ライフサイエンスコーパス: double-stranded DNA break

1 double helix and generate an enzyme-mediated double-stranded DNA break.

2 resent at both scissile bonds to stabilize a double-stranded DNA break.

3 ilizing a strand-specific nick rather than a double-stranded DNA break.

4 leading to further processing of the initial double-stranded DNA break.

5 role in determining the response of cells to double stranded DNA breaks.

6 identify SMARCAL1 as a protein recruited to double-stranded DNA breaks.

7 cells through an accumulation of persistent double-stranded DNA breaks.

8 es responsible for homology-driven repair of double-stranded DNA breaks.

9 phosphorylated histone H2AX, an indicator of double-stranded DNA breaks.

10 ad3-related (ATR) kinase to induce transient double-stranded DNA breaks.

11 tivity and might prevent DME from generating double-stranded DNA breaks.

12 nation, which is essential for the repair of double-stranded DNA breaks.

13 e that initiates homologous recombination at double-stranded DNA breaks.

14 nonhomologous end-joining pathways to repair double-stranded DNA breaks.

15 rays and ultraviolet light that can lead to double-stranded DNA breaks.

16 nation, an important mechanism for repair of double-stranded DNA breaks.

17 l DNA replication in egg extracts containing double-stranded DNA breaks.

18 is, which leads to excessive accumulation of double-stranded DNA breaks.

19 maternally or paternally derived and display double-stranded DNA breaks.

20 with, 53BP1 after exposure to agents causing double-stranded DNA breaks.

21 equired in order to increase enzyme-mediated double-stranded DNA breaks.

22 ily by the enzyme and can generate permanent double-stranded DNA breaks.

23 ert processed BER intermediates to permanent double-stranded DNA breaks.

24 Mre11 and Rad50 to coordinate the repair of double-stranded DNA breaks.

25 uring mitosis, meiosis, and in the repair of double-stranded DNA breaks.

26 re deficient in genes required for repair of double-stranded DNA breaks.

27 due to the involvement of ATM in monitoring double-stranded DNA breaks.

28 that are secondary to aberrant responses to double-stranded DNA breaks.

29 athway allows immature thymocytes to survive double-stranded DNA breaks.

30 A2, BRCA1 does not function in the repair of double-stranded DNA breaks.

31 important cellular pathway for the repair of double-stranded DNA breaks.

32 mologous recombination and for the repair of double-stranded DNA breaks.

33 ells revealed the presence of site-specific, double-stranded DNA breaks.

34 base deamination or removal without inducing double-stranded DNA breaks.

35 converting single-stranded DNA lesions into double-stranded DNA breaks.

36 on repair (HRR) enables fault-free repair of double-stranded DNA breaks.

37 ired byproducts and toxicity associated with double-stranded DNA breaks.

38 d versatile genome editing without requiring double-stranded DNA breaks.

39 as ssDNA gaps are transformed into cytotoxic double-stranded DNA breaks.

40 tion but instead increased R-loop levels and double-stranded DNA breaks.

41 ls by inhibiting topoisomerases and inducing double-stranded DNA breaks.

42 gether with experimentally induced telomeric double-stranded DNA breaks.

43 on, and is a major pathway for the repair of double-stranded DNA breaks.

44 us for homology-directed DNA repair (HDR) of double-stranded DNA breaks.

45 sions, small duplications, and generation of double-stranded DNA breaks.

46 Cas9 as an RNA-guided nuclease that creates double-stranded DNA breaks.

47 , suggests sequence capture during repair of double-stranded DNA breaks.

48 ed in homologous recombination and repair of double-stranded DNA breaks.

49 forms distinct foci, and can associate with double-stranded DNA breaks.

50 defective lentiviruses into nuclease-induced double-stranded DNA breaks.

51 ved in the early recognition and response to double-stranded DNA breaks.

52 with other telomeric loci, or non-telomeric double-stranded DNA breaks.

53 ase/nuclease that initiates recombination at double-stranded DNA breaks.

54 ferred DNA and protecting the genome against double-stranded DNA breaks.

55 maximal activity and induced a high ratio of double-stranded DNA breaks.

56 ation of Rad50 foci, which are formed around double-stranded-DNA breaks.

57 striction sites as non-self and introduces a double-stranded DNA break [3].

