ライフサイエンスコーパス: divergent

1 domain, are anatomically and physiologically divergent.

2 at these two functions might be structurally divergent.

3 y taxa, particularly those ~20 million years divergent.

4 enetic analyses reveal Homotherium as highly divergent (~22.5 Ma) from living cat species, with no de

5 ng on levels of PRS identifies significantly divergent 5-year risk trajectories after accounting for

6 ICEs), it is unclear how these factors exert divergent actions.

7 Two divergent adaptive landscapes are recovered for aquatic

8 mising bipolar filament formation but led to divergent adhesion phenotypes and NMIIA contractile acti

9 MCP, SEA and KUD were highly correlated but divergent among datasets.

10 average phage genome and are among the most divergent and difficult-to-identify genes using homology

11 The most divergent and numerous cluster of 2017-2018 strains was

12 Our previous studies identified two divergent and polymorphic KLRA alleles within the NK com

13 This divergent and step-economic approach provides a facile a

14 and C as well as their C2 epimers, featuring divergent and stereoselective syntheses of the N-acetyl-

15 The divergent and stereoselective synthesis of [3+1]-, [2+2]

16 th [2 + 2] cycloadditions, leads to concise, divergent, and redox-economic total syntheses of several

17 f these effector molecules is however highly divergent, and tools that identify and preselect CD8(+)

18 due to a spontaneous stereo and structurally divergent assembly of the building blocks.

19 Although divergent at the primary structure level, CAL1 thus bind

20 ion and characterization of distinct, highly divergent bacteriophage families.

21 tional studies indicate that the genetically divergent BCG strains have different effects.

22 gle gene has contributed to the evolution of divergent behavioral phenotypes in the white-throated sp

23 an intermolecular beta-sheet around a highly divergent beta-strand of the BTB domain.

24 aximum clot firmness (MCF) was significantly divergent between both patient groups and correlated wel

25 bacterial and archaeal communities are more divergent between locations and appear mainly driven by

26 sms controlling its transcription are likely divergent between them.

27 o 2.9 angstroms) bound to three ligands with divergent bias profiles: the balanced endogenous agonist

28 C (PKC) while enabling exploration of their divergent biological functions.

29 lly distinct cell populations specialized in divergent biological functions.

30 line-somatic variant interactions results in divergent biological pathway alterations between primary

31 revealed that RNase P and RMRP, two sequence-divergent but structurally related non-coding RNAs, shar

32 es from congeneric species ~20 million years divergent, but existing Vitis marker platforms have cros

33 ensable for DNA cleavage inhibition and have divergent C termini that are required in each case for i

34 ranscriptional activation activity, due to a divergent C-terminal domain, but retains the ability to

35 Divergent C. difficile germination models have been prop

36 y stages of retroviral infection, and reveal divergent capsid-based EB1 mimicry across retroviral spe

37 oreal forest land use practices can generate divergent carbon legacy effects.

38 ue cell-division cycles, and a repertoire of divergent CDKs and cyclins of poorly understood function

39 Importantly, we found divergent cell types associated with specific regulatory

40 generation and offer new insights toward the divergent cellular activities that distinguish regenerat

41 her any signal arises through directional or divergent changes in feedback outcomes with evolutionary

42 Remarkably, the highly divergent channel possesses similar features as human Ca

43 resistance to structurally- and functionally-divergent chemotherapeutic drugs.

44 TCF binding site expansions to conserved and divergent chromatin looping in human and mouse.

45 ed in the retinal output by a remarkable non-divergent circuit: cone -> midget bipolar interneuron ->

46 Pharmacological reactivation of suppressed divergent circuits synergizes strongly with inhibition o

47 ressing cells and inhibited Nef alleles from divergent clades of HIV and simian immunodeficiency viru

48 distinct clustering of viral sequences into divergent clades, indicating that these genes are virus-

49 tic analysis shows that FabIs fall into four divergent clades.

50 Divergent, climate-sensitive landscape histories do not

51 rders of 20 oak species (genus Quercus) from divergent climates of origin that were harvested after t

52 haviors in drosophilid species are shaped by divergent climates.

