ライフサイエンスコーパス: dormant

1 grows out to give a lateral shoot or remains dormant.

2 enesce, and the below-ground rhizomes become dormant.

3 ection, HIV can actively replicate or remain dormant.

4 eminated cancer cells (DCCs) that can remain dormant.

5 echnically more challenging and has remained dormant.

6 icing in the analysed mRNAs, thereby leaving dormant a cellular response pathway to these man-made en

7 rosslinked networks, possess a unique, often dormant ability to activate one or more forms of stimuli

8 Although the epicardium becomes dormant after birth, cardiac injury reactivates developm

9 stasis, why breast cancer cells often become dormant after homing to bone is not well understood.

10 ctron microscopy (EM) reveals an ensemble of dormant AKAP79-PP2B configurations varying in particle l

11 n interscales, which contain both mature and dormant amelanotic melanocytes.

12 ivation, allowing a dynamic switch between a dormant and an activated state.

13 Seeds are dormant and desiccated structures, filled with storage p

14 the cidal activity of bSi on growing cells, dormant and germinated spores of B. subtilis, and dorman

15 d set environment and therefore frequency of dormant and non-dormant seed states.

16 some-associated transcripts differed between dormant and nondormant seeds and revealed actors in seed

17 of magnitude in seed size and including both dormant and nondormant seeds.

18 exposed to aerobic conditions did not become dormant and progressed through several developmental sta

19 and epistatic interactions with other summer dormant and stress responsive QTL regions for plant heig

20 cause the biofilms contain subpopulations of dormant antibiotic-tolerant cells.

21 efense against environmental cold but become dormant as mammals habituate to warm environments.

22 ble intracellular pathogen, existing in both dormant as well as active disease-causing states.

23 ion, and seeds survived in the soil remained dormant at the excavation.

24 s of viable coccoids with characteristics of dormant bacteria that might be important in H. pylori in

25 in microcolonies containing both growing and dormant bacteria.

26 This supports a model in which dormant, balanced NEO1(-) Hoxb5 (+) LT-HSCs can hierarch

27 phagy and this event enables Pfkfb3 to drive dormant BCSCs and metastatic lesions to recur.

28 phagy restores aberrant Pfkfb3 expression in dormant BCSCs, leading to their reactivation of prolifer

29 temperatures and then interconvert between "dormant beige" and "active beige" phenotypes (i.e., beig

30 ng planktonic bacteria but not metabolically dormant biofilm cells.

31 h-density regions of the early Universe; yet dormant black holes of this high mass have not yet been

32 This novel in vivo model for dormant blasts will facilitate the dissection of the nic

33 vel, nontoxic therapeutic strategy to target dormant breast cancer cells based on systemic administra

34 In an immunodeficient mouse model of dormant breast cancer, this therapy sensitized breast ca

35 Dormant breast cancers resurge as metastatic disease aft

36 The meristem identity was altered in dormant buds of transgenic tubers.

37 Studies have stipulated that resting dormant buds on hops require a minimum chilling duration

38 Consistently, sorbitol accumulates in dormant buds showing higher PpeS6PDH expression.

39 decreases in oxygen availability within the dormant buds.

40 We show that these starved cells are not dormant but are growing and dividing, albeit with a doub

41 addition, we found that these cells were not dormant but were generating unspliced RNA transcripts be

42 Spores are usually regarded as biochemically dormant, but our findings demonstrate that rather than b

43 tise, seeds are rarely either dormant or non-dormant, but seeds whose dormancy-inducing pathways are

44 elop over the course of years as a result of dormant cancer cells that disseminate to secondary sites

45 esized that the polymers were active against dormant cancer cells.

46 rulent lifestyle, (systemic infection), to a dormant carrier state.

47 cally establishing HT-driven self-renewal of dormant CD133(hi)/ER(lo) cells mediating metastatic prog

48 B biosynthesis precedes the formation of the dormant cell type called the spore (sporulation), the di

49 pore germination or by simply remodeling the dormant cell wall has been the subject of much debate.

50 er survivors could eliminate relapse causing dormant cells and offer a cure for cancer.