58 colibactin, a genotoxic molecule(s) causing double-stranded DNA breaks(4) and enhanced colorectal ca

59 mit capture of the second processed end of a double-stranded DNA break, a step which is required for

60 Myc or GpIb alpha overexpression and include double-stranded DNA breaks, altered nuclear size and mor

61 esulted from nuclear entry by Dox, promoting double-stranded DNA breaks and apoptosis.

62 s, probably due to the dramatic induction of double-stranded DNA breaks and chromosomal fragmentation

63 urthermore, these tumors were aneuploid with double-stranded DNA breaks and end-to-end telomere fusio

64 This resistant phenotype produced fewer double-stranded DNA breaks and enhanced a cytostatic res

65 usly we have shown that HCV infection causes double-stranded DNA breaks and enhances the mutation fre

66 ential to insert large DNA fragments without double-stranded DNA breaks and facilitate mutation hotsp

67 sophila, a meiotic checkpoint which monitors double-stranded DNA breaks and involves Drosophila ATR a

68 these BER intermediates can transition into double-stranded DNA breaks and promote genome instabilit

69 Depletion of WRN induced double-stranded DNA breaks and promoted apoptosis and ce

70 various stressors, such as for the repair of double-stranded DNA breaks and protein quality control,

71 that has primarily evolved for the repair of double-stranded DNA breaks and stalled replication forks

72 on resected single-stranded DNA generated at double-stranded DNA breaks and stimulating RAD51 activit

73 ions on the efficacy of CRISPR/Cas9-mediated double-stranded DNA breaks and subsequent DNA repair is

74 NA repair enzyme that recognizes single- and double-stranded DNA breaks and synthesizes chains of pol

75 CD complex, which acts in both the repair of double-stranded DNA breaks and the degradation of bacter

76 ransient, and nucleases generate deleterious double-stranded DNA breaks and uncontrolled mixtures of

77 t during homologous recombination, repair of double stranded DNA breaks, and integron recombination.

78 induced pluripotent stem cells with minimal double-stranded DNA breaks, and collagen type VII protei

79 ed replication forks, insufficient repair of double-stranded DNA breaks, and improper segregation of

80 Finally, GpIbalpha also promotes double-stranded DNA breaks, and induces profound nuclear

81 etabolism, archazolid caused S-phase arrest, double-stranded DNA breaks, and p53 stabilization, leadi

82 These data suggest single- and double-stranded DNA breaks are generated during the cell

83 deletions and sequence replacement with few double-stranded DNA breaks as a strategy that may enable

84 NN, like NRG, attenuated the double-stranded DNA breaks associated with DOXO exposure

85 ene drives are designed to induce a targeted double-stranded DNA break at a wild type allele ('recipi

86 c manner, and is related to a site-specific, double-stranded DNA break at mat1.

87 isiae initiates when Ho endonuclease makes a double-stranded DNA break at the yeast MAT locus.

88 pyogenes (SpCas9) is more active in creating double-stranded DNA breaks at 37 degrees C than at 22 de

89 The identification of blunt-ended double-stranded DNA breaks at the embedded heptamers and

90 germline transcripts and increased levels of double-stranded DNA breaks at the recombination signal s

91 eplacement "footprints" in IgH sequences and double-stranded DNA breaks at V(H) cRSS sites in immatur

92 in phosphorylation site abundance following double stranded DNA breaks, at two distinct loci in the

93 et (UV)-C radiation and reagents that induce double-stranded DNA breaks, but exhibit normal responses

94 s sufficient to stimulate the formation of a double-stranded DNA break by human topoisomerase IIalpha

95 ATM is recruited to double-stranded DNA breaks by a complex of sensor protei

96 d51 are important proteins for the repair of double-stranded DNA breaks by homologous recombination i

97 In diploid eukaryotes, repair of double-stranded DNA breaks by homologous recombination o

98 The error-free repair of double-stranded DNA breaks by homologous recombination r

99 tumours are often deficient in the repair of double-stranded DNA breaks by homologous recombination(8

100 o prevent telomeres from being recognized as double-stranded DNA breaks by sequestering the 3' single

101 s initiated by introduction of site-specific double-stranded DNA breaks by the RAG-1 and RAG-2 protei

102 However, both single-stranded and double-stranded DNA breaks can be labeled by this method

103 air pathway is required to prevent or repair double-stranded DNA breaks caused by defective DNA repli

104 found that some cells within biofilms incur double-stranded DNA breaks caused by endogenous oxidativ

105 of linked loci is limited as multiple nearby double-stranded DNA breaks created by Cas9 routinely res

