ライフサイエンスコーパス: double-stranded

1 o the 3' ends of single-stranded and (fully) double-stranded acceptor RNAs.

2 We have designed a double-stranded adeno-associated virus containing a rat

3 Mechanisms underlying increases in double-stranded Alu RNAs in MS are obscure.

4 retrotransposition assay that identified the double-stranded break (DSB) repair and Fanconi anemia (F

5 Best studied in the context of DNA double-stranded break (DSB) repair, recombination enzyme

6 wn as CtIP), which regulates a DDR choice in double-stranded break (DSB) repair.

7 The distance between the Cas9-mediated double-stranded break (DSB) to the mutation site, rather

8 isomerases regulate DNA topology by making a double-stranded break in one DNA duplex, transporting an

9 Spontaneous double stranded breaks (DSBs) are the best predictor of

10 DNA double-stranded breaks (DSBs) are dangerous lesions thre

11 DNA double-stranded breaks (DSBs) are strongly associated wi

12 e achieved upon repair of CRISPR-induced DNA double-stranded breaks (DSBs) by homology-directed repai

13 tenance of telomeres and rDNA, and repair of double-stranded breaks (DSBs) induced by genotoxins with

14 DNA double-stranded breaks (DSBs) trigger human genome insta

15 plex) are similarly deficient in joining DNA double-stranded breaks (DSBs) with hairpinned termini.

16 DR) encompasses the cellular response to DNA double-stranded breaks (DSBs), and includes recognition

17 s recombination-mediated repair (HRR) of DNA double-stranded breaks (DSBs).

18 when in excess can increase the frequency of double-stranded breaks (DSBs).

19 a DNA helicase protecting against G4 induced double-stranded breaks and concomitant loss of cohesion,

20 feres with replication forks, leading to DNA double-stranded breaks and genomic instability.

21 ed meiotic gene transcription, impairment of double-stranded breaks and pairing between homologous ch

22 hromosomes of these bacteria was achieved by double-stranded breaks made by heterologous I-CeuI endon

23 f microbial DNA with CRISPR-Cas9 to generate double-stranded breaks near the targeted sequences great

24 ysis of germline transcripts, examination of double-stranded breaks using biotin-labeling DNA break a

25 HR-dependent repair of directly induced DNA double-stranded breaks.

26 nt depressants capable of rapidly denaturing double stranded DNA (dsDNA) linkers, and 8 compounds are

27 cal sensor for detection of acrylamide using double stranded DNA (dsDNA)/Hemoglobin (Hb)-modified scr

28 ubiquitin ligase is activated in response to double stranded DNA breaks (DSBs) where it mono-ubiquiti

29 distal' face, three statistically disordered double stranded DNA molecules bind across the proximal f

30 Compared to double stranded DNA, PX DNA has dramatically enhanced (s

31 Class-switched antibodies to double-stranded DNA (dsDNA) are prevalent and pathogenic

32 uence homology, the major capsid proteins of double-stranded DNA (dsDNA) bacteriophages, some archaea

33 e-induced DNA adducts, can be converted to a double-stranded DNA (dsDNA) form by using appropriate tr

34 interferons (IFNs) and nucleosome-associated double-stranded DNA (dsDNA) fragments (nsDNA) are the ha

35 The simple 5.2-kbp double-stranded DNA (dsDNA) genome expresses just seven

36 TSPV1 packages an 18.65-kb linear double-stranded DNA (dsDNA) genome with 31 open reading

37 ) equal to 16-encapsidating a tightly packed double-stranded DNA (dsDNA) genome(1-3).

38 (ssDNA), in-solution- and on-chip-hybridized double-stranded DNA (dsDNA) has been studied.

39 ies of small single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) have been measured by capill

40 sport measurements through single 30-nm-long double-stranded DNA (dsDNA) molecules with an experiment

41 system to answer fundamental questions about double-stranded DNA (dsDNA) packaging by viruses that ha

42 ormation of infectious virions in the tailed double-stranded DNA (dsDNA) phages, herpesviruses, and a

43 tivities on an extensive class of mismatched double-stranded DNA (dsDNA) targets.

