ライフサイエンスコーパス: double-strand break repair

1 essential for replication fork stability and double strand break repair.

2 s are now known to be required for efficient double strand break repair.

3 ular processes of homologous replication and double strand break repair.

4 d replication and with BLM/Sgs1 and MRN/X in double strand break repair.

5 X are accompanied by WIP1 suppression of DNA double strand break repair.

6 (NHEJ) is a critical error-prone pathway of double strand break repair.

7 ATM mutant cells exhibit impaired DNA double strand break repair.

8 NCJ in a homologous recombination pathway of double strand break repair.

9 randed DNA and performs the initial steps of double strand break repair.

10 homologous end-joining (NHEJ) pathway of DNA double strand break repair.

11 needed for homologous recombination and DNA double strand break repair.

12 vity to deoxycholate and was impaired in DNA double strand break repair.

13 M and KU70, which are both essential for DNA double-strand break repair.

14 tions of the Mre11/Rad50 (MR) complex in DNA double-strand break repair.

15 r after replication fork stalling and during double-strand break repair.

16 ks but does not influence the outcome of DNA double-strand break repair.

17 to inhibit DNA damage response signaling and double-strand break repair.

18 er chromatid interactions are sufficient for double-strand break repair.

19 pathway, which is the major pathway for DNA double-strand break repair.

20 tethering DNA ends, and thus participates in double-strand break repair.

21 an important enzyme in the initiation of DNA double-strand break repair.

22 3' non-homologous tail removal (3' NHTR) in double-strand break repair.

23 ith PARP1 activation, BRCA1 recruitment, and double-strand break repair.

24 re11-Rad50 complex, suggesting a link to DNA double-strand break repair.

25 In addition, mRtel1 is involved in DNA double-strand break repair.

26 Here we report that DEK is important for DNA double-strand break repair.

27 sary intermediate for recombination-mediated double-strand break repair.

28 d51 nucleofilaments that form during meiotic double-strand break repair.

29 bsequent to RNF8 accrual, and for proficient double-strand break repair.

30 the nonhomologous end-joining pathway of DNA double-strand break repair.

31 end capture step envisioned in models of DNA double-strand break repair.

32 om its Ctp1- and resection-dependent role in double-strand break repair.

33 evidence supporting a role in staggered DNA double-strand break repair.

34 ATM is a PI 3-kinase involved in DNA double-strand break repair.

35 the nonhomologous end-joining pathway of DNA double-strand break repair.

36 appears to be associated with defective DNA double-strand break repair.

37 orks and limits crossing over during mitotic double-strand break repair.

38 intaining low levels of SOS induction during double-strand break repair.

39 that methylates histone H3 and promotes DNA double-strand break repair.

40 loci suggest a role for this process in DNA double-strand break repair.

41 cription, replication, and more recently DNA double-strand break repair.

42 or the involvement of any HOX protein in DNA double-strand break repair.

43 evisiae, although it is not required for DNA double-strand break repair.

44 or DNA repair pathways, such as NER, BER and double-strand break repair.

45 se excision repair, mismatch repair, and DNA double-strand break repair.

46 n the HR pathway that mediates efficient DNA double-strand break repair.

47 -mediated strand exchange during error-prone double-strand break repair.

48 mic isoforms of WDR-23 differentially affect double-strand break repair.

49 53BP1 plays a central regulatory role in DNA double-strand break repair.

50 nce.DNA polymerase (pol) mu functions in DNA double-strand break repair.

51 in the non-homologous end-joining pathway of double-strand break repair.

52 ns or insertions-molecular signatures of DNA double-strand break repair.

53 re provides a flexible cradle to promote DNA double-strand-break repair.

54 homologous end-joining (NHEJ) pathway of DNA double-strand-break repair.

55 sion repair, nucleotide excision repair, and double-strand breaks repair.

56 tivity to the repair gene BRCA2, involved in double-stranded break repair.

57 AD51 focus formation, an essential marker of double-stranded break repair.

58 al roles in homologous recombination and DNA double-stranded break repair.

59 between parental chromosomes during meiosis double-stranded break repair.

60 overed that MTA1 is required for optimum DNA double-strand break repair after ionizing radiation.

