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2 spinal cord slice preparation with attached dorsal roots also demonstrated that CFA inflammation red
3 the sympathetic trunk or Remak fibers of the dorsal roots, although, in those structures, they wrappe
4 itudes of monosynaptic EPSCs evoked from the dorsal root and puff NMDAR currents in spinal dorsal hor
9 rmed longitudinal DCI in rats that underwent dorsal root axotomy triggering Wallerian degeneration of
10 regeneration in adult rat spinal cord after dorsal root crush and adeno-associated virus transgene e
13 n monkeys that following a combined cervical dorsal root/dorsal column lesion (DRL/DCL), both motor a
14 r a dorsal column lesion (DCL) or a combined dorsal root/dorsal column lesion (DRL/DCL), when functio
15 an established deafferentation lesion model (dorsal root/dorsal column) in male monkeys to remove sen
16 ed its efficacy in enhancing regeneration of dorsal root (DR) axons, whose regenerative capacity is p
17 sensory axons fail to regenerate across the dorsal root entry zone (DREZ) to extend into the spinal
18 sualized the entry of pioneer axons into the dorsal root entry zone (DREZ) with time-lapse imaging in
19 RG neurons failed to extend axons across the dorsal root entry zone after injury, DRG neurons in whic
20 glia regenerated through the tenascin-C-rich dorsal root entry zone into the dorsal column up to C1 l
25 mal and distal peripheral nerve segments and dorsal roots from mice and pigtail monkeys (Macaca nemes
26 eurons, termed nociceptors, are derived from dorsal root ganglia (DRG) and can undergo changes in mem
27 cleared from plasma but all persisted in the dorsal root ganglia (DRG) and sciatic nerve (SN) for up
28 hese effects correlated with degeneration in dorsal root ganglia (DRG) and sciatic nerve and abundanc
29 al dimorphism in molecular signatures of the dorsal root ganglia (DRG) and spinal cord response, not
31 and upregulation of VIP in the corresponding dorsal root ganglia (DRG) and the dorsal horn of the spi
33 tes from both PC12 cells and chick embryonic dorsal root ganglia (DRG) bodies, as well as the migrati
36 ransducing peripheral sensory neurons of the dorsal root ganglia (DRG) express kainate receptors (KAR
38 N-nitrosourea (ENU)-induced mutation affects dorsal root ganglia (DRG) formation in ouchless mutant z
39 he cell bodies of primary nociceptors within dorsal root ganglia (DRG) has been found to make major c
41 ed in primary afferent neurons isolated from dorsal root ganglia (DRG) innervating the lower gastroin
45 reases PI16 protein levels in fibroblasts in dorsal root ganglia (DRG) meninges and in the epi/perine
46 acutely dissociated small diameter (<27 mum) dorsal root ganglia (DRG) neurons and on miniature (m)EP
48 axons.SIGNIFICANCE STATEMENT Small-diameter dorsal root ganglia (DRG) neurons mediating nociception
53 e demonstrate that incubation of dissociated dorsal root ganglia (DRG) nociceptors with 1 nM BPA incr
54 n with rAAV8 would result in transduction of dorsal root ganglia (DRG) or trigeminal ganglia (TG), re
55 cantly increases the regenerative ability of dorsal root ganglia (DRG) sensory neurons compared to EE
56 nerative gene expression response in bipolar dorsal root ganglia (DRG) sensory neurons, a regeneratio
58 V infection drives pathologic changes in the dorsal root ganglia (DRG) through inflammation, altered
59 pheral nervous system from the autonomic and dorsal root ganglia (DRG) to the axon and any peripheral
60 yclooxygenase-2 (COX-2) is elevated in skin, dorsal root ganglia (DRG), and spinal cord in HbSS-BERK
61 from the sciatic nerve (SN), the lumbar 4/5 dorsal root ganglia (DRG), and the trigeminal ganglia (T
62 uronal cells in primary culture and in mouse dorsal root ganglia (DRG), as determined by the characte
63 g COX-2, EP2, EP4) in endometriosis lesions, dorsal root ganglia (DRG), spinal cord, thalamus and for
64 spinal afferents is well known to reside in dorsal root ganglia (DRG), the morphology and location o
65 sing a PER2::LUC fusion protein, we isolated dorsal root ganglia (DRG), the primary sensory cell body
67 nt increased the number of T cells in lumbar dorsal root ganglia (DRG), where CD8(+) T cells were the
77 ed in small-diameter, nociceptive neurons of dorsal root ganglia (DRGs) and is implicated in pain mod
78 tes nerve injury and inflammatory markers in dorsal root ganglia (DRGs) and spinal cord up to 2 wk af
79 , starting with gene expression profiling of dorsal root ganglia (DRGs) combined with multi-level bio
80 and sensitization responses to capsaicin in dorsal root ganglia (DRGs) following application of supe
81 -EpOME (9,10-epoxy-12Z-octadecenoic acid) in dorsal root ganglia (DRGs) of paclitaxel-treated mice as
82 pes, and its gene expression is increased in dorsal root ganglia (DRGs) of paclitaxel-treated rats.
