ライフサイエンスコーパス: dominant-negative form

1 izing VEGF receptor signaling by acting as a dominant-negative form and/or forming a nonsignaling dim

2 p85alpha and p85beta or expression of their dominant-negative forms, but not inhibition of PI3 kinas

3 Blocking STAT3 activation with a dominant negative form can rescue the migration defect i

4 , when the cells transiently overexpressed a dominant-negative form (DIII) of Eps15, which is thought

5 r Nrdp1 knockdown or the overexpression of a dominant-negative form enhances ErbB3 levels and cellula

6 on and repress calbindin(+) ACs, whereas its dominant-negative form has the ability to suppress the G

7 , was constitutively nuclear, and acted as a dominant negative form in IRF-5 reporter assays.

8 by inhibitors, small interfering RNAs, or by dominant-negative forms, induced axonal growth cone coll

9 letion of the atlastins or overexpression of dominant-negative forms inhibits tubule interconnections

10 terference, or AKT activity by expression of dominant negative forms, inhibits significantly fetal li

11 Here, we show that expression of a dominant negative form of AMPK or inactivation of AMPK a

12 o-transfection of AP-2alpha wild-type or the dominant negative form of AP-2 lacking its C-terminal DN

13 K(1)R-mediated cell death was inhibited by a dominant negative form of arrestin 2, Raf-1, or Nur77, b

14 ans by using 3-methyladenine, chloroquine, a dominant negative form of ATG4B or silencing Beclin-1, A

15 quitin ligase complex or overexpression of a dominant negative form of beta-TrCP1 enhances p53 stabil

16 Previous studies have shown that a dominant negative form of c-Jun (TAM67) suppresses mouse

17 ession, and inhibition of AP-1 activity by a dominant negative form of c-Jun in primary T cells stron

18 tion was also inhibited by transfection of a dominant negative form of c-Src.

19 uces a gain of function that gives rise to a dominant negative form of CAV1, defining a new mechanism

20 The expression of a dominant negative form of Chd1 results in increased stal

21 f of the CPL4 catalytic domain resulted in a dominant negative form of CPL4, the overexpression of wh

22 nd, in line with these data, expression of a dominant negative form of CREB blocked BDNF-promoted inc

23 of the ET induction of ANTXR revealed that a dominant negative form of CREB could block the ET induct

24 Further, in vitro expression of a dominant negative form of Daxx (DN-Daxx), which binds to

25 A dominant negative form of Derlin-1, an ER protein requir

26 t by tetracycline-controlled expression of a dominant negative form of DNA polymerase gamma causes a

27 on biogenesis was reduced by expression of a dominant negative form of Drosha.

28 onstitutive expression of a GTPase defective Dominant Negative form of DRP2A/B did not allow the reco

29 s, we developed transgenic mice expressing a dominant negative form of Egr-1, which lacks the trans a

30 th wild-type and T-bet-deficient mice with a dominant negative form of Eomes significantly reduced IF

31 are comparable to an adult model that uses a dominant negative form of ErbB4 expressed in the support

32 suppression of ERRs through expression of a dominant negative form of ERR or treatment with a pharma

33 se processes, we analyzed cells expressing a dominant negative form of FAK (dnFAK).

34 Compared to controls, U87 cells expressing a dominant negative form of Fas (dnFas) or overexpressing

35 Overexpression of a dominant negative form of FoxO3a inhibited ethanol-induc

36 data to those with PTX were obtained when a dominant negative form of G(i1alpha) was overexpressed.

37 ate area by 60-170%, whereas expression of a dominant negative form of GC inhibited endogenous aggreg

38 Microinjection of a dominant negative form of Gs into Xenopus and mouse oocy

39 tutively activated form of beta-catenin or a dominant negative form of GSK3-beta converted all or nea

40 The N-terminal Hax-1 fragment functions as a dominant negative form of Hax-1, mediating mitochondrial

41 is dependent upon HIF-1 activity, because a dominant negative form of HIF-1alpha interferes with the

42 ely active form of IkappaK (IkappaKca), or a dominant negative form of IkappaK into the NAc.

