ライフサイエンスコーパス: distal

1 The most distal 2 kb region in the majority of human subtelomeres

2 put within the dendritic branch (proximal vs distal), (2) the strength of the input pattern (subthres

3 dvanced recurrence, proximal recurrence, and distal adenoma recurrence with odds ratios of 4.32 (2.06

4 Regio- and stereoselective distal allylic/benzylic C-H functionalization of allyl a

5 em, which includes the trachea, airways, and distal alveoli, is a complex multi-cellular organ that i

6 also contribute to long-latency reflexes in distal and forearm muscles, alongside supraspinal region

7 Changes in distal and interstitial airspaces and the activation of

8 ucocorticoid treatment, interactions between distal and proximal GBSs and the TSS correlated with KLF

9 Furthermore, we show that mouse distal and proximal luminal cells are most similar to hu

10 Little is known about temporally distal and sex-specific effects, especially in cerebellu

11 tal stages by promoting cell division in the distal and ventral portion of the limb.

12 like NMDA spikes or trains of EPSPs from the distal apical dendrite to the soma in pyramidal neurons

13 f excitatory cells, preferentially targeting distal apical dendrites and apical dendritic tufts of py

14 nnels through dendodendritic inputs on their distal apical dendrites.

15 Distal appendages (DAs) of the mother centriole are esse

16 trosomal protein 83 (CEP83) eliminates these distal appendages and disrupts the anchorage of the cent

17 a genome-wide screen, we identify centriole distal appendages as critical for PIDDosome activation i

18 The mother centriole in RGPs develops distal appendages that anchor it to the apical membrane.

19 sence of an asparagine, imply the use of the distal arginine as a catalytic base.

20 Distal attachments can be used to restrict the mechanism

21 s opposed to stable microtubules) within the distal axon, illuminating a novel mechanism underlying s

22 iculum, integrins and Rab11 endosomes in the distal axon, whilst removing Protrudin's endoplasmic ret

23 a, and identified that Para is enriched at a distal axonal segment.

24 ileostomy types were end (20%), loop (10%), distal blowhole (59%), and proximal blowhole (11%).

25 e then anastomosed with the proximal and the distal bowel, respectively.

26 ") completely regenerate the digit tip after distal, but not proximal, amputation.

27 te that FFA4-L phosphorylation occurs on the distal C terminus and is directly responsible for recrui

28 entering the central channel of Rho from the distal C-terminal side of the ring.

29 is studies reveal that the engagement of the distal C-terminus of Galphai/o with the receptor differe

30 In parallel, distal CA3 of aged rats may create weaker attractor basi

31 in proximal CA3, but possibly hypoactive in distal CA3, compared with young (Y) rats.

32 radient in mean firing rate from proximal to distal CA3.

33 A distal candidate Runx1 enhancer exhibits high chromatin

34 and 9 (6%) with intrahepatic, perihilar, and distal CCA, respectively.

35 We identified distal cCREs with age-increased activity linked to SARS-

36 asts and a gradual decrease from proximal to distal cell columns as cytotrophoblasts differentiate in

37 trol of concrete, proximal actions and motor-distal, cerebellar sub-regions supporting abstract, futu

38 s and do not account for non-proximal to non-distal changes.

39 emonstrate that GLI1 and SMARCA2 co-occupy a distal chromatin peak and that SMARCA2 recruitment to th

40 ong terminal repeat (LTR) transposons in the distal chromatin that are younger than those affected by

41 ks key local enhancers, and instead contains distal chromosomal fragments harboring CRC-driven enhanc

42 Enhancers are distal cis-regulatory elements that activate the transcr

43 The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum

44 : 0.83, 0.96; P-trend < 0.001), particularly distal colon (HRQ5 vs. Q1: 0.84; 95% CI: 0.73, 0.96; P-t

45 e stimulation inhibited both contractions of distal colon and propulsive contractions represented by

46 ial diet scores were associated with risk of distal colon and rectal cancers, after adjusting for oth

47 xons arising from DRG were identified in the distal colon and their morphological features and CGRP i

48 This mechanism relies on a population of distal colon macrophages that are equipped with "balloon

49 s with Hirschsprung disease was used to show distal colon without enteric ganglia, as well as a trans

50 ons were removed, and colon contents (feces, distal colon, and tumor) were collected.