61 T-cell lymphomas as a consequence of altered double strand break repair and increased survival of thy

62 end-joining pathway plays a critical role in double strand break repair and is uniquely responsible f

63 ination (HR) is important for error-free DNA double strand break repair and maintenance of genomic st

64 PTIP-dependent pathway is important for DNA double strand breaks repair and DNA damage-induced intra

65 ns, where there must be both a defect in DNA double-strand break repair and a subsequent failure of c

66 hanges have occurred in giraffe and okapi in double-strand break repair and centrosome functions.

67 he DNA damage response (DDR), governing both double-strand break repair and DDR signaling.

68 We subsequently examined mechanisms of double-strand break repair and found that loss of MSI1 r

69 sin is also required for postreplicative DNA double-strand break repair and gene expression.

70 The BRCA1-A and BRISC complexes serve in DNA double-strand break repair and immune signaling and cont

71 tral role in homologous recombination during double-strand break repair and in replication fork dynam

72 rgeted lysines on hMOF and TIP60 repress DNA double-strand break repair and inhibit the ability of hM

73 sex-specific age dependencies indicative of double-strand break repair and methylation-associated da

74 Double-strand break repair and mismatch repair subtypes

75 e11), along with ctp1Delta, are defective in double-strand break repair and most other functions of t

76 We suggest a role for this process in DNA double-strand break repair and present evidence to sugge

77 Our results reveal requirements for double-strand break repair and recombination during both

78 a highly processive DNA helicase involved in double-strand break repair and recombination that posses

79 The Mre11 complex promotes DNA double-strand break repair and regulates DNA damage sign

80 les in homologous recombination-mediated DNA double-strand break repair and replication fork processi

81 BRCA1 is best known for its functions in double-strand break repair and resolution of DNA replica

82 or RecO in two pathways of mycobacterial DNA double-strand break repair and suggest an in vivo functi

83 case with proposed roles in DNA replication, double-strand break repair and telomere maintenance.

84 vely, our results suggest a role for MSI1 in double-strand break repair and that its inhibition may e

85 ent protein kinase [DNA-PK]) crucial for DNA double-strand break repair and V(D)J recombination.

86 These patients exhibited a defect in DNA double-strand break repair and V(D)J recombination.

87 the nuclease activities in homology-directed double-strand-break repair and a contributing role in ac

88 e-stranded linear DNA and works with RecA in double-strand-break repair and SOS induction, and RuvABC

89 matid cohesion, it is also important for DNA double-strand-break repair and transcriptional control.

90 structure, thereby hiding telomere ends from double-stranded break repair and ATM signaling, whereas

91 RecA/Rad51 plays a key role in DNA double-stranded break repair and homologous recombinatio

92 creased induction of gamma H2AX foci and DNA double strand break repair, and decreased DNA damage sen

93 BRCA1 facilitates DNA double-strand break repair, and dysfunction of BRCA1 lea

94 functions in interstrand cross-link repair, double-strand break repair, and homologous recombination

95 ment known as V(D)J recombination, defective double-strand break repair, and increased chromosomal in

96 in completing replication is independent of double-strand break repair, and likely promotes joining

97 in X-chromosome inactivation, imprinting and double-strand break repair, and mutations in SMCHD1 cont

98 elated to mismatch repair in eukaryotes, DNA double-strand break repair, and nucleotide excision repa

99 (DNA-PKcs) has well-established roles in DNA double-strand break repair, and recently, nonrepair func

100 orks, increased crossover frequencies during double-strand break repair, and severe impairment in DNA

101 s diverse roles in DNA damage responses, DNA double-strand break repair, and transcriptional regulati

102 Pol IV-dependent mutagenesis associated with double-strand-break repair, and impaired maintenance of

103 ethylation at meiotic hotspots, impaired DNA double-strand-break repair, and reduced crossover number

104 end joining and/or replication-dependent DNA double-strand break repair are the dominant mechanisms i

105 n foreskin fibroblasts, a fluorescence-based double-stranded break repair assay was used to determine

106 cient cells displayed a significant delay in double-strand break repair associated with a profound an

107 ay in processing DNA ends, thereby diverting double-strand break repair away from abortive NHEJ and t

108 induced apoptosis suppressor (DDIAS) gene in double-strand break repair based on its coevolution with

109 framework, and a molecular model for meiotic double-strand break repair based on the concept of slidi

110 indicate that lamin A/C plays a role in DNA double strand break repair, but a role in DNA base excis

111 MRT-1 is dispensable for DNA double-strand break repair, but functions with the 9-1-1

112 H2AX participates in DNA double-strand break repair, but its role in other DNA re

113 and ATR] has well characterized roles in DNA double-strand break repair, but poorly understood roles

114 demonstrate that USP20 depletion impairs DNA double strand break repair by homologous recombination.