44 zole cyanine dye K21 forms dye aggregates on double-stranded DNA (dsDNA) templates.

45 This filament binds to a donor double-stranded DNA (dsDNA) to form synaptic filaments,

46 ssDNA-RecA filament searches for homologous double-stranded DNA (dsDNA) to use as a template for the

47 rsaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unice

48 In contrast to tailed icosahedral double-stranded DNA (dsDNA) viruses infecting bacteria a

49 ntermediates and it is unclear whether large double-stranded DNA (dsDNA) viruses may be similarly sus

50 d that SN1-type agents preferably mutagenize double-stranded DNA (dsDNA), and the mutation signature

51 Four duplexes: double-stranded DNA (dsDNA), PNA/DNA, dsRNA (modified RN

52 r on single-stranded DNA (ssDNA) compared to double-stranded DNA (dsDNA), raising a key conceptual qu

53 nsible for the sensing of aberrant cytosolic double-stranded DNA (dsDNA), which is a hallmark of canc

54 AcrVA4 and AcrVA5 inhibit recognition of double-stranded DNA (dsDNA), with AcrVA4 driving dimeriz

55 ng interface exclusively occupies the strong double-stranded DNA (dsDNA)-binding surface on cGAS and

56 se in base editing requires the unwinding of double-stranded DNA (dsDNA)-for example by a CRISPR-Cas9

57 e converging fork and then translocate along double-stranded DNA (dsDNA).

58 a complementary DNA strand (cDNA) to form a double-stranded DNA (dsDNA).

59 ar-infrared) regimes could have an effect on double-stranded DNA (dsDNA).

60 inding extensive tracts (~8-10 kilobases) of double-stranded DNA (dsDNA).

61 quitinated, creating a channel that encloses double-stranded DNA (dsDNA).

62 iotic recombination intermediates by nicking double-stranded DNA adjacent to the junction points(9).

63 oacervate droplets prepared from mixtures of double-stranded DNA and an azobenzene cation.

64 Alpha-synuclein binds double-stranded DNA and helps to facilitate the non-homo

65 terminal domain displays strong affinity for double-stranded DNA and is sufficient for the accumulati

66 king and unstacking reactions in single- and double-stranded DNA and thus may help to define the mole

67 Formation of TLS was found in anti-double-stranded DNA antibody-positive mice, and the stru

68 fluorescence which was slightly enhanced in double-stranded DNA as compared to single-stranded oligo

69 During morphogenesis of double-stranded DNA bacteriophages, a molecular motor dr

70 for the capsid shell assembly of many tailed double-stranded DNA bacteriophages, some archaeal viruse

71 hich uses unique structures for programmable double-stranded DNA binding and cleavage.

72 High-affinity nucleosome binding blocks double-stranded DNA binding and maintains cGAS in an ina

73 ed that both affect the dynamic features and double-stranded DNA binding properties of Mre11, but in

74 with RNA (coacervates) to avid and specific double-stranded DNA binding.

75 t, independently of its nucleotide sequence, double-stranded DNA binds to a specific helix of the vWF

76 method, which predicts the extent to which a double-stranded DNA break site will utilize the microhom

77 are particularly susceptible to formation of double-stranded DNA breaks (DSBs) arising from physiolog

78 and acceptor genomic sequences subjected to double-stranded DNA breaks (DSBs) made by programmable n

79 predictably and independent of Cas9-induced double-stranded DNA breaks (which causes substantial ind

80 esulted from nuclear entry by Dox, promoting double-stranded DNA breaks and apoptosis.

81 Depletion of WRN induced double-stranded DNA breaks and promoted apoptosis and ce

82 tumours are often deficient in the repair of double-stranded DNA breaks by homologous recombination(8

83 of linked loci is limited as multiple nearby double-stranded DNA breaks created by Cas9 routinely res

84 Although Cas9 efficiently induces double-stranded DNA breaks in the early embryo and male

85 CRISPR/Cas9 causes double-stranded DNA breaks that can undergo DNA repair e

86 gly, CSR induced by staggered but not blunt, double-stranded DNA breaks was impaired by SAMHD1 deplet

87 parallel with CRISPRi/a, which do not induce double-stranded DNA breaks, revealed that a distinct set

88 us for homology-directed DNA repair (HDR) of double-stranded DNA breaks.