43 s ILK inhibition, either by overexpressing a dominant negative form of ILK or by injecting an ILK ant

44 protein, which shows high similarity to the dominant negative form of integrin-linked kinase (ILK);

45 Expression of a dominant negative form of IRE1 alpha or XBP-1 significan

46 Ectopic expression of a dominant negative form of KLC1 resulted in the mislocali

47 formation and Wnt target gene expression; a dominant negative form of LRRFIP2 suppresses ectopic Wnt

48 amma-secretase inhibitors or by expressing a dominant negative form of mastermind-like 1 reduced thei

49 nterference RNA directed against MEKK3 and a dominant negative form of MEKK3 caused the reduction of

50 JNK inhibitor, SP600125, or expression of a dominant negative form of MKK4, a JNK upstream activator

51 By contrast, expression of a dominant negative form of Myc antagonizes self-renewal a

52 When Jurkat cells expressing a dominant negative form of NDE1 (NDE1-enhanced GFP fusion

53 ox4 short hairpin RNA (shRNA) or an inactive dominant negative form of Nox4 showed decreased ROS prod

54 ese drugs is eliminated in mice expressing a dominant negative form of NR4A and attenuated in mice wi

55 urther, transgenic tadpoles overexpressing a dominant negative form of p300, F-dnp300, containing onl

56 In transgenic mice that express a dominant negative form of p38 MAP kinase specifically in

57 chemical p38 inhibitor (SB202190) or with a dominant negative form of p38alpha, alleviates podocyte

58 R-flurbiprofen or ibuprofen treatment with a dominant negative form of p75(NTR) to antagonize p75(NTR

59 n vivo, we generated adenovirus containing a dominant negative form of p90RSK (Ad-DN-p90RSK).

60 embly of an ERAD complex, or expression of a dominant negative form of p97/VCP, a protein essential f

61 ell-intrinsic PD-1 blockade strategy using a dominant negative form of PD-1.

62 ucose concentrations and overexpression of a dominant negative form of PERK has no significant effect

63 An adenovirus expressing a dominant negative form of PI3K under control of the smoo

64 s inhibited by siRNA targeting PKCalpha or a dominant negative form of PKCalpha (PKCalpha DN).

65 PKD-1 by RNA interference or expression of a dominant negative form of PKD-1 did not have a significa

66 es transfected with an adenovirus encoding a dominant negative form of PPARalpha were resistant to th

67 ctivity by ERK5 activation was reversed by a dominant negative form of PPARdelta suggesting that ERK5

68 amma-secretase inhibitors, expression of the dominant negative form of PS1, and in PS1/PS2 knock-out

69 88-FVIIa in the REC, whereas expression of a dominant negative form of Rab11 led to accumulation of i

70 ed cell circularity, and overexpression of a dominant negative form of Rac reverses these morphologic

71 meant TRPM7 is suppressed by expression of a dominant negative form of Rac, as well as by Mg(2+) supp

72 tion is eliminated by expression of either a dominant negative form of RARalpha or a GATA-2 mutant th

73 Expression of a dominant negative form of Ras, an upstream activator of

74 transduction with a retrovirus expressing a dominant negative form of retinoic acid receptor type al

75 king tsc2+ is rescued by the expression of a dominant negative form of rhb1+, the Rheb homolog in S.

76 ivity of wild-type RUNX1 and functioned as a dominant negative form of RUNX1, resulting in enhanced s

77 case is further increased by expression of a dominant negative form of Slx1.

78 s the loss-of-Hh wing phenotype induced by a dominant negative form of Smoothened (Smo).

79 The dominant negative form of Sp1 abrogated the oxidative st

80 , we show that blocking Spry2 activity via a dominant negative form of Spry2 cooperates with c-Met to

81 e generated transgenic tadpoles expressing a dominant negative form of SRC3 (F-dnSRC3).

82 Microinjection of an mRNA encoding a dominant negative form of Suppressor of Hairless (dn-Su(

83 Transfection of these cells with a dominant negative form of TAK1 blocked arachidonic acid-

84 Ectopic expression of a dominant negative form of TCF4 inhibited hTERT expressio

85 tly induced MSX2 and ectopic expression of a dominant negative form of TCF4 inhibited MSX2 expression

86 or type II (dnTGFbetaRII) mice, expressing a dominant negative form of TGFbeta receptor II under cont

87 ve previously shown that overexpression of a dominant negative form of the cJun proto-oncogene, a cJu

88 induced by overexpression of Tsg101, Hrs, or dominant negative form of the class E VPS ATPase, VPS4.

