ライフサイエンスコーパス: dosage

1 ity depends non-monotonically on the antigen dosage.

2 achieve quiescence with increased biosimilar dosage.

3 t seen with altering the entire X chromosome dosage.

4 se its stability, localise action and reduce dosage.

5 tanding of phenotype variability due to gene dosage.

6 iers depending on genetic variation and gene dosage.

7 tion might call for individualized tamoxifen dosage.

8 de range of diseases caused by abnormal gene dosage.

9 rable CHD-linked nodes, is sensitive to TBX5 dosage.

10 riven and not explained by X chromosome gene dosage.

11 dient is highly sensitive to maternal dorsal dosage.

12 monitoring committee discontinued the APR40 dosage.

13 lent to a decrease of 50 mg/day in clozapine dosage.

14 ckness can be easily adjusted by the protein dosage.

15 apturing the evolution of time curves across dosage.

16 y consequences of graded reductions in Atoh7 dosage.

17 vely mild (15-30%) decreases in overall gene dosage.

18 expression is not strictly coupled with gene dosage.

19 ease with the cumulative oral corticosteroid dosage.

20 ipple effects of the changes in X chromosome dosage.

21 of disorders caused by alterations in SHANK3 dosage.

22 fects in MEA bursting behavior at sub-lethal dosages.

23 ich XX and XY mammals equalize X-linked gene dosages.

24 formin, and was well tolerated upon repeated dosages.

25 ystemic toxicity if taken at the recommended dosages.

26 combines haplotype clusterings with allelic dosages.

27 clinical trial with randomization to 2 drug dosages (0.5 mg and 2.0 mg ranibizumab) and 2 regimens (

28 p; median follow-up was 23 months and median dosage 15 mg/wk.

29 -of-function are also sensitive to increased dosage(6).

30 t small children would benefit from a higher dosage according to the WHO 2015 guideline.

31 umming the product of the weights and allele dosage across 6 630 149 SNPs.

32 Dosage analysis of pdx2 alleles in endosperm revealed th

33 ed a highly significant relationship between dosage and activation in bilateral insula, somatosensory

34 the relationship between changes in a gene's dosage and changes in a given disease phenotype.

35 Here, we assessed dosage and delivery of TAM for activation of Cre in immu

36 nt process is beneficial to reduce the ozone dosage and disinfection by-product formation with a broa

37 vide a basis for adjustments of drug release dosage and duration, thereby contributing to the develop

38 , we show how multiple SVs that changed gene dosage and expression levels modified fruit flavor, size

39 vation is sensitive to deficiency of SPECC1L dosage and function and that SPECC1L cytoskeletal protei

40 f their network connectivity with medication dosage and gambling behaviour.

41 proposed method captures the effects of CNV dosage and length, accounts for the numerical nature of

42 DNA segments in the genome that can vary in dosage and length.

43 There was no consensus on dosage and patient selection.

44 edback between effective RNA-binding protein dosage and protein quality control in C9, and perhaps al

45 Dosage and regimen parameters correlated directly with r

46 m human post-mortem brains to quantify their dosage and regulatory effects.

47 against ROS-mediated damage at extremely low dosage and significantly improve treatment outcomes in a

48 e parameters such as contact time, adsorbent dosage and temperature.

49 ll-molecule-controlled Cas9 system with some dosage and temporal control.

50 t gene product abundance is governed by gene dosage and that gene dosage responses are consistent for

51 was consistent in subgroup analyses by NSAID dosage and timing.

52 Many combinations of dosage and treatment time lead to stochastic outcomes, w

53 We posit that treatment timing, dosage, and COVID-19 severity determine immune response

54 astatic disease, optimizing ER-targeted drug dosage, and predicting endocrine therapy benefit.

55 the effects of altered Tbx1 and Vegfr3 gene dosage, and we show that this likely results from an ear

56 The effects of different enzymes, their dosages, and incubation times on juice yield and chemica

57 ddition, the effects of initial pH, catalyst dosages, and operation temperature on the degradation of

58 quencies of each infection, each antibiotic, dosages, and the antibiotics associated with infections

59 We find that plants with altered GRF dosage are differentially sensitive to the manipulation

60 d an approach to infer aneuploidies based on dosage-associated changes in gene expression by integrat

61 gene groups, suggesting that constraints on dosage balance operate immediately following whole-genom

62 Nonetheless, putatively dosage balance-sensitive gene groups (Gene Ontology term

63 patterns are shaped by selection to preserve dosage balance.

