ライフサイエンスコーパス: down-regulate

1 entified on day 28 (63% up-regulated and 37% down-regulated).

2 of proteins responsible for lipogenesis was down regulated.

3 expression of gluconeogenic genes were found down regulated.

4 ch cell division, growth, and metabolism are down-regulated.

5 olling chromatin silencing were collectively down-regulated.

6 , while genome-wide cancer-related genes are down-regulated.

7 tant neuronal marker during development, was down-regulated.

8 the CS8 with 2073 genes up-regulated and 140 down-regulated.

9 r HC, with flv2 and flv4 expression strongly down-regulated.

10 , of which 118 were up-regulated and 68 were down-regulated.

11 ignment defects in these cells when they are down-regulated.

12 n levels of APLNR in NPC tissues were indeed down-regulated.

13 nase, and starch phosphorylases were largely down-regulated.

14 Similar changes are seen when C3PO is down-regulated.

15 s (DEGs) vs. fresh-frozen, 98% of which were down-regulated.

16 ire set of photosystem genes was prominently down-regulated.

17 tal of 66 differentially expressed genes (25 down-regulated, 41 up-regulated) were identified in heat

18 of 1041 differentially expressed genes (282 down-regulated, 759 up-regulated) were identified in the

19 ity to modulate host protein trafficking and down-regulate a number of cell surface receptors to enha

20 proliferation and migration in vitro, and in down-regulating airway inflammation, T helper 2/T helper

21 ere were 363 unigenes up-regulated and 1,117 down-regulated among all ecotypes examined during the ex

22 MLL4 expression is aberrantly down-regulated and BA homeostasis is disrupted in choles

23 We also found that AURKA is down-regulated and primary cilia formation is enhanced w

24 C(4)-related genes were down-regulated and subsequently fully expressed upon dro

25 screened including 112 up-regulated and 175 down-regulated and they belong to lipids and lipid-like

26 e durian pulp revealed that 15 proteins were down-regulated and three other proteins were up-regulate

27 s of 56 and 22 protein-coding genes that are down-regulated and up-regulated in pin1Delta cells, resp

28 sal midline Nestin(+) radial glia (dmNes+RG) down-regulate apical polarity proteins, including Crumbs

29 We further demonstrate that MAOA is down-regulated as a result of IL-6/IL-6R/STAT3 signallin

30 gly, UBR5, and to a lesser degree UBR4, were down-regulated as cellular demand for antibody expressio

31 ormation genes (needed for translation) were down-regulated as compared with unrestricted DO.

32 en receptor (ER)-beta, which upon activation down-regulated ASM proliferation, implicating an importa

33 as a relapse biomarker, whose expression was down regulated at a relapse compared to remission in MOG

34 Although Lmna was the only DEG down-regulated at 1 week of age, we identified 730 and 1

35 east 2-fold in CLL, while 701 fragments were down-regulated at least 2-fold.

36 n that occurs when cortical contractility is down-regulated at the junctions between those neighbor c

37 on that does not bind nucleotide and thereby down-regulates ATP hydrolysis of the complex.

38 Suppression of AMPK/aak-2 by NRF2/SKN-1 down-regulates autophagy during prolonged oxidative stre

39 or kinase 1 (HPK1) and demonstrate that HPK1 down-regulates AXL and decreases its half-life.

40 Mammals achieve immunological tolerance by down-regulating both major histocompatibility complex pa

41 ll differentially expressed escape genes are down-regulated but most differentially expressed inactiv

42 is has revealed that the pattern of pathways down regulated by CM03 in the parental MIA PaCa-2 cell l

43 exts, we found that the gene GDPGP1/mcp-1 is down-regulated by a variety of stresses.

44 from diverse substrates whose activities are down-regulated by acylation but are required for biofilm

45 or part of the default-mode network (DMN) is down-regulated by both normal ageing and Alzheimer's dis

46 a signature panel of 107 genes predominantly down-regulated by DEP exposure.

47 e analysis showed that most of the genes are down-regulated by ethylene in shoots, and a DNA binding

48 ncRNA that is consistently and significantly down-regulated by IGF1 signaling by a post-transcription

49 culture showed that LINC00346 expression is down-regulated by p53.

