ライフサイエンスコーパス: distinct

1 A distinct 12-hour clock exists in addition to the 24-hour

2 der tighter selection and consequently their distinct 3' UTR isoforms are more likely to have functio

3 A distinct (40-50 year timescale) spectral peak that appea

4 These results demonstrate a distinct advantage of NESMD over MD for the treatment of

5 ng to odorant representations that were more distinct after repeated sampling.

6 nents of these pathways localize to, or form distinct aggregates in the vicinity of, germ granules.

7 d before the gene duplication that generated distinct alpha- and beta-subunits.

8 m of the drug induced more pronounced and/or distinct alterations in the structure of the DMPC bilaye

9 s identified nine terpenes that were clearly distinct among the cultivars and likely contribute to di

10 rewired among the three species, leading to distinct anatomical and morphological outcomes.

11 sults establish MET(N375S) as a biologically distinct and clinically actionable molecular subset of S

12 cally different binding affinities, and with distinct and mutually exclusive binding modes.

13 (EPAS1 encoding HIF-2alpha), inhibited both distinct and overlapping transcriptional programs.

14 human microbiota within each organ system is distinct, and their compositional variation and interact

15 monocytogenes, prophages encode two to three distinct anti-Cas9 proteins, with acrIIA1 always present

16 Here, we show distinct antibody responses in children and adults after

17 genetic background to largely abrogate this distinct APA signature.

18 We further discuss how distinct appetite and satiation systems for each factor

19 of hypoxemia and Crs was characterized as a distinct ARDS phenotype.Objectives: To determine whether

20 s extremely complex dynamic allostery: three distinct aromatic amino acids jointly communicate occupa

21 -omic profiling to identify individuals with distinct BA phenotypes or 'ageotypes'.

22 ed the pathways used by two phylogenetically distinct bacteria to degrade three different plasticizer

23 cal samples from nonresponders (P = .04) and distinct baseline composition (P = .04), but no specific

24 in conventional monocytes and pMos revealed distinct baseline signaling profiles and far greater het

25 While distinct BET inhibitors are being pursued as therapies i

26 meningeal fibroblasts are transcriptionally distinct between brain regions and identify a regionally

27 tes that this difference likely results from distinct biological and disease initiation and progressi

28 ent binding properties directly translate to distinct biological functions: free IgE initiated allerg

29 propose three main diagnostic pathways with distinct biomarker sequences, in which amyloid-PET and (

30 l and bacterial infections and a molecularly distinct Blimp1(lo)Id3(hi) tissue-resident memory popula

31 In the periphery, APOE2 drove distinct blood metabolome profile highlighted by the upr

32 dependent evolution and being implemented by distinct brain architectures.

33 This structure shows the distinct break in TM6.

34 embrane tube arises from the assembly of two distinct bundles of helical filaments that have the same

35 t al. show that while IL-17 and IL-9 induced distinct but complementary molecular pathways, both cyto

36 alpha2delta1 and alpha2delta3 subunits play distinct but complementary roles in driving formation of

37 ve control is enacted by the FPN and CON via distinct but complementary roles reflected in network dy

38 ieved through parallelization of molecularly distinct but functionally overlapping pathways.

39 eceding BM fibril deposition, indicating two distinct but interdependent functions.

40 s in WNT and SHH medulloblastoma are usually distinct, but DDX3X is often mutated in both subgroups.

41 ion reaction that is required to produce the distinct carbon scaffold of colchicine.

42 Distinct catalytic features of the Poaceae TPS-a subfami

43 d of two intermingling but transcriptionally distinct cell types with differing capacities for intera

44 representing more than 100 transcriptionally distinct cell types.

45 of centromeric chromatin and kinetochores at distinct cell-cycle stages, revealing extensive reorgani

46 found in various protein complexes to confer distinct cellular functions, but how the multi-subunit c

47 ivalent, synergistic H3-tail binding causing distinct cellular localization and enhanced H3K9me3-nucl

48 nonymous codon substitutions can affect many distinct cellular processes, which has complicated attem

49 This is the first study reporting the distinct cellular protein targets of mHAAs and mHAMs at

50 can concurrently mediate the degradation of distinct cellular substrates.