53 c immune dysfunction and its contribution to divergent clinical courses in CF.

54 not of SAR1A could restore secretion, and a divergent cluster adjacent to the SEC31/SEC23-binding si

55 Highly divergent co-existing strain variants emerge during colo

56 their parental compartment status at B6/Cast divergent compartments owing to cis effect.

57 Divergent conformational dynamics of CYP2J2 due to the b

58 inally, in a challenging circuit with highly divergent connections, BAcTrace correctly identified 12

59 s may arise because research is conducted in divergent contexts.

60 ptomic differences between these genetically divergent crosses.

61 that during Plasmodium male gametogony, this divergent cyclin/CDK pair fills the functional space of

62 es of a decision process that must reconcile divergent data, we developed an uncertainty scoring tool

63 two closely related sea urchins with highly divergent developmental gene expression and life histori

64 ional pathways may direct bHR/bLR rats along divergent developmental trajectories and promote a widel

65 nates is addressed with the development of a divergent, diastereoselective strategy for the monoproto

66 We evaluated the divergent dimerization behavior by measuring the strengt

67 We find divergent directions of changes in trait-pairs between s

68 ve found shared biological mechanisms across divergent disease etiologies.

69 early immune signatures that correlate with divergent disease trajectories.

70 tumor suppressor (VHL), are associated with divergent diseases.

71 one chimeric DPR (cDPR) species underlie the divergent DPR pathology between c9ALS/FTD and SCA36.

72 sms that allow IL-2-STAT5 signaling to exert divergent effects across CD4(+) T cell subsets and highl

73 Collectively, these findings identified divergent effects of DDRs on primary tumour growth and e

74 n of TWAS associations may be complicated by divergent effects of model SNPs on phenotype and gene ex

75 sized that variants would lead to functional divergent effects on BET proteins.

76 des of a radical polycyclization cascade for divergent elaboration and functionalization.

77 Here, we identify divergent epigenetic patterns involved in hemispheric as

78 ification of a conserved yet mechanistically divergent ESCRT-mediated lentivirus budding process in g

79 ogether, our results support the thesis of a divergent evolution in the control of vertebrate reprodu

80 e substrate-binding pocket that underlie the divergent evolution of substrate selectivity toward indo

81 ing of enzymes from these clusters suggested divergent evolution of the adenylate-forming superfamily

82 main chromatin binding proteins and point to divergent evolution of their regulation.

83 fennig introduce character displacement, the divergent evolution of traits in overlapping species.

84 th single-phase life cycles, which may drive divergent evolutionary dynamics.

85 of echinocandin gene clusters indicated the divergent evolutionary lineages of echinocandin gene clu

86 atal laminae, and that these bones underwent divergent evolutionary trajectories in placoderms and os

87 rtitioned their ancestral functions based on divergent expression across a diverse expression atlas.

88 This divergent expression and induction of cytokines appears

89 nregulated by biotic stress, the majority of divergent FAD2 genes in tomato are upregulated by one or

90 In addition, tomato has seven divergent FAD2 members that lack Delta12-desaturase acti

91 In mammals, the divergent family member Robo3 does not bind Slits, but i

92 cess these natural products in a concise and divergent fashion is highly desirable.

93 ydrolycopecurine (7) have been realized in a divergent fashion.

94 ceptor activation, and reveals conserved and divergent features in G(i) coupling.

95 razil's ZH program, variable outcomes across divergent food security dimensions, and synergies and tr

96 conformational switches between structurally divergent forms.

97 These haplotypes are highly divergent, frequently associated with structural variant

98 ect unknown phages, some of which are highly divergent from the known phage families.

99 methylators were dominated by hgcA sequences divergent from those in well-studied, confirmed methylat

100 loped distinct morphological characteristics divergent from urothelial carcinoma are extreme examples

101 le stochasticity-dominated processes lead to divergent functions (as in the flooded agroecosystem).

