ライフサイエンスコーパス: dopamine D2 receptor

1 and [C-11]raclopride (a radioligand for the dopamine D2 receptor).

2 s also transactivated by and associated with dopamine D2 receptor.

3 ntipsychotic drugs were thought to block the dopamine D2 receptor.

4 TM4) as a symmetrical dimer interface in the dopamine D2 receptor.

5 gh stimulation of the 5-HT1A receptor or the dopamine D2 receptor.

6 water-accessible binding-site crevice in the dopamine D2 receptor.

7 o acts at other receptor sites including the dopamine D2 receptor.

8 ding protein that modulates signaling by the dopamine D2 receptor.

9 PS) due to their rapid dissociation from the dopamine D2 receptor.

10 binding affinities to serotonin 5-HT(2A) and dopamine D2 receptors.

11 imaging assessments and in vitro measures of dopamine D2 receptors.

12 ed by SCAM studies of TMH6 in the opioid and dopamine D2 receptors.

13 mate receptors (mGluRs), phospholipase C, or dopamine D2 receptors.

14 ls but also was bidirectionally modulated by dopamine D2 receptors.

15 an embryonic kidney tsA-201 cells along with dopamine D2 receptors.

16 n drug-addicted subjects is a lower level of dopamine D2 receptors.

17 ive blockade of nigrostriatal and mesolimbic dopamine D2 receptors.

18 c effects mainly by acting as antagonists at dopamine D2 receptors.

19 sing pituitary tumor cells stably expressing dopamine D2 receptors.

20 ion tomography and [11C]raclopride to assess dopamine D2 receptors.

21 tly reduced affinity for 5-HT1A, 5-HT2C, and dopamine D2 receptors.

22 ty predominantly through actions at striatal dopamine D2 receptors.

23 localized on the same neurons as Gi-coupled dopamine D2 receptors.

24 f basal ganglia neuronal circuits containing dopamine D2 receptors.

25 quires an optimal dose that blocks the brain dopamine D2 receptors.

26 ite of initial action is through blockade of dopamine D2 receptors.

27 ture-functional selectivity relationships at dopamine D2 receptors.

28 erably Go) over beta-arrestin recruitment at dopamine D2 receptors.

29 milarities to that effected by activation of dopamine D2 receptors.

30 graphy (PET), a radiotracer for the striatal dopamine D2 receptor ([11C]raclopride), and a pharmacolo

31 s ([(3)H]prazosin, IC(50) = 0.54 microM) and dopamine D2 receptors ([(3)H]raclopride, IC(50) = 1.2 mi

32 Chronic blockade of dopamine D2 receptors, a common mechanism of action for

33 th Drd1a-Cre BAC transgenic mice rescued the dopamine D2 receptor abnormality and multiple behavioral

34 ease in cytosolic [Ca2+] ([Ca2+]i) caused by dopamine (D2) receptor activation and the calcium depend

35 nuate cocaine-induced hyperthermia, and that dopamine D2 receptor activation plays a permissive role

36 ng-term depression (eCB-LTD), which requires dopamine D2 receptor activation.

37 Increased striatal dopamine D2 receptor activity is thought to contribute t

38 Pharmacological manipulation of dopamine D2 receptor activity using the agonist cabergol

39 A/2B receptors versus alpha-1 adrenergic and dopamine D2 receptor affinity.

40 Quinpirole, a dopamine (D2) receptor agonist, reduced [Ca2+]i by 55 +/

41 ing molecules, incorporating ropinirole as a dopamine D2 receptor agonist and ZM 241385 as an adenosi

42 We observed that the dopamine D2 receptor agonist bromocriptine improved the

43 PKC activation by either phorbol ester or a dopamine D2 receptor agonist caused the movement of RACK

44 ntified recently as a functionally selective dopamine D2 receptor agonist contributing potentially to

45 The dopamine D2 receptor agonist quinpirole, but not the D1

46 lactin occurred with systemic cabergoline, a dopamine D2 receptor agonist, blocked priming selectivel

47 on firing by pretreatment with quinpirole, a dopamine D2-receptor agonist, blocked both cocaine- and

48 by administering its precursor l-DOPA and/or dopamine D2-receptor agonists.