83 e of Remak bundles, and the transcriptome of dorsal root ganglia (DRGs) provide possible explanations
89 e surgical procedure for extraction of human dorsal root ganglia (hDRG) and the necessary modificatio
90 omatin; and RNA sequencing were performed in dorsal root ganglia after sciatic nerve or dorsal column
92 show that memory CD4 T cells migrate to the dorsal root ganglia and spinal cord in response to infec
94 y addresses whether epigenetic signatures in dorsal root ganglia discriminate between regenerative an
97 een functional subtypes of sensory neuron in dorsal root ganglia is distorted by Gars mutations, lead
98 of axotomy on synaptic transmission between dorsal root ganglia neurons and dorsal horn neurons, we
99 NP)]Ts1, we were able to optically stimulate dorsal root ganglia neurons and generate action potentia
100 cetylcholine receptor (nAChR) is enriched in dorsal root ganglia neurons and is an attractive non-opi
101 model as well as in vitro effects of HOCl on dorsal root ganglia neurons and mouse bone marrow-derive
103 that in small-diameter, capsaicin-sensitive dorsal root ganglia neurons corresponding to nociceptors
104 impaired response to several pruritogens in dorsal root ganglia neurons excised from NC/Nga mice aft
105 Transcriptional profiling of IL-31-activated dorsal root ganglia neurons revealed enrichment for gene
106 , the growth cones of primary small-diameter dorsal root ganglia neurons showed abundant IL-31 recept
107 detected both KCNQ2 and KCNQ3 in a subset of dorsal root ganglia neurons that correspond to D-hair Ad
109 d sensory neurons, which account for >40% of dorsal root ganglia neurons, display resistance to rabie
110 previous reports of ASIC3 mRNA expression in dorsal root ganglia neurons, we found that the ASIC3 ant
116 10 transduces neurons in the spinal cord and dorsal root ganglia of immunodeficient mice with higher
118 ncreased activity of the Epac target Rap1 in dorsal root ganglia of WT, but not of Epac1(-/-), mice.
122 Strikingly, explant of latently infected dorsal root ganglia revealed a decreased and delayed rea
124 ons in brain and spinal cord glia as well as dorsal root ganglia satellite glia have been identified
125 ession G-protein-coupled receptors in murine dorsal root ganglia showed that both receptors were amon
126 ysiology and RNA-sequencing was performed on dorsal root ganglia taken from patients with variable pr
127 f thrombospondin-4 (TSP4) in spinal cord and dorsal root ganglia that contributes to neuropathic pain
130 the receptor PTGER2 (also called EP2) in the dorsal root ganglia to promote visceral hypersensitivity
133 anscription factor to sensory neurons of the dorsal root ganglia using a gene therapy approach and fo
134 from SNE-injured and contralateral L4 and L5 dorsal root ganglia were cultured in a compartmentalized
135 ecapitulates the selective death of sensory (dorsal root ganglia) and autonomic neurons observed in F
137 bpopulation of neurons in the trigeminal and dorsal root ganglia, but was absent in sympathetic neuro
138 the associated inflammatory processes in the dorsal root ganglia, likely by activating stress-respons
140 neuronal and non-neuronal tissues, including dorsal root ganglia, spinal cord, and keratinocytes.
141 Despite on-target activity in small-diameter dorsal root ganglia, spinal slices, and in a mouse model
142 ly, capsaicin application to the isolated L6 dorsal root ganglia, which produced robust calcium signa
155 hat CXCL12 and CXCR4 were upregulated in the dorsal root ganglion (DRG) after chronic compression of
156 sensory neuronal preparations, such as whole dorsal root ganglion (DRG) and hindpaw tissues, revealed
157 KChIP2, KChIP3, DPP6, and DPP10 in adult rat dorsal root ganglion (DRG) and spinal cord by immunohist
158 tigate mRNA expression in colonic tissue and dorsal root ganglion (DRG) cells isolated from 3- and 24
159 at a dose of 100 mpk PO due to insufficient dorsal root ganglion (DRG) exposure attributed to poor m
