ライフサイエンスコーパス: dissociation constant

1 ator pKa (the negative logarithm of the acid dissociation constant).

2 yields KD=(2.1+/-1.1)muM as the single-site dissociation constant.

3 1-90), the weakest of which has a millimolar dissociation constant.

4 ds monoubiquitin with an unprecedented ~5 nM dissociation constant.

5 s) binds ssDNA containing N6mA, with a 10 nM dissociation constant.

6 form a one-to-one complex with a micromolar dissociation constant.

7 biology tools especially in determination of dissociation constants.

8 orms in distinct pockets with low millimolar dissociation constants.

9 te analogues of PNP bind with picomolar (pm) dissociation constants.

10 l relationship between these two equilibrium dissociation constants.

11 dent DNA intercalation rates and equilibrium dissociation constants.

12 acceptor fluorescence intensities, can yield dissociation constants.

13 llus kaustophilus with biologically relevant dissociation constants.

14 eral aptamers were discovered with nanomolar dissociation constants.

15 al arrangements yielded significantly higher dissociation constants.

16 t correlates surprisingly well with measured dissociation constants.

17 icients with their kinetic and thermodynamic dissociation constants.

18 o binding characteristics of (213)Bi-IMP288 (dissociation constant, 0.45 +/- 0.20 nM) to TF2-pretarge

19 lls were similar to those of (177)Lu-IMP288 (dissociation constant, 0.53 +/- 0.12 nM).

20 Results:(111)In-DTPA-anti-PD-L1 (dissociation constant, 0.6 +/- 0.1 nM) demonstrated incr

21 ndrial, and E. coli helix69 revealed similar dissociation constants (1.3-1.7 and 4.0-5.4 muM, respect

22 M forms a tight complex with the PHD of Akt (dissociation constant = 100 nm).

23 Thus, biotin, which has a dissociation constant 3 orders of magnitude higher than

24 Dissociation constant, 3.3 nM (+/-0.58), and receptor de

25 igal-3 tracer showed high affinity to gal-3 (dissociation constant, ~3.9 nM) and retained immunoreact

26 ate with the trends of nonheme-metal-binding dissociation constants (35, 22, and 9 muM) closely, sugg

27 ffinity for labeling of the administered GO (dissociation constant: 36.0 fM) and that the method's de

28 e 3) binds alpha-syn PFF with high affinity (dissociation constant = 77 nanomolar), whereas the alpha

29 y, thereby quantifying the alphabeta-tubulin dissociation constant (8.48 +/- 1.22 nM) and its tighten

30 reactivity on both platforms had the highest dissociation constant among the tested antibodies, sugge

31 ine starvation reduces SAM levels below this dissociation constant and promotes the association of SA

32 Here, we used ZX1, which has a 1 nM zinc dissociation constant and second-order rate constant for

33 otein complexes, allowing us to detect their dissociation constant and stoichiometry directly inside

34 Based on adsorption isotherms, we obtained dissociation constants and binding capacities of the mem

35 le-stranded RNAs bind to PKR with micromolar dissociation constants and can induce activation.

36 and the resulting equilibrium depends on the dissociation constants and concentration of all the spec

37 ence-based assay, we determined directly the dissociation constants and cooperativity of TPP binding

38 with surface plasmon resonance estimates of dissociation constants and FcRn affinity chromatography.

39 mal titration calorimetry, we determined the dissociation constants and ligand-to-protein stoichiomet

40 We confirmed the high-affinity dissociation constants and revealed a dependence of both

41 multaneously to quantitate binding kinetics, dissociation constants and thermodynamic energies.

42 by the substrate/product concentrations and dissociation constants, and can follow either a ping-pon

43 ffinity bidentate reagents, with equilibrium dissociation constants as low as 97 pM: >200-fold better

44 receptor (hGH-R) which displays an invariant dissociation constant at KD = 9 muM.

45 orms a tetragonal complex with a 34 +/- 5 fm dissociation constant at pH 7.4.

46 The dissociation constant between CEA protein and anti-CEA w

47 icles had very good affinity to cocaine with dissociation constants between 0.6nM and 5.3nM.

