ライフサイエンスコーパス: division site

1 a moving zone of signalling activity at the division site.

2 hering complex on the plasma membrane at the division site.

3 required for AmiB's localization to the cell division site.

4 nge factor Gef3p interacts with Rho3p at the division site.

5 t all three proteins localize sharply to the division site.

6 d on actin filaments for localization to the division site.

7 he recruitment of the late components to the division site.

8 rentially at the pole distal to the previous division site.

9 artmentalize the cytoplasmic membrane at the division site.

10 er to position the nuclei away from the cell division site.

11 actomyosin ring is assembled de novo at the division site.

12 phosphatase, GFP-PhpP, both localize to the division site.

13 onstriction and remains highly mobile at the division site.

14 t of cell division and the previously formed division site.

15 cs of the assembled FtsZ ring at the midcell division site.

16 ophase band (PPB), which predicts the future division site.

17 s a regulator of cell-wall hydrolysis at the division site.

18 s toward MT plus ends located at or near the division site.

19 athway to inhibit FtsZ ring formation at the division site.

20 additional molecular motors to constrict the division site.

21 n and extracellular matrix remodeling at the division site.

22 livery of membrane lipids and cargoes to the division site.

23 f cell wall turnover at the Escherichia coli division site.

24 d synthesis of new peptidoglycan (PG) at the division site.

25 es two mechanisms to concentrate Rho1 at the division site.

26 n to promoting PPB formation at the cortical division site.

27 re found to be specifically recruited to the division site.

28 essential for their later appearance at the division site.

29 ted so that it concentrates precisely at the division site.

30 adjacent to but not within the previous cell division site.

31 DV2 to localize PDV2 (and hence ARC5) to the division site.

32 ity, new buds do in fact form within the old division site.

33 ke protein FtsZ, which forms a Z-ring at the division site.

34 nt role in the choice and positioning of the division site.

35 in actin filament assembly/stability at the division site.

36 on plane with their plus ends located at the division site.

37 00 nm) filaments spaced erratically near the division site.

38 rane but did abolish its localization to the division site.

39 new cell wall and is guided to the forecast division site.

40 t least 10 essential proteins at the nascent division site.

41 ssfully contacting the "programmed" cortical division site.

42 vely known as the divisome, at the incipient division site.

43 emodeling the peptidoglycan cell wall at the division site.

44 hibits Z-ring assembly everywhere except the division site.

45 onsible for selection and recognition of the division site.

46 d by a multiprotein complex assembled at the division site.

47 e E. coli both FtsE and FtsX localize to the division site.

48 otein localizes to a ring at the chloroplast division site.

49 izes into a ring that establishes the future division site.

50 oad band of cortex around the equator as the division site.

51 When CR constriction begins, Mid1 leaves the division site.

52 es on cellular geometry cues to position the division site.

53 acterial cells must remodel cell wall at the division site.

54 al peptidoglycan-synthesizing enzymes to the division site.

55 ire the Z-ring for recruitment to the future division site.

56 in placing the new cell wall at the correct division site.

57 novel action of MAP65-4 at the cortical cell division site.

58 as well as efficient removal of Chs4 at the division site.

59 h determines the ability of MapZ to mark the division site.

60 tion rely on the accumulation of FtsN at the division site.

61 ates cell polarity and localizes to the cell division site.

62 patiotemporal formation of the Z ring at the division site.

63 er alignment of the mitotic spindle and cell division site.

64 3 are interdependent for localization to the division site.

65 iding phragmoplast expansion to the cortical division site.

66 hile the LtaS enzyme accumulated at the cell division site.

67 therefore behaving as a permanent beacon of division sites.

68 localization of Cdv proteins but not FtsZ to division sites.

69 le in defining the position of mitochondrial division sites.

70 del may explain why DivIVA localises at cell division sites.

71 nts together minimizes formation of multiple division sites.

72 y polar, localizes at or near potential cell division sites.

73 a highly ordered hourglass structure at the division site [13] is largely unexplored.

74 s, in which filaments circle around the cell division site(2,3).

75 Given that capping protein arrives at the division site 20 min later than Cdc12p, capping protein

76 s the expected burst of PG hydrolysis at the division site, accompanied by amidase recruitment.

77 served mitotic exit kinase, localizes to the division site after Chs2 and directly phosphorylates Chs

78 p, which recruits IQGAP-related Rng2p to the division site, after which other node components accumul

79 eprophase band and persisted at the cortical division site afterwards.

