ライフサイエンスコーパス: domain architecture

1 full-length sequence similarity with common domain architecture).

2 ood are WHAMM and JMY, two NPFs with similar domain architecture.

3 Each subunit shows a domain architecture.

4 hat is consistent with GAK's multifunctional domain architecture.

5 C heterodimer and determine its higher-order domain architecture.

6 cture revision required us to reconsider the domain architecture.

7 binding does not extend to the overall multi-domain architecture.

8 izosaccharomyces pombe Rhp23, has an unusual domain architecture.

9 ain was inserted interior to the existing NR domain architecture.

10 ith those in other CFs that contain the same domain architecture.

11 ith each subfamily sharing a common, modular-domain architecture.

12 despite not being part of the canonical BLUF domain architecture.

13 to evaluate how well an algorithm recovers a domain architecture.

14 aprioi knowledge of family relationships or domain architecture.

15 n and does not require a priori knowledge of domain architecture.

16 new protein sequences into families based on domain architecture.

17 ilarities, and a graphical representation of domain architecture.

18 nt, Delta(187-243), to obtain information on domain architecture.

19 n the interfaces involved but also different domain architecture.

20 ting a conserved strategy for organizing the domain architecture.

21 th the number of proteins involved and their domain architecture.

22 of a conserved family characterized by a two-domain architecture.

23 are distantly related to BoNTs with similar domain architecture.

24 implying an evolutionary advantage for this domain architecture.

25 s of some of these insects and studied their domain architecture.

26 Light Chain, a membrane protein with a novel domain architecture.

27 rised according to taxonomic distribution or domain architecture.

28 CoA mutase (MCM), HCM has a highly conserved domain architecture.

29 13 (PBL13), a subfamily VII RLCK with unique domain architecture.

30 allows a priori design of these hierarchical domain architectures.

31 ganismal complexity by the generation of new domain architectures.

32 provide highly comprehensive composite multi-domain architectures.

33 searching genomes to identify related multi-domain architectures.

34 nce alignments based on commonality of multi-domain architectures.

35 ins that share highly conserved features and domain architectures.

36 th an extraordinary diversification of their domain architectures.

37 nerates a dynamic 2D network of related Pfam domain architectures.

38 ompare heterodimers of chains with different domain architectures.

39 a bank (PDB) are grouped based on their PFAM domain architectures.

40 ies, were identified and classified by their domain architectures.

41 implifies the visual analysis of represented domain architectures.

42 ence motifs, shared structural features, and domain architectures.

43 d in the generation of many lineage-specific domain architectures.

44 ized into 22 classes based on their specific domain architectures.

45 by cyclodextrin disruption of PM lipid micro-domain architecture, a change that also retarded lateral

46 are represented by orthologs with conserved domain architecture across the three superkingdoms of li

47 other genomes or groups of genomes; compare domain architectures across selections of genomes and fi

48 This domain architecture allows coordinated assembly of prote

49 The TraI domain architecture, although not previously described,

50 many RabGAPs share a Tre-2/Bub2/Cdc16 (TBC)-domain architecture, although the majority of TBC protei

51 Pases of ESX secretion systems have a unique domain architecture among proteins of the FtsK/SpoIIIE f

52 Genomic context and domain architecture analyses support a role for the GxGY

53 ng the relationships between related protein domain architectures, analyses of ligand binding cluster

54 sequence alignment, structure prediction and domain architecture analysis, we have identified a novel

55 ad options provide improved functionality to domain architecture analysis.

56 ps between homologous proteins, (ii) protein domain architecture and (iii) gene neighborhoods the cor

57 We observe an alphabeta-roll domain architecture and a dimeric assembly which are con

58 ribosomal peptide synthetase with an unusual domain architecture and an L-threonine:4-nitrophenylacet

59 ss II fusion proteins have a conserved three-domain architecture and are found in many important vira

60 ctures also provide no information on ATPase domain architecture and ATP hydrolysis.

61 The superfamily curation defines signature domain architecture and categorizes memberships to impro

62 ystematically review the expression profile, domain architecture and chemical tractability of human E

63 The two-domain architecture and dimerization of MinC can be rati

64 The domain architecture and DNA recognition profile displaye

65 nd PRO units adopt the highly-conserved PRMT domain architecture and form an antiparallel heterodimer

66 Our results show that VACV-A6 has a two-domain architecture and functions in both crescent forma

67 We use bioinformatics to examine the domain architecture and gene neighborhood of T4aP secret

68 llography, we obtained new insights into the domain architecture and interaction network of the Cep10

69 cleoside contributions to the tRNA anticodon domain architecture and its decoding of the genome has a

70 Based on domain architecture and phylogenetic analyses grape home

71 Despite a domain architecture and positioning of catalytic residue

72 oscopy analysis demonstrate a highly dynamic domain architecture and provide the foundation for under

73 w families of transcription factors based on domain architecture and receive predictions for a protei

74 de query sequence the server will return the domain architecture and SCOP classification.