51 the potential to become drug candidates for distinct central nervous system pathologies and possessi

52 These distinct cerebellar-cerebral interactions respond differ

53 , we show that directional TMS can probe two distinct cerebellar-cerebral pathways that likely contri

54 fic monomer sequences exhibit unexpected and distinct charge transport pathways that enhance molecula

55 ts within phospholipid bilayers represents a distinct class of phase transformation that occurs in st

56 acellular milieu of the lung associates with distinct clinical phenotypes of COPD, including increase

57 P1P2 is unique in that it contains a pair of distinct ClpP1 and ClpP2 rings and also requires the pre

58 t-synaptic muscle fibers displayed increased distinct clusters of acetylcholine receptors and axon te

59 bodies (MB), we discovered transcriptionally-distinct clusters that exhibit neuroanatomical parcellat

60 rom infected individuals were grouped into 3 distinct clusters with 7 unclustered individuals.

61 The human nasal passages host a distinct community of microbes.

62 in clinic but rather to an intermingling of distinct community transmission networks.

63 ight into how different DNA sequences select distinct compositions and configurations of homeodomain

64 knowledge networks in which nodes represent distinct concepts and edges represent the similarity bet

65 risingly, RSV G complexed with 3G12 adopts a distinct conformation not observed in previously describ

66 Structural studies have revealed distinct conformations of S, but real-time information t

67 rs can be partitioned into four biologically distinct consensus molecular subtypes (CMS1-4) using gen

68 We highlight the distinct contributions of coagulopathy, thrombocytopathy

69 These results imply distinct contributions of FEF and caudate neurons to rew

70 in multiple areas of the visual cortex, with distinct contributions of higher areas to specific aspec

71 ties of unexpected germline recombination in distinct Cre driver lines designed for nervous system-sp

72 While each of these papers is a distinct creative effort of its authors, I would like to

73 P) score adapted to plasma biomarkers in two distinct databanks from studies that examined either adu

74 anism of engaging G-proteins that may have a distinct dependence on PIP(2) compared with class A GPCR

75 a few hundred meters apart had significantly distinct diets in childhood and adulthood.

76 Our results indicate there are distinct differences between the UBE2K-Ub and UBE2K-Ub(2

77 used rat models of HFpEF and HFrEF to reveal distinct differences in intracellular calcium regulation

78 he effectiveness of Ag-specific therapies to distinct disease endotypes.

79 influences contribute to pathogenesis during distinct disease states (ie, the ugly).

80 complex task because of the large number of distinct disorders, which requires involvement of patien

81 ise many architecturally mosaic genomes with distinct DNA sequences.

82 re represented by the presence or absence of distinct DNA strands, called molecular bits (molbits).

83 is substantial cotransport of proteins from distinct domains in the retrograde direction likely due

84 fested as a spontaneously broken symmetry in distinct domains of opposite polar orientation.

85 ug classes evaluated, the method detected 19 distinct drug exposures with statistically significant,

86 terns provide a dynamic migration assay with distinct dwell times and relative cell occupancy as read

87 Deep shotgun metagenomics unveiled distinct ecological niches of microbes and antibiotic re

88 dality microdroplets, we were able to obtain distinct edges of tumor and blood flow mapping of the tu

89 gical manipulation may produce qualitatively distinct effects depending on the temperature.

90 nate binding at several positions suggesting distinct effects of the two substrates.

91 itis (median age, 4 months), we identified 4 distinct endotypes-mainly characterized by RV species, m

92 Although we experience thousands of distinct events on a daily basis, relatively few are com

93 In addition, in 47 distinct eyes, 4181 spectral-domain OCT slices were retr

94 also whether covert facial mimicry involves distinct facial muscle activation patterns across muscle

95 ch from producing motor neurons to OPCs with distinct fates is poorly understood.

96 crystallography, Philips et al. explore the distinct features of PD-L2 and identify a specific evolu

97 Here, we show that SOX11 confers distinct features to ER-negative DCIS.com breast cancer

98 line-active and soma-specific promoters have distinct features.

99 uilt from proteins that carry two spectrally distinct fluorescent labels.

