ライフサイエンスコーパス: disruptive

1 int stratigraphy before their effect becomes disruptive.

2 usive visual memories may be distressing and disruptive.

3 ar inflammation in a manner that is not host disruptive.

4 missense variants carried per individual are disruptive, a higher proportion than previously reported

5 hysical approaches we characterized membrane disruptive activity of the full-length PB1-F2 (90 amino

6 yplex size, stability, pH-dependent membrane disruptive activity, biocompatibility, and gene silencin

7 of Skin focused on provocative, potentially disruptive advances, including crowdsourcing of patient

8 -intensity focused ultrasound and a chemical disruptive agent (ethanol) was examined in vitro and in

9 amilial; however, thus far no rare germ line disruptive alleles for CLL have been identified.

10 In stark contrast, disruptive alleles of Basket (Bsk), the Drosophila homol

11 1 unrelated Japanese patients, we identify a disruptive Alu insertion and a nonsense variant (p.Arg19

12 Such disruptive analyses potentiate contamination, disrupt th

13 Less disruptive and costly NPIs can be as effective as more i

14 ort-pulse ultrasound sequence is a minimally disruptive and efficient drug delivery method that could

15 gle-cell resolution yet in a label-free, non-disruptive and mechanism-specific manner can lead to man

16 agnetic implant that was developed as a less disruptive and more reproducible surgical option for pat

17 We found that gene-disruptive and putatively protein-damaging URVs (but not

18 ion is typically assumed to be maintained by disruptive and/or fluctuating selection; hence, the some

19 This rapid, robust, less disruptive, and cost-effective technology adds a valuabl

20 tion technology is facile, versatile and non-disruptive, and in addition to tissue oxygenation, it sh

21 clonal expansion of HSPCs carrying specific, disruptive, and recurrent genetic variants, in individua

22 naging infections and proposes 3 potentially disruptive applications for these data in the clinical w

23 uals ascertained for the presence of a known disruptive ASD-risk mutation that is 1) CHD8 (CHD8 group

24 the idea that most pathogenic mutations are disruptive at a structural level.

25 beyond observers' oculomotor range via their disruptive, attention capturing costs for endogenous att

26 ed the magnitude of vocal learning driven by disruptive auditory feedback in a negative reinforcement

27 Disruptive auditory stimulation degraded sleep with freq

28 antecedents of new adolescent-onset MDD, but disruptive behavior (beta = -0.08, P = .14) and low mood

29 Parents rated disruptive behavior and noncompliance on co-primary outc

30 o assessed 14 lifetime DSM-IV mood, anxiety, disruptive behavior and substance disorders before rando

31 Children with early-onset disruptive behavior disorder (DBD), especially those wit

32 e most consistent dysfunction in youths with disruptive behavior disorder is in the rostro-dorsomedia

33 Across 24 studies, 338 youths with disruptive behavior disorder or conduct problems relativ

34 all whole-brain fMRI studies of youths with disruptive behavior disorder or conduct problems up to A

35 Youths with disruptive behavior disorder with psychopathic traits sh

36 Youths with disruptive behavior disorders (DBD) (conduct disorder an

37 processing is implicated in the etiology of disruptive behavior disorders (DBDs) and callous-unemoti

38 Major depressive episodes and disruptive behavior disorders are also indications for c

39 Furthermore, brain changes associated with disruptive behavior disorders should not simply be under

40 aim of this meta-analysis of fMRI studies in disruptive behavior disorders was to establish the most

41 Causal pathways to disruptive behavior disorders, even within the same diag

42 lt in more truly integrated investigation of disruptive behavior disorders, which holds the promise o

43 d developmental trajectories associated with disruptive behavior disorders.

44 d developmental trajectories associated with disruptive behavior disorders.