49 pparent bias of a series of agonists for the dopamine D2 receptor and can even lead to reversals in t

50 (iii) the transcriptional activation of the dopamine D2 receptor and numerous schizophrenia candidat

51 k of schizophrenia are the gene encoding the dopamine D2 receptor and those involved in the upstream

52 The association between level of dopamine D2 receptors and metabolism in the orbitofronta

53 he major antipsychotic drugs act by blocking dopamine D2 receptors and that dopamine-releasing drugs

54 11C]raclopride to assess the availability of dopamine D2 receptors and with [18F]fluorodeoxyglucose t

55 ceptors, voltage-gated calcium channels, the dopamine D2 receptor, and complement glycoproteins.

56 disease studies converge to suggest that the dopamine D2 receptor, and shifts in the cortical excitat

57 These results suggest dopamine D2 receptor antagonism holds promise as a poten

58 nist activity (S2 group) or with predominant dopamine D2 receptor antagonist activity (D2 group; HBBM

59 ly, pharmacologic PRL mobilization using the dopamine D2 receptor antagonist domperidone prevented HC

60 earning, social learning is modulated by the dopamine D2 receptor antagonist haloperidol when social

61 halothane anaesthesia) administration of the dopamine D2 receptor antagonist haloperidol, but not rac

62 ment with the typical antipsychotic drug and dopamine D2 receptor antagonist haloperidol.

63 Systemic administration of a selective dopamine D2 receptor antagonist partially blocked the ef

64 Pretreatment with the dopamine D2 receptor antagonist raclopride (1mg/kg, ip)

65 tate, challenging them with the preferential dopamine D2 receptor antagonist raclopride and D1 recept

66 ndicated by their altered sensitivity to the dopamine D2 receptor antagonist raclopride.

67 The dopamine D2 receptor antagonist, raclopride, attenuated

68 or antagonist, SR141716A (5 mg/kg, i.p.), or dopamine D2 receptor antagonist, S(-)-raclopride (5 mg/k

69 ging agent of breast cancer, and (-)-IBZM, a dopamine D2 receptor antagonist.

70 The dopamine D2-receptor antagonist sulpiride decreases spon

71 Dopamine (D2) receptor antagonists were evaluated (Halop

72 These included four dopamine D2 receptor antagonists, with D2 receptors havi

73 results show that the splice variants of the dopamine D2 receptor are differentially distributed and

74 Dopamine D2 receptors are involved with wakefulness, but

75 y transfer to demonstrate that at least four dopamine D2 receptors are located in close molecular pro

76 These results suggest that dopamine D2 receptors are strategically positioned for p

77 yramine binds with a similar affinity to the dopamine D2 receptor as hordenine (K(i) 31.3 uM) showing

78 were no significant differences in baseline dopamine D2 receptor availability between the Parkinson'

79 Lower levels of dopamine D2 receptor availability have been previously r

80 ood intake, and obese persons have decreased dopamine D2 receptor availability in the striatum.

81 ine release was assessed by the reduction in dopamine D2 receptor availability induced by an acute am

82 s used in 12 rhesus macaques to determine if dopamine D2 receptor availability was associated with th

83 Dopamine D2 receptor availability was measured with [11C

84 Brain dopamine D2 receptor availability was measured with posi

85 Striatal dopamine D2 receptor availability was significantly lowe

86 ated by the amphetamine-induced reduction in dopamine D2 receptor availability, measured as the bindi

87 cerebellum minus 1) was used as a measure of dopamine D2 receptor availability.

