ライフサイエンスコーパス: double-positive

1 The first population was: 1) CD4(+)/CD8(+) double-positive; 2) specific for an HLA class I-restrict

2 5(-)CD44(-)) proliferation, and CD4(+)CD8(+) double-positive activation as well as developmental bloc

3 In this paper, we show human CD4/CD8 double-positive, acute graft-versus-host disease-protect

4 jor defects in the generation of CD4 and CD8 double-positive alphabeta T cells, whereas gammadelta T

5 ority of patients, but can be challenging in double positive and test negative patients.

6 CD4 is expressed in double-positive and CD4 cells but irreversibly silenced

7 n of CD4 single-positive thymocytes, whereas double-positive and CD8 single-positive thymocytes were

8 into monovalent activating modifications in double-positive and CD8 SP cells.

9 ermore, identification of IL-17A(+) Foxp3(+) double-positive and ex-IL-17-producing IL-17A(neg)Foxp3(

10 However, the numbers of double-positive and single-positive thymocytes after CD3

11 show that this role of Ikaros is specific to double-positive and single-positive thymocytes because d

12 4(-) thymocytes (that included CD4(+)/CD8(+) double-positive, and CD4(+) and CD8(+) single-positive c

13 at multiple stages; from DN3 through to DN4, double-positive, and single-positive CD4 and CD8.

14 for phenotypic markers further identified a double-positive aSma+ Mac3+ cell population, which is sp

15 ese included expansion of CD19(+) and CD5(+) double-positive B cells similar to the aggressive form o

16 Cross-arm avidity targeting of antigen double-positive cancer cells over single-positive normal

17 kewed in PGN+poly(I:C)-treated uterus toward double-positive CD11c(+) (M1) and CD206(+) (M2) cells, w

18 istant cells were enriched 5- to 22-fold for double-positive (CD133(+)/CD44(+)) cells.

19 Foxp3 Eomes double-positive CD4(+) T cells were capable of eliminati

20 ot caused by a block in differentiation from double-positive CD4(+)CD8(+) cells.

21 stricted deletion resulted in the absence of double-positive CD4(+)CD8(+) thymocytes, whereas bone-ma

22 recedes acute cell loss in the TN3, TN4, and double positive (CD4(+), CD8(+)) cell stages.

23 Double-negative (CD4(-)8(-)) and double-positive (CD4(+)8(+)) thymocytes were confined to

24 y of mainstream thymocyte development at the double-positive (CD4(+)CD8(+)) stage.

25 Immature double-positive (CD4(+)CD8(+)) thymocytes respond to neg

26 ere characterized as IL-17 (IL-17 and GM-CSF double-positive) CD4 cells.

27 ions exhibited an increased CD14(+)/CD206(+) double-positive cell population compared with normal tis

28 LZF-expressing cells were first found at the double-positive cell stage.

29 (-)CD8(-) (double negative) to CD4(+)CD8(+) (double positive) cell stages, whereas T cell activation

30 well as TrkA(+)/TrkB(+) and TrkA(+)/TrkC(+) double positive cells at early embryonic stages.

31 In comparison, the double positive cells remained at a basal level in mice

32 inefficient differentiation of CD4(+)CD8(+) double positive cells.

33 tivated cell sorting, only Prominin-1/Nestin double-positive cells fulfilled the defining stem cell c

34 ers of IFN-gamma-positive or IL-17/IFN-gamma-double-positive cells generated under Tc17 conditions al

35 Array analysis of TCR-stimulated double-positive cells identified SAP-1-dependent inducib

36 d in an induction of doublecortin- and Sox10 double-positive cells in the adult SVZ.

37 determine percentages of Kit and FcepsilonRI double-positive cells in the peritoneum of wild-type (WT

38 resulted in the early expression of FoxP3 on double-positive cells in the thymic cortex.

39 T and B cells in the spleen and CD4(+)CD8(+) double-positive cells in the thymus of OPN(+/+) mice.

40 triple-positive and INF-gamma and TNF-alpha double-positive cells increasing over time, while INF-ga

41 During this process, agonist-selected double-positive cells lose CD4/8 coreceptor expression a

42 ments demonstrate that these nestin and BLBP double-positive cells represent a population of glial pr

43 ature single-positive and CD3(+)CD4(+)CD8(+) double-positive cells showed severe restriction of reper

44 Additionally, the number of Flk-1/CD34 double-positive cells towards the ischemic penumbra was

45 e transition from CD4/CD8 double-negative to double-positive cells was blocked, and lck-cre(+) double

46 Most double-positive cells were also positive for costimulato

47 ection with NC/02 or MN/99 plus TX/96, H1/H3 double-positive cells were identified.

48 e-positive cells was blocked, and lck-cre(+) double-positive cells were more prone to apoptosis and s

49 a dramatic increase in alpha-SMA(+), EP4(+) double-positive cells were observed in EP4cKO(S100a4) su

50 Finally, IL-17 and interferon gamma double-positive cells were significantly increased in IL

51 TCR activation in double-positive cells with stabilized beta-catenin trigg

52 green-dominant cells converted to green/red double-positive cells within 6 h.

53 gative thymocytes, expressed in CD4(+)CD8(+) double-positive cells, and silenced in cells committing

54 g distinct subtypes of somatostatin+/Reelin+ double-positive cells, including Hpse+ layer IV cells ta

55 se receptor (CD206) and the CD14(+)/CD206(+) double-positive cells, suggesting a polarization of macr

56 imilarly enhanced Pou4f3/GFP and myosin VIIa double-positive cells, when compared to hATOH1 alone.

57 ansition stage between double-negative 4 and double-positive cells.

58 e DN3 cells and premitotic arrest of CD4/CD8 double-positive cells.

59 ridge cells into Pou4f3/GFP and myosin VIIa double-positive cells.

60 impaired accumulation of alphabeta T lineage double-positive cells.

61 w cytometry and distinguished from green/red double-positive cells.

62 ue and further differentiate into IL-6/IL-17 double-positive cells.

63 re than a 5-fold increase in active Casp1/PI double-positive cells.

64 and a decreased percentage of CD4(+)/CD8(+) (double-positive) cells; the DN1/DN2 population was incre

65 traversal of the DN (double negative) > DP (double positive) checkpoint are required for ThPOK-media

66 ercentage of CD29(hi)/CD24(neg), CK5(+), and double-positive CK14/CK18 cells.

67 ) Sca-1(+), CD24(hi) CD29(+), CK19, CK6, and double-positive CK14/CK18 progenitor cells.

68 APP/beta-amyloid and Atg8/LC3 double-positive compartments were almost exclusively obs

69 CS analysis of CRH receptor (CRHR) and c-kit double-positive disaggregated mouse skin mast cells.

70 in T-cell development at the double-negative/double-positive (DN/DP) stages cooperate with cytokine-m

71 BAT was double positive/double negative/single positive in 6/2/1

72 Adoptive transfer of WT CD11b(+) Gr1(+) double positive (DP) cells, but not T cells, was suffici

73 Loss at the double positive (DP) stage of thymocyte development caus

74 pre-TCR beta-selection of thymocytes to the double positive (DP) stage.

75 is essential for maturation to the CD4+CD8+ double positive (DP) stage.

76 lations and demonstrate that mitochondria in double positive (DP) thymocytes are more primed for deat

77 is constitutively ubiquitylated in immature double positive (DP) thymocytes, but not mature single p

78 CD8(-) double negative (DN) and CD4(+)CD8(+) double positive (DP) thymocytes, respectively.

79 ly regulated plexinD1 expression on CD4+CD8+ double positive (DP) thymocytes.

80 quent proliferation and differentiation into double positive (DP) thymocytes.

81 ore sensitive than more mature CD4(+)CD8(+) [double positive (DP)] thymocytes to a weak pMHC-I agonis

82 and CD8 cells, but expressed in CD4(+)CD8(+) double-positive (DP) and CD4 cells.

83 The number of double-positive (DP) and single-positive (SP) T cells ar

84 Peripheral blood and thymic double-positive (DP) CD4(+)CD8(+) T cells from neonates

85 The differentiation of double-positive (DP) CD4(+)CD8(+) thymocytes to single-p

86 s the degradation of the TCR in preselection double-positive (DP) CD4(+)CD8(+) thymocytes.

87 )CD8(-) double-negative (DN)-to-CD4(+)CD8(+) double-positive (DP) cell transition, and this may be pa

88 -) double-negative (DN) cell to CD4(+)CD8(+) double-positive (DP) cell.

89 Thymic CD4+CD8+ double-positive (DP) cells from these mice were striking

90 , we demonstrate that ADAP-deficient CD4/CD8 double-positive (DP) cells have a diminished ability to

91 ve thymocytes and their differentiation into double-positive (DP) cells, where Trbv recombination is

92 aling cascades that allow for DN to CD4+CD8+ double-positive (DP) differentiation, proliferation, and

93 lation of a monocyte-derived CD11c(+)CD64(+) double-positive (DP) macrophage eWAT population with a p

94 -lineage, thereby decreasing the size of the double-positive (DP) pool, which is efficiently positive

95 -) double-negative stage to the CD4(+)CD8(+) double-positive (DP) stage and from the DP stage to the

96 uble-negative (DN) 3 cells progressed to the double-positive (DP) stage and up-regulated TCRalphabeta

97 ent, but their roles beyond the CD4(+)CD8(+) double-positive (DP) stage are unknown.

98 ry for their progression to the CD4(+)CD8(+) double-positive (DP) stage of T cell development.

99 EB was uniquely required at the CD4(+)CD8(+) double-positive (DP) stage of T cell development.

100 a differentiation block at the CD4(+)CD8(+) double-positive (DP) stage.

101 ymocytes to the DN4, and subsequently to the double-positive (DP) stage.

102 inase (MMP)-1/2/9 genes compared with DN and double-positive (DP) subpopulations.

103 and DN2 T cell progenitors and CD4(+)CD8(+) double-positive (DP) T cell precursors, but increased fr

104 tion in RAG expression at the immature B and double-positive (DP) T cell stages is mediated through t

105 individuals possess circulating CD4(+)CD8(+) double-positive (DP) T cells specific for HIV Ags.

106 and to cause a partial block in CD4(+)CD8(+) double-positive (DP) thymocyte development in mice.

107 Death by neglect requires that CD4+8+ double-positive (DP) thymocytes avoid cytokine-mediated

108 In this study, HDAC3-deficient double-positive (DP) thymocytes exhibit a severe decreas

109 The mutant double-positive (DP) thymocytes exhibited spontaneous hy

110 Deficiency in the TF Bcl11b in double-positive (DP) thymocytes has been shown to cause

111 s that regulate the lifespan of CD4(+)CD8(+) double-positive (DP) thymocytes help shape the periphera

112 Moreover, the signals that retain CD4+CD8+ double-positive (DP) thymocytes in the cortex and preven

113 Survival of CD4(+)CD8(+) double-positive (DP) thymocytes plays a critical role in

114 ranscriptional control of gene expression in double-positive (DP) thymocytes remains poorly understoo

115 Double-positive (DP) thymocytes respond to intrathymic T

116 7) regulates CD8(+) T cell fate decisions in double-positive (DP) thymocytes through the sequential s

117 cell development from immature CD4(+)CD8(+) double-positive (DP) thymocytes to the mature CD4 or CD8

118 involves coculture of TCR(hi)CD5(int)CD69(-) double-positive (DP) thymocytes with peptide-pulsed OP9

119 The iNKT cells derive from CD4(+)CD8(+) double-positive (DP) thymocytes, and their generation re

120 tion of V(beta)-to-DJ(beta) recombination in double-positive (DP) thymocytes, which correlates with r

121 Their positive selection is mediated by double-positive (DP) thymocytes, which present glycolipi

122 r cells that differentiate into CD4(+)CD8(+) double-positive (DP) thymocytes, which then rearrange th

123 ntiation that is highly expressed in CD4/CD8 double-positive (DP) thymocytes.

124 es variegated Cd8 expression in CD4(+)CD8(+) double-positive (DP) thymocytes.

125 Cs) promotes apoptosis of the CD4(hi)CD8(hi) double-positive (DP) thymocytes.

126 The double-positive (DP) to single-positive (SP) transition

127 repertoire selection and the transition from double-positive (DP) to SP cell in a physiological situa

128 subsequent transition from the CD4(+)CD8(+) double-positive (DP) to the CD4(+) or CD8(+) single-posi

129 stalls the developmental transition from the double-positive (DP) to the single-positive (SP) thymocy

130 Immature CD4(+)CD8(+) (double-positive (DP)) thymocytes are signaled via T cell

131 ansiently expressed during the CD4(+)CD8(+) (double positive [DP]) stage of T cell development, in as

132 Conversely, CD163(+)CD206(+) (double-positive [DP]) alveolar macrophages are long-live

133 ecombine, and inaccessible in CD4(+)/CD8(+) (double-positive [DP]) thymocytes, when they do not rearr

134 CD4((+))CD8((+)) "double positive" (DP) thymocytes differentiate into dive

135 The CD4(+)CD8(+) (double positive, DP) stage of thymic development is thou

136 ce of maturational conversion of EEA1/NEEP21 double-positive endosomes.

137 Among the 112 serum samples, we found 22 double positive (EP-I and EP-II), 6 EP-II positive only,

138 was an approximate 20-fold increase in cells double positive for TSPO and HLA-DR in active lesions an

139 ed as being negative for lineage markers and double-positive for CD45/CD127.

140 erial endothelium, and identified many cells double-positive for HMGA1 and SM22alpha in occlusive and

141 nts; however, its effect on patients who are double-positive for wheals and angioedema has not been s

142 Recently, traces of double-positive FoxP3(+)RORgammat(+) T cells were identi

143 The double-positive fraction of gata2a:GFP and runx1:mCherry

144 (TNF-alpha) and gamma interferon (IFN-gamma) double-positive functional phenotype was associated with

145 The CD161high CCR6+ double-positive gammadelta T-cell population was further

146 nitors are derived from the tcf21 and nkx2.5 double-positive head mesoderm and require these two tran

147 d for selective targeting and eradication of double-positive human NCI-H358 non-small cell lung cance

148 whereas galectin-1 kills double-negative and double-positive human thymocytes with equal efficiency,

149 There were double-positive IL-17+IL-22+ cells [TH17(22)], and the I

150 at prevention of maturation of CD4(+)/CD8(+) double-positive immature T cells is important in ZNF198-

151 pha (TCRalpha) rearrangement in CD4(+)CD8(+) double-positive immature thymocytes is a prerequisite fo

152 ession in thymocytes blocks progression from double-positive immature thymocytes, resulting in comple

153 ll intestine contains CD4(+)CD8alphaalpha(+) double-positive intraepithelial lymphocytes (DP IELs), w

154 Quantification of double-positive LacZ(+) and CD31(+) endothelial cells or

155 to be involved in the positive selection of double-positive lymphocytes and appears to play a role i

156 (-)CD8(-) (double-negative) to CD4(+)CD8(+) (double-positive) maturation because of low TCR expressio

157 aled an enrichment in AhR/IL-6 and AhR/IL-17 double-positive MCs within bronchial lamina propria.

158 se, they form a distinct pool of KLRG1 CD127 double-positive memory T cells and rapidly produce both

159 h enzalutamide and/or abiraterone FASN/AR-V7 double-positive metastases were found in 77% of cases.

160 class II molecules and that more than 40% of double-positive muscle fibers had contact with CD4(+) an

161 appearance of VEGF receptor 1 (VEGFR1)/CD11b double-positive myeloid cells in peripheral blood.

162 tment increased the numbers of granulocytes, double-positive myeloid cells, and macrophages at sites

163 e numbers or proportions of CD4(+),CD8(+) or double-positive or double-negative thymocytes, except th

164 Double-positive (PD-1(+)CTLA-4(+)) CD8(+) TIL had charac

165 T cells that exhibited an SLAMF1(+)SLAMF6(+) double positive phenotype were largely contained within

166 D45 negative, EpCAM/pan-cytokeratin (pan-CK) double-positive population after excluding debris, doubl

167 The lymphoblasts were composed of a CD4/CD8 double-positive population that aberrantly expressed CD4

168 centage of apoptotic cells were found in the double-positive population, and down-regulation of thymo

169 ateral genetic ablation of the 175 Cdh9/Dbx1 double-positive preBotC neurons in adult mice left breat

170 tive' thymocytes from CD4(+)CD8alphabeta(+) 'double-positive' precursors.

171 The double-positive result indicated 46% and 39% point risk

172 ite expression of the DC marker CD11c, these double-positive rMPs displayed the features of Msmall ef

173 The Pearson correlation coefficient for double-positive samples was 0.57, indicative of a modera

174 Depleting EP-II antibodies from double-positive serum samples increased 50% inhibitory d

175 and Treg, as well as co-inhibitory molecules-double-positive, severely exhausted PD-1(+)CD8(+) T cell

176 on with the TCGA database indicated a higher double-positive signal in basal-like breast cancer than

177 negatively selected cells are deleted at the double positive stage in the thymic cortex, compared wit

178 ce of gammadelta potential through the early double positive stage of development.

179 tion at the CD24(+)CD73(-)SLAMF1(+)SLAMF6(+) double positive stage that was associated with a decreas

180 row progenitor cells fail to progress to the double positive stage when cultured on OP9 stromal cells

181 mainstream thymocyte differentiation at the double positive stage, and recent work has revealed how

182 s in a block in thymocyte development at the double positive stage.

183 gulation of CD34, and plateaued at the early double positive stage.

184 ) progenitors and stays high until the early double-positive stage (CD3(-)CD4(+)CD8alpha(+)beta(-)).

185 ng Valpha14 to Jalpha18 recombination at the double-positive stage and enhanced proliferation of iNKT

186 on from the beta-selection checkpoint to the double-positive stage in an osmostress-independent manne

187 lection and lineage fate at the CD4(+)CD8(+) double-positive stage of intrathymic T-cell development.

188 y demonstrates that removal of Bcl11b at the double-positive stage of T cell development or only in T

189 the TCR for selection from the CD4(+)CD8(+) double-positive stage to the CD4 or CD8 single-positive

190 thymocytes, development to the CD4(+)CD8(+) double-positive stage was impaired, due to increased apo

191 abeta T cell development at the CD4(+)CD8(+) double-positive stage, although other lymphoid lineages

192 of a rec-Valpha14-Jalpha18 transgene at the double-positive stage, thus defining a role for NKAP in

193 single-positive (ISP) stage and the CD4/CD8 double-positive stage, with few mature CD4(+) or CD8(+)

194 killer T cell development is blocked at the double-positive stage.

195 arrangement early in development, before the double-positive stage.

196 locked in the transition to the CD4(+)CD8(+) double-positive stage.

197 or PRLR all imparted some progression to the double-positive stage.

198 uring the DN4, immature single-positive, and double-positive stages of development before thymic sele

199 ed during transition from DN to CD4(+)CD8(+) double-positive stages, it is maintained through heritab

200 larity and blocks at the double-negative and double-positive stages.

201 e CD8 immature single-positive and CD4+ CD8+ double-positive stages.

202 population, specifically the CD24(+)CD15(+) double-positive subpopulation, was selectively decreased

203 activity is elevated in cell-sorted DN4 and double-positive subpopulations.

204 and the highly proliferative ELF5(+)/CDX2(+) double-positive subset of cytotrophoblast cells demarcat

205 n important role for RASA1 as a regulator of double-positive survival and positive selection in the t

206 for IL-17 production by Th17, generation of double positive T cells expressing IL-17 and IFN-gamma,

207 xpression for miR-323-3p in IL-22- and IL-17-double-positive T cells and its capacity to suppress mul

208 17 single-producing T cells, IL-17/IFN-gamma double-positive T cells are found in significantly eleva

209 nd CD3epsilon it was possible to isolate the double-positive T cells in spleen and head kidney.

210 nd from CD4-CD8- double-negative to CD4+CD8+ double-positive T cells in the thymus.

211 )CD11c(-) cells, which resemble CD4(+)CD8(+) double-positive T cells in the thymus; and (e) CD34(-)CD

212 w) immature single-positive CD8(+) cells and double-positive T cells.

213 ce of intra-graft memory TNF-alpha and IL-17 double-positive T helper type 17 (Th17) cells is a leadi

214 or LMO1 was found in primary human TAL1/LMO1 double-positive T-ALL samples previously described by Fe

215 bone marrow pro-B cells and in CD4(+)CD8(+) double positive thymic T cells.

216 gy in lymphoid tissues but preserved CD4/CD8 double-positive thymic T cell pools.

217 and that was critical for double-negative to double-positive thymocyte differentiation and survival i

218 n is markedly higher in the Glut1-expressing double-positive thymocyte population than in any of the

219 -1 functions together with Bcl-xL to promote double-positive thymocyte survival.

220 Complement binding decreased from the double-positive thymocyte to the single-positive stage,

221 s transit through the immature CD4(+)CD8(+) (double-positive) thymocyte stage.

222 nterleukin-22 (IL-22) in response to loss of double positive thymocytes and upregulation of IL-23 by

223 l stage-specific regulation, being active in double positive thymocytes but not in DN thymocytes as i

224 Finally, we evaluated CD4/CD8 double positive thymocytes expressing surface MR1.

225 Surprisingly, however, some early double positive thymocytes retained gammadelta potential

226 ious difference in the apoptosis of CD4+CD8+ double positive thymocytes was observed between CnAbeta-

227 Preincubation of double positive thymocytes with exogenous bacterial liga

228 quires MHC-related 1-expressing CD4(+)CD8(+) double positive thymocytes, whereas thymic B cells, macr

229 identified was negative selection of CD4/CD8 double positive thymocytes.

230 ation of high-affinity signaled CD4(+)CD8(+) double-positive thymocytes and CD8(+) and CD4(+) single-

231 CD44(hi)CD122(hi) cells were found among double-positive thymocytes and increased in frequency du

232 difying factor TRIM28 is highly expressed in double-positive thymocytes and persistently phosphorylat

233 positive selection of immature CD4(+)CD8(+) double-positive thymocytes and their commitment to the C

234 Shn2(-/-) double-positive thymocytes are more sensitive to TCR-ind

235 However, double-positive thymocytes are positively selected to su

236 s no role in Notch target gene repression in double-positive thymocytes but rather that it is Ikaros

237 d further V(beta)-DJ(beta) rearrangements in double-positive thymocytes by separating the V(beta) gen

238 l tuner of TCR signaling, mir-181a-1/b-1, in double-positive thymocytes dampened TCR and Erk signalin

239 ymocytes but is not affected in CD4(+)CD8(+) double-positive thymocytes despite high expression of Th

240 gen receptor (TCR) signaling in CD4(+)CD8(+) double-positive thymocytes determines cell survival and

241 4(+) and CD8(+) single-positive subsets, and double-positive thymocytes exhibited increased Ca(2+) mo

242 CD4/CD8 double-positive thymocytes express the transcriptional r

243 Because double-positive thymocytes expressing CD1d select natura

244 ells and substantially lower in T cells, and double-positive thymocytes had a notably higher response

245 rescue the transition of double-negative to double-positive thymocytes in RAG-null mice, but is unab

246 beta-catenin/Tcf signaling was activated in double-positive thymocytes in response to alphabetaTCR e

247 Our results indicate that Shn2(-/-) double-positive thymocytes inappropriately undergo negat

248 MHC class II-expressing double-positive thymocytes induce progression of CD4(+)

249 Differentiation of CD4+CD8+ double-positive thymocytes into CD8+ single-positive (SP

250 Rescue in SLP76(-/-)Cbl(-/-)Y3F double-positive thymocytes is associated with enhanced t

251 selection of MHC class I-restricted CD4+CD8+ double-positive thymocytes is markedly inhibited in mice

252 sustained entry of Ca(2+) into CD4(+)CD8(+) double-positive thymocytes is required for positive sele

253 s are able to detect early stage CD4(+)CD8(+)double-positive thymocytes on which T-cell receptors are

254 etion of Tet2 and Tet3 in mouse CD4(+)CD8(+) double-positive thymocytes resulted in dysregulated deve

255 Notably, Git2(-/-) double-positive thymocytes showed greater activation of

256 Conditional ablation of c-Myc in double-positive thymocytes specifically impacted iNKT bu

257 thymus of CD5DeltaCK2BD mice contained fewer double-positive thymocytes than did that of both CD5WT a

258 ransgene led to highest expression levels in double-positive thymocytes that are normally devoid of D

259 ent uniquely depends on interactions between double-positive thymocytes that provide key homotypic in

260 his study that costimulation of preselection double-positive thymocytes through the signaling lymphoc

261 s to assemble Tcrd genes and in CD4(+)CD8(+) double-positive thymocytes to assemble Tcra genes.

262 double-negative thymocytes and CD4(+)CD8(+) double-positive thymocytes to generate diverse TCRdelta

263 f miR-181a/b-1 reduced the responsiveness of double-positive thymocytes to TCR signals and virtually

264 at Themis protein expression is increased in double-positive thymocytes undergoing positive selection

265 Death of CD4(+)CD8(+) double-positive thymocytes was increased in RASA1-defici

266 r p300 or CBP led to a decrease in CD4+ CD8+ double-positive thymocytes, but an increase in the perce

267 ighly similar with respect to the numbers of double-positive thymocytes, CD4(+)CD8(-) T cells, regula

268 ively suppressed in late double-negative and double-positive thymocytes, coinciding with the peak in

269 In double-positive thymocytes, concomitant binding of Mi-2b

270 shows decreased cell number, reduced CD4CD8 double-positive thymocytes, diminished expression of TCR

271 Bcl11b locus results in failure to generate double-positive thymocytes, implicating a critical role

272 otch target genes is observed in Ikaros null double-positive thymocytes, in the absence of detectable

273 AC7), a class IIa HDAC expressed in CD4+CD8+ double-positive thymocytes, is regulated by its nucleocy

274 Furthermore, using this approach, double-positive thymocytes, macrophages, and dendritic c

275 I or II, and are selected by CD1-expressing double-positive thymocytes, rather than by the thymic st

276 teractions by looping in double-negative and double-positive thymocytes, respectively.

277 ow that TH-POK can also upregulate GATA-3 in double-positive thymocytes, suggesting the existence of

278 When YY1 was depleted in double-positive thymocytes, they underwent increased cel

279 e block in positive selection of CD4 and CD8 double-positive thymocytes, yet the role of the NFATc pr

280 tributed across this domain, specifically in double-positive thymocytes.

281 ocytes despite high expression of Themis1 in double-positive thymocytes.

282 cytes and Tcra gene segments in CD4(+)CD8(+) double-positive thymocytes.

283 d triggered by the depletion of CD4(+)CD8(+) double-positive thymocytes.

284 ) and J(alpha) segments for recombination in double-positive thymocytes.

285 gen receptor (TCR) signals by CD4(+ ) CD8(+) double-positive thymocytes.

286 egulating the chemokine-mediated motility of double-positive thymocytes.

287 ctivator RBP-Jkappa was abrogated in Ik(-/-) double-positive thymocytes.

288 st the DN3 to DN4 checkpoint and to generate double-positive thymocytes.

289 CD4 gene in CD4-positive hybridoma cells and double-positive thymocytes.

290 as well as differentiation into CD4(+)CD8(+) double-positive thymocytes.

291 increases and peaks on CD3(high)CD4(+)CD8(+) double-positive thymocytes.

292 a-chain genes are assembled in CD4(+)CD8(+) (double positive) thymocytes due, in part, to the develop

293 ng the attenuation of CD8 avidity during the double-positive to CD8 single-positive progression.

294 ocyte development during transition from the double-positive to single-positive stage.

295 lls displayed further block from CD4 and CD8 double-positive to single-positive transition compared w

296 yte development was partially blocked at the double-positive to single-positive transition.

297 T cell development at the double-negative 4:double-positive transition in the thymus, a loss of B ce

298 ors and thymocytes at the double-negative to double-positive transition.

299 velopmental arrest at the double-negative to double-positive transition.

300 assic signaling induced RORgammat(+)Foxp3(+) double-positive Tregs (biTregs), which carry the traffic