50 fected by inhibition of mTOR, unless RHA was down-regulated by siRNA.

51 expression and HA accumulation by AoSMCs are down-regulated by the metabolic sensor SIRT1.

52 knockdown experiments, we found that BCL2 is down-regulated by TNF inhibition.

53 s (RPPA) suggests that Fraxini substantially down-regulates c-Myc expression in Hep3B cells.

54 ression of a minimal PDZ-RhoGEF fragment can down-regulate cAMP signaling, suggesting that this effec

55 By down-regulating candidate deubiquitinases that are eithe

56 Notably, the inability of Nef to down-regulate CD3 from infected T cells distinguishes HI

57 or shRNA delivery using CD30 RNA aptamers to down-regulate CD30(+) Th17 cells and can be developed as

58 -interacting protein ATP6V0C plays a role in down-regulating cell-surface expression of tetherin and

59 ism for SAMHD1 catalysis, reveals how SAMHD1 down-regulates cellular dNTP and modulates the efficacy

60 ted chamber-enriched gene, and in Cacna1g, a down-regulated conduction system-specific gene.

61 that IL-22 significantly decreased GJIC and down-regulated Cx43 expression in HaCaT cells.

62 activating the JNK signaling pathway, which down-regulates Cx43 expression; this process is a possib

63 for these events, we blocked N/C increase by down-regulating cyclin/Cdk1 to arrest early cell cycles

64 ired in Areg(-/-) mice, and recombinant AREG down-regulated Cyp7a1 mRNA in hepatocytes.

65 Major surface glycoprotein also down regulated Dectin-1 receptor messenger ribonucleic a

66 e two frameshift mutant lines and found many down-regulated DEGs enriched in photosynthesis, heme, te

67 h these terms, nine up-regulated DEGs and 32 down-regulated DEGs showed the same direction of effect

68 Down-regulated DEGs were enriched for genes involved in

69 al immortal prostate cells, whereas Ad.mda-7 down-regulates DICER in multiple cancer cells including

70 genes related to antimicrobial function were down-regulated during ACS compared to VOC.

71 t genes related to erythroid maturation were down-regulated during acute infections, whereas immune r

72 l a significant number of small GTPases were down-regulated during adipogenesis.

73 ls at the BBB, then demonstrated that DHH is down-regulated during experimental autoimmune encephalom

74 O-GlcNAc signaling is down-regulated during macrophage proinflammatory activat

75 In BRAF-mutant melanoma, Dnmt1 was down-regulated during response to B-Raf and MEK inhibiti

76 a class of lipids, acyl-carnitines, as being down-regulated during Wolbachia infection.

77 encing enhanced miR193a and Cathepsin L, but down-regulated dynamin expressions.

78 strength of relevant TFs, and cooperatively down-regulate EPAS1 expression.

79 is-stimulated eicosanoid and cytokine storm, down-regulated ER stress genes, and promoted macrophage

80 ms to simultaneously and dynamically up- and down-regulate expression of 2 sets of genes.

81 ORS, MIXED and TFs all displayed significant down-regulated expression (q.value < 0.1) and correlated

82 se markers, Grm4, encoding mGluR4, displayed down-regulated expression in the caudate putamen and NAc

83 LPS down-regulated expression of alphaSMA, PDGFbetaR, transf

84 CA-KRAS, CA-NRAS, and CA-BRAF down-regulated expression of endoplasmic reticulum (ER)

85 Down-regulated expression of FXR plays an important role

86 RNA-Seq analysis demonstrates down-regulated expression of genes involved in cell adhe

87 In addition, we provide evidence that down-regulated expression of miR-338-5p in AD is regulat

88 f individual miRNAs in B-cell lymphoma cells down-regulated expression of PRMT5, CYCLIN D1, and c-MYC

89 Mechanistically, loss or inhibition of MLK3 down-regulates expression of a prolyl-isomerase, Ppia, w

90 PGE(2) down-regulates expression of p53 by increasing expressio

91 We down-regulated EZH2 and TET2 in AML cell lines and asses

92 glutathione and coenzyme A, which, together, down-regulated ferroptosis.