48 mples for two ELISA assays with low and high dissociation constant: biotin/streptavidin (10 fM) and H

49 ur approach combines pK(a) (logarithmic acid dissociation constant) calculations from all-atom consta

50 (1)H NMR studies revealed that the dissociation constant determined for these complexes was

51 makes weak binding (micromolar to millimolar dissociation constants) difficult to quantify under biol

52 the same binding site, leading up to a first dissociation constant even in the hundred nanomolar rang

53 at transition-state analogues with picomolar dissociation constants exhibit long lifetimes on their t

54 The dissociation constant for CysK:CdiA-CT (K d 11 nM) is co

55 itative binding experiments revealed a 9 mum dissociation constant for PirB-myelin-associated glycopr

56 n K44 is mutated to alanine, the equilibrium dissociation constant for small unilamellar vesicles inc

57 Additionally, the dissociation constant for the competitive inhibitor isop

58 The dissociation constant for this process was determined as

59 used to successfully measure an equilibrium dissociation constant for Zn(2+) and human serum albumin

60 l transitions are well described by stepwise dissociation constants for [Mg(2+)] (K1 = 328 +/- 30 muM

61 concentrations (above the Kd for Na(+)) the dissociation constants for aspartate were in the nanomol

62 Dissociation constants for different cation-bound comple

63 entrated protein solutions, with equilibrium dissociation constants for nonspecific protein-protein b

64 , we have used the TIMES signals to find the dissociation constants for the affinity of reactions, th

65 The dissociation constants for the enzyme.L-serine and enzym

66 roscale thermophoresis to directly determine dissociation constants for the I-D subunits from Synecho

67 H...pai interaction, which confers nanomolar dissociation constants for their respective ligands.

68 he substrate to kinetically characterize the dissociation constants for three-transition-state analog

69 te between ligands binding within a range of dissociation constants from K(d)=4 muM to K(d)=3.3 mM.

70 hibitory concentration (PSMA) of 15 nM and a dissociation constant (HSA) of 11.2 muM, cleared from th

71 To obtain the quintessential reaction dissociation constant, ideally measurements of reactions

72 trations 2 orders of magnitude below the ULD dissociation constant in mammalian cells.

73 .3 is calcium-dependent, with an equilibrium dissociation constant in the apo-state of 70 +/- 3 muM a

74 that zinc binds to this TDP-43 domain with a dissociation constant in the micromolar range and modifi

75 [(3)H]38 revealed a dissociation constant in the picomolar range (Kd 0.044 n

76 ested that enables determination of apparent dissociation constants in a single mass spectrometry exp

77 ace plasmon resonance to measure equilibrium dissociation constants in neurotransmitter membrane asso

78 lls via low-affinity anti-human IgE Abs with dissociation constants in the 10(-6) to 10(-8) M range.

79 microfluidic chip that allows measurement of dissociation constants in the micromolar-range.

80 Dissociation constants in the nanomolar regime were dete

81 n of M w with loading concentration revealed dissociation constants in the range 25-75 muM, commensur

82 yethylene glycol (PEG) chains with nanomolar dissociation constants in water.

83 nucleophiles (pKa < 25, where Ka is the acid dissociation constant) in palladium-catalysed asymmetric

84 acceptors, local protein concentrations, and dissociation constants, in each image pixel.

85 pairs in liquid ammonia, but the equilibrium dissociation constants indicate favorable interactions b

86 The result shows that the dissociation constant is 5.56 x 10(-10) M(-1).

87 impact is only noticeable if the multivalent dissociation constant is far below the virus concentrati

88 This behavior occurs when the Hill dissociation constant is near the mean odor concentratio

89 r metabolite, which had dopamine D3 receptor dissociation constant K (d) values of 320 and 210 nM, re

90 e sensors bind specifically to free Ub, have dissociation constant K(d) values down to 60 pM and, tog

91 current is used to determine the PSA-aptamer dissociation constant K(D), of ca. 2.6 nM.

92 e related free-energy barrier DeltaG and the dissociation constant K(D).

