ライフサイエンスコーパス: dopamine beta-hydroxylase

1 ted to myenteric ganglia by the promoter for dopamine beta-hydroxylase.

2 ogous to the N-terminal regulatory region of dopamine beta-hydroxylase.

3 e oxidase, ceruloplasmin, lysyl oxidase, and dopamine beta-hydroxylase.

4 s-responsive genes, tyrosine hydroxylase and dopamine beta-hydroxylase.

5 reactivity for choline acetyltransferase and dopamine beta-hydroxylase.

6 naline by inactivating the gene that encodes dopamine beta-hydroxylase.

7 tic pathway enzymes tyrosine hydroxylase and dopamine beta-hydroxylase.

8 isplay immunoreactivity for dopamine but not dopamine beta-hydroxylase.

9 or ligands, due to a disruption the gene for dopamine beta-hydroxylase.

10 eneration of norepinephrine from dopamine by dopamine beta-hydroxylase.

11 es directed against tyrosine hydroxylase and dopamine-beta-hydroxylase.

12 nthesizing enzymes, tyrosine hydroxylase and dopamine-beta-hydroxylase.

13 Analyses of noradrenergic (dopamine-beta-hydroxylase) afferents revealed no differe

14 rving as a cofactor to superoxide dismutase, dopamine-beta-hydroxylase, amyloid precursor protein, ce

15 and consequent lipolysis, as do knockouts of dopamine beta-hydroxylase, an enzyme required for catech

16 nce for the noradrenergic transmitter enzyme dopamine beta-hydroxylase and by using catecholamine his

17 ased the density of axons immunoreactive for dopamine beta-hydroxylase and for serotonin.

18 found to coexist at significant levels with dopamine beta-hydroxylase and hence it is likely that th

19 orms of granule membrane proteins, including dopamine beta-hydroxylase and peptidyl glycine alpha-ami

20 Recent evidence has shown that the genes for dopamine beta-hydroxylase and the dopamine transporter S

21 For the catecholamine biosynthetic enzymes, dopamine beta-hydroxylase and tyrosine hydroxylase, regu

22 press the adrenergic differentiation markers dopamine beta-hydroxylase and tyrosine hydroxylase.

23 criptional complex that drives expression of dopamine-beta-hydroxylase and can also up-regulate expre

24 r these substances as well as for serotonin, dopamine-beta-hydroxylase and met-enkephalin are observe

25 zed by dual immunohistochemical detection of dopamine-beta-hydroxylase and PRV.

26 on microscopic levels to investigate whether dopamine-beta-hydroxylase and tyrosine hydroxylase-conta

27 Direct evidence for the termination of dopamine-beta-hydroxylase and tyrosine hydroxylase-posit

28 ctive (TH-ir) axons in the PF also expressed dopamine-beta-hydroxylase and were therefore noradrenerg

29 essary but also sufficient to induce Phox2b+ dopamine-beta-hydroxylase+ and tyrosine hydroxylase+ NA

30 pment, while inhibitors of aminopeptidase A, dopamine beta-hydroxylase, and the intestinal Na(+)/H(+)

31 ds of cells expressing tyrosine hydroxylase, dopamine-beta-hydroxylase, and the SA lineage marker SA-

32 Dopamine-beta-hydroxylase- and tyrosine hydroxylase-posi

33 ats was achieved by intrathecal injection of dopamine beta-hydroxylase antibodies conjugated to the t

34 hypo-innervation utilizing a targeted-toxin (dopamine beta-hydroxylase antibody conjugated to saporin

35 ion in response to psychological stress.Anti-dopamine-beta-hydroxylase antibody conjugated to the neu

36 njections (spinal segments T2-T3) of an anti-dopamine-beta-hydroxylase antibody conjugated to the rib

37 ls with cAMP, protein complexes bound to the dopamine beta-hydroxylase AP1/cAMP response element elem

38 urons was confirmed by coimmunolabeling with dopamine beta-hydroxylase, as well as by retrograde bone

39 reactive to PHA-L, tyrosine hydroxylase, and dopamine beta-hydroxylase, but not phenylethanolamine-N-

40 titative analysis of immunocytochemistry for dopamine beta-hydroxylase, choline acetyltransferase, an

41 from 2DG-injected rats pretreated with anti-dopamine-beta-hydroxylase conjugated to saporin to lesio

42 We have shown that an antibody to dopamine-beta-hydroxylase conjugated with saporin (anti-

43 opsin2(ChR2)-mCherry (AAV2) into the RVLM of dopamine-beta-hydroxylase Cre transgenic mice (DbetaH(Cr

44 2-mCherry unilaterally into the brainstem of dopamine-beta-hydroxylase(Cre/0) mice.