93 ting specificity, and monophosphoryl lipid A down-regulated fibrogenic markers, but elicited very wea

94 topoisomerase-1 inhibitor camptothecin (CPT) down-regulated FLIP in pancreatic cancer models and enha

95 osis induced by alphaDR5-NPs was enhanced by down-regulating FLIP, a key modulator of death receptor-

96 HDAC4 and HDAC5 were down-regulated following SPS, and these changes were als

97 The results indicate that fungal infection down-regulated FOXA2 expression in airway epithelial cel

98 cription that is reduced by inhibiting EGFR, down-regulating FUS, or expressing FUS mutated in the EG

99 Xenotransplantation of tumor cells with down-regulated FZD3 levels originating from melanomas ca

100 for transcription factors, which can up- or down-regulate gene expression depending upon environment

101 quencing by RNA-Seq revealed JUP as the most down-regulated gene among 21 skin fragility-associated g

102 by simply analyzing functions of the up and down regulated genes, and thus this work has provided a

103 ARgamma-dependent adipocyte differentiation, down-regulate genes involved in lipid metabolism, block

104 cells up-regulate immune response genes and down-regulate genes involved in proliferation, metabolis

105 dated by performing QPCR on selected up- and down-regulated genes (COL10A1, COL11A1, FBLN, FERMT1, FN

106 ndothelial cells, our analysis revealed most down-regulated genes associated with cellular response t

107 after acute RE we identified 866 up- and 936 down-regulated genes at the expression level, with 270 (

108 n, and oxidative phosphorylation, as well as down-regulated genes governing DNA damage repair and up-

109 At 1 month, the down-regulated genes included those involved in oxidativ

110 Elevated proportion of down-regulated genes involved in apoptosis, NFKB signali

111 We found that down-regulated genes preferentially contained NF-Y-bindi

112 DomA exposure at 2 dpf down-regulated genes required for maintaining myelin str

113 mice with Clostridia, but not Desulfovibrio, down-regulated genes that control lipid absorption and r

114 s anticipated, an abundance of significantly down-regulated genes was apparent at 168 hpi, reflecting

115 Among these, 638 up-regulated and 1,242 down-regulated genes were classified as CAMTA6-dependent

116 functional clusters where populations of the down-regulated genes were highly distinct.

117 lopment reflected TLS formation, whereas the down-regulated genes were involved in metabolic processe

118 For the down-regulated genes, several were categorized in gene o

119 aromatic amino acid biosynthesis genes among down-regulated genes.

120 egulator, MYC-associated factor X (MAX), and down-regulates genes by binding to E-boxes.

121 tes several phospholipid biosynthetic genes, down-regulated GPC1 expression at the mRNA and protein l

122 code proteins that preserve their ability to down-regulate HIFalpha.

123 gulator, USF2, whose depletion significantly down-regulated HOXA9 expression and impaired MLLr leukem

124 Our results suggests that both peptides also down-regulate hSGLT2 and hSGLT3 via the same pathway.

125 In sum, by up- and down-regulating I(NaP) and KCC2, the calpain-mediated pr

126 ular Ca(2+) levels and activated PP2A, which down-regulated IGF signaling and promoted the quiescent

127 ng through Galphaq protein-coupled receptors down-regulates IK(Na) , which increases the excitability

128 Many cell wall related genes are down regulated in mus-3 mul-1.

129 enes involved in gemcitabine sensitivity are down regulated in the resistant line upon CM03 treatment

130 pilosebaceous unit of normal human skin, is down-regulated in acne.

131 The down-regulated in adenoma (DRA) protein, encoded by SLC2

132 terestingly, we find that Gish expression is down-regulated in aging guts and that increasing Gish ac

133 up-regulated in one subtype of a cancer but down-regulated in another, making overall associations b

134 (ABRE) element within their promoters, were down-regulated in AtVIP2 overexpressor lines.

135 and cuticle biosynthesis are constitutively down-regulated in ccc1 mutants, and the cell walls of th

136 including VEGFA and BDNF were significantly down-regulated in cells from depressed subjects.