93 ording to the Hill equation, the equilibrium dissociation constant K(d)between PSA and its imprint wa

94 and VEGF, respectively, display equilibrium dissociation constants K(D) of ca. 1 pM, 1000-fold tight

95 gonist functional potency to its equilibrium dissociation constant (K(A)) at the active state of the

96 binders to this membrane protein, one with a dissociation constant (K(D) ) as low as 0.8 nm We furthe

97 Using MS, we determined the dissociation constant (K(d) ) for the SvWhiD-sigma(HrdB)

98 egion of OLE RNA, including stem P13, with a dissociation constant (K(D) ) of ~700 pm Analyses with m

99 ween 11-kDa and Grb2 that has an equilibrium dissociation constant (K(D) ) value of 18.13 nM.

100 Strongest binding, with an equilibrium dissociation constant (K(D) = 32 nM) close to values pre

101 emoval of the compound; 3) binds to tubulin [dissociation constant (K(d)) 0.4 +/- 0.1 muM] and inhibi

102 ide sensor binds strongly to the UlaG with a dissociation constant (K(d)) = 0.5 nM.

103 eap1) engages KEAP1 with nanomolar affinity (dissociation constant (K(d)) = 114 nM) and disrupts the

104 says were performed to determine equilibrium dissociation constant (K(d)) and half maximal inhibitory

105 In this real sample, the dissociation constant (K(d)) and hydrodynamic radius of

106 s, including the primary importance of a low dissociation constant (K(D)) and the extent to which thi

107 The peptide matrix lowered the dissociation constant (K(D)) by two orders of magnitude

108 Met-lead 1.44 M1 has an apparent dissociation constant (K(d)) of 25.97 nM, a detection li

109 vealed a high affinity toward glucose with a dissociation constant (K(d)) of 3 x 10(-8) M whereas the

110 tion rate constant (k(off)), and equilibrium dissociation constant (K(D)) of chemically distinct SERT

111 a selected fluorinated reporter ligand, the dissociation constant (K(D)) of other ligands of interes

112 ACTIS), a method for finding the equilibrium dissociation constant (K(d)) of protein-small-molecule c

113 be maintained with concentrations around the dissociation constant (K(d))(1-6) of the chemoreceptor.

114 Herein, dissociation constants (K(D) ) are investigated directly

115 are also provided, and an estimation of the dissociation constants (K(D)) between the SA receptors t

116 Equilibrium dissociation constants (K(d)) for each coagulation facto

117 ycan:bacterial-glycan pairs with equilibrium dissociation constants (K(D)) ranging between 100 nM and

118 okine occupancy, we determined intramembrane dissociation constants (K(d,2D)) of 180 and 480 receptor

119 binds to ATP with higher affinity than P2K1 (dissociation constant [K (d)] = 44.47 +/- 15.73 nm).

120 Zr]Zr-DFO-N-suc-muS110, targeting mouse CD3 (dissociation constant [K(D)], 2.9 nM) and mouse epitheli

121 A high inhibition potency (equilibrium dissociation constant [K(i)] = 2.34 +/- 2.94 nM on LNCaP

122 utward-facing conformations with low or high dissociation constant, K(D) , values for the conformatio

123 We probe the importance of the dissociation constant, K(D), and the concentration of DN

124 The molecular dissociation constant, K(d), is a well-established param

125 Herein, the apparent equilibrium dissociation constant, K(Dapp), between Cu(2+) and 1-pal

126 The apparent equilibrium dissociation constant, K(DApp), for the Cu(2+)-PE comple

127 ) was comparable to the substrate-inhibition dissociation constant, K(i)(HPA), determined previously.

128 BP4), bound to a 2.5-kb DNA with an apparent dissociation constant ($K_{\rm{D}}^{{\rm{app}}}$) of 150

129 for short) allows the estimation of the acid dissociation constant Ka(LAC) of diamagnetic transition

130 ), which correspond to acid-base equilibrium dissociation constants (Ka) in excellent agreement with

131 uantitative measurement of the submicromolar dissociation constant Kd (0.2 muM) of the complex betwee

132 y1Ac variants bind TnCAD with high affinity (dissociation constant Kd = 11-41 nM), kill TnCAD-express

133 ased fluorescent indicator, which displays a dissociation constant Kd = 3.1 mM suitable for the detec

134 ectively inhibit TNIK kinase activity with a dissociation constant Kd = ~1 muM.