100 he flash and camera to image the signal from distinct fluorophore-labeled probe types in a biplexed N

101 th 7 nodes by site-specifically anchoring of distinct fluorophores onto a structure.

102 es: Objects can be actuated from a distance, distinct frequencies can be used to actuate and control

103 tion reveals an additional bacterial pathway distinct from archaeal methanogenesis.

104 lastomycosis were caused by species that are distinct from B. dermatitidis Increasing clinical awaren

105 amyloid assembly process, results which are distinct from beta2m oligomers formed at low pH.

106 We showed that lncRNAs are distinct from both protein-coding transcripts and genomi

107 aerobic glycolysis is a process functionally distinct from conventional glucose metabolism and leads

108 ue set of cytogenetic and molecular features distinct from de novo AML.

109 is physically close on chromosome 5, but is distinct from DOG1.

110 ring observation, M1 population activity was distinct from execution, and more closely aligned to NoG

111 However, XPRT oligomeric interaction is distinct from HPRT in that XPRT forms a symmetric dimer

112 Bovine luteal LDs are distinct from LDs in other bovine tissues, including fol

113 The urinary microbiome is distinct from nearby sites and unrelated to stool microb

114 ttitudes represent something psychologically distinct from other constructs (e.g., strong but nonmora

115 V infection and pathogenesis via a mechanism distinct from other factors that modulate CoV entry.IMPO

116 in all tissues, had a mature phenotype and, distinct from other NKT cells, expressed almost no ThPOK

117 e analysis indicating an evolutionary origin distinct from Southeast Asia.

118 in tomato and two other Solanaceae crops is distinct from that in Arabidopsis thaliana.

119 B cells derive from a developmental program distinct from that of conventional B cells, through B ce

120 eavage but with a target sequence preference distinct from that of RuvC, highlighting a unique role o

121 sly observed to adopt a mitotic organisation distinct from that of surrounding mouse DNA.

122 vary microbiome of 4-y-old children is still distinct from that of their caregivers.

123 structures on the millimeter scale, which is distinct from that on a conventional planar surface with

124 ssociated with a biochemical mineral pattern distinct from that typically observed in CKD-mineral and

125 a population of glycinergic cells in the VCN distinct from the D-stellate cell.

126 gratory cell population with a transcriptome distinct from the previously defined T1- and T2-ProSG st

127 l DNA (RDN) condenses to a thin loop that is distinct from the rest of the chromosomes.

128 t and leads to orbital interactions that are distinct from those available to the linear configuratio

129 o alkenes would produce alkylarenes that are distinct from those formed by acid-catalysed processes.

130 ues found in the MMP-targeting sets that are distinct from those in the reference sets.

131 tor (CAR) T cell therapy works by mechanisms distinct from those of other MM therapies and involves t

132 signatures in Chinese patients were markedly distinct from those of Western cohorts: specifically, 41

133 filaments were identical between cases, but distinct from those seen in Alzheimer's disease, Pick's

134 e results confirm that KHARON assembles into distinct functional complexes and that the subpellicular

135 Saccharibacteria clades G3 and G6, which had distinct functional repertoires compared to other oral S

136 segregated by appropriate breeding, implying distinct functions in karyokinesis and cytokinesis.

137 ntly recruited MPs after injury and unveiled distinct functions of these subsets, with recruited MPs

138 hat precise gene editing to correct multiple distinct gene variants could be highly efficacious if de

139 an S-locus "supergene" consisting of several distinct genes that determine different traits of the sy

140 stematic and comprehensive analyses revealed distinct genetic architecture of human NP and AF compart

141 gically relevant because they appear to have distinct genetic architecture.

142 isolated from 2015 to 2017 constituted >= 35 distinct genotypes, representing high levels of genetic

143 Females from three distinct genotypic backgrounds were left unmated or sing

144 t the role of biofilms in creating spatially distinct geochemical niches that enable the co-existence

145 hen the groups of samples being compared had distinct global within-group variability.

146 Starch granules are composed of two distinct glucose polymers - amylose and amylopectin.

147 e idea that Npas1(+)-Nkx2.1(+) neurons are a distinct GPe neuron subclass.