106 We find that double-stranded DNA breaks created by the R2 endonucleas

107 g cellular metabolism; these lesions include double-stranded DNA breaks, daughter-strand gaps, and DN

108 Cell-cycle arrest induced by double-stranded DNA breaks depends on activation of the

109 Double stranded DNA Breaks (DSB) that occur in highly tr

110 ted T helper 17 cell differentiation through double-stranded DNA break (DSB) and ASC-mediated inflamm

111 ern expected as a consequence of repair of a double-stranded DNA break (DSB) of an unreplicated chrom

112 Impairment of double-stranded DNA break (DSB) repair is essential to m

113 recombination (HR) is a crucial pathway for double-stranded DNA break (DSB) repair.

114 ressing cells during the early stages of the double-stranded DNA break (DSB) response, accelerating a

115 al chromatin organization before and after a double-stranded DNA break (DSB), to estimate the level o

116 he RAG-1 and RAG-2 proteins, which introduce double-stranded DNA breaks (DSB) adjacent to the Ig and

117 ) are ancient selfish elements that catalyze double-stranded DNA breaks (DSB) in a highly specific ma

118 Recognition and repair of double-stranded DNA breaks (DSB) involves the targeted r

119 oci over large chromatin domains surrounding double-stranded DNA breaks (DSB).

120 sitivity specifically to agents that induced double-stranded DNA breaks (DSB).

121 ubiquitin ligase is activated in response to double stranded DNA breaks (DSBs) where it mono-ubiquiti

122 sDNA gaps which converts them into cytotoxic double stranded DNA breaks (DSBs).

123 amages mitochondria, leading to induction of double-stranded DNA breaks (DSBs) and accumulation of ox

124 In mammalian cells, double-stranded DNA breaks (DSBs) are preferentially rep

125 are particularly susceptible to formation of double-stranded DNA breaks (DSBs) arising from physiolog

126 by ATR (ATM and Rad3-related) in response to double-stranded DNA breaks (DSBs) but not to DNA replica

127 Homologous recombination (HR) repairs double-stranded DNA breaks (DSBs) by generating single-s

128 Double-stranded DNA breaks (DSBs) can result in chromoso

129 The activation of ATR-ATRIP in response to double-stranded DNA breaks (DSBs) depends upon ATM in hu

130 J) and homologous recombination (HR), repair double-stranded DNA breaks (DSBs) in all eukaryotes.

131 cent reports show it is enriched at sites of double-stranded DNA breaks (DSBs) in mammalian cells.

132 tein essential for recombinational repair of double-stranded DNA breaks (DSBs) in somatic cells and d

133 participates in the detection of chromosomal double-stranded DNA breaks (DSBs) in this system.

134 e the spatial recruitment of HR factors upon double-stranded DNA breaks (DSBs) induced in human and m

135 and acceptor genomic sequences subjected to double-stranded DNA breaks (DSBs) made by programmable n

136 functionally dicentric chromosome undergoes double-stranded DNA breaks (DSBs) that can be repaired b

137 MRE11, RAD50, NBS1) complex, which processes double-stranded DNA breaks (DSBs) via activation of the

138 a heterodimer of Ku70 and Ku86 that binds to double-stranded DNA breaks (DSBs), activates the catalyt

139 e two master checkpoint kinases activated by double-stranded DNA breaks (DSBs).

140 ions have been implicated in the response to double-stranded DNA breaks (DSBs).

141 f the Rad52 epistasis group of genes, repair double-stranded DNA breaks (DSBs).

142 regions and by the subsequent generation of double-stranded DNA breaks (DSBs).

143 Rad52 and RPA participate in the repair of double-stranded DNA breaks (DSBs).

144 topoisomerase II generates a protein-linked double-stranded DNA break during its catalytic cycle, it

145 eveloped a new approach to study single- and double-stranded DNA breaks during chronic, moderate exci

146 important for the recombinational repair of double-stranded DNA breaks during meiosis.

147 gous recombination compete for the repair of double-stranded DNA breaks during the cell cycle.

148 In Escherichia coli, RecBCD processes double-stranded DNA breaks during the initial stages of

149 Here we show that CRISPR/Cas9-induced double-stranded DNA breaks enrich for cells deficient in

150 utant was shown to have a capacity to repair double-stranded DNA breaks equivalent to wild-type.