51 icrobiota, and a minor form derived from the distal colon, which adheres to the major form.

52 ertebral ganglion innervated the proximal or distal colon, with processes closely opposed to multiple

53 y differences between the ileum and proximal/distal colon.

54 ic stimulation was unique to the proximal or distal colon.

55 we demonstrate the concurrent development of distal colonic aganglionosis and intestinal ganglioneuro

56 lon organoids (colonoids) generated from the distal colons of mice.

57 Twenty-one days later, distal colons were removed, and colon contents (feces, d

58 us modulated DM-binding affinity, suggesting distal communication between peptide interactions with t

59 notype for cardiovascular disease, including distal conduction disease, AF, and atrioventricular pre-

60 he hip including sequences of the pelvis and distal condyles between May 2017 and June 2018.

61 otetramer in the basolateral membrane of the distal convoluted tubule (DCT) and plays an important ro

62 of distal tubule precursors into early stage distal convoluted tubules (DCTs) during nephrogenesis.

63 ly presented in podocytes, proximal tubules, distal convoluted tubules, and the apical membrane of co

64 ated in proximal and middle as compared with distal coronary segments (DeltaFFR(eng)-FFR(dis), proxim

65 th a larger proportion of stele, and smaller distal cortical cells).

66 ool was associated with an increased risk of distal CRC.

67 Elimination of distal CS to LA connections reduced atrial arrhythmia re

68 embrane proximal (D1) domain and an inactive distal (D2) pseudophosphatase domain.

69 Control mice exhibited a large proximal-to-distal decrease and a moderate mesentery-to-antimesenter

70 pt innervation exhibited a muted proximal-to-distal decrease in control mice and a smaller loss after

71 degeneration (WD) is a process of autonomous distal degeneration of axons upon injury.

72 ctions: (1) dendrodendritic synapses onto GC distal dendrites via their lateral dendrites in the supe

73 input through specialized synapses on their distal dendrites.

74 trotonic dendritic structure causing a leaky distal dendritic compartment with correspondingly low in

75 A3 region, neurons with higher proportion of distal dendritic length display a higher tendency to fir

76 zation of GluN2B-NMDARs between proximal and distal dendritic segments, whereas the topography of Glu

77 n variability was lowest at the level of the distal descending aorta (DDA) with median COVs of 1.6% f

78 s shows heightened inflammatory signaling in distal differentiated (ALDH-) TE.

79 ion and can accelerate the identification of distal disease-associated risk variants.

80 Distal diuretics are considered less effective than loop

81 To investigate whether distal diuretics are noninferior to dietary sodium restr

82 s show that such C-walks are consistent with distal domains being topologically insulated, that is, n

83 and kctd15b function in concert to restrict distal early (DE)/thick ascending limb (TAL) segment lin

84 demonstrate by targeted deletions that these distal elements are required for appropriate gene induct

85 y reducing H3K27ac on promoter-proximal and -distal elements of negative regulators of neurogenesis.

86 in should, when rotated, impair search for a distal ellipse.

87 ry intervention to decrease the incidence of distal embolization, periprocedural myocardial infarctio

88 "photonic lantern" transition formed at the distal end by tapering.

89 While the distal end of the centriole templates the cilia, the pro

90 tor proteins becomes highly polarized to the distal end of the cilia during cytoplasmic ciliogenesis

91 we measure with a Hall sensor mounted to the distal end of the solenoid core.

92 ne end of the barrel can be evaluated at the distal end.

93 e results through functional dissection of a distal enhancer cluster using CRISPR-Cas9 deletions.

94 suggest the existence of a stimulus-specific distal enhancer modulating BDNF gene expression.

95 locus at chromosome 11q13.5(2-7) contains a distal enhancer that is functional in CD4(+) regulatory

96 specification with a pathological, looping, distal enhancer-based form of transcriptional regulation

97 Transcription activation by distal enhancers is essential for cell-fate specificatio

98 ntified TCF/LEF-binding sequences within two distal enhancers of the IrxB locus that promote beta-cat

99 Distal enhancers play pivotal roles in development and d

100 OCRs found primarily in loci consistent with distal enhancers.

101 on to establishing low methylation levels at distal enhancers.

