ライフサイエンスコーパス: diversely

1 As efficient asymmetric syntheses of diversely 3,3-disubstituted oxindoles are currently deve

2 In response to diversely acting drugs, myobundles undergo dose-dependen

3 xpression as a function of transformation by diversely acting oncogenes, DNA damage, and cancer cell

4 hich amplified a pre-existing Treg identity, diversely activating or repressing distinct programs, de

5 and glia of the normal vertebrate brain are diversely aneuploid, forming mosaics of intermixed aneup

6 rs, and various strategies adopted to obtain diversely arylated products.

7 Knorr pyrrole synthesis in which simple and diversely available starting materials, such as 1,2-amin

8 Mercury is a diversely bioaccumulating heavy metal pollutant toxic to

9 predicts accurate geometries and energies of diversely bonded molecules and materials (including cova

10 highly O-glycosylated mucin domains that are diversely decorated by Golgi glycosyltransferases to bec

11 roups and set the stage for the synthesis of diversely decorated chalcogenides.

12 his developed protocol is that the resulting diversely decorated heterocycles contain a quaternary ca

13 Here we show that diversely different chemistries of dynamic bonds map int

14 localize tTF to occlude tumor vessels in two diversely different murine tumor models.

15 that another set of nodes, which have edges diversely distributed across the network, form a "divers

16 variety of calcium-dependent events, and are diversely distributed throughout the developing CNS.

17 Microsporidia are diversely distributed, opportunistic, and density-depend

18 In some of the Alchemy samples, and diversely from the models, a peculiar distribution of Zn

19 Each method can be used to make diversely functionalised cyclic sulfonamides in good to

20 ochemical and mechanochemical strategies for diversely functionalized 3-nitro-2-aryl-immidazo[1,2-a]p

21 Twenty-seven diversely functionalized [1H,3'H]-3-substituted 2,2'-dii

22 ole, and tetrazole) and porphyrins to access diversely functionalized A(3)B, A(2)BC, and A(2)B(2) por

23 haloheteroarenes, are compatible, generating diversely functionalized BCBs and hetero-BCBs present in

24 We report herein an efficient synthesis of diversely functionalized BCBs by a Pd(II)-catalyzed form

25 These diversely functionalized benzenes (1,2-teraryls or 1,3-t

26 en discovered to directly access densely and diversely functionalized benzofurans and benzothiophenes

27 pair strategy that uniquely allows access to diversely functionalized benzoxazepine and indolopyrazin

28 o-step strategy has been developed to access diversely functionalized benzylic sulfonamides.

29 ker oxidation and olefin metathesis provides diversely functionalized building blocks and expands the

30 n reactions, allowing for the elaboration to diversely functionalized building blocks.

31 actions of a carbohydrate-derived nitrone on diversely functionalized calix[4]arenes.

32 3-substituted 5,5-dimethyl isoxazolines from diversely functionalized chlorooximes and di-tert-butyl

33 e vinylation step and the ready synthesis of diversely functionalized compounds, thereby underscoring

34 Diversely functionalized diaza[5]helicenes have been syn

35 ate synthesis, it allows for rapid access to diversely functionalized diazocines on gram scales.

36 n efficient methodology for the synthesis of diversely functionalized dihydrodibenzo[b,e]azepin-11-on

37 onomical approach toward the construction of diversely functionalized dihydroquinolinones bearing qua

38 ide synthesis that enable the preparation of diversely functionalized examples and provide the basis

39 el and efficient method for the synthesis of diversely functionalized furans is developed via DBU-med

40 pled with opportunities for the synthesis of diversely functionalized heterocyles from a single templ

41 w polymeric capsules that can be readily and diversely functionalized in the core.

42 ansition-metal-free approach to synthesizing diversely functionalized isothiocyanates from the corres

43 tion of 1,4-disubstituted 1,2,3-triazoles as diversely functionalized molecules.

44 erfect regioselectivity to a wide variety of diversely functionalized naphthalenes in 41-78% yield.

45 ide polymerization toward the evolution of a diversely functionalized nucleic acid aptamer for human

46 tide polymerization toward the generation of diversely functionalized nucleic acid polymers is descri

47 reactive intermediates for the synthesis of diversely functionalized ortho-disubstituted arenes and

48 ld have considerable use in the synthesis of diversely functionalized pharmacophores.

49 etathesis that allows access to a variety of diversely functionalized phosphono-oxaheterocycles.

50 an be used for the downstream preparation of diversely functionalized piperidines.

