ライフサイエンスコーパス: dissociation inhibitor

1 her on membranes or in cytosol, bound to GDP dissociation inhibitor.

2 Ig-like domain of the Rho guanine nucleotide dissociation inhibitor.

3 interaction with the Rho guanine nucleotide dissociation inhibitor.

4 ng protein and ARF domains, may act as a GDP dissociation inhibitor.

5 is a highly conserved Ran guanine nucleotide dissociation inhibitor.

6 d through Rdi1, the Cdc42 guanine nucleotide dissociation inhibitor.

7 1-20 membranes remained sensitive to Rab GDP dissociation inhibitor.

8 ultured cells is not associated with Rab GDP dissociation inhibitors.

9 inal domains of the guanosine 5'-diphosphate dissociation inhibitors.

10 ion of Galphai, acting as guanine nucleotide dissociation inhibitors.

11 nding protein (FUS) with rs1538664A, Rho GDP dissociation inhibitor 1 (ARHDGIA) with rs479200T and hy

12 lation of Rab1 disrupts interaction with GDP dissociation inhibitor 1 (GDI1), but not guanine exchang

13 8 integrin coimmunoprecipitates with Rho-GDP dissociation inhibitor 1 (RhoGDI1), an intracellular sig

14 ily GTPase regulator, Rho guanine nucleotide dissociation inhibitor 1 (RhoGDI1), can interact with ep

15 e first small-molecule ligand of the RHO GDP-dissociation inhibitor 1 (RHOGDI1), termed Rhonin.

16 zation and phosphorylation status of Rho GDP dissociation inhibitor 1 (RhoGDI1).

17 eta8 interaction with Rho guanine nucleotide dissociation inhibitor-1 (GDI).

18 , vimentin), only antibodies against Rho GDP-dissociation inhibitor 2 (ARHGDIB) (adjusted MFI [aMFI]>

19 B7A and the Rab regulator guanine nucleotide dissociation inhibitor 2 (GDI2).

20 Rho GDP dissociation inhibitor 2 (RhoGDI2) has been identified a

21 A reduction in Rho GDP Dissociation Inhibitor 2 (RhoGDI2) protein has been asso

22 hibitor of Rho proteins known as the Rho-GDP dissociation inhibitor 2 (RhoGDI2).

23 Low expression of RhoGTP dissociation inhibitor 2 (RhoGDI2; also known as ARHGDIB

24 plasma membrane-associated protein, Rho GDP-dissociation inhibitor 2 [ARHGDIB], Rho guanine nucleoti

25 Rho1-GDP in vitro and that Msb3 and Rho GDP dissociation inhibitor act independently but oppositely

26 -amino-acid sequence with guanine nucleotide dissociation inhibitor activity against G-alpha subunits

27 s through its two GoLoco motifs to exert GDP dissociation inhibitor activity over Galpha(i) subunits;

28 g domains, and a GoLoco motif, which has GDP dissociation inhibitor activity.

29 Here, the Rho guanine dissociation inhibitor alpha (RhoGDIalpha) is identified

30 Previous studies revealed that Rho GDP-dissociation inhibitor alpha (RhoGDIalpha) is involved i

31 cell survival and proliferation, and Rho GDP dissociation inhibitor alpha (RhoGDIalpha), a member of

32 ycle regulated by the Rho guanine nucleotide dissociation inhibitor alpha (RhoGDIalpha).

33 sed probe revealed Sec23 homologue A and GDP-dissociation inhibitor alpha as potential targets implic

34 subunit/DJ-1 PARK7) and RhoGDIalpha (Rho GDP-dissociation inhibitor alpha).

35 The Rab-specific alphaGDP-dissociation inhibitor (alphaGDI) regulates the recyclin

36 es suggest that PCP2 is a guanine nucleotide dissociation inhibitor, although a guanine nucleotide ex

37 2 (PCP2), a member of the family of guanine dissociation inhibitors and a strong interactor with the

38 of Gbetagamma signaling pathways, act as GDP dissociation inhibitors and negatively regulate the acti

39 between RhoA and Rho-GDI (guanine nucleotide dissociation inhibitor) and promotes the membrane transl

40 l proteins (also known as guanine nucleotide dissociation inhibitors) and, thus, they become trapped

41 in signaling 3 (AGS3, its guanine nucleotide dissociation inhibitor), and GIV determines whether auto