80 We found that FtsN localizes to potential division sites, albeit poorly, in RG60 grown in LB with

81 s, aggregates of ring proteins remain at the division site and at additional foci in other parts of t

82 suggest that de novo F-actin assembly at the division site and directed transport of F-actin cables a

83 oth de novo-assembled actin filaments at the division site and existing filaments recruited by direct

84 rtex, where the localized Mid1 specifies the division site and induces contractile-ring assembly.

85 th because the mutant can recognize the cell division site and influences the localization of MinD.

86 and several other proteins that forms at the division site and is important for cytokinesis.

87 that DivIB only transiently localises to the division site and may mark previous sites of septation.

88 tubule-binding protein that localizes to the division site and mitotic microtubules and plays a criti

89 sion requires accurate identification of the division site and placement of the division machinery.

90 However, how myosin II is targeted to the division site and promotes AMR assembly, and how the AMR

91 r the last decade reside continuously at the division site and provide a lasting spatial reference fo

92 ructure that establishes the location of the division site and serves as a framework for assembly of

93 es into a ring-like structure at the nascent division site and serves as a scaffold for the assembly

94 rich membrane domains are formed at the cell division site and sites of polarized cell growth at cell

95 localization of FtsZ, PDV1, and ARC5 at the division site and that PDV1 and PDV2 together mediate th

96 both the positioning of the vegetative cell division site and the polar attachment of the chromosome

97 ZapA and ZauP co-localized at the division site and were each required for efficient divis

98 ation of Rga1 from the immediately preceding division site and, consequently, abnormal bud-site selec

99 DivIVA is specifically targeted to cell division sites and cell poles.

100 al through vesiculation and blebbing at cell-division sites and compensatory shrinkage of the inner m

101 rocess ensures the inactivation of old polar division sites and leaves the cell centre free for the a

102 ed on insertion of new wall material at cell division sites and that this localized growth is depende

103 ins, reduces peptidoglycan remodeling at the division site, and blocks compartmentalization of the cy

104 and in the placement of the chromosome, the division site, and individual structural and regulatory

105 cytokinesis regulators-Iqg1 and Inn1-at the division site, and results in an abnormal septum.

106 , distribution of type V myosin Myo52 to the division site, and timely recruitment of septum protein

107 mainly promoting the recruitment of PBP1 to division sites, and GpsB facilitating its removal from t

108 hat polymerizes into rings localized to cell-division sites, and the constriction of these rings driv

109 to the mother-bud neck and to the subsequent division site are dependent on its GDP-GTP exchange fact

110 el and the initial level of Cdc42-GTP at the division site are perturbed by noise added in the model.

111 As expected, active Rho1 levels at the division site are reduced in art1 and rgf3 mutant cells.

112 between the inner and outer membranes at the division site, as has been previously proposed.

113 ect proteins made in the same cell to active division sites, as when SpoIIQ is made in the mother cel

114 zes to the bud tip until the M phase, to the division site at cytokinesis, and then to the distal pol

115 uniformly along its length, the future cell division site at mid-cell is newly made and has no known

116 lusion (NO), which cooperate to position the division site at midcell.

117 cytokinesis, and prolonged exocytosis at the division site at the end of cytokinesis.

118 , which nucleates microtubules from the cell division site at the end of mitosis, and interphase MTOC

119 gly, both Chs2 and Chs3 are delivered to the division site at the onset of cytokinesis [6, 20].

120 nd directs the cell plate to the preselected division site at the plasma membrane to fuse with the pa

121 h as Escherichia coli, often mark their cell division sites at their cell midpoint so that daughter c

122 lacking DipM also showed OM blebbing at the division site, at cell poles and along the cell body.

123 ell division, where the nucleus moves to the division site based on cellular polarity cues.

124 yosin-II in budding yeast, was mobile at the division site before anaphase and became immobilized sho

125 racterize a novel factor that locates at the division site before FtsZ and guides septum positioning

126 It is recruited to active division sites before septal biogenesis, rotates around

127 l origin regions localize to the future cell division sites, before FtsZ.

128 PBP2 localized to the division site but its recruitment to the forming divisio

129 of aerial hyphae with partially constricted division sites but no clear separation of prespore compa

130 SftA colocalizes with FtsZ at nascent division sites but not with SpoIIIE at sites of chromoso

131 I complex have distinct localizations at the division site, but both are important for membrane expan

132 aromyces pombe, four septins localize to the division site, but deletion of the four genes produces o

133 RanGAP1 persistence at the cortical division site, but not its initial accumulation at the P

134 ER-mitochondria contacts mark mitochondrial division sites, but the molecular basis and functions of

135 , like its paralog AmiC, is recruited to the division site by an N-terminal targeting domain.

