ライフサイエンスコーパス: divalent cation

1 ed in binding of the catalytically essential divalent cation.

2 r Mg(2+) or Mn(2+) capable of serving as the divalent cation.

3 d dephosphorylation in reactions requiring a divalent cation.

4 uclease depending on the nature of the added divalent cation.

5 d sequesters a single PKR in the presence of divalent cation.

6 influence calcium diffusion because it is a divalent cation.

7 modifications, target types, reporters, and divalent cations.

8 was also activated by Na(+)and inhibited by divalent cations.

9 ly important for cell adhesion in niche with divalent cations.

10 f this mode of detachment in the presence of divalent cations.

11 s ) with to near-zero contact angles without divalent cations.

12 out the effects of environmentally important divalent cations.

13 ementing medium with zinc but not with other divalent cations.

14 tein ZnuA binds zinc but does not bind other divalent cations.

15 ically used opioid drugs, are monovalent and divalent cations.

16 re decreased by treatment with a chelator of divalent cations.

17 that their fusion efficiency is increased by divalent cations.

18 esidues 55-60, and binds RNA oligos, but not divalent cations.

19 identical with that previously observed for divalent cations.

20 the presence of Zn(2+) than in water free of divalent cations.

21 oop complexes in the presence and absence of divalent cations.

22 nce that is relaxed by chelation of residual divalent cations.

23 ically stable in solution in the presence of divalent cations.

24 by reoccupying the buried site with various divalent cations.

25 nt carried by a wide range of monovalent and divalent cations.

26 domains of calreticulin that are impacted by divalent cations.

27 verse transcription requires the presence of divalent cations.

28 otetrameric enzyme activated by a variety of divalent cations.

29 nce of very high concentrations of competing divalent cations.

30 performed in the presence of monovalent and divalent cations.

31 when performing RED using streams containing divalent cations.

32 erved CAP tetrad and is incapable of binding divalent cations.

33 lent cations up to 5 times more rapidly than divalent cations.

34 .7 muM), and selective for Fe(2+) over other divalent cations.

35 -347) downstream of S6 reduces inhibition by divalent cations.

36 As for the ability of the divalent cations (1-17.5mM) to induce the precipitation

37 ene family known to import Mn, Zn, and other divalent cations across the plasma membrane.

38 ntrations of Ca(2+) and Mg(2+), showing that divalent cations act as crosslinkers.

39 KO mice are more sensitive to inhibition by divalent cations, although they respond normally to cyto

40 Both structures reveal that the divalent cation and cholesterol binding sites are connec

41 a binding site for one of three betaI domain divalent cations and a unique beta6-alpha7 loop conforma

42 ing a common polyacrylic acid hydrogel, with divalent cations and acid as representative stimuli, we

43 Co-crystals with divalent cations and ATP reveal the molecular mechanism

44 Divalent cations and heavy chain 2 are essential co-fact

45 PhoQ activity is repressed by divalent cations and induced in environments of acidic p

46 t mitochondrial iPLA(2)gamma is activated by divalent cations and inhibited by acyl-CoA modulating th

47 ulation of integrin-binding affinity by both divalent cations and intracellular signal inhibition.

48 CcLpxI is stimulated by divalent cations and is inhibited by EDTA.

49 cific binding of AMP to Lpp was resistant to divalent cations and salts, which were able to inhibit t

50 els with integrin activation in solutions of divalent cations and shift dramatically upward to hypera

51 basal levels with activation in solutions of divalent cations and shift dramatically upward to hypera

52 of conformational changes, and the impact of divalent cations and tensile forces.

53 water molecules mediate contacts between the divalent cations and the C-tetrad, allowing Ba(2+) ions

54 steric sites on CHRMs respond differently to divalent cations and the effects of allosteric modulatio

55 sion assays demonstrated parallel effects of divalent cations and the FAK inhibitor on cell adhesion.

56 ed up to 1,300-fold by low concentrations of divalent cations and the polyamine spermine.

57 ze DNA origami against low concentrations of divalent cations and the presence of nucleases.

