ライフサイエンスコーパス: dosing

1 able weight loss (up to 20 weeks post end of dosing).

2 05 to continuous dosing, 101 to intermittent dosing).

3 morning may be preferable to consecutive day dosing.

4 A added to pre-formed nanoparticles prior to dosing.

5 emicals in the fetus resulting from maternal dosing.

6 is needed, combined with optimisation of OAT dosing.

7 regimen was a desirable alternative to daily dosing.

8 ut was below assay sensitivity 6 hours after dosing.

9 n exposure after weight-band dosing and flat-dosing.

10 each dose group between weight-band and flat-dosing.

11 minimize transfusions, with less cumulative dosing.

12 ein (LDL) cholesterol levels with infrequent dosing.

13 ht-band dosing and dose 600-2400 mg for flat-dosing.

14 al phage therapy while enabling control over dosing.

15 onged control of tumors through intermittent dosing.

16 onsive host genes responded uniformly to VOR dosing.

17 ble for achieving accurate, preclinical drug dosing.

18 Blood samples were collected for 96 h after dosing.

19 al cerebral blood flow during two hours post-dosing.

20 low weight, which can be overcome with flat dosing.

21 s who completed at least 8 weeks of assigned dosing.

22 proaches, cannula design, vector volumes and dosing.

23 participants and was cleared 4-8 days after dosing.

24 he same effect could not be achieved by oral dosing.

25 timated half-life supporting once-daily (QD) dosing.

26 sed every 8 weeks with that of every 4 weeks dosing.

27 ymphoma xenograft mouse model following oral dosing.

28 linical parameters, including LVEF, to guide dosing.

29 o a human half-life suitable for once-weekly dosing.

30 cted for weight-band dosing compared to flat-dosing.

31 median AUC0-24h compared to the weight-band dosing.

32 occurring at concentrations relevant to oral dosing.

33 om intermittent compared with continuous TKI dosing.

34 months of 87.2% (95% CI, 57.2-96.7) with QD dosing.

35 g, water-accommodated fractions, and passive dosing.

36 oid therapeutics are realized after extended dosing.

37 (CBCA) were detected in all cattle after IH dosing.

38 e potent pathway inhibition compared with QD dosing.

39 ld density maintained by adaptive antibiotic dosing.

40 1:1 to the two study arms (105 to continuous dosing, 101 to intermittent dosing).

41 mmune responses can be induced by additional dosing 10Y after the initial 2-dose course.

42 By day 30 after initial dosing, 17/23 were recovered, 2/23 were still hospitaliz

43 f OIT (start 4.0, 3.2-5, P = .004; end of up-dosing 2.9, 1.9-4.7, P = .04; follow-up 2.2, 1.6-3.6, P

44 IT (median (IQR); 4.8, 3.8-5.7) to end of up-dosing (3.9, 3-5.2) (P < .001).

45 periment confirmed the inhibitory effects of dosing a sample of wood materials with varying concentra

46 a computable phenotype in ADAPTABLE (Aspirin Dosing: a Patient-Centric Trial Assessing Benefits and L

47 Dosing adherence remains a crucial factor determining th

48 strate real-world effectiveness of 2p+1b PCV dosing against vaccine-serotype colonization.

49 After multiple dosing, ALDC1 significantly delayed the tumor growth com

50 age-adjusted and weight-adjusted dabigatran dosing algorithm was appropriate in children aged birth

51 e appropriateness of a paediatric dabigatran dosing algorithm, and the efficacy and safety of dabigat

52 estigated at various doses, frequencies, and dosing algorithms, but clarity on the optimal dosing app

53 months of 91.5% (95% CI, 70.0-97.8) with BID dosing and an ORR of 79.2% (95% CI, 57.9-92.9) and an es

54 Oral dosing and brain activity of 5b were established in nont

55 effects were associated with reduced opioid dosing and changes in self-referential processing.

56 eatment then slowly decreased, regardless of dosing and delivery methods.

57 cs model at dose 10-40 mg/kg for weight-band dosing and dose 600-2400 mg for flat-dosing.

58 vant indicators of quality of care including dosing and examinations, and that only 9 countries were

59 ng DAA system (LA-DAAS) capable of prolonged dosing and explored its cost-effectiveness.

