ライフサイエンスコーパス: dopamine D1 receptor

1 a positive allosteric modulator (PAM) at the dopamine D1 receptor.

2 gets: c-SRC kinase, Smoothened receptor, and dopamine D1 receptor.

3 e focused upon the effects of activating the dopamine D1 receptor.

4 eases in response to stimulation of striatal dopamine D1 receptors.

5 gic neurons, and (2) excitation initiated by dopamine D1 receptors.

6 c cholinergic, adenosine A2, dopamine D2, or dopamine D1 receptors.

7 g affinity (Ki = 49.3 nM) and selectivity to dopamine D1 receptors.

8 highest binding affinity (Ki = 60.3 nM) for dopamine D1 receptors.

9 nd relapse, largely dependent on activity of dopamine D1 receptors.

10 uent activation of norepinephrine alpha2 and dopamine D1 receptors.

11 region-specific pharmacological blockade of dopamine D1-receptors.

12 down by RNAi lead to elevated cAMP levels in dopamine D1 receptor-activated neuroblastoma cells.

13 Deficiencies in dopamine D1 receptor activation are seen in Parkinson di

14 spinogenesis are dependent on mating-induced dopamine D1 receptor activation in the NAc.

15 We show that dopamine D1 receptor activation promotes and D2 receptor

16 ing that it reduces hyperthermia produced by dopamine D1 receptor activation.

17 nvolved increased TrkB surface expression by dopamine D1 receptor activation.

18 phosphorylation, whereas the effects of the dopamine D1 receptor agonist are blocked by genistein, a

19 lated RGCs, the application of dopamine or a dopamine D1 receptor agonist decreased voltage-activated

20 In the Fyn knockout mice, the dopamine D1 receptor agonist failed to induce subcellula

21 hr34 DARPP-32 and phospho-Ser845 GluR1 after dopamine D1 receptor agonist or forskolin stimulation.

22 d by treatment of neostriatal neurons with a dopamine D1 receptor agonist or with forskolin, consiste

23 e-treated and normal individuals, whilst the dopamine D1 receptor agonist SKF 38393 (30 mg/kg, i.p.)

24 st dose tested (18 nmol) of a mixture of the dopamine D1 receptor agonist SKF 38393 and the D2 agonis

25 owing by conditioning rats under the partial dopamine D1 receptor agonist SKF 38393 or the opioid ant

26 e administration of a low dose of either the dopamine D1 receptor agonist SKF-38393 or the D2 recepto

27 The dopamine D1 receptor agonist SKF-82958 produces (1) an i

28 ain slices of neonatal (P7) rat striatum the dopamine D1 receptor agonist SKF-82958 significantly dec

29 Dopamine D1 receptor agonist treatment does not change t

30 acute behavioral response of DA-/- mice to a dopamine D1 receptor agonist was correlated with c-fos i

31 also attenuated the hyperthermia caused by a dopamine D1 receptor agonist, SKF 38393 (10 mg/kg, s.c.)

32 82958 (SKF), a previously characterized full dopamine D1 receptor agonist, to stimulate the transcrip

33 The selective dopamine D1 receptor agonists SKF 38393 (10 microM) and

34 This protocol has allowed the synthesis of a dopamine D1 receptor allosteric modulator without recour

35 harmacological roles of Gs- and Golf-coupled dopamine D1 receptor and adenosine A2A receptor in the b

36 an be used to reveal potentially therapeutic dopamine D1 receptor and adenosine A2A receptor ligands

37 ave been developed for 48 antagonists of the dopamine D1 receptor and applied to mining chemical data

38 We studied the dopamine D1 receptor and cocaine self-administration in

39 Simultaneous activation of dopamine D1 receptors and CPARs induced additive increas

40 This upregulation of NMDAR activity by dopamine D1 receptors and the previous finding on up-reg

41 brain and bound putative GLP-1 receptors on dopamine D1 receptor- and dopamine D2 receptor-expressin