151 ctor CtIP helps to initiate the resection of double-stranded DNA breaks for repair by homologous reco

152 In bacterial cells, processing of double-stranded DNA breaks for repair by homologous reco

153 In bacterial cells, processing of double-stranded DNA breaks for repair by homologous reco

154 In bacterial cells, processing of double-stranded DNA breaks for repair by homologous reco

155 AddAB is a helicase-nuclease that processes double-stranded DNA breaks for repair by homologous reco

156 and replication fork restart, prevention of double-stranded DNA break formation, and avoidance of re

157 independent of ATR/ATM checkpoint signaling, double-stranded DNA break formation, and changes in cell

158 p codons or eliminating start codons without double-stranded DNA break formation.

159 s recombination events that are initiated by double-stranded DNA breaks formed prior to replication.

160 non-homologous end-joining (NHEJ) repair of double-stranded DNA breaks generated by Cas9 are much le

161 F, XPC and AP-endonuclease-1), and repair of double-stranded DNA breaks (homologs of BRCA2, XRCC3, KU

162 because AID(+) dividing cells exhibited more double-stranded DNA breaks, IGH class switching, and new

163 e fact that there are two scissile bonds per double-stranded DNA break implies that there are two sit

164 recombination is important for the repair of double-stranded DNA breaks in all organisms.

165 nuclease, which is involved in the repair of double-stranded DNA breaks in Bacillus subtilis.

166 nstrate that DNA intercalating agents induce double-stranded DNA breaks in both immature thymocytes a

167 e analyzed the repair of transposase-induced double-stranded DNA breaks in cells deficient in either

168 Repair of double-stranded DNA breaks in Escherichia coli is initia

169 ded DNA and is required for the rejoining of double-stranded DNA breaks in mammalian cells.

170 otein kinase (DNA-PK) controls the repair of double-stranded DNA breaks in mammalian cells.

171 Although Cas9 efficiently induces double-stranded DNA breaks in the early embryo and male

172 Cas9 can be reprogrammed to create specific double-stranded DNA breaks in the genomes of a variety o

173 20 are colocalized at the gamma-H2AX foci of double-stranded DNA breaks in the nucleus.

174 point mutations in the Ig variable region or double-stranded DNA breaks in the switch region DNA.

175 We generated double-stranded DNA breaks in yeast cells in vivo by exp

176 ions, and H2AX phosphorylation, a marker for double-stranded DNA breaks, in Hus1(neo/neo) and Hus1(ne

177 e)-dependent nucleases used in the repair of double-stranded DNA breaks, including those formed by DP

178 BRCA1 has no equivalent role at chromosomal double-stranded DNA breaks, indicating that tandem dupli

179 initiate recombination between homologs are double-stranded DNA breaks induced during S or G2 of the

180 However, double-stranded DNA break induction by CPT was significa

181 a prominent error-free pathway that repairs double-stranded DNA breaks; instead, EBV-transformed cel

182 Here we introduced double-stranded DNA breaks into the nuclear genome of to

183 The mechanism by which a double-stranded DNA break is produced following collisio

184 rejoining of DNA ends at single-stranded or double-stranded DNA breaks is catalyzed by DNA ligases.

185 In bacteria, the repair of double-stranded DNA breaks is modulated by Chi sequences

186 e are two scissile bonds per enzyme-mediated double-stranded DNA break, it has been assumed that ther

187 cycle progression through mitosis following double-stranded DNA breaks leads to the formation of mic

188 r helicase function, resulting in widespread double-stranded DNA breaks, nuclear swelling and cell de

189 f transposable elements, which suggests that double-stranded DNA breaks occur frequently here.

190 at large-scale, yet previously unrecognized, double-stranded DNA breaks occur normally in early postm

191 oksani et al. examine the impact of a single double-stranded DNA break on replication in the budding

192 e scissile bond is sufficient to stabilize a double-stranded DNA break or whether both drug sites nee

193 on at Ser(92) in response to the presence of double-stranded DNA breaks or DNA replication blocks in

194 se pairs to G-C base pairs without requiring double-stranded DNA breaks or donor DNA templates.