89 of 20E from adult males by overexpressing a dominant negative form of the Ecdysone receptor (EcR) or

90 Here, we used a mouse expressing a truncated dominant negative form of the human TCF4 transcription f

91 sgene, GFAP-IkappaBalpha-dn, overexpresses a dominant negative form of the inhibitor of NF-kappaB (Ik

92 To address this, we generated an inducible dominant negative form of the IP(3)R (IP(3)R(DN)).

93 hibitor Y27632 and adenoviruses containing a dominant negative form of the rock gene were used to tre

94 owing limb were targeted for expression of a dominant negative form of the TH receptor by sperm-media

95 ncreases of transgenic tadpoles expressing a dominant negative form of the TH receptor controlled by

96 Expression of a dominant negative form of the thyroid hormone receptor (

97 genic Xenopus laevis tadpoles that express a dominant negative form of the thyroid hormone receptor (

98 By inducing a dominant negative form of the thyroid hormone receptor u

99 and because RAW-264 cells transfected with a dominant negative form of TLR4 responded normally to inf

100 , whereas CCND1 and ZNF703 cooperated with a dominant negative form of TP53.

101 ing and was suppressed by IkappaBalpha and a dominant negative form of TRAF6.

102 We have reported that mice expressing a dominant negative form of transforming growth factor bet

103 ratory has reported that mice that express a dominant negative form of transforming growth factor bet

104 ice with a T cell-restricted expression of a dominant negative form of transforming growth factor bet

105 Dominant negative form of transforming growth factor bet

106 at the SUMOylation defective mutant of ERK5, dominant negative form of Ubc9 (DN-Ubc9), and small inte

107 d ERK5-SUMOylation, and the K6R/K22R mutant, dominant negative form of Ubc9, and siRNA-PIAS1 reversed

108 ited by the proteasome inhibitor MG132 and a dominant negative form of ubiquitin, indicating that at

109 CREB and ATF-2, cells were transfected with dominant negative forms of ATF-2 or CREB.

110 In addition, dominant negative forms of ATR but not ATM were able to

111 EBP beta as we had previously observed using dominant negative forms of CREB.

112 essed during early feather morphogenesis and dominant negative forms of each receptor impair the epit

113 l activity was attenuated in the presence of dominant negative forms of either PI3K or protein kinase

114 ells that expressed constitutively active or dominant negative forms of factors in the Wnt or phospho

115 genetic approaches (such as point mutations, dominant negative forms of genes, and siRNAs against spe

116 When introduced into hepatocytes, both dominant negative forms of Mlx inhibited the glucose res

117 We constructed two different dominant negative forms of Mlx that could dimerize with

118 ese effects of lauric acid were inhibited by dominant negative forms of Nod1 or Nod2, but not by domi

119 Two dominant negative forms of RFX5 activate both collagen g

120 With the aid of specific inhibitors and dominant negative forms of signaling molecules, we deter

121 ate the role of BMP signalling by expressing dominant negative forms of Smad4 and Bmpr2, by downregul

122 However, transfection of astrocytes with dominant negative forms of the helicases implicated MDA-

123 ice overexpressing constitutively active and dominant negative forms of the p110alpha catalytic subun

124 (siRNA) to Rab5 or Rab7 and cells expressing dominant negative forms of these GTPases, suggesting ent

125 ed binding to the RGS4 promoter in vivo, and dominant negative forms of these proteins repressed RGS4

126 t negative forms of Nod1 or Nod2, but not by dominant negative forms of TLR2, TLR4, and TLR5.

127 models, transgenic expression of truncated (dominant negative) form of TGF-betaRII (dnTGFbetaRII) an

128 In contrast, a virus that overexpressed a dominant-negative form of a 4.1N C-terminal domain (HSV

129 By overexpressing a dominant-negative form of a Bmp receptor at various embr

130 known PI3K inhibitors, or by expression of a dominant-negative form of AKT promotes arterial specific

131 steoclastogenesis by RelB-induced Cot, and a dominant-negative form of Akt significantly inhibited it

132 n the activation of AMPK, as expression of a dominant-negative form of AMPK abolished this effect.

