ライフサイエンスコーパス: distant

1 uation that was temporally/spatially near or distant.

2 other methods when the genomes are large and distant.

3 s applicability in small scale industries is distant.

4 We also discover a distant (25 angstrom) ligand-binding site unique to SARS

5 t did not: locoregional (0 vs 3, P = 0.061), distant (9 vs 3, P = 0.135) and any recurrence (11 vs 7,

6 is through its varied secretome that targets distant adipose depots, skeletal muscle, and the nervous

7 sed infiltration of PD-L1(+) TAMs as well as distant alterations in the bone marrow (BM).

8 ng the c.191A > G variant, consistent with a distant ancestor common to both families.

9 The shared, but temporally distant, ancestry of the banded mongoose and domestic fe

10 Dominant males are spatially distant and have lower signal-to-noise ratios of informa

11 l for more time also viewed them as socially distant and less human, described immigration in imperso

12 ces is decisive in the context of generating distant and long-lived C(60)(*-)-ZnP-Fc(*+) charge-separ

13 The binding specificity of P47Rec from distant anophelines (Anopheles gambiae, Anopheles dirus,

14 mic lineages) had their closest relatives in distant areas, instead of the neighbouring Italian Penin

15 ibility to a restriction enzyme, at sites as distant as 40 nm, due to an increase in global fluctuati

16 ss-protection potential between evolutionary distant ASFV strains and strongly suggest that C-type le

17 = 18) of the total cohort (n = 15 LR, n = 3 distant), at median follow-up of 36.7 months.

18 re, causing cancer cell hypoxia and death in distant avascular regions.

19 echanism of formation of large loops between distant basepairs.

20 lectivity over other BRD family proteins and distant BD-containing proteins.

21 morigenesis in the oral cavity as well as in distant body sites.

22 widely thought that cortical projections to distant brain areas derive by and large from glutamaterg

23 ct to, cortical areas are thought to entrain distant brain areas for efficient information transfer a

24 ally coordinated neuronal ensembles-coupling distant brain regions, gating processing windows, and pr

25 p to almost 10,000 km) migration to and from distant breeding sites as well as across many decades.

26 ed in the inverted region, while that of the distant C(60)(*-)-ZnP-Fc(*+) charge-separated state lies

27 metabolism in which redox transformations in distant cells are coupled via long-distance electron tra

28 function as external signaling molecules to distant cells.

29 ed a closer center and sought care at a more distant center.

30 used on small children, and cooperating with distant centers throughout the country.

31 ons, and long-ranged dielectric screening of distant charges, competing effects that are difficult to

32 However, when the genomes are large and distant, classical median solvers have failed to adequat

33 gy of the delaminated nanosheets, with quite distant cobalt centers, precludes the direct coupling be

34 d that, under a sufficiently severe and time-distant collapse, how much the actors care for the futur

35 round optix and WntA in H. melpomene and its distant comimic Heliconius erato Ultimately, we show tha

36 However, proximal (a few meters distant) communities with gene-inferred aerobic, microae

37 ic simultaneously impacting populations from distant continental habitats.

38 may be modulated by top-down influences from distant cortical areas, particularly in the frontal and

39 nogen is enriched in the SVZ niche following distant cortical brain injury in mice.

40 Uruguay, and are present in minor numbers in distant countries.

41 and exploit, both prediction and its rather distant cousin, predictive coding.

42 This facilitates the contacts of AEs with distant CTCF sites near promoter of other cell-cycle gen

43 r the life-cycle indicating high fraction of distant diffusion in early stages but the dominance of l

44 t phages with near-identical core genomes in distant, discrete aquatic ecosystems maintain diversity

45 = 0.672) and 14% with synchronous local and distant disease (10% of pN0 and 15% of pN1, P = 0.292).

46 ikely to present with local than regional or distant disease at diagnosis (80/82; 97.6% exposed vs. 1

47 e pelvic nodes in 26.2% (68/260), and showed distant disease in 17.7% (46/260).

48 nt and to examine its effects on short-term, distant disease-free survival (DDFS).