102 llar, and supraspinatus tendons due to their divergent functions and high rates of injury and tendino

103 e use MAGGIE to gain novel insights into the divergent functions of distinct NF-kappaB factors in pro

104 organizational principles that underlie its divergent functions.

105 mically related neurons with specialized and divergent functions.

106 for lung macrophages to switch between these divergent functions; therefore, understanding the mechan

107 MC4R is revealed as a structurally divergent G protein-coupled receptor (GPCR), with more s

108 Notably, cell types with divergent gene-expression profiles often shared very sim

109 The most divergent genes accelerated earlier, retained a high rat

110 oliferation of transposable elements and (5) divergent genetic innovations underlying the convergent

111 ish genomes reveal a mosaic of conserved and divergent genomic characters evolved from a shared ances

112 ate-recognition mechanism underpinning their divergent genomic methylation activities.

113 Divergent genomic rearrangements of the MHC II pathway a

114 Extant land plants consist of two deeply divergent groups, tracheophytes and bryophytes, which sh

115 that five Formica species exhibit homologous divergent haplotypes spanning 11 Mbp on chromosome 3.

116 asses of hospitalized patients with TBI with divergent healthcare needs, informing the planning of he

117 e and tartrate, perhaps by the activity of a divergent histidine kinase-response regulator gene pair.

118 ast and present factors varying based on the divergent histories of the world's biogeographic realms

119 Highly divergent HIV drug resistance profiles were observed amo

120 high-quality human assemblies of genetically divergent human populations to identify missing sequence

121 We aimed to identify divergent immune and microbial metagenome profiles of st

122 a, a phenomenon that could contribute to the divergent immune responsiveness to vaccines and suscepti

123 The divergent impact of estrogen on hepatobiliary fate was c

124 fferent signatures encode for mutations with divergent impact.

125 s on hyperinsulinemia and hyperglycemia were divergent in diversity outbred mice that model human gen

126 show that PTC2 haplotypes are exceptionally divergent in structure and sequence.

127 erein suggest that F. virguliforme modulates divergent infection profiles through transcriptional pla

128 hesized that an "efflorescence/deliquescence divergent infectivity" (EDDI) model accurately predicts

129 of an important human pathogen and highlight divergent integration strategies of retroviruses.

130 y, we identified heterogeneous and sometimes divergent interval changes in leukemic clones within a s

131 le seahorses (Hippocampus) featured a highly divergent invariant chain (CD74).

132 d TR1 sequences, recruit their own novel and divergent kinesin-14 family members to form neocentromer

133 we report new activator domains, including a divergent KRAB.

134 a full-factorial design with snakes from two divergent life-history ecotypes, which are known to diff

135 cer cells to control their proliferation and divergent lineage dependencies during tumor progression.

136 This is the first member of a third divergent lineage shown to infect penaeid decapods.

137 We identified 17 divergent lineages in the neustonic daphniids that were

138 ogenetic analyses revealed the presence of 8 divergent lineages occurring across the gradient with ge

139 nome, and evidence for hybridization between divergent lineages.

140 Moreover, we identify one highly divergent locus in African taurine cattle, which is puta

141 are characterized by overlapping rather than divergent male and female values.

142 ocess, starting from N(tolyl)(3) in a highly divergent manner (7 examples).

143 r reticulatum may provide both conserved and divergent mechanisms as a resource in breeding for droug

144 ar function in BL women, as well as possible divergent mechanisms between BL men and women based on e

145 idepressant-like effects through related but divergent mechanisms of action.

146 e studies provide insight into conserved and divergent mechanisms of lentivirus-host interactions inv

147 tas suggested that PFOA and GenX may exhibit divergent mechanisms of toxicity in the embryo-placenta

148 conserved, suggesting that the PCOs may use divergent mechanisms to oxidize their substrates.

149 ates this process, a component of which is a divergent member of the DYRK family of protein kinases,

150 omatin structure and gene expression in this divergent member of the Excavata.

151 nity to directly examine the contribution of divergent migratory behaviour to reproductive barriers.

