ライフサイエンスコーパス: dogma

1 on, in particular what he called the central dogma.

2 ated enzyme chemistry underlying the central dogma.

3 in regulating multiple nodes of the central dogma.

4 unity ecology and speciation challenges this dogma.

5 bsence of Foxp3(+) Tregs, countering current dogma.

6 ocess of protein synthesis along the central dogma.

7 ivax and Plasmodium ovale malaria has become dogma.

8 etical analysis that starts with the Central Dogma.

9 zation beyond the dark level, now a textbook dogma.

10 language of genes, mutants, and the central dogma.

11 he study of the main machines of the central dogma.

12 n intracellular compartments challenges this dogma.

13 lling into question this long-standing lunar dogma.

14 eins; however, recent studies challenge this dogma.

15 or gene silencing, contrary to long accepted dogma.

16 revising the mammalian rod/cone bipolar cell dogma.

17 perspective on tau challenges long-standing dogma.

18 he molecular mechanism is different from the dogma.

19 speak for themselves is fast becoming a new dogma.

20 Here we challenge this dogma.

21 s, energy metabolism, regulation and central dogma.

22 a striking observation that challenges this dogma.

23 tive immunity, which led us to question this dogma.

24 ioperative management may have changed these dogmas.

25 ylotrophy and the challenge of long-standing dogmas.

26 These advances have overturned two long-held dogmas: (1) only adaptive immunity confers immunological

27 In contrast to the current dogma, a longitudinal study of conditional Ift88 cilia m

28 We show that, contrary to current dogma, a significant part of the dermal lymphatic vascul

29 The prevailing dogma about neurogenic regulation of vascular tone consi

30 l yeasts, a recent study also challenged the dogma about the absence of DNA methylation in yeast spec

31 ntial immune-neural interactions is revising dogmas about their insular actions and revealing that im

32 The dogma according to which alpha-catenin bridges cadherin.

33 onstrate that, in contrast to the prevailing dogma, acetylation of H3 K56 does not directly affect th

34 Here we review current dogma and argue that it is time to delineate novel immun

35 treatment for FXS have been challenging the dogma and principle of the national NBS program: screen

36 dult "two-tier" hierarchy challenges current dogma and provides a revised framework to understand nor

37 ontrols information flow through the central dogma and provides unique opportunities for manipulating

38 te an essential underlying assumption of the dogma and question the specificity of FoxP3-based Treg d

39 h three key findings that challenge existing dogma and suggest new paths.

40 challenge the "one toxin for one antitoxin" dogma and suggest that M. tuberculosis may enlist a soph

41 he recent past, which challenges traditional dogma and ushers in a new era of understanding with pote

42 The results have challenged established dogmas and it is therefore timely to integrate new data

43 rs ago, going against a number of entrenched dogmas, and yet succeeding against many odds and obstacl

44 Current dogma asserts that ubiquitin is typically covalently att

45 ction is well established in plants, current dogma assumes that in animals, intact fertile sperm with

46 indings show that contrary to the prevailing dogma, astrocyte scar formation aids rather than prevent

47 han that of Smad4(CKO) mice, challenging the dogma, at least in chondrocytes, that Smad4 is required

48 promoter methylation, challenging the common dogma based on bulk data.

49 nological advances, not only is the existing dogma being challenged, but we are identifying new disea

50 e strains of Agrobacterium, with the current dogma being that no functional VirF is encoded by nopali

51 We have deliberately violated this dogma by constructing a recombinant influenza virus stra

52 005 study by Stewart et al. [5] reversed the dogma by demonstrating that Escherichia coli were suscep

53 is issue by Joshi and colleagues upsets this dogma by identifying several bacterial species that do n

54 We challenge this dogma by mathematical modeling and with experimental evi

55 NA expressivity, are challenging a series of dogmas concerning the nature of the genome and the relat

56 Existing dogma defines mucous phenotypes in asthma and chronic ob

57 context dependent and did not conform to the dogma derived from ectopic expression studies.