89 se activity against both single-stranded and double-stranded DNA but not RNA under the conditions tes

90 studies that reveal binding and scission of double-stranded DNA by shishijimicin A.

91 how that its packaging series initiates with double-stranded DNA cleavages that are scattered across

92 -stranded DNA of various lengths and through double-stranded DNA containing oxidative damage.

93 resent the structure of CcrM in complex with double-stranded DNA containing the recognition sequence.

94 ranscribes its RNA genome and integrates the double-stranded DNA copy into a host cell chromosome.

95 tion of the AIM2 inflammasome in response to double-stranded DNA damage triggers the production of cy

96 To initiate replication on a double-stranded DNA de novo, all organisms require prima

97 Following the detection of cytosolic double-stranded DNA from viral or bacterial infection in

98 or dissociation and release of SP during the double-stranded DNA genome packaging step accompanying p

99 ASFV has a large, double-stranded DNA genome that encodes over 150 protein

100 BKPyV has a circular, double-stranded DNA genome that is divided genetically i

101 edrovirus is an insect virus with a circular double-stranded DNA genome, which, among other multiple

102 endogenous reverse transcription to produce double-stranded DNA genomes, which sometimes looped out

103 served mechanism of APOBEC3 evasion by large double-stranded DNA herpesviruses.

104 modified mC residues in single-stranded and double-stranded DNA in vitro, while the extent of the re

105 lization microscopy (BALM) using fluorescent double-stranded DNA intercalators and optical astigmatis

106 ds, the resulting brightness of 2CNqA inside double-stranded DNA is the highest reported for a fluore

107 pair, is able to use NAD+ as a substrate for double-stranded DNA ligation.

108 In comparison to spCas9, miCas9 enhances double-stranded DNA mediated large size gene knock-in ra

109 's input strands and the restriction-induced double-stranded DNA melting resets the systems.

110 sitive charges on the inner rim of helicoid, double-stranded DNA molecules (dsDNA) could interact wit

111 he capture rate and translocation of 1-5 kbp double-stranded DNA molecules through solid-state nanopo

112 ge polarization and charge transport through double-stranded DNA of various lengths and through doubl

113 ns-RNA cleavage activities to defend against double-stranded DNA phages is not understood.

114 in resistance to 14 phylogenetically diverse double-stranded DNA phages using two model Escherichia c

115 Cyclic GMP-AMP synthase (cGAS) is a double-stranded DNA sensor that catalyses the synthesis

116 ands of individual data points per minute on double-stranded DNA standard (dsDNA) samples containing

117 ominantly cleaves the non-target strand of a double-stranded DNA substrate.

118 uvC active site to make RNA-guided breaks in double-stranded DNA substrates, an activity essential fo

119 orm programmable endonucleolytic cleavage of double-stranded DNA substrates, showing enhanced activit

120 transient DNA melting that may occur during double-stranded DNA surveillance by CRISPR-Cas9.

121 Double-stranded DNA tailed bacteriophages typically code

122 through single-stranded loops embedded in a double-stranded DNA template and is programmed by a set

123 E2 Y138.IMPORTANCE Papillomavirus (PV) is a double-stranded DNA tumor virus infecting the cutaneous

124 Merkel cell polyomavirus (MCPyV) is a human double-stranded DNA tumor virus.

125 During cell division, FtsK translocates double-stranded DNA until both dif recombination sites a

126 ties yielded seven complete or near-complete double-stranded DNA virus genomes.

127 of the most frequently identified drivers of double-stranded DNA viruses evolution.