102 es beyond the retinal image; we perceive the distal environment itself, not the proximal stimulation

103 igh risk T2-4a, pathologically node-negative distal esophageal adenocarcinoma.

104 ents with esophageal cancer localized in the distal esophagus or gastroesophageal junction undergoing

105 ic levels of esophageal acid exposure in the distal esophagus with absence of reflux-symptom associat

106 t cancer cell lines and indirectly through a distal estrogen-responsive region in ERalpha-positive ce

107 rst-firing by setting the relative amount of distal excitatory inputs from the entorhinal cortex.SIGN

108 though previously postulated to bind to the 'distal' face, three statistically disordered double stra

109 connecting circuit-defined subtypes to more distal features derived from digital phenotyping and wea

110 perfusion imaging of knee bone marrow in the distal femoral condyle at a 3 T MRI scanner, a study was

111 Conclusion A distal femoral cortical irregularity at the attachment s

112 ike cortical irregularities at the posterior distal femur are common incidental findings in adolescen

113 ssed in the atypical epithelial cells of the distal fibrotic regions.

114 ignins varied only by root orders, where the distal (first and second) root orders had lower lignin c

115 The distal fragment was utilized to place a guide wire, and

116 Reported herein is the distal gamma-C(sp(3) )-H olefination of ketone derivativ

117 The primary outcome was a diagnosis of distal gastric adenocarcinoma 30 days or more after dete

118 n with H. pylori is the main risk factor for distal gastric cancer.

119 -induced expression of AHR in neurons of the distal gastrointestinal tract enables these neurons to r

120 corticoid response element (GRE) within each distal GBS.

121 the correlation between chromatin states of distal genomic elements.

122 strain-level metagenome-assembled genomes of distal gut bacteria from two participants, including 12,

123 e different neural crest cell populations in distal gut innervation, and consequently to improve the

124 the identified genes were detectable in the distal gut microbiomes of most individuals living in nor

125 Distal H-bonding substitutions of the N(6)-(2-phenylethy

126 nternalization, K552T and R553L mutations at distal helix B decrease calmodulin-binding and axonal en

127 ch thus provides unique insight into how the distal heme site of DyPs can be tuned to select aspartat

128 These structures reveal a water-free distal heme site that, together with the presence of an

129 Distal hereditary motor neuropathies (HMNs) and axonal C

130 y mimicking amyotrophic lateral sclerosis or distal hereditary motor neuropathy (56%), multinevritis

131 High-output pacing at the distal His location delivered PHCs.

132 e with the C1 carboxylate group trans to the distal histidine (His211); (2) The decay rate constant o

133 Strikingly, in the absence of the distal homologous chromosome arm dnTA is further increas

134 ernal carotid artery (cICA) can be caused by distal ICA occlusion.

135 ociated with the Ries impact, is overlain by distal impact ejecta in situ, forming a unique continent

136 istribution of Evans Blue Dye using a double distal injection (DDI) approach compared with a single p

137 to granule cells that are more powerful than distal inputs and fail to depress with repeated stimulat

138 and disease-associated variants enriched at distal interacting regions in a cell-type-specific manne

139 nal Mn efflux and indicate the importance of distal intestinal segments to vitamin D action.

140 5 expression increasing predominantly in the distal intestine and the kidney.

141 been suggested that calcium transport in the distal intestine involves a paracellular process, we fou

142 ) are also induced by 1,25(OH)(2)D(3) in the distal intestine of KO/TG mice.

143 of the vitamin D receptor (VDR) only in the distal intestine of VDR null mice (KO/TG mice) results i

144 and anterograde tracing identify a subset of distal intestine-projecting vagal neurons that are posit

145 uced by 1,25(OH)(2)D(3) in both proximal and distal intestine.

146 s two adjoining capsid subunits and promotes distal intra- and inter-hexamer interactions that stabil

147 Four pairs of distal, intramonomeric disulfide bonds are found to be c

148 minimal for motoneurons innervating the most distal intrinsic hand muscles.

149 sensitivity of AR-positive cells is due to a distal K79 methylation-marked enhancer in the MYC gene b

150 s downstream to increase sodium transport in distal kidney nephron epithelial cells.

