ライフサイエンスコーパス: dissect

1 regulatory role of the N-terminal domain was dissected.

2 ed, and its physiological role remains to be dissected.

3 oter analysis and expression variations were dissected.

4 Forty-four hemifaces from 25 cadavers were dissected.

5 We collected and dissected 121 individuals in 2013 and 2017, quantifying

6 Here, we dissect a four-species bacterial consortium sufficient f

7 We dissected a cardiac regeneration enhancer in zebrafish t

8 ssay, and cell-specific ablation methods, we dissected a neural circuit for prolonged itch formed as

9 approaches and analysis tools applicable to dissecting a broad range of both normal and perturbed ce

10 The hepatic pedicle vessels were dissected after division of the bile duct without a port

11 The results dissect and demonstrate that these signals control kerat

12 armonized approach is particularly useful to dissect and evaluate cell heterogeneity in complex syste

13 ic lines (NILs) can be used to characterize, dissect and validate QTL, but the development of NILs is

14 By applying pedigree analysis, we dissected and quantified the maintenance and inheritance

15 At the end of the study, the NAc was dissected and rt-qPCR methods were used to estimate CRF

16 rotein screening is a critical technique for dissecting and designing protein function.

17 gical macromolecules often prove critical to dissecting and understanding the precise mechanisms of a

18 were euthanized on-orbit, livers and spleens dissected, and remaining tissues frozen in situ for late

19 e multiaxial mechanical properties of murine dissecting aneurysm samples by combining in vitro extens

20 nd immunofluorescent approaches were used to dissect AnxA6(-/-) mice liver proliferation and energeti

21 ork analysis provides a noninvasive means of dissecting biological heterogeneity, yet its sensitivity

22 iation of silencing, and provides avenues to dissect broader evolutionary changes at FLC.

23 RNA sequencing technology, it is possible to dissect cell-type composition at high resolution.

24 kinases are thus much sought after, both for dissecting cell signaling pathways and for pharmaceutica

25 These results highlight the importance of dissecting cell-type-specific contributions to the disea

26 mic and genetic analyses provides a means to dissect cellular and functional diversity in the hypotha

27 real datasets demonstrate its capability of dissecting cellular heterogeneity within both transcript

28 and provide a chromatin roadmap for further dissecting cis regulation of cell fate in the intestine.

29 ere, using our chromatin mesoscale model, we dissect clutch patterns in fibers with different combina

30 By dissecting common pitfalls, we suggest how to better men

31 w insights for the cross-prediction concern, dissects complementarity between predictors and demonstr

32 Genetic screens are powerful tools to dissect complex biological processes, but a rate-limitin

33 l diversity among human populations; and (3) dissect complex phenotypes that arise from the actions o

34 a fully unsupervised deconvolution method to dissect complex tissues into molecularly distinctive tis

35 g (scRNA-seq) represents a powerful tool for dissecting complex multicellular behaviors in health and

36 quencing of dissociated mouse kidneys and of dissected cortex, outer, and inner medulla, to represent

37 study represents an unprecedented attempt in dissecting cross-communication pathways within one of th

38 oral development in Aquilegia at four finely dissected developmental stages, with eight biological re

39 a structurally identifiable kinetic model to dissect dual phosphorylation of ERK by MEK, a kinase tha

40 c interactions and, leveraging this ability, dissect epistatic interactions between cholesterol bioge

41 ted with expression throughout the genome by dissecting expression features to genes (eGene) and exon

42 xt-generation microRNA sequencing from micro-dissected formalin-fixed paraffin embedded melanomas and

43 expression analysis was performed on tissues dissected from cadaveric human eyes.

44 ell lines and individual nuclei from neurons dissected from the mouse brain.

45 ill likely complicate future work looking to dissect function or use associations for causal inferenc

46 nce from human bronchial epithelial cells to dissect functional genes/SNPs for asthma severity in the

47 tinib or venetoclax treatment, combined with dissecting functional interactions of Bcl-2 family membe

48 Dissecting functional metabolic differences between cell

49 To dissect functions of CTCF binding, we systematically ana

50 ed by several symptom criteria, which can be dissected further at the genetic level.