137 rom distinct genes of pre-tRNA(His), and are down-regulated in CLL 3- to 5-fold vs. normal B cells.

138 e the most representative module genes, both down-regulated in COPD cases.

139 Further, SMAD/TGF-beta1 signaling was down-regulated in CSF plasmablasts/plasma cells.

140 tures (such as synaptotagmins) were commonly down-regulated in CTE, CTE/AD, and AD.

141 , the expression of CXCL14 was significantly down-regulated in epidermal keratinocytes with age.

142 Other glossy genes tended to be down-regulated in glossy mutants; by contrast stress-res

143 s zinc finger protein 42), to be selectively down-regulated in HCC tumors.

144 play a pivotal role in memory function, were down-regulated in head trauma-related disorders.

145 charides and related regulatory systems, was down-regulated in host-like media when compared to MHB.

146 tumor suppressor FBW7 is commonly mutated or down-regulated in human LSCC, and oncogenic KRasG12D act

147 y m(6) A methyltransferase, is significantly down-regulated in human sorafenib-resistant hepatocellul

148 Because HEXIM1 is often down-regulated in human triple-negative breast cancer (T

149 including in response to stress, were up- or down-regulated in in vitro potato plantlets.

150 that Neuropeptide Y (NPY) was significantly down-regulated in insulin-resistant vs. insulin-sensitiv

151 gly up-regulated in the absence of LRRK2 and down-regulated in its presence.

152 amps, being highly up-regulated in liver and down-regulated in muscle and fat.

153 a widely distributed nuclear lncRNA that is down-regulated in NAFLD.

154 ulate oxidative stress in the lean state are down-regulated in obesity as a consequence of inflammato

155 s (Lgr5, Olfm4, Smoc2, Msi1, and Ascl2) were down-regulated in organoids incubated with etomoxir, an

156 MMR proteins were also down-regulated in patient-derived xenografts and tumor s

157 e expression of angiogenin was significantly down-regulated in patients with inflammatory bowel disea

158 ged miR in cells where PLCbeta1 or C3PO were down-regulated in PC12 cells and find substantial differ

159 ich encodes a stathmin family protein and is down-regulated in PD brains, as a key regulator function

160 ophoblast and that ETC protein expression is down-regulated in placentas of infants with intrauterine

161 sed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues.

162 These six genes were also significantly down-regulated in pre-malignant adjacent tissues compare

163 ive sphingolipids such as ceramide were also down-regulated in primary AML cells.

164 We show that MAOA is down-regulated in primary NPC tissues and its down-regul

165 e regulator of adipocyte differentiation, is down-regulated in RCC and shows a differential expressio

166 tandem duplicates are significantly up- and down-regulated in response to anthracnose infection, whe

167 eus, and plasma membrane, were either up- or down-regulated in response to US.

168 Moreover, miR-26a is down-regulated in serum exosomes and islets of obese mic

169 Cancer Genome Atlas and found that MBNL1 was down-regulated in several common cancers.

170 as highly expressed in CCA human tumors, was down-regulated in SOX17-transduced CCA cells.

171 oreover, TMIGD1 is shown to be progressively down-regulated in sporadic human CRC, and its downregula

172 ene modules - connected sets of genes up- or down-regulated in subsets of samples.

173 sporter across membranes, were significantly down-regulated in the colon of antibiotic-treated mice.

174 essed genes (DEGs), 566 up-regulated and 235 down-regulated in the genotypes with exserted stigma.

175 me studies have demonstrated that miR-27b is down-regulated in the oral specimens of patients sufferi

176 ere enriched for biotic stress responses and down-regulated in the pae9-2 mutant, including PAD3 and

177 including circFndc3b which is significantly down-regulated in the post-MI hearts.

178 In contrast, inflammation-related genes were down-regulated in the RV and while oxidative phosphoryla

179 EHD2 expression itself was down-regulated in the visceral fat of two obese mouse mo

180 and enzymes of chlorophyll biosynthesis were down-regulated in the yellow leaf tissue.

181 artial hepatectomy, we found that DN-DBC1 is down-regulated in vivo during regeneration.