45 f white matter connectivity in children with disruptive behavior have yielded inconsistent results, p

46 Disruptive behavior is common in children with autism sp

47 of evidence, the authors conclude that early disruptive behavior is neurodevelopmental in nature and

48 as superior to parent education for reducing disruptive behavior on parent-reported outcomes, althoug

49 described empirically derived dimensions of disruptive behavior problems using the Child Behavior Ch

50 fic white matter connectivity with childhood disruptive behavior problems, while accounting for their

51 ing the multidimensional nature of childhood disruptive behavior traits shows promise in advancing th

52 nvolved party (IP) responses to determine if disruptive behavior was inherent to the surgeon or the h

53 urodevelopmental research on early childhood disruptive behavior within the historical context of the

54 oint Commission mandated a process to manage disruptive behavior, as evidence suggests it undermines

55 y were not associated with broad measures of disruptive behavior, e.g., Child Behavior Checklist exte

56 ehavior, a severe manifestation of childhood disruptive behavior, was associated with lower white mat

57 lous behavior as two core exemplars of early disruptive behavior.

58 epression and peer ratings of aggression and disruptive behavior.

59 with severe intellectual disability (ID) and disruptive behavior.

60 or elucidating neurobiological correlates of disruptive behavior.

61 fered for parents of preschool children with disruptive behavioral problems screened from the whole p

62 creening criteria indicating a high level of disruptive behavioral problems.

63 dence-based early treatment of children with disruptive behavioral problems.

64 ipid-peptide interactions governing membrane-disruptive behaviors and establish a link between peptid

65 f differential expectations and responses to disruptive behaviors by gender will be important for cul

66 3-7 years) with autism spectrum disorder and disruptive behaviors were randomly assigned (86% white,

67 sed systemic treatments for adolescents with disruptive behaviour problems exist.

68 sed systemic treatments for adolescents with disruptive behaviour.

69 ntion efficacy can be enhanced by mitigating disruptive bottom-up influences such as stress, training

70 ines and patient-derived tumors, with highly disruptive BRCT domain mutations, have readily detectabl

71 that might be found in nature, edge enhanced disruptive camouflage increases crypsis, even on substra

72 e enhancement increases the effectiveness of disruptive camouflage through mechanisms that may includ

73 Other patterns resemble disruptive camouflage, whereas the chin and jugal bosses

74 ucture, thus contributing to strong membrane disruptive capability and potent antimicrobial activity.

75 ir activities in time, thus increasing their disruptive capacity.

76 ) poor planning for medical setbacks; and 5) disruptive care transitions.

77 or-binding sequence and hydrophobic membrane-disruptive chains that are masked by acid-cleavable gala

78 An artificial, disruptive challenge; i.e., introduction of a novel obje

79 ave not durably increased transplant access, disruptive change is clearly needed.

80 The approach has the potential to bring disruptive change to drug discovery; the many potential

81 These disruptive changes thus led to a dis-organization of F-a

82 A sequencing, have ushered in widespread and disruptive changes to biomedical research.

83 erms of environmental footprint and possible disruptive chemistries to meet the energy storage needs

84 We identified 17 individuals with exon-disruptive CNVs (18.5%), including 13 different deletion

85 In addition, we provide evidence of gene-disruptive CNVs (in DISC1, WNT7A, RBFOX1, and MBD5), as

86 Probands carry more gene-disruptive CNVs and SNVs, resulting in severe missense m

87 mechanisms, of which background matching and disruptive coloration are likely the most common.

88 In contrast, disruptive coloration, which disguises body outlines, ma

89 Disruptive colouration is a visual camouflage composed o

90 in the Enhancing condition, and lower in the Disruptive condition, versus Sham.

91 ge-related change in FC: "conservative" and "disruptive." Conservative development was characteristic

92 As endocrine disruptive contaminants in the environment, SSRIs affect

93 pate in different signaling pathways without disruptive cross-talk.

94 proteins at the cell-cell interface and also disruptive cytoskeletal organization of F-actin and MTs

95 Disruptive, damaging ultra-rare variants in highly const

96 Disruptive, damaging ultra-rare variants in highly const

97 uctural variants, and three with potentially disruptive de novo missense variants.

98 ty has already been established by recurrent disruptive de novo protein-coding mutations (ARID1B, SCN

99 f these genes, 49 show higher frequencies of disruptive de novo variants in individuals ascertained t

100 protocols involve time-consuming, harsh and disruptive deoxygenation methods, while "grafting to" ap

101 Disruptive development was characteristic of association

102 This article proposes a disruptive device concept which meets both low power and

103 [HR], 2.02; 95% CI, 1.08-3.79; P = .03), any disruptive disorder (HR, 1.70; 95% CI, 1.05-2.75; P = .0

104 We hypothesized that the disruptive ecological changes triggered by the earthquak

105 twork positions, have a strong topologically disruptive effect and touch complexes with high function

106 This membrane-disruptive effect is enhanced for gel phase DMPC membran

107 This disruptive effect of stress on working memory has been l

108 ntrols, ie, impairment in sensitivity to the disruptive effect of such interference.