51 ons for the Suzuki-Miyaura cross-coupling of diversely functionalized primary alkyltrifluoroborates w

52 ey allow the synthesis of large libraries of diversely functionalized products in a short time when r

53 s report, metal- and azide-free synthesis of diversely functionalized pyridyl-1,2,3-triazole derivati

54 advantageous in organic synthesis that yield diversely functionalized scaffolds from common starting

55 e is demonstrated by the chlorination of >30 diversely functionalized substrates and the late-stage c

56 This enabled the generation of diversely functionalized synthetic nucleic acid polymer

57 Diversely functionalized tetrazoles are tolerable also.

58 ermore, the bridged bicyclic products can be diversely functionalized through simple transformations.

59 n efficient one-pot synthesis of a series of diversely functionalized trisubstituted 4(5)het(aroyl)-2

60 ically increase blood glucose from among the diversely functioning cell types in the ventromedial hyp

61 vergent annulations were observed leading to diversely fused N1-C2 or C2-N3 indolopyrido-quinazolinon

62 -Michael-aldol strategy for the synthesis of diversely fused pyrrolo[1,2-a]quinoline (tricyclic to pe

63 rate high-quality data from processing these diversely generated WES samples.

64 Unexpectedly, one TCR responded to diversely glycosylated and unglycosylated forms of mycok

65 on driven by lateral network connectivity is diversely implemented throughout a cortical column.

66 Despite being found diversely in male gametes (e.g., Plasmodium falciparum m

67 old for apoptosis that is set and controlled diversely in various cancer types.

68 uenza virus influenced subsequent infections diversely, inhibiting vaccinia virus but enhancing LCMV

69 itional alpha,beta-unsaturated ketone system diversely installed in the A-ring based on this class of

70 The hippocampus is diversely interconnected with other brain systems along

71 31-Tyr132 or, alternatively, is comprised of diversely located residues which come into proximity onl

72 Mutations within laminin-5 genes were diversely located, with the most severe forms of JEB cor

73 Clusters were of diversely mixed subclass composition and showed distinct

74 A single substitution from our diversely modified nucleotide library leads to a 37-fold

75 osttranslational modifications (PTMs), which diversely modulate biological functions, represents a si

76 hatic alcohols is described for synthesizing diversely multifunctionalized benzocoumarins.

77 PI-2 by binding to degenerate DNA targets at diversely organized promoters.

78 Because SsrB-dependent promoters are diversely organized, additional mechanisms of transcript

79 ncephalon involves the coordinated growth of diversely patterned brain structures.

80 ation between human and mouse; however, many diversely patterned genes displayed marked shifts in reg

81 We report herein an efficient synthesis of diversely polysubstituted imidazo[1,2-a]pyridines, a fam

82 onent, its capacity to draw on plentiful and diversely populated amine and carbonyl feedstocks is sho

83 s assembly of chiral PHOX ligands as well as diversely protected amino alcohols.

84 t' strategy may underline activation of many diversely regulated enhancers.

85 Tup1 that inhibits the transcription of many diversely regulated genes.

86 f differential enzymatic activity within the diversely regulated ppGaNTase family, which may play a r

87 The mu opioid receptor (MOR) is a diversely regulated target for the alleviation of pain i

88 c-function link with its cognate ligands and diversely reported inhibitors.

89 In diversely resourced care settings, obstacles to providin

90 We have constructed three types of ToLs for diversely sampled organisms using the sequences of whole

91 Diversely selected acrylamides including 2-cyano-N-aryla

92 e genes are likely to be either uniformly or diversely selected among regions, providing a footprint

93 Through the coassembly of mGBCPs with diversely sized inorganic fillers such as metal ions (ca

94 on of plasmonic fluorescence enhancement for diversely-sized molecular assemblies.

95 the specification and spatial positioning of diversely specialized cell types.

96 esity epidemic is the subject of an immense, diversely specialized research effort.

97 T and plasmid analysis shows that MCRPEC are diversely spread throughout China and pervasive in Chine

98 aracterization of transcriptional changes in diversely stimulated and pathologically relevant cells t

99 This method affords diversely substituted 1,1,2-triarylethyl products that o

100 ent redox-neutral and atom-economic route to diversely substituted 1,3-diamino-B-carbolines.

101 and an amine, resulting in the formation of diversely substituted 1,4-diamino-2-butynes,is described

102 odology is compatible with a wide variety of diversely substituted 1,4-naphthoquinones as well as var

103 and efficient protocol for the synthesis of diversely substituted 2,2'-bibenzimidazoles from the rea

104 d cyanamides comprises an efficient route to diversely substituted 2,6-diaminopyridines (28 examples;

105 A series of diversely substituted 2-aryl acetophenones have been obt

106 The synthesis of diversely substituted 3-alkyl/aralkyl/arylamino-1,4,2-be

107 A method for the synthesis of diversely substituted 3-fluoropyridines from two ketone

108 A rapid and general access to diversely substituted 5-alkoxyoxazoles 2 (i.e., R(1), R(

109 These methods allowed us to prepare 36 diversely substituted 5-azaindoles in good yields.

110 fficient method for sulfenylation to achieve diversely substituted 5-sulfenyl-2-iminothiazoline deriv

111 ectron-poor azide substrates, and a range of diversely substituted [1,2,3]triazolo[1,5-a]pyrazine pro

112 lished through the synthesis of more than 60 diversely substituted [4]dendralene molecules, along wit

113 upported DMAP catalyzed one-pot synthesis of diversely substituted alpha-pyrones.