135 loited to search for weak binders with large dissociation constants KD > 1 mM that are important for

136 s and fluorescence correlation spectroscopy (dissociation constants KD = 236 +/- 66 nM and KD = 282 +

137 es on ERK2, and we obtain an estimate of the dissociation constant (Kd ) for this interaction of 8 mu

138 C binds to the inner rod protein YscI with a dissociation constant (Kd ) of 3.8 mum and with 1:1 stoi

139 the soluble beta-1,3-glucan laminarin with a dissociation constant (Kd ) of approximately 26 mum and

140 rred interaction site close to heme 2 with a dissociation constant (Kd) = 490 muM, in good agreement

141 rmation of each heterooligomer has a similar dissociation constant (Kd) and free energy of associatio

142 Equilibrium dissociation constant (KD) and maximum binding capacity

143 Sensitivity of biosensors is set by the dissociation constant (Kd) between analytes and probes.

144 as identified as its membrane target and the dissociation constant (Kd) between Src and isorhamnetin

145 diate exosome endocytosis - with an apparent dissociation constant (Kd) equal to about 1 nM, indicati

146 cs, as indicated by the measured equilibrium dissociation constant (Kd) for the binding of free SDF1

147 Despite extensive measurements of TFs' dissociation constant (Kd) in vitro, their apparent Kdin

148 binds to beta3 integrin with an equilibrium dissociation constant (KD) of 21 microM, measured by sur

149 o isolate a urea specific DNA aptamer with a dissociation constant (Kd) of 232 nM.

150 The dissociation constant (KD) of a ligand of interest can b

151 binding affinity - is quantified through the dissociation constant (KD) of each recombinant antibody

152 The apparent dissociation constant (Kd) of Man-SNPs with fluorescein

153 Furthermore, we determined the dissociation constant (Kd) of ORF3 interactions with the

154 e innovated a single-molecule assay in which dissociation constant (Kd) of the conjugate can be separ

155 The dissociation constant (KD) of the interaction between re

156 observable was used to determine equilibrium dissociation constant (Kd) values.

157 The determined dissociation constant (Kd) was affected more than 50% wh

158 y was assessed using the occupancy plot; the dissociation constant (Kd) was determined by fitting sel

159 nable kinetics and a >150-fold change in the dissociation constant (Kd).

160 ed more than 20 synbodies with low nanomolar dissociation constants (KD < 10 nM) for GII.4 VLP.

161 ents revealed tight binding to McpX(PR) with dissociation constants (Kd ) in the nanomolar range for

162 entally measured bond lifetimes (1/koff) and dissociation constants (Kd = koff/kon), determined by me

163 n is a previously reported DNA aptamer, with dissociation constants (Kd values) of 0.6 muM.

164 ncentration, allowing determination of their dissociation constants (Kd's).

165 tely 10(-4)-10(-3) s(-1); giving equilibrium dissociation constants (Kd) = 8-50 nM.

166 es with over a four-log range of equilibrium dissociation constants (KD) and found that Simoa assay p

167 resolution binding curves from which precise dissociation constants (Kd) for protein-peptide interact

168 ary of 1.8 x 10(15) oligonucleotides showing dissociation constants (KD) in the low nanomolar range.

169 of R-LA in a biphasic binding isotherm with dissociation constants (Kd) of 0.9 and 7.4 mum.

170 GSK2801 binds to BAZ2 bromodomains with dissociation constants (KD) of 136 and 257 nM for BAZ2B

171 s 0.56mIU/ml and 2.93mIU/ml (at S/N=3), with dissociation constants (Kd) of 5.65+/-2.5mIU/ml and 7.28

172 tration devices were used to examine (i) the dissociation constants (Kd) of individual PFOS and PFOA

173 Aptamers with dissociation constants (Kd) of nanomolar range were isol

174 tailed study of specificity, interaction and dissociation constants (Kd) of the peptide-ligand Delta-

175 nd interactions, yet when applied to measure dissociation constants (KD) through ligand titration, th

176 eled Dynabeads exhibited similar equilibrium dissociation constants (Kd), approximately 2 nM.