51 In dissecting further phosphoregulatory cell signals for CA

52 Moreover, RNA analyses of dissected grafts have not distinguished which hormone-sp

53 To assess and dissect hippocampal circuit function, we performed funct

54 Further, we dissect how combinations of MAPs affect motors and unvei

55 nderlying heterogeneity within monocytes and dissect how Lyn deficiency affects monocyte subset compo

56 l and cortical levels.SIGNIFICANCE STATEMENT Dissecting how auditory neurons discriminate communicati

57 Hence, by dissecting how different myeloid cells respond to cytoki

58 OXA9-mCherry knock-in reporter cell lines to dissect HOXA9 regulation.

59 ncing (scRNA-seq) provides an opportunity to dissect human disease pathophysiology at unprecedented r

60 Using glycan arrays, we dissected IgE responses to specific glycan moieties and

61 The growing role of biomaterials as tools to dissect immune function in fundamental and translational

62 This study establishes a tool for further dissecting immune surveillance against, and optimizing a

63 Here, we dissect in detail the properties of that actin organizat

64 ghlight the power of single-cell genomics in dissecting, in its many forms, intra-tumoral genetic het

65 Here, we dissected integrin-dependent signaling pathways involved

66 g the scale and resolution with which we can dissect interactions among animals.

67 the context of leveraging human genetics to dissect interactions in cellular and molecular pathways

68 Brains were dissected into frontal cortex, hippocampus, cerebellum,

69 luster assembly (ISC) machinery and has been dissected into three major steps: de novo synthesis of a

70 with distinct architecture and connectivity, dissecting its functional heterogeneity will provide key

71 We dissect key features, such as the network topology and f

72 iated with pathogenic TDP-43 deposition, and dissecting key molecular pathways through which TDP-43 m

73 We manually dissected kidney tubules from rat kidneys and subjected

74 l based on the assigned kinetic model and to dissect kinetic interaction parameters from single-molec

75 targeted experiments to analyze blood and to dissect lipid-signaling pathways such as in human platel

76 l then discuss new approaches that will help dissect M. tuberculosis immune evasion mechanisms and de

77 We micro-dissect malignant pulmonary nodules (MPNs) into paired p

78 Here, we further dissect mechanisms of RF clustering and transcription ac

79 eas and applying cutting-edge techniques, to dissect mechanisms underlying coronavirus disease-19 (CO

80 legans model will provide a key resource for dissecting mechanisms driving AD molecular pathology.

81 Dissecting mechanisms governing metastatic spread may un

82 ersity in tumors, but its application toward dissecting mechanisms underlying immune-modulating thera

83 Dissecting metabolic heterogeneity in AD pathogenesis ca

84 ach, CARP would be particularly suitable for dissecting miRNA regulatory networks in vivo.

85 ioned from cataloging this rich diversity to dissecting molecular mechanisms by which microbiomes inf

86 using context-specific responses that can be dissected molecularly and used for phenotypic benefit in

87 vestigate heterotypic cell communication, we dissected murine and human liver endothelial cell (EC) p

88 Here, we dissect natural variation in the behavioral flexibility

89 mouse olfactory epithelium cultures, in the dissected olfactory epithelium of rodents, and in live c

90 sically fluorescent pharmacological tool for dissecting OSBP properties at the cellular and molecular

91 Dissecting our recurrent neural network model revealed s

92 ants appear as powerful new tools to further dissect out the intersection of one-carbon metabolism wi

93 utting-edge technologies in animal models to dissect out the mechanisms by which early-life adversity

94 repared for LSFM could be rehydrated, the BM dissected out and reimaged at higher resolution with the

95 A new, tour de force study has dissected out the functional properties of identified me

96 mediation of hepatic iron overload has been dissected out.