148 rown livers, liver colours 5 and 6, formed a distinct group.

149 airs revealed the synchronized occurrence of distinct groups of spikelets; their rate and distributio

150 rtoire of known HBoV1 variants by cloning 29 distinct HBoV1 capsid sequences from primary human sampl

151 , we evaluated 231 individuals harboring 105 distinct heterozygous NFKB1 variants.

152 nerability to tau pathology, account for the distinct histopathological morphologies, biochemical com

153 ensing system and have been proposed to have distinct, if uncertain, roles in protein and amino acid

154 RNA-seq tape strip profiling detected distinct immune and barrier signatures in lesional and n

155 e related to different antigens that trigger distinct immune-inflammatory reactions.

156 COVID-19 ARDS exhibits a distinct immunologic profile in the lungs, with a deplet

157 tion signals in the nucleocapsid protein and distinct inserts in the spike glycoprotein that appear t

158 Asymmetry also induces distinct inter-subunit interactions around the ring, sug

159 were used as model cell-based carriers with distinct intracellular composition and curcumin was a mo

160 P cell fates are specified and maintained by distinct intrinsic factors.

161 e, we describe the crystal structures of two distinct isoforms of ligand-free human karyopherin RanBP

162 ltiple RPPA-based approaches operated across distinct laboratories, we characterised a range of human

163 Remarkably, its electronic state shows distinct Landau quantization on application of a magneti

164 Seven genetically distinct LASV lineages have been identified.

165 the external environment using functionally distinct layers, cell types and extracellular matrix.

166 isms by which plants coordinately respond to distinct levels of water deficits (e.g., mild, moderate

167 Currently, viruses of two distinct lineages of parvoviruses (PVs, family Parvoviri

168 cterium Vibrio cholerae consist of dozens of distinct lineages, with primarily (but not exclusively)

169 Interestingly, many combinations resulted in distinct lipid nanostructures.

170 ense oligonucleotide (ASO) with a variety of distinct lipophilic moieties like fatty acids and choles

171 like protein 2 (MKLP2) in targeting to these distinct localizations.

172 A plethora of genetic associations between distinct loci and various traits have been successfully

173 gene combinations that were associated with distinct MDS/MPN subtypes and that were mutually exclusi

174 -based decision-making tasks which yield ten distinct measures.

175 We identify distinct mechanisms of resistance, in which HUWE1 loss i

176 essential drugs act through overlapping and distinct mechanisms to potentiate inhibitory signalling

177 oceeding are reported, which proceed via two distinct mechanistic pathways: enantioselective acyl tra

178 Our results demonstrate that distinct membrane domains can integrate a common signal

179 conventional glucose metabolism and leads to distinct metabolic requirements and biological functions

180 oral inflammatory disease in mice harboring distinct microbiomes.

181 synthesise current knowledge regarding these distinct microplastic-associated bacterial communities a

182 that consists of three combined regions with distinct microstructures and growth factor types.

183 We also found that two distinct migratory strategies (e.g. some individuals alw

184 ory role of cytosolic LPS, our data reveal a distinct mode of LPS action that, through the disruption

185 mational changes within RRS1 that results in distinct modes of derepression of the complex by PopP2 a

186 equencies can be used to actuate and control distinct modes with minimal interference, and significan

187 olic cooperation but low competition reveals distinct modules of bacterial interactions.

188 erved plant analogs of animal complexes with distinct molecular assemblies, including a megadalton-sc

189 e been puzzling because the compounds target distinct molecular receptors in the brain.

190 ith normal intestinal function but also show distinct molecular signatures indicative of enhanced fat

191 We conclude that BPH consists of distinct molecular subgroups, with potential for subtype

192 We show that the distinct molybdenum isotopic compositions of CAIs cover

193 ntral building blocks in the biosynthesis of distinct monocot diterpenoids.