51 These dormant cells are often resistant to conventional hormon

52 ese findings characterize the persistence of dormant cells at metastatic sites, where soft microenvir

53 aracteristics were reversible, as resistant, dormant cells became sensitive to treatment and started

54 AD, or genetic deletion of YAP1, all deplete dormant cells by enhancing EGFR/MEK inhibition-induced a

55 The dormant cells can repopulate the biofilms following alle

56 cancer therapeutics effective in eliminating dormant cells is a significant challenge in cancer biolo

57 However, how these dormant cells resuscitate is not understood well but inv

58 wn to frequently recur in bone; however, how dormant cells switch its phenotype leading to recurrent

59 Bacterial spores are dormant cells that are encased in a thick protein shell,

60 Targeting AXL, a gene highly expressed by dormant cells, using small-molecule inhibitors released

61 ' (Rpfs) - orchestrates the resuscitation of dormant cells.

62 e active microbes from extracellular DNA and dormant cells.

63 ate rapid proton transfer between active and dormant chains.

64 e of cholestatic liver diseases, mitotically dormant cholangiocytes proliferate and subsequently acqu

65 Following Pulmonary Vein Isolation to Target Dormant Conduction Elimination) trial.

66 nopy spectrometer system and GPP at a winter-dormant conifer forest, which has little seasonal variat

67 lar ancestors, which like most protists form dormant cysts when experiencing environmental stress.

68 or, RIPK3, triggers MLKL's conversion from a dormant cytoplasmic protein into oligomers that transloc

69 Two possible present-day 'dormant' descendants of this population of 'active' blac

70 These dormant disseminated tumor cells (DTCs) may reside in cl

71 Thus, the concept of the presence of dormant dopaminergic neurons and its possibility as the

72 We propose that disinhibiting dormant dopaminergic neurons by blocking excessive astro

73 rosine hydroxylase (TH) from the TH-negative dormant dopaminergic neurons, some of which still expres

74 tions for research and the revitalisation of dormant drug-discovery programmes.

75 isms where a subpopulation of cells enters a dormant, drug-tolerant state.

76 ling restored the proliferation of otherwise dormant DTCs, enabling these cells to efficiently coloni

77 , for example, may delay germination or stay dormant during stressful periods.

78 Although most astrocytes appeared dormant during time-lapse calcium imaging, a subgroup di

79 zooplankton grazer, Daphnia pulicaria, using dormant eggs extracted from sediments in two Minnesota l

80 cle stages; eggs encapsulated in cocoons and dormant encystment stages.

81 as stimulating renewed interest in the long-dormant endosymbiont hypothesis of organelle origins.

82 n of stochastically arranged, long-lived but dormant epithelial clonal stem cells mutants.

83 ate tumors are known to remain undetected or dormant for a long period of time before they progress l

84 ACV washout, and then the viruses can remain dormant for another 3 weeks.

85 vent in breast cancer, however cells may lie dormant for many years before bone metastases develop.

86 ronically infected with T. gondii cysts, the dormant form of the parasite.

87 ica lifestyles from the infectious form to a dormant form remain unknown.

88 of dioxygen, whereas the reduced state is a "dormant form." Finally, we propose that the redox-sensin

89 ity, including the formation of quiescent or dormant forms that contribute to the establishment of lo

90 However, they are largely dormant functionally, due to IFN-I-induced negative regu

91 we showed that melanoma activated otherwise dormant functions of Schwann cells aimed at nerve regene

92 romagnetic outbursts have been detected from dormant galaxies and often attributed to the tidal disru

93 es adipocyte inflammatory vigor and uncovers dormant gene expression patterns resembling inflammatory

94 We show that dormant growth-impaired tumours from autophagy-deficient

95 Dormant hematopoietic stem cells (dHSCs) are atop the he

96 Dormant HIV genomes readily produce infectious virus upo

97 Next, we show that these endogenous but dormant homeostatic mechanisms can be harnessed to resto

98 Cs, suggesting that G-CSF does not stimulate dormant HSC proliferation.

99 vity, is highly expressed in label-retaining dormant HSCs (dHSCs).