88 performance were monitored using a marker of dopamine D2-receptor availability (11)C-raclopride (RAC)

89 otency while reducing alpha-1 adrenergic and dopamine D2 receptor binding affinities substantially, r

90 to assess the relationship between striatal dopamine D2 receptor binding, trinucleotide repeat numbe

91 e disease predominantly uses one mechanism - dopamine D2 receptor blockade - but often shows limited

92 Dopamine D2 receptor blockade has been an obligate mecha

93 tion attenuates the export of beta(2)-AR and dopamine D2 receptor but not of epidermal growth factor

94 The R isomer did not directly stimulate the dopamine D2 receptor but potentiated the effects of dopa

95 l compound, SEP-363856, that does not act on dopamine D2 receptors but has agonist activity at trace

96 in COS-7 cells or activation of co-expressed dopamine (D2) receptors by quinpirole (100 nM) in oocyte

97 3H]spiroperidol/N-propylnorapomorphine (NPA) dopamine D2 receptor competitive binding assay, 3 and 4,

98 Dopamine D2 receptors contain a cluster of serine residu

99 Overexpression of p11 in dopamine D2 receptor-containing LHb neurons of control m

100 -deficient mice to directly evaluate whether dopamine D2 receptors contribute to alcohol (ethanol) co

101 sly that neural responses to ethanol and the dopamine D2 receptor (D2) agonist 2,10,11-trihydroxy-N-p

102 The dopamine D2 receptor (D2) system has been implicated in

103 ces: fibroblast growth factor (FGF2) and the dopamine D2 receptor (D2).

104 Here we determine the role of dopamine D2 receptors (D2) in PKA signaling responses to

105 Those that express dopamine D2 receptors (D2+) project to the globus pallid

106 lasticity in medium spiny neurons expressing dopamine D2 receptors (D2-MSNs) in the nucleus accumbens

107 n NAc medium spiny neurons (MSNs) expressing dopamine D2 receptors (D2-MSNs), with opposite regulatio

108 d excitation, and physiological responses to dopamine D2-receptor (D2) autoinhibition.

109 nce support a role for an involvement of the dopamine D2-receptor (D2-R) in the pathophysiology of sc

110 Par-4 directly interacts with the dopamine D2 receptor (D2DR) via the calmodulin binding m

111 ve previously described a phenomenon whereby dopamine D2 receptor (D2R) activation elicits afterdepol

112 Aberrant dopamine D2 receptor (D2R) activity is associated with n

113 ines and heteroarylhomopiperazines with high dopamine D2 receptor (D2R) affinity.

114 tation of cholinergic interneurons (ChIs) by dopamine D2 receptor (D2R) agonism using ex vivo slice e

115 Intra-BLA infusions of the dopamine D2 receptor (D2R) agonist quinpirole decreased

116 y 40% increase in membrane expression of the dopamine D2 receptor (D2R) and a twofold increase in D2R

117 te signaling by mu-opioid receptor (MOR) and dopamine D2 receptor (D2R) and are implicated in drug ad

118 ormance, more recent studies have shown that dopamine D2 receptor (D2R) antagonism, paired with a mot

119 ale and female rats received injections of a dopamine D2 receptor (D2R) antagonist (eticlopride), D2R

120 udy, we found that prochlorperazine (PCZ), a dopamine D2 receptor (D2R) antagonist approved to treat

121 eased mu-opioid receptor (MOR) and decreased dopamine D2 receptor (D2R) availability in addictive dis

122 caine abuse in humans is associated with low dopamine D2 receptor (D2R) availability in the striatum.

123 ders are associated with diminished striatal dopamine D2 receptor (D2R) availability, likely reflecti

124 Altered dopamine D2 receptor (D2R) binding in the striatum has b

125 A decrease in dopamine D2 receptor (D2R) binding in the striatum is on

126 mitigates aberrant motor learning induced by dopamine D2 receptor (D2R) blockade in mice.

127 st-in-class beta-arrestin-biased agonists of dopamine D2 receptor (D2R) by extensively exploring mult

128 Evidence indicating an increase in dopamine D2 receptor (D2R) density and occupancy in pati

129 that SB269652 (1) engages one protomer of a dopamine D2 receptor (D2R) dimer in a bitopic mode to al

130 ) adopts a bitopic pose at one protomer of a dopamine D2 receptor (D2R) dimer to negatively modulate

131 ation, with validation in GPCR structure and dopamine D2 receptor (D2R) function.