152 The approach also predicted highly divergent MoAs for two FDA-approved antihistamines.

153 We identified divergent modes of initial axon growth that prefigure di

154 ing specificity, conformational variability, divergent modes of signaling, and evolution.

155 ved between mouse and human, emphasising the divergent molecular mechanisms of PGC specification.

156 ti-genic enhancers engaged in the control of divergent molecular pathways.

157 w that tumours driven by these variants have divergent molecular properties that manifest in selectiv

158 WM patients using DNA methylation and reveal divergent molecular signatures among WM patients.

159 However, in the early divergent moss Physcomitrella patens, 3D growth is prece

160 c cells, respectively, and thereby regulates divergent MTP expression.

161 gene-dense D. gyrociliatus genome presents a divergent Myc pathway, a key physiological regulator of

162 e core of the glideosome is an essential and divergent Myosin A motor (PfMyoA), a first order drug ta

163 anscription by these factors is dependent on divergent N-terminal domains.

164 cal H2A variants H2AZ and macroH2A1/2 at the divergent N-terminal tail lysine residue.

165 sense to each other and are transcribed from divergent noncoding RNAs in the latency-associated trans

166 To date, the reason for the divergent observations remains unknown.

167 ors for BCCs and SCCs that likely impact the divergent oncogenic pathways, paving the way for targete

168 from an initial hit molecule, we report its divergent optimization toward the ATPase family AAA doma

169 etabolically distinct bacteria indicative of divergent oral environments, with aciduric species enric

170 ation of a nucleolus gene module across very divergent organisms, and in the second, we show how the

171 though some studies have reported the widely divergent organization of claustrum projections, others

172 We found divergent overwintering strategies according to reproduc

173 of Encelia species hybridize at ecologically divergent parapatric boundaries, such mechanisms may mai

174 Conversely, deletion of divergent pathway components accelerates leukaemogenesis

175 with this central oncogenic driver activate divergent pathways and subvert transformation.

176 Hence, reactivation of divergent pathways can be leveraged as a previously unre

177 es and aromatic haloalkynes proceeds through divergent pathways depending on the nature of the cataly

178 Thus, two divergent pathways enable both rapid activation and pers

179 These findings indicate that divergent pathways from the avBST are responsible for th

180 lysis identified the inflection point in the divergent pathways, allowing future work to predict whic

181 Here, we find that these divergent patterns correlate with the pharyngeal arch ex

182 om The Cancer Genome Atlas (TCGA) and reveal divergent patterns for sex bias in immune features acros

183 variation within temporal windows can drive divergent patterns of pathogen dynamics within and acros

184 ic framework for the recognition of sequence-divergent peptide hormones in plants.

185 n cell type-specific contexts, which produce divergent phenotypic outcomes.

186 nd sensitive from closely related strains to divergent phyla.

187 We find strong evidence for a divergent phylogenetic signal in feedback outcomes.

188 ignal of ancient introgression and infer the divergent phylogenetic topology for the white oak clade.

189 within different surrounding tissues and via divergent physical mechanisms.

190 green peach aphid Myzus persicae to colonize divergent plant species.

191 Two phenotypically divergent Poncirus accessions are found to be clonally r

192 during the Archaic Age, derive from a deeply divergent population that is closest to Central and nort

193 migratory birds in North America have shown divergent population trends relative to resident species

194 oton pulses, inherently broadband and highly divergent, pose a challenge to established beamline conc

195 lopment of a photocatalytic strategy for the divergent preparation of functionalized bicyclo[1.1.1]pe

196 attention), can explain our observations and divergent previous findings.

197 have been further validated by RT-qPCR using divergent primers spanning back-splicing junctions.

198 volved to enable distinct reaction modes for divergent product formations.

199 ed to MYC translocations and associated with divergent progression-free survival patterns.

200 attain high isoform selectivity through the divergent projection of substituents into both the "sele

201 tions of dopamine-producing VTA neurons with divergent projections to the nucleus accumbens (NAc) cor

202 fly Drosophila melanogaster to characterize divergent properties of feature selection.