182 ASE1) and expansin homologous genes were all down-regulated, indicating their potential contribution

183 inhibits SP1-mediated gene transcription to down-regulate INPP5A, a protein that is highly abundant

184 nd reduced in human cancers, but how PTEN is down-regulated is not fully understood.

185 lation of TLR4 by LPS activates NF-kappaB to down-regulate ITPR3 expression in human cholangiocytes.

186 symbol along with the wish to up-regulate or down-regulate its expression.

187 Hypermethylation of the TET2 gene down-regulated its transcription.

188 recruit the cytohesin Arf-GEF Steppke, which down-regulates junctional tension and facilitates tissue

189 y termed antifibrotic microRNAs [AF-miRNAs]) down-regulate key structural, signaling, and remodeling

190 ates C-terminal Src kinase (CSK) and thereby down-regulates kinases involved in proximal TCR activati

191 also provide evidence that prolonged hypoxia down-regulates kindlin-2 expression, leading to spindle

192 We conclude that iron down-regulates leptin by decreasing CREB glycosylation,

193 Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-kappaB acti

194 Another network comprising 4 down-regulated lncRNAs and 8 down-regulated metallothion

195 the gamma-secretase inhibitor dibenzazepine down-regulated LRP5/6 and FZD10 expression.

196 In addition, sorafenib was found to down-regulate major histocompatibility complex class I e

197 ssory protein that enhances pathogenicity by down-regulating major histocompatibility class I (MHC-I)

198 For example, NR2F2-depletion down-regulated many genes in U2OS cells, consistent with

199 In addition, we found that EBV infection can down-regulate MAOA expression in both pre-malignant and

200 antibodies lack potency and the capacity to down-regulate Met.

201 rk comprising 4 down-regulated lncRNAs and 8 down-regulated metallothionein-family genes are signific

202 We find that tumor cells down regulated MHC-II molecules, suggesting that the dow

203 the most highly elevated miR in hepatic SHP-down-regulated mice with elevated hepatic BA levels.

204 egulated circRNA (circARID1A) via sponging a down-regulated microRNA (miR-204-3p) in human neuronal c

205 Interestingly, HIV-1 infection down-regulated miR-125b expression concurrent with up-re

206 V infection of hepatocytes transcriptionally down-regulates miR-181c expression through CCAAT/enhance

207 A regulatory aspects in HCSC, we compiled 15 down-regulated miRNA and their validated and predicted u

208 8, miR-3127-5p, miR-1305, miR-1288-3p) and 2 down-regulated miRNAs (miR30a-5p, miR-145-5p) which are

209 Among the top 5 up- and down-regulated miRNAs, down-regulation of miR-548aq-3p i

210 rowth factor receptor (EGFR)/BRAF inhibition down-regulates mismatch repair (MMR) and homologous reco

211 on stress, ultraconserved microRNAs (miRNAs) down-regulate MISTR1(NDUFA4) followed by replacement wit

212 r results indicated a role for HIF-1alpha in down-regulating mitochondrial metabolism while concomita

213 idin-4-yl]formamido)propanoate, NV18.1, that down-regulate MR1 from the cell surface and retain MR1 m

214 Many down-regulated mRNAs, which are mostly responsible for n

215 Our results provide evidence that MZF1 down-regulates Mtor expression in pristane-induced plasm

216 h activated CDC42-associated kinase (ACK) in down-regulating mTOR expression and promoting neuronal d

217 id may provide a new therapeutic approach to down-regulate mTORC1 signaling.

218 ObRb), highly expressed in the intestine, to down-regulate MTP.

219 LITAF overexpression down-regulated NEDD4-2 in cardiomyocytes and HEK cells.

220 Down-regulating neurons co-encoded both possible goals a

221 Action-selection signals emerged earliest in down-regulating neurons of premotor cortex, arguing for

222 L cells, attenuated protein translation, and down-regulated NF-kappaB- and STAT-dependent transcripti

223 hibits nephrin-induced actin polymerization, down-regulates nonmuscle myosin IIA activity, and destab

224 n of Notch2 antisense oligonucleotides (ASO) down-regulates Notch2 and the Notch target genes Hes-rel

225 upregulated and Bcl-2 and Bcl-xL levels were down-regulated on treatment with PRF/BCP.