100 Our results show that dormant HSCs are preferentially mobilized to the PB on G

101 Previous work has shown that dormant HSCs contain all the long-term repopulation pote

102 Together, our results demonstrate that dormant HSCs mobilize in response to G-CSF treatment wit

103 does not result in H2BGFP label dilution of dormant HSCs, suggesting that G-CSF does not stimulate d

104 under nanoconfined conditions this normally dormant "hydrophobicity" can emerge as the driving force

105 asites, but relapse can be prevented only if dormant hypnozoites are cleared from the liver (a treatm

106 c dataset of replicating liver schizonts and dormant hypnozoites of the relapsing parasite Plasmodium

107 s of the genomic expressions, which might be dormant in a single-source analysis.

108 expressed in ventricular myocytes (VMs) are dormant in health, yet become functional in cardiac dise

109 annels expressed in ventricular myocytes are dormant in health, yet become functional in cardiac dise

110 to manage because of their ability to remain dormant in soil for many years.

111 Hematopoietic stem cells (HSCs) are dormant in the bone marrow and can be activated in respo

112 ondition of chickenpox, the virus can remain dormant in the nervous system and may reactivate later i

113 t the natural antitumor immunity which stays dormant in the tumor-bearing host.

114 food are present (although possibly dead or dormant) in the caterpillar gut, but host-specific, resi

115 llular immune response, while establishing a dormant infection in the kidney with minimal clinical ma

116 Despite their functional heterogeneity, dormant label-retaining (LR) and non-LR hematopoietic st

117 rentiation by constraining the activation of dormant lineage-specific enhancers and promoters.

118 e single "dormant" (lipid rich, LR) and "non-dormant" (lipid poor, LP) cells with high sensitivity an

119 This approach could differentiate single "dormant" (lipid rich, LR) and "non-dormant" (lipid poor,

120 rly invasion of reticulocytes, occurrence of dormant liver forms of the parasite, and the potential f

121 Its ability to form dormant liver stages confounds control and elimination e

122 ations for P. vivax and P. ovale, which have dormant liver stages requiring primaquine.

123 parasite is driven largely by relapses from dormant liver stages, its timely elimination will requir

124 ment with primaquine or tafenoquine to clear dormant liver stages.

125 lood-stage parasites plus primaquine against dormant liver-stage forms (hypnozoites), however drug re

126 Relapses arising from dormant liver-stage Plasmodium vivax parasites (hypnozoi

127 lthough quiescence has long been viewed as a dormant, low-activity state, increasing evidence suggest

128 ed LTRs is even higher, because we show that dormant LTR promoter activity can rescue loss of an esse

129 es between the vegetative lytic fate and the dormant lysogenic fate.

130 Dormant M. tuberculosis induced quiescence in MSCs and p

131 ch serve as a long-term natural reservoir of dormant M. tuberculosis.

132 ic inflammation is a key factor in awakening dormant malignant cells at the primary site, leading to

133 cancer-free individuals because of harboring dormant malignant cells in our organs.

134 lly for translational activation of specific dormant maternal mRNAs.

135 oductive phase the arrested SAM behaves as a dormant meristem, and they strongly support AP2 as a mas

136 phase behave at the transcriptomic level as dormant meristems, with low mitotic activity and high ex

137 nd the canonical NFkappaB pathway promotes a dormant, metastatic phenotype in ER(+) breast cancer and

138 tes expansion of stem/basal-like cells and a dormant, metastatic phenotype in ER(+) breast cancer cel

139 ive community shift causes the proportion of dormant microbial taxa to double, from 45 to 90%, and in

140 ogenesis is essential for the progression of dormant micrometastases to rapidly growing and clinicall

141 We produced dormant model-organism cultures using an acidification m

142 een posited to activate the proliferation of dormant mutated cells, thus generating actively growing

143 Our analyses show that dormant myeloma cells express a distinct transcriptome s

144 to sequence the transcriptome of individual dormant myeloma cells from the bones of tumor-bearing mi

145 Drug-resistant dormant myeloma cells that reside in specific niches wit

146 omprises potential drug targets to eradicate dormant myeloma cells.