151 significantly improved peptide function and distal killing, it also reduced surfactant spreading.

152 exposure, followed by membrane curvature and distal leaflet engagement.

153 stalk formation and then acts to engage the distal leaflets of each membrane and promote stalk widen

154 rminal domain with (TDD) or without (TD) the distal leg inhibits CME and CCP dynamics by perturbing c

155 ea fowl (Numida meleagris) revealed that the distal leg muscles rapidly modulate force and work outpu

156 on, but its ferric form does not release the distal ligand, while the return to the ground state has

157 We find that upon ectopic expression in distal limb buds, HOXA11 binds sites normally HOX13-spec

158 luster was co-opted to be transcribed in the distal limb ectoderm, where it is activated following th

159 do not contribute to the regeneration of the distal luminal compartments.

160 The distal lung contains terminal bronchioles and alveoli th

161 re performed with unlabeled BMP on the human distal lung epithelial cell line NCI-H441.

162 alveolar type II (AT2) cells, progenitors of distal lung epithelium, and in IPF lung slice cultures.M

163 es a facile in vitro organoid model of human distal lung infections, including COVID-19-associated pn

164 We created distal lung organoids with apical-out polarity to presen

165 This long-term, feeder-free culture of human distal lung organoids, coupled with single-cell analysis

166 -free, chemically defined culture system for distal lung progenitors as organoids derived from single

167 signature with basal cells obtained from the distal lung tissue of IPF lungs.

168 ease characterized by patchy scarring of the distal lung with limited therapeutic options and poor pr

169 e epithelial-mesenchymal-myeloid unit of the distal lung, thereby opening numerous new avenues to stu

170 ich if inhaled, reach the central airway and distal lung.

171 .001) between the most proximal to the most distal measurement methods.

172 f FLAIR-HAs defined by location (at proximal/distal middle cerebral artery (MCA), within/beyond diffu

173 r microstructure to measures of proximal and distal motor function in patients after hemispherotomy.

174 y motor areas to not only proximal, but also distal muscles of the arm.

175 exes and lack information about the receptor distal N-termini, despite the importance of the latter i

176 (-3 subsite) and Trp(234) (-5 subsite) from distal negative subsites have a key role in galactomanna

177 zing the transcriptional distinction between distal nephron and ureteric epithelium in human fetal ki

178 nephron-containing kidney organoids contain distal nephron epithelium and no ureteric epithelium, th

179 epithelium and no ureteric epithelium, this distal nephron segment alone displays significant in vit

180 th aged controls, whereas TMPRSS2 (primarily distal nephron) was highest in telmisartan-treated anima

181 ury triggers sterile inflammation within the distal nerve and axotomized dorsal root ganglia (DRGs).

182 ning (NHEJ), as well as between proximal and distal NHEJ repair.

183 ighly conserved NFAT binding site within the distal noncoding element hHS-8 coordinately controls TNF

184 ion or glutamate-to-alanine substitutions at distal NT causes constitutive cell death.

185 irect evidence that PRC2 can bridge pairs of distal nucleosomes.

186 surface ((I)O and (III)O) and one that is a distal O extending toward solution.

187 find that intergenic SNPs tend to locate in distal OCRs, and our chromatin interaction maps provide

188 not only proximal cooperative goals but also distal ones via the construction of shared understanding

189 ies, 113 partial pancreatoduodenectomies, 79 distal pancreatectomies, and 10 resections for tumor rec

190 Findings differed between fistulas after distal pancreatectomy and pancreatoduodenectomy.

191 idely implemented, early drain removal after distal pancreatectomy is associated with better outcomes

192 with impaired ROMK apical expression in the distal part of the renal tubule.

193 sition of pulmonary emboli mirrored the most distal part of venous thrombi from which they originated

194 e layer of the PKJ and the adventitia of the distal pelvis.

195 complications, patient outcomes, and use of distal perfusion cannula, were extracted from selected a

196 before (baseline) and directly after (0-5 h) distal, permanent MCA occlusion (pMCAo) in a rat model.

197 ically proposed class of mechanisms, termed "distal pinning," achieves robustness by combining local

198 as a pheromone-promoted polarity cue in the distal pole of the cells.