132 ature of MCs is the promoter activity of the dopamine D2 receptor (D2R) gene (Drd2), and previous wor

133 The dopamine D2 receptor (D2R) has received much attention i

134 Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromers are key modulators

135 d in mice with cell-specific ablation of the dopamine D2 receptor (D2R) in the striatal medium spiny

136 wed augmented binding of radioligands to the dopamine D2 receptor (D2R) in the striatum as well as ne

137 The dopamine D2 receptor (D2R) is a G protein-coupled recept

138 The dopamine D2 receptor (D2R) is a G protein-coupled recept

139 The dopamine D2 receptor (D2R) is a major component of the d

140 henotype is supported by decreased available dopamine D2 receptor (D2R) levels and the failure of ant

141 es have suggested that biased agonism at the dopamine D2 receptor (D2R) may be advantageous for the t

142 The dopamine D2 receptor (D2R) mediates ligand-biased signal

143 Striatal dopamine D2 receptor (D2R) relies upon G protein- and be

144 Inhibitory signaling at somatodendritic dopamine D2 receptor (D2R) synapses modulates excitabili

145 DA-approved medications target primarily the dopamine D2 receptor (D2R) to inhibit G(i/o)-mediated ad

146 neuromodulator dopamine signals through the dopamine D2 receptor (D2R) to modulate central nervous s

147 selective for the dopamine D3 receptor over dopamine D2 receptor (D2R), despite high sequence identi

148 The dopamine D2 receptor (D2R), like many G-protein-coupled

149 h both the G-protein-coupled receptor (GPCR) dopamine D2 receptor (D2R), regulating its internalizati

150 cid (DHA), potentiates ligand binding to the dopamine D2 receptor (D2R), suggesting that DHA acts as

151 se hamster ovary cell lines that express the dopamine D2 receptor (D2R), we show here that the D2R ag

152 We hypothesized that striatopallidal dopamine D2 receptor (D2R)-expressing neurons promote av

153 are highly influenced by cannabinoids and by dopamine D2 receptor (D2R)-mediated regulation of fast-f

154 gh sequence homology between the D3R and the dopamine D2 receptor (D2R).

155 a) in Tg sera were found to react with human dopamine D2 receptor (D2R).

156 ements for the dopamine D1 receptor (D1R) or dopamine D2 receptor (D2R).

157 energic receptor (beta2AR) or the Gi-coupled dopamine D2 receptor (D2R).

158 rapeutic advantages to ligands targeting the dopamine D2 receptor (D2R).

159 s a heteroreceptor complex formation between dopamine D2 receptors (D2R) and NMDA receptor NR2B subun

160 Drugs acting at dopamine D2 receptors (D2R) are commonly used to allevia

161 Dopamine D2 receptors (D2R) are G protein-coupled recept

162 Striatal dopamine D2 receptors (D2R) are major regulators of moto

163 ly available antipsychotic drugs (APDs) bind dopamine D2 receptors (D2R) at therapeutic concentration

164 In mammals, neurons expressing dopamine D2 receptors (D2R) in the dorsal striatum (DS)

165 is study, we found that CaMKIIalpha binds to dopamine D2 receptors (D2R) in vitro.

166 Blocking dopamine D2-receptors (D2R) altered generalization behav

167 Striatal dopamine D2 receptors (D2Rs) are important for motor out

168 Because dopamine D2 receptors (D2Rs) are involved in spatial cog

169 of the fact that in deep layers of the mPFC, dopamine D2 receptors (D2Rs) are mainly expressed by SC

170 p recordings, we demonstrate that cerebellar dopamine D2 receptors (D2Rs) in mice are preferentially

171 been ascribed to D2Rs.SIGNIFICANCE STATEMENT Dopamine D2 receptors (D2Rs) in the prefrontal cortex (P

172 Activation of axonal dopamine D2 receptors (D2Rs) increases action potential

173 Dopamine D2 receptors (D2Rs) play a major role in the fu

174 Presynaptic dopamine D2 receptors (D2Rs) regulate dopamine transport

175 Dopamine D2 receptors (D2Rs) suppress lateral inhibition

176 Striatal dopamine D2 receptors (D2Rs) were downregulated in obese

177 l ganglia of adult mice that is regulated by dopamine D2 receptors (D2Rs).