97 receptor tyrosine kinases (RTKs) allows for dissecting out the receptor-specific signaling outcomes

98 Dissecting out their differential involvement will great

99 The challenge of dissecting pathological mechanisms underlying IBD has le

100 sented introduces a general NMR strategy for dissecting pathways of communication in homo-oligomeric

101 theoretical and computational framework for dissecting pattern formation in space and time, and reve

102 Organs and tumors were dissected, percentage injected dose per gram (%ID/g) was

103 Islets transplanted into a dissected peritoneal pouch show high efficiency to rever

104 g thylakoid topology lays the foundation for dissecting photosynthetic regulation at the level of sin

105 een the unavailability of methods capable of dissecting physiologically relevant B cell responses wit

106 the mRNA level, highlighting the utility of dissecting pQTL at peptide level resolution.

107 c stem cell (HSC) regulation is required for dissecting protective versus detrimental immunity to pat

108 udying endophenotypes it is possible to both dissect psychiatric disorders ('splitting') and to combi

109 nerated an atlas of open chromatin from nine dissected regions of the mid-gestation human telencephal

110 nvolved in membrane fusion/fission have been dissected, regulation of membrane dynamics remains poorl

111 skin topical exposure model for C. auris to dissect risk factors for colonization and to test interv

112 Here, we kinetically dissect Sec-dependent translocation by monitoring transl

113 To further dissect social behavior of Galphai2(-/-) mice, we perfor

114 control over organelle motility will aid in dissecting spatial cell biology and transport-related di

115 imens from 83 patients undergoing BCS and on dissected specimens from 7 patients undergoing mastectom

116 tility of caged, light-activated kinases for dissecting stress-activated signaling networks.

117 ignaling 4 (Rgs4) within laser-capture micro-dissected striatonigral (SN) and striatopallidal (SP) me

118 bin, the current work solves this problem by dissecting T-dependent HDX-MS profiles into contribution

119 for TEs are lacking, limiting our ability to dissect TE expression dynamics at single-cell resolution

120 on of TF IDRs, which provides a framework to dissect TF function in diseases associated with transcri

121 To dissect the activation mechanism, structural homology wa

122 To dissect the androgens potential impacts on these nAR-neg

123 alterations and gene expression changes, and dissect the associated molecular strategies.

124 g approaches, metabolic pathway analysis can dissect the basic functional modes of subsections of cor

125 Using an unbiased genetic approach, we dissect the basis of this divergent response to extracel

126 oscopy and molecular dynamics simulations to dissect the behavior of PRC2 on polynucleosome arrays.

127 mical, and advanced analytical techniques to dissect the biosynthetic pathway of mono- and dimethyl F

128 harmacological, and behavioral approaches to dissect the cell-type specific role of GluN2B, GluN2A, a

129 w niches and offers a systematic approach to dissect the complex organization of whole organs.

130 To accurately dissect the components of the early visual system respon

131 Here we dissect the contribution of local dynamics and inputs to

132 ndocrine cell differentiation strategies, we dissect the contribution of MAFB to beta-cell developmen

133 In this work, we dissect the contributions of modules within the disorder

134 To dissect the contributions of these cytosine modifying en

135 This novel assembly allowed us to dissect the effects of feeds and eyestalk ablation and r

136 ow next-generation experiments may precisely dissect the energetics of hybrid formation on the riboso

137 eq assays in Drosophila embryos were used to dissect the ERK-dependent control of the HMG-box repress

138 Here we functionally dissect the Erv46 subunit and define an approximately 60

139 To dissect the events leading to neoplasia, we used transmi

140 To systematically dissect the factors specifying each DNMT's activity, we

141 (2020) dissect the function of the enigmatic ventral pallidum a

142 we used a systematic mutagenesis strategy to dissect the functional anatomy of the CXCR4-CXCL12 compl

143 ased on the example of Arabidopsis PATL2, we dissect the functional domains for in vitro binding to p

144 The GUV-based approach will be useful to dissect the functions of essential coopted cellular fact

145 Therefore, our aim was to dissect the functions of extracellular ATP and P2Y(2) re

146 s novel GUV assay will be highly suitable to dissect the functions of viral and cellular factors in T

147 del we describe provides a system to further dissect the fundamental biological processes responsible

148 To dissect the GDNF-GFRalpha1-RET signaling complex, agents

149 ological advances provides an opportunity to dissect the genetic architecture of complex diseases at

150 ovide a valuable scaffold on which to better dissect the genetic control of plant shoot morphogenesis

151 PGMA clustering method found the best fit to dissect the genetic relationship in current set material

152 of cross-trait methods to multiomics data to dissect the heritability found in GWASs.