136 speculate that SPOR domains localize to the division site by binding preferentially to septal peptid

137 d are thought to target proteins to the cell division site by binding to "denuded" glycan strands tha

138 ations suggest that PBP2 is recruited to the division site by binding to its substrate, which is loca

139 ivating protein, prevents budding within the division site by inhibiting Cdc42 repolarization.

140 We conclude that Nod1 specifies the division site by localising Gef2 to the mitotic cell mid

141 lizes to the immediately preceding and older division sites by interacting with Nba1 and Nis1.

142 an-binding outer-membrane lipoprotein Pal at division sites by the Tol system.

143 act translocates to previously utilized cell division sites called cytokinetic remnants (CRMs).

144 ne trafficking to and membrane fusion at the division site cause the physical separation of the daugh

145 proteins assemble into a ring at the plastid division site, chloroplasts in the arc6 mutant contain n

146 ated with DamX: targeting the protein to the division site, conferring full resistance to the bile sa

147 ana arc5 mutants, chloroplasts arrest during division site constriction.

148 n pathogen lacking the canonical systems for division site control (nucleoid occlusion and the Min-sy

149 eprophase band function and the setup of the division site, cytokinesis and its spatial control remai

150 deposits the new cell wall, to the cortical division site delineated by the PPB.

151 For3 localization at the division site depended on the F-BAR protein Cdc15, and f

152 ations have validated some early concepts of division site determination.

153 log of the ATPase MinD, which serves in cell-division site determination.

154 , suggesting that minE and cdv3 both mediate division-site determination in cyanobacteria.

155 ion was blocked by altered expression of the division site-determining factor AtMinD.

156 hough localization of Rax1p and Rax2p to the division site did not appear to depend on Bud9p, normal

157 ombe, an equatorial MTOC (eMTOC) at the cell division site disassembles after cytokinesis, and multip

158 ates induced to insert outside the predicted division site do not elicit an AIR9 torus, suggesting th

159 e structure (Z-ring) assembled at the future division site during cell division.

160 t the cell tips during interphase and at the division site during cell division.

161 ing vesicle fusion and cargo delivery at the division site during cytokinesis.

162 guides the phragmoplast towards the cortical division site during cytokinesis.

163 on of the stable crescentin structure at the division site during cytokinesis.

164 PPB and remains associated with the cortical division site during mitosis and cytokinesis, requiring

165 ile actomyosin ring (CAR) and remains at the division site during septation.

166 riments suggest that CtpA accumulates at the division site during the last quarter of the cell cycle.

167 FtsK localizes at nascent division sites during every cell cycle and stimulates ch

168 lization at spindle pole bodies and the cell division site, E3 ligase activity, and mitotic checkpoin

169 FtsA recruits a small amount of FtsN to the division site earlier than previously recognized.

170 yet the mechanisms for recruiting Rho to the division site for cytokinesis remain poorly understood.

171 d negative signals cooperate to position the division site for cytokinesis.

172 substrate for SIN-mediated remodeling of the division site for efficient cytokinesis and provide evid

173 we observed (i) initial establishment of the division site, (ii) recruitment of early FtsZ-binding pr

174 data show that Gps1 is targeted to the cell division site in a biphasic manner, via Gin4 and Nba1, t

175 hich other node components accumulate at the division site in a characteristic sequence [3-6].

176 iae, the F-BAR protein Hof1 localizes to the division site in a complex pattern during the cell cycle

177 is an effector, UgtP, which localizes to the division site in a nutrient-dependent manner and inhibit

178 f the septin proteins, which localize to the division site in all animal and fungal cells but are ess

179 DipM localized to the division site in an FtsZ-dependent manner via its PG-bin

180 that ring proteins need not assemble at the division site in an invariant order.

181 tubules of the mitotic apparatus specify the division site in animal cells, we show here that the nuc

182 actin cables and causes misplacement of the division site in certain genetic backgrounds.

183 kbone synthesis proceeds in S. aureus at the division site in co-ordination with cell division, while

184 icating that FtsL and YgbQ colocalize to the division site in E. coli.

185 tem responsible for correct placement of the division site in Escherichia coli cells.