42 substrates poly(ADP-ribose) polymerase, GDP dissociation inhibitor, and PKCdelta was observed when P

43 factors (GEF); group II, guanine nucleotide dissociation inhibitors; and group III, entities that bi

44 ion inhibitors Nme1, Nme2, and Nme3, the GDP dissociation inhibitor Arhgdib, and the metalloprotease

45 itro but promoted binding to the Rho guanine-dissociation inhibitor as measured by exchange factor co

46 DPC localization of CD43 and RhoGDP dissociation inhibitor, as well as the novel DPC protein

47 We demonstrate that modification of Rab GDP-Dissociation Inhibitor Beta (GDI2) by ISG15 (ISGylation)

48 ncluding beta-lactate dehydrogenase, Rho GDP dissociation inhibitor beta, ATP synthase, elongation fa

49 RC1), by its direct association with Rab GDP dissociation inhibitor beta, which likely regulates RHEB

50 and functions as a Gsp1p guanine nucleotide dissociation inhibitor by reducing the activity of Prp20

51 inding proteins of the rab family by rab GDP dissociation inhibitor completely abolishes formation of

52 s further investigation to clarify how a GDP-dissociation inhibitor could potently inhibit these onco

53 The Rho GDP dissociation inhibitor D4-GDI is overexpressed in some h

54 ibition of Pak1 kinase activity and Rac1-GDP-dissociation inhibitor disassociation, and inhibition of

55 membranes functions as a guanine nucleotide dissociation inhibitor displacement factor.

56 PR peptide functions as a guanine nucleotide dissociation inhibitor for Gialpha.

57 Galpha(GDP) and acts as a guanine nucleotide dissociation inhibitor for heterotrimeric G-proteins.

58 osol, and this effect was blocked by the GDP dissociation inhibitor for Rho (Rho-GDI).

59 ing Rho GDIalpha, an endogenous specific GDP dissociation inhibitor for Rho family proteins, using th

60 d by expressing Rho GDIalpha, a specific GDP dissociation inhibitor for Rho family proteins, using th

61 t D4-GDI, an abundant hematopoietic cell GDP dissociation inhibitor for the Ras-related Rho family GT

62 poly(ADP ribose) polymerase and D4-GDI (GDP dissociation inhibitor for the rho family), as well as t

63 RhoGDI, a guanine-nucleotide dissociation inhibitor for the Rho family, inhibits phos

64 ins as nucleotide exchange factors or as GDP dissociation inhibitors for Galpha have been proposed.

65 lts suggest that GPR proteins are potent GDP dissociation inhibitors for Gialpha-like Galpha subunits

66 i.e. G betagamma, AGS3 (a guanine nucleotide dissociation inhibitor), GAIP/RGS19 (a GTPase-activating

67 i) signals because of the guanine nucleotide dissociation inhibitor (GDI) activity of a GoLoco motif

68 ays, both regions exhibit guanine nucleotide dissociation inhibitor (GDI) activity, inhibiting the ra

69 unctionally mimics a host guanine nucleotide dissociation inhibitor (GDI) by contacting key residues

70 are kept soluble in the cytoplasm by the GDP dissociation inhibitor (GDI) chaperone.

71 exchange factor (GEF, Mon1-Ccz1), a Rab-GDP dissociation inhibitor (GDI) complex (prenylated Ypt7-GD

72 The Rho-GDP guanine nucleotide dissociation inhibitor (GDI) complexes with the GDP-boun

73 idue conserved domain that acts as a guanine dissociation inhibitor (GDI) for G(i/o)(alpha) subunits.

74 B1 is a calcium-dependent guanine nucleotide dissociation inhibitor (GDI) for Galpha(i1).

75 proteins; it serves as a guanine nucleotide dissociation inhibitor (GDI) for Galphas using the same

76 Gialpha and Goalphaand a guanine nucleotide dissociation inhibitor (GDI) for Gialpha.

77 th GTPase-accelerating protein (GAP) and GDP dissociation inhibitor (GDI) functions, and eIF2B is the

78 TrkBT1 interacted with Rho GDP dissociation inhibitor (GDI) in vivo, but Flag-TrkBT1Del

79 Guanine nucleotide dissociation inhibitor (GDI) is an essential protein req

80 Rab-GDP dissociation inhibitor (GDI) is an important modulator o

81 and GTP hydrolysis on Cdc42Hs by the Rho GDP-dissociation inhibitor (GDI) is extremely sensitive to c

82 on, was perturbed by modest increases in GDP dissociation inhibitor (GDI) levels.