49 inhibition by Rictor/mTORC2 deletion blocks distant dispersal, restricting glioma growth in the SVZ.

50 e patients, suggesting greater potential for distant dissemination.

51 In summary, by ascertaining height loci in a distant East Asian population, we further supported the

52 Comparison to a distant eastern Indian Ocean site (Western Australia, n

53 tromal remodeling but also the generation of distant ECM-enriched stromal niches in vivo.

54 However, coupling between distant electron spins, which is required for quantum er

55 ty of imaging in the assessment of local and distant endocarditis complications such as pericardial s

56 unctionally characterized MM-specific active distant enhancers controlling the expression of thioredo

57 mains (TADs) that link promotor regions with distant enhancers.

58 bly clustered within cells at random points, distant enough to be resolved by a microscope but close

59 e evolution condition can matter strongly in distant environments.

60 tion of 6706 and 4628 significant local- and distant-eQTL associations, respectively.

61 The cumulative incidence of distant failures did not differ between the treatment gr

62 omote in situ bone regeneration at locations distant from existing host bone, whereas bone regenerati

63 kingdom of oomycetes and is phylogenetically distant from fungi, employ the host plant's Argonaute (A

64 ntibacterial compounds that are structurally distant from known antibiotics.

65 from other volcanoes richer in acids or more distant from propagule sources could show a different pa

66 ws" are longest in cortical regions that are distant from sensory input.

67 ations at sites spread across the genome and distant from telomeres.

68 f Sws2 cone photopigments, evolutionary-more distant from template bovine RH1, and provided mechanist

69 t into how specific amino acid substitutions distant from the active site in a Klentaq DNA polymerase

70 ctor X and intrinsic Xase occurs at exosites distant from the active site, followed by active-site do

71 xes, and screened small molecules, that bind distant from the active site, for their ability to modul

72 ide-binding site at the surface of domain A, distant from the catalytic site and not previously ident

73 compelling evidence that a domain spatially distant from the gB fusion loops is critical for herpesv

74 Macrophage recruitment occurred at the NMJ, distant from the nerve injury site, to support functiona

75 l epitope in the arm region of the prodomain distant from the proteolytic cleavage sites.

76 e, we tested the effect of R805W, a mutation distant from the putative client-binding region, which i

77 ells can be isolated and compared with cells distant from the tumor bulk, using a variety of ex vivo

78 sites of ChH1A and ChH1B strains were 10-60% distant from those of commercial vaccine strains at the

79 assembly, maturation and quality control of distant functional centers during ribosome formation.

80 Overall, the study presents a way to get distant functional groups to communicate with each other

81 a molecular mechanism that may shuffle more distant genes into the cluster, so enabling cluster comp

82 ostic value of a new clinical-genomic model, Distant Genetic Model-Clinical Variable Model 6 (DGM-CM6

83 Haplotype reconstruction of distant genetic variants remains an unsolved problem due

84 racetylation results in interactions between distant genomic loci separated by tens to hundreds of me

85 nsights into how urea-based compounds engage distant GIRK1 residues required for channel activation.

86 lignment of those same sequences to the more-distant GRCh38 genome, illustrating one of the benefits

87 nitiator aminoacyl-tRNA at the P site to the distant GTPase center through interdomain communications

88 re not restored until after reinnervation by distant gustatory ganglion neurons.

89 for local food webs, as a trophic subsidy to distant habitats and for inshore carbon cycling and (pot

90 uence alignment and homology modeling showed distant homology between GP38 and the ectodomain of Gn (

91 re of GP38, which revealed a novel fold with distant homology to another CCHFV glycoprotein that is s

92 ther methods, when the genomes are large and distant, IDQPSO-Median has the lowest median score, the

93 cell surface O-linked glycans for local and distant immune modulation.

94 , we show how many details of this extremely distant interaction are explained by water waves quantif

95 ifferent breast cancer subtypes and sites of distant involvement.

96 he appearance of 2 or more new PSMA-positive distant lesions.

97 rve the fish navigation in the presence of a distant light source.

98 astern Mediterranean had access to food from distant locations, including South Asia, and such goods

99 large-scale whole-body movements directed at distant locations.