42 These data reveal a rapid dopamine D1 receptor- and tyrosine kinase-dependent traf

43 It is interesting that dopamine D1 receptor antagonism counteracted the stimula

44 252a, a Trk tyrosine kinase inhibitor, and a dopamine D1 receptor antagonist could block the effects

45 Systemic administration of the selective dopamine D1 receptor antagonist SCH 23390 [R(+)-7-chloro

46 The dopamine D1 receptor antagonist SCH 23390 was ineffectiv

47 usion of 10 microg (but not 2 microg) of the dopamine D1 receptor antagonist SCH-23390 greatly impair

48 Pretreatment with the dopamine D1 receptor antagonist SCH23390 (0.1mg/kg, ip)

49 s sufficient to induce BDNF in the mPFC, and dopamine D1 receptor antagonist treatment blocked the an

50 way were attenuated by pretreatment with the dopamine D1 receptor antagonist, SCH23390, which also ca

51 kDa), in the absence or in the presence of a dopamine D1 receptor antagonist, we provide evidence tha

52 eceptors, and these effects are reduced by a dopamine D1 receptor antagonist.

53 eversed in the presence of 4 mum SCH23390, a dopamine D1 receptor antagonist.

54 sion of the AMPA-receptor antagonist CNQX or dopamine D1-receptor antagonist SCH-23390 into the DLS b

55 a CPP for cocaine that was not blocked by a dopamine D1-receptor antagonist.

56 Dopamine D1 receptor antagonists (SCH23390 and SKF83566)

57 Previous studies have shown that dopamine D1 receptors are preferentially expressed in st

58 In conclusion, neurokinin-1 and dopamine D1 receptors are required for the METH-induced

59 Blockade of dopamine D1 receptors attenuated prolonged wakefulness a

60 Importantly, systemic inhibition of dopamine D1 receptors attenuated the stroke-induced incr

61 Increased dopamine D1 receptor binding was found in the nucleus ac

62 riments (Daun02 lesioning of vmPFC and acute dopamine D1-receptor blockade with SCH39166 in NAc core

63 and full intrinsic activity at cloned human dopamine D1 receptors but had much lower affinity at dop

64 tive stimulus depended on NAcC AMPA/NMDA and dopamine D1 receptors, but the retrieval of the response

65 One new receptor, DAMB, was identified as a dopamine D1 receptor by sequence analysis and pharmacolo

66 and the previous finding on up-regulation of dopamine D1 receptors by NMDAR activation provide a cell

67 Stimulation of dopamine D1-receptors by SKF 82958 increased extracellul

68 ecause of increased transmission through the dopamine D1 receptor/cAMP-dependent protein kinase pathw

69 These results indicate that stimulation of dopamine D1 receptors can be coupled to the neurotrophin

70 In particular, direct pathway (dopamine D1 receptor-containing; D1R-) spiny projection

71 They also demonstrate that activation of dopamine D1 receptors corrects these deficits, through a

72 firing, and that this effect is mediated by dopamine D1 receptor-coupled Ca2+ signalling pathways.

73 rebral cortical areas, substantially reduced dopamine D1 receptor coupling to G(s)-protein, and defic

74 Dopamine D1 receptor (D1)-expressing neurons and D2-neur

75 inhibit movement, whereas those that express dopamine D1 receptors (D1+) project to the substantia ni

76 , we demonstrate for the first time that the dopamine D1 receptor (D1DR), the primary mediator of dop

77 Given the abundance of dopamine D1-receptors (D1DR), and its importance for mod

78 ccumbens are differentiated by expression of dopamine D1 receptors (D1DRs) or D2DRs, activation of wh

79 In this study, we show that mice lacking the dopamine D1 receptor (D1R KO mice) manifest greatly redu

80 ss impairs working memory via high levels of dopamine D1 receptor (D1R) activation of cyclic adenosin

81 82) in the CA1 region of the hippocampus via dopamine D1 receptor (D1R) activation, a process largely

82 disease, is associated with an alteration in dopamine D1 receptor (D1R) and glutamate receptor intera