83 hannels are subject to regulation by guanine dissociation inhibitor (GDI) proteins like LGN, a mammal

84 haromyces cerevisiae, the guanine nucleotide dissociation inhibitor (GDI) Rdi1 recycles Cdc42 through

85 Guanine nucleotide dissociation inhibitor (GDI) regulates the recycling of

86 The GDP dissociation inhibitor (GDI) solubilizes prenylated Rab

87 mediated by interaction with the protein GDP dissociation inhibitor (GDI) that binds to prenylated in

88 n signaling 3 (AGS3) is a guanine nucleotide dissociation inhibitor (GDI) that contains four G protei

89 h its RGS domain and as a guanine nucleotide dissociation inhibitor (GDI) through its GoLoco motif.

90 Guanine nucleotide dissociation inhibitor (GDI), a protein that extracts Ra

91 AGS3, a guanine nucleotide dissociation inhibitor (GDI), binds and stabilizes Galph

92 aS binding assays, AGS3 behaves as a guanine dissociation inhibitor (GDI), inhibiting the rate of exc

93 Rdi1, a guanine nucleotide dissociation inhibitor (GDI), mediates a fast recycling

94 itory exchange factor Rho-guanine nucleotide dissociation inhibitor (GDI), or Clostridium botulinum C

95 Membrane-bound GDP-Rabs interact with GDP dissociation inhibitor (GDI), resulting in the dissociat

96 cture of the bovine alpha-isoform of Rab GDP-dissociation inhibitor (GDI), which functions in vesicle

97 reported to function as a guanine nucleotide dissociation inhibitor (GDI), which inhibits Cdc42 activ

98 Rush also directly binds to Rab GDP dissociation inhibitor (Gdi), which is involved in the a

99 for Rab localization and function is Rab GDP dissociation inhibitor (GDI), which is proposed to recyc

100 Guanosine nucleotide dissociation inhibitor (GDI), which regulates the cycle

101 rane localization and the guanine-nucleotide dissociation inhibitor (GDI)-like domain of YopO coopera

102 ence variability in their guanine nucleotide dissociation inhibitor (GDI)-like domains, and demonstra

103 c Cdc42 recycling through Guanine nucleotide Dissociation Inhibitor (GDI)-mediated membrane extractio

104 Galpha(i1) and acts as a guanine nucleotide dissociation inhibitor (GDI).

105 complexed with its cytosolic chaperone, GDP dissociation inhibitor (GDI).

106 ions bound to a cytosolic protein termed GDP-dissociation inhibitor (GDI).

107 e a bi-functional protein that acts as a GDP dissociation inhibitor (GDI).

108 maintained in the cytosol by binding to GDP-dissociation inhibitor (GDI).

109 essed with or without Rho-guanine nucleotide dissociation inhibitor (GDI)alpha.

110 e each flanked by genes encoding Rho guanine-dissociation inhibitors (GDI), known regulators of RhoGT

111 heir function appears to be regulated by GDP-dissociation inhibitors (GDI), three of which have been

112 The GDP-dissociation-inhibitor (GDI) for Rho-like GTP-binding pr

113 requires the REP-related guanine-nucleotide-dissociation-inhibitor (GDI).

114 hat regulate the Rab GTPase cycle-Gdi1p (GDP-dissociation inhibitor [GDI]) or Gyp1p/Gyp7p (GTPase-act

115 Guanosine diphosphate (GDP)-dissociation inhibitors (GDIs) belong to one of three cl

116 Guanine nucleotide dissociation inhibitors (GDIs) bind and sequester GTPase

117 present a novel family of guanine nucleotide dissociation inhibitors (GDIs) for G(alpha) subunits fro

118 SESN proteins function as guanine nucleotide dissociation inhibitors (GDIs) for RAGA/B, and interact

119 GTPases, and function as guanine nucleotide dissociation inhibitors (GDIs) for RagA/B.

120 The Rho GDP-dissociation inhibitors (GDIs) negatively regulate Rho-f

121 domain that mimics host guanidine nucleotide dissociation inhibitors (GDIs) of the Rho GTPases.