60 ity of rifampicin exposure after weight-band dosing and flat-dosing.

61 hort (n = 9) received single or fractionated dosing and had manageable toxicity with a 33% complete r

62 mic effects were assessed on the last day of dosing and included evaluation of brain activation patte

63 voir potential of well over a year at mg/day dosing and may not require cold chain storage for global

64 lood concentration would enable personalized dosing and monitoring of the analgesic as well as quick

65 codynamics suggest a reevaluation of current dosing and monitoring recommendations.

66 ncomycin consensus guidelines for vancomycin dosing and monitoring.

67 safety signal, allowing simplified practical dosing and rapid access to dolutegravir.

68 es hinders efforts to optimize antimicrobial dosing and shorten TB treatments(2).

69 esults strongly suggest that, at appropriate dosing and therapeutic period, chronic bryostatin-1 may

70 from agricultural contamination to incorrect dosing and usage of poor-quality medicines.

71 withdrawn from part 2 (80 mg cohort) before dosing and was not included in analyses.

72 an AUC0-24 h of all dose groups between flat-dosing and weight-band dosing were considered low (< 20%

73 anut, sesame, or tree nuts, at the end of up-dosing, and after 6 months of follow-up.

74 iron absorption compared with alternate day dosing, and dosing on alternate days or every third day

75 ACi can vary, particularly with intermittent dosing, and information is lacking on the relationship b

76 Important phase 2 results of every 8 weeks dosing, and supportive modelling, underpin further evalu

77 osing algorithms, but clarity on the optimal dosing approach is lacking.Objectives: To characterize r

78 nitoring would provide a more individualized dosing approach.

79 antimicrobial concentrations using standard dosing approaches.

80 Stretching was matched to exercise dosing arms on the basis of location, frequency, duratio

81 ere randomized to receive controlled TDF/FTC dosing as (1) "perfect" adherence (daily); (2) "moderate

82 manuscript establishes inadequate enoxaparin dosing as a plausible mechanism for breakthrough VTE in

83 1) and higher 24-hour cumulative vasopressor dosing as norepinephrine equivalent (beta coefficient, 0

84 and FX (85 and 101 U/dL, respectively, after dosing at 100 U/kg).

85 xposure and low systemic exposure after oral dosing at 25 mg/kg in mouse.

86 Repeat dosing at months 3, 6, and 9 was done in the absence of

87 ts of administering clinically relevant drug dosing at single-cell resolution in vivo.

88 Whether using a low fixed ESA dose versus dosing based on a hemoglobin-based, titration-dose algor

89 for using weight-band dosing instead of flat-dosing becomes questionable.

90 l sorafenib concentrations after therapeutic dosing, but the association between a decrease in tumor

91 rophage compartment with extended antibiotic dosing can achieve pre-exposure prophylaxis in a model o

92 sed therapeutics of solid tumors, but proper dosing can improve the tissue penetration and thus thera

93 dults with r/r ALL received CTL019 in 1 of 3 dosing cohorts.

94 hemistry analysis were observed following IH dosing compared to baseline values.

95 nt variability was predicted for weight-band dosing compared to flat-dosing.

96 subsequent time points through 4 weeks post dosing compared with the placebo group (P < .05).

97 upancy attained by BID dosing relative to QD dosing compounded over time to augment downstream biolog

98 Simulations were performed under various dosing conditions, including current weight-based method

99 nt regimens, the reader is advised to follow dosing, contraindications and drug-drug interactions bas

100 following supervised inhaled corticosteroid dosing could indicate previous poor adherence.

101 s the safety of siltuximab, assessed at each dosing cycle.

102 Whether effects of daily or weekly dosing differ requires further study.

103 V(donor)/V(medium) > 0.1 L/L) of the passive dosing donor in order to ensure rapid mass transfer and

104 od and Drug Administration approval of adult dosing down to 20 kg.

105 ve BTK inhibitor that allows for twice-daily dosing due to its selectivity.

106 requires greater understanding of the daily dosing duration that is needed to protect the person aft

107 ed Argonaute 2 protein complexes weeks after dosing, enabling continuous RNAi activity over time.