133 effect of ethanol, whereas coexpression of a dominant-negative form of AMPK augmented the effect.

134 Transduction with a dominant-negative form of AMPK reversed these effects, s

135 Inhibition of AP1 function with a dominant-negative form of AP1 also inhibited expression.

136 We show that in vivo, overexpression of the dominant-negative form of ARF6 rescues the neuronal migr

137 deficiency induced by genetic ablation or a dominant-negative form of Atf6alpha abolished TM stimula

138 of Bcr using Bcr small interfering RNA and a dominant-negative form of Bcr (DN-Bcr) reversed Ang II-m

139 in flies, we designed a transgene encoding a dominant-negative form of BEAF under GAL4 UAS control.

140 Further, we identified a dominant-negative form of BLV Rex.

141 molecular CDK5 inhibitors roscovitine and a dominant-negative form of CDK5.

142 y with recombinant lentiviruses expressing a dominant-negative form of CDK9 (HA-dnCDK9) in peripheral

143 on did not occur in glial cells expressing a dominant-negative form of cGMP-dependent protein kinase

144 tracellular cAMP levels, overexpression of a dominant-negative form of ChREBP, and small-interfering-

145 , and that blocking AP-1 by overexpressing a dominant-negative form of cJun (cJun-DN, TAM67) inhibits

146 e the inhibition of axon growth induced by a dominant-negative form of CLIM (DN-CLIM).

147 Repression of ptc in the presence of the dominant-negative form of Cos2 requires Su(fu), which is

148 escent protein (GFP)-tagged CREB or mCREB (a dominant-negative form of CREB) in the VTA and, using a

149 these events in vivo by delivering a potent dominant-negative form of CREB, known as A-CREB, to the

150 +) mice and CRE-lacZ/ENT1(-/-) mice) and the dominant-negative form of CREB, we found that reduced CR

151 nt on PKA, and was completely abrogated by a dominant-negative form of CREB.

152 F-1 activities by forced overexpression of a dominant-negative form of CREB.

153 Expression of a dominant-negative form of Cul1 in HEK cells demonstrated

154 Derlin-2 function by expression of either a dominant-negative form of Derlin-2 or a short hairpin RN

155 In this transgenic model, a dominant-negative form of DISC1 (DN-DISC1) is expressed

156 rose (0.4 m), or through the expression of a dominant-negative form of dynamin prevents PMA-induced G

157 RNA interference, but not overexpression of dominant-negative form of E2F, efficiently reduces endog

158 Moreover, expression of a dominant-negative form of E2F1 rescued cells from apopto

159 We used EH21, a dominant-negative form of Eps15 that is an essential com

160 ibitors PD98059 or U0216, or expression of a dominant-negative form of ERK1 blocked HIF-1 activation

161 ion of a recombinant adenovirus encoding the dominant-negative form of ERK2 effectively blocked riton

162 d by the use of transgenic mice expressing a dominant-negative form of Fas-associated death domain in

163 iapoptotic protein Bcl-2 and expression of a dominant-negative form of Fas-associated death domain le

164 A dominant-negative form of FIP2 lacking its N-terminal C2

165 e demonstrated that targeted expression of a dominant-negative form of FoxF inhibits cell migration b

166 bited in fu mutant clones or by expressing a dominant-negative form of Fu, and such inhibition is all

167 on of PLC-beta3 at least as effectively as a dominant-negative form of full-length PLC-beta3.

168 Finally, we demonstrate that a dominant-negative form of Fyn kinase mimics, whereas a c

169 tors of galectin-3 function (beta-lactose, a dominant-negative form of galectin-3, Gal-3C, and anti-g

170 cardiomyocytes or with myocytes expressing a dominant-negative form of GATA4 enhanced or reduced HUVE

171 ors or in vivo by retroviral expression of a dominant-negative form of GSK-3.

172 lobradine, and by adenoviral expression of a dominant-negative form of HCN2.

