loop interaction but f

110 lagging strand DNA synthesis, the efficient disruption of a nucleosome barrier by Pif1 could lead to

111 Moreover, disruption of a PDZ binding domain within PKCalpha led t

112 ransport in d-Ser toxicity was unsurprising, disruption of a single transporter, CycA, was sufficient

113 elective P2Y(11) agonist NF546 is blocked by disruption of A-kinase anchoring protein 5 (AKAP5) funct

114 Furthermore, by examining the disruption of ACE2 in several comorbid diseases, we offe

115 disease model were accompanied by increased disruption of airway epithelium, which was reversed by t

116 or beta4 spectrin alone, including profound disruption of AIS Na(+) channel clustering, progressive

117 vation of lysosomal degradation enzymes, and disruption of antigen presentation pathways.

118 Disruption of APC results in pathologic stabilization of

119 genesis results from folding defects and the disruption of autoinhibition and activation.

120 Disruption of autophagy is associated with neuronal dysf

121 in various disease states and, consequently, disruption of BET-KAc binding has emerged as an attracti

122 of when and how abruptly this climate-driven disruption of biodiversity will occur is limited because

123 Disruption of BMP signaling can trigger cardiovascular d

124 - and optogenetic inhibition of MEC led to a disruption of border coding in RSC, but not vice versa,

125 earning-resistant fear behavior results from disruption of brain components not previously implicated

126 Global disruption of calcitonin receptor signalling in mice cau

127 ich is associated with loss of T-tubules and disruption of cardiac dyads.

128 Thus, the disruption of CD133 signal to PI3K pathway is essential

129 Thus, disruption of CDCP1 perturbs pro-cancerous Wnt signaling

130 as accompanied by a selective and pronounced disruption of cell-type-specifying transcriptional circu

131 ough focal adhesion kinase inhibition caused disruption of cellular actin organization.

132 We next induced severe disruption of circadian rhythms by exposing ApoE(-/-) mi

133 ibly milder but much more common and chronic disruption of circadian rhythms in the general populatio

134 ved Neurospora clock mutants each arise from disruption of ck-1a regulation is consistent with circad

135 Disruption of clathrin-mediated endocytosis did not affe

136 Moreover, we observed intrastrand disruption of collagen triple helix in pigmented AKU hum

137 Interestingly, disruption of coronin 1 promotes allograft tolerance whi

138 Disruption of CovS kinase or phosphatase activities abol

139 tMCAO and TLR2 stimulation, in both models, disruption of CX3CR1-CCR2 signaling attenuated both mono

140 Disruption of each of these essential cellular functions

141 Disruption of either gene did not alter the low-level bi

142 isoforms, expression levels, promoters, and disruption of endogenous genes in transgenic mouse model

143 s that lead to coral bleaching (that is, the disruption of endosymbiosis), which in turn leads to cor

144 ne the impact of acute CMV infection on: (a) disruption of established transplantation tolerance duri

145 Genetic disruption of Ftz-f1 expression prevents follicle cell d

146 mulation and monitoring for 2 months without disruption of functional behavior.

147 Critically, disruption of GAL5.1 in mice using CRISPR genome editing

148 substrate level phosphorylation via genetic disruption of glycolysis leads to rapid sterilization.

149 Disruption of GPRASP/CXCR4 interactions could be exploit

150 Consequently, disruption of habenular neurons reduces capture performa

151 -5 child deaths resulting from the potential disruption of health systems and decreased access to foo

152 s (testosterone and DHEA) that contribute to disruption of hippocampal brain development, which in tu

153 pression, we identified specific and delayed disruption of hippocampal-mPFC synaptic transmission and

154 Disruption of human BA-implicated HSP90 pathway genes se

155 Interestingly, similar disruption of ID nanodomains has been identified in atri

156 tion for yield may entail a hidden cost: the disruption of interactions between plants and beneficial

157 t confers antiviral protection but minimizes disruption of intestinal homeostasis.IMPORTANCE Enteric

158 Genetic disruption of irf6 and esrp1/2 in zebrafish resulted in

159 ed to examine if moderate Nrf2 activation by disruption of Keap1 impacts bone metabolism.