153 abolic depression dimension could be used to dissect the heterogeneity of depression and potentially

154 Multiplex spatial analyses dissect the heterogeneous cellular abundances and intera

155 d with T cell cloning and TCR sequencing, to dissect the human naive and memory CD4+ T cell repertoir

156 BPZE1.METHODSWe performed multiple assays to dissect the immune responses induced in humans (n = 12)

157 We applied spatially explicit tests to dissect the impacts of allele surfing, geographic isolat

158 Here, we dissect the interplay between (1) reading abilities, (2)

159 l experiments, theory and bioinformatics, we dissect the interplay between the DNA-binding domain of

160 In this Perspective, we quantitatively dissect the interplay between the two transport phenomen

161 ental strategies that are being leveraged to dissect the key cellular and molecular mechanisms that r

162 Altogether, these findings dissect the mechanism by which the FGF/FGFR system plays

163 To dissect the mechanism underlying flagellar rotational sw

164 served in the cold-resistant strain Ho_CR To dissect the mechanisms of Hydra aging, we compared the s

165 iated type 2 airway inflammation METHODS: To dissect the mechanisms of TSLP-mediated type 2 responses

166 ntegrative analyses have enabled new ways to dissect the mechanisms that imprint FLS, have helped to

167 Recent studies are beginning to dissect the mechanisms that make these MEK mutants hyper

168 We sought to dissect the mechanistic basis of liver redox variation a

169 Our data will help both to dissect the metabolic and developmental triggers for bol

170 To dissect the molecular basis for their activity, we deter

171 deleted (Mcub(-)(/-)) mice were generated to dissect the molecular function of this protein in the he

172 Using chemical kinetics we dissect the molecular mechanism of aggregation of indivi

173 DX-MS with mutagenesis and MD simulations to dissect the molecular mechanism of the prototypical tran

174 icity in maintaining immune homeostasis, and dissect the molecular mechanisms explaining the function

175 mal model of cholesterol crystal embolism to dissect the molecular mechanisms of cholesterol crystal

176 f patient mAbs provides a valuable method to dissect the molecular mechanisms within polyclonal popul

177 dissect the molecular pathways that respond to the state

178 ven analysis followed by linear modelling to dissect the molecular processes in strawberry postharves

179 Other experiments dissect the nature of that regulation of actin organizat

180 nference-based decision making and begins to dissect the network of brain regions crucial for its per

181 Here we used molecular genetics to dissect the neuronal circuits by which the ISR gates cog

182 s and metabolomics, have all been applied to dissect the pathogenesis of osteoporosis.

183 Collectively, LEI-301 may help to dissect the physiological role of the PLAATs.

184 w large-scale, wild-type approaches can help dissect the physiology of colonization versus infection,

185 To dissect the process of meiosis initiation, we investigat

186 ne in Drosophila embryos as a case study, we dissect the regulatory forces underpinning a key step al

187 To dissect the relationship between H3K79 methylation, cell

188 To further dissect the relationship between methionine catabolism a

189 e expression in different states of ESCs and dissect the relative contributions of mRNA-transcription

190 To dissect the role of epitope density in this process, we

191 vioral approaches in rodent model systems to dissect the role of Gadd45b in dopamine-dependent epigen

192 In this review, we dissect the role of galectins in shaping cellular circui

193 We dissect the role of N- and C-terminal flanking domains u

194 t this nematode could be a valuable model to dissect the role of protein mislipoylation and to develo