173 A dominant-negative form of heat shock protein (HSP)110 (H

174 metastasis, inhibition of HIF-1alpha with a dominant-negative form of HIF-1alpha or 2-methoxyestradi

175 In addition, we construct and test a dominant-negative form of hlh-12, a gene that encodes a

176 we present the X-ray crystal structures of a dominant-negative form of human Scp1 (D96N mutant) bound

177 ling pathway, by the induced expression of a dominant-negative form of IGF1 receptor (IGF1R) or speci

178 SGK-induced cell survival was abolished by a dominant-negative form of IkappaB kinase beta (IKKbeta,

179 NF-kappaB in cells stably transfected with a dominant-negative form of IkappaBalpha and concurrently

180 diminished in the lungs of mice expressing a dominant-negative form of IkappaBalpha in airway epithel

181 calizes with CRB3-CLPI during mitosis, and a dominant-negative form of importin beta-1 closely phenoc

182 Significantly, a dominant-negative form of importin beta1 shown previousl

183 se line (CNP/dnIRF-1) that overexpresses the dominant-negative form of IRF-1 (dnIRF1) specifically in

184 Finally, hypothalamic expression of a dominant-negative form of Irx3 reproduces the metabolic

185 Introduction of a dominant-negative form of JNK1 inhibited EPO-dependent p

186 s, either by overexpressing cilia GPCRs or a dominant-negative form of Kif3a, significantly impaired

187 t observed in neurons coexpressing ACIII and dominant-negative form of Kif3a.

188 this study we show that the expression of a dominant-negative form of Kuzbanian (dnKuz) leads to red

189 iously reported that the pan-Notch inhibitor dominant-negative form of Mastermind-like 1 (DNMAML) mar

190 during EAE, we used the pan-Notch inhibitor dominant-negative form of Mastermind-like 1 (DNMAML), as

191 Overexpression of a dominant-negative form of MBP20 led to leaf simplificati

192 n of Mdm2 expression and overexpression of a dominant-negative form of Mdm2.

193 nase (MEK), and transgenic mice expressing a dominant-negative form of MEK have established the impor

194 ns transfected with mutant forms of Ras or a dominant-negative form of MEK1 (mitogen-activated protei

195 Pak1, 2, and 3 in NIH3T3 cells expressing a dominant-negative form of merlin, NF2(BBA) (NIH3T3/NF2(B

196 In cells stably expressing a dominant-negative form of MID1, significantly elevated l

197 otein Kinase Kinase 4 (MKK4) and MKK5, and a dominant-negative form of Mitogen-Activated Protein Kina

198 )-murine PKRN167 (mPKRN167), which encodes a dominant-negative form of mouse double-stranded RNA (dsR

199 Moreover, both siRNA knockdown of MYC and a dominant-negative form of MYC, omomyc, induce differenti

200 A dominant-negative form of MyD88 (MyD88(DN)) decreased th

201 transcription of SM alpha-actin gene, and a dominant-negative form of myocardin or a short interferi

202 helpless CD8(+) T cells, and expression of a dominant-negative form of Nab2 in helped CD8(+) T cells

203 ype littermates or after overexpression of a dominant-negative form of Narp in the striatum.

204 Expression of s-Nix, a dominant-negative form of Nix, protects neuronal PC12 ce

205 In addition, overexpression of a dominant-negative form of p53 (R273H) completely suppres

206 p90 ribosomal S6 kinase (WT-p90RSK-Tg) and a dominant-negative form of p90RSK (DN-p90RSK-Tg).

207 Because a dominant-negative form of Par1b blocked TCR-induced MTOC

208 Shh-mediated patterning, but expression of a dominant-negative form of patched 2 (Ptch2) caused an ac

209 , in 'open-book' explants or by expressing a dominant-negative form of Patched-1, Ptch1(Delta loop2),

210 linositol 3-kinase (PI3K) or expression of a dominant-negative form of PI3K caused inhibition of airw

211 s of PKCepsilon by transient expression of a dominant-negative form of PKCepsilon and by PKCepsilon-s

212 ression, and this effect was reversed by the dominant-negative form of PKCzeta (Ad.DN-PKCzeta).