109 , and showed that STN inhibition reduced the disruptive effect of surprise.

110 nome-wide screens for genes that mediate the disruptive effect of thrombin on endothelial cell juncti

111 n equivalent, or undoubtedly a much greater, disruptive effect on mnemonic and cognitive functions.

112 age mechanisms: pattern complexity matching, disruptive effects and background color matching.

113 at regulates unc-9 electrical signaling; its disruptive effects can be rescued by a constitutively ac

114 At the molecular level, we found that these disruptive effects did not require arrestin-dependent si

115 Cerebellar rTMS was able to reverse the disruptive effects of a 'virtual lesion'.

116 at IL-10 deficiency predisposes to pregnancy disruptive effects of environmental toxicants.

117 itive genes have evolved a robustness to the disruptive effects of genetic variation by expanding the

118 and was significantly less vulnerable to the disruptive effects of IFN, cellular restriction factors,

119 ed and systematic differences in the protein-disruptive effects of mutations caused by different muta

120 k for understanding sterol transport and the disruptive effects of mutations causing sitosterolaemia.

121 ant for developing lighting that reduces the disruptive effects of nocturnal light in humans, without

122 The disruptive effects of stress on the pattern of BLA funct

123 ur results suggest a novel mechanism for the disruptive effects of the absence or haploinsufficiency

124 found to induce Sertoli cell injury through disruptive effects on actin microfilaments and microtubu

125 ability (ID) patients that showed convergent disruptive effects on AMPAR recycling and glutamate unca

126 Therefore, we determined if MDPV exerts disruptive effects on brain functional connectivity, par

127 was found to block the NC1-peptide-mediated disruptive effects on cytoskeletal organization in Serto

128 on and task performance revealed that pain's disruptive effects on performance were mediated by self-

129 ese findings thus illustrate PFOS exerts its disruptive effects on Sertoli cell function downstream t

130 These mutations lead to corresponding disruptive effects on synaptic vesicle docking, priming,

131 CAPN14 induces disruptive effects on the esophageal epithelium by impai

132 g elongate spermatid exfoliation through its disruptive effects on the organization of actin- and mic

133 These disruptive effects were relieved by either mutation of t

134 all the nuclear-receptor mediated endocrine disruptive effects, antiandrogenicity is frequently obse

135 ould be considered as a source for endocrine disruptive effects.

136 luding severe aquatic toxicity and endocrine disruptive effects.

137 This work describes a novel and disruptive electrochemical biosensing device that is sel

138 .S. swine producers were confronted with the disruptive emergence of porcine epidemic diarrhoea (PED)

139 ock status, variable management success, and disruptive environmental change.

140 Foot-and-mouth disease (FMD) can cause large disruptive epidemics in livestock.

141 SLFN genes, contained UV/oxidative-signature disruptive epidermal mutations that manifested positive

142 ontrast, we found a single heterozygous exon-disruptive event in a BBS-associated gene (BBS9) in 229

143 brain volume can be altered, by either rare disruptive events causing hyperactivation of the pathway

144 idly emerging societal tensions arising from disruptive events like natural disasters.

145 zations to remain operational in the face of disruptive events.

146 tisense oligonucleotides (PMO-AO) to exclude disruptive exons from the mutant DMD transcript and elic

147 Separating the innocuous from the disruptive exotic species provides a basis for triage ef

148 ents rated noise and light as the most sleep-disruptive factors.

149 ve been considered before to be particularly disruptive for reliable brain function.

150 , suggesting that this event is particularly disruptive for the microbial community, but the transpla

151 t-to-brain metastasis (B2BM) is a common and disruptive form of cancer and is prevalent in the aggres

152 Our data suggest that PCBs impart pregnancy disruptive functions by activating the Notch/Dll pathway

153 It has been reported that unlike a disruptive G-protein-mediated PAR1 signaling by thrombin

154 tanding of the relationships between related disruptive gene events may lead us to improved understan

155 ally, and by probing structurally predicted, disruptive, genetic variants from ciliary disease patien

156 trans paired nicking) mostly overcomes such disruptive genotype-phenotype associations.