147 When dormant naive T cells first become activated by antigen-

148 icant population of TH-negative/DDC-positive dormant neurons surrounded by numerous GABA-positive ast

149 sociation of the ynoate from a catalytically dormant nickelacyclopentadiene intermediate prior to tur

150 Higher resilience is typically ascribed to "dormant" non-growing cellular states.

151 Bacteria can become dormant or form spores when they are starved for nutrien

152 In practise, seeds are rarely either dormant or non-dormant, but seeds whose dormancy-inducin

153 growth states have been recently defined as dormant or persistent.

154 A20ox4 is mutated, axillary meristems remain dormant or produce secondary shoots terminated by inflor

155 umor cells (DTCs) may resist therapy and lay dormant or progress to cause overt bone and visceral met

156 p that determines whether microtumors remain dormant or progresses further.

157 ydroxyurea treatment, suggesting it may be a dormant origin activated in response to replicative stre

158 he AT-rich fragility core of CFS, leading to dormant origin activation.

159 nd that inhibition of this signaling induces dormant origin firing at sites of ongoing replication th

160 Although both active and dormant origins bind T530-pSIRT1, active origins are dis

161 SIRT1, active origins are distinguished from dormant origins by their unique association with an open

162 abilizing compounds led to the activation of dormant origins of DNA replication, with preferential bi

163 mologues, rather than with the activation of dormant origins.

164 t Plasmodium vivax transmission or eliminate dormant P. vivax liver-stage parasites will be essential

165 d, leading to the formation of catalytically dormant palladium complexes that reactivate only upon he

166 ity is critical for survival and regrowth of dormant parasites and that RH staining provides a means

167 biological characterization and dynamics of dormant parasites are not well understood.

168 These dormant parasites can remain quiescent for months or yea

169 , a mitochondrial inhibitor, the recovery of dormant parasites was delayed or stopped.

170 in vitro, a small subset of morphologically dormant parasites was stained with rhodamine 123 (RH), a

171 Importantly, after treatment of dormant parasites with different concentrations of atova

172 ial enzymes was detected only in RH-positive dormant parasites.

173 The dormant pathogen accumulates lipid droplets containing t

174 These dormant pathogenic clones frequently express TCRs activa

175 After a >100 year dormant period during which few useful reactions of thes

176 50 years with intervals ranging from a long, dormant period of over 2,000 years, to multiple tsunamis

177 iable recurrence intervals suggest that long dormant periods may follow Sunda megathrust ruptures as

178 many lysogens, which are bacteria containing dormant phages (prophages) inserted within their genomes

179 yo remains under-developed at maturity and a dormant phase exists as the embryo continues its growth

180 lter population structure by eliminating the dormant phenotype with a 'stress-gated lysis circuit'.

181 We found that indolent cells retained the dormant phenotype, whereas aggressive cells grew rapidly

182 Persisters are dormant phenotypic variants of bacterial cells that are

183 asibility of the selective activation of our dormant photosensitizer in cellular nuclei, causing canc

184 the rare biosphere is not merely an inactive dormant population but may play substantial functional r

185 el" where cells comprising a fraction of the dormant population reinitiate growth stochastically, ind

186 (HT)-naive cells or HT-treated metabolically dormant populations with CAF-derived mtDNA(hi) EVs promo

187 illion DLPs in the past 19 years beneath the dormant postshield Mauna Kea volcano in Hawai'i.

188 ns and inhibits replication from a group of 'dormant' potential replication origins, which initiate r

189 suggests that EPAG may promote expansion of dormant preexisting clones with an aberrant karyotype.

190 icipated insults breach epithelial barriers, dormant programmes of tissue repair are immediately acti

191 Importantly, the polymer killed dormant prostate cancer cells that were resistant to doc

192 evades eradication because transcriptionally dormant proviral genomes persist in long-lived reservoir

193 adenosine testing (30 mg) was used to reveal dormant PV conduction.