115 cilitates histone H2A ubiquitination and DNA double strand break repair by homologous recombination.

116 n for repressing transcription and promoting double strand break repair by homologous recombination.

117 ntageous in gap-filling synthesis during DNA double strand break repair by nonhomologous end joining,

118 y restore HR, whereas KAT5 depletion rewires double strand break repair by promoting 53BP1 binding to

119 ate that MOF depletion greatly decreased DNA double-strand break repair by both NHEJ and homologous r

120 deal therapeutic target, as it regulates DNA double-strand break repair by homologous recombination (

121 The Mre11/Rad50/Nbs1 complex initiates double-strand break repair by homologous recombination (

122 DNA double-strand break repair by homologous recombination b

123 DNA double-strand break repair by homologous recombination e

124 DNA double-strand break repair by homologous recombination i

125 t recurrent indels are enriched for the 'DNA double-strand break repair by homologous recombination'

126 ted plasmids showed that G5 was required for double-strand break repair by homologous recombination,

127 erevisiae, regulates early and late steps of double-strand break repair by homologous recombination.

128 in the paralog USP11, a key regulator of DNA double-strand break repair by homologous recombination.

129 the function of 53BP1, a key factor for DNA double-strand break repair by non-homologous end joining

130 (Ku70, Ku80, DNA-PK(cs)) responsible for DNA double-strand break repair by nonhomologous end joining

131 RPA directly participates in DNA double-strand break repair by stimulating 5'-3' end rese

132 Double-strand breaks repaired by homologous recombinatio

133 We establish that UVRAG promotes DNA double-strand-break repair by directly binding and activ

134 Twelve of 27 (45%) double-strand break repair cases lacked germline or soma

135 assay chromatin reassembly accompanying DNA double strand break repair, ChIP analysis can be used to

136 cting oxidative stress and affecting meiotic double-strand break repair, chromosome synapsis and cros

137 enomic patterns reflective of defects in DNA double-strand break repair, comparing HPV-associated and

138 However, unlike double-strand break repair, completion occurs independen

139 h Nbs1, a member of the Mre11/Rad50/Nbs1 DNA double-strand break repair complex.

140 iction to male germ cells elicits autonomous double-strand-break repair, consequently creating offspr

141 repair genes to irradiation and inefficient double-strand break repair correlated with severe late r

142 A DNA double-strand break repair-defective DNA-PKcs(-/-) tumor

143 te but not complete RAD51- and DMC1-mediated double-strand break repair, demonstrating that STAG3 is

144 nd that the contribution of SOS induction to double-strand break repair differs substantially between

145 l assembly of synaptonemal complexes and DNA double strand break repair, dissociation of MLH1, a comp

146 t RecD is one of three enzymes in the RecBCD double-stranded break repair DNA recombination complex.

147 ER), interstrand cross-links repair (ICL/R), double-strand breaks repair (DSB/R), and chromatin struc

148 hromosome synapsis and disruption of meiotic double-strand break repair (DSBR) progression.

149 DNA double-strand break repair (DSBR) proteins and the SOS a

150 Here, we inactivated DNA double-strand break repair (DSBR) proteins, DNA Ligase I

151 Understanding the mechanisms of chromosomal double-strand break repair (DSBR) provides insight into

152 defects in DNA damage response including DNA double-strand break repair (DSBR) through DNA end resect

153 e MRE11-RAD50-NBS1 (MRN) complex acts in DNA double-strand break repair (DSBR), detection, and signal

154 ssortment of genetic information and for DNA double-strand break repair (DSBR).