83 y systemic pretreatment of CRF receptor 1 or dopamine D1 receptor (D1R) antagonist and augmented by c

84 A dopamine D1 receptor (D1R) antagonist blocked ghrelin-in

85 onvolute the process of signal bias from the dopamine D1 receptor (D1R) by exploring factors that pro

86 inding activity of agonist and antagonist of dopamine D1 receptor (D1R) by using quartz crystal micro

87 The dopamine D1 receptor (D1R) facilitates reward acquisitio

88 ological studies have clarified the roles of dopamine D1 receptor (D1R) in the medial prefrontal cort

89 The dopamine D1 receptor (D1R) in the nucleus accumbens (Acb

90 Dopamine D1 receptor (D1R) is an important drug target i

91 omato BAC transgenic mice and found that the dopamine D1 receptor (D1R) is expressed in retinal bipol

92 ntrol of genetic regulatory elements for the dopamine D1 receptor (D1R) or dopamine D2 receptor (D2R)

93 rrent synaptic activity and was reduced by a dopamine D1 receptor (D1R) protein kinase A pathway.

94 r casein kinase 2 (CK2) in the modulation of dopamine D1 receptor (D1R) signaling in cells.

95 , removing NMDARs from MSNs that express the dopamine D1 receptor (D1R) significantly attenuated AMPH

96 Here, we show the role of dopamine D1 receptor (D1R)-expressing cardiomyocytes (CM

97 Finally, conditional knock-out of Cav1.2 in dopamine D1 receptor (D1R)-expressing cells resulted in

98 Here we isolated a population of dopamine D1 receptor (D1R)-expressing neurons within the

99 the activity of striatal neurons expressing dopamine D1 receptor (D1R).

100 The role of dopamine D1 receptors (D1R) and D2 receptors (D2R) in th

101 cently found that microglial phagocytosis of dopamine D1 receptors (D1R) in the nucleus accumbens (NA

102 gh both angiotensin AT1 receptors (AT1R) and dopamine D1 receptors (D1R) modulates renal sodium excre

103 n cortical dopamine, and possible changes in dopamine D1 receptors (D1R).

104 ly in medium spiny neurons (MSNs) expressing dopamine D1 receptors (D1R).

105 mory, and Ca(v)1.2 is a downstream target of dopamine D1-receptor (D1R) signaling, we next generated

106 rt of this, increased activation of striatal dopamine-D1 receptors (D1R) results in desensitization o

107 This modulation is mainly mediated by dopamine D1 receptors (D1Rs) and D2Rs, which are highly

108 ippocampal neurons, we demonstrate here that dopamine D1 receptors (D1Rs) and NMDARs form dynamic sur

109 However, while dopamine D1 receptors (D1Rs) in the prefrontal cortex (P

110 quantify the effect of D3R overexpression on dopamine D1 receptors (D1Rs) in the striatum.

111 are medium spiny neurons (MSNs) that express dopamine D1 receptors (D1Rs) or D2 receptors (D2Rs), whi

112 Blocking dopamine D1 receptors (D1Rs) or inhibiting novelty-tagge

113 The dopamine D1 receptor-D3 receptor (D1R-D3R) heteromer is

114 Changes in opioid and dopamine D1 receptor densities were more subtle and infl

115 mygdala enhanced cue-reward learning through dopamine D1 receptor-dependent mechanisms and suppressed

116 neurons of the PFC, which are regulated by a dopamine D1 receptor-dependent pathway.

117 Here, we describe for the first time a dopamine D1 receptor-dependent quinone reductase 2 pathw

118 An amphetamine challenge reversed CPD via a dopamine D1-receptor-dependent paradoxical presynaptic p

119 Intra-basolateral amygdala antagonism of dopamine D1-receptors did not prevent the reacquisition

120 dient predicted episodic memory and mirrored dopamine D1 receptor distribution, capturing shared func

121 SRT in the rat using direct infusions of the dopamine D1 receptor (DRD1) antagonist SCH 23390 or dopa

122 ctron microscopy (cryo-EM) structures of the dopamine D1 receptor (DRD1) coupled to Gs heterotrimer i