58 ponent system, which detects and responds to divalent cations and to antimicrobial peptides, and can

59 Like other 5'-nucleotidases, S5nA requires divalent cations and was active in the presence of Mg(2+

60 gly inhibited in the formulations containing divalent cations and/or CMCS as excipients, although spe

61 ionality in a reaction that is stimulated by divalent cations, and both nucleases are inhibited by th

62 nduced in environments of acidic pH, limited divalent cations, and cationic antimicrobial peptides (C

63 C2A to 1.9 angstrom resolution bound to two divalent cations, and compare its three-dimensional stru

64 t, channel activations by capsaicin, low pH, divalent cations, and even heat are mostly intact in mut

65 Reactions do not require divalent cations, and have limited dependence on monoval

66 Overall, pH, divalent cations, and NOM can play complex roles in the

67 otide-dependent RCK domains, indicating that divalent cations are a general cofactor in the regulator

68 In particular, divalent cations are coordinated by the gamma-phosphates

69 ination between the phosphate groups and the divalent cations are discernible even at very low Mg(2+)

70 The role of different divalent cations are discussed in relation to these two

71 For ribozymes, divalent cations are known to be more efficient than mon

72 ence, specific interactions between VIFs and divalent cations are likely to be an important mechanism

73 pproximately 1.5 mm Our results suggest that divalent cations are not SLO2 pore blockers, but rather

74 of the ion atmosphere content indicates that divalent cations are preferentially lost over monovalent

75 Divalent cations are required for activity, whereas mono

76 e in the preQ1 class I (preQ1-I) riboswitch, divalent cations are required for high-affinity binding.

77 Divalent cations are shown here to crossbridge polyanion

78 Divalent cations are used by protein kinases to both sta

79 In addition, NMCCs do not permeate divalent cations, are inhibited by calcium ions, and dem

80 pplied stress using a theory that treats the divalent cations as crosslinkers: at low stress, the beh

81 inate can form gel particles in contact with divalent cations as found in seawater.

82 n betaA domain of the beta-subunit through a divalent cation at the metal ion-dependent adhesion site

83 h reveals the presence of a binding site for divalent cations at a crystal contact.

84 stances might represent peculiar features of divalent cations at the ferroxidase site.

85 ve electrostatic trap, with a preference for divalent cations, at the luminal entrance.

86 Divalent cations behave as effective cross-linkers of in

87 These results show that targeting a divalent cation binding residue can enable selective inh

88 inding cavity; the other is close to a known divalent cation binding site in other pentameric ligand-

89 A common divalent cation binding site, distinct from the position

90 rospects for extending the method to predict divalent cation binding to nucleic acids.

91 he remote site in solution is specific for a divalent cation, binding both calcium and magnesium with

92 eals the molecular details of three distinct divalent cation-binding sites identified through electro

93 us-ms time scale and deactivates both of the divalent cation-binding sites of the cTnC C-domain.

94 RSV transcription system suggested that the divalent-cation-binding domain of actin is critically ne

95 Divalent cations (both ion channel and intracage binding

96 roup concentration and resultant reduced NOM-divalent cation bridging.

97 Divalent cations Ca(2+) and Ba(2+) permeate TRPV6 pore a

98 ange County Groundwater Basin sediments, the divalent cations Ca(2+) and Mg(2+) are critical for limi

99 dipeptides, and their interactions with the divalent cations Ca(2+), Ba(2+), Sr(2+), Cd(2+), Pb(2+),

100 critical deposition concentration (CDC) for divalent cation (Ca(2+) and Mg(2+)) were more than 31-fo

101 , the NSP4 VPD showed similar conductance of divalent cations (Ca(2+) and Ba(2+)) as monovalent catio

102 The co-occurrence of divalent cations (Ca(2+) and Mg(2+)) and Cr(VI) resulted

103 nts demonstrated the importance of including divalent cations (Ca(2+) and Mg(2+)) in the suspension m

104 cs in the presence of monovalent (Na(+)) and divalent cations (Ca(2+)) show that attachment efficienc

105 In the presence NOM and divalent cations (Ca(2+), Mg(2+)), GO aggregates settle

106 ylmaleimide, propranolol, phenylglyoxal, and divalent cations (Ca(2+), Mn(2+), and Zn(2+)).

107 he alkali metal cations, Na(+) and K(+), the divalent cations, Ca(2+) and Mg(2+), and the trace metal

108 t immobilized alphaLbeta2 in environments of divalent cations (Ca2+, Mg2+, and Mn2+) and demonstrate

109 2 on microspheres in millimolar solutions of divalent cations (Ca2+, Mg2+, Mn2+).