58 Dogma dictates that adipocytes are 'passive' cells that

59 Based on previous T-cell studies, current dogma dictates that LAT1 is required for plasma membrane

60 exit sites in deeper lymph node venules, as dogma dictates, has a dominant function in antiviral CD8

61 According to three widely held dogmas, DNA is the unchanging template of heredity, is i

62 However, contrary to current dogma, electrogenic transport is not rate-limiting for w

63 Contrary to dogma, evolutionarily young and dynamic genes can encode

64 Contrary to dogma, FHL-1 and FH exhibited equal regulatory activity,

65 The current dogma for cell wall polysaccharide biosynthesis is that

66 A dogma for DNA polymerase catalysis is that the enzyme bi

67 A similar central dogma for guiding and unifying nanoscience has been miss

68 The present CRISPR/Cas9 gene editing dogma for single guide RNA (sgRNA) delivery is based on

69 hat coupling the two genes along the central dogma forces the fluctuations to propagate and accumulat

70 Our approach indicates that, contrary to dogma, frequent mixing occurs in low transmission region

71 However, in the last decade this dogma has been challenged by new findings on non-coding

72 ood pressure circadian rhythm; however, this dogma has been challenged by the discovery that each of

73 The common dogma has been that phosphorylation of the hydrophobic m

74 Dogma has held that lamins B1 and B2 play unique and ess

75 Dogma has held that these ANGPTLs inactivate LPL by conv

76 Alphavirus dogma has long dictated the production of a discrete set

77 This developmental dogma has recently been questioned by nonverbal ToM task

78 Conventional dogma has regarded E-cad as a metastasis-suppressor gene

79 ange of growth rates, we report that neither dogma holds in either the slow- or fast-growth regime.

80 Prevailing dogma holds that activation of the beta-adrenergic recep

81 Prevailing dogma holds that cell-cell communication through Notch l

82 Current dogma holds that the heart balances energy demand and su

83 Current dogma holds that the Rpt(1-6) unfolding ring of the 19S

84 However, the broad applicability of this dogma in clinical disease is only partially understood.

85 amyloid hypothesis has long been the central dogma in drug discovery for Alzheimer's disease (AD), le

86 A dogma in ecology and evolution holds that the environmen

87 A prevailing dogma in sedimentation analysis is that the weight-avera

88 This finding goes against firmly entrenched dogma in showing that HKT proteins can function as both

89 These findings depart from current dogma in the field by identifying a unique effect of TLR

90 Thus, the prevailing dogma in the field is that Cos2 functions solely as a sc

91 such a widespread belief that it approaches dogma in the field of drug discovery and optimization an

92 Contrary to the current dogma in the field that Pseudomonas aeruginosa is the do

93 This binding selectivity revises the dogma in the field.

94 he aim of the current study was to test this dogma in the least shrew model of vomiting.

95 These results overturn a long-standing dogma in the study of sensorineural hearing loss and hig

96 Current dogma indicates that stress granules function as inert s

97 processing sequence described by the central dogma information flow (CEDIF).

98 According to dogma, initiator caspases are activated through proximit

99 suggest that it is necessary to rethink the dogma involving GAS pathogenesis, and that the most prod

100 Additionally, dogma is being challenged by data showing very low and e

101 ong-standing problems in science or refuting dogma is not necessarily the best strategy for a young i

102 Confirmation of this dogma is observed in guideline-directed use of neurohorm

103 The inevitable derivative of this dogma is that every invasive carcinoma is in fact a miss

104 The prevailing dogma is that hospital treatment is administered as need

105 The longstanding dogma is that humans exhibit an acute reduction in haemo

106 Current dogma is that inflammation in SpA initiates in the gut a

107 A prevailing dogma is that inhibition of vascular thrombosis by antag

108 oth nanoparticulates and matrix; the popular dogma is that long-lived, high-affinity bonds to both sp

109 The current dogma is that obesity-associated hepatic inflammation is

110 The current dogma is that stress-induced phosphorylation activates t

111 A well accepted dogma is that TCF7l2 inhibits oligodendrocyte differenti

112 The dogma is that the mitotic spindle governs the assembly a

113 The prevailing dogma is that thermogenic brown adipose tissue (BAT) con

114 Current dogma is that these effects reflect a role for LH neuron

115 fragment crystallizable (Fc) region, and the dogma is that this protects the bacteria against phagocy

116 One such dogma is the adenoma-carcinoma sequence and that a multi

117 The only exception to this dogma is the fusogenic reoviruses that encode fusion-ass

118 The 'dogma' is that IgE molecules merely sensitise mast cells

119 proteins, a network known as life's central dogma, is now marvellously complex, and the progressive

120 over, in contrast to the previous prevailing dogma, it is now widely accepted that circulating immune

121 lexes only with one 12-RSS and one 23-RSS, a dogma known as the 12/23 rule that governs the recombina

122 These data suggest that current dogma may be incorrect.

123 esults indicate that, in contrast to current dogma, Mdm2 expression is required for cell survival eve

124 Here, we show that, contrary to dogma, MMTV-Wnt1 mammary tumors with mutant p53 exhibite

125 We now report that this long-standing dogma no longer pertains, provided additional mutations

126 Contrary to dogma, no correlation between the GR monomeric/dimeric s

127 The classical dogma of "diabetic nephropathy" progressing through stag

128 This blurs the existing dogma of a clear distinction between stationary nups and

129 adult human ovaries, thereby reinforcing the dogma of a limited ovarian reserve.