186 hat plays a crucial role in selection of the division site in eubacteria, chloroplasts, and probably

187 d phosphorylation precociously appear at the division site in filament-like structures and display in

188 s, such as rings or hourglasses, at the cell division site in fungal and animal cells [1-4] to carry

189 conformation, inhibits Cdc15 assembly at the division site in interphase, and precludes interaction o

190 demonstrate that FtsZ, which marks the cell division site in many bacteria, can be targeted to the m

191 system regulates the positioning of the cell division site in many bacteria.

192 tubule-binding proteins that localize to the division site in plants.

193 ture establishes the location of the nascent division site in prokaryotes.

194 spatial distribution by accumulating at the division site in response to external osmotic upshifts.

195 Proper placement of the cell division site in some rod-shaped bacteria requires two d

196 However, FtsQ is found at the cell division site in the absence of FtsL and FtsB.

197 A replication with establishment of a medial division site in the Gram-positive bacterium, Bacillus s

198 DV1 localized to a discontinuous ring at the division site in wild-type plants.

199 it follows that FtsN initially localizes to division sites in a SPOR-independent manner.

200 m septal peptidoglycan (SP) rings, appear at division sites in isolated sacculi.

201 n minimal medium or sucrose-free R2YE, where division sites in many aerial hyphae had finished constr

202 to localize to division sites, localized to division sites in the absence of FtsK, indicating that F

203 forms membrane domains at the cell pole and division sites in wild-type cells, the mutant cells stil

204 esize new wall material specifically at cell division sites, in the form of a flat circular plate tha

205 , IcsA localizes to poles and potential cell division sites independent of the cell division protein

206 llows us to target a protein directly to the division site independently of other cell division prote

207 o report that AmiB and EnvC are recruited to division sites independently of one another.

208 EnvC accumulates at division sites independently of this essential division

209 ted chromosome masses at the normal mid-cell division site inhibits Z-ring formation and that the SOS

210 ng protein and Mso1 and Sec1 localize to the division site interdependently during cytokinesis.

211 ing that SepF has multiple roles at the cell division site, involving FtsZ bundling, Z-ring tethering

212 Concentration of Rho proteins at the division site is a general feature of cytokinesis, yet t

213 Accurate placement of the bacterial division site is a prerequisite for the generation of tw

214 sembly of the FtsZ ring (Z ring) at the cell division site is negatively regulated by the nucleoid in

215 nesis and that de novo actin assembly at the division site is predominant for contractile ring format

216 The division site is transiently decorated by the cytoskelet

217 osed to guide the cell plate to the cortical division site is unknown.

218 ed and the order of appearance at the future division site is well organized.

219 ow that Pal accumulation at Escherichia coli division sites is a consequence of three key functions o

220 The protein localized to the division site late in mitosis, where it formed a ring th

221 as fully rescued by introduction of cortical division site localized TANGLED1-YFP.

222 which normally depend on FtsK to localize to division sites, localized to division sites in the absen

223 The Min-system primarily determines division site location in the filament, with additional

224 At the division site, most bacteria assemble filaments of the t

225 vision protein leads to the absence from the division site of "downstream" proteins in the pathway.

226 rly spaced "nodes" of TP activity around the division site of predivisional cells.

227 in DivIVA accumulates at cell poles and cell division sites of Gram-positive bacteria.

228 bserved at the distal pole as well as at the division site on both mother and daughter cells; localiz

229 ughter cells as well as near previously used division sites on mother cells.

230 e generated inside the cell to constrict the division site or to haul the rear of the cell forward, r

231 dynamic changes that play important roles in division site placement and possibly other aspects of th

232 ional principles, such as spatial control of division site placement by intracellular protein gradien

233 -to-width aspect ratio, cells exhibit severe division site placement defects.

234 Division site placement in Escherichia coli involves int

235 focus on the MinCD/DivIVA system regulating division site placement in the rod-shaped bacterium Baci

236 Our results suggest that the division site placement is consistent with a Turing patt

237 Our data suggest that division site placement is determined by cortical positi

238 In Escherichia coli, division site placement is regulated by the dynamic beha

239 f the ability to support a normal pattern of division site placement.

240 yeast controls actin filament stability and division site placement.

241 idopsis thaliana, we show that ARC3 mediates division-site placement by inhibiting Z-ring assembly, a

242 Thus, proper control of B. abortus division site polarity is necessary for survival in the

243 Here, we explore the plasticity of division site positioning in fission yeasts Schizosaccha

244 Division site positioning is critical for both symmetric

245 de assembly or disassembly, gross defects in division site positioning result.