110 ermination by DPA with its associated Ca(2+) divalent cation (CaDPA) but germinated better than wild-

111 Here we show that the divalent cations calcium, strontium, and magnesium can p

112 proof of concept, we show that SS-31 alters divalent cation (calcium) distribution within the interf

113 A divalent cation (calcium), a polyion (protamine), and an

114 * conformer is stabilized by a high-affinity divalent cation capable of inner-sphere coordination, su

115 ir of dimer-related tyrosines, together with divalent cations, catalyse G-segment cleavage.

116 asing salt concentration and introduction of divalent cations caused aggregation of SWNT clusters by

117 otoxin, as well as Ca(2+) free solutions and divalent cation Cav channel blockers, eliminate the outw

118 riotoxin (10 mum), Ca(2+) free solutions and divalent cation Cav channel blockers.

119 in member 7 (TRPM7) and member 6 (TRPM6) are divalent cation channel kinases essential for magnesium

120 ch NS1 monomer, and tubules are disrupted by divalent cation chelation and restored by cation additio

121 The divalent cation chelator EDTA, which disrupts heterodime

122 can be recapitulated by acute treatment with divalent cation chelators, including those specific for

123 ulations also revealed the importance of the divalent cation cloud surrounding exposed phosphates on

124 Ligases react with ATP or NAD(+) and a divalent cation cofactor to form a covalent enzyme-(lysi

125 This study suggested that divalent cation complexation with carboxylate groups in

126 Changing divalent cation composition affects these coefficients,

127 olutions containing 20 mg C/L increased with divalent cation concentration until reaching a critical

128 re lower than in CaCl(2) solution at a given divalent cation concentration.

129 folding times and calibrated monovalent and divalent cation concentrations.

130 l Melastatin family of ion channels and is a divalent cation-conducting ion channel fused with a func

131 ing Hg uptake pathways; we propose that base divalent cations contribute to hamper net Hg(II) accumul

132 tion between DNA and RNA substrates based on divalent cation coordination and generates a positively

133 nsferases, essential for enzyme activity and divalent cation coordination, we found that a DxN motif

134 The LPS layer is rigid and stabilized by divalent cation cross-links between phosphate groups on

135 e presence of Ca (and most probably of other divalent cations), Cs accessibility to exchange position

136 This interaction is divalent cation-dependent and overlaps with the binding

137 gulatory mechanism involved operates through divalent cation-dependent conversion between the non-tub

138 ate at position Asp-50 was indispensable for divalent cation-dependent gating of Cx30 hemichannels, s

139 Cell interactions were divalent cation-dependent, indicating integrin dependenc

140 -T3 and beta4GalNAc-T4 to terminal GlcNAc is divalent cation-dependent.

141 ssical transcription factor for the virus by divalent-cation-dependent binding to the viral template

142 We investigated the role of reverse divalent cation diffusion in forward osmosis (FO) biofou

143 airing with template and mapped movements of divalent cations during preinitiation.

144 that allow for influx or efflux of mono- or divalent cations (e.g., Ca(2+)) important for synaptic t

145 ters can destabilize the nanoparticles, with divalent cations (e.g., Ca(2+), Mg(2+)) being more influ

146 +) binding sites are collapsed and devoid of divalent cations (E2-PLB).

147 n demonstrating that both ionic strength and divalent cations effect a decrease in the Fe(II)-binding

148 Third, divalent cation effects on the 5'-exonuclease and the en

149 we found that ranolazine and elevated serum divalent cations eliminate myotonia by inhibiting AfD an

150 Consequently, at neutral pH the presence of divalent cations enhanced the aggregation of HAdV as wel

151 content of calreticulin are impacted by the divalent cation environment, with the ER range of calciu

152 riencing low cytosolic magnesium (Mg(2+)), a divalent cation essential for ribosome stabilization and

153 site model (RISM), which allows us to treat divalent cations explicitly while keeping the implicit s

154 ed a variant of ANGPTL4 that is dependent on divalent cations for its ability to inhibit LPL.