199 of RAD21 cohesin complex protein can recover distal polyadenylation site usage.

200 in a molecule are possibly transmitted to a distal position through interposed conjugated multiple b

201 ence supporting participation from remote or distal positions is critically examined, and alternative

202 pression leads to increased density and more distal positions of branches.

203 sed spinule number, length, and contact with distal presynaptic elements.

204 mental to ensuring delivery of Task3 mRNA to distal primary cortical neurites.

205 Luminal-C cells located at the distal prostate invagination tips (termed Dist-Luminal-C

206 LV(EV), distal pulmonary venous blood volume for vessels smaller

207 At the distal PV sites, only IRF ablations were grossly identif

208 We also identified two distal quinone-binding sites with bound quinones.

209 which is inserted into the skin, and a more distal rachis.

210 in biparental populations to delimit B1 to a distal region of 5AL colocalized with QTL for number of

211 s carcinomas (HGSCs) likely originate in the distal region of the Fallopian tube's epithelium (TE) be

212 Pontin-FOXO3a signaling axis can work in the distal regions and activate autophagy genes through enha

213 etrograde tracers injected into proximal and distal regions of colon or bladder, followed by single-c

214 We found that distal regions of each leg bind N-terminal Habc domains

215 ction network that links effector binding to distal regions of the fold that support the gene-off RNA

216 in neoGATA3-expressing cells, especially at distal regions, suggesting that neoGATA3 interferes with

217 ic changes, we observed that the majority of distal regulatory elements are constitutively unmethylat

218 During gene induction, these distal regulatory elements behave in an atypical manner,

219 Distal regulatory elements control gene expression durin

220 Physical interactions between distal regulatory elements have a key role in regulating

221 y of gene promoters to integrate inputs from distal regulatory elements, yet how this is achieved rem

222 ability to accurately link genes with their distal regulatory elements.

223 expression regulation involves thousands of distal regulatory elements.

224 Long-range interaction of promoters with distal regulatory loci, monitored by promoter capture Hi

225 hat GLI1 controls chromatin accessibility at distal regulatory regions by modulating the recruitment

226 sease-associated variants are often found in distal regulatory regions with cell-type specific behavi

227 astic changes in the threshold current and a distal relocation of FGF14, a protein physically bridgin

228 ex while not affecting overall affinity, and distal residues within the activator-not often considere

229 Q. alba, the ellagitannins decreased in the distal root orders exposed to drought, while the fiber-b

230 Despite a lower lignin content, the distal root orders had higher content of guaiacyl lignin

231 he restriction of formative divisions to the distal root region.

232 s including fungi, which are enriched in its distal segment.

233 dis), proximal and middle 0.04+/-0.03 versus distal segments 0.03+/-0.03; P=0.042).

234 A distal-selective alkenyl C-H arylation method is reporte

235 Three individuals had additional distal sensory loss.

236 ng abnormalities; peripheral neuropathy with distal sensory symptoms, such as numbness, paresthesia,

237 t to a proximal regulatory signal, then to a distal signal that organizes digits.

238 rine CD8(+) T cells, we found a programme of distal signalling events that is shared, regardless of t

239 se trains) at each PV in a proximal and in a distal site.

240 g with additional recombination occurring at distal sites harboring virulence-associated genes.

241 tions in the translocation of endometrium to distal sites, with loss of cell integrity being a common

242 ription start site (TSS) and two occurred at distal sites.

243 methods to capture epistasis particularly at distal sites.

244 of Ag-specific CD8 T cells at both local and distal sites.

245 sis sensor" for detection of tumor burden at distal sites.

246 erhyperpolarization and coincident decreased distal spine density in striatal direct pathway striatal

247 proximal small SPs, proximal large SPs, and distal SPs were 4.7 (95% CI, 4.0-5.6), 14.8 (95% CI, 9.0

248 ng mechanism for KRAS, in which the membrane-distal state of the G-domain can effectively recruit RAF

249 Here, we show that IAA33 maintains root distal stem cell identity and negatively regulates auxin

250 ymers enable stable, long-lived operation as distal stimulators in a rat model of peripheral nerve in

251 d be aware of the thinnest dimensions in the distal surface of the MB roots of the maxillary first mo

252 chromosomal translocations, extensive use of distal switch regions (consistent with end resection), a

253 chieve efficient integration of subthreshold distal synaptic inputs compared with the same cell type

254 Comparative evaluation of proximal and distal TE cell population's shows heightened inflammator

255 hese samples were prepared from proximal and distal TE regions of 12 normal Fallopian tubes.