213 Furthermore, gene transfer of a dominant-negative form of PW1 into muscle tissue in vivo

214 Knockdown of Rab35 or expression of a dominant-negative form of Rab35 impaired N- and M-cadher

215 Inhibition of endocytosis, by means of a dominant-negative form of Rab5, blocks internalisation o

216 ll migration by AMP-directed expression of a dominant-negative form of Rac1 protein results in the ab

217 It is noteworthy that expression of the dominant-negative form of Rac1 reduced 2-AG-induced cell

218 We also found that expressing a dominant-negative form of RAD51 in combination with a ZF

219 The introduction of the dominant-negative form of RAGE lacking RAGE signalling t

220 In particular, overexpression of the dominant-negative form of RAGE targeted to microglia (DN

221 e of Ras in lens development by expressing a dominant-negative form of Ras (dn-Ras) in the lens of tr

222 ermore, the Ras inhibitors manumycin A and a dominant-negative form of Ras (RasN17) and the PI3-K inh

223 syl transferase inhibitor manumycin-A, and a dominant-negative form of Ras (RasN17) block the circadi

224 Using mice that express a dominant-negative form of Ras, we demonstrate that Ras-m

225 transgenic mice that ubiquitously express a dominant-negative form of Rent1/hUpf1, an essential tran

226 Expression of a dominant-negative form of REST in OPCs prevented the cel

227 The dominant-negative form of RhoA GTPase and treatment of t

228 utation of the conserved GDI motif creates a dominant-negative form of Sestrin that renders mTORC1 ac

229 ent, we used Cre/lox technology to express a dominant-negative form of ShcA (ShcFFF) in nestin-expres

230 Here we report that mice carrying a dominant-negative form of SynCAM1 specifically targeted

231 g of WNT/beta-catenin signaling by DKK1 or a dominant-negative form of TCF4 reversed MYF5 expression,

232 Overexpression of a dominant-negative form of TCP1, TCP1-SRDX, with a 12-ami

233 In mice with a dominant-negative form of TGF-beta receptor II and impai

234 ouse transgenic for directed expression of a dominant-negative form of TGF-beta receptor type II (dnT

235 A dominant-negative form of the Ciona FGF receptor suppres

236 n of wild-type PMNs with Deltap85 protein, a dominant-negative form of the class IA PI3K regulatory s

237 Drosophila inhibitor of apoptosis Diap1 or a dominant-negative form of the Dronc caspase, even when c

238 associated degradation (ERAD) pathway with a dominant-negative form of the ERAD core component, valos

239 Expression of erk5 short hairpin or a dominant-negative form of the ERK5 upstream activator, M

240 Bcl-xL messenger RNA in osteoclasts, while a dominant-negative form of the Ets-2 blocked the protecti

241 Expression of a dominant-negative form of the murine I kappa B alpha (mI

242 Expression of a truncated, dominant-negative form of the nucleoporin NUP214/CAN, De

243 n of Ape1 using siRNA or the expression of a dominant-negative form of the protein has been shown to

244 ion in the motor domain of Cos2 results in a dominant-negative form of the protein that derepresses d

245 A dominant-negative form of the retinoic acid receptor alp

246 ause when COPII assembly is inhibited with a dominant-negative form of the Sar1 GTPase, tER sites rem

247 ynthesis inhibitors or the expression of the dominant-negative form of the stress-activated protein/e

248 performed with marrow from mice expressing a dominant-negative form of the TGF-betaRII on CD11c-expre

249 blocking antibodies, or overexpression of a dominant-negative form of the TLR-4 signaling adaptor TR

250 romin-deficient (Nf1(-/-)) mice expressing a dominant-negative form of the tumor suppressor p53 (DNp5

251 c-jun terminal kinase and by expression of a dominant-negative form of this kinase.

252 d Su(H), because overexpression of DTX1 or a dominant-negative form of this protein inhibits Su(H)-me

253 ne region of the ectodomain that generated a dominant-negative form of TLR9.

254 When cells were transfected with the dominant-negative form of TonEBP (DN-TonEBP) there was s

255 Mice that express a dominant-negative form of transforming growth factor-bet

256 ession of luciferase together with Myc and a dominant-negative form of Trp53 revealed that GABAergic

257 tion; however, overexpression of a truncated dominant-negative form of vimentin resulted in a signifi

258 ced by overexpression of an ATPase-defective dominant-negative form of Vps4B (Vps4B(E235Q)).