177 Thus, the dissociation constants (Kd, muM) of 4 (11.2) and 5 (0.16

178 hat E4(x12)-Cy7 has a high-binding affinity (dissociation constant, Kd, 4.6 +/- 0.8 nM).

179 he concentration dependence of the effective dissociation constant, KD,eff, which varies from 100 pM

180 nce emission measurements of the equilibrium dissociation constants, Kd, of oxidized (hAR*NADP(+)) an

181 usable protein concentrations and accessible dissociation constants, KD.

182 The value of the equilibrium dissociation constant (KD1xKD2=1.64x10(-7) mol L(-1)) de

183 and specificity to both beta-LG A and B with dissociation constants (Kds) of 82 and 80nM, respectivel

184 The dissociation constants (Kds) of the selected DNA aptamer

185 ty was measured at pH 4.0 to 11.0 and its TA dissociation constant (Ki) at pH 7.0.

186 constituted serum mixture, its inhibitor-TTR dissociation constant (Ki) was used to estimate inhibiti

187 Association constant kon, dissociation constant koff, and binding potential (kon/k

188 Substrate dissociation constants (Ks) for four variants were 37-13

189 inhibitors 10 and chemical probe VH298, with dissociation constants <100 nM, which induced marked HIF

190 Dimer dissociation constants measured by a FRET-based assay ra

191 Counterintuitively, dissociation constant measurements show a stabilization

192 -saturation to estimate the tracer's in vivo dissociation constant, nondisplaceable volume of distrib

193 imum number of binding sites, as well as the dissociation constant of (3)H-prazosin and the inhibitio

194 d MIP sensor is characterized by an apparent dissociation constant of (3.3+/-0.5)x10(-9)M and has a b

195 bound to phosphorylated beta-catenin with a dissociation constant of 0.28 mum, and although both the

196 lized aptamer for thrombin was raised with a dissociation constant of 1.6 nM.

197 strongest binding to a hemagglutinin trimer (dissociation constant of 1.6 x 10(-7) M) and afforded th

198 Purified ELK1 and AR bound with a dissociation constant of 1.9 x 10(-8) m A purified mutan

199 ed using absorbance at 525 nm to determine a dissociation constant of 13 mum Steady-state oxygen cons

200 to phospholipids, particularly PIP2, with a dissociation constant of 17.64 nM.

201 ith a simple kinetic mass action model, a 2D dissociation constant of 1753 +/- 243 mum(-2) (correspon

202 an moiety of PSA with reasonable affinity (a dissociation constant of 177 +/- 65 nM).

203 (18)F-FHNP had a dissociation constant of 2 nM and maximum binding capaci

204 ensor which responds to beta-carotene with a dissociation constant of 2.2 muM.

205 against Mcl-1, resulting in a peptide with a dissociation constant of 2.9nM for binding to KSBcl-2 an

206 R2 interaction by binding to Sestrin2 with a dissociation constant of 20 micromolar, which is the leu

207 a (64)Cu-DOTA-anti-periostin-F(ab')2 with a dissociation constant of 29.2 +/- 3.0 nM.

208 A dissociation constant of 3 mum was estimated for a putat

209 of 18 fmol/10(6) cells, and (18)F-FES had a dissociation constant of 3 nM and maximum binding capaci

210 no acid residues of PRDM3 and PRDM16, with a dissociation constant of 3.0 muM, as measured by isother

211 NSAH binds to hRRM1 with an apparent dissociation constant of 37 microM, and steady-state kin

212 S, and we estimated an hsc-70/PS equilibrium dissociation constant of 4.7 +/- 0.1 mum.

213 he highest binding affinity to BTX-2, with a dissociation constant of 42nM.