100 lasses that contained samples collected from distant locations.

101 he transport of nutrients and energy between distant locations.

102 rganizes the genome by topologically linking distant loci, and is highly enriched in specialized chro

103 loci, lack of linkage disequilibrium between distant loci, incongruent haplotype phylogenies across t

104 lesions within the prostate fossa, local and distant lymph nodes, bones, or visceral organs was recor

105 r their nucleotide-binding sites, but not at distant lysine residues.

106 ocial processing across two phylogenetically distant mammal species.

107 scriptome sequencing of normal, primary, and distant mCRC tissues we find 148 differentially expresse

108 Csx3 is a distant member of the CARF domain superfamily previously

109 isms are more closely related to nearby than distant members of their species, creating spatial autoc

110 he patients who recurred, 62% presented with distant metastases (63% of pN0 and 62% of pN1, P = 0.553

111 eoadjuvant group, in which 68% recurred with distant metastases (76% of pN0 and 64% of pN1, P = 0.326

112 hazard ratio, 18.7; P < .0001), formation of distant metastases (hazard ratio, 32.1; P < .0001), and

113 alized on PET/CT, localized disease, and any distant metastases (M1) were 20%, 43%, and 37%, respecti

114 node metastases (n = 17 out of 29, 59%) and distant metastases (n = 20 out of 70, 29%), but less fre

115 ut of 70, 29%), but less frequent in treated distant metastases (n = 9 out of 94, 10%).

116 had fewer positive lymph nodes (P = .04) and distant metastases (P = .01), and had lower odds of an F

117 are shared between primary tumors and paired distant metastases although mutational signatures sugges

118 arcinoma (HNSCC), cell migration facilitates distant metastases and is correlated with poor prognosis

119 ng and the presence of lymph node as well as distant metastases and is specifically up-regulated in C

120 achieved in primary tumors, lymph nodes, and distant metastases at 1 h after injection, with an SUV(m

121 ial to almost perfect except for judgment of distant metastases based on the PSMA Reporting and Data

122 Thus, lymph node and distant metastases develop through fundamentally differe

123 nsformed sympathetic neuroblasts, and drives distant metastases in vivo.

124 for salvage) occurs in 25% of patients, and distant metastases occur in 10% of patients.

125 ) six of seven cases with recurrence and all distant metastases were of MSFs, (iii) recurrence-free s

126 There were no patients with (18)F-FDG-avid distant metastases without (18)F-FES-avid distant metast

127 22 local recurrences, 63 lymph nodes, and 31 distant metastases).

128 id distant metastases without (18)F-FES-avid distant metastases, although in one patient liver metast

129 e represents one of the most common sites of distant metastases, and spinal bone metastasis is the mo

130 the pelvic lymph nodes or showed evidence of distant metastases, as indicated by PSMA PET/CT.

131 Up to 50% of patients develop distant metastases, but current systemic therapies have

132 The primary outcome measure was freedom from distant metastases, designed with 80% power to detect an

133 ncreases both primary tumor growth rates and distant metastases.

134 ng cancer (NSCLC) primary tumors and matched distant metastases.

135 cells becoming the predominant population in distant metastases.

136 a-lesion heterogeneity in lymph node than in distant metastases.

137 mortality rates exceed 70% in patients with distant metastases.

138 eoadjuvant treatment as locoregional (LR) or distant metastasis (DM).

139 HR], 1.37 [95% CI, 1.12 to 1.68], P = .002), distant metastasis (sHR, 1.40 [95% CI, 1.00 to 1.95], P

140 We examined 281 lung cancer patients with distant metastasis and found that smokers exhibited a si

141 st tumours are significantly associated with distant metastasis and poor outcome in breast cancer pat

142 reduced risk of metastasis is mainly due to distant metastasis but not regional lymphatic metastasis

143 who had a clinical complete response without distant metastasis for 1 year was 93.8% (92.3-95.9), for

144 The probably of remaining free from distant metastasis for a further 2 years in patients who

145 our-initiating potential, local invasion and distant metastasis formation.

146 ression correlates with overall survival and distant metastasis free survival.