178 ng lactotroph cells by activating lactotroph dopamine D2 receptors (D2Rs).

179 turn, inhibits the activity of CINs through dopamine D2 receptors (D2Rs).

180 enes implicated in impulsivity, encoding the dopamine D2 receptor (DA D2R) and the 5-HT2c receptor (5

181 oral responses previously found to relate to dopamine D2 receptor density (responsivity to tactile st

182 olinska Scales of Personality are related to dopamine D2 receptor density and extends this finding by

183 tal retardation homologue FXR1 and regulates dopamine D2 receptor density.

184 er the frontal cortex of awaken mice induces dopamine D2 receptor dependent persistent changes of CDK

185 This is associated with dopamine D2 receptor-dependent increased striatal protei

186 escence also increased the expression of the dopamine D2 receptor, dopamine transporter, and adenosin

187 red food reinforcement, polymorphisms of the dopamine D2 receptor (DRD2) and dopamine transporter (DA

188 e D1 receptor (DRD1) antagonist SCH 23390 or dopamine D2 receptor (DRD2) antagonist sulpiride into th

189 We have previously identified a dopamine D2 receptor (DRD2) coexpression module enriched

190 ength polymorphism, which is associated with dopamine D2 receptor (DRD2) gene binding in the striatum

191 on of DTNBP1 siRNA on cell surface levels of dopamine D2 receptor (DRD2) in human SH-SY5Y neuroblasto

192 ted the sensitivity of the microPET to image dopamine D2 receptor (DRD2) KO mice (D2-/-).

193 Subcortical dopamine D2 receptor (DRD2) signaling is implicated in c

194 e LH in a way that is partially dependent on dopamine D2 receptors (DRD2).

195 These dopamine D2 receptor-enriched modules may play an import

196 ve symptoms of schizophrenia by antagonizing dopamine D2 receptors expressed by striatal spiny projec

197 hat was induced by activation of recombinant dopamine D2 receptors expressed in C6 glioma and human e

198 e dendritic spine morphology specifically in dopamine D2 receptor expressing MSNs (D2-MSNs).

199 iological analysis of thick-tufted, putative dopamine D2 receptor expressing, layer V pyramidal neuro

200 II of the PrL, p11 is highly concentrated in dopamine D2 receptor-expressing (D2(+)) glutamatergic ne

201 a balanced loss of NMDARs from both D1R and dopamine D2 receptor-expressing (D2R) MSNs is permissive

202 GLP-1 receptors on dopamine D1 receptor- and dopamine D2 receptor-expressing medium spiny neurons in

203 ic nicotine (cNIC) on synaptic plasticity in dopamine D2 receptor-expressing medium-spiny neurons in

204 itored population-level Ca(2+) activities of dopamine D2-receptor-expressing medium spiny neurons (D2

205 ens (NAcc) as well as MSN-D2 (MSN-expressing dopamine D2 receptors) from the shell of NAcc.

206 Pharmacological manipulation of dopamine D2 receptor function with quinpirole (agonist)

207 oduction of the R1441C mutation also impairs dopamine D2 receptor function, as suggested by decreased

208 e present results provide a key link between dopamine D2 receptor function, impulsivity, and frontost

209 e highly enriched in striatum, in modulating dopamine D2 receptor function.

210 The human dopamine D2 receptor gene (DRD2) has three polymorphic v

211 Absence of the murine dopamine D2 receptor gene (drd2) produces bradykinesia a

212 A SNP (rs17601612) in the dopamine D2 receptor gene (DRD2) was significantly assoc

213 lymorphisms, rs2283265 and rs1076560, in the dopamine D2 receptor gene (DRD2) were found to be signif

214 viates the transcriptional inhibition of the dopamine D2 receptor gene by mutant htt.