108 ong-acting every 8 weeks was non-inferior to dosing every 4 weeks (HIV-1 RNA >=50 copies per mL; 2% v

109 rate or blood pressure, confirmed comparable dosing exposure across groups.

110 At the dose of 10 mg/kg (600 mg for flat-dosing), flat-dosing resulted in higher median AUC0-24h

111 s and mortality in order to identify optimal dosing for tuberculous meningitis.

112 nstituting a simple and easy-to-use reaction-dosing form.

113 t the need to carefully titrate the dose and dosing frequency of beta-Gal augmentation therapy for GM

114 e used to limit adverse side effects, reduce dosing frequency, and potentially improve patient compli

115 The safety profile was similar between dosing groups, with 844 (81%) of 1045 participants havin

116 nformed the WHO 2019 dolutegravir paediatric dosing guidelines and have led to US Food and Drug Admin

117 erythropoiesis stimulating agent (ESA) drug dosing guidelines or without consideration of inflammati

118 r infection, or fatal infection, but IV iron dosing had no effect on these outcomes.

119 Study limitations include heterogeneity in dosing, heterogeneity in GDM diagnostic criteria, and fe

120 At therapeutically relevant dosing, hMGL-4.0 reduces serum l-Met levels to >75% for

121 stdose) increased 2- to 3-fold with repeated dosing in an approximately dose-proportional manner, rea

122 in the ODYSSEY-trial to evaluate simplified dosing in children with HIV.

123 n models reported here can inform crolibulin dosing in future clinical studies of crolibulin combined

124 ve bleeding and then guide individualized FC dosing in high-risk patients and (2) determining the dos

125 Conclusion: Simultaneous HDACIs and AI dosing in patients with cancer resistant to AI alone sho

126 onic kidney disease, supporting conventional dosing in patients with CrCl 25 to 30 mL/min.

127 acokinetics (PK) profile consistent with bid dosing in patients.

128 n alternative parenteral route of esketamine dosing in patients.

129 Upon oral dosing in rats, CAGE increased peak blood concentrations

130 pared to in vivo performance, following oral dosing in rats.

131 ce data were generated following intravenous dosing in rats/NHPs and compared to the human clearance

132 l insulin delivery should offer both precise dosing in response to real-time blood glucose levels as

133 al iron absorption (FIA), alternate day iron dosing in the morning may be preferable to consecutive d

134 Early treatment and frequent dosing in the real-world setting may be the key to achie

135 ety profile, making it amenable to long-term dosing in these patients.

136 underpin further evaluation of every 8 weeks dosing in this trial, which has the potential to offer g

137 The weight-band dosing in tuberculosis treatment regimen has been implem

138 mine (8 g, -9 to 26), although more frequent dosing increased the antimalarial effect (31 g, 3 to 60)

139 ty and biodistribution assessments on repeat dosing indicated that KB105 was well-tolerated and restr

140 Dosing information now includes the option of a 5-mg dos

141 hermore, the rationale for using weight-band dosing instead of flat-dosing becomes questionable.

142 Increasing vasopressor dosing intensity during the first 24 hours after septic

143 The median vasopressor dosing intensity during the first 24 hours of shock onse

144 etermine the association between vasopressor dosing intensity during the first 6 hours and first 24 h

145 determine whether the effect of vasopressor dosing intensity varies by dosing titration pattern.

146 determine whether the effect of vasopressor dosing intensity varies by fluid resuscitation volume; a

147 od, every 10 mug/min increase in vasopressor dosing intensity was associated with an increased risk o

148 In the first 6 hours, increasing vasopressor dosing intensity was associated with increased odds rati

149 Vasopressor dosing intensity was defined as the total vasopressor do

150 elvitegravir concentration at the end of the dosing interval (Ctrough) was reduced by 77%, with 85% o

151 Optimal dosing interval for maximal CRT reduction may be less th

152 zumab, 55.6% and 51.0% maintained a q12-week dosing interval immediately after the loading phase unti

153 anti-VEGF treatment duration and therefore, dosing interval needs to be optimized in the cohort of s

154 n can be markedly improved by shortening the dosing interval to 12 hours, with no improvement with fu

155 were subsequently challenged with a q12-week dosing interval, and the outcomes provided key informati

156 26%) experience an SMH while having a 4-week dosing interval.