147 n in vivo blocked primary tumor invasion and distant metastasis in a mouse model of basal breast canc

148 icantly preventing both local recurrence and distant metastasis in malignant melanoma models.

149 ncer patients to identify genes that promote distant metastasis in mice.

150 ch adenocarcinomas and increased relapse and distant metastasis in triple-negative breast cancer.

151 estrogen-regulated gene expression, EMT, and distant metastasis in vivo, suggesting that AR may play

152 CI, 49 to 60) with placebo (hazard ratio for distant metastasis or death, 0.55; 95% CI, 0.44 to 0.70)

153 nger duration of survival without relapse or distant metastasis than placebo with no apparent long-te

154 ercentage of patients who were alive without distant metastasis was 65% (95% CI, 61 to 71) with dabra

155 romoted tumor angiogenesis and breast cancer distant metastasis without affecting primary tumor growt

156 65.2% had 1 site of distant metastasis, and 42.9% had bone-only metastases.

157 egions where BC cells first establish before distant metastasis, and the presence of tumor cells in t

158 This is mostly due to early local and distant metastasis, even after surgical resection.

159 mical failure, local or regional recurrence, distant metastasis, or death from any cause, or was cens

160 can become aggressive tumors associated with distant metastasis, shortening survival.

161 atment samples on breast cancer-specific and distant metastasis-free survival (BCSS and DMFS, respect

162 a combined prognostic score associated with distant metastasis-free survival (the time between rando

163 HER2DX was significantly associated with distant metastasis-free survival as a continuous variabl

164 The 5-year distant metastasis-free survival of the low-risk, medium

165 improvements in recurrence-free survival and distant metastasis-free survival with nivolumab versus i

166 ntiation signatures and predicts overall and distant metastasis-free survival.

167 vour the tumour microenvironment in terms of distant metastasis.

168 sive due to high incidence of recurrence and distant metastasis.

169 ssociated with tumor staging, lymph node and distant metastasis.

170 ors and associated with invasive disease and distant metastasis.

171 irculating PCa cells and subsequently reduce distant metastasis.

172 ntify a tight selective bottleneck preceding distant metastasis.

173 (CTC) disseminating is an important cause of distant metastasis.

174 d submental chains (Figs 1A and 1C), without distant metastatic disease.

175 vivo, suggesting that AR may play a role in distant metastatic progression of ESR1 mutant tumors.

176 tly different between primary tumors without distant metastatic recurrence (DMR) and metastases.

177 e activity from the local primary tumor to a distant metastatic site in vivo.

178 methyltransferase 3B (DNMT3B) is induced at distant metastatic sites and mediates epigenetic reprogr

179 Bone is the most common site of distant metastatic spread in prostate adenocarcinoma.

180 l kingdoms but also in more phylogenetically distant microorganisms such as green microalgae.

181 own how DAT is transported between spatially distant midbrain somatodendritic and striatal axonal com

182 show using a simple diagnostic that the more distant molecular torus is the dominant location for pow

183 simultaneous sensing of multiple, spatially distant mRNA regions and maturation marks.

184 e patients experienced relapse-local (n= 6), distant (n = 3), and combined (n = 3)-at a median of 9.8

185 well as anti-correlated connectivity between distant networks across domains.

186 c projections fine-tune activity in distinct distant networks and how their recruitment alters the be

187 the causal genes and mutations, including at distant noncoding sites.

188 ust immunity, leading to improved control of distant nonirradiated lesions via systemic type I IFN si

189 bone marrow and hematopoietic adaptation to distant noxia through transcriptional rewiring toward in

190 Significantly, eviction of the more distant nucleosomes is dependent upon the FACT histone c

191 hrough ISM compression, we find that certain distant nucleotide variants covary, including non-coding

192 the site of origin to a distinctly different distant organ in the face of immune and therapeutic atta

193 generating pro-metastatic environment at the distant organ sites, and by suppressing invasive propert

194 analysis of ferritins from two evolutionary-distant organisms has allowed us to propose a stepwise r

195 sues adjacent to melanoma lesions (skin) and distant organs (intestine) in tert mutants exhibited hig

196 as emerged as a promising tool in protecting distant organs against ischemia-induced damage.