195 These results dissect the role of the miR-211-DUSP6-ERK5 axis in melan

196 harmacological inhibition of NMT1 to further dissect the role of this enzyme in cancer, and found an

197 rexpressing (TrkC-OE) mice were generated to dissect the role of TrkC in nephron development and main

198 Here, we dissect the role of Wnt ligands in the orientation of ha

199 Here, we attempt to dissect the roles of AtDRO1 by analyzing expression, pro

200 signaling, we applied genetic approaches to dissect the roles of caspase-8 in cell death and inflamm

201 To dissect the roles of metabolites, it is essential to und

202 mbly of viral replicase complexes (VRCs) and dissect the roles of various lipids and coopted host fac

203 In this issue of Cancer Cell, Gojo et al. dissect the single cell transcriptional landscapes of ep

204 In this work, we sought to dissect the spatiotemporal events involved in the biogen

205 Here we reconstitute and dissect the substrate specificity underpinning the cytop

206 We dissect the TASOR and MPP8 domains necessary for transge

207 le, unilateral ureteric obstruction model to dissect the transcriptomic landscape at the single-cell

208 ischemic stroke after recanalization and to dissect the underlying molecular thromboinflammatory mec

209 Here, we dissect the use of platelet RNA as a potential biomarker

210 iplinary structural/functional analyses that dissect the various states of the membrane fusion cascad

211 Using a series of mutations, we were able to dissect the VDR domain involved in the regulation of the

212 To understand the underlying cause, we dissected the behavior of individual components of the G

213 We dissected the cellular mechanisms controlling the basal

214 To elucidate this question, we dissected the circuit mechanisms underlying epileptogene

215 Moreover, we dissected the complex inverted haplotype of the MAPT (en

216 Here we dissected the contributions of the nonproteolytic and pr

217 Here, we dissected the distinct actions of Rab3-interacting molec

218 We computationally dissected the electronic and geometrical influences of o

219 We dissected the evolutionary mechanisms underlying these r

220 We dissected the excitatory synaptic connections in the som

221 In this study, we dissected the function and association between mtp53 and

222 Here we dissected the function of Brachypodium FT orthologs BdFT

223 es of interest in a bioinformatic screen, we dissected the function of these two genes in the control

224 We further dissected the functionality of this enhancer, finding a

225 RISPR/Cas9-mediated chromosomal deletion, we dissected the functions of these two regulatory elements

226 We also dissected the genome scale positive evolution and found

227 Here, we dissected the mechanism of miRNA dependency of the pesti

228 We dissected the mechanism of priority for these proteins a

229 omics, biochemical and imaging approach, we dissected the molecular events associated with the diffe

230 value of this highly consumed vegetable, we dissected the natural intraspecific variability of tococ

231 We dissected the particular contributions of sensory-driven

232 To understand this discrepancy, we dissected the physicochemical mechanism of the interacti

233 We dissected the regulatory dynamics of hunchback by the ac

234 that balance these disparate activities, we dissected the regulatory dynamics of UBE2S, a human APC/

235 In this study, we dissected the response of three TCR gammadelta cell subs

236 n overview of evolutionary studies that have dissected the role of conformational dynamics in facilit

237 We mechanistically dissected the TGF-beta family-driven regulation of Sca-1

238 Here we have dissected the unknown molecular steps of signaling-drive

239 Dissecting the basic mechanisms that coordinate cell fat

240 These findings establish a basis for dissecting the cellular and molecular crosstalk between

241 RT6 as a sensor of DSB, and pave the road to dissecting the contributions of distinct DSB sensors in

242 These findings are informative for dissecting the diverse functions of this poorly understo

243 Dissecting the function of B cells in the MS mouse model

244 ion protocol and a laboratory "tool kit" for dissecting the functions of Fzd subtypes in stem cell bi

245 Dissecting the genetic mechanism underlying a complex di

246 We argue that cataloging TE diversity and dissecting the idiosyncratic behavior of individual elem

247 Dissecting the interactions between WNV and host defense

248 rm a canonical SG and provide a platform for dissecting the interplay between the transcriptome and A

249 ell, but so far most studies have focused on dissecting the mechanism of action of individual miRNAs.