203 evolution is best explained by a process of divergent pulses of change.

204 Structurally Divergent Reactions on Racemic Mixtures are atypical pro

205 In conclusion, the divergent reactivity can be attributed to differences in

206 ur experimental results, we propose that the divergent receptor conformations stabilized by Na(+)-sen

207 This indicates that divergent recovery trajectories may be triggered concurr

208 nding site and make up the most structurally divergent regions in cognate Nod factor receptors.

209 activation appear to determine the observed divergent regioselectivity.

210 th factor receptor alpha (PDGFRalpha) in the divergent regulation of the two different adipose progen

211 een species, and suggest that, more broadly, divergent regulatory mechanisms may exist among ortholog

212 ipotency, but its role in the evolutionarily divergent regulatory network of human PGCs (hPGCs) remai

213 are so context dependent and even frequently divergent remains poorly understood.

214 Thus, distinct modes of NPC division have divergent requirements for Ino80-dependent HR DNA repair

215 This was demonstrated by a divergent response of LAI to warming asymmetry.

216 netic approach, we dissect the basis of this divergent response to extracellular cues by profiling ge

217 In summary, we found that the divergent response to simulated N deposition depended on

218 Divergent responses could reduce synchrony both within s

219 inhibitors as they identify both common and divergent responses in cells harbouring the same genetic

220 Succinate signaling via SUCNR1 guides divergent responses in immune cells, which are tissue an

221 Phi(app,RI) also exhibited divergent responses to controlled pH adjustment and alum

222 Distantly related plant species show more divergent responses to each other's soil microbiota comp

223 Divergent responses to the K-channel antagonist, kappaM-

224 eet the criteria for the disorder as well as divergent responses to treatments.

225 oblasts underwent rapid (within minutes) and divergent responses, characterized by nuclear area expan

226 propose a conceptual framework to interpret divergent responses.

227 flexible in architecture as both shared, and divergent, responses to inhibition of FGFR2 kinase activ

228 identify host factors have produced largely divergent results, with few overlapping hits across diff

229 gly appreciated, may partially explain these divergent results.

230 V provirus and its functionality and produce divergent results.

231 the TRIM5alpha v1 loop affect restriction of divergent retroviruses.

232 n the context of a classical visual SL task, divergent rhythmic EEG activity in the interstimulus del

233 ing due to transcriptional interference from divergent ribosomal promoters.

234 r grip mutations (K375R and R376K) exhibited divergent RNA recombination, ribavirin sensitivity, and

235 navirus-2 (SARS-CoV-2), a novel evolutionary divergent RNA virus, is responsible for the present deva

236 riven remodeling that allows them to bind to divergent RNAs.

237 We then highlight the emerging and divergent roles for individual GRASP proteins, focusing

238 , is of particular interest because it plays divergent roles in different tissues by partnering with

239 rall, these data reveal that Rab27a can play divergent roles in regulating pro-metastatic propensity

240 eported, no studies investigated whether the divergent roles of CBX7 could be due to distinct functio

241 ens and provide mechanistic insight into the divergent roles of MAGEA6 during pancreatic cancer initi

242 of a readily accessible helicene provided a divergent route to four electron-deficient analogues con

243 Trends in survival revealed divergent seasonal patterns, which were similar across a

244 from foetal muscle enhancers, perhaps due to divergent selection for higher muscle mass in archaic ho

245 We identified a clear signature of divergent selection in a region of chromosome 8 introgre

246 two modes of opposite parity, which exhibit divergent selection rules that depend on inversion symme

247 utational studies suggest that the origin of divergent selectivity between PMe(3) and other phosphine

248 y studies of reaction kinetics, we show that divergent sequence selectivity for AB- and ABB-type copo

249 Herein, an electronically divergent series of ferric heme superoxo oxidants mediat

250 eLCs, or, alternatively, hPSCs cultured with divergent signaling inhibitors, are induced into hPGC-li

251 Overall, our results demonstrate that the divergent signaling output from multifunctional receptor

252 A phylogenies suggested that it was a highly divergent sister lineage to all extant cat species [6-8]

253 Highly divergent sites in multiple sequence alignments (MSAs),

254 udinal gradient in eastern China with highly divergent species pools.