215 verses the transcriptional inhibition of the dopamine D2 receptor gene caused by mutant huntingtin, a

216 The dopamine D2 receptor has two splice variants, D2S (Short

217 We show that blockade of dopamine D2 receptors has profound effects on the functi

218 reatly reduced FAA, whereas mice lacking the dopamine D2 receptor have normal FAA.

219 express a signaling-deficient form of human dopamine D2 receptor (hD2R).

220 ant DNA technique to investigate the role of dopamine D2 receptor in rhinal cortex for this type of l

221 d expression of the dopamine transporter and dopamine D2 receptor in the NAc shell of postpartum fema

222 Opioid stimulation of JNK also inactivates dopamine D2 receptors in a PRDX6-dependent manner.

223 ine activity we measured the availability of dopamine D2 receptors in brain.

224 The authors have shown that decreases in dopamine D2 receptors in cocaine abusers were associated

225 sing increased the amount or availability of dopamine D2 receptors in dominant monkeys and produced n

226 Here, we demonstrate that overexpression of dopamine D2 receptors in medium spiny neurons increases

227 re to identify a surrogate biomarker for the Dopamine D2 receptors in the brain by comparing patients

228 After demonstrating dopamine D2 receptors in the glomerular and olfactory ne

229 Our results indicate that quinpirole acts at dopamine D2 receptors in the nucleus accumbens to inhibi

230 We found that blocking dopamine D2 receptors in the retina during the day mimic

231 are glutamatergic and regulated primarily by dopamine D2 receptors in the striatum.

232 study was undertaken to examine the role of dopamine D2-receptors in the regulation of neurotensin r

233 We report that dopamine-D2 receptors induce PKA Calpha translocation an

234 expression greatly accelerated the decay of dopamine D2 receptor-induced GIRK current.

235 Dopamine D2 receptor interactions with arrestins and arr

236 dependent manner and a PKC inhibitor blocked dopamine D2 receptor internalization.

237 Signaling through the dopamine D2 receptor is critical for all of these proces

238 that agonist-induced internalization of the dopamine D2 receptor is regulated by the receptor tyrosi

239 Activation of dopamine D2 receptors is known to potently modulate stri

240 f the radioligand 11C-labelled raclopride to dopamine D2 receptors is sensitive to levels of endogeno

241 n the third membrane-spanning segment of the dopamine D2 receptor, is exposed in the binding-site cre

242 Together with the dopamine D2 receptor it is highly expressed in striatal

243 Stress and dopamine D2 receptor levels (DRD2) have been shown to pl

244 Although ventral prefrontal dopamine D2 receptor levels predict "perseverative" erro

245 This study assessed whether brain dopamine D2 receptor levels, which show significant inte

246 in the analysis of tyrosine hydroxylase and dopamine D2 receptor levels.

247 The binding site of the dopamine D2 receptor, like that of homologous G-protein-

248 The binding site of the dopamine D2 receptor, like that of homologous G-protein-

249 The binding-site of the dopamine D2 receptor, like that of other homologous G pr

250 The binding site of the dopamine D2 receptor, like that of other homologous G pr

251 The binding site of the dopamine D2 receptor, like that of other homologous G-pr

252 methods to study genetic linkage between the dopamine D2 receptor locus and alcoholism.

253 Here, we reveal that dopamine D2 receptor mediated inhibition of striatal cho

254 adenylyl cyclase activity while suppressing dopamine D2 receptor-mediated inhibition.