197 tion of tumour cells, and remodel the ECM in distant organs to allow for metastatic progression.

198 ing of tumor cells from the primary tumor to distant organs, is responsible for the vast majority of

199 es from tumours leads to systemic changes in distant organs, where cancer cells metastasize and grow.

200 deficient in aging and mitigates fibrosis in distant organs.

201 cells in the bone marrow microenvironment or distant organs.

202 rticularly for the disseminated infection in distant organs.

203 cific molecular traits in order to spread to distant organs.

204 f their host and eventually disseminate into distant organs.

205 hen training and infection were initiated in distant organs.

206 ng of the correlations that can be shared by distant parties.

207 n the present may result from changes in the distant past, and highlights the need for integrating ev

208 economic development have their roots in the distant past.

209 are virus-specific and were acquired in the distant past.

210 of homozygosity (ROH)/heterozygosity ratio, distant pedigree computation, and mitochondrial DNA (mtD

211 ons generates significant contributions from distant periodic images of the simulation cell, usually

212 action for emigration into diverse organs in distant phyla.

213 ojections also exhibits a cross-talk between distant planes due to the discrete angular sampling and

214 ts will be engulfed by the star(2), but more distant planets can survive this phase and remain in orb

215 ing a common origin for these geographically distant populations.

216 lection of Diptera responds to the cues of a distant predator, the carnivorous elephant mosquito larv

217 e had the ability to initiate hunts based on distant prey odors.

218 Further imaging failed to identify a distant primary malignancy or metastatic disease.

219 synthesis, the empirical frequency of these distant propagating ecosystem imbalances appears to be g

220 s to determine their dementia risk remains a distant prospect.

221 ht on the reaction mechanism and the role of distant protecting groups in glycal reactivity.

222 ing local similarities in binding sites from distant proteins is a major hurdle to rational drug desi

223 , mrTDs/mrEMVI were strongly associated with distant recurrence (HR 6.53 (2.52-16.91) p = < 0.001) wh

224 lication and mortality rates (iii) local and distant recurrence (LR), (iv) disease free survival (DFS

225 survival (the time between randomisation and distant recurrence or death before recurrence), an explo

226 The overall rate of 8-year freedom from distant recurrence was 91.1% and ranged from approximate

227 95% CI, 0.39 to 0.64; P < .001), and risk of distant recurrence was lower in patients who received T-

228 aplan-Meier estimates of 8-year freedom from distant recurrence were analyzed using subpopulation tre

229 absolute improvement in 8-year freedom from distant recurrence with exemestane plus OFS versus tamox

230 a more than 97% rate of 8-year freedom from distant recurrence, and improvements with exemestane plu

231 I-DR) had significant differences in 10-year distant recurrence-free interval (DRFI) (94.1% vs. 85.0%

232 Distant recurrence-free survival (DRFS) was assessed by

233 With longer follow-up, we now focus on distant recurrence.

234 >= 11 experienced substantial risk of early distant recurrence.

235 biology to simulate patterns of local versus distant recurrences in a non-small cell lung cancer (NSC

236 l survival, disease-free survival, local and distant recurrences, adjusted for possible confounders.

237 hared genetic diversity among geographically distant regions and sites that resulted in substantially

238 ation and mapping of brain activities across distant regions in the deep brain with minimal tissue da

239 l expansion of the adaptive immune system in distant regions of the same tumor.

240 nabling functional connectivity (FC) between distant regions through coupling of their oscillations.

241 tion, mainly in the ipsilateral striatum and distant regions with synaptic links to the striatal lesi

242 flexible and may involve interactions among distant regions.

243 ve and delaying the spread to geographically distant regions.

244 emical modulation of brain activities across distant regions.

245 pening, which limits the marketing period in distant regions.

246 and behaviors of people in other, sometimes distant, regions.

247 rmation of molecule aggregates that can join distant regulatory elements, such as gene promoters and

248 w the protection effect attenuates when more distant relatives, such as grandparents are included alo

249 claustrum in the turtle Trachemys scripta, a distant reptilian relative of lizards.

