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1 agent (ie, CRO 250 mg, intramuscular single dose).
2 ed dosing than among those receiving a fixed dose.
3 Cs at D30, with no increase after the second dose.
4 nsitization success or successfully consumed dose.
5 rnal capsule, not explained by antipsychotic dose.
6 starting concomitantly with the first taxane dose.
7 e points (95% CI, -47 to -16) for the 100-mg dose.
8 rate as effectively as the standard clinical dose.
9 stence of functional B cells after the third dose.
10 in part B were given the recommended phase 2 dose.
11 r of the Akt-beta-catenin interaction at low doses.
12 generally being well tolerated at prescribed doses.
13 by intravenous heroin at low, human-relevant doses.
14 IT therapy was given for a total of 21 to 26 doses.
15 hibiting adverse side effects at therapeutic doses.
16 ine and lower but significant VE with 1 or 2 doses.
17 each dose group between weight-band and flat-dosing.
18 median AUC0-24h compared to the weight-band dosing.
19 onged control of tumors through intermittent dosing.
20 Blood samples were collected for 96 h after dosing.
21 effects of naloxone-methiodide at a very low dose (0.2 mg/kg; at which naloxone was undetectable in b
23 age points (95% CI, -40 to -5) for the 40-mg dose, -19 percentage points (95% CI, -35 to 2) for the 6
25 ), and mean FIA [+/-SD](%) from the baseline dose [23.3 (10.9)] was greater than that from the consec
27 ence interval [CI], -18 to 27) for the 20-mg dose, -25 percentage points (95% CI, -40 to -5) for the
29 eated with definitive chemoradiation (median dose 50.4 Gy) followed by resection within 4 months.
31 nously over 2 h, l-folinic acid (175 mg flat dose administered intravenously over 2 h) or d,l-folinic
32 y over 2 h) or d,l-folinic acid (350 mg flat dose administered intravenously over 2 h), and fluoroura
34 osing based on a hemoglobin-based, titration-dose algorithm in such patients might reduce risks assoc
40 g correlation between the lipopolysaccharide dose and (64)Cu-LLP2A uptake, as quantified by in vivo P
41 of CD8(+) T cell Ag recognition, in which Ag dose and affinity do not provide any additional response
42 tion with lanadelumab started from the first dose and continued throughout the entire study period.
45 st+ and Pvalb+ subtypes in the mPFC produced dose and time-dependent antidepressant effects in the fo
47 nstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r = -.67,
49 might reduce risks associated with high ESA doses and decrease the cumulative exposure-while reducin
50 otensin II reduced catecholamine vasopressor doses and had an apparent effect in reducing endogenous
51 voir potential of well over a year at mg/day dosing and may not require cold chain storage for global
52 tage points (95% CI, -35 to 2) for the 60-mg dose, and -33 percentage points (95% CI, -47 to -16) for
53 d vaccination, particularly with the highest dose, and three participants (21%) in the 250-mug dose g
54 s demonstrated that chemoprophylaxis, or low-dose anticoagulation, prevents VTE in selected medical i
57 porating model error that shifts the TGFbeta doses associated with the state transitions and reproduc
58 intravenously every 3 weeks (8 mg/kg loading dose at first cycle, and 6 mg/kg thereafter) for 18 dose
60 s greater than that from the consecutive day dose (at 24 h) [20.1 (10.4); P = 0.042] but did not diff
63 Whether using a low fixed ESA dose versus dosing based on a hemoglobin-based, titration-dose algor
64 ot have diuretics, 2195 (33.1%) had diuretic doses between 1 and 40 mg/day, and 1085 (16.4%) had diur
66 ine, after pulmonary embolism and after each dose by biventricular pressure-volume loops, invasive pr
69 -CD20 therapy), were not candidates for high-dose chemotherapy and subsequent autologous stem-cell tr
70 lls but began to decline after 3 to 6 weekly doses, coincident with the development of antidrug antib
71 dolutegravir 50 mg; or once-daily oral fixed-dose combination of tenofovir disoproxil fumarate 300 mg
72 e randomly assigned to once-daily oral fixed-dose combination tenofovir alafenamide 25 mg and emtrici
73 al dolutegravir 50 mg; once-daily oral fixed-dose combination tenofovir disoproxil fumarate 300 mg an
76 nts completed 4 cycles of paclitaxel without dose delay, the regimen would be considered feasible.