161 IL-6 in skin and phosphorylation of ERKs in dorsal root ganglion (DRG) in a dose-dependent manner.
162 Several recent papers have described a human dorsal root ganglion (DRG) neuron culture model and huma
163 nsgenic mice lacking Merkel cells had normal dorsal root ganglion (DRG) neuron numbers, but fewer DRG
165 hondrial trafficking plays a central role in dorsal root ganglion (DRG) neuronal cell survival and ne
166 ubcellular distribution of mammalian PATs in dorsal root ganglion (DRG) neurons and, strikingly, foun
167 P1 shows remarkably decreased RNA binding in dorsal root ganglion (DRG) neurons compared with wild-ty
169 fast-inactivating Kv3.4 potassium current in dorsal root ganglion (DRG) neurons contributes to the hy
170 voltage-gated sodium channels (VGSC) on the dorsal root ganglion (DRG) neurons controlling electrica
172 s axon growth from neurons; adult miR-155 KO dorsal root ganglion (DRG) neurons extend 44% longer neu
173 ng Na(V)1.7 mutation, which is known to make dorsal root ganglion (DRG) neurons hyperexcitable, but d
175 e find that chemogenetic activation of adult dorsal root ganglion (DRG) neurons improves axon growth
176 -expression network analysis, we categorized dorsal root ganglion (DRG) neurons into different subtyp
177 hat the activity of TRPM3 expressed in mouse dorsal root ganglion (DRG) neurons is inhibited by agoni
178 tion of G(alphaq)-coupled receptors in mouse dorsal root ganglion (DRG) neurons isolated from both se
179 es putative mechanosensitive channels in the dorsal root ganglion (DRG) neurons of these afferents.
180 mate transporter 3-lineage (Vglut3(lineage)) dorsal root ganglion (DRG) neurons play an important rol
181 uronal cell line (NG108-15) and with primary dorsal root ganglion (DRG) neurons resulted in significa
182 rophysiological characterization of isolated dorsal root ganglion (DRG) neurons revealed that RPRFami
183 Nociceptors are a particular subtype of dorsal root ganglion (DRG) neurons that detect noxious s
184 native background K(+) conductance of mouse dorsal root ganglion (DRG) neurons was examined by the w
185 sly reported that sustained ASIC currents in dorsal root ganglion (DRG) neurons were enhanced by natu
186 hat voltage-gated sodium channels (VGSCs) in dorsal root ganglion (DRG) neurons were sensitized in a
187 uring the development and differentiation of dorsal root ganglion (DRG) neurons, and on adult DRG neu
188 ts were performed on small-diameter (<30 um) dorsal root ganglion (DRG) neurons, cultured from fentan
191 ury induces changes in gene transcription in dorsal root ganglion (DRG) neurons, which may contribute
199 with microglia BV-2 cells exposed to G-CSF, dorsal root ganglion (DRG) nociceptors become hyperexcit
200 melanoma and normal neural tissues including dorsal root ganglion (DRG) produce PD-L1 that can potent
202 ort functional expression of SHANK3 in mouse dorsal root ganglion (DRG) sensory neurons and spinal co
204 ta) might act directly on nociceptors in the dorsal root ganglion (DRG) to cause pain sensitization.
205 set of nonpeptidergic nociceptors within the dorsal root ganglion (DRG), and knockdown of Kv4.3 selec
206 etermine the protein levels of P2X(3) in the dorsal root ganglion (DRG), and the whole cell patch cla
207 ceptive neurons in the adjacent uninjured L4 dorsal root ganglion (DRG), as revealed by both in vivo
209 icular pain model, local inflammation of the dorsal root ganglion (DRG), we observed marked increases
210 in nociceptor (pain-sensing) neurons of the dorsal root ganglion (DRG), where they transmit the larg
211 agi-1 are largely unknown, but we found that dorsal root ganglion (DRG)-specific knockdown of Magi-1
214 at the Ascl1 promoter, isolated from murine dorsal root ganglion (hypermethylated) and striated cell
215 conditions originate in the periphery, where dorsal root ganglion and trigeminal ganglion neurons fee
217 d force apparatus, we demonstrate that chick dorsal root ganglion axons exhibit a tension buffering o
220 y of glial cells and reduced spinal cord and dorsal root ganglion cytokine levels without affecting p
221 efficacy could be correlated with the mouse dorsal root ganglion exposure and Na(V)1.7 potency assoc
224 imulated oligodendrocytes was validated in a dorsal root ganglion microfluidics chamber platform.