155 -1) using a preconditioning step to exchange divalent cations for monovalent ions, 0.2% carboxymethyl

156 If the currents observed in divalent cation-free Ringer's solution were due to Cx46

157 Chelating divalent cations from the culture medium abolished these

158 in alpha1 I domain induced by the binding of divalent cations, full-length type IV collagen, or a fun

159 In contrast, in the presence of a divalent cation, GTPgammaS adopts an extended conformati

160 Divalent cations have long been known to neutralize and

161 We show that LTA is needed for divalent cation homoeostasis and that its absence has se

162 ective ion removal, the selective removal of divalent cations (i.e., hardness) over monovalent cation

163 A decrease in pH and the presence of a divalent cation improved the intramolecular electron tra

164 action, explain the role of the noncatalytic divalent cation in 6 RdRp, and pinpoint the previously u

165 guing because magnesium is the most abundant divalent cation in all living cells.

166 Magnesium (Mg(2+)), the most common divalent cation in living cells, plays crucial roles in

167 Mg(2+) is the most abundant divalent cation in metazoans and an essential cofactor f

168 the present study, we have investigated how divalent cations in concert with the chondroitin sulfate

169 addition, we discover an important role for divalent cations in determining the frequency and locati

170 m by which monovalent cations substitute for divalent cations in hammerhead catalysis remains unclear

171 250) in spacegroup I41 and the other without divalent cations in spacegroup P6122.

172 The protein does not require divalent cations in the active site for catalytic activi

173 s distorted (beta/alpha)(8)-barrels with two divalent cations in the active site.

174 +) directly and specifically substitutes for divalent cations in the hammerhead active site.

175 gluconolactone showed a k(cat) preference of divalent cations in the order Zn(2+) > Mn(2+) > Ca(2+) >

176 ding Zn(2+), suggesting a regulatory role of divalent cations in tubule formation.

177 ated metalloprotein with the ability to bind divalent cations including Co(2+), Zn(2+), Fe(2+), and N

178 F-SCAN channels permeate both monovalent and divalent cations, including Ca(2+), and exhibit synergis

179 ions was not re-established, indicating that divalent cations increase the energy barrier between tra

180 4 and/or i,i+7 intervals, which by chelating divalent cations induce and stabilize helical conformati

181 0 (KOCx50) mouse lenses, removal of external divalent cations induced a macroscopic current composed

182 al of the Mg(2+) found in plasma and because divalent cations influence the conformation and affect f

183 We use "wash-in" experiments to show that divalent cations inhibit rescue during depolymerization,

184 , POPC only interacts weakly with Ca(2+); 5) divalent cations interact with lipids in a lipid- and io

185 te linkage, monodentate or bidendate, to the divalent cation is a useful parameter for tuning the tra

186 physiological levels of Mg(2+) because this divalent cation is critical for the stabilization of mem

187 e primarily bound to the C-terminus, while a divalent cation is located at the catalytic site, acting

188 -order in-line rate constant with respect to divalent cations is >200 times greater with Fe2+ than wi

189 To investigate whether inhibition by divalent cations is conserved in an invertebrate SLO2 ch

190 The affinity of the remote site for divalent cations is in the low millimolar range and rema

191 Improvement in bioavailability of divalent cations is needed.

192 lectrostatic interactions with intracellular divalent cations is tested here using lipid monolayer an

193 els, with few showing the ability to conduct divalent cations, like calcium (Ca(2+)).

194 is inhibited for activation by acidic pH and divalent cation limitation.

195 identified so far depend on the presence of divalent cations, LtpM is active in their absence.

196 Three divalent cations (M(++)=Zn(++), Co(++), Ni(++)) were eva

197 significantly lower binding affinity for the divalent cations magnesium and strontium.

198 The sensitivity toward divalent cation-mediated gating differed between small a

199 ex interacts significantly stronger with the divalent cation Mg(2+), despite their identical total ch

200 complexes in chloroform, especially for the divalent cation Mg(2+).

201 Moreover, we demonstrate that the divalent cations Mg(2+) and Ca(2+) can replace the role

202 In this study, we investigate the effects of divalent cations (Mg(2+) and Ca(2+)) on RED and demonstr

203 On an aqueous subphase containing divalent cations (Mg(2+), Ca(2+), Zn(2+), Sr(2+), or Cd(

204 CD spectroscopic studies of apo (absence of divalent cations)-, Mg(2+)-, and Ca(2+)/Mg(2+)-bound sta

205 The presence of the divalent cation, Mg(2+), essential for chromatin compact

206 ve sites, in the presence and absence of the divalent cation, Mg(2+).