157 as hepatocyte growth factor (HGF) and hepato-disruptive GFs such as transforming growth factor (TGF)-

158 uaries subject to repeated intense ecosystem disruptive HABs, the Indian River Lagoon and the St.

159 ect ways to regulate NMDA that would be less disruptive have been proposed and metabotropic glutamate

160 region for days or even weeks, resulting in disruptive heatwaves, droughts, flooding, snowfalls, and

161 etabolism or by infiltrating the system with disruptive, heterologous pathways that overcome cellular

162 esponses in midlatitudes may be ecologically disruptive if interacting taxa respond oppositely to war

163 provides mechanistic insight into a class of disruptive IgE inhibitors that accelerate the dissociati

164 Artificial intelligence has recently made a disruptive impact in medical imaging by successfully aut

165 e diversity in fish mucosae demonstrates the disruptive impact of disease and antibiotic treatment on

166 These findings support the disruptive impact of lights on moth activity, which is o

167 ence elements, recent studies have noted the disruptive impact of mutated generic spliceosome compone

168 heir sensitivity, selectivity, and minimally disruptive impact on biomaterials.

169 CM is promising disruptive improvements in photovoltaic energy conversio

170 gh-performance nanomaterials that will cause disruptive improvements in the field of biosensing.

171 7) for sleep-wake disorders; 12% (10-15) for disruptive, impulse-control, and conduct disorders; 11%

172 ses to identify which SCNA patterns are most disruptive in OV.

173 lated brain areas may simultaneously exert a disruptive influence on neurocircuits involved in volunt

174 Together, these changes are disruptive influences on academic pathology research as

175 ity that its emergence might have evolved by disruptive innovation rather than gradual change.

176 ural firing patterns, typically construed as disruptive 'instability' or an undesirable consequence o

177 in low resolution 2D pillar-based methods or disruptive intermediate steps of cell removal and substr

178 embryo transfer), with no recent exposure to disruptive intrauterine instrumentation (e.g., hysterosc

179 noncovalent peptide formations, increasingly disruptive ionization settings can be used, such as in-s

180 Vortex motion can be disruptive; it can cause phase transitions, glitches in

181 conjugation is demonstrated by rapid and non-disruptive labeling of two enzymes.

182 Recurrent de novo (DN) and likely gene-disruptive (LGD) mutations contribute significantly to a

183 ted that genes with de novo (DN) likely gene-disruptive (LGD) mutations in children with autism spect

184 ith an excess of missense and/or likely gene-disruptive (LGD) mutations.

185 rovides a simple and effective scheme of non-disruptive manipulation of the chemical landscape associ

186 ss cultural space to conduct themselves in a disruptive manner than boys.

187 hin minutes, the birds learned to avoid this disruptive masking (jamming) by adjusting the timing of

188 acterial activity against MRSA by a membrane-disruptive mechanism without detectable toxicity to mamm

189 This disruptive mechanistic insight into chiral polymer thin

190 ious, uncertain, and high-risk trajectory of disruptive medical innovation?

191 Non-disruptive methods avoiding critical steps, such as memb

192 nd replicated new RV associations, including disruptive missense RVs of NPC1L1 and an intergenic regi

193 Bipolar disorder and disruptive mood dysregulation disorder (DMDD) are clinic

194 youths with varying levels of irritability (disruptive mood dysregulation disorder, N=52; anxiety di

195 t-seeking youth with anxiety disorders, with disruptive mood dysregulation disorder, with ADHD, or wi

196 ages 8 to 17 years, 93 youths with anxiety, disruptive mood dysregulation, and/or attention-deficit/

197 Instead of large-scale, disruptive mortality, when contextualized and examined t

198 on the CRISPR/Cas9-mediated correction of a disruptive mutation in Fancf.