80 that rhbeta-gal uptake by the fibroblasts is dose-dependent and saturable and can be competitively in
83 annel blocker of HCNs-for 24 h resulted in a dose-dependent higher HRV and lower heart rate at 5 days
84 ounds in the cochlea, rather cisplatin had a dose-dependent impact on cochlear clock rhythms only aft
85 nsitive male NSCLC cell lines demonstrated a dose-dependent induction of linc-SPRY3-2/3/4 following i
86 le administration of (212)Pb-L2 demonstrated dose-dependent inhibition of tumor growth in the PSMA(+)
87 bladder epithelial progenitor cell line in a dose-dependent manner, achieving far higher efficiency a
88 rmone levels in both dams and offspring in a dose-dependent manner, but did not change TSH levels, we
89 xpansion and restorative division rates in a dose-dependent manner, leading to tumorous overprolifera
98 or, immediately after the extinction session dose-dependently impaired the consolidation of fear exti
108 ere locoregional control, local control with dose-escalated RT, pattern of failure, and adverse effec
109 assigned to receive intravenous haloperidol dose escalation at 2 mg every 4 h, neuroleptic rotation
110 ongoing placebo-controlled, observer-blinded dose-escalation study (ClinicalTrials.gov identifier NCT
114 s to examine the effect of low- and moderate-dose fiber-containing snack bars, comprising mainly chic
116 At the dose of 10 mg/kg (600 mg for flat-dosing), flat-dosing resulted in higher median AUC0-24h
117 Plausible upper-bound, lifetime radiation dose for each boar was estimated from radioactivity leve
119 immunogenicity trial of qNIV (in 5 different doses/formulations) in healthy adults aged >=65 years.
121 e of any of the eight animals in the 100-mug dose group by day 2 after challenge, and limited inflamm
122 and three participants (21%) in the 250-mug dose group reported one or more severe adverse events.
125 USA), with refractory agitation, despite low-dose haloperidol, were randomly assigned to receive intr
127 e on day 3 (10.5 +/- 4.1 percentage injected dose [%ID]/g vs. 3.8 +/- 0.9 %ID/g, P < 0.001) and on da
128 contrast, alveolospheres pretreated with low-dose IFNs show a reduction in viral replication, suggest
129 ter) for 18 doses or weekly (4 mg/kg loading dose in the first week, and 2 mg/kg thereafter) for 9 we
132 blind, comparator-controlled (trivalent high-dose inactivated influenza vaccine [IIV3-HD], or quadriv
133 risk of CVDs associated with glucocorticoid dose intake even at lower doses (<5 mg) in 6 immune-medi
134 val (RFS) and overall survival (OS) for high-dose interferon alfa (HDI) and ipilimumab at 10 mg/kg (i
136 soporous SNPs 466.0 +/- 86.0 nm) upon single dose intravenous administration to female and male BALB/
138 his breakpoint presumes that AZI (1-g single dose) is used in an approved regimen that includes an ad
139 mages from SDCT is high and independent from dose, kernel, and denoising settings; however, shows a d
146 n chemical agents used as therapeutics, "the dose makes the poison," it is now realized that this apt
147 d treatments, number of IAC injections, drug dose, mean injection time, injection method (pulsatile v
148 e majority of the patients had received high-dose melphalan and stem cell transplantation and/or trea
150 n AD was comparable to that of radiobiologic dose metrics that involve more complex calculations.