128 Giant and large eukaryotic double-stranded DNA viruses from the Nucleo-Cytoplasmic

129 More recently, several oncogenic double-stranded DNA viruses have been found to encode ci

130 but recent evidence suggests that some large double-stranded DNA viruses may also endogenize into the

131 CrAss-like phages are double-stranded DNA viruses that are prevalent in human

132 lve the atomic structures of two filamentous double-stranded DNA viruses that infect archaeal hosts l

133 The Nudiviridae are a family of large double-stranded DNA viruses that infects the cells of th

134 us expression of a cloned A* gene.IMPORTANCE Double-stranded DNA viruses typically package their geno

135 Double-stranded DNA viruses use ATP-powered molecular mo

136 The assembly of double-stranded DNA viruses, from phages to herpesviruse

137 he portal protein is a key component of many double-stranded DNA viruses, governing capsid assembly a

138 of rhodopsin genes were identified in large double-stranded DNA viruses.

139 igner DNA nanoparticles are constructed from double-stranded DNA with cytosine-rich stick ends (C-mon

140 with the presence of pathogenic anti-dsDNA (double-stranded DNA) antibodies, and provided spontaneou

141 ith similar efficiencies in both single- and double-stranded DNA, 1-methyladenine is preferentially r

142 Herpesviruses are ubiquitous, double-stranded DNA, enveloped viruses that establish li

143 g activities of aTFs for small molecules and double-stranded DNA, here we develop a simple, supersens

144 in which viral RNA genome is converted into double-stranded DNA, is that it is slow and non-processi

145 specifically bound to cGAS independently of double-stranded DNA, resulting in a non-competitive inhi

146 Unlike double-stranded DNA, single-stranded RNA can be spontane

147 Tested with 1k base-pair double-stranded DNA, the SaS nanopore enabled sensing at

148 Coccolithoviruses (EhVs) are large, double-stranded DNA-containing viruses that infect the s

149 pesvirus infection to increase the levels of double-stranded DNA-reactive antibodies at the peak of v

150 NPs finally results in the formation of long double-stranded DNA-RNA (HCR products) -AuNPs.

151 uclease to introduce site-specific breaks in double-stranded DNA.

152 bqp)(2)](2+) with i-motif, G-quadruplex, and double-stranded DNA.

153 olocalizing with cGAS, which is activated by double-stranded DNA.

154 scence quenching to detect unpaired bases in double-stranded DNA.

155 termined positions on the backbone of native double-stranded DNA.

156 racellular innate immune sensor that detects double-stranded DNA.

157 omote extensive and reversible compaction of double-stranded DNA.

158 logously to the nucleosome's organization of double-stranded DNA.

159 sult in the formation of physical defects in double-stranded DNA.

160 le at joint molecule structures and adjacent double-stranded DNA.

161 DSN initiates random 'nicks' on double-stranded-DNA which enable BST to polymerize DNA b

162 the HRP3 PWWP domain in complex with various double-stranded DNAs with/without bound histone peptides

163 ment in HDR between a Cas9 DSB and a plasmid double stranded donor DNA (dsDonor).

164 Silencing is attributed to a 1:1 double stranded (ds) complex that does not fit and canno

165 1 and STAT2 resulting in upregulation of the double stranded (ds)RNA sensor proteins RIG-I and MDA5,

166 Only one strand on a double-stranded (ds) DNA substrate was modified in the r

167 Being guided by an RNA to cleave double-stranded (ds) DNA targets near a short sequence t

168 Hfq is also found in the nucleoid and binds double-stranded (ds) DNA with a slight preference for A-

169 Inter-strand jumping on two double-stranded (ds) DNAs was also observed.

170 9(134-144), as well as anti-nuclear and anti-double-stranded (ds)DNA antibodies that are characterist

171 st innate immune responses against cytosolic double-stranded (ds)DNA arising from genotoxic stress an

172 icative helicase CMG is a closed ring around double-stranded (ds)DNA at origins yet must transition t

173 ambda2/3 in response to challenge with RV or double-stranded (ds)RNA mimic, Poly Inosinic-polycytidyl

174 ng shrimp viruses by using sequence-specific double-stranded (dsRNA) designed to knock down key viral

175 FN responses result from increased levels of double-stranded endogenous Alu RNAs.

176 pendent protein kinase (DNA-PK) requires DNA double-stranded ends for enzymatic activation.