157 The follow-up was 6 months with a monthly dosing interval.

158 By year 4, 36.7% of eyes had <=8-week dosing intervals (q8w) and 21.2% had >=12-week dosing in

159 The reduction in dosing intervals may be a consequence of intensification

160 The advantages of these agents include long dosing intervals of up to 6 months and the potential to

161 oes not seem to be associated with prolonged dosing intervals or recent interval extension, and a lar

162 sing intervals (q8w) and 21.2% had >=12-week dosing intervals.

163 form of disease, indicating that sufficient dosing is critical.

164 The need for individualized dosing is supported by the finding that a 4-fold variati

165 the field by (i) showing accelerated passive dosing kinetics for 68 cracked gas oil constituents with

166 nding on its intracellular concentration and dosing kinetics, including cell death.

167 simulations showed that current weight-based dosing leads to lower exposures in individuals with low

168 on the specific agents used as well as their dosing levels and schedule.

169 nificant differences were observed for the 3 dosing levels when using the averaged reader data (all P

170 n treatment discontinuation, nondaily statin dosing lowered total cholesterol and LDL-C levels.

171 BID dosing maintained higher BTK occupancy and achieved more

172 standardized approach with patient-specific dosing may reduce excessive opioid dispensing.

173 ion-free survival compared with intermittent dosing (median 9.0 months versus 5.5 months, P = 0.064,

174 g the law of mass action, utilizing a double-dosing method ensuring a constant compound concentration

175 12% of women, suggesting that more frequent dosing might be needed.

176 Dosing NaOCl (55 muM) consistently removed As to <10 mug

177 re the first reports of sustained parent TAF dosing observed in mouse and TFV-DP in mouse PBMC.

178 travenous infusion), precluding the feasible dosing of antibody combinations via this route.

179 election, choice of therapy, and appropriate dosing of anticoagulant and antiplatelet agents, in seco

180 ere administered intermittent subtherapeutic dosing of benzylpenicillin, the strain with a Pro601Leu

181 domized to either continuous or intermittent dosing of both drugs on a 3-week-off, 5-week-on schedule

182 Intramuscular dosing of ChAd-SARS-CoV-2-S induces robust systemic humo

183 Fractionated dosing of CTL019 with intrapatient dose modification opt

184 olled in a 4-week study of directly observed dosing of daily oral co-formulated emtricitabine and ten

185 h 43 subjects assigned to receive once daily dosing of either placebo (n = 21) or JNJ-42165279 (100 m

186 todynamic therapy, topical dorzolamide, oral dosing of eplerenone or acetazolamide, or some combinati

187 Intraoperative, individualized dosing of FC appears feasible.

188 course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortison

189 virus-specific T cell levels might optimize dosing of immunosuppressants.

190 optimize the current treatment selection and dosing of immunotherapy.

191 In a mouse PK/PD model, oral dosing of lead compound 2 demonstrated dose-dependent in

192 This study aims to establish dosing of nevirapine for very early treatment of HIV-exp

193 Oral dosing of PRCL-02 was well tolerated and resulted in sup

194 affirming hormones and on directly observed dosing of PrEP have not been studied.

195 Weekly ICV dosing of rhbeta-gal for 8 weeks substantially reduced b

196 -negative patients.Conclusions: Weight-based dosing of rifapentine should be removed from clinical gu

197 ated by vancomycin preconditioning and daily dosing of SER-287.

198 g a phase shift, and we aim to determine the dosing of such molecules with a model-based control stra

199 r suppression equivalent to a month of daily dosing of talazoparib.

200 NCT02196181) evaluating whether intermittent dosing of the BRAF inhibitor dabrafenib and the MEK inhi

201 vity on Days 4 to 7 after the repeated daily dosing of the drug.

202 ational day (GD)6 and continuing with direct dosing of the pups after birth.

203 the placebo response and examine the optimal dosing of TMS for adolescents with TRD.