194 9.5 +/- 6.8 min; p < 0.001), and lower acute dormant PV reconduction (0 of 35 vs. 5 of 35; p = 0.024)

195 All the putative summer dormant QTL regions in male map showed pleiotropic respo

196 , NSCs reside predominantly in a mitotically dormant, quiescent state, but they can proliferate in re

197 of a vinyl ether monomer bearing a secondary dormant RAFT agent, which subsequently allows side-chain

198 For several decades afterwards the idea lay dormant, regarded primarily as a mathematical curiosity.

199 The recurrence of dormant residual cells follows several distinct routes.

200 ate Notch signaling in tumor recurrence from dormant residual tumor cells and provide evidence that d

201 h signaling remains activated in a subset of dormant residual tumor cells that persist following HER2

202 The dormant resistant spores of Clostridioides difficile are

203 Immunotherapy can reinvigorate dormant responses to cancer, but response rates remain l

204 "Resurrection Ecology" (hatching dormant resting eggs deposited in the past) records evol

205 P. falciparum ring stages and DHA-pretreated dormant rings (DP-rings) using a panel of antimalarial d

206 ring daytime and nighttime, growing (GS) and dormant season (DS), have not being well studied and doc

207 nventional theory, sugar pools peaked in the dormant season and starch pools in the growing season.

208 low-severity surface burns that arise in the dormant season when vegetation is desiccated, and soil m

209 ver the growing season and decrease over the dormant season.

210 t and therefore frequency of dormant and non-dormant seed states.

211 ull phase-II water uptake of the encased non-dormant seed.

212 idopsis thaliana We planted freshly matured, dormant seeds (>180 000) representing >200 RILs at the n

213 hypothesized that the global distribution of dormant seeds derives from their adaptive value in predi

214 eased the number of dehiscent morphs and non-dormant seeds germinating in autumn.

215 ong and consistent pattern that species with dormant seeds have reduced spatial dispersal, also in th

216 d species are more likely to have large, non-dormant seeds that are dispersed far.

217 al environments, while plants bearing small, dormant seeds will be dominant under short growing seaso

218 nimals, plants can pause their life cycle as dormant seeds.

219 presence of a decision-making center within dormant seeds.

220 The liberated RNAP can either stay dormant, sequestered by HelD, or upon HelD release, rest

221 sign, preparation, and characterization of a dormant singlet oxygen ((1)O2) photosensitizer that is a

222 We demonstrate that at winter-dormant sites, seasonal changes in canopy color can be u

223 on of the bacterium Bacillus subtilis into a dormant spore is among the most well-characterized devel

224 The spore envelope, which protects the dormant spore's genome from environmental insults, uses

225 at faces starvation differentiates to form a dormant spore.

226 ut nanopillars gave no killing or rupture of dormant spores of B. subtilis, Bacillus cereus or Bacill

227 nt and germinated spores of B. subtilis, and dormant spores of several other Bacillus species by incu

228 an kill only growing bacterial cells or also dormant spores that are harder to kill.

229 ng cells to differentiate into metabolically dormant spores that can survive extreme conditions.

230 enus Calanus can spend extended periods in a dormant stage (diapause) that is preceded by the accumul

231 thereby might contribute to the switch from dormant stage to seed germination.

232 leton and energy metabolism decreased in the dormant stage.

233 The ability of myxomycetes to develop into dormant stages, which can last years, may account for th

234 ls without cytotoxicity to normal cells with dormant STAT3.

235 on toads to support quick recover from their dormant state after the heavy rain in wet season.

236 , allowing for a reliable differentiation of dormant state and exponential growth.

237 sis, arresting cancer cells in an indefinite dormant state and preventing tumor cell colonization and

238 For cells to leave the dormant state and resuscitate, clearance of protein aggr

239 A DeltatoxS mutant enters into a dormant state associated with the proteolysis of ToxR at

240 We also demonstrate resuscitation from dormant state back to exponential growth.

241 he secreted BMP7 then kept cancer cells in a dormant state by inducing senescence, reducing "stemness

242 In addition, induction of a dormant state by the inhibition of MYC, resembling diapa

243 s that survive by entering a senescence-like dormant state characterized by high YAP/TEAD activity.

244 Satellite cells (SCs) reside in a dormant state during tissue homeostasis.

245 lower's pollen remains in a low metabolic or dormant state even after hydration.

246 cells can survive treatment and persist in a dormant state for many years.

247 ew tissues can remain in a non-proliferative dormant state for years before colonizing the metastatic

248 to distinguish single viable bacteria in the dormant state from their rapidly growing, genetically id

249 t to toggle a catalyst between an active and dormant state has proven to be an effective approach for

250 ore large quantities of proteins and enter a dormant state in response to stressors.