130 e is perceived, and represent a shift in the dogma of allergic disease development.

131 owledge leading to a revision of the current dogma of artemisinin biosynthesis in A. annua but also m

132 nd genes, and the elucidation of the central dogma of biology.

133 The dogma of coupled transcription and translation in bacter

134 of the helical structure of DNA, the central dogma of DNA to RNA to protein, and the genetic code.

135 The established dogma of endochondral bone ossification is that hypertro

136 The central dogma of gene expression (DNA to RNA to protein) is univ

137 The central dogma of gene expression is that DNA is transcribed into

138 ecomes prevalent with age and highlights the dogma of HSC regulation by their progeny.

139 A dogma of innate immunity is that neutrophils use G-prote

140 uccinct evidence to refute the long-standing dogma of interplastid connectivity.

141 tion in cancer, organized around the central dogma of molecular biology (i) at the DNA level with gen

142 ing quantitative descriptions of the central dogma of molecular biology and the demonstration that a

143 The central dogma of molecular biology describes the translation of

144 A classical dogma of molecular biology dictates that the 3D structur

145 A central dogma of molecular biology is that the sequence of a pro

146 The central dogma of molecular biology states that DNA makes RNA mak

147 The central dogma of molecular biology states that the flow of genet

148 s of new proteins, a key step in the central dogma of molecular biology, has been a major biological

149 , providing a new way to look at the central dogma of molecular biology.

150 ts represent distinct aspects of the central dogma of molecular biology.

151 tant aspects to understanding of the central dogma of molecular biology.

152 tion of thiamin metabolism is not the simple dogma of negative feedback control.

153 is observed, in the latter case breaking the dogma of ortho metalation.

154 llectively, these data challenge the current dogma of PE trafficking and demonstrate that PE made in

155 ole for p23, contrasting with the historical dogma of restricted cytosolic activities for molecular c

156 The mesolimbic hypothesis has been a central dogma of schizophrenia for decades, positing that aberra

157 This finding appears to go against the dogma of secondary structure being a key determinant of

158 into mammals is a relatively rare event, the dogma of the B allele being especially restricted is mis

159 The prevailing dogma of the role of astrogliosis in inhibition of axona

160 The current dogma of these two immune checkpoint pathways has regard

161 Together, our findings challenge current dogmas of both normal spine development as well as spine

162 s can exist, uniting the often contradictory dogmas of DNA overstretching.

163 his observation underlies one of the central dogmas of T cell biology: because thymocytes are seeming

164 rter than control myelin, vitiating accepted dogmas of what constitutes regenerated myelin.

165 work, we suggest that the so-called "central dogma" of amyloid formation, where aggregation takes pla

166 ecent revelations is challenging the current dogma on how ubiquitin-dependent processes culminate in

167 his issue of the JCI, two groups have turned dogma on its head by providing evidence for alternative

168 indings necessitate changes to long-standing dogma on mechanisms for LPL inactivation by ANGPTL prote

169 hether the "Wigglesworthia-Sodalis-Wolbachia dogma" operates across species and populations.

170 In stark contrast with previous dogma, our study suggests that dolichodial and iridomyrm

171 at panel, e.g. subsystems within the central dogma panel include transcription, translation and prote

172 Current dogma posits that CRLs first catalyze UB transfer from a

173 A long-held dogma posits that strong presentation to the immune syst

174 Although dogma predicts that under normal circumstances, potentia

175 tJ, rho, and rpsQ help protect these central dogma processes in the presence of ethanol.

176 Long-standing dogma proposes a profound contribution of membrane bindi

177 The plant flavonoid dogma proposes that labile plant flavonoid carbocations

178 s impacting information flow through central dogma, providing a framework for quantifying the effect

179 esearch, where the aim is to affirm existing dogmas rather than to pioneer efforts involving unconven

180 ry bladder has fundamentally changed current dogma regarding the urinary tract and related urinary di

181 According to current dogma, regulation of the Egr1 expression takes place pri

182 tissue macrophages in the steady state, the dogma remains that tissue macrophages derive from monocy

183 A dogma set forth by early anatomical studies is that bipo

184 These dogmas spurred many efforts to understand their molecula

185 like for other enteric viruses, the current dogma states that astroviruses infect in a species-speci