226 561 DEGs, including 413 up-regulated and 148 down-regulated or not transcribed genes, were simultaneo

227 lbaTraDIS can identify genes which are up or down regulated, or inactivated, between multiple conditi

228 (NAM) and nicotinamide riboside (NR), while down-regulating other NAD biosynthetic pathways.

229 Other nearby genes were also down-regulated, over a region of ~500 kb on chromosome 3

230 PecT down-regulates PCWDE and the T3SS by repressing the expr

231 ment of aHSCs inhibited their proliferation, down-regulated PDGFbetaR, alphaSMA, TGFbetaR1, Col1alpha

232 ERK phosphorylation at Thr(799) to partially down-regulate PERK-eIF2alpha signaling while avoiding wi

233 ates the mTORC2/Akt pathway and subsequently down-regulates Phlpp1 phosphatase, allowing for phosphor

234 Additionally we find that beside Blimp1, down-regulated phospho-Smad159 levels also distinguishes

235 wild-type LonP1 in the siblings' fibroblasts down-regulated phosphoE1alpha.

236 Our results confirm that rice universally down-regulates photosynthesis in response to both abioti

237 eria and fungi deploy effector proteins that down-regulate plant defense responses and reprogram plan

238 Here, we show that down-regulating PLCbeta1 or reducing its cytosolic popul

239 Down-regulating POP2 specifically increases TIM protein

240 d that both M2 and M13 (at 1.0 mug/mL) could down-regulate pro-inflammatory factors (TNF-alpha, IL-1b

241 cluster suppressed in vitro angiogenesis and down-regulated pro-angiogenic proteins expression.

242 The most significantly down-regulated processes in DS mesodermal progenitors we

243 ng molecule that signals the other strain to down-regulate production of its own, orthogonal signalin

244 The floR mutation is highly pleiotropic, down-regulating production of gas vesicles, carbapenem a

245 onor-derived MDSCs treated recipients showed down-regulated proinflammatory cytokines.

246 ral precursor cell-expressed developmentally down-regulated protein 4).

247 (2) decreased intracellular phosphate, which down-regulated PRPP synthetase activity.

248 e reductions in PTEN, the ability of PRL2 to down-regulate PTEN provides a biochemical basis for its

249 ve PRL2 substrate and demonstrated that PRL2 down-regulates PTEN by dephosphorylating PTEN at Y336, t

250 llustrated 18 and 14 miRNAs that are up- and down-regulated, respectively, in FIR-responsive CAD ECFC

251 lls phosphate homeostasis genes are strongly down-regulated, resulting in an effectively phosphate-li

252 Overexpression of SPARC down-regulated RGS4, a negative regulator of beta-cell M

253 44-3p expression, indicating that miR-144-3p down-regulates RXFP1 in IPF lung fibroblasts by targetin

254 2), which is increased in obese individuals, down-regulated SIRT1 levels, leading to elevated acetyl-

255 RDI treatments down-regulated some terpene genes, which indicates that

256 XW7), a subunit of the SCF ubiquitin ligase, down-regulates spindle assembly 6 homolog (HsSAS-6), a k

257 ividual chromosomes provides the feedback to down-regulate Spo11 activity, thereby revealing an addit

258 In the target cells, miR-274 down-regulates Sprouty (Sty) through a targeting sequenc

259 e cell cycle regulators were correspondingly down-regulated, such as Ccna2 and Ranbp1.

260 ecrease of H3K14ac in the 5' end of the GCN5 down-regulated targets, it also led to an increase of H3

261 rs substantially up-regulated HIF1-alpha and down-regulated Tbeta-4, although hemocyte counts were un

262 HIV-1 Nef does not down-regulate the overall level of TIM-1 expression, but

263 heterodimer, which reduced PI3K activity and down-regulated the activation of proteins that require p

264 LPS down-regulated the expression of cMyb, a transcription f

265 This event down-regulated the expression of tight junction markers,

266 reactive oxygen species (ROS) production and down-regulated the gene expression of inflammation marke

267 RT3 overexpression increased miR-34a levels, down-regulated the miR-34a target genes