155 nizing radiation, indicating a defect in DNA double-strand break repair (DSBR).

156 ans histone demethylase SPR-5 in meiotic DNA double-strand break repair (DSBR).

157 thesis-dependent strand annealing (SDSA) and double-strand break repair (DSBR).

158 pieces of DNA together and is important for double-strand break repair (DSBR).

159 ngi and mammals is generated through mitotic double-strand break-repair (DSBR), typically involving h

160 Using small palindromes to monitor meiotic double-strand-break-repair (DSBr) events, we demonstrate

161 DDR proteins are also implicated in double strand break repair during meiotic recombination.

162 e class and an interference class of meiotic double-strand-break-repair events, each with its own rul

163 ts of cytokines on the activation of the DNA double strand break repair factors histone H2AX (H2AX) a

164 r Rad51-catalyzed DNA strand invasion during double-strand break repair features a 3' single-stranded

165 p processing for DinG and YoaA and a role in double-strand break repair for YejH.

166 ms26 target site consistent with products of double-strand break repair generated by non-homologous e

167 utation confers synthetic lethality with DNA double-strand break repair genes and increased sensitivi

168 , we performed mutational analysis of 32 DNA double-strand break repair genes in genomic DNA from 38

169 levels and temporal expression patterns for double-strand break repair genes were also distinct for

170 gamma-H2AX foci and reduced induction of DNA double-strand break repair genes.

171 We show that female mice with defective DNA double-strand break repair had significantly increased f

172 For double-strand break repair, HOXC10 recruits HR proteins

173 by supporting homologous recombination-type double strand break repair (HR-DSBR) through physical in

174 he support of homologous recombination- type double-strand break repair (HR-DSBR), checkpoint functio

175 specialized polymerase machinery involved in double-strand break repair, illuminate a powerful approa

176 ubstantiation of a direct role for pol IV in double strand break repair in cells treated with double

177 cN is a cohesin-like protein involved in DNA double-strand break repair in bacteria.

178 stress-induced mutations associated with DNA double-strand break repair in carbon-starved Escherichia

179 chromosome/chromatid breaks and delayed DNA double-strand break repair in cells lacking p53 but not

180 s recombination repair factors, impaired DNA double-strand break repair in chromosomal (but not in ep

181 ecBCD helicase-nuclease enzyme important for double-strand break repair in Escherichia coli.

182 Efficient double-strand break repair in eukaryotes requires manipu

183 tion in vitro has revealed similarities with double-strand break repair in eukaryotes.

184 -homologous end-joining (NHEJ), a pathway of double-strand break repair in influencing both the kinet

185 combination are two distinct pathways of DNA double-strand break repair in mammalian cells.

186 infer molecular intermediates formed during double-strand break repair in Saccharomyces cerevisiae.

187 ugh accumulating evidence has implicated DNA double-strand break repair in suppression of oncogenic g

188 lly induced by a higher level of error-prone double-strand break repair in these regions, which gener

189 in subunits SMC1 and Rad21 contribute to DNA double-strand break repair in X-irradiated human cells i

190 RNA can serve as a template for DNA double-strand break repair in yeast cells, and Rad52, a

191 enomic DNA to investigate the quality of the double-strand break repairs in the class-switch recombin

192 actors that control DNA end resection during double-strand break repair, including the Bloom syndrome

193 ctional interplay between hMSH5 and FANCJ in double-strand break repair induced by replication stress

194 own to promote chromatin reassembly when DNA double strand break repair is complete.

195 DNA double-strand break repair is critical for cell viabilit

196 DNA double-strand break repair is essential for maintenance

197 Homologous recombination (HR)-mediated DNA double-strand break repair is important for tumor suppre

198 Double-strand break repair is required for neural develo

199 An early step in double-strand break repair is the recruitment of ataxia-

200 hat functional defect of TERA/VCP/p97 in DNA double-stranded break repair is critical for the patholo

201 We find that LIG4, a DNA ligase in DNA double-strand break repair, is a direct target of beta-c

202 nd is required for timely pairing and proper double-strand break repair kinetics.

203 the extent to which available mechanisms of double-strand break repair limit the scope and utility o

204 tential functions: as a component of the DNA double-strand break repair machinery and as a ribonuclea

205 insic endonuclease activity and the cellular double-strand break repair machinery.