114 amines with imidoylbenzotriazoles 6a-w gave diversely substituted amidines 7a-Aa in 76-94% yields.

115 htforward alternative protocol for accessing diversely substituted and biologically promising alkyl 2

116 The protocol leads to quick access to a diversely substituted and functionalized piperidone fram

117 Diversely substituted anilines are prepared by treatment

118 insertion allowing straightforward access to diversely substituted APOs.

119 ectivity of arene C-H amination reactions on diversely substituted arenes.

120 loyloxy)benzamides with 1,5-enynes to access diversely substituted aromathecin derivatives involving

121 A broad range of diversely substituted aryl amines and pyrazolines are su

122 r approaches generate single regioisomers of diversely substituted chlorins, and in every case, the 2

123 nt procedure for the synthesis of highly and diversely substituted chromanes and 2 H-chromenes.

124 The ready access to these diversely substituted compounds is expected to facilitat

125 rocess allows for the efficient formation of diversely substituted cyclopentanes as well as the const

126 rt a novel method to access a broad range of diversely substituted derivatives.

127 Specifically, diversely substituted di/triarylmethanes are generated w

128 library of compounds was created conjugating diversely substituted furazan rings with MC70, a well-kn

129 d 15 atom cyclic enkephalins incorporating a diversely substituted guanidine bridge have been prepare

130 Diels-Alder reaction to furnish a series of diversely substituted heterobiaryls, which is further di

131 reported, representing a general strategy to diversely substituted higher homologues of the dendralen

132 ion strategy has been developed to construct diversely substituted imidazo[1,2-a]pyridines and benzim

133 Diversely substituted indolines were functionalized at C

134 catalyzed regioselective tandem synthesis of diversely substituted indolo[2,1-a]isoquinolines 11a-r,

135 In this work, a series of diversely substituted isothiocyanates (R-NCS) were exami

136 We report herein an efficient synthesis of diversely substituted N-aryl-2-cyanoazetidines based on

137 of Cu-catalyzed three-component coupling of diversely substituted N-benzyl o-bromoaryl imines with m

138 combinatorial approach was used to generate diversely substituted novel sulfonanilides by parallel s

139 lems in accessibility and air-sensitivity of diversely substituted o-aminophenols from which they are

140 the effective Friedel-Crafts alkylation with diversely substituted o-iodobenzyl alcohol derivatives,

141 cted to Suzuki couplings for the creation of diversely substituted olefinic amino acid systems.

142 ollowed by decyanation of nitriles to access diversely substituted olefins is reported.

143 uated as a new approach for the synthesis of diversely substituted polycyclic derivatives of triazolo

144 o-step sequence provides efficient access to diversely substituted polycyclic dibenzofuran derivative

145 agents that reacted at room temperature with diversely substituted primary and secondary amines to pr

146 concept was devised and afforded a series of diversely substituted prodrugs by O-conjugation of the h

147 andem catalytic, five component synthesis of diversely substituted products.

148 nt oxidative annulation of alkynes furnished diversely substituted pyran[2,3,4- de]chromene-2-one der

149 ocyclization under ambient condition to give diversely substituted pyrroles 6a-m in moderate to good

150 vent-mediated pathway to afford a library of diversely substituted quinoxalines in moderate to good y

151 A number of diversely substituted silanes possessing both aryl and a

152 The original synthesis does not allow diversely substituted spirosilane derivatives to be synt

153 nt alpha-functionalized nitroalkenes affords diversely substituted sulfonylfurans and dihydrofurans.

154 gents to give secondary sulfonamides bearing diversely substituted tertiary amines in the beta- or ga

155 reoselective, the sequence can be applied to diversely substituted unsaturated Weinreb amides and val

156 Diversely substituted, partially saturated benzo[f]isoin

157 PDLC microtissues and monolayers react diversely to collagen membranes and bone substitute.

158 ng that the two human EF-G(mt)s have evolved diversely to negate the effect of a bacterial antibiotic

159 possibilities for different cells to respond diversely to similar stimuli.

160 elective Suzuki-Miyaura couplings to produce diversely tri- or tetra-substituted arylcyclopropanes in

161 enhance information coding in populations of diversely tuned neurons.

162 he induction of Th1-related chemokine CXCL10 diversely, which could favour the recruitment of distinc

163 ent-bond-forming activity (that is, reacting diversely with small molecules at one extreme or selecti

164 velopmental signal transduction pathways act diversely, with context-dependent roles across systems a