246 The division-site positioning defects of gef2Delta plo1-ts18

247 with various cytokinesis mutants involved in division-site positioning, suggesting a role of Nod1 in

248 ive bacteria that localizes at the poles and division sites, presumably through direct sensing of mem

249 s specific proteins to populate the cortical division site prior to disassembly of the preprophase ba

250 elope, PBP5 was also concentrated at nascent division sites prior to visible constriction.

251 ular localisation of the protein to the cell division site, providing evidence of subcellular localis

252 DivIVA and MinD recruit MinC to division sites, rather than mediating the stable polar l

253 The division-site regulators ACCUMULATION AND REPLICATION OF

254 nism is different from those employed by the division site selection antagonists MinC and SlmA.

255 le daughter cells, the mechanisms underlying division site selection have remained largely mysterious

256 The Min proteins that govern division site selection in Escherichia coli may be the f

257 Division site selection in Escherichia coli requires tha

258 Division site selection in rod-shaped bacteria depends o

259 DNA replication, chromosome segregation, and division site selection in the pneumococcus, providing a

260 ia and may be an important component of cell division site selection in these organisms.

261 Spatially, division site selection is one of the most precisely con

262 In Escherichia coli, division site selection is regulated in part by the Min-

263 or of competence ComN, and the regulators of division site selection MinD and MinJ.

264 system results in defects in cell growth and division site selection, and a specific viability defici

265 S/ParB/ParA system directly affects not only division site selection, but also cell growth.

266 lar functions: DivIVA plays diverse roles in division site selection, chromosome segregation and cont

267 inD oscillation behavior, and therefore cell division site selection, may be regulated by membrane ph

268 stion remains as to what drives pneumococcal division site selection.

269 as identified and implicated in pneumococcal division site selection.

270 Tomographic cryoEM images of the cell division site show separate constrictive processes closi

271 is a good understanding of the mechanisms of division site specification in most organisms, and the m

272 ends from the phragmoplast with TAN1 at the division site suggests that TAN1 interacts with microtub

273 ng OM invagination with PG remodeling at the division site than previously appreciated.

274 al and have higher levels of Rho1-GTP at the division site than wild-type cells.

275 P) Rga1 establishes an exclusion zone at the division site that blocks subsequent polarization within

276 ein FtsZ into a ring (Z-ring) at the nascent division site that serves as a foundation for assembly o

277 However, instead of polarizing at the division site, the new polarity axis is directed next to

278 ses with the plasma membrane at the cortical division site, the site of the former PPB.

279 ocalize with PPBs and remain at the cortical division site through metaphase.

280 ions, lead instead to rapid lysis at nascent division sites through a process that requires the compl

281 cruitment of many additional proteins to the division site to form the mature divisome machine.

282 The arrival of FtsN at the division site triggers synthesis of septal peptidoglycan

283 nd the protein Inn1 are all delivered to the division site upon mitotic exit even when the AMR is abs

284 ks phragmoplast microtubules to the cortical division site via actin filaments.

285 rgeting and activation of Rho1 (RhoA) at the division site via Rho1 guanine nucleotide exchange facto

286 s cerevisiae, and that Myo1 localizes to the division site via two distinct targeting signals in its

287 tion of DnaK-GFP to poles and potential cell division sites was dependent on elevated growth temperat

288 ther and daughter cells; localization to the division sites was persistent through multiple cell cycl

289 ments indicate that EnvC is recruited to the division site well before its cognate amidase AmiB.

290 ore frequent Cdc42 repolarization within the division site when the first temporal step in G1 is assu

291 where they are active during growth, to the division site where they build the partition between dau

292 aments under the cytoplasmic membrane at the division site where, together with other proteins it rec

293 ane protein that localizes to the polar cell division sites where it causes FtsZ to relocate from mid

294 Tol-Pal is recruited to cell division sites where it is involved in maintaining the i

295 dozen (known) proteins that localize to the division site, where they direct assembly of the divisio

296 main mediates dynamic localization to active division sites, whereas the assembly of a stable focus a

297 ition of LysM-type murein hydrolases to cell division sites, which was associated with defects in cel

298 Hof1 colocalizes at the cell division site with the septin complex and, as mitotic ex

299 is necessary for the proper placement of the division site within the cell.

300 1 is involved in preventing rebudding at old division sites, yet how these proteins and Rga1 might fu