177 until lagging-strand replication creates the double-stranded form.

178 Transcribing and replicating a double-stranded genome require protein modules to unwind

179 hesis protocol, we achieved an unprecedented double-stranded hexagonal cycloarene containing 108 sp(2

180 nd time-dependently colocalized with non-CpG double-stranded immunostimulatory DNA (ISD).

181 lock House virus and Nodamura virus; and the double-stranded L-A virus of yeast, are involved in inte

182 e indicated the contribution of encapsidated double-stranded linear DNA and replication intermediates

183 obilization strategy of probe strands with a double-stranded linker.

184 d DNA template and is programmed by a set of double-stranded linkers that specify pairwise interactio

185 can be induced via HDR with both single and double stranded methylated repair templates.

186 s of ATP/NTP to translocate along and unwind double-stranded nucleic acids.

187 We show that Dvl DIX forms antiparallel, double-stranded oligomers in vitro, and that Dvl in cell

188 t is initiated by the binding and nicking of double-stranded origin of replication by a replication i

189 to insert sulfur into the DNA backbone as a double-stranded phosphorothioate (PT) modification, and

190 ligonucleotides to target PCR-derived linear double-stranded plasmid DNA.

191 aling how these RNases recognize and process double-stranded pre-rRNA.

192 m and Nterm-ACB with RNA hairpins containing double-stranded regions.

193 ry into the nucleus of the host cell, linear double-stranded retroviral DNAs are either integrated in

194 s B virus (HBV) is a unique, tiny, partially double-stranded, reverse-transcribing DNA virus with pro

195 an ADAR2 comprising its deaminase domain and double stranded RNA binding domain 2 (dsRBD2) bound to a

196 st SARS-CoV spike protein and nucleoprotein, double stranded RNA, and RNA probe for spike genes were

197 e gene I (RIG-I)-like receptors detect viral double-stranded RNA (dsRNA) and 5'-triphosphorylated RNA

198 (OAS) are innate immune sensors of cytosolic double-stranded RNA (dsRNA) and play a critical role in

199 of interferon-inducible enzymes that require double-stranded RNA (dsRNA) as a cofactor.

200 The strategy of directly targeting double-stranded RNA (dsRNA) by triplex-formation is rela

201 Immunofluorescence assays (IFA) specific for double-stranded RNA (dsRNA) demonstrated the presence of

202 t to respond to the aberrant accumulation of double-stranded RNA (dsRNA) due to increased sensor leve

203 create enough space to accommodate and bind double-stranded RNA (dsRNA) during unwinding.

204 A protein hub that involves the double-stranded RNA (dsRNA) editing enzyme adenosine dea

205 Double-stranded RNA (dsRNA) exhibits a smooth transition

206 sed of nonenveloped viruses with a segmented double-stranded RNA (dsRNA) genome that replicate in dis

207 sortment is common in viruses with segmented double-stranded RNA (dsRNA) genomes.

208 NA (ADARs) convert adenosines to inosines in double-stranded RNA (dsRNA) in animals.

209 Herein, we show increased levels of double-stranded RNA (dsRNA) in infected bone in a Staphy

210 MDA5-mediated signaling by reducing the MDA5-double-stranded RNA (dsRNA) interaction.

211 to-specific genes was performed by injecting double-stranded RNA (dsRNA) into female Aedes aegypti mo

212 ses, but amplification of viral proteins and double-stranded RNA (dsRNA) is inhibited in infected neu

213 Double-stranded RNA (dsRNA) molecules are used as a nove

214 RNAi-5x was applied either as double-stranded RNA (dsRNA) or RNAi plasmid DNA (dsDNA).

215 a signature of dsRNA sensing, including the double-stranded RNA (dsRNA) receptor DExD/H-Box Helicase

216 n GUVs provide significant protection of the double-stranded RNA (dsRNA) replication intermediate aga

217 The virus is bipartite, containing two double-stranded RNA (dsRNA) segments designated as dsRNA

218 aberrant innate immune responses through the double-stranded RNA (dsRNA) sensor MDA5, unleashing endo

219 ctivate protein kinase R (PKR), a known host double-stranded RNA (dsRNA) sensor.