160 Moreover, disruption of Kindlin-3-PXN/LPXN binding promoted the tr

161 icking the effect of advanced aging, genetic disruption of lysosomal function accelerated the accumul

162 r phenotype has been described for mice with disruption of M1ap.

163 C) mice) or tamoxifen-inducible IEC-specific disruption of Mcl1 (i-Mcl1(DeltaIEC) mice); these mice a

164 We generated mice with IEC-specific disruption of Mcl1 (Mcl1(DeltaIEC) mice) or tamoxifen-in

165 Mechanistically, we show that the disruption of mitochondria-endoplasmic reticulum (ER) co

166 f increased stress resistance, we found that disruption of mitochondrial fusion genes resulted in the

167 Disruption of mitochondrial homeostasis could lead to ce

168 trongest cis effects are associated with the disruption of motifs recognized by strong transcriptiona

169 Disruption of mTOR signaling can result in neurological

170 deficiency can occur independent of genetic disruption of NAD biosynthesis.

171 se magnetoencephalography (MEG) to show that disruption of network dynamics may be responsible.

172 a change in neural circuit connectivity and disruption of normal behavior.

173 a congenital malformation resulting from the disruption of normal urethral formation with varying glo

174 Disruption of nucleocytoplasmic transport is increasingl

175 -B cells reveal a strong correlation between disruption of nucleoli, reduced association of RAG1 with

176 n cells depleted of CTCF or cohesin, whereas disruption of nucleosome contacts alters their structura

177 showed that tolerance could be attributed to disruption of one of two d-Ser transporters and/or activ

178 The disruption of ordered water molecules confined within hy

179 Targeted disruption of Paneth cell lysozyme (Lyz1) protected mice

180 The disruption of pathologically enhanced beta oscillations

181 Our results suggest that EP-mediated direct disruption of pericytes by PGE2 is a key process for vas

182 ons in SCZ, these studies support a role for disruption of PI3K/GSK3 signaling as a risk factor for S

183 Conditional endothelial-specific disruption of Piezo1 in adult mice suppressed the expres

184 Disruption of PIMMS43 in the rodent malaria parasite Pla

185 to test whether these errors are due to the disruption of pioneer projections from prethalamus to th

186 Unilateral disruption of plantar sensation causes able-bodied indiv

187 nction of individual PRC2 core proteins, the disruption of PRC2 complex formation, and the degradatio

188 onses.SIGNIFICANCE STATEMENT A developmental disruption of prefrontal cortex maturation has been impl

189 r and maybe hypothetically attributed to the disruption of proprioceptive facial feedback reinforcing

190 Disruption of protein folding in the endoplasmic reticul

191 We conclude that germline disruption of PTEN, both in human and mouse, results in

192 We found that disruption of PTPN14 binding through mutation of the C-t

193 in conjunction with strategies that involve disruption of pyruvate homeostasis and indicate possible

194 enzazepine, and mice with intestine-specific disruption of Rbpj.

195 nce of hippocampal IEDs was accompanied by a disruption of recognition of familiar images only if the

196 than ABE7.10, which could benefit screening, disruption of regulatory regions and multiplex base edit

197 During phagocytosis, we find that disruption of RGBARG causes a geometry-specific defect i

198 ited metabolic reprogramming in concert with disruption of several Warburg effect-related super-enhan

199 est that therapeutic strategies based on the disruption of SHH/PTCH interaction in SHH-overexpressing

200 Moreover, the additional disruption of SMXL4 activity increases tissue production

201 recipient allo-sensitization by CMV-mediated disruption of stable tolerance.