251 Disseminated tumor cells (DTCs) undergo a dormant state in the distant metastatic site(s) before b

252 Many organisms enter a dormant state in their life cycle to deal with predictab

253 or rearrangement of the motor from a compact dormant state into a cargo binding primed state that is

254 m-line-specific mRNAs, switching them from a dormant state into a translationally active state.

255 become tolerant to antibiotics by entering a dormant state known as persistence.

256 atory elements (LREs), which may represent a dormant state of a future enhancer and contribute to mac

257 mycobacteria, the rapid resuscitation from a dormant state requires the activities of a family of cel

258 Cells can enter into a dormant state when faced with unfavorable conditions.

259 nervous system can effectively switch from a dormant state with little axonal growth to robust axon r

260 ic variants of regular cells that exist in a dormant state with low metabolic activity, allowing them

261 ion under uranium stress to enter a cellular dormant state, thereby providing an adaptive response to

262 ICM-derived mouse ESCs induces a reversible dormant state, transcriptionally mimicking the in vivo d

263 thereby allowing for prolonged survival in a dormant state, with the potential to recover self-renewa

264 t survive antibiotic treatment by entering a dormant state.

265 anisms in maintaining transformed cells in a dormant state.

266 idation and energy dissipation versus a more dormant state.

267 hus regulating their entry and exit from the dormant state.

268 influences the entry of the pathogen into a dormant state.

269 l, B-cell types that contain this virus in a dormant state.

270 reside in distal tissues and organs in their dormant state.

271 l allele is required for entry into strongly dormant states and that awake1 mutants show seed phenoty

272 Label-retaining cells (LRCs) include dormant stem cells in several tissues; in the intestine,

273 Little is known about signals that activate dormant stem cells to self-renew and regenerate odor-det

274 ng, highlighting a unique mechanism by which dormant stromal cells are enlisted for skeletal regenera

275 r L(2)', the displacement of the respective "dormant" structure releases the trigger T(1) or T(2) tha

276 A', AB', BA', and BB', and the accompanying "dormant" structures T(1)L(1) and T(2)L(2) and nicking en

277 ount for major metabolic pathways present in dormant switchgrass rhizomes.

278 While dormant, the bacteria must maintain cellular integrity,

279 jority of eDCCs were Twist1(hi)E-cad(lo) and dormant, they eventually initiated metastasis.

280 h plant vernalisation, whereby plants remain dormant through the winter before flowering in spring.

281 ular endothelial cells activate a previously dormant tip cell gene expression program, which likely u

282 The horizontal basal cell (HBC) is a dormant tissue-specific stem cell presumed to only be fo

283 nals regulate the transit of stem cells from dormant to activated states.

284 levels of abscisic acid (ABA) decreased from dormant to active stage.

285 sure to cool temperatures ('chilling') while dormant to readily initiate growth in the spring.

286 Dormant tumor cells are quiescent, and thus, do not resp

287 nces have been attributed to the presence of dormant tumor cells in breast cancer patients and cancer

288 alignant regrowth of residual drug-resistant dormant tumor cells years after primary treatment, a pro

289 Thus the regrowth of dormant tumors proceeds via multiple routes, producing r

290 therapeutic approaches are needed to target dormant tumors.

291 wed that SarcIK, ATP in single hESC-VCMs was dormant under baseline conditions, but became markedly a

292 In cold environments ectotherms can be dormant underground for long periods.

293 ced excitatory-inhibitory ensembles that lie dormant unless latent inhibitory connections are unmaske

294 Chemical systems that remain kinetically dormant until activated have numerous applications in ma

295 y Corey in 1999, this chemistry has remained dormant until our report of an enantioselective catalyti

296 to reduce the viral reservoir by activating dormant viral gene expression and directing T lymphocyte

297 the Colli Albani, it should be regarded as a dormant volcanic district, as the time of 70 kyr elapsed

298 the normal state of magma storage underneath dormant volcanoes.

299 homeostasis of inflammatory responses, lying dormant when not needed but quick to act when called upo

300 ally breaks this paradigm-the sensors remain dormant with near-zero power consumption until awakened