255 These data demonstrate that basal ganglia dopamine D2 receptor-mediated neurotransmission is invol

256 ryonic kidney 293 cells completely abolished dopamine D2 receptor-mediated potentiation of AC2 activi

257 This was accomplished by examining the dopamine D2 receptor-mediated synaptic current that resu

258 ing offspring did not experience the loss of dopamine D2 receptor mRNA characteristic of HD mice, and

259 A dopamine D2 receptor mutation was recently identified in

260 The stimulation of dopamine D2 receptors negatively regulates the angiogeni

261 gical investigations of bivalent ligands for dopamine D2 receptor/neurotensin NTS1 receptor (D2R/NTS1

262 ride positron emission tomography to measure dopamine D2 receptor occupancy by the endogenous transmi

263 counter-therapeutic functional adaptation to dopamine D2 receptor occupancy required for medication e

264 tal dopamine levels rather than insufficient dopamine D2 receptor occupancy.

265 irst direct evidence for the localization of dopamine D2 receptors on striatal cholinergic interneuro

266 eceptor mechanisms: (1) direct inhibition by dopamine D2 receptors on the cholinergic neurons, and (2

267 e have mapped the homodimer interface in the dopamine D2 receptor over the entire length of the fourt

268 Aripiprazole is a dopamine D2 receptor partial agonist with partial agonis

269 Antagonism of GABA(B) receptors or dopamine D2 receptors partially reversed the reduction i

270 Dopamine D2 receptor-promoted activation of Galpha(o) ov

271 Bromocriptine, acting through the dopamine D2 receptor, provides robust protection against

272 (WT, C57BL/6J) animals were imaged with the dopamine D2 receptor radioligand (11)C-raclopride, the P

273 (WT, C57BL/6J) animals were imaged with the dopamine D2 receptor radioligand (11)C-raclopride, the P

274 ron emission tomography and [11C]raclopride (dopamine D2 receptor radioligand sensitive to competitio

275 erwent positron emission tomography with the dopamine D2 receptor radiotracer carbon 11-labeled FLB45

276 ose with substance abuse disorders may share dopamine D2 receptor-related vulnerabilities, and opposi

277 Here, we report that the dopamine D2 receptor selectively modulates the neural ac

278 conditional transgenic mouse overexpressing dopamine D2 receptors selectively in the striatum.

279 chizophrenia risk, including potentially the dopamine D2 receptor short isoform.

280 hysiological studies identified a deficit in dopamine D2 receptor signaling in the BLA of Lmo4-defici

281 tor complex and is involved in mu-opiate and dopamine D2 receptor signaling, both of which are though

282 ium activity can be dynamically modulated by dopamine D2 receptor signaling.

283 lity trait involving personal detachment and dopamine D2 receptor specific binding in healthy subject

284 Atypical melanotrophs remain competent for dopamine D2 receptor stimulation and undergo S-phase apo

285 tribution of a recently cloned member of the dopamine D2 receptor subfamily, the D3 receptor, has led

286 red including dopamine transporter (DAT) and dopamine D2 receptor subtype (D2r) ligand levels as well

287 ur-residue segment (residues 212-215) of the dopamine D2 receptor that is necessary for arrestin bind

288 In MSNs presumably expressing dopamine D2 receptors, tLTP, the main form of plasticity

289 In the dopamine D2 receptor, top CovET residue pairs recovered

290 These results indicate that ALK regulates dopamine D2 receptor trafficking, which has implications

291 agonist N-propylnorapomorphine (NPA) to the dopamine D2 receptor was also examined.

292 A homology model of the dopamine D2 receptor was constructed based on the crysta

293 The availability of dopamine D2 receptor was decreased in obese individuals

294 ools for the highly therapeutically relevant dopamine D2 receptor, we synthesized a collection of ago

295 Using light microscopy, dopamine D2 receptors were localized on the cell somata

296 The dopamine D2 receptor, which attenuates acetylcholine rel

297 zophrenia symptoms through the antagonism of dopamine D2 receptors, which are abundant mainly in subc

298 lso implicated, the dorsal striatum, rich in dopamine D2 receptors, which are antagonized by antipsyc

299 ssing a wild-type G alpha(i) subunit and the dopamine D2 receptor with the agonist ligand nor-apomorp

300 Reduction of dopamine signaling through the dopamine D2 receptor with the use of gene knockouts in C