45 Dopamine-beta-hydroxylase (D beta H) catalyzes the conve

46 in, coupled to the antibody directed against dopamine beta hydroxylase (DbetaH-saporin), the analgesi

47 le increase in tyrosine-hydroxylase (TH) and dopamine beta-hydroxylase (DbetaH) immunoreactive (IR) a

48 latory actions on tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DbetaH), and the norepinephri

49 omatostatin and tyrosine hydroxylase (TH) or dopamine beta-hydroxylase (DbetaH), respectively.

50 enzyme involved in catecholamine metabolism, dopamine beta-hydroxylase (DbetaH), which converts dopam

51 Quantification of dopamine beta-hydroxylase (DbetaH)-immunostained varicos

52 s carried out to investigate overlap between dopamine-beta-hydroxylase (DbetaH) -immunopositive proje

53 binding protein (pCREB) expressing nuclei in dopamine-beta-hydroxylase (DbetaH) containing cells in t

54 C noradrenergic neurons were demonstrated by dopamine-beta-hydroxylase (DbetaH) immunofluorescence.

55 Dopamine-beta-hydroxylase (DbetaH) is a copper-containin

56 of Ret (Ret(MEN2B)) under the control of the dopamine-beta-hydroxylase (DbetaH) promoter develop prof

57 We used the human dopamine-beta-hydroxylase (DbetaH) promoter to direct tr

58 tein (EGFP) under the control of a synthetic dopamine-beta-hydroxylase (DbetaH) promoter was used to

59 or and the catecholamine-synthesizing enzyme dopamine-beta-hydroxylase (DbetaH) was performed using c

60 ciated viral vectors into the brain of adult dopamine-beta-hydroxylase (DbetaH)(Cre/0) mice.

61 transporter 2 (VMAT2), serotonin (5-HT), and dopamine-beta-hydroxylase (DbetaH; a marker for norepine

62 rough serotonin, but did not directly affect dopamine beta hydroxylase (Dbh) expression in the locus

63 le cellular tasks, ATP7A transfers copper to dopamine beta hydroxylase (DBH) within the lumen of the

64 -function dramatically reduces expression of Dopamine Beta Hydroxylase (Dbh), a gene encoding a cruci

65 e visualized by immunoperoxidase labeling of dopamine beta hydroxylase (DbH), and gastric preautonomi

66 , those that express the NA synthetic enzyme dopamine beta hydroxylase (DbH)] in the caudal NST were

67 % of the total phenotypic variance in plasma dopamine beta-hydroxylase (DBH) activity in samples from

68 Dopamine beta-hydroxylase (DBH) activity was associated

69 ning them were exposed to antibodies against dopamine beta-hydroxylase (DBH) and 5-HT.

70 NE synthesis, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) are absent.

71 Dopamine beta-hydroxylase (DBH) catalyzes the conversion

72 Dopamine beta-hydroxylase (DBH) catalyzes the production

73 Human norepinephrine (NE) deficiency (or dopamine beta-hydroxylase (DBH) deficiency) is a rare co

74 ble for normal tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) expression in sympatheti

75 uppression was found to be downregulation of dopamine beta-hydroxylase (DBH) gene expression, encodin

76 To examine if Egr1 also regulates dopamine beta-hydroxylase (DBH) gene expression, PC12 ce

77 The dopamine beta-hydroxylase (DBH) gene is expressed select

78 e investigated by targeted disruption of the dopamine beta-hydroxylase (Dbh) gene, thereby eliminatin

79 ) were created by targeted disruption of the dopamine beta-hydroxylase (DBH) gene.

80 tablished in vitro by retrograde tracing and dopamine beta-hydroxylase (DBH) immunocytochemistry.