64 es are consistent for interacting genes in a dosage-balance-sensitive network or complex.

65 e of clinicians to TDM (adjusting or not AED dosage based on blood levels) did not explain this lack

66 ize the prevalence and trends in use of high-dosage biotin supplementation among US adults between 19

67 ase, which suggests that increased alpha-Syn dosage can drive PD.

68 gulation in TS and KS that transmit the gene dosage changes to the transcriptome.

69 Hemizygosity dosage characterization of the genes on chromosome 18 re

70 hips between individuals: encrypted genotype dosages closely resemble Gaussian deviates, and can be r

71 with vericiguat at either 15-mg/d or 10-mg/d dosages compared with placebo did not improve the physic

72 1 and 2) was elevated at the 12- and 16-g/d dosages (compared with 0-8 g/d, P < 0.05) and blood urea

73 5-mg (n = 264) or 10-mg (n = 263) daily oral dosages, compared with placebo (n = 262) and randomized

74 The ability of XIST to dosage compensate a trisomic autosome presents unique ex

75 e genetics theory predicts that X-chromosome dosage compensation (DC) will have a detectable effect o

76 tial mechanisms of reduced penetrance due to dosage compensation are discussed as a key to understand

77 nding of the Drosophila male-specific lethal dosage compensation complex (DCC) exclusively to the mal

78 ops associated with the SMC component of the dosage compensation complex (DCC) in Caenorhabditis eleg

79 raction with either CLAMP or DNA to initiate dosage compensation in Drosophila males.

80 X-chromosome dosage compensation in female placental mammals is achie

81 Dosage compensation is the process by which transcript l

82 consider the sexually dimorphic X-chromosome dosage compensation mechanisms in the prenatal germline.

83 s estimated at 0.22% (SE = 0.05) from a full dosage compensation model.

84 lantation embryos are an exception, in which dosage compensation occurs by X-chromosome dampening (XC

85 erm cell cyst samples do not exhibit obvious dosage compensation of X-chromosomal genes, even conside

86 W degeneration and simultaneous evolution of dosage compensation, provided that autosomal trans-regul

87 matin silencing machinery for sex chromosome dosage compensation.

88 mbryonic viability nor onset of X chromosome dosage compensation.

89 haploinsufficiency, reduced penetrance, and dosage compensation.

90 tures of gene degeneration and gene-specific dosage compensation.

91 e evolution of mammalian embryogenesis and X dosage compensation.

92 ctors, and can extend our understanding of X dosage compensation.

93 itial stages of sex chromosome evolution and dosage compensation.

94 e determined based on the TLSB nanocomposite dosage, concentration of zinc subgroup ions, solution pH

95 Here we show that histone dosage control by Rad53 ensures metabolic homeostasis.

96 s including different photosensitizer types, dosage controls, and different illumination times were e

97 ith acute diarrhea; in previous trials, this dosage decreased diarrhea but increased vomiting.

98 sults demonstrated that the increase of UV-A dosage decreased the aflatoxins-induced cytotoxicity in

99 ow quantitative epistasis from modified gene dosage defines background dependencies.

100 id under largely varying conditions (antigen dosage, delay between injections).

101 te the importance of explicitly modeling non-dosage dependent and intragenic epistatic effects when p

102 Dosage-dependent decrease of surface endospore germinabi

103 (Pam (Myh6-cKO/cKO)) are viable, but a gene dosage-dependent drop in atrial ANP and BNP content occu

104 The analysis detected dosage-dependent formation of the cross-link in both pur

105 t MEIOB regulates meiotic recombination in a dosage-dependent manner.

106 MS5(d) can inhibit BnMS5(a) in B. napus in a dosage-dependent manner.

107 It furthermore acts in a dosage-dependent manner.

108 Multiple dosage-dependent modifier loci on PWD chromosome 5 each

109 Here, we demonstrate dosage-dependent requirements of the exon junction compl

110 vidence is inconsistent, possibly because of dosage differences.