206 e recognized and repaired by the plant's DNA double-strand break-repair machinery.

207 Among double-strand break repair mechanisms induced by oncogen

208 representation of mutations caused by faulty double-strand break repair might explain the high struct

209 red PDAC into 4 major subtypes: age related, double-strand break repair, mismatch repair, and 1 with

210 his analysis also provides evidence that the double-strand break repair model applies to meiotic reco

211 e not explicable by the simplest form of the double-strand break repair model of recombination.

212 , these simple modifications of the original double-strand break repair model-asymmetry in recombinat

213 damage response mediators (RAD17 and RAD50), double-stranded break repair molecule 53BP1, G2 checkpoi

214 imary cause of genomic instabilities in many double-strand-break-repair mutants arises from an impair

215 and required the exonuclease activity of the double strand break repair nuclease (Mre11).

216 rotected forks are degraded by MRE11 homolog double-strand break repair nuclease (MRE11).

217 homologous recombination, and activation of double-strand break repair nuclease (MRE11).

218 RA T cells had low expression of the double-strand-break repair nuclease MRE11A, leading to t

219 w mutations appear to be caused by imprecise double-strand break repair, nucleotide misincorporation

220 tin remodeling and compaction as well as DNA double stranded break repair of sister chromatids.

221 repair of transcribed genes, and error-free double-strand break repair of a 3'-phosphate-containing

222 ce of unsynapsed sex chromosomes, incomplete double-strand break repair on synapsed pachytene chromos

223 ppear on chromosomes during telomere damage, double strand break repair or after the UV damage of sta

224 s broken chromosomes or assist in either DNA double-strand break repair or repair of single double-st

225 Pch2 has also been shown to modulate meiotic double-strand break repair outcomes to favor recombinati

226 Break induced replication (BIR) is a double strand break repair pathway that can promote gene

227 strand annealing rather than by a canonical double-strand break repair pathway and that resolution o

228 al. in this issue, provide insights into DNA double-strand break repair pathway choice in mammalian c

229 rhang structure is a critical determinant of double-strand break repair pathway choice.

230 and separable from 53BP1's regulation of DNA double-strand break repair pathway choice.

231 -homologous end joining (the predominant DNA double-strand break repair pathway in higher eukaryotes)

232 end joining (C-NHEJ) is the predominant DNA double-strand break repair pathway in humans.

233 s end-joining (cNHEJ) pathway is a major DNA double-strand break repair pathway in mammalian cells an

234 g is the primary deoxyribonucleic acid (DNA) double-strand break repair pathway in multicellular euka

235 nature associated with a backup, error-prone double-strand break repair pathway known as microhomolog

236 promote spontaneous SCE by influencing which double-strand break repair pathway predominates during n

237 translocations were likely mediated by a DNA double-strand break repair pathway termed nonhomologous

238 homologous end-joining (NHEJ) is a major DNA double-strand break repair pathway that is conserved in

239 Break-induced replication (BIR) is a DNA double-strand break repair pathway that leads to genomic

240 , and RTEL1 genes, which are involved in the double-strand break repair pathway, are associated with

241 referential use of the potentially mutagenic double-strand break repair pathway.

242 ch identified USP11 as a component of the HR double-strand break repair pathway.

243 mponent of the nonhomologous end-joining DNA double-strand break repair pathway.

244 ns via the non-homologous end joining (NHEJ) double-strand break repair pathway.

245 DNA methylation that utilizes endogenous DNA double strand break repair pathways.

246 ent methodologies to comprehensively profile double-strand break repair pathways in isogenic paired c

247 Cellular DNA double-strand break-repair pathways have evolved to prot

248 ht on structural attributes of this X-family double-strand break repair polymerase that impact its bi

249 s, such as ionizing radiation (IR), produces double-strand breaks, repaired predominantly in mammalia

250 ) is a non-homologous end joining (NHEJ) DNA double strand break repair protein.

251 ding protein 1 (53BP1) is a multi-functional double-strand break repair protein that is essential for

252 c gene, which encodes a critical nuclear DNA double-stranded break repair protein.