75 ture of the BT_1012 protein confirms its two-domain architecture and structural analysis of both doma

76 ruling out a simple correlation between SurA domain architecture and these properties of OMP sequence

77 The web interface includes services such as domain architectures and alignment details for all prote

78 domains show a tendency to occur in diverse domain architectures and can be considered "promiscuous.

79 b) have been studied in detail, the distinct domain architectures and diverged RuvC sequences of unch

80 ein (MCP) homologs that have diverse sensing domain architectures and generate a potential for sensin

81 characterize protein families via conserved domain architectures and has built up a significant corp

82 Comparison of domain architectures and multiple alignments resulted in

83 e of life, searches for functionally similar domain architectures and phylogenetic trees.

84 ence (information gain) between the observed domain architectures and random domain combinations is h

85 ies in our test set exhibit a broad range of domain architectures and sequence conservation, demonstr

86 s of phylogenetic profiles, genomic context, domain architectures and sequence identity reveal that s

87 nd MX2 are closely related and share similar domain architectures and structures.

88 The diversity of domain architectures and the abundance of alternative do

89 ats of Rad4(TopBP1), revealing a distinctive domain architecture, and characterized their phosphoryla

90 ces to other databases, graphical display of domain architecture, and links to multiple sequence alig

91 otein membership, parent-child relationship, domain architecture, and optional description and biblio

92 e analyses of protein families via conserved domain architectures, and a recent curation effort focus

93 oups of transcription factors have identical domain architectures, and this implies that roughly thre

94 embers of the protein phosphatases family by domain architecture as an ontology.

95 The structures have a three-domain architecture as observed previously for other gly

96 BtGH115A reveals that BtGH115A has the same domain architecture as the other structurally characteri

97 ests mammalian lipins function with the same domain architecture as Tt Pah2.

98 s provide a framework to rationalize the LOV domain architecture, as well as the signaling mechanisms

99 ins described to date share a common helical domain architecture at the N-terminus that typically int

100 eveal not only a novel chemoreceptor sensing domain architecture but also, possibly, a different mech

101 SP25 and USP28 comprise an identical overall domain architecture but are functionally non-redundant:

102 TRIM proteins have conserved domain architecture but diverse cellular roles.

103 5/OTT1, and RBM15B/OTT3 share the structural domain architecture but show distinct functional propert

104 y from CCP tandems, suggesting that not only domain architectures but also cleavage location can be c

105 the widespread four-helix bundle cytoplasmic domain architecture can control VGIC responses, uncover

106 and demonstrates how variations in a single domain architecture can modulate binding to a specific l

107 networks by which zoonotic receptor binding domain architecture can productively engage hACE2, but o

108 Search results are displayed as domain architecture cartoons and pairwise alignments bet

109 function of a NRPS-like enzyme with unusual domain architecture, catalyzing two sequential two-elect

110 Knowledgebase (UniProtKB) by comparing their domain architectures, classifying proteins based on the

111 The hIKK2 domain architecture closely resembles that of Xenopus IK

112 lus Gfh1 at 2.4 A resolution revealing a two-domain architecture closely resembling that of GreA.

113 - and O-glycosylated catalytic domain (CD)-a domain architecture common to many biomass-degrading enz

114 The structure contains a bi-domain architecture composed of a GAF domain (commonly f

115 The minimal consensus domain architecture comprises a signal peptide, a 60-90-

116 Netrin G proteins share a common multi-domain architecture comprising a laminin N-terminal (LN)

117 uitinating enzymes exhibit a conserved three-domain architecture, comprising Fingers, Palm, and Thumb

118 I-D Cas10d large subunit exhibits an unusual domain architecture consisting of a Cas3-like HD nucleas

119 P4 has a two-domain architecture consisting of a core alpha/beta doma

120 uginosa chemoreceptor, Aer-2, has an unusual domain architecture consisting of a PAS-sensing domain s

121 ata revealed MrkH to be a monomer with a two-domain architecture consisting of a PilZ C-domain connec

122 CheB has a two-domain architecture consisting of an N-terminal regulato

123 It has a modular domain architecture consisting of an Src homology 2 doma

124 The structures reveal a two-domain architecture containing a Toprim domain with alte

125 study was to analyse the protein domain and domain architecture content of the 137 fungal proteomes

126 First, we compared the domain and domain architecture content of the human and fungal prot

127 y universal value of information gain by the domain architectures could reflect the minimum complexit

128 how that, despite appreciable differences in domain architecture, Csk from Corallochytrium limacispor

129 ary sequence conservation, protein size, and domain architecture, deemed ELMOD and ELMO.