111 on the protein, resulting in reduced Zbtb11 dosage, downregulation of its target genes, and impaired

112 rinting regulates parent-specific transcript dosage during seed development and is mainly confined to

113 50 and 430 nm by varying the total phosphine dosage during the surface treatment step.

114 We hypothesized a FOXN1 gene dosage effect on the function of thymic epithelial cells

115 s they are related to genetic heterogeneity, dosage effect, unaffected carrier status, and incomplete

116 gous mutations in PRKN/PINK1 suggests a gene dosage effect.

117 ions are hypermorphic in some genes in which dosage effects predominate (such as TERT), whereas they

118 d on DSA perfusion may assist with real-time dosage estimation and help predict response to treatment

119 risk is higher for first-trimester or higher-dosage exposure.

120 s who received hydroxychloroquine (200mg tid dosage for 10 days) on a compassionate basis in addition

121 The final normalized dosage for patients who flared and remained on inflixima

122 a CDI mouse model and establish an adequate dosage for treatment.

123 hlight the importance of correct FOXC1/foxc1 dosage for vertebrate development.

124 dine (measured in subjects who completed all dosages for Studies 1 and 2) was elevated at the 12- and

125 A single gastric resident dosage form achieves an AUC equivalent to 7 daily treatm

126 low for packing this gaseous molecule into a dosage form for the goal of "carbon monoxide in a pill."

127 etention requires physical resistance of the dosage form to gastric emptying forces, which are known

128 lung, colon and breast cancer in its liquid dosage form, has been selected to develop injectable nan

129 e development of an effective and controlled dosage form, i.e., in situ nasal gel for brain targeting

130 Most of the 48 NDAs evaluated were for new dosage forms (n = 25 [52.1%]) or new formulations (n = 9

131 llent excipient for formulation of classical dosage forms and advanced drug delivery systems.

132 Additionally, for drug dosage forms containing multiple controlled-release pell

133 itical role in the characterization of solid dosage forms due to its capabilities of chemical identif

134 provide them the potential to simplify drug dosage forms for PIB-containing HCV therapy.

135 The dosage formulation of poorly water-soluble drugs often f

136 this context, challenges associated with the dosage formulation of poorly-water soluble drugs can be

137 t study, the nanoparticle formulation with a dosage frequency of once every 5 days exhibited similar

138 (30.4%), patient refusal (30.3%), incorrect dosage/frequency (8.2%), and patient off-unit (3.4%).

139 adoxically robust to variations in morphogen dosage, given that, by definition, gene expression must

140 Furthermore, in the modified high initial dosage group (17 patients), the initial dose was 10 JAU

141 reached 339.3+/-19.0 JAU in the low initial dosage group and 358.3+/-24.9 JAU in the high initial do

142 ut of 33 (84.8%) patients in the low initial dosage group and in 12 out of 18 (66.7%) patients in the

143 reased 452.9+/-20.6 JAU in the modified high-dosage group at 9 or 10 days.

144 oup and 358.3+/-24.9 JAU in the high initial dosage group at the end of the rush phase, significantly

145 t of 18 (66.7%) patients in the high initial dosage group, on the other hand significantly reduced in

146 of 17 (23.5%) patients in the modified high-dosage group.

147 VE of dosage groups (100% vs 33%) was significantly different

148 eline anemia who received canakinumab at any dosage had significantly less incident anemia than those

149 ulation after seaweed applications at a high dosage (Hd) to the grapevines increased the concentratio

150 length is associated with a >1% reduction in dosage if using the alternative lowest-dose route.

151 emain healthy despite significant X-autosome dosage imbalance.

152 We further evaluated how antibody dosages impacted viral entry into cells expressing viral

153 These results indicated that SLIT dosage in children is same as adults without any concern

154 ck-in model of ALS that best replicates gene dosage in familial ALS (fALS).