199 sequencing of spp3 identified an independent disruptive mutation in SvAUX1 (AUXIN1), one of the two g

200 nd facilitated accommodation of functionally disruptive mutational insults by cis-acting epistatic co

201 cant burden of ultra-rare (MAF < 0.01%) gene-disruptive mutations (FDR 5%), six of which reach family

202 Disruptive mutations (L348R or Delta324-339) lowered the

203 toward an excess of de novo and potentially disruptive mutations among conserved noncoding sequences

204 The rarity of disruptive mutations among unaffected individuals (2/49,

205 Gene-disruptive mutations contribute to the biology of neurod

206 th an excess of de novo mutations or private disruptive mutations in 5.7% of cases.

207 rldwide cohort of 78 individuals with likely disruptive mutations in ADNP from January 2014 to Octobe

208 n TP53 mutations, while cylindromas may have disruptive mutations in DNMT3A.

209 ensitivity was significantly associated with disruptive mutations in genes related to nonhomologous e

210 rum disorders (ASD) have high vulnerability: disruptive mutations in many of these genes, the vulnera

211 al and molecular data of 25 individuals with disruptive mutations in POGZ by diagnostic whole-exome,

212 A total of 8.7% of TGCT families carry rare disruptive mutations in the cilia-microtubule genes (CMG

213 We identify frequent disruptive mutations in the PRC1-like component and BCL6

214 Within this interval, we identified disruptive mutations in two genes.

215 in an explicit test by measuring the load of disruptive mutations in whole-exome sequence databases f

216 Pediatric patients with disruptive mutations present with autism, intellectual d

217 (p = 0.03) enrichment of de novo and private disruptive mutations within fetal CNS DNase I hypersensi

218 namics, while tolerating several potentially disruptive mutations.

219 erformance is essential to understanding the disruptive nature of pain and its variability between in

220 ional and structural connectivity due to the disruptive nature of the disease.

221 t as direct triggers of armed conflicts, the disruptive nature of these events seems to play out in e

222 Combined, these data support a role for disruptive NCKAP1 variants in neurodevelopmental delay/a

223 sed for capturing the underlying dynamics of disruptive neuronal responses across the brain in real-t

224 were used on Enhancing night during NREM; on Disruptive night, environmental sounds were used through

225 tended to Disrupt sleep administered on the "Disruptive" night increased momentary delta and slow-wav

226 on randomized counterbalanced Enhancing and Disruptive nights, with a preceding Habituation night (n

227 tions to inform investigators of potentially disruptive NM technologies that have to be investigated

228 and they are buffered against the effects of disruptive non-coding mutations.

229 N-terminal end of the kinase domain are more disruptive of protein function.

230 Here we develop a minimally disruptive optical approach to control protein tyrosine

231 iomyocyte-specific expression of an ion pore-disruptive Orai1(R91W) mutant (C-dnO1).

232 vo microdialysis experiments showed that the disruptive peptide selectively counteracted the ability

233 emonstrated that a cell-penetrating endosome-disruptive peptide we synthesized, termed 599, enhanced

234 ions that barely alter circuit behavior from disruptive perturbations that drastically disturb circui

235 tline several examples of zero-handling, non-disruptive protocols for detailing cell death mechanisms

236 mains an outstanding challenge for realizing disruptive quantum technology.

237 Our study provides insight into functionally disruptive, rare-variant mutations in human CaMKK2, whic

238 Molecular interrogation further reveals the disruptive reality that metastatic cancers are tremendou

239 mputation provides fertile opportunity for a disruptive reduction in the cost of biomedical imaging.

240 ngs demonstrate an enrichment of potentially disruptive regulatory noncoding DNVs in a fraction of CH

241 Heliconius melpomene and H. cydno are under disruptive selection due to increased predation of nonmi

242 llion-year history of alternating periods of disruptive selection in contrasting environments and adm

243 ur ecological diversity among consumers (via disruptive selection or plasticity).

244 pportunities for speciation during epochs of disruptive selection-a potential observable signature of

245 lternating between epochs of stabilizing and disruptive selection.

246 We find that disruptive sexual selection generates two fitness peaks

247 -regulation of thrombin-induced RhoA barrier disruptive signaling.

248 These disruptive sincRNAs can be unleashed by Pol II inhibitio

249 mber variant (CNV) or candidate de novo gene-disruptive single-nucleotide variant (SNV) had been dete

250 s but occurs by a shared mechanism involving disruptive SNPs in CTCF and transcription factor binding

251 increased allele switching at ASM loci, but disruptive SNPs in specific classes of CTCF and transcri

252 We find that interaction-disruptive SNVs are prevalent at both rare and common al

253 all three through recognition and then with disruptive solutions.