130 of the NCBI Entrez Protein Database based on domain architecture, defined as the sequential order of

131 The effector collection and network of domain architectures described here can serve as a roadm

132 her identify a chemoreceptor with an unusual domain architecture, DosM, which is essential for format

133 Some layered domain architectures (e.g. mainly-beta and alpha-beta sa

134 om a common ancestor and instead suggest the domain architecture evolved at least twice.

135 share core light-input and signaling-output domain architectures except for the loss of C-terminal r

136 PGTs that reveals a core structure with dual domain architecture featuring a C-terminal soluble globu

137 sigma(E)/ChrR complex reveal a modular, two-domain architecture for ChrR.

138 notated sequence regions to derive consensus domain architecture for each sequence and subsequently g

139 that have fused C-terminal TE domains, a new domain architecture for fungal HRPKSs.

140 e, we propose a higher-resolution functional domain architecture for nsp3 that determines the interac

141 me encodes apparent orthologs with conserved domain architecture for the majority of the disease gene

142 Prediction and comparison of TLR protein domain architectures for multiple species revealed seven

143 ms for a domain superfamily or all the multi-domain architectures for the human genome.

144 Prediction and comparison of protein domain architectures for TLR2 and TLR6 revealed six regi

145 ned in membranes; (iv) amino acid sequences, domain architecture, functional annotation and available

146 es only the presence or absence of a protein domain architecture has been used to determine the phylo

147 Further, TBC-domain architecture has been well conserved in modern eu

148 Their domain architecture has remained relatively fixed across

149 enzyme (BstCCA) have similar dimensions and domain architectures (head, neck, body, and tail), only

150 inherent dynamics of SSBs and PARP-1's multi-domain architecture hindered structural studies.

151 r results demonstrate that the multiple HRDC domain architecture in GcRecQ is critical for structure-

152 cterial multidrug exporter Sav1866 suggest a domain architecture in which both nucleotide-binding dom

153 we analyzed the presence of ABCFs and their domain architectures in 4505 genomes across the tree of

154 niversal grammar" underlies the evolution of domain architectures in all divisions of cellular life.

155 two or more smaller proteins with equivalent domain architectures in other organisms.

156 has built up a significant corpus of curated domain architectures in support of naming bacterial prot

157 igh degree of homology and have very similar domain architecture, including an amino terminal GTPase

158 recruits to sites of DNA damage where PARP-1 domain architecture initiates catalytic activation and s

159 gene/protein sequence retrieval, visualized domain architectures, interactive chromosomal views for

160 If the CSP domain architecture is altered such that the cell-adhesi

161 den Markov model-based sequence profiles and domain architecture is calibrated against manually curat

162 This three-domain architecture is compatible with interactions betw

163 The fold is similar to FIS protein, but the domain architecture is different from previously charact

164 The alpha CTD DNA-binding domain architecture is unlike any DNA-binding architectu

165 s a molecular mechanism by which conserved G domain architecture is used to energetically link GTP tu

166 ght into the GT64 domain, the rest of the bi-domain architecture is yet to be characterised; hence, h

167 ulting list of core and exclusive domain and domain architectures is provided in this paper.

168 nthase (PKS) is quite complex, with a simple domain architecture leading to elaborate products.

169 The NLR domain architecture likely evolved independently and con

170 Protein domain architectures link evolutionarily related protein

171 nd 70% on the domain level, unless the multi-domain architecture matches.

172 For example, the three-layer sandwich domain architecture may be divided into four structural

173 nd to dsRNA, which shows how, using the same domain architecture, MDA5 recognizes the internal duplex

174 ower clustering of proteins sharing the same domain architecture, MUSCLE multiple sequence alignment,

175 Domain architecture "neighbors" identified in this way m

176 The domain architecture of a large RNA can help explain and/

177 Furthermore, the domain architecture of a SONO ortholog cloned from Chlam

178 We defined the domain architecture of A6 and suggested that one of its

179 Overall, we have shown that the modular domain architecture of AAA proteins allows for precise c

180 Detailed examination of the domain architecture of aaRSs using sequence profile sear

181 We asked why CFTR, which shares the domain architecture of ABC proteins that function as tra

182 n types by name, for example, or to view the domain architecture of any protein in Entrez's sequence

183 In a previous study, we determined the domain architecture of ataxin-3, suggesting that it comp

184 The domain architecture of CBP and TAF(II)250 families of HA

185 ts of a gene correlated to variations in the domain architecture of corresponding protein isoforms.