123 with a single nucleotide polymorphism in the dopamine D1 receptor (DRD1) gene, which was associated w

124 Cells expressing the dopamine D1 receptor (DRD1) have significant functional

125 contrast, decreased dysbindin did not change dopamine D1 receptor (DRD1) levels, or its basal or dopa

126 Furthermore, this LTP is more prominent in dopamine D1 receptor-expressing (D1) MSNs than D2 MSNs a

127 cortical-limbic induced compulsions in which dopamine D1 receptor-expressing (D1+) neurons in restric

128 cholera toxin (CT) transgene in a subset of dopamine D1 receptor-expressing (D1+) neurons thought to

129 idence that supports a role of Cav1.2 within dopamine D1 receptor-expressing cells of the hippocampus

130 he nucleus accumbens, more specifically, the dopamine D1 receptor-expressing medium spiny neurons (D1

131 own to inhibit glutamatergic transmission in dopamine D1 receptor-expressing medium spiny neurons (D1

132 e the inhibitory function of PSAM(4)-GlyR in dopamine D1 receptor-expressing medium spiny neurons (D1

133 ene expression and muscarinic M4 receptor in dopamine D1 receptor-expressing medium spiny neurons.

134 We also found that HDAC5 functions within dopamine D1 receptor-expressing MSNs to suppress cue-ind

135 ent of excitatory synaptic transmission onto dopamine D1 receptor-expressing neurons (D1+ neurons) in

136 uced PGE2 targeted EP1 receptors on striatal dopamine D1 receptor-expressing neurons and that this si

137 IGNIFICANCE STATEMENT ERK phosphorylation in dopamine D1 receptor-expressing neurons exerts a pivotal

138 ndicate that NCS-Rapgef2 signaling to ERK in dopamine D1 receptor-expressing neurons in the NAc, but

139 ignaling to ERK that underlies plasticity in dopamine D1 receptor-expressing neurons leading to acqui

140 Furthermore, the activity of dopamine D1 receptor-expressing neurons promoted threat

141 in TS not only potentiated the responses of dopamine D1 receptor-expressing neurons to novel sensory

142 diacylglycerol lipase alpha (DGLalpha), from dopamine D1 receptor-expressing or adenosine A2a recepto

143 insic or synaptic properties on thin-tufted, dopamine D1-receptor-expressing ACC L5 PyNs recorded fro

144 ned mice that lack M4 mAChRs specifically in dopamine D1-receptor-expressing neurons, suggesting that

145 duced hypothyroidismin hamsters (HH) altered dopamine D1 receptor expression, D1 receptor-modulated v

146 R and beta2-AR), muscarinic (M1 and M2), and dopamine (D1) receptor families.

147 in humans, the specific contribution of the dopamine D1 receptor family to these behaviors remained

148 In this scheme, activation of dopamine D1 receptors following light exposure triggers

149 f dendritic spines in MSN-D1 (MSN-expressing dopamine D1 receptors) from the core and shell of nucleu

150 The stability of states relates to dopamine D1 receptor gene expression while state transit

151 f catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due

152 Stimulation of dopamine D1 receptors has profound effects on addictive

153 ined the regulation of NMDAR currents by the dopamine D1 receptor in PFC pyramidal neurons.

154 We recently reported that dopamine D1 receptor in the medial prefrontal cortex (mP

155 areas, among which the IPAC is regulated by dopamine D1 receptor in the mPFC perhaps through direct

156 PK and JNK signaling pathways is mediated by dopamine D1 receptors in SK-N-MC neuroblastoma cells.

157 Here, we demonstrate that dopamine D1 receptors in the dentate gyrus act as a pivo

158 While dopamine D1 receptors in the striatum are required for a

159 We recently demonstrated that dopamine D1 receptors in the ventral tegmental area (VTA

160 d by testing the hypothesis that blockade of dopamine D1 receptors in the VTA attenuates the rewardin

161 rable evidence suggests an important role of dopamine D1 receptors in these effects.