250 weakened host defenses appear to have been a distant secondary driver of these major disturbance even

251 he rATL may contribute to the recognition of distant semantic relations that support insight solution

252 d region could be replaced by evolutionarily distant sequences, suggesting plasticity in the binding

253 r tool, Distanced, calculates how different (distant) sequences would be without sequencing errors.

254 ormation of new tumors upon rechallenge at a distant site.

255 me before they progress locoregionally or at distant sites as overt tumors.

256 foci, 208 lesions in lymph nodes, and 42 in distant sites in bones or organs, Eleven patients had ne

257 he direct vicinity of the source cell and at distant sites in the body via biofluids, and elicit a va

258 lls have impaired metastatic colonization to distant sites including liver, lung, kidney, bone, and g

259 rom adhesion sites to push membranes towards distant sites of new adhesion.

260 Tumor cells can spread to distant sites through their ability to switch between me

261 ed for disseminating tumour cells to engraft distant sites(4-6).

262 ays via the inflammatory microenvironment at distant sites, cautioning the clinical approach basing c

263 To colonize distant sites, circulating tumor cells must destabilize

264 In addition, even when located at distant sites, neuronal cells can receive signals from a

265 atment significantly inhibited metastasis to distant sites.

266 nt with epigenetic alterations that occur at distant sites.

267 localization, migration and dissemination to distant sites.

268 that abstract paintings were assigned to the distant situation significantly more often than represen

269 it disseminates to various organs including distant skin sites, the heart, the joint and the nervous

270 Osteomyelitis and distant soft tissue infection may occur less frequently

271 rombectomy is offered by only a few, usually distant, specialised centres and not by the many other,

272 tend to be clade specific, phylogenetically distant species often deploy closely related toxin domai

273 with the genomes of 16 additional close and distant species we estimated that almond and peach (Prun

274 s of insulation of BEAF-32 in evolutionarily distant species, i.e. D. melanogaster and D. virilis.

275 shifts being less likely between genetically distant species.

276 While outer distant spiral rainbands produce single-peak meteotsunam

277 h-velocity droplets resulting in formites at distant surfaces.

278 to predict the lambdamax of phylogenetically distant Sws2 cone opsins.

279 to faithfully transfer action potentials to distant synaptic regions but also to maintain their timi

280 ognate targets accelerate the recruitment of distant T cells through long-range homotypic signalling,

281 F signalling pathway impacts lifespan across distant taxa, by controlling the activity of nodal trans

282 oth within the gastrointestinal tract and at distant tissue sites.

283 The bone marrow senses distant tissue transformation at premalignant/preinvasiv

284 turbation by migratory helminths and move to distant tissues to influence the local reparative respon

285 ltiple metastases, including lymph nodes and distant tissues-a mode of dissemination that we term 'cl

286 ent tumours, and disseminate to and colonize distant tissues.

287 populations were observed to be genetically distant to each other as well as to other populations fr

288 burden, existing TWAS methods do not assess distant trans-expression quantitative trait loci (eQTL)

289 l by controlling both local tumor growth and distant tumor metastasis.

290 to complete eradication of both primary and distant tumors on a bilateral colorectal tumor model.

291 cancers, resulting in an abscopal effect on distant tumors, and improving responsiveness to anti-CTL

292 sion not only of primary, but also untreated distant tumors, and renders tumors responsive to anti-PD

293 r progression (growth of local, regional, or distant tumors, detected by imaging or biopsy).

294 ontrol of both irradiated and non-irradiated distant tumors, including metastatic tumors, when adrene

295 the tumor growth of both primary tumors and distant tumors, prolonging the survival of tumor-bearing

296 fective rejection of both virus-injected and distant tumors.

297 temic immunity that suppressed the growth of distant tumours after rechallenge.

298 el1 at phosphorylating chromatin in trans-at distant undamaged sites that are brought into physical p

299 where photosystem II (PSII) is localized to distant unstacked regions of the thylakoids that harbor

300 ive monofunctionalization of substrates with distant, yet equally reactive functional groups is diffi