186 Overall, the unique domain architecture of Csa3 suggests a transcriptional r

187 DXMS has verified the multi-domain architecture of D-AKAP2 implied by sequence homol

188 This newly revealed domain architecture of DISC1, therefore, provides a powe

189 The domain architecture of full-length XEEL is reminiscent o

190 apid and precise identification of the multi-domain architecture of GHs from various datasets.

191 ts provide an explanation for how the unique domain architecture of JAZ10.4 links transcription facto

192 on the proposed mode of restriction and the domain architecture of known antiretroviral env, we argu

193 Little is known about the functional domain architecture of long noncoding RNAs (lncRNAs) bec

194 A domain-containing proteins with the common domain architecture of N-terminal SRA domain and C-termi

195 lar structure in toxins evolved to match the domain architecture of Na(v)s.

196 The unique domain architecture of NgrRnl fortifies the theme that R

197 Determination of the higher-order domain architecture of NOS is essential to elucidate the

198 CsPABPN1 has a domain architecture of nuclear PABPs (PABPNs) with a sin

199 The domain architecture of PfCDPK7 is very different from th

200 The predicted domain architecture of PrkC comprises a cytoplasmic kina

201 ve lateral organization, fluidity, and lipid domain architecture of protein-free membranes reconstitu

202 s; (ii) color-coded graphical display of the domain architecture of proteins correlated with their co

203 hese analyses reject the hypothesis that the domain architecture of R-proteins and NLRs was inherited

204 experiments, we elucidate how the conserved domain architecture of RecQ supports geometry-dependent

205 Understanding the higher-order domain architecture of sGC is a prerequisite to elucidat

206 of the secondary (2 degrees ) structure and domain architecture of the 23S and 5S rRNAs, using 3D st

207 To define the domain architecture of the A-ATPase peripheral stalk, we

208 By comparing the multi-domain architecture of the enzymes and using sequence si

209 Here we characterize the domain architecture of the heme-independent yeast cystat

210 We present a model of the domain architecture of the PpsR protein according to whi

211 main fold and, at the finest level, with the domain architecture of the proteins containing them, hig

212 In addition, the protein domain architecture of these four TLRs was examined betw

213 The two-domain architecture of type 2 RNase H creates a positive

214 nd fusion event that produced the modern two-domain architecture of vertebrate lens crystallins may b

215 early energetically degenerate, hierarchical domain architectures of coexisting c/a and a1 /a2 domain

216 d highlights the specialization of the multi-domain architectures of DDR-PARPs.

217 By analyzing the domain architectures of fully sequenced var gene reperto

218 that may be reordered, as is common with the domain architectures of proteins.

219 association of domains that generate various domain architectures of proteins.

220 Comparative analysis of the domain architectures of the beta, beta', and sigma(70) s

221 different TFIIB-like proteins and predicted domain architectures of the newly identified TFIIB-like

222 The domain architectures of the protein products of these 64

223 r to view the full structural context (multi-domain architecture) of domains and chains.

224 echanistically similar, PutAs vary widely in domain architecture, oligomeric state, and quaternary st

225 to highlight a chosen superfamily, family or domain architecture on the tree of life.

226 proteomes, and identified those domains and domain architectures only present in fungi.

227 Domain architecture or context is also found to affect s

228 obvious similarities in their extracellular domain architecture or homologies to their cytoplasmic d

229 roteins, the prediction of function based on domain architecture or the presence of sequence motifs a

230 ee different structures form as large single-domain architectures or as multidomain materials.

231 ew experimental studies and information from domain architectures point to several similar mechanisti

232 localization studies, we have clarified the domain architectures, potential biological functions, an

233 Using a data set of domain architectures present in 159 proteomes that repre

234 orphan protein phosphatase that possesses a domain architecture previously only described in Plantae

235 ees are annotated with gene organization and domain architecture, providing insights into the evoluti

236 The taxonomy and domain architecture representations can be used in combi

237 This domain architecture resembles, despite a lack of sequenc

238 nserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART) and the PubCh

239 nserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART) and the PubCh

240 The Conserved Domain Architecture Retrieval Tool (CDART) performs simi

241 nserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART), Biosystems,

242 nserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART), IBIS, Biosys

243 rved Domain Database (CDD) and the Conserved Domain Architecture Retrieval Tool (CDART).

244 rved Domain Database (CDD) and the Conserved Domain Architecture Retrieval Tool (CDART).