122 GDP-dissociation inhibitors (GDIs) play a primary role in mo

123 GDP-dissociation inhibitors (GDIs) play a primary role in mo

124 The GDP dissociation inhibitors (GDIs) represent an important cl

125 gulators of Rho proteins, guanine nucleotide dissociation inhibitors (GDIs), form a complex with the

126 s, Gbetagamma, effectors, guanine nucleotide dissociation inhibitors (GDIs), GTPase-activating protei

127 Guanosine diphosphate (GDP) dissociation inhibitors (GDIs), such as activators of G

128 aled a motif conserved in guanine nucleotide dissociation inhibitors (GDIs), which suggested a novel

129 Rho and Rab subfamilies, guanine nucleotide dissociation inhibitors (GDIs).

130 ity to regulatory proteins including Rab GDP dissociation inhibitors (GDIs).

131 fails to form detectable complexes with GDP-dissociation inhibitors (GDIs).

132 ting proteins (GAPs), and guanine nucleotide dissociation inhibitors (GDIs).

133 ting proteins (GAPs), and guanine nucleotide dissociation inhibitors (GDIs).

134 rred by binding of Rac to guanine-nucleotide dissociation inhibitors (GDIs).

135 Moreover, a Rab guanine nucleotide dissociation inhibitor has been shown to cause Rab3A to

136 uclein on synaptic vesicles and that the GDP dissociation inhibitor.Hsp90 complex that controls Rab3a

137 o demonstrated modulatory roles for Rac1/GDP dissociation inhibitor in glucose-stimulated insulin sec

138 maleimide and recombinant bovine Rab-guanine dissociation inhibitor inhibited beta-lactamase secretio

139 Purified GDP-dissociation inhibitor inhibited homotypic lysosome fusi

140 hat this occurs through enhanced Rho guanine-dissociation inhibitor interaction rather than direct pe

141 Like Rab guanine nucleotide dissociation inhibitor, it forms a 1:1 complex with Rab3

142 otein binding region of Cavce possesses "GDP dissociation inhibitor-like activity" with the same pote

143 ere, we report that FeoB harbors a novel GDP dissociation inhibitor-like domain that specifically sta

144 CARD9 associated with the GDP-dissociation inhibitor LyGDI in phagosomes after bacteri

145 complex I, or of gdi-1, a guanine nucleotide dissociation inhibitor, may act in combination with defe

146 the capacity of Rab9 for guanine nucleotide dissociation inhibitor-mediated extraction from Niemann-

147 from the PM, in a process reminiscent of GDP dissociation inhibitor-mediated membrane recycling of Ra

148 hat does not depend on GTP hydrolysis or GDP dissociation inhibitor-mediated recycling.

149 ent Rab3a mutant, by a dominant-negative GDP dissociation inhibitor mutant unable to recycle Rab3a of

150 rmally analogous to the action of nucleotide dissociation inhibitors (NDI or GDI) for regulatory GTPa

151 differs from that of Rab guanine nucleotide dissociation inhibitor not only in being Ca2+-dependent

152 c42-guanosine diphosphate (GDP) from Rho GDP dissociation inhibitor or for the membrane recruitment o

153 ed by deletion of Rdi1, a guanine nucleotide dissociation inhibitor, or Bnr1, a formin, but was compl

154 asma membrane and were suppressed by guanine dissociation inhibitor overexpression, which removed ect

155 oid compounds and the Rho-guanine nucleotide dissociation inhibitor predicted by computational thread

156 us Cdc42 from Golgi membranes by the Rho-GDP dissociation inhibitor protein fails to solubilize IQGAP

157 Ran also interacts with a guanine nucleotide dissociation inhibitor, RanBP1.

158 by displacing it from its cognate guanosine dissociation inhibitor, resulting in the stimulation of

159 rphogenesis, we overexpressed bovine Rho GDP dissociation inhibitor (Rho GDI alpha), which serves as

160 nd identified RDI1, a Rho guanine nucleotide dissociation inhibitor (Rho GDI), as a positive regulato

161 ase 5 and consequent dissociation of Rho GDP dissociation inhibitor (Rho-GDI) from an ezrin/Rho-GDI c

162 Pases activity, by overexpression of Rho GDP dissociation inhibitor (Rho-GDI), inhibited the strain-i

163 Rho-GDP dissociation inhibitors (Rho-GDI) are repressors of Rho-

164 The guanine nucleotide dissociation inhibitor RhoGDI co-precipitates with RhoA,

165 The guanine dissociation inhibitor RhoGDI consists of a folded C-ter

166 ily in the cytoplasm, bound to the guanosine dissociation inhibitor RhoGDI.