155 te exquisite and diverse sensitivity to TBX5 dosage in heterogeneous subsets of iPSC-derived cardiomy

156 Modulating Kdm5c gene dosage in XX female mice to levels that are normally pre

157 trans paired nicking retains target protein dosages in gene-edited cell populations and expands gene

158 at therapeutically relevant efficiencies and dosages in the mouse brain (up to 59% of unsorted cortic

159 Moreover, we characterized MAb dosages in viral-receptor-dependent, Fc-receptor-depende

160 Both in vitro and in vivo, Kdm5c dosage influenced gene expression involved in extracellu

161 ta included patient demographics, infliximab dosage information, additional immunosuppression medicat

162 molecular marker data with or without allele dosage information, such as that from microarray or sequ

163 rdinated dosage responses than do putatively dosage-insensitive gene groups, suggesting that constrai

164 Gene dosage is a key defining factor to understand cancer pat

165 and reducing medical costs as higher opioid dosage is associated with an increased risk of adverse e

166 Optimizing antithymocyte globulin (ATG) dosage is critical, particularly for high-risk kidney tr

167 atterns to variations in the dorsal maternal dosage is still unclear.

168 very system, selection of effective and safe dosage is the key to sparing local therapy.

169 (SCS) treatment, irrespective of duration or dosage, is associated with adverse outcomes for patients

170 Interestingly, increased AG dosage led to similar results.

171 plasma diflunisal levels reached at typical dosage levels.

172 s are significantly less affected by LCA (at dosages < 200 um).

173 rs with serum lithium levels <0.64 mEq/L and dosages <600 mg/day had more reactive newborns without a

174 ction between Ube3a and Mef2 as simultaneous dosage manipulation in different tissues including glia,

175 ur in comparison between single and pairwise dosage manipulations.

176 opod model leads to formulate the "bacterial dosage model" throughout extended phenotypes as the conj

177 we review the significance of the "bacterial dosage model", which connects the expression of the exte

178 ich if not accounted for when determining UV dosage needed for sufficient disinfection may result in

179 nd Colletotrichum gloeosporioides with a MIC dosage of 0.1% (v/v) for both phytopathogens.

180 A dosage of 17 - 25 million MSCs was found to achieve opti

181 sistant were established based on a standard dosage of 6 mg/kg/day.

182 mug/mL was established based on an increased dosage of 8-12 mg/kg/day (>=8 mug/mL-resistant).

183 ation by quantifying students' terrain-based dosage of ambient nitrogen dioxide (NO(2)) during their

184 ular antibody-antigen binding with a tunable dosage of antibodies.

185 ried from a few days to four months, and the dosage of Dex gradually decreased without eliciting sign

186 liver (95.3%) of infected mice after an oral dosage of four daily doses of 1.5 mg/kg.

187 Purpose To evaluate the relationship between dosage of gadobenate dimeglumine and SI change at MRI fo

188 monstrates that an application of a nontoxic dosage of GHz ultrasonic waves [Formula: see text] cause

189 n = 20 men and n = 20 women) and/or a 16-g/d dosage of histidine (Study 2, n = 21 men and n = 19 wome

190 the observation period while using the same dosage of ICS during a certain period of time.

191 Dosage of imprinted genes is crucial for normal developm

192 he early Drosophila embryo is robust to gene dosage of its locally produced regulator, WntD, it is se

193 e studies demonstrate that the sex-dependent dosage of Kdm5c contributes to male/female differences i

194 We identified the genomic dosage of Kdm5c, an X chromosome gene that escapes X chr

195 Neurons are sensitive to changes in the dosage of many genes, especially those regulating synapt

196 module with respect to perturbations to the dosage of maternally-expressed dorsal mRNA.

197 However, the optimal dosage of moxidectin alone and in combination with alben

198 hat tumorigenic capacity is dependent on the dosage of phf7 This study reveals that ectopic PHF7 in f

199 tter/atrial tachycardia absent new/increased dosage of previously failed/intolerant class I/III antia

200 en randomised 1:1 to receive either the same dosage of ranibizumab (0.5 mg) injections pro re nata al

201 matrix, other) were constructed based on the dosage of SNPs and conditional beta values; a lifestyle

202 We predict that, as the dosage of stimulus gradually increases, liver cells from

203 importance of both the genomic location and dosage of sub-clonal events; the pervasive nature of gen

204 a lack of consensus on the optimal route and dosage of TAM administration in vivo.

205 -editing at each gene target despite reduced dosage of target-specific RNP.