245 ved Domain Database (CDD), and the Conserved Domain Architecture Retrieval Tool (CDART).

246 the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool and the PubChem suite

247 the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool and the PubChem suite

248 the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool, Biosystems, Peptidom

249 In particular, the new domain architecture search tool is described and the pro

250 RIM-BPs' conserved domain architecture seemingly provides a relay to guide

251 This region of AphA has a conserved domain architecture similar to that of MarR, a multiple

252 Our results may be used to compute domain architecture similarities, for example, based on

253 ucture of E. coli RF3*GDP, which has a three-domain architecture strikingly similar to the structure

254 The CR(ColIIA) structure manifests a two sub-domain architecture tethered by a flexible linkage.

255 ) (ADP, adenosine diphosphate) has a modular domain architecture that couples DNA damage detection to

256 They share a common domain architecture that features an N-terminal MIT (mic

257 Two of the seven types had a unique domain architecture that has not been discovered previou

258 nct ligand binding modes and a unique kinase domain architecture that has not been observed previousl

259 NOD-like receptors of animals (NLRs) share a domain architecture that includes a STAND (signal transd

260 l structure exhibiting a seven-transmembrane-domain architecture that is clearly distinct from that o

261 rmined to 2.1 A resolution and reveals a two-domain architecture that is responsible for these two re

262 We found that WNV E adopts a three-domain architecture that is shared by the E proteins fro

263 wo regions on its double-pleckstrin homology domain architecture that mediated histone binding.

264 d to the translational factors, with a multi-domain architecture that wraps around a highly distorted

265 families that possess sequence signatures or domain architectures that are conserved in all euryarcha

266 ith respect to in-silico analyses of protein domain architectures that revealed a diverse array of re

267 The IRES features a novel extended, multi-domain architecture, that circles the 40S head.

268 The FOZI-1 protein displays a highly unusual domain architecture, that combines two functionally esse

269 database contains the description of protein domain architecture, the definition of structural neighb

270 nt polypeptide pairs, to assess the proposed domain architecture, the function of the insertional ele

271 The functional probing of the L domain architecture through trans-complementation is ant

272 s immunity, full-length AcrIIA1 uses its two-domain architecture to act as a "Cas9 sensor," tuning ac

273 LepB further employs an unusual tandem domain architecture to clamp a switch I tyrosine in an o

274 thaliana) RING-type E3s that are similar in domain architecture to the rice (Oryza sativa) XA21 Bind

275 Tsr1 has a similar domain architecture to translational GTPases such as EF-

276 vR is a transcriptional regulator that has a domain architecture unique to a select group of methanog

277 the phylogenetic distribution of the NBS-LRR domain architecture, used maximum-likelihood methods to

278 ulting matches are refined into simple multi-domain architectures using a recently developed in-house

279 These contain background information, domain architecture via Pfam links, a list of all sequen

280 One of the new match views is the InterPro Domain Architecture view, which shows the domain composi

281 ts, permitting analysis when chromosome-wide domain architecture was disrupted but most DCC binding r

282 Domain architecture was further studied by limited prote

283 The most ancient domain architectures were hydrolase enzymes and the firs

284 Tt Pah2 adopts a two-domain architecture where the N-Lip combines with part o

285 The protein molecule has a three-domain architecture with a central hydrophobic channel.

286 the GALC-product complex, revealing a novel domain architecture with a previously uncharacterized le

287 essed three types of architectures: a single-domain architecture with an intact asparagine ladder, a

288 PfhB2 shares a common domain architecture with IbpA and contains two Fic domai

289 , show a similar overall seven-transmembrane-domain architecture with large unoccupied cavities and a

290 rity of these proteins have a characteristic domain architecture with one of several N-terminal 'Head

291 HLTF, like SHPRH, shares a unique domain architecture with Rad5 and promotes lysine 63-lin

292 UvsW has a four-domain architecture with structural homology to the euka

293 eceptor that combines the typical eukaryotic domain architecture with the 'TXVGYG' signature sequence

294 These structures reveal a conserved, three-domain architecture with the binding sites for UNAM and

295 state has been determined, and reveals a two-domain architecture with the four characteristic sequenc

296 interrupted in the middle, and a trans-three-domain architecture with the ladder broken in both termi

297 re with an intact asparagine ladder, a three-domain architecture with the ladder interrupted in the m

298 They share a conserved five-domain architecture with three globular domains separate

299 stal structure of SdeAgu115A revealed a five-domain architecture, with an additional insertion C(+) d

300 omain structure of UvrD2 shows a distinctive domain architecture, with an extended C terminus contain