220 worms bacteria carrying a plasmid expressing double-stranded RNA (dsRNA) targeting a gene of interest

221 gment of the DvSSJ1 gene, the formation of a double-stranded RNA (dsRNA) transcript and siRNAs in tra

222 tudy, we identified a taxon of monosegmented double-stranded RNA (dsRNA) viruses in five planarian sp

223 Endogenous RNA transcription characterizes double-stranded RNA (dsRNA) viruses in the Reoviridae, a

224 Partitiviruses are segmented, multipartite double-stranded RNA (dsRNA) viruses that until recently

225 cription of mitochondrial RNAs that may form double-stranded RNA (dsRNA), as has been observed in mam

226 sensing and binding to viral RNA, including double-stranded RNA (dsRNA), RIG-I and MDA5 undergo cyto

227 stimulation with IFN, but not intracellular double-stranded RNA (dsRNA), was inhibited by RV.

228 erfect RNA duplexes and act as inhibitors of double-stranded RNA (dsRNA)-activated protein kinase (PK

229 ny of these transcripts bind and inhibit the double-stranded RNA (dsRNA)-dependent kinase PKR.

230 granules (avSGs) by regulating activation of double-stranded RNA (dsRNA)-dependent protein kinase R (

231 Parallel analyses with double-stranded RNA (dsRNA)-immunostimulated bees reveal

232 g domain (RBD) that are required for binding double-stranded RNA (dsRNA).

233 s that lead to production of progeny genomic double-stranded RNA (dsRNA).

234 ced by ADARs [adenosine deaminases acting on double-stranded RNA (dsRNA)] together with the endogenou

235 (EDIII) subunit antigen and two adjuvants, a double-stranded RNA (Poly (inosinic:cytidylic acid) (Pol

236 particles (DLPs), while genome replication (double-stranded RNA [dsRNA] synthesis) by VP1 occurs wit

237 IFN pathway, which comprises the sensing of double-stranded RNA and DNA (dsRNA/dsDNA) followed by IF

238 Functional relevance was demonstrated as double-stranded RNA and LL-37 promoted adhesion and tran

239 the capacity of UVB exposure to promote both double-stranded RNA and LL-37 was responsible for the en

240 ryptic transcripts being more prone to cause double-stranded RNA and viral mimicry, we observe low DN

241 C of RdRps from three RNA viruses, i.e. the double-stranded RNA bacteriophage Phi6, and the positive

242 tly increased when larvae were injected with double-stranded RNA bound to CNTs (PAMAM-CNT-dsRNA), com

243 tected in epidermal RNA, which suggests that double-stranded RNA derived from these retroelements may

244 We identified double-stranded RNA derived from tumour cells as an upst

245 Oligoadenylate synthetase 1 (OAS1) binds double-stranded RNA from invading viruses and produces 2

246 The digestion of double-stranded RNA from keratinocytes exposed to UVB bl

247 nucleotide sensing receptor that recognizes double-stranded RNA from viral infection.

248 er RNA viruses.IMPORTANCE The rotavirus (RV) double-stranded RNA genome is replicated and packaged in

249 etic manipulation of the rotavirus segmented double-stranded RNA genome.

250 CE, we discovered a novel plant virus with a double-stranded RNA genome.

251 These interactions are primarily with double-stranded RNA in a non-sequence specific fashion,

252 ound that ZBP1 constitutively bound cellular double-stranded RNA in a Zalpha-dependent manner.