206 nderestimates of both the length and reduced dosage of the alternative routes by up to a quarter in c

207 fine transcriptional consequences of reduced dosage of the CHD transcription factor, TBX5, in individ

208 ese goals, investigators used the statin and dosage of their choice and added ezetimibe as needed.

209 ered strains, we show that the relative gene dosage of this variant versus canonical H2A controls the

210 insufficient cells and mice required a lower dosage of VGCC antagonists to block infection.

211 Whether dosage of vitamin D supplementation has a differential e

212 rial to compare the efficacy and safety of 2 dosages of a budesonide orodispersible tablet (BOT) vs p

213 The prescribed dosages of beta-blockers and renin-angiotensin system in

214 Heterogeneity of study designs, dosages of DOACs, and types of P2Y12 inhibitors.

215 ent C. difficile vaccine that contains equal dosages of genetically and chemically detoxified toxins

216 Prescribed dosages of heart failure (HF) therapy in patients with a

217 tailed information on prescription rates and dosages of HF drugs were assessed according to systolic

218 e aimed to determine the tolerance to graded dosages of histidine in a healthy adult population.

219 Healthy adults aged 21-50 y completed graded dosages of histidine supplement (4, 8, and 12 g/d, Study

220 Exposure to low dosages of polyamidoamine dendrimer carbon nanotubes (PA

221 Dosages of Si above 100 mug/ml decreased cell proliferat

222 igated the effects of altering the Sox9 gene dosage on the severity of liver disease in an ALGS mouse

223 n part, by the evolution of gene content and dosage on the sex chromosomes, and are regulated by repr

224 w (0.25%, v v(-1)) and high (0.50%, v v(-1)) dosages on grape and wine phenolic compounds in 2017 and

225 t effects in mESCs depending on its receptor dosage, opening perspectives for balancing self-renewal

226 effectiveness within the different simulated dosage options.

227 These results explain why increasing aspirin dosage or aspirin addition to other drugs may lessen ant

228 conditions of either increased bicoid (bcd) dosage or bcd knockout.

229 ontents of volatile compounds, regardless of dosage or incubation time.

230 er coding regions; these variants affect the dosage or structure of 4.2 genes and account for 4.0-11.

231 herapies, these strategies may lead to lower dosages or numbers of cycles required and, in turn, redu

232 Using these variance estimates in a dosage outlier test (ANEVA-DOT) applied to AE data from

233 Predictable translation dosage over two orders of magnitude in mammalian cell li

234 0.05) and blood urea nitrogen increased with dosage (P = 0.013) and time (P < 0.001) in Study 1 and w

235 Omalizumab dosage per weight alone was strongly associated with pro

236 2) = 28.18; P < .0001), whereas the standard dosage per weight and total IgE level used for asthma wa

237 Higher cumulative steroid dosage (per 10 mg/kg) was associated with increased risk

238 gence of two mechanisms: confinement of Sox9 dosage perturbation to developing facial structures thro

239 ely; 60, 62, and 66% for the same moxidectin dosages plus 400 mg of albendazole, respectively; and 12

240 By analytical solution, we obtain optimal dosage protocols and establish a phase diagram with an e

241 tic target for disorders with reduced SHANK3 dosage, provide a rich resource for studying Shank3 regu

242 posure of ovaries to vinclozolin-at in vitro dosages ranging from 10 to 200 muM and in 3D ex vivo cul

243 ctrolysis times (0.5 min), i.e., high charge dosage rates (1200 C/L/min), ACAIE consistently outperfo

244 Thus, OCS dosage reduction is desirable.

245 parable to mepolizumab and dupilumab for OCS dosage reduction, OCS elimination, and annual exacerbati

246 Randomized controlled trials with optimal dosage regimens are warranted.

247 Different dosage regimens of hydroxychloroquine are used to manage

248 del was used to determine optimal antibiotic dosage regimens to treat the host to maximise survival w

249 tleneck separates pre-HE from HE, with RUNX1 dosage regulating the efficiency of the pre-HE to HE tra

250 imprinting is mainly associated with genome dosage regulation or allocation of resources.

251 ailable, such as low toxicity, low-effective dosage required, and a high degree of manipulability.