225 voltage-gated sodium channel Nav1.7 underlie dorsal root ganglion neuronal hyperexcitability and pain
226 nnel isoform Na(V)1.7 is highly expressed in dorsal root ganglion neurons and is obligatory for nocic
227 illin(Cre/+) mice completely ablates MORs in dorsal root ganglion neurons and reduces the MOR express
228 ch MOR expression is completely deleted from dorsal root ganglion neurons and substantially reduced i
229 to alter TTX-S Na+ current density in medium dorsal root ganglion neurons and, importantly, mechanica
230 s reduces desensitization of native TRPV1 in dorsal root ganglion neurons as well as of recombinant T
231 f3r gene expression could not be detected in dorsal root ganglion neurons by single-cell RT-PCR.
232 n; and (5) electrophysiology recordings from dorsal root ganglion neurons collected during remission
234 cid Early 1 (RAE1), is re-expressed in adult dorsal root ganglion neurons following peripheral nerve
235 1.6 is involved in the functional changes of dorsal root ganglion neurons following vincristine treat
236 -S) and resistant (TTX-R) sodium currents in dorsal root ganglion neurons following vincristine treat
239 voltage-clamp recordings of small and medium dorsal root ganglion neurons from vincristine-treated an
242 rocytes are functional and can myelinate rat dorsal root ganglion neurons in vitro, and form myelin i
243 c or optogenetic depolarization of GABAergic dorsal root ganglion neurons in vivo reduced acute and c
244 K-2 channels was also demonstrated in native dorsal root ganglion neurons indicating that heterodimer
245 We detected increased Trpm3 mRNA levels in dorsal root ganglion neurons innervating the inflamed pa
246 t spontaneous action potential generation in dorsal root ganglion neurons is associated with radicula
248 In addition, genetically deleting GluN1 in dorsal root ganglion neurons or alpha2delta-1 genetic KO
249 affolds Na(V)1.8 and Slack K(Na) channels in dorsal root ganglion neurons regulating excitability and
250 mouse and human by a subpopulation of TRPV1+ dorsal root ganglion neurons specialized in detecting pa
251 onstellation pharmacology to investigate rat dorsal root ganglion neurons using two models of periphe
252 teers, sensitized TRPV1 in mouse nociceptive dorsal root ganglion neurons via HRH1; this effect could
253 ratching behavior and activation of cultured dorsal root ganglion neurons was dependent on Mrgprs rat
254 Retrograde labelling of bladder-projecting dorsal root ganglion neurons was used to investigate exp
258 -resistant sodium current, in small-diameter dorsal root ganglion neurons, an effect that was attenua
260 Ca(V)2 channels in mammalian cardiomyocytes, dorsal root ganglion neurons, and pancreatic beta cells.
261 calcitonin gene-related peptide (CGRP) from dorsal root ganglion neurons, and reduced inflammation i
262 1 x 10(12) vg of AAV-PHP.S transduced 82% of dorsal root ganglion neurons, as well as cardiac and ent
263 age-gated K(+) channel robustly expressed in dorsal root ganglion neurons, becomes dysfunctional upon
265 ed sustained ASIC currents in both groups of dorsal root ganglion neurons, independent of mu opioid r
267 physiology and Ca(2+) imaging experiments on dorsal root ganglion neurons, NGF- and IL-6-induced incr
268 nic spinal commissural neurons, motoneurons, dorsal root ganglion neurons, retinal ganglion cells, an
270 tion in both male and female embryonic mouse dorsal root ganglion neurons, we show that MAP4K4, MINK1
279 y processes characterized by spinal cord and dorsal root ganglion production of proinflammatory cytok
281 fer elevated intracellular calcium levels in dorsal root ganglion pruriceptors, and (iii) injection o
284 P that binds and regulates multiple mRNAs in dorsal root ganglion sensory neurons and thereby promote
286 siveness of thin fibre afferents not only at dorsal root ganglion, but also at muscle tissue levels.
287 ore variable across cultures than in primary dorsal root ganglion, particularly for genes related to
288 peripheral immune cell infiltration into the dorsal root ganglion, suggesting that adaptive immune re
289 y establishment and reactivation using human dorsal root ganglion-derived neuronal HD10.6 cells as an
290 analysis (TCA), we focused on large-diameter dorsal-root ganglion (L-DRG) neurons with myelinated axo
291 ented progression of acute poliomyelitis and dorsal root ganglionic inflammation rarely observed in C
293 eripheral nerves, but not proximal nerves or dorsal roots, is resistant to tetrodotoxin and that, in
294 , compound action potentials were made, from dorsal roots isolated from rats with or without complete
296 ral root potentials evoked by long and short dorsal root stimulation lengths, to maximize and minimiz
298 "natural" locomotor output was evoked using dorsal-root stimulation, ouabain increased burst frequen
300 B2 markedly enhances regeneration of damaged dorsal roots, while evoking little change in intact root