81 biosynthetic genes tyrosine hydroxylase and dopamine beta-hydroxylase (DBH) is regulated by cell typ

82 Dopamine beta-hydroxylase (DBH) is the biosynthetic enzy

83 deficiency in an AD mouse model, we crossed dopamine beta-hydroxylase (DBH) knockout mice with amylo

84 We previously showed that ethanol regulates dopamine beta-hydroxylase (DBH) mRNA and protein levels

85 Tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) mRNA expression in postm

86 Our approach also allowed us to identify dopamine beta-hydroxylase (dbh) positive ganglion cells

87 Inhibition of dopamine beta-hydroxylase (DBH) results in a decrease in

88 hetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) was examined.

89 EC responses to CSD in mice deficient in NE [dopamine beta-hydroxylase (Dbh)(-/-)] and control male a

90 In mice lacking dopamine beta-hydroxylase (DBH), an enzyme critical for

91 al peptide (VIP), tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and muscarinic and alph

92 at the neurotransmitter synthesizing enzyme, dopamine beta-hydroxylase (DBH), could selectively destr

93 ct (NTS), marked by expression of the enzyme dopamine beta-hydroxylase (DBH), in female mice.

94 ary expresses both the genes encoding TH and dopamine beta-hydroxylase (DBH), the key enzymes in nore

95 nergic neurons by inducing the expression of dopamine beta-hydroxylase (DBH), the terminal enzyme for

96 the CB1 receptor population specifically in dopamine beta-hydroxylase (DBH)-expressing cells is both

97 ify cholecystokinin (CCK) and noradrenergic, dopamine beta-hydroxylase (DBH)-expressing NTS neurons a

98 putative monooxygenase with low homology to dopamine beta-hydroxylase (DBH).

99 iosynthetic enzymes tyrosine hydroxylase and dopamine beta-hydroxylase (DBH).

100 sed with the norepinephrine-synthetic enzyme dopamine beta-hydroxylase (DBH).

101 otypes of mice lacking NE due to mutation of dopamine beta-hydroxylase (dbh).

102 Gal-immunoreactive fibers did not co-contain dopamine beta-hydroxylase (DBH).

103 is a clear sequence homologue of the enzyme dopamine beta-hydroxylase (DBH).

104 )-diaphorase, tyrosine hydroxylase (TH), and dopamine beta-hydroxylase (DBH).

105 including the NTS neurons immunoreactive to dopamine beta-hydroxylase (DBH).

106 By comparing the number and distribution of dopamine beta-hydroxylase (DBH)/cholinergic appositions,

107 Ethanol treatment elevated dopamine beta-hydroxylase (DBH, EC 1.14.17.1) mRNA and p

108 question genetically by using mice that lack dopamine beta-hydroxylase (dbh-/- mice).

109 Gene-targeted mice that lack dopamine beta-hydroxylase (dbh-/-), the enzyme needed to

110 at express the dopamine transporter (DAT) or dopamine beta-hydroxylase (DBH; marker of noradrenergic/

111 of endogenous tyrosine hydroxylase (TH) and dopamine-beta hydroxylase (DBH) gene expression in these

112 Finally, immunohistochemical staining of dopamine-beta-hydroxylase (DBH) containing cells confirm

113 Dopamine-beta-hydroxylase (DBH) is the penultimate enzym

114 produce a targeted gene knockdown of NPY and dopamine-beta-hydroxylase (DBH), a catecholamine biosynt

115 here the immunocytochemical distribution of dopamine-beta-hydroxylase (DBH), a noradrenergic marker,

116 immunoreactive neurons was also labeled for dopamine-beta-hydroxylase (DBH), an enzyme involved in n

117 tudy compared the distribution and number of dopamine-beta-hydroxylase (DBH)- and phenylethanolamine-

118 eptide (VIP), tyrosine hydroxylase (TH), and dopamine-beta-hydroxylase (DBH).

119 i-enzymatic pathway that includes the enzyme dopamine-beta-hydroxylase (DBH).

120 ation of the norepinephrine synthetic enzyme dopamine-beta-hydroxylase (DBH).

121 eage products (tyrosine hydroxylase, Th, and dopamine beta-hydroxylase, Dbh) are markedly altered.