162 Dopamine D1 receptors, in contrast, stimulate GluA1 extr

163 The dopamine D1 receptor is involved in mediating cocaine-in

164 t the direct inhibition of NMDA receptors by dopamine D1 receptor ligands is due to the channel pore

165 dies and structure-activity relationships of dopamine D1 receptor ligands suggest that their intrinsi

166 tina that bright-light-induced activation of dopamine D1 receptors located on ON-center cone bipolar

167 Here we show that dopamine D1 receptors mediate prefrontal control of sign

168 The dopamine D1 receptor-mediated NMDA receptor trafficking

169 deletion of any other NF subunit, amplifies dopamine D1-receptor-mediated motor responses to cocaine

170 rats that express Cre recombinase in either dopamine D1 receptor- or adenosine 2a (A2a) receptor-exp

171 Multiple proteins of NMDA receptor and dopamine D1 receptor pathways are being regulated in way

172 Dopamine D1 receptors play an important role in movement

173 To determine whether the dopamine D1 receptor plays a crucial role in the behavio

174 What is known is that the dopamine D1 receptor plays an important role.

175 ently completed clinical studies suggest the dopamine D1 receptor positive allosteric modulator (PAM)

176 At low cortical frequencies, dopamine D1 receptors promote glutamate release to both

177 y delays healing, whereas the stimulation of dopamine D1 receptors promotes angiogenesis and expedite

178 ing an amine-accepting binding domain on the dopamine D1 receptor protein that may be further explore

179 e, the PDE10A radioligand (18)F-MNI-659, the dopamine D1 receptor radioligand (11)C-NNC 112, and the

180 e, the PDE10A radioligand (18)F-MNI-659, the dopamine D1 receptor radioligand (11)C-NNC 112, and the

181 The dopamine D1 receptor, responsible for protein kinase A a

182 twork firing, whereas optimal stimulation of dopamine D1 receptors sculpts network inputs to refine m

183 STDP in MSNs expressing dopamine D1 receptors shifted from spike-timing-dependen

184 Both protein kinase A and dopamine D1 receptor signaling are required for the func

185 Several lines of evidence suggest that dopamine D1 receptor signaling enhances dendritic excita

186 alk between PKA and ERK1/2 with relevance to dopamine D1 receptor signaling in striatal neurons.

187 ntidepressant-like effects of stress-induced dopamine D1 receptor signaling in the mPFC.

188 Although considerable evidence implicates dopamine D1-receptor signaling in the nucleus accumbens

189 In rodents, dopamine D1 receptor stimulation causes a complex behavi

190 FosB and dynorphin-B expression mediated by dopamine D1 receptor stimulation in the development of 3

191 onal state of progestin receptors because of dopamine D1 receptor stimulation, facilitation of lordos

192 (SDS) in mice, here we identified a role of dopamine D1 receptor subtype in mPFC excitatory neurons

193 It is generally assumed that the coupling of dopamine D1 receptors to adenylyl cyclase is mediated by

194 Mice that incorporate the dopamine D1 receptor transgene controlled by the D1 rece

195 e previously reported that activation of the dopamine D1 receptor triggers a rapid redistribution of

196 neurotensin (NTR1), adrenergic (beta1), and dopamine (D1) receptors were treated with fluorescently

197 three positive allosteric modulators of the dopamine D1 receptor were found to bind to distinct and

198 However, this effect diminished when the dopamine D1 receptors were pharmacologically blocked.

199 CPARs and dopamine D1 receptors were required in vivo for elevated

200 We also show that a mutant dopamine D1 receptor, which has likewise been described

201 (GBC) in association with regional levels of dopamine D1 receptors, which are critical for drug rewar

202 NR2A, and NR2B was normal, and activation of dopamine D1 receptors with the agonist SKF-82958 [(+/-)-

203 sensitizing GABAergic input is controlled by dopamine D1 receptors, with horizontal cells serving as

204 lag in phosphorylation of a peptide from the dopamine D1 receptor without ATP preincubation.