167 The guanine dissociation inhibitors RhoGDI and D4GDI inhibit guanosi

168 Rac1 and two known binding partners, Rho GDP dissociation inhibitor (RhoGDI) and p21-activated kinase

169 we found that Rac1 dissociates from Rho GDP dissociation inhibitor (RhoGDI) and translocates to the

170 f both RhoA and Rac1; an increase in Rho GDP-dissociation inhibitor (RhoGDI) binding in the absence o

171 The Rho GDP dissociation inhibitor (RhoGDI) can bind to small GTPase

172 We have investigated the effects of Rho GDP dissociation inhibitor (RhoGDI) on exocytosis induced by

173 The Rho guanine nucleotide dissociation inhibitor (RhoGDI) plays a key regulatory r

174 Rho GDP dissociation inhibitor (RhoGDI) plays an essential role

175 SCN1 and showed that SCN1 is a RhoGTPase GDP dissociation inhibitor (RhoGDI) that spatially restricts

176 anisms underlying the ability of the Rho-GDP dissociation inhibitor (RhoGDI) to elicit the release of

177 depends on its interaction with the Rho GDP dissociation inhibitor (RhoGDI) via the XIAP RING domain

178 Using this screen, Rho guanine dissociation inhibitor (RhoGDI) was identified as a pote

179 egative regulator the Rho guanine nucleotide dissociation inhibitor (RhoGDI), an interaction that is

180 ng of the Rho GTPases is mediated by Rho GDP dissociation inhibitor (RhoGDI), which forms a stable co

181 e a common inhibitor, Rho guanine nucleotide dissociation inhibitor (RhoGDI), which regulates their e

182 in the interaction of Cdc42 with the Rho-GDP dissociation inhibitor (RhoGDI).

183 1 with its inhibitor, Rho guanine nucleotide dissociation inhibitor (RhoGDI).

184 tly shown that reduced expression of the GDP dissociation inhibitor, RhoGDI2, is associated with decr

185 the transgenic overexpression of the Rho GDP dissociation inhibitor RhoGDIalpha.

186 tile anesthetic, halothane, with the Rho GDP dissociation inhibitor (RhoGDIalpha), which binds the ge

187 interaction augmented Rho guanine nucleotide dissociation inhibitor sequestration by ezrin and Rac1 a

188 into the cells was shown to bind to rab GDP dissociation inhibitor, suggesting that this pool of VP2

189 Thus, eRF1 acts as a GTP dissociation inhibitor (TDI) for eRF3, promoting efficie

190 f Ca2+/calmodulin and Rab guanine nucleotide dissociation inhibitor that are available for binding to

191 D4-GDI is a Rho GDP dissociation inhibitor that is widely expressed in hemat

192 Rho-GDIs are a family of Rho GDP-dissociation inhibitors that are critical in modulating

193 complex of Rab5 and GDI (guanine-nucleotide dissociation inhibitor), that was previously demonstrate

194 bind RhoA but coprecipitates RhoGDI (Rho GDP dissociation inhibitor), the primary RhoA repressor that

195 Fs), GTPase activating proteins, and guanine dissociation inhibitors to achieve the coordinated activ

196 Pases (by preincubation of vesicles with GDP dissociation inhibitor), together with cytosol immunodep

197 We then used immunodepleted cytosol and GDP dissociation inhibitor-treated vesicles to determine whe

198 extraction of rab4 (but not rab11) with GDP dissociation inhibitor was severely attenuated in NPF en

199 With the understanding of YM acting as a GDP-dissociation inhibitor, we propose that Ric-8A hinders Y

200 the cytosol bound to GDI (guanine nucleotide dissociation inhibitor), which binds to Rabs in their in

201 a), a Rho-family-specific guanine nucleotide dissociation inhibitor, which is involved in important c

202 n Rab5a and phosphorylated EEA-1 and Rab GDP dissociation inhibitor, with the latter causing Rab5a ac