207 ly upon addition of small amounts of certain divalent cations (Mg2+, Ca2+).

208 sponse to manipulations to the extracellular divalent cation milieu.

209 identified the fractional surface density of divalent cations (n(s2))as the parameter which best expl

210 t pH 7 and at the presence of monovalent and divalent cations (Na(+), K(+), Mg(2+)(,) and Ca(+2)).

211 Divalent cations neutralized/shielded virus surface char

212 t of selectivity differences among different divalent cations observed for each Ca(2+)-binding site.

213 romatin to a greater extent than the natural divalent cation of the cell, magnesium ion (Mg(2+)).

214 Divalent cations of larger ionic radius than Sr(2+) are

215 Divalent cations of two alkaline earth metals Ca(2+) and

216 reviously investigated, beneficial effect of divalent cations on the activity of CDH was also present

217 changes on MLOs, we studied the influence of divalent cations on the physical and chemical properties

218 en the influent water was at pH 5, contained divalent cations or 50 mM NaNO3, silver concentrations w

219 er able to self-associate in the presence of divalent cations or under heat shock.

220 was increased to favor the permeation of one divalent cation over the other, a similar increase in ce

221 TRPM7's kinase activity and selectivity for divalent cations over monovalent cations were dispensabl

222 nity is strongly affected by the presence of divalent cations, owing to their complexation with the f

223 Aided by divalent cations, P4 is poised to act as a "screw cap" o

224 Zinc, a divalent cation packaged in synaptic vesicles along with

225 DNA duplexes and highlights the unique role divalent cations play in differential stabilization of c

226 ional change induced in Delta50 lamin A with divalent cations plays a regulatory role in the posttran

227 We show that: counterions, especially divalent cations, predominantly condense around the nucl

228 results suggest that gp32 and UvsY may alter divalent cation preference and facilitate the formation

229 Divalent cations preferentially bind to DNA over monoval

230 Divalent cations present in SP had little effect on the

231 ibosome is not exchangeable with surrounding divalent cations, presumably because those ions are tigh

232 that surprisingly, MdfA catalyses efflux of divalent cations, provided that they have a unique archi

233 ward current activated by withdrawal of bath divalent cations, representing SOCE.

234 eports that CT296 has properties shared with divalent cation repressors such as Fur.

235 0.03 and -0.52 +/- 0.01 with monovalent and divalent cations, respectively, and these results help c

236 in aggregation and minor coalescence, while divalent cations resulted in extensive coalescence.

237 Divalent cations reversed this LCA-induced switch to cha

238 e tip into a solution containing a dissolved divalent cation salt to form a solid gel; (ii) the resul

239 The effect of addition of divalent cation salts CaCl(2), MnCl(2) as well as carbox

240 nticity of the ligand Asp/Glu can modify the divalent cation selectivity at MIDAS and hence integrin

241 ulated by the intracellular concentration of divalent cations sensed by a large structure in the BK c

242 ulent in mice, indicating that acidic pH and divalent cation sensing by PhoQ are dispensable for viru

243 The interaction was affected in a pH- and divalent cation-sensitive manner.

244 fic properties in mind, we characterized the divalent cation-sensitive permeation pathway in primary

245 Mg(2+) unbinding at the divalent cation sensor triggers a conformational change

246 rge pH gradients, high salinity and abundant divalent cations should preclude vesicle formation.

247 frigidimarina cultured in 1/2 MB and LB with divalent cations shows that a maximum current output can

248 We show here that divalent cations slow the activation rate of two EAG fam

249 Mephenesin or high divalent cation solutions were used to limit oligosynapt

250 FrvA functions in vitro as a divalent cation specific ATPase most strongly activated

251 hich PQ is transported by DAT: In its native divalent cation state, PQ(2+) is not a substrate for DAT

252 spatially distinct site for reabsorption of divalent cations such as Ca(2+) and Mg(2).