186 This is important because dogma states that HIV-1 mutates to evade host recognitio

187 Current dogma states that the fibroblast makes up the largest ce

188 The current dogma states that the molecular basis of the disease-ass

189 However, the current dogma states that the segmentation of the mature neutrop

190 Current dogma suggests risk is greatest in seropositive recipien

191 Current dogma suggests that AAs have worse survival following SP

192 Dogma suggests that antibiotics ineffective as monothera

193 Dogma suggests that atherosclerotic plaques expand prima

194 Current dogma suggests that chronically demyelinated axons are a

195 Current dogma suggests that CM results from infected RBC (iRBC)

196 Current dogma suggests that following specification from mesoder

197 Current dogma suggests that high-energy-consuming photoreceptors

198 Current dogma suggests that most, if not all, Tmem responses are

199 Current dogma suggests that oligomeric alphaSyn intermediates ma

200 Current dogma suggests that salivary gland homeostasis is stem c

201 Current dogma suggests that the murine fetal intestinal epitheli

202 In contrast to the dogma surrounding allosteric modulators, the results ind

203 ory roles for C3a and challenges the general dogma surrounding C3a, which, historically, has ubiquito

204 These studies challenge the long-standing dogma that "a calorie is just a calorie" and suggest tha

205 ying virion morphogenesis and challenges the dogma that "capsid maturation," and therefore the capsid

206 by autoinhibition and challenge the current dogma that all class I-III Fic domain proteins are inhib

207 findings challenge the currently prevailing dogma that all initiator procaspases require homodimeriz

208 y autonomous photoreceptors, overturning the dogma that all visual information originates with rods a

209 Our results challenge the dogma that AMs are short lived and suggest that these di

210 Therefore, the dogma that an asymptomatic primary tumor never should be

211 Contrary to the accepted dogma that ATP is the canonical phosphate donor in amino

212 Taken together, these results question the dogma that autocrine HH signaling plays no role in HH-de

213 This breaks the dogma that beta-lactams enter Gram-negative bacteria onl

214 ings suggest that in contrast to the current dogma that Ca(2+) release via IP3R does not participate

215 The longstanding dogma that cholesterol (chol) autoxidation gives chol 7-

216 The old dogma that CNS neurons cannot be regenerated in the adul

217 er with other recent examples, challenge the dogma that codon optimization primarily increases transl

218 evidence to dispel the antibiotic discovery dogma that conserved proteins do not make good antibioti

219 intracellular pathogen concept can become a dogma that constrains thinking and oversimplifies comple

220 This phenomenon not only challenges the dogma that Cox-1 is only developmentally regulated, but

221 ng of SCFs in human cells and challenges the dogma that E3s alone determine substrate specificity.

222 These findings overturn the 50-year-old dogma that enteroviruses use a single-polyprotein gene e

223 he lack of published evidence supporting the dogma that ex vivo culture generates artifactual genetic

224 tors act as GPCRs in plants, challenging the dogma that GPCRs are exclusively 7TM proteins.

225 ll, our measurements counter the traditional dogma that growth during mitosis is negligible and provi

226 Several strands of evidence question the dogma that human mitochondrial DNA (mtDNA) is inherited

227 l and colleagues challenged the Watson-Crick dogma that hydrogen bonds between complementary bases ar

228 Our data challenge the dogma that IL-23 and Th17 plasticity are universally req

229 ctively neutralize virus alters the existing dogma that influenza virus neutralization is mediated so

230 bgroup of patients with T2D, we question the dogma that IR is primarily harmful to the body and shoul

231 phage phenotype, and they also challenge the dogma that KCs are purely proinflammatory in NASH.

232 shotgun sequencing, clearly challenging the dogma that mid-depth shotgun recovers more diversity tha

233 These materials break the dogma that MOFs must be prepared from small, rigid ligan

234 Does the dogma that multiple myeloma is incurable still hold?.

235 These data challenge the conventional dogma that MuRF1 is controlling the degradation of only

236 Despite long-standing dogma that Na(+)/H(+) antiport regulates pH during the p

237 sed and active in the brain, challenging the dogma that neuronal genomes are static and revealing tha

238 gnaling and significantly expand the current dogma that NIK is predominantly cytosolic and exclusivel

239 acellular chloride, challenging decades' old dogma that NLC reports on eM steady-state behavior.