214 ctin domain of LecRK-I.8 binds NAD(+) with a dissociation constant of 436.5 +/- 104.8 nM, although mu

215 F-FPyKYNE-losartan bound with high affinity (dissociation constant of 49.4 +/- 18.0 nM and maximal bi

216 ditions used for biochemical analysis with a dissociation constant of 5 nM, but the pro-domain can be

217 and design strategy, crisp-17 offers a Cu(I) dissociation constant of 8 aM, thus exceeding the bindin

218 TPX2 bound to microtubules with an apparent dissociation constant of approximately 200 nm, and micro

219 The final aptamer has a dissociation constant of approximately 35 nM.

220 complex by binding directly to SAMTOR with a dissociation constant of approximately 7 muM.

221 ave substantial reduction in the equilibrium dissociation constant of binding (KD) of hMPG toward 1,N

222 The dissociation constant of carbonylated recombinant MyBPC

223 oichiometry, copper oxidation state, and the dissociation constant of human amylin-copper(II) complex

224 A TTR/Abeta(1-42) (1:1) complex with a dissociation constant of K(d) = 0.94 muM is formed; with

225 is of the monomer/dimer equilibria reveals a dissociation constant of K(d) =0.14+/-0.03 muM, indicati

226 s a sequence-specific PNA-RNA triplex with a dissociation constant of less than 1 nm at physiological

227 2 bound to human and cynomolgus PD-L1 with a dissociation constant of less than 35 pM, as measured by

228 iated with the partition coefficient and the dissociation constant of the acid, as well as to the con

229 The dissociation constant of the best aptamer, designated as

230 A fit to the law of mass action reveals the dissociation constant of the binding reaction.

231 The equilibrium dissociation constant of the dimeric clamp varies with s

232 e, must be at least 19 times higher than the dissociation constant of the higher affinity of its two

233 The dissociation constant of the IFT46-ODA16 complex was 200

234 mm THF at pH 7.5, respectively), and the THF dissociation constant of the WT was also 3-fold lower th

235 The HPA dissociation constant of TK(low) was comparable to the s

236 le side chains of the repeat segment, with a dissociation constant of ~1.2 mM, and promotes an N-term

237 to the resting hERG channel with an apparent dissociation constant of ~1.4 muM, and inhibits hERG cur

238 ming a PS-Zn(2+) complex with an equilibrium dissociation constant of ~100 muM.

239 1753 +/- 243 mum(-2) (corresponding to a 3D dissociation constant of ~30 muM) was obtained for the b

240 -GATOR2 complex by binding to CASTOR1 with a dissociation constant of ~30 muM, and its arginine-bindi

241 d to directly and simultaneously measure the dissociation constants of 11 PFASs to an enzyme, which w

242 from 3 to 31 min for seven Immucillins with dissociation constants of 115 to 6 pm Treatment of human

243 The affinity analyses provided dissociation constants of 2.3 x 10(-10) M and 3 x 10(-11

244 pair of Ca(2+) binding sites with identical dissociation constants of 5.03 muM, (ii) a Ca(2+)-depend

245 ition-state analogues of H. pylori MTAN with dissociation constants of 50 pM or below.

246 The dissociation constants of albumin-binding of our lipidat

247 We have determined the dissociation constants of binding between the lipidated

248 peptide sequences for which the experimental dissociation constants of binding to the well-characteri

249 receptors in vitro (~15 nM), as well as the dissociation constants of bTC-Cbl ( K(d) = 13 nM) and RA

250 Fos and c-Jun, which allowed us to determine dissociation constants of c-Fos homodimers (Kd = 6.7 +/-

251 tochastic analysis was used to determine the dissociation constants of CPR/CYP2C9 complexes in a lipi

252 Dissociation constants of GG-X-GG and X5 peptides (X = G

253 udy, the effect of the ionic strength on the dissociation constants of six different noncovalent comp

254 r lipids can be characterized by equilibrium dissociation constants of tens of micromolar.

255 thoxy)cinnamoyl]-1,5-gamma-quinide), finding dissociation constants of the albumin-chlorogenic acids

256 Because the dissociation constants of the dimer and tetramer are ver

257 itration studies allowed us to determine the dissociation constants of the four binding sites with va

258 in the upstream regulator are far below the dissociation constants of the regulated genes, as with i

259 raction was selected taking into account the dissociation constants of these arsenic species in diffe

260 an be used for the accurate determination of dissociation constants of weak protein-ligand complexes.