194 on activity in vitro and is localized within distinct motile puncta in L. japonicus root hairs and in

195 fferently to physiological plasticity and to distinct motor learning tasks, which suggests they repre

196 Here, we examine how the distinct motor programs of the nematode C. elegans are c

197 We show that distinct multimode patterns of light can be projected fr

198 n AD development of NC mice, we employed two distinct murine models of iNKT cell over-representation:

199 system we produced a protein containing two distinct ncAAs at the first and second positions, an ini

200 LCA revealed three distinct NERD subphenotypes.

201 assembly, and determined that a dynamically distinct network of 9 +/- 1 water molecules is present w

202 We found that distinct neural populations respond preferentially to VO

203 Diverse sensory neurons exhibit distinct neuronal morphologies with a variety of axon te

204 ol the diversification of motor neurons into distinct neuronal subsets by ensuring the maintenance of

205 During granulopoiesis in the bone marrow, distinct neutrophil granules are successively formed.

206 the structure of this carotenoprotein in two distinct oligomeric states.

207 ohistochemistry to identify a phenotypically-distinct, osteogenically-committed BMSC subset in human

208 The study also revealed distinct parallels to photoredox-catalyzed reactions, in

209 f the same oncogene arising in parallel from distinct parental haplotypes.

210 lit ligands are expressed in overlapping and distinct patterns in both endocrine and non-endocrine ti

211 gnetic resonance imaging (fMRI) revealed two distinct patterns of activity, one in anterior insula an

212 that Akt allosteric inhibitor MK2206 drives distinct PH domain structural changes compared to baseli

213 ng cells, clearly delineating two temporally distinct phases of liver recovery.

214 plasticity allows genomes to encode multiple distinct phenotypes that can be differentially manifeste

215 e of fluorinated therapeutic candidates with distinct physicochemical properties relative to the orig

216 chain (MHC) isoforms alone account for these distinct physiological properties.

217 Although there are several distinct PIV serotypes, few studies have compared the cl

218 In conclusion, our results reveal distinct PKC-dependent regulation of CF transdifferentia

219 in the same environment, even at temporally distinct points.

220 We discovered a distinct population of GABAergic neurons activated by GA

221 122 studies providing estimates for 130 distinct populations matched the inclusion criteria.

222 We demonstrated that in these T-ALLs and in distinct populations of normal developing thymocytes, GC

223 n analyses of these two types of QTLs reveal distinct positions of enrichment at the central transcri

224 sign experiments for which the theories make distinct predictions.

225 d that ON and OFF SACs are transcriptionally distinct prior to their segregation, dendritic outgrowth

226 daptation, but also show that additional and distinct processes are involved in consolidating and imp

227 ker expression stratified the cohorts into 3 distinct prognostic groups.

228 Yet, stimuli have distinct properties: incentive stimuli orient the attent

229 ene and protein markers for three temporally distinct ProSG cell subsets, including a migratory cell

230 abled discovery of novel inhibitors for many distinct protein targets of therapeutic value.

231 ic T cells, we carried out a screen of 3,724 distinct proteins covering 95% of Mtb protein-coding gen

232 findings reveal a dynamic interplay between distinct RBPs and alternative 5' UTRs in neuronal develo

233 nduced signaling in this system involves two distinct receptor-G protein complexes, a conventional te

234 of the plasmid on chlamydial colonization in distinct regions of gastrointestinal tract.

235 ot mutually exclusive, and the proteins bind distinct regions of SidI.

236 amics of spindle orientation in mechanically distinct regions of the fly notum, we find that the abil

237 ntained in the adult brain of lungfishes, in distinct regions of the telencephalon (pallium and subpa

238 ish that reachable-scale environments have a distinct representational signature from both scene and

239 iability of many behavioral measures and the distinct response processes involved in the two measurem

240 These distinct responses emerge from different combinations of

241 by two mechanoreceptor subtypes that exhibit distinct responses to tactile stimuli.

242 sured before and during exposure demonstrate distinct responses to the four tested alcoholic vapors (

243 y cells exhibit a variety of morphologically distinct responses to their environments that manifest i

244 Population groups show distinct risk factor trend differences, indicating the n

245 conserved chromatin remodeling factor has a distinct role in anti-microbial defense.

246 over, direct and indirect pathways also play distinct roles in timing.

247 fferent locations throughout the body, serve distinct roles, and are activated by a variety of signal

248 lls in assemblages differentiate and perform distinct roles.