259 ecapitulated in transgenic mice expressing a dominant-negative form of WT1 in Sertoli cells, demonstr

260 -1(-/-) CD8(+) T cells or cells expressing a dominant-negative form of XBP-1 showed a decreased propo

261 In this study, we report on a dominant-negative form of zebrafish Duox1 that is able t

262 Here we show that overexpression of dominant-negative forms of (DN) PTEN, RhoA or its kinase

263 The expression of dominant-negative forms of actin-regulating Rho-family G

264 RNAi knockdown or the targeted expression of dominant-negative forms of Ap or Chi in PDF-expressing n

265 ilized transgenic zebrafish that overexpress dominant-negative forms of Bmp or Fgf receptors followin

266 In contrast, the overexpression of dominant-negative forms of Cdc42 or Rac1 results in a dr

267 Co-expression of constitutively active and dominant-negative forms of Cdc42 or RhoA did not affect

268 f neurons with kinase-dead forms of PKCzeta, dominant-negative forms of Cdc42, or mutant forms of Par

269 clin-dependent kinases (CDKs), as well as by dominant-negative forms of CDK1 and CDK2 and the pan-CDK

270 s of the TH promoter; or by co-expression of dominant-negative forms of CREB.

271 th lowered neuronal Cul3 expression and when dominant-negative forms of Cul3 are transfected into hip

272 find that overexpression of dTsc1, dTsc2, or dominant-negative forms of dTOR or dS6K all cause lifesp

273 We find that two dominant-negative forms of dual leucine zipper kinase (D

274 rm and retrovirally transduced wild-type and dominant-negative forms of E-cadherin into these cells.

275 hat inactivation of total E2F/DP activity by dominant-negative forms of E2F or DP does not prevent ce

276 By analyzing transgenic fish expressing dominant-negative forms of either bone morphogenetic pro

277 Inhibition of this phosphorylation by dominant-negative forms of ERK or by treatment of cells

278 Moreover, the overexpression of dominant-negative forms of FoxG1 blocks the ability of I

279 an hepatoma cells, whereas expression of the dominant-negative forms of MLK3 suppresses cell death in

280 Expressing non-phosphorylatable dominant-negative forms of MSY2 inhibits the maturation-

281 In addition, overexpression of dominant-negative forms of MyD88 and Mal/TIRAP significa

282 However, the expression of dominant-negative forms of p38 MAPK activators MKK3 or M

283 by selective inhibitors or by expression of dominant-negative forms of PKD.

284 nvestigations using constitutively active or dominant-negative forms of Rab GTPases provided addition

285 ell expansion was inhibited by wortmannin or dominant-negative forms of Rac1 or Akt.

286 expressing wild-type, dominant-positive, and dominant-negative forms of RhoA in HEK (human embryonic

287 rat cortical neurons using overexpression of dominant-negative forms of several transcription factors

288 Misexpression of dominant-negative forms of Tbx5 results in limb truncati

289 using mutant adenoviruses and wild-type and dominant-negative forms of the p300 protein, we showed t

290 appaBalpha, an inhibitor of NF-kappaB, or by dominant-negative forms of the upstream activator Ikappa

291 Transient transfection of dominant-negative forms of TLR2 or TLR4 reduced IL-8 pro

292 Dominant-negative forms of TRAF2 and TRAF3 inhibited but

293 Our prior studies have shown that a mutant (dominant-negative) form of a rare but highly penetrant p

294 ]) or fibroblast growth factor (FGF) (with a dominant=negative form of FGF receptor 1 [FGF-R1DN]), re

295 Knockdown of Cbl, expression of its dominant negative forms, or expression of an epsin-1 mut

296 The function of PML is blocked by its dominant-negative form PML-retinoic acid receptor alpha

297 -specific disruption of pnr function using a dominant-negative form pnrEnR revealed a cardiac autonom

298 Interfering with RUNX proteins using a dominant negative form results in decreased Ncr1 express

299 forms that mediate Wnt signals and truncated dominant negative forms that limit Wnt signals and may f

300 onversely, inhibiting endogenous aPKC with a dominant-negative form that is restricted to the nucleus