195 ediate genome modification without utilizing double-stranded DNA breaks or exogenous donor DNA as a t

196 antage that it does not require formation of double-stranded DNA breaks or provision of a donor DNA t

197 reaction of topoisomerase II, which creates double-stranded DNA breaks, plays a central role in both

198 (D)J recombinase directly, by monitoring the double-stranded DNA breaks produced in the process of V(

199 During recombinational repair of double-stranded DNA breaks, RAD51 recombinase assembles

200 ade of Mre11, Rad50 and Nbs1/Xrs2) initiates double-stranded DNA break repair and activates the Tel1/

201 Double-stranded DNA break repair and homologous recombin

202 critical role in sister chromatid cohesion, double-stranded DNA break repair and regulation of gene

203 Double-stranded DNA break repair by homologous recombina

204 5%) breakpoint junctions are consistent with double-stranded DNA break repair by nonhomologous end-jo

205 a crucial role in genetic recombination and double-stranded DNA break repair in Archaea, Bacteria, a

206 Homologous recombination and double-stranded DNA break repair in Escherichia coli are

207 omologous recombination (HR) is an essential double-stranded DNA break repair pathway.

208 n of bacterial cells, bacteriophage modulate double-stranded DNA break repair pathways to protect the

209 s a key regulator of DNA replication timing, double-stranded DNA break repair, and replication fork r

210 n to their implications for the mechanism of double-stranded DNA break repair, these observations may

211 A-dependent protein kinase (DNA-PK) mediates double-stranded DNA break repair, V(D)J recombination an

212 , one component of a heterodimer involved in double-stranded DNA break repair.

213 ast DNAs insert into nuclear genomes through double-stranded DNA break repair.

214 luding DNA recombination, transcription, and double-stranded DNA break repair.

215 is a DNA helicase/nuclease that functions in double-stranded DNA break repair.

216 coli, homologous recombination initiated at double-stranded DNA breaks requires the RecBCD enzyme, a

217 AB translocation and hotspot scanning during double-stranded DNA break resection.

218 merase I and II create transient single- and double-stranded DNA breaks, respectively, it has been as

219 ling (TUNEL) were used to detect single- and double-stranded DNA breaks, respectively.

220 parallel with CRISPRi/a, which do not induce double-stranded DNA breaks, revealed that a distinct set

221 component of, or in close proximity to, the double-stranded DNA break-sensing machinery.

222 method, which predicts the extent to which a double-stranded DNA break site will utilize the microhom

223 Unrepaired DNA lesions, such as single- and double-stranded DNA breaks (SSBs and DSBs), and single-s

224 Gmnn(-/-) spermatogonia exhibit more double-stranded DNA breaks than control cells, consisten

225 hat the two regions differ in the density of double-stranded DNA breaks that are generated.

226 ingle-stranded DNA breaks frequently lead to double-stranded DNA breaks that are not rapidly repaired

227 whether cells die via apoptosis by detecting double-stranded DNA breaks that are the result of endonu

228 CRISPR/Cas9 causes double-stranded DNA breaks that can undergo DNA repair e

229 omosome throughout the genome and can induce double-stranded DNA breaks that lead to chromosome trans

230 enesis is secondary to aberrant responses to double-stranded DNA breaks that occur during V(D)J recom

231 rcalating agents reflects their tolerance of double-stranded DNA breaks that occur normally during an

232 nocytes within psoriatic plaques do not have double-stranded DNA breaks, that they have a prolonged c

233 Although fluoroquinolones stabilize double-stranded DNA breaks, the antibacterial thiophenes

234 ough BRCA2 functions to help the cell repair double-stranded DNA breaks, the function of BRCA1 remain

235 horylated H2AX is a characteristic marker of double-stranded DNA breaks, this modification was widely

236 II topoisomerases (TOP2) introduce transient double-stranded DNA breaks through a covalent TOP2-DNA i

237 n in genome stability by promoting repair of double-stranded DNA breaks through homologous recombinat

238 In all domains of life, the resection of double-stranded DNA breaks to form long 3'-ssDNA overhan

239 e ability of a single 1 Gy exposure to cause double stranded DNA breaks (TUNEL assay) was enhanced at

240 aks resulted in the generation of persistent double-stranded DNA breaks was found to be a primary cau

241 gly, CSR induced by staggered but not blunt, double-stranded DNA breaks was impaired by SAMHD1 deplet

242 to the well described Cas9-induced blunt-end double-stranded DNA breaks, we provide evidence for Cas9

243 the BNP-based sunblock significantly reduced double-stranded DNA breaks when compared with a commerci

244 predictably and independent of Cas9-induced double-stranded DNA breaks (which causes substantial ind

245 r growth by causing apoptotic cell death via double-stranded DNA breaks while causing a remodeling of

246 fork stalling, we suggest that formation of double-stranded DNA breaks within the Ytel sequences mig