151 oroalkyl sulfonates (PFSAs) were enriched in dosed mouse serum, suggesting in vivo transformation of
154 p=0.351 in the patients who had received <15 doses (n=34), and -0.0135+/-0.1332 (not significantly di
157 aimed to prospectively determine the lowest dose of (64)Cu-DOTATATE that facilitates diagnostic-qual
159 nuous 28-day schedule, to adults mostly at a dose of 100 mg twice daily, and to paediatric patients m
160 aily, and to paediatric patients mostly at a dose of 100 mg/m(2) (maximum of 100 mg) twice daily.
161 ovides high-quality and accurate images at a dose of 148 MBq (4.0 mCi) for the detection of somatosta
164 iral classes to add either fostemsavir (at a dose of 600 mg twice daily) or placebo to their failing
165 f Intralipid with half the standard clinical dose of Abraxane reduces the tumor growth rate as effect
166 n all participants who received at least one dose of any study drug, regardless of whether it was the
167 eport that all infants given either a single dose of bNAbs at 30 h, or a 21-day triple-drug ART regim
168 In patients with advanced CLL, a 5 x 10(8) dose of CART-19 may be more effective than 5 x 10(7) CAR
170 no differences in outcomes between standard dose of epinephrine and vasopressin alone or in combinat
171 on one randomized controlled trial, standard dose of epinephrine improved overall survival but not ne
172 us iron was administered as a single 1000 mg dose of ferric carboxymaltose in 100 mL normal saline, a
173 correlate significantly with the accumulated dose of gadoterate meglumine (P=0.9064; rho=-0.0164 [95%
174 D, primary outcome) is the FDA/EMEA approved dose of gemcitabine-nab-paclitaxel along-with ATRA (45 m
175 uration treatment with a clinically relevant dose of GS-9688 is well tolerated and can induce a susta
177 e 3 treatments in a random order: bolus 30-g dose of LNS (Bolus); 3 x 10-g doses of LNS (Divided); an
179 ith the histological analysis reveals a safe dose of microcapsules (20 x 10(6)), which has not lead t
180 vivo, this can be accomplished with a single dose of p53 inhibitor at the commencement of BRAF/MEK in
181 1 month later by saline placebo or a single dose of PCV13 followed 1 month later by 23-valent polysa
182 e were randomized to receive either a single dose of PCV20 followed 1 month later by saline placebo o
184 743 adults were enrolled; 741 received >=1 dose of study drug (DTG/3TC, N = 369; TAF-based regimen,
185 n all participants who received at least one dose of study drug in terms of treatment-emergent advers
187 All enrolled patients received at least one dose of study treatment and thus were evaluable for 12-w
191 to receive either BCG, followed by a booster dose of tetanus-diphtheria-pertussis inactivated polio v
193 tudy, we investigated whether a single 10 mg dose of the GABA(B) agonist baclofen impaired motor sequ
197 e responsive to levodopa, and were on stable doses of anti-parkinsonian medication were eligible.
198 In an open-label titration phase, increasing doses of apomorphine sublingual film (10-35 mg) were adm
200 The present findings also revealed that high doses of BrdU lead to the activation of apoptotic cellul
202 did not reveal an association, but reported doses of corticosteroids in included studies were high (
203 ses of everolimus and nonsignificantly lower doses of cyclosporin A, resulting in significantly lower
205 inistration, and again on Day 10 after daily doses of either 4 mg (Cohorts 1 and 2), or 1 mg (Cohort
206 ion group received significantly lower daily doses of everolimus and nonsignificantly lower doses of
208 ficant VE against vaccine-type CIN2+ after 3 doses of HPV vaccine and lower but significant VE with 1
210 ants were exposed to three different blinded doses of intranasally administered nicotine (0, 0.5, 1.0
211 er: bolus 30-g dose of LNS (Bolus); 3 x 10-g doses of LNS (Divided); and no LNS (Control), with contr
214 ICU patients who were given moderate-to-high doses of opioids and expected to remain alive and ventil
216 White rabbits were administered 3 sequential doses of the full-length gB protein with an MF59-like sq
218 urve" with increasing cAMP production at low doses of TSH and decreased cAMP production at high doses
221 ithelium, a valuable activity at therapeutic doses on a range of clinical pathogens, mediated by ener
223 first cycle, and 6 mg/kg thereafter) for 18 doses or weekly (4 mg/kg loading dose in the first week,
224 nal regimen (CsA CE 4 times daily [QID, high-dose] or CsA CE twice daily [BID, low-dose] + vehicle BI
226 ombination (CSR), while decreasing at higher doses over a broad physiological range, AID and Blimp1 e
227 f 4-6 reduction in imaging time (or injected dose) over the mCT Flow when using the ALROC metric for
230 ation, providing 33.90 +/- 9.06% of injected dose per gram of brain tissue (%ID/g) in the cortex and
231 +/- 0.2 and 3.04 +/- 0.3 percentage injected dose per gram, respectively) indicating that (18)F-FAC c
233 S; gemcitabine plus dacarbazine in LMS; high-dose prolonged-infusion ifosfamide in SS; etoposide plus
235 risk of, and associations with, SAE and high-dose radiation exposure using large-scale registry data.