240 Taken together, these findings challenge the dogma that nuclear accumulation of SAPKs is a pre-requis

241 Shattering the long-held dogma that organolithium chemistry needs to be performed

242 D45- and CD45+ populations and challenge the dogma that Osx is expressed exclusively in cells of mese

243 In contrast to the current dogma that overcoming apoptosis is an important step tow

244 ning during infancy, challenging the current dogma that PFC is an underdeveloped brain system until a

245 Kim et al. challenge the dogma that phosphatidylinositol synthesis is restricted

246 Prior to this discovery, it was dogma that protein glycosylation was restricted to the l

247 The historic dogma that reLT results in inferior outcomes should be r

248 However, the long-standing dogma that reticulate evolutionary processes are likewis

249 within the retina, a notion that refutes the dogma that RGCs only provide physiological signals to th

250 In vivo studies have now overturned the dogma that robust plasticity is limited to an early crit

251 nction in experimental models challenges the dogma that RV failure is irreversible without regression

252 Emerging evidence has challenged the dogma that sensing of viral DNA occurs exclusively in su

253 Anfinsen's dogma that sequence dictates structure is fundamental to

254 Our data also challenge the dogma that shorter forms of beta-endorphin do not exhibi

255 nt in diverse bacteria, thus challenging the dogma that such organisms do not use copper in this loca

256 mmary the present study offers weight to the dogma that the adult ovary is populated by a fixed numbe

257 However, the dogma that the apoptotic nuclear morphology depends on D

258 These findings challenge the simplistic dogma that the mere absence of "healthy" lactobacilli is

259 enes in germinal initials challenges current dogma that the mitotic to meiotic transition occurs late

260 urons and glia, a concept that shattered the dogma that the nervous system lacked regenerative power.

261 last decade, new evidence has challenged the dogma that the ovary is the main source of this cancer.

262 Dogma that the regulatory T cell (Treg) prevents catastr

263 It is likely linked to the long-standing dogma that the rodent islet has a mantle of non-beta-cel

264 The dogma that the synaptic cleft acidifies during neurotran

265 rent approaches, resulting in more or less a dogma that the two branches progress almost independentl

266 udies are generally predicated on Anfinsen's dogma that there is a unique native state of a protein.

267 deficient in LCs have begun to challenge the dogma that there is a universal requirement for these ce

268 This has led to the long-held dogma that these characteristic protein inclusions, whic

269 Contrary to the dogma that these enzymes use ATP as the source of phosph

270 Pase-activating proteins also challenged the dogma that these negative Rac regulators solely act as t

271 These results challenge the current dogma that thymocytes cannot self-renew, and indicate a

272 s surprising considering that it is accepted dogma that TPR proteins do not undergo large conformatio

273 These findings directly refute the dogma that TSPO is indispensable for steroid hormone bio

274 dogenous bioregulators and break the current dogma that vitamin D is solely activated through the seq

275 l cycle studies relies on two interconnected dogmas that were proposed more than 50 years ago-the Sch

276 ur data demonstrate, contrary to established dogma, that loss of haematopoietic-derived focal adhesio

277 ose, the greater the response, following the dogma "the dose makes the poison".

278 Contrary to prevailing dogma, the formed human epicardium is not a simple squam

279 In contrast to the current dogma, the mTOR pathway was not activated in all TSC2(+/

280 ference of New Ideas in Cancer - Challenging Dogmas." The aim of the conference was to take an honest

281 Science is marked by the death of dogmas; the discovery that adipocytes are more than just

282 According to current dogma, there is little or no ongoing neurogenesis in the

283 Thus, in contrast to current dogma, these data demonstrate that increased transcripti

284 According to the current dogma, they are involved in eliminating bacteria, after

285 Opposing this conventional dogma, this study reveals a much higher level of WSX1 ex

286 We previously challenged this dogma to demonstrate a second non-ES(E/D)V PSD-95-bindin

287 doubling times below 1 h, extension of these dogmas to the slow-growth regime has not been consistent

288 This dogma was challenged by recent reports that myeloid cell

289 Recently, dogma was challenged in a report demonstrating oral insu

290 a stochastic two-state model of the central dogma was constructed and verified using joint mRNA/prot

291 This dogma was recently challenged by stable isotope labeling

292 hogenesis of several diseases, the 1980s-90s dogma was that contraction-induced radical production wa

293 Contrary to the prevailing dogma, we find islet morphology and endocrine differenti

294 Additionally, in contrast to the dogma, we find that the major Crohn's disease-associated

295 Contrary to current dogma, we show that both efficient DNA cross-linking and

296 radigm complements the current mitochondrial dogma, whereby molecules endogenously present on or insi

297 Contrary to current dogma, which avers that this is a T-cell defect, we demo

298 Li et al. challenge this dogma with evidence that all three of these programs are

299 s have seen a revolution in these prevailing dogmas, with a significant contribution made by the auth

300 Thus, contrary to the prevailing dogma, wrapping by the erythrocyte combined with parasit