204 Likewise, IV dosing of TXB2-hFc fused with neurotensin (TXB2-hFc-NT)

205 tion compared with alternate day dosing, and dosing on alternate days or every third day does not inc

206 and afternoon doses are comparably absorbed, dosing on consecutive days increases PHep and modestly d

207 toxicity, variable efficacy, and unsuitable dosing options.

208 These results may lead to nonintuitive dosing or timing treatment schedules to optimize synergi

209 , 2.18 [95% CI, 1.01-4.70]), and twice-daily dosing (OR, 2.81 [95% CI, 1.47-5.36]) were associated wi

210 Included studies were evaluated for dosing, outcomes, and adverse effects of ketamine.

211 00 mg.d(-1) for 5 d, then tapered with lower dosing over 3 d.

212 e potential to enable better optimization of dosing owing to the high precision capabilities availabl

213 nts were enrolled in one of five consecutive dosing panels, receiving a single oral dose of islatravi

214 fected mice in both prophylactic and delayed dosing paradigms.

215 care bundles (e.g. genotype-guided warfarin dosing, patient's self-testing [PST] or patient's self-m

216 en) and nonadherence (<90% adherent) between dosing patterns.

217 Despite standard weight-based dosing, peak plasma concentrations of first-line drugs w

218 se-proportional and sustained throughout the dosing period for all patients (up to 15 months).

219 quently a 2-fold accumulation over the 5-day dosing period.

220 virus-mediated GT, paradigms of delivery and dosing, potential risks and highlights ongoing research

221 to predict patients at greater risk of food dosing reactions subsequent to weaning.

222 ind omeprazole is often administered outside dosing recommendations, and both drugs are frequently ad

223 s compared with a paediatric oral dabigatran dosing regimen (an age-adjusted and weight-adjusted nomo

224 ned by drug (ranibizumab or bevacizumab) and dosing regimen (monthly or as needed).

225 ose who received placebo, with an infrequent dosing regimen and an acceptable safety profile.

226 on to clinically acquired image data using a dosing regimen of 3.7 MBq/kg, images from simulated low-

227 ross diverse paradigms, varying the dose and dosing regimen, prion strain, treatment timepoint, and e

228 as well as simplification of the medication dosing regimen.

229 s are therefore needed to define the optimal dosing regimen.

230 , that opens new avenues for evaluating drug dosing regimens and understanding growing resistance of

231 ductions to the lowest recommended pediatric dosing regimens are possible when using PET/MRI.

232 mechanisms elicited by different irradiation dosing regimens could improve radiotherapy selection for

233 , in reducing risk of colectomy, (6) optimal dosing regimens for intravenous corticosteroids and infl

234 de the design of optimal drug candidates and dosing regimens for minimizing the emergence of resistan

235 ary embolism randomly assigned to 1 of 4 tPA dosing regimens for ultrasound-facilitated, catheter-dir

236 ated tPA (tissue-type plasminogen activator) dosing regimens for ultrasound-facilitated, catheter-dir

237 sought to evaluate the efficacy/safety of 4 dosing regimens of grass allergen peptides after a secon

238 is crucial to identify potentially effective dosing regimens of hydroxychloroquine.

239 d the activity and safety of three different dosing regimens of oral panobinostat in combination with

240 Three dosing regimens of RBX7455 were safe and effective at pr

241 proximately 40% of patients in both exercise dosing regimens were classified as VO(2)peak responders

242 going clinical trials with HCQ use different dosing regimens, resulting in various concentrations.

243 t-reducing strategies, including alternative dosing regimens.

244 the efficacy and effectiveness of different dosing regimens.

245 mall increments in occupancy attained by BID dosing relative to QD dosing compounded over time to aug

246 However, weight-based dosing remains the norm globally.

247 periments provided estimates on the rifampin dosing required to achieve cure in 4 months.

248 using pharmacokinetic/pharmacodynamic-guided dosing, requiring a median of 11 doses of eculizumab (in

249 e of 10 mg/kg (600 mg for flat-dosing), flat-dosing resulted in higher median AUC0-24h compared to th

250 e meter of body-surface area on a continuous dosing schedule (28-day cycles).