250 nues for studying mammalian pluripotency and dissecting the molecular mechanisms governing PGC specif

251 Dissecting the molecular mechanisms that allow local con

252 This sets a basis for dissecting the order and kinetics of chromatin-associate

253 g somatic cell reprogramming, as well as for dissecting the other biological functions of TET enzymat

254 A peritoneal pouch was formed by dissecting the parietal peritoneum from the transversali

255 the utility of yeast phospholipid mutants in dissecting the phospholipid requirements of ion channel

256 Dissecting the promoters physically contacted by these d

257 Our study generates a new resource for dissecting the regulatory mechanisms of appendage genera

258 These techniques have played a key role in dissecting the regulatory networks in gene expression in

259 Dissecting the relative contributions of simulations of

260 Such methodology holds promise for dissecting the replication cycle of many viruses.

261 gnotobiotic model systems has been vital to dissecting the role of the microbiome in host biology.

262 By dissecting the SG spatiotemporal proteomic landscape, we

263 DSSR (Dissecting the Spatial Structure of RNA) is an integrate

264 knowledge, which was developed by rationally dissecting the structural requirements for TLR7-targeted

265 Dissecting the subunit specificity of dynamics-decoding

266 es to specifically disrupt PNNs to precisely dissect their function.

267 effect of individual m(6)A modifications and dissect their functional roles.

268 , biochemical, and microscopic approaches to dissect their interplay in Schizosaccharomyces pombe.

269 naling patterns on "blank canvas" embryos to dissect their requirements.

270 us and with novel isoform-selective drugs to dissect their roles in LTD.

271 e heterogeneity of individual cell types and dissected their transitions and crosstalk during fibroge

272 Dissecting their precise evolution and cellular pathogen

273 rogradely labeled thalamocortical neurons to dissect these circuits.

274 says that have been used by investigators to dissect these features and that will hopefully lead to a

275 To dissect these inflammatory mechanisms, we developed cell

276 Here we attempt to dissect these influences by presenting either many or fe

277 To dissect this apparent discrepancy, we modulated LCN2 lev

278 RISPR-based screens can further functionally dissect this genetic regulatory architecture.

279 We here dissect this process using live imaging of the TSM1 axon

280 To dissect this process, we use micromanipulation to positi

281 tions has not been shown in vivo In order to dissect this regulatory network, we removed the complex

282 Dissecting this signal demonstrated that variants in clo

283 In this paper, freshly (non-fixed) dissected tissues obtained from breast cancer surgery we

284 erative diagnosis by scanning all around the dissected tissues.

285 119 Pf-infected Cambodian adults, with 5950 dissected to evaluate for transmitted infection.

286 cell RNA-sequencing (scRNA-seq) allows us to dissect transcriptional heterogeneity arising from cellu

287 e the clearance or malignancy involvement of dissected tumor margins by introducing two crucial class

288 Dissecting tumor heterogeneity is a key to understanding

289 y, an endeavor that highlighted the value of dissecting tumor immunity using large-scale methods.

290 bus and were further verified in six freshly dissected tumors from glioblastoma patients.

291 real-time diagnosis of suspicious margins of dissected tumors to declare more precise intraoperative

292 or therapeutic efforts, prompting efforts to dissect underlying mechanisms of expansion that may diff

293 The underlying mechanism was dissected using mice lacking DEL-1 or expressing a point

294 studying this birch mutant, we were able to dissect vertical proprioception from the gravitropic res

295 opose a computational method to quantify and dissect visual reasoning.

296 y of lesion morphology and damage within the dissected wall.

297 Dissecting white adipose tissue heterogeneity revealed t

298 ysis of Whole Genomes (PCAWG) Consortium, we dissect whole-genome sequencing data of over 2500 matche

299 A median of 21 nodes were dissected with 96% achieving an R0 resection.

300 lab to produce better future experiments by dissecting your past failures and successes and collabor