254 d in light of those stereotypes can elicit a disruptive state that undermines performance and aspirat

255 ative therapies, where the most advanced and disruptive strategies used for myocardial repair are dis

256 pability of pSiNP, could potentially offer a disruptive strategy to treat GBM.

257 ch a mechanism [12-14], direct evidence from disruptive studies has hitherto been lacking.

258 support for the formation of bulky, membrane-disruptive supramolecular amphiphiles due to "too strong

259 Disruptive systems (with negative MI) were activated by

260 port that single-dose radiotherapy (SDRT), a disruptive technique that ablates more than 90% of human

261 ve and label-free calorimetry could become a disruptive technique to study single cell metabolic heat

262 formulations of existing chemotherapies, and disruptive techniques.

263 with the ability to compete toe-to-toe with disruptive technologies like organic light-emitting diod

264 , rather, they have the potential to lead to disruptive technologies.

265 -dimensional (3D) printing, is a potentially disruptive technology across multiple industries, includ

266 Stem cell-derived human gametes, a disruptive technology in waiting, are likely to recapitu

267 Flow diversion is a disruptive technology that has changed the way many brai

268 reveals that treatment with biochar is less disruptive than activated carbon throughout metabolism.

269 , schizont-stage parasites were more barrier disruptive than trophozoite-stage P. falciparum-IE and p

270 Variants disruptive to CHD8 (which codes for the protein CHD8 [ch

271 using membrane-permeable agonists is equally disruptive to growth.

272 d, but usually through means that are highly disruptive to living cells and tissues.

273 ntain some dopaminergic tone and may be less disruptive to normal neuronal functions.

274 nourishment, and sleep is usually inherently disruptive to older patients regardless of the excellenc

275 r method shows that oxidative stress is more disruptive to organization and abundance of motifs in th

276 t the loss of betacyto-actin protein is more disruptive to primary fibroblast function than is the lo

277 rch more deeply into the past, are viewed as disruptive to science and technology and succeed further

278 s of widely used SDARs could be particularly disruptive to scientific research.

279 Yet, the presence of obstacles can be highly disruptive to the root system.

280 apy for hemophilia A that can potentially be disruptive to the way hemophilia is treated.

281 which is both life-sustaining and profoundly disruptive to their quality of life.

282 ensitive to environmental signals, including disruptive toxins, such as polybrominated diphenyl ether

283 rimary producers and predators were the most disruptive trophic groups of the exotic species.

284 %) had a pathogenic SNV and six (0.1%) had a disruptive variant that was expected to be pathogenic, w

285 melanoma risk in the general population are disruptive variants (R alleles) in the melanocortin 1 re

286 s by showing that they are enriched for rare disruptive variants and de novo variants from schizophre

287 xample of this challenge is the existence of disruptive variants in dosage-sensitive disease genes, e

288 esistant schizophrenia had an excess of rare disruptive variants in gene targets of antipsychotics (3

289 Disruptive variants in KMT2E are an under-recognized cau

290 The burden of singleton disruptive variants in the DISC1 Interactome was associa

291 WERacross), an increased burden of singleton disruptive variants in the Regulome was associated with

292 0 HX repeat sequences, including RERE, where disruptive variants in this motif have also been linked

293 may call out repetitively, sometimes called disruptive vocalisation, or verbal agitation.

294 hat could be avoided by using less circadian-disruptive wavelengths.

295 ic regime, we gain insight into the types of disruptive weather events that will become more prevalen

296 Invasive species can be particularly disruptive when they intersect with organisms of conserv

297 gher-impact work, with small teams known for disruptive work and large teams for developing work.

298 lance (OR, 3.97; 95% CI, 2.22 to 7.07), or a disruptive work environment (OR, 2.63; 95% CI, 1.48 to 4

299 areer satisfaction (73.2%); 44.7% reported a disruptive work environment and 35.4% reported depressiv

300 associated with poor work-life balance or a disruptive work environment-is warranted to develop targ

301 ber status in 2,988 cases of glioma revealed disruptive ZEB1 deletions associated with decreased surv