253 Divalent cations such as calcium can cause clustering of

254 In immune cells, divalent cations such as calcium, magnesium, and zinc ha

255 zinc ions is readily exchangeable with other divalent cations such as manganese, which strongly stimu

256 molar concentrations of monovalent cations, divalent cations such as Mg(2+) are required for efficie

257 Electrochemical storage systems that utilize divalent cations such as Mg2+ can improve the volumetric

258 Interestingly, other divalent cations such as Zn(2+), Fe(2+), Co(2+), and Mn(

259 oQ/PhoP two-component system is repressed by divalent cations, such as Mg(2+) and Ca(2+), in the grow

260 Divalent cations, such as zinc and copper, have alloster

261 nhances its activity, which was inhibited by divalent cations, such as Zn2+ and Mn2+.

262 nd dendritic cells (DCs) is known to require divalent cations, suggesting involvement of C-type lecti

263 ed by the gate electrode are impacted by the divalent cation-surface interactions, limiting modulatio

264 e only after the ES complex captures a third divalent cation that is not coordinated by the enzyme.

265 gh, we found that SLO2.2 is inhibited by all divalent cations that activate SLO1, with Zn(2+)being th

266 han dsDNA, is precipitated by alkaline-earth divalent cations that are unable to condense dsDNA.

267 of SLO2 channels in mammals andDrosophilaby divalent cations that have second messenger functions ma

268 e for radial shear assays in the presence of divalent cations that increase integrin-ECM affinity.

269 Our results imply that it is the removal of divalent cations that makes reservoir rocks more hydroph

270 Upon complexation with a divalent cation, the accessible conformational space shr

271 e of the enzyme with Ca(2+), Zn(2+) or other divalent cations, thus providing greater catalytic power

272 ore sensitive to the inactivating effects of divalent cations, thus, in the presence of Mg(2+) , ATP

273 t these sites alter the ability of different divalent cations to activate the channel.

274 can be induced by the addition of mono- and divalent cations to aqueous U60 solutions.

275 Issues such as the effect of mono- and divalent cations to hybridization and the mechanism of t

276 inner shell and outer shell coordination of divalent cations to phosphate groups, which we demonstra

277 ported to exhibit functional properties of a divalent cation transcription repressor (DcrA), with sim

278 It remains unclear how TRPM6 affects divalent cation transport and whether this involves func

279 ent-selective Neosepta CMS is known to block divalent cations transport and can therefore mitigate re

280 ly 11 member 1 (SLC11A1; formerly NRAMP1), a divalent cation transporter crucial to host defense agai

281 nexin SNX3, and a recycling signal from the divalent cation transporter DMT1-II.

282 permeation properties to both monovalent and divalent cations under perfused two-electrode voltage cl

283 these vesicles are a distributed system for divalent cation uptake and release, but in this case the

284 Manganese (Mn) and zinc (Zn) are essential divalent cations used by cells as protein cofactors; var

285 To enable dynamic sensing of divalent cations via PAI, we have engineered a new rever

286 ligohistidine-appended proteins for chelated divalent cations was exploited to facilitate this intera

287 ally, exposure to elevated concentrations of divalent cations was found to restore touch-evoked behav

288 Upon addition of EDTA and EGTA, the divalent cations were sequestered from the stabilized ap

289 ould have been prevalent in early oceans) or divalent cations (which would have been required for RNA

290 exhibit a significant structural response to divalent cations, which goes beyond generic electrostati

291 ced Gla residues allow binding of functional divalent cations, which induces end-to-end alpha-helices

292 ic residues and lipid-selective targeting by divalent cations, which is relevant to the general signa

293 owever, SLO1 is activated by Ca(2+)and other divalent cations, while SLO2 (Slack or SLO2.2 from rat)

294 organelles rich in polyphosphate chains and divalent cations whose significance in these parasites r

295 f this state is influenced by interaction of divalent cations with both activating and inhibitory cyt

296 lts depict that owing to the substitution of divalent cations with monovalent ones, asphaltene deposi

297 calcium can be easily displaced by mono- and divalent cations with no effect on activity, whereas rem

298 alent-permeable Fuji T1 is able to transport divalent cations without a major increase in resistance.

299 pproximately 16 muM), using an extracellular divalent cation, zinc (Zn(++)), as a nonspecific positiv

300 te the effects of two biologically important divalent cations, Zn(2+) and Ca(2+), on VIF network stru