261 with 1:1 stoichiometry at a KD (equilibrium dissociation constant) of 1.5 muM.

262 s the scFv antibody with a K(D) (equilibrium dissociation constant) of 46 nM.

263 mon resonance (SPR) to determine the binding dissociation constant (off-rate, kd) for compounds bindi

264 The low value of equilibrium dissociation constant or affinity unit (KD) showed high

265 pH than His37 in AM2, indicating larger acid-dissociation constants or lower pKa's.

266 Dissociation constants (p K(a)) and log P values for 2,2

267 ures suggest that Lys73 has a perturbed acid dissociation constant (pK(a)) compared with acyl-enzyme

268 asic covariates, like lipophilicity (log P), dissociation constant (pK(a)), and polar surface area (P

269 The proton-dissociation constants (pK(a)'s) of H19 in BM2 were foun

270 Dissociation constants (pK(a)) and log P values were mea

271 d by volume ratios, we use the apparent acid dissociation constant, pK', as a proxy for intersystem c

272 y, theoretical results indicate aqueous acid dissociation constant (pKa) values of 1.5 +/- 1 for NH3C

273 15)N intensities yielded two resolved proton dissociation constants (pKa's) of 7.1 and 5.4, which dif

274 protonation of carboxyl groups with low acid dissociation constants (pKa) as the main contributors to

275 ders specific to carbonic anhydrase II, with dissociation constants ranging between 6 muM and 14 nM.

276 d affinities for 19 individual peptides with dissociation constants ranging from 0.1 to 60nM.

277 an array of aptamer switches with effective dissociation constants ranging from 10 muM to 40 mM and

278 logically relevant thermodynamic affinities (dissociation constants ranging from 700 nM for Mn(II) to

279 his spectrum, as characterized by millimolar dissociation constants, relies on a handful of cases in

280 zine fluorescent K(+) sensor (KNIR-1) with a dissociation constant suited for detecting changes in in

281 CPR(ox)/CYP2C9 complexes have a much higher dissociation constant than CPR(2-)/CYP2C9 or CPR(4-)/CYP

282 s forms of DNA bind to TNFalpha with low mum dissociation constants, the interaction stabilizes the t

283 ovel tandem tetramers bound with a nanomolar dissociation constant to 24 bp sequences made up of four

284 The Fab (BRG) binds with 20nM dissociation constant to a single-stranded RNA (ssRNA) s

285 The dissociation constant to produce free ions in toluene by

286 s with duplexed DNA substrates; the apparent dissociation constants to well-matched and damaged duple

287 sub-nanomolar (0.69 nM) apparent equilibrium dissociation constant toward the extracellular domain of

288 e fully optimized by quantification of their dissociation constants, tuning the stoichiometric ratios

289 igands and that it binds a fatty acid with a dissociation constant typical of lipid transporter prote

290 For the peptide Tyr-Leu-Ala, the equilibrium dissociation constant value is 7.2 nM, whereas that of i

291 The dissociation constant value was 387.7 +/- 97.9 nM for Cy

292 series of affinity mutants was selected with dissociation constant values of 0.08 to 11 mm, which spa

293 raction was 0.2%; thus, the tracer's in vivo dissociation constant was estimated to be 55 pM.

294 ximum number of binding sites x affinity [(1/dissociation constant]) was determined using in vitro ho

295 affinity Cu(I) chelator with low zeptomolar dissociation constant, we utilized the endothelial cance

296 ty of the method for subsequent analysis and dissociation constants were calculated as 3.24-5.24x10(-

297 ive neurotransmitters, from which adsorption dissociation constants were calculated, spanning from 5.

298 ectrometry and a label-free assay from which dissociation constants were calculated.

299 in to 11CR and opsin has a 25-pM equilibrium dissociation constant, which corresponds to only 0.3 kca

300 t M1 (A213) exhibits an almost twofold lower dissociation constant with its primary target human neut