122 (encoding tyrosine hydroxylase, Th) and Dbh (dopamine beta-hydroxylase, Dbh) mRNA, whereas several ot

123 on 3 young patients with recently documented dopamine beta-hydroxylase deficiency at a single institu

124 We tested this hypothesis in vivo using dopamine beta-hydroxylase-deficient mice (DBH -/-), whic

125 Dopamine beta-hydroxylase-deficient mice (Dbh-/-), lacki

126 orin toxin conjugated to an antibody against dopamine beta hydroxylase (DSAP) was microinjected bilat

127 tity to the evolutionarily related mammalian dopamine beta-hydroxylase enzyme.

128 addition to the role of c-Fos in regulating dopamine beta-hydroxylase gene expression in response to

129 The 5'-flanking -1012C --> T variant of the dopamine beta-hydroxylase gene was slightly increased an

130 pinephrine due to targeted disruption of the dopamine beta-hydroxylase gene, Dbh, were used to critic

131 ional activation of tyrosine hydroxylase and dopamine beta-hydroxylase genes after repeated episodes

132 In addition, dopamine-beta-hydroxylase immunohistochemistry, employed

133 Previous studies have demonstrated dopamine-beta-hydroxylase immunoreactive (DBH-ir) fibers

134 of the A15 dorsal group and the very sparse dopamine-beta-hydroxylase immunoreactive fibers and vari

135 d, only tyrosine hydroxylase fibers, and not dopamine-beta-hydroxylase immunoreactive fibers, were lo

136 No dopamine-beta-hydroxylase immunoreactive perikarya were

137 Dopamine beta-hydroxylase-immunoreactive sympathetic ner

138 the density of tyrosine hydroxylase- but not dopamine-beta-hydroxylase-immunoreactive axons in sensor

139 Both tyrosine hydroxylase- and dopamine-beta-hydroxylase-immunoreactive fibers and punc

140 both tyrosine hydroxylase-immunoreactive and dopamine-beta-hydroxylase-immunoreactive) were also quan

141 ntaining tyrosine hydroxylase perikarya, but dopamine-beta-hydroxylase immunoreactivity was very spar

142 ed lower activities of monoamine oxidase and dopamine beta hydroxylase in the hippocampus and prefron

143 f cardiomyocytes expressing Dbhgene encoding dopamine beta-hydroxylase in murine heart.

144 both noradrenaline (NA) and NA-synthesizing dopamine beta-hydroxylase in the peripheral nervous syst

145 le responses to male song and the density of dopamine-beta-hydroxylase in area X and another song nuc

146 assaying axons immunoreactive for the enzyme dopamine-beta-hydroxylase in representative areas of acu

147 These neurons were immunopositive for dopamine beta-hydroxylase, indicating that they were cat

148 ent and showed previously that the selective dopamine beta-hydroxylase inhibitor, nepicastat, had no

149 ented here examined tyrosine hydroxylase and dopamine-beta-hydroxylase innervation in hormonally inta

150 NPY knock-out (NPY KO) and dopamine beta-hydroxylase knock-out (DBH KO) mice that l

151 Here, we exposed dopamine beta-hydroxylase knock-out (Dbh(-/-)) mice, whi

152 sting by telemetrically monitoring the Tb of dopamine beta-hydroxylase knock-out (Dbh-/-) mice, which

153 etion on ethanol-mediated behaviors by using dopamine beta-hydroxylase knockout (Dbh -/-) mice that s

154 Additionally, dopamine beta-hydroxylase knockout (Dbh(-)(/)(-)) mice t

155 vement tests and examining motor deficits in dopamine beta-hydroxylase knockout (Dbh-/-) mice that la

156 psychostimulant responses by testing LRA in dopamine beta-hydroxylase knockout (Dbh-/-) mice that la

157 rmed transverse aortic constriction (TAC) in dopamine beta-hydroxylase knockout mice (Dbh(-/-), genet

158 d after treatment with NE inhibitors, and in dopamine beta-hydroxylase knockout mice (which cannot sy

159 This genomic region harbors monooxygenase dopamine beta-hydroxylase-like 1 gene (MOXD1), implicate

160 In a separate study, TH-ir and dopamine-beta-hydroxylase-like immunoreactivity (DBH-ir)

161 ing in vitro, and cAMP- and Phox2a-dependent dopamine-beta-hydroxylase-luciferase reporter expression

162 Dopamine beta-hydroxylase (-/-) mice are unable to synth

163 Seizure susceptibility was determined in the dopamine beta-hydroxylase null mutant (Dbh -/-) mouse us

164 immunotoxin, saporin-conjugated antiserum to dopamine-beta-hydroxylase, on acute restraint stress-ind

165 s that immunostain for tyrosine hydroxylase, dopamine beta-hydroxylase, or neuropeptide Y.