253 The unwinding of double-stranded RNA intermediates is critical for the re

254 ed processing indicate that the synthesis of double-stranded RNA is defective in the absence of G3BP

255 inducible RNA species is reduced, leading to double-stranded RNA ligand sensing by PKR and MDA5; this

256 Endogenous release of type I IFNs with the double-stranded RNA mimetic poly(I:C) likewise produces

257 Small double-stranded RNA molecules can efficiently trigger RN

258 ce (RNAi) is a natural process through which double-stranded RNA molecules can silence the gene carry

259 al, attenuating the cytosolic L-A and Killer double-stranded RNA mycoviruses and protecting meiotic p

260 signaling pathways, either those that sense double-stranded RNA or cytoplasmic DNA that trigger IFN

261 l-like receptor 3 stimulation with poly(I.C) double-stranded RNA or infection with herpes simplex vir

262 ated siRNA loci were most often derived from double-stranded RNA precursors copied from spliced mRNAs

263 ndothelial cells, confirming the role of the double-stranded RNA recognition pathways.

264 Here we show XPO5 pervasively binds to double-stranded RNA regions found in some clustered prim

265 ominant RNA-capsid interaction sites favored double-stranded RNA regions.

266 eplication complexes revealed that the viral double-stranded RNA replication template is coiled insid

267 As that form stable secondary structures and double-stranded RNA targets remains challenging as retro

268 alvi can stably recolonize bees and produce double-stranded RNA to activate RNAi and repress host ge

269 rus (reovirus) is a nonenveloped, segmented, double-stranded RNA virus in the Reoviridae family.

270 The triennial International Double-Stranded RNA Virus Symposium, this year organized

271 Finally, when synthetic double-stranded RNA was detected by OAS3 to induce RNase

272 ch targets minus-strand synthesis to produce double-stranded RNA) when mu1 is knocked down.

273 n of the ISR, by inhibiting the ISR-inducing double-stranded RNA-activated protein kinase or boosting

274 In line with the double-stranded RNA-binding activity of EBP1 in human (H

275 This construct, the DGCR8 core, contains two double-stranded RNA-binding domains (dsRBDs) and a C-ter

276 dividual, a homozygous variant in one of the double-stranded RNA-binding domains (dsRBDs) was identif

277 t RAN translation is highly regulated by the double-stranded RNA-dependent protein kinase (PKR).

278 lated by PRKRA (protein interferon-inducible double-stranded RNA-dependent protein kinase activator A

279 viral antigen 2B and mature virions but not double-stranded RNA.

280 RNA (ADARs) convert adenosine to inosine in double-stranded RNA.

281 d siRNA-directed pUG RNA biogenesis underlie double-stranded-RNA-directed transgenerational epigeneti

282 By mimicking double-stranded RNAs (dsRNAs), the exceptionally abundan

283 nse, mediated by the formation of endogenous double-stranded RNAs (dsRNAs).

284 inly attributed to MDA5 and RIG-I sensing of double-stranded RNAs (dsRNAs).

285 RDR2 converts Pol IV transcripts into double-stranded RNAs and then typically adds an extra un

286 t an effective antiviral response.IMPORTANCE Double-stranded RNAs produced during viral infections se

287 ent RNA polymerase (RdRP), which synthesizes double-stranded RNAs that are sensed by melanoma differe

288 saRNAs are small double-stranded RNAs that enhance target gene expression

289 Using partially double-stranded RNAs, very efficient TATase activity was

290 were found defective in degrading exogenous double-stranded RNAs, which may explain retention of vir

291 ting of RNA to prevent sensing of endogenous double-stranded RNAs.

292 teins bind to origins of replication at many double-stranded sites and also at AT-rich regions where

293 d is greatly stabilized in vitro by specific double-stranded sites of the origin.

294 plexes of the initiator with the single- and double-stranded sites.

295 ces cholesterol synthesis, and inclisiran, a double-stranded small interfering ribonucleic acid that

296 Here we report a deracemization of a racemic double-stranded spiroborate helicate containing a bispor

297 structure that lacks single-stranded loops, double-stranded stems, or junctions.

298 single-stranded RNA substrate but not on the double-stranded substrate.

299 However, there is no requirement for DNA double-stranded termini.

300 ded RNA (dsRNA) demonstrated the presence of double-stranded viral RNA in tonsillar cells.