252 ith the biopesticide AfMNPV baculovirus in a dosage response assay.

253 meiosis and regulate chromosomal and genomic dosage response.

254 nce is governed by gene dosage and that gene dosage responses are consistent for interacting genes in

255 onse to genome doubling, and individual gene dosage responses are highly variable in all three access

256 nduction, to estimate transcriptome size and dosage responses immediately following ploidy change.

257 oteins) exhibit smaller and more coordinated dosage responses than do putatively dosage-insensitive g

258 Gene dosage responses, however, have rarely been quantified,

259 unction variation, even when compared to the dosage sensitive transcription factors, and we identify

260 We identify dosage-sensitive CHD8 transcriptional targets, sites of

261 e is the existence of disruptive variants in dosage-sensitive disease genes, even in apparently healt

262 y delays progenitor mitotic progression in a dosage-sensitive fashion, with 40% of homozygous progeni

263 mplexities of modulating the expression of a dosage-sensitive gene but also highlights the critical i

264 this study, we focus on Ataxin-1 (ATXN1), a dosage-sensitive gene involved in the neurodegenerative

265 housekeeping genes having few contacts, and dosage-sensitive genes being more connected to enhancer

266 Our results demonstrate that dosage-sensitive genes have evolved a robustness to the

267 Identifying modifiers of dosage-sensitive genes involved in neurodegenerative dis

268 nt on synonymous variation, we discover that dosage-sensitive genes, DNA-damage-response genes, and c

269 iquitously expressed, functionally coherent, dosage-sensitive genes, or have evolved male-specific fu

270 this approach for identifying regulators of dosage-sensitive genes.

271 Our results establish Sox9 as a dosage-sensitive modifier of Jag1(+/-) liver phenotypes

272 nisms by which the transcriptional output of dosage-sensitive molecules is established or modulated b

273 We show that the Clp machinery regulates dosage-sensitive proteins such as the small heat shock p

274 driven sex biases in expression of critical, dosage-sensitive regulatory genes.

275 CHD8 has a dosage-sensitive role in ASD, but when and how it become

276 n be characterized by a parameter, phenotype dosage sensitivity (PDS), which quantifies the relations

277 elucidate in vivo due to differences in gene dosage sensitivity between mice and humans.

278 vidence to support the GWAS studies that the dosage sensitivity intolerance of VIPR2 is disease causa

279 Finally, we infer the dosage sensitivity of genes and noncoding elements, and

280 of OIT and IgE-mediated disease, omalizumab dosages should be adjusted for body weight alone, indepe

281 Genetically reducing beta-catenin dosage significantly reverses the ZNRF3-deficient phenot

282 RUTI vaccine and isoniazid, according to the dosage strategy described in the clinical trial design.

283 of oral immunotherapy (OIT), but the optimal dosage strategy is unknown.

284 d address gaps related to patient selection, dosage, team culture, and expertise.

285 Opioid prescription, dosage thresholds (morphine milligram equivalents [MME]

286 show the unconventional association of LKB1 dosage to prostate tumorigenesis.

287 there is selection on gene copy number (gene dosage) to preserve the stoichiometric balance among int

288 events by age, duration of illness, and DAT dosage using bivariate comparisons.

289 Finally, we examined the impact of gene dosage variation triggered by a CNV spanning the SEC10 g

290 Recommended dosages vary widely, and first- and second-line agents a

291 In 36%, trimethoprim-sulfamethoxazole dosage was elevated by current ESRD guidelines.

292 Moderate-intensity dosage was found to decrease the risk of ECC (OR, 0.48;

293 ydroxycinnamic acids, whereas the effects of dosage were mostly negligible.

294 Both cariprazine dosages were associated with lower CGI-S scores compared

295 Both dosages were equally effective and well tolerated.

296 ftazidime/gentamicin/meropenem) at different dosages were explored.

297 Antipsychotic dosages were not correlated with ERG parameters.

298 xposures so, for future studies, rivaroxaban dosages were revised for these weight categories, to mat

299 specified mechanism of action, kinetics, and dosage, which we show is accurate when checked against d

300 suggests highly polygenic properties of gene dosage with respect to autism risk and IQ loss.