166 were used to investigate the distribution of dopamine-beta-hydroxylase- or tyrosine-hydroxylase-label

167 tyrosine hydroxylase, L-dopa decarboxylase, dopamine beta-hydroxylase, phenylethanolamine-N-methyltr

168 to demonstrate PHA-L, tyrosine hydroxylase, dopamine beta-hydroxylase, phenylethanolamine-N-methyltr

169 Brainstem sections were stained for c-Fos, dopamine beta-hydroxylase, phenylethanolamine-N-methyltr

170 ted by tyrosine hydroxylase-positive but not dopamine-beta-hydroxylase-positive fibers, suggesting do

171 ic neurons were in close proximity to single dopamine-beta-hydroxylase-positive varicosities, others,

172 under control of the noradrenergic-specific dopamine beta-hydroxylase promoter (DBH-hSNCA).

173 mid inhibits cAMP-mediated expression of the dopamine beta-hydroxylase promoter construct in PC12 and

174 ediated regulation of transcription from the dopamine beta-hydroxylase promoter is mediated by the AP

175 via an improved Cre recombinase driven by a dopamine beta-hydroxylase promoter resulted in neuroblas

176 Transgenic mice were created using the dopamine beta-hydroxylase promoter to direct expression

177 t then reconverge on a single element in the dopamine beta-hydroxylase promoter to elicit activation

178 overexpress galanin under the control of the dopamine beta-hydroxylase promoter to study the neuroche

179 SHP-2 mutant under the control of the human dopamine beta-hydroxylase promoter.

180 d from neonatal lethality by expression of a dopamine beta-hydroxylase promoter/ET(B) receptor transg

181 ce that overexpress the galanin gene under a dopamine-beta-hydroxylase promoter (GalOE).

182 activated H-Ras in transgenic mice using the dopamine-beta-hydroxylase promoter, which directs expres

183 reen fluorescent protein under an artificial dopamine beta-hydroxylase (PRSx8) promoter to trace the

184 e spatiotemporal expression of TH, 5-HT, and dopamine beta hydroxylase reactivity, we determined that

185 Immunostaining for dopamine beta-hydroxylase revealed fibers within dopamin

186 Anti-dopamine beta-hydroxylase-saporin toxin (DbetaH-SAP) was

187 ntracerebroventricularly with saline or anti-dopamine-beta-hydroxylase-saporin, a toxin that destroys

188 Intracerebroventricular anti-dopamine beta-hydroxylase/saporin, a treatment that dest

189 mpensatory endocytosis assessed by measuring dopamine-beta-hydroxylase (secretory granule membrane) i

190 iosynthetic enzymes tyrosine hydroxylase and dopamine beta-hydroxylase, suggesting a role for ARIX in

191 tained for tyrosine hydroxylase, but not for dopamine-beta-hydroxylase, suggesting that these axonal

192 s of co-localization of immunoreactivity for dopamine beta-hydroxylase (the synthetic enzyme for nora

193 both the alpha-2(A) adrenergic receptor and dopamine beta-hydroxylase, the enzyme necessary for NE s

194 We used mice lacking the gene coding for dopamine beta-hydroxylase, the enzyme responsible for sy

195 s transcripts encoding NET, NET protein, and dopamine beta-hydroxylase; these neurons lack tyrosine h

196 kers, compared with tyrosine hydroxylase and dopamine beta-hydroxylase, to reflect the extent of adre

197 ious studies indicating direct activation of dopamine beta-hydroxylase transcription by Phox2a/2b, th

198 2 and regulation of tyrosine hydroxylase and dopamine beta-hydroxylase transcription was confirmed in

199 NE and dopamine beta-hydroxylase were increased by 3.8- and 10.

200 ies against 5-HT and the NA precursor enzyme dopamine beta-hydroxylase were utilized to examine the d

201 econd key noradrenergic biosynthetic enzyme, dopamine beta-hydroxylase, which is instead regulated by