256 the basis for further mechanistic studies of distal TE susceptibility to the malignant transformation

257 e, placement of the catheter tip into the OA distal third versus medial and proximal thirds (P = 0.04

258 tor, specifically, through one enhancer, sna.distal This study demonstrates that continuous input is

259 ffects, fails to reverse elevated arousal to distal threat contrary to the beneficial effects we have

260 Conversely, distal threats allow increased information processing su

261 cell niche exit in the canonical C. elegans distal tip cell (DTC) germ stem cell niche mediated by p

262 imera was able to deliver CDHR2 and CDHR5 to distal tips in the absence of USH1C or ANKS4B.

263 a anatomically specialized "hotspots" at the distal tips of ChP villi.

264 ynamic length-matching activity that aligned distal tips over time.

265 d mortality, mechanisms governing seeding in distal tissues are poorly understood.

266 tiate localized infection and disseminate to distal tissues but was cleared from all sites by 14 days

267 Monitoring metastatic events in distal tissues is challenged by their sporadic occurrenc

268 munoglobulin domains preferentially from the distal titin spring region become oxidized in vivo throu

269 ts in vivo were present in a cortical region distal to (>0.7 mm) freeze-lesion-induced microgyrus, in

270 tronic differences between C-H bonds located distal to functional groups has prevented the developmen

271 ic pocket within the GSDMD C-terminal domain distal to its N-terminal domain.

272 iated mutations in IL-11Ralpha are generally distal to putative ligand-binding sites.

273 teins for analyzing diseased tissues near or distal to salivary glands using transcriptome or proteom

274 in accommodating the RNA-DNA hybrid product distal to the active site.

275 s to drive rapid fibronectin fibrillogenesis distal to the adhesion.

276 n-induced conduction system deletion of Tjp1 distal to the AV node (Tjp1(fl/fl); Kcne1(CreERt2)) did

277 ncy of LPS in the model using two injections distal to the cervix.

278 at structurally mimic GCP2/GCP3 subcomplexes distal to the gamma-TuRC "seam." We also identify an una

279 o the squamocolumnar junction and 3) 5-10 mm distal to the gastroesophageal junction, as demarcated b

280 lates antitumor immune response following RT distal to the gut.

281 itary cancer syndromes) and 66% were located distal to the hepatic flexure.

282 nd was more prominent in the cortical region distal to the microgyrus.

283 to rapid, programmed disintegration of axons distal to the site of lesion.

284 Altered haemodynamics distal to the web cause flow stagnation and remote embol

285 ing cysteines within the DNA-binding domain, distal to the zinc-binding site.

286 hanges at proximal sciatic nerve branches or distal toe nerve fascicles at the vincristine dose used

287 wn to be required for the differentiation of distal tubule precursors into early stage distal convolu

288 of these factors colocalized with tfap2a in distal tubule precursors.

289 In the kidney, proximal and distal tubules had markedly higher mtDNA levels compared

290 cells differentiate into mature proximal and distal tubules, whereas expression of the related Pax8 p

291 somatic region, resulting in a decoupling of distal tuft branches from each other while at the same t

292 ween the classic I44 hydrophobic face of the distal Ub and the conserved MGF hydrophobic patch of the

293 ing, movement, and subsequent unloading into distal uninfected tissues.

294 mor is a fine rhythmic oscillation involving distal upper limbs, linked to increased sensorimotor cor

295 Upon deflection of distal upstream DNA over the RNA polymerase zinc-binding

296 potential of linear RAG scanning to mediate distal V(H) usage in G1-arrested v-Abl pro-B cell lines(

297 while triggering rapid stepwise movements of distal vesicles along the ribbon and toward the plasma m

298 Dilated distal vessels extending to the pleura and fissures were

299 ADM-adjacent untreated sites (on mesial and distal) via mixed-modeling regression analyses.

300 d primarily by motor neuron degeneration and distal weakness.