249 -5 systems have been shown to each secrete a distinct set of substrates, including PE and PPE familie

250 lusion that polarized cholangiocytes release distinct sEV pools to mediate communication via their ap

251 tributed Coulter sensors designed to produce distinct signal waveforms and performed experiments with

252 o elongation dynamics, produce qualitatively distinct signatures, which can further be used to discer

253 ommunication between protein interactions at distinct sites.

254 h convergent repression of Bim expression by distinct SMS- and MYC-mediated signaling pathways.

255 separation and imaging of lipid isomers with distinct spatial distributions were performed using tiss

256 compared to monoculture plots, as well as a distinct species composition between plot types.

257 oid fibrils in some important ways but are a distinct species.

258 not encoded with the same fidelity by these distinct spectral components.

259 d achieved specific glycogen mapping through distinct spectral identification.

260 lace cells and entorhinal grid cells exhibit distinct spike patterns in different environments, a cir

261 heath based ion acceleration and creates two distinct stages in the acceleration process associated w

262 similar CDC42 splice variants in regulating distinct stages of neurogenesis.

263 Our study may point to distinct stages of progression of COVID-19 lung disease

264 round 8,500 operations while reusing only 22 distinct steps in 10 unique modules, with the code able

265 Arfs control distinct steps in intracellular membrane traffic, and on

266 nce has demonstrated that humans exhibit two distinct strategies when learning in complex environment

267 However, it is unclear how distinct structural features of the two PA2G4 isoforms t

268 The High Pressure Quenched glasses have a distinct structure and properties.

269 Thus, the activation of acetate in distinct subcellular compartments provides plants with t

270 of molecularly, functionally, and spatially distinct subdomains of the plant TGN and suggest that fu

271 ation signatures partitions POLE tumors into distinct subgroups dependent on the nature of the POLE a

272 cell pool, a comprehensive understanding of distinct subpopulations and their functional relevance i

273 Two distinct subsets of ILC2s have been described: steady-st

274 P2ry1-Pet1 DR neurons - the most molecularly distinct subtype - possess unique efferent projections a

275 f developing early preeclampsia and indicate distinct subtypes of pathophysiology and clinical morbid

276 GBM can be subcategorized into four distinct subtypes; tumors that shift towards the mesench

277 cation of cancer patients into subtypes with distinct survival and therapy response profiles.

278 H7 bacteriophage vB_EcoM_CBA120 encodes four distinct tailspike proteins (TSPs).

279 ol, but the consequences of these changes on distinct targets such as astrocytes, which exhibit norep

280 h are pioneer factors with common as well as distinct targets.

281 ne the potential mechanisms underlying these distinct temporal profiles, we developed a reduced spiki

282 A distinct TEMRA CD8(+) T cell subpopulation was identifie

283 vels reflect cellular states associated with distinct therapeutic responses.

284 lites that correctly identified TB status at distinct times during treatment.

285 The authors revealed a distinct tolerant B cell phenotype possessing the abilit

286 s and 30 neuronal fiber tracts including six distinct tracts between the optic lobes and the cerebrum

287 Together, our findings demonstrate that distinct transcriptional and signaling mechanisms contro

288 GSi-responder patients were characterized by distinct transcriptomes overlapping with previous hepato

289 ation in numerous archived FFPE samples from distinct tumor types.

290 , having topographically and morphologically distinct tumour foci.

291 nclusion, the structure of RNF213 uncovers a distinct type of an E3 enzyme, highlighting the growing

292 the state-space locations were predictive of distinct types of errors: failures-to-stop, failures-to-

293 odology is demonstrated by the design of two distinct types of reactions: Giese-type addition and Co/

294 of 20 neurons that fall into 14 anatomically distinct types.

295 t the stripe is shaped by the interplay of 2 distinct underlying molecular processes.

296 osed of several segments, each packaged in a distinct viral particle.

297 The establishment of distinct viral strains and their variable circulation pa

298 y to induce cellular senescence, affording a distinct way to control joint inflammation and arthritis

299 rs influence memory performance but do so in distinct ways.

300 cate that mutations can affect the length in distinct ways.