251 proliferation within the aorta after a short dosing schedule (7 days) and with a favorable toxicity p

252 e (months 0, 6, and 12) or on an accelerated dosing schedule (months 0, 2, and 6) and/or given before

253 ata by ranibizumab dose were pooled; data by dosing schedule (pro re nata [PRN] and monthly) were eva

254 ies who received RTX under an individualized dosing schedule adapted to the biological effect of RTX

255 accine (PCV13) in January 2015 using a 3 + 0 dosing schedule and no catch-up campaign.

256 We conclude that an accelerated dosing schedule of CYD-TDV results in essentially equiva

257 the mothers 1 month after completion of the dosing schedule, and the primary safety outcomes were fr

258 ort-term exercise training, independently of dosing schedule, is associated with modest improvements

259 RS, type of immune checkpoint blockade, and dosing schedule, was able to predict patients with and w

260 and the safety and toxicity profile of each dosing schedule.

261 safety and toxicity profile of intermittent dosing schedules of CH5126766, and the antitumour activi

262 d the immunogenicity and safety of different dosing schedules of inactivated influenza vaccine in pre

263 at discharge in subjects from all 3 arginine-dosing schemes; greatest increase occurred with a loadin

264 The findings suggest that vancomycin dosing should be guided by the AUC and day 2 AUCs should

265 Relative to the dosing solution, C6 and C7 perfluoroalkyl sulfonates (PF

266 Dosing standards remain undetermined, however, and wheth

267 kidney drug elimination, current kidney drug dosing strategies are on the basis of eGFR.

268 thematical model is used to rapidly evaluate dosing strategies for IL6 pathway modulation.

269 cluding autoinduction, and determine optimal dosing strategies for short-course rifapentine-based reg

270 centrations used to determine pharmaceutical dosing strategies.

271 Ideally such evaluations should address the dosing strategy in human applications and provide suffic

272 many cancers is chemotherapy, for which the dosing strategy is primarily limited by patient toxicity

273 We sought to evaluate a new dosing strategy of nemolizumab in patients with AD.

274 nical investigation of the co-administration dosing strategy to improve the tumor penetration of ADCs

275 low/late high or sustained high vasopressor dosing strategy was associated with higher mortality.

276 mpared to an early high/late low vasopressor dosing strategy, an early low/late high or sustained hig

277 currence of immediate-type reactions to food dosing subsequent to weaning of omalizumab was associate

278 When dosing such extracts into in vitro bioassays, co-dosed l

279 of these studies depends upon human-relevant dosing, surprisingly little is known about THC pharmacol

280 Dosing symptom frequency in participants who are BE-tole

281 tly lower among children receiving escalated dosing than among those receiving a fixed dose.

282 s compared to children receiving 2p+1b PCV13 dosing, those receiving 1p+1b and 2p+0b schedules experi

283 ct of vasopressor dosing intensity varies by dosing titration pattern.

284 ention Trials Network (HPTN) 067/Alternative Dosing to Augment PrEP Pill Taking (ADAPT) Study evaluat

285 g assays were conducted prior to artefenomel dosing to investigate parasite transmissibility.

286 ematologic toxicity resulted in more reduced dosing/treatment discontinuation in arm B vs arm C.

287 lso received two injections during the first dosing visit.

288 For all patients, ribavirin dosing was determined by baseline weight (up to 1,400 mg

289 Passive dosing was here designed to meet these challenges by max

290 h good overall drug-like properties for oral dosing, was well tolerated across preclinical species at

291 ening period documenting stable ESA and iron dosing, we randomized 61 patients with elevated IL-6 (>=

292 e groups between flat-dosing and weight-band dosing were considered low (< 20%) except for the lowest

293 OX as a faster acting antimalarial at higher dosing whose multiple mechanisms would be expected to li

294 The antiviral efficacy of weekly oral dosing with 3 mg/kg GS-9688 was confirmed in a second wo

295 Acute dosing with perampanel significantly rescued behavioral

296 d sorafenib concentrations after therapeutic dosing with response.

297 erebroventricular enzyme replacement therapy dosing with rhbeta-Gal is a tunable approach that can sa

298 n of intermittent enzyme replacement therapy dosing with rhbeta-Gal, followed by enzyme withdrawal, i

299 Continuous dosing yielded a statistically significant improvement i

300 Weight-band dosing yields a small and non-clinically relevant decrea