238 ed serious adverse effects were found in the dose-ranging study in rats administered single- or two-d
239 andomized, double-blind, placebo-controlled, dose-ranging trial involving 286 patients with establish
242 n and developed a therapeutic regimen of low-dose recombinant human interleukin-2 (IL-2) combined wit
243 ed noninferiority of once-daily 60 mg (30 mg dose-reduced) edoxaban compared with warfarin for preven
246 ng study in rats administered single- or two-dose regimens of S-2P combined with CpG 1018 alone or Cp
247 proximately 40% of patients in both exercise dosing regimens were classified as VO(2)peak responders
253 HR activation exhibits an "inverted U-shaped dose-response curve" with increasing cAMP production at
255 0a, Or22a and Or35a) showed a shift in their dose-response curves when Orco was co-integrated, reflec
256 ta sets combined showed significant negative dose-response for the accumbens, caudate, pallidum, puta
258 e of 10 mg/kg (600 mg for flat-dosing), flat-dosing resulted in higher median AUC0-24h compared to th
259 tolerated dose (MTD) and recommended phase 2 dose (RP2D, primary outcome) is the FDA/EMEA approved do
260 (1) long-term immunogenicity of an initial 2-dose RZV schedule by following-up adults vaccinated at >
263 h the same or a different statin (or a lower dose) seem to be favorable options for improving statin
264 rs of age), who were randomized to receive 2 doses-separated by 21 days-of 10 mug, 30 mug or 100 mug
265 narios), EPA's Stochastic Human Exposure and Dose Simulation (SHEDS)-Multimedia/Integrated Exposure U
267 ome end points included SER-287 engraftment (dose species detected in stool after but not before SER-
269 omized, placebo-controlled, single ascending dose study consisting of 3 cohorts (40, 80, 120 mg MMV39
273 ibit CD4 and CD8 T cell proliferation at the doses that are not related to increased cell death.
274 In timeframes beginning 30 days post-second dose, the primary endpoint (overall vaccine efficacy) wa
275 mence subcutaneous dupilumab (600 mg loading dose, then 300 mg once weekly for 15 weeks [n = 30], or
281 ention Trials Network (HPTN) 067/Alternative Dosing to Augment PrEP Pill Taking (ADAPT) Study evaluat
282 ng antibodies on day 43 were 0.7-fold (1-mug dose) to 3.5-fold (50-mug dose) those of the recovered i
284 ematologic toxicity resulted in more reduced dosing/treatment discontinuation in arm B vs arm C.
285 HRs for type-specific CVDs and <5.0-mg daily dose use were: 1.69 (95% CI 1.54-1.85) for atrial fibril
288 , high-dose] or CsA CE twice daily [BID, low-dose] + vehicle BID) and vehicle patients were allocated
292 a-secreting T-cells after a ChAd155-RSV high dose was 108.3/106 PBMCs at D30, with no increase after
298 odds ratios for vaccination with 1, 2, and 3 doses were 0.53 (95% confidence interval (CI): 0.37, 0.7
300 n 32 (91%) of 35 participants after a single dose when measured in MNA(80) and in 35 (100%) participa