255 Herein, we report the divergent, stereospecific reaction of fluoroiodomethylli

256 t cells from a cross between two genetically divergent strains, we mapped 86 trans-acting loci affect

257 we find that in mice, sex is associated with divergent strategies for sampling and learning about the

258 , and the small GTPase Ras1, as well as with divergent stress response regulators, including the cell

259 Additionally, the discovery of divergent stress-induced mortality based on parental ori

260 ucosyltransferases to identify conserved and divergent structural features for donor and acceptor rec

261 ion reactivity enhancement and highlight the divergent structural requirements inherent to supporting

262 two classes of paralogs: a more functionally divergent subset and another that retained more function

263 The divergent substrate preference between DNMT3A and DNMT3B

264 ed an array of paralogous enzymes exhibiting divergent substrate preferences and catalytic mechanisms

265 utionarily conserved insertion mechanism for divergent substrates utilizing a hydrophilic groove.

266 Genetic reactivation of the divergent (suppressed) pathway comes at the expense of t

267 -Like Receptors 7 and 8 (TLR7/8), leading to divergent suppression of TLR7 and activation of TLR8, in

268 t thalamocortical nuclei through dynamically divergent synapses.

269 bond analysis combined with the strategy of divergent synthesis to access six different natural prod

270 In the divergent synthesis, p-Cl substituents in tris(4-chloro-

271 Here we show how a complementary divergent synthetic approach that is holistically patter

272 A divergent synthetic strategy provides access to both nat

273 s have also been explored to demonstrate the divergent synthetic utility of the unsaturated spirocycl

274 Underlying these divergent T cell responses in pancreas and lung cancer a

275 eins that make up the kinetochore are highly divergent; the inner kinetochore comprises at least 20 d

276 Given that muscle BDNF had divergent therapeutic effects that depended on muscle ty

277 Here, we show divergent thermal response patterns for marine AO across

278 s underwent fMRI and performed a simulation, divergent thinking, and nonepisodic control task.

279 pecifically modulate episodic simulation and divergent thinking, and suggest that the hippocampus is

280 lay a causal role in episodic simulation and divergent thinking.

281 usly associated with memory, simulation, and divergent thinking.

282 The work extends the divergent total synthesis of four to now six different n

283 ntributions of migratory behaviour vs. other divergent traits to reproductive isolation.

284 nhancers are characterized by bidirectional, divergent transcription have challenged the traditional

285 It remains unknown whether divergent transcriptional networks underlie these cortic

286 se wherein LBS and proteotoxic stress deploy divergent transcriptional UPR programs.

287 tin dynamics during stretch revealed similar divergent trends, with F-actin shifting away from (5% st

288 Divergent trigeminal nerve (CN V) differentiation and al

289 rm square-planar 4:1 complexes with multiple divergent trityl groups poised to engage in embraces.

290 tructurally characterized two evolutionarily divergent uridine phosphorylases, PcUP1 and PcUP2 from t

291 Nursing homes have highly divergent urine culturing rates; this variability is ass

292 The most likely explanation for the markedly divergent VE estimate from cases identified by single-ti

293 ewhere; significantly, they demonstrate that divergent versions of Jeremiah circulated in parallel th

294 pathway allows bulbar interneurons to assay divergent versions of the same sensory input pattern.

295 five genes that are strongly associated with divergent visual preferences.

296 2 Tc17 cell subsets that were metabolically divergent, were developmentally related, and expressed C

297 ariation rates as type 1 appeared to be more divergent, while type 2 demonstrated novel substructures

298 have been recorded using highly coherent and divergent x-ray waveguide radiation.

299 ver and engineer, in particular for the more divergent XNA chemistries.

300 lexity crosses (RCCs) between phenotypically divergent, yet genetically similar, rodent substrains.