202 omophore's molecular conformation (including disruption of strong hydrogen bonding and novel conforme

203 The formation and disruption of synaptic connections during development ar

204 This disruption of synaptic connectivity is linked to working

205 concordant relationship between the gain or disruption of TF (transcription factor)-binding motifs,

206 Disruption of Th17-Treg cell balance is implicated in a

207 MRgFUS allows for the temporary and repeated disruption of the BBB.

208 tin receptor-positive (LepR+) cells led to a disruption of the BM perivascular niche.

209 the digestion of genomic DNA, and (iii) the disruption of the cell membrane.

210 ergic neurons, suggesting that falls reflect disruption of the corticostriatal transfer of movement-r

211 c oxide reductases (FNORs) is related to the disruption of the defense mechanism in mammals against i

212 adverse childhood experiences and stress to disruption of the development of neural systems supporti

213 istinct mode of LPS action that, through the disruption of the early coordinated non-lytic cell death

214 Disruption of the fast VCS gene regulatory network allow

215 higher lutein and beta-carotene absorption, disruption of the food matrix by prior cooking results i

216 Remarkably, we also found that the disruption of the fpn gene led to a strong reduction in

217 Disruption of the fusome, a large cytoplasmic structure

218 The disease state is usually preceded by disruption of the host microbiome in response to antibio

219 gnal-transducing adaptor molecule 1) because disruption of the interaction between STAM1 and beta-arr

220 Disruption of the intestinal microbiota and immune respo

221 osure to SPT-enol leads to larval arrest and disruption of the life cycle.

222 Disruption of the LINC complex prevented RAC1-induced nu

223 increase of transcriptional output owing to disruption of the MDM2-negative feedback loop.

224 Disruption of the minor spliceosome due to mutations in

225 Moreover, despite the disruption of the mitochondrial mitofilin protein comple

226 sion appeared to be directly involved in the disruption of the mitochondrial network, as the mitochon

227 Bearing a Cre-LoxP induced exonic disruption of the murine Gaa gene, this model is also no

228 t (DNA-PKcs) recruitment and activation, and disruption of the MutS homologue 2 (MSH2)-ATR module.

229 Disruption of the NAD(+)-binding site or the ARM-TIR int

230 It is clear that disruption of the normal bone marrow microenvironment is

231 004 and P = 0.03, respectively), and loss or disruption of the photoreceptor zone, ellipsoid zone, an

232 We induced nephron-specific disruption of the Pkd1 gene in 3-month-old mice and exam

233 form of necrosis that relies on the physical disruption of the plasma membrane once the peptide targe

234 Disruption of the ppm1f gene in mice results in early em

235 initiation significantly affected functional disruption of the prefrontal-striatal responses to stres

236 uronal targets are involved in this process; disruption of the prototypic target-derived neurotrophic

237 ransformations of the vesicles, specifically disruption of the spherical shapes, reduction of vesicle

238 ressive effects of mutant p53 were driven by disruption of the WNT pathway, through preventing the bi

239 ers of DNA damage repair caused by biallelic disruption of the WRN or BLM DNA helicases respectively.

240 inhibition of islet electrical activity and disruption of their coordination.

241 erapeutic load inside exosomes often involve disruption of their membrane, which may jeopardize their

242 Disruption of these events in human cells prevented the

243 Disruption of these interactions by single mutation of L

244 Indeed, mutational disruption of these interactions resulted in constitutiv

245 Disruption of these mechanisms affect mitochondrial func

246 Disruption of these microdomains promotes oxidative stre

247 Moreover, disruption of these pathways is implicated in neuromuscu

248 Disruption of these pathways may perturb network functio

249 Disruption of these ZIKV NS5-hSTAT2 interactions comprom

250 Disruption of this 3' tagging has a significant but limi

251 Disruption of this correlation renders the ribosome unab

252 taining the alpha5 subunit encoded by Chrna5 Disruption of this gene impairs attention, but the advan

253 and colorectal cancer fundamentally reflects disruption of this homeostatic signaling.

254 However, disruption of this interaction via mutation of the KIX d

255 cycle amplification loop is established, and disruption of this loop disables the EBV lytic cascade.

256 ethylation and explore growing evidence that disruption of this regulatory pathway contributes to neu

257 Disruption of this stem abolishes the non-coding, but no

258 Disruption of transcription factor gene Prdm16 during mo

259 V-1), and cellular stresses cause widespread disruption of transcription termination (DoTT) of RNA po

260 fects of identified agents in zebrafish with disruption of ttc7a, which develop intestinal defects, a

261 nteraction modulates antiviral signaling via disruption of USP7 interactions with innate immune signa

262 abolism, cognitive impairment and widespread disruption of WM structure occur in an early course of s

263 F220C mice exhibited minor disruptions of photoreceptor outer segment dimensions wi

264 These observations suggest that small disruptions of quaternary structure are sufficient for f

265 tabolism in PDAC and the consequences of its disruption on tumor progression.

266 Disruption or dysfunction of cholesterol trafficking lea

267 strand DNA breaks (DSBs) can result in gene disruption or gene modification via homology directed re

268 Disruption or imbalance in homeostasis results in functi

269 tage of DRIL (P < 0.0001), percentage of ELM disruption (P < 0.0001), percentage of EZ disruption (P

270 LM disruption (P < 0.0001), percentage of EZ disruption (P = 0.0003), and percentage of IZ disruption

271 isruption (P = 0.0003), and percentage of IZ disruption (P = 0.0018).

272 PDXK disruption reduced intracellular concentrations of key m

273 Emei disruption reduces ER Ca(2+) level and subsequently lead

274 critical target for developmental endocrine disruption, resulting in altered neuroendocrine control

275 In cancer cells, this "metabolon disruption" results in a decrease in lactate transport,

276 Genetic disruptions revealed that short Abeta oligomers induce a

277 thways to prioritize chemicals for endocrine disruption testing.

278 hat chronic exposure to IFNs induces barrier disruption that allows for higher S. aureus colonization

279 tal heart defects, localized ultrastructural disruptions that increase the risk of heart failure are

280 In addition to myocardial architecture disruption, this effect can be attributed to an EpAT-car

281 litate phage administration while minimizing disruption to host processes, we develop an aqueous-base

282 ovide compelling support for AOPs linking TH disruption to impaired AC inflation in fish.

283 cting the patient-clinician dynamic, with no disruption to the clinical workflow, and needs to operat

284 ing memory and reasoning performance whereas disruption to the reasoning subnetwork relates to reason

285 Disruption to the transmembrane protein linkage between

286 Novel research suggests that disruption to the transmembrane protein linkage between

287 f node-centric measures and is asymmetrical: disruption to the working memory subnetwork relates to b

288 e GABA(A) agonist, muscimol, induced general disruptions to behaviour.

289 In mouse models of AD, there are disruptions to sharp wave ripples (SWRs), hippocampal po

290 g against future climate or other unexpected disruptions to the food system.

291 Disruptions to the seasonal transmission patterns of the

292 We review evidence for diabetes-related disruptions to three critical circuits for movement cont

293 lls using CRISPR/Cas9-mediated targeted gene disruption under the aegis of p53siRNA in the mouse mode

294 tigated controlled blood-brain barrier (BBB) disruption using a low-frequency clinical transcranial M

295 Therefore, predicting potential endocrine disruption via exogenous chemicals requires that aromata

296 Insertion sequence disruption was limited to mgrB (P < .001).

297 Among the 5% most significant periods of disruption, we identify the 'big five' mass extinction e

298 Molecular disruptions within limbic brain regions and the peripher

299 To treat the deficit arising from Chrna5 disruption without triggering desensitization, we enhanc

300 eased ability to fish (due to infrastructure disruptions), would affect global catches, and test the