253 Finally, the recruitment of a subset of double-strand break repair proteins including RAD51 and

254 tagenic DNA repair pathway that included DNA double-strand break repair proteins RexAB, recombinase A

255 In this study, we examined the role of double-strand-break repair proteins in gene silencing an

256 n of TERA/VCP/p97 and interaction of related double-stranded break repair proteins, finally causing t

257 roles for PARP-3 and APLF in chromosomal DNA double-strand break repair reactions.

258 ors of DNA fidelity through diverse roles in double-strand break repair, replication stress, and meio

259 he nonhomologous end joining pathway for DNA double strand break repair requires Ku to bind DNA ends

260 Homologous recombination plays key roles in double-strand break repair, rescue, and repair of stalle

261 If unabated, MRN elicits a double-strand break repair response that blocks viral DN

262 t role for Mdm2 in the regulation of the DNA double-strand break repair response, genomic stability,

263 nd a gain of checkpoint signaling due to the double-strand break repair response.

264 By initiating or participating in double-strand break repair, SbcCD may provide DNA substr

265 ibition that imposes the requirement for DNA double strand break repair should selectively sensitize

266 dent manner, activate the ATR/ATRIP-CHK1 and double-strand break repair signaling pathways, and are d

267 the very small deletions often found at DNA double-strand break repair sites.

268 e11/Nibrin protein complex has a role in DNA double-strand break-repair, suggesting that these protei

269 In G2 phase cells, DNA double-strand break repair switches from DNA non-homolog

270 deoxycholate, as well as function of the DNA double strand break repair system.

271 Efficient and accurate DNA double-strand break repair systems have been demonstrate

272 icase (WRN) participates in DNA replication, double strand break repair, telomere maintenance, and p5

273 ence divergence on the efficiency of mitotic double-strand break repair templated by chromosomal sequ

274 LigIII acts in an alternative pathway of DNA double strand break repair that buttresses canonical non

275 involved in nonhomologous end joining of DNA double-strand break repair, the largest subgroup consist

276 SIRT6 stabilizes the genome by promoting DNA double strand break repair, thereby acting as a tumor su

277 tivator of ATM signaling, which promotes DNA double-strand break repair through homologous recombinat

278 lates the DNA damage response as well as DNA double-strand break repair through homologous recombinat

279 HMCES specifically enables DNA double-strand break repair through the microhomology-med

280 BRCA-deficient human cells and promotes DNA double-strand break repair through two pathways: homolog

281 duced signaling required for chromosomal DNA double-strand break repair, thus resulting in increased

282 To examine the contribution of double-strand break repair to CAG x CTG repeat instabili

283 error-prone nature of genome editing-induced double-strand break repair to map functional elements wi

284 ytotoxicity using BRCA1 mutants deficient in double-strand break repair unexpectedly revealed a disso

285 dentify TIRR as a new factor that influences double-strand break repair using a unique mechanism of m

286 xonuclease 5 (EXO5) gene in androgen-induced double strand breaks repair via homology-directed repair

287 the Rad52 protein mediates RNA-dependent DNA double-strand break repair via inverse strand exchange.

288 We found that double-strand break repair via RecA, RecBCD, RuvABC and

289 malian proteins, SFPQ and NONO, promotes DNA double-strand break repair via the canonical nonhomologo

290 orks have identified the role of PTEN in DNA double-strand break repair, vulnerabilities of PTEN-defi

291 DNA double-strand break repair was delayed or failed in unsy

292 ding of the mechanisms and regulation of DNA double strand break repair, we attempted to confirm that

293 Using Gal-HO-mediated double strand break repair, we have tested each of the c

294 Several genes involved in double-strand break repair were found to be significantl

295 ble to initiate RAD51- but not DMC1-mediated double-strand break repair, were not able to assemble th

296 The HOP2 protein is required for efficient double-strand break repair which ensures the proper syna

297 ed Top3 does not affect crossing over during double strand break repair, which is known to involve do

298 I3K pathway activation and also hindered DNA double-strand break repair, which both led to improved r

299 tudies indicating the role of R-loops in DNA double-strand break repair with an updated view of much-

300 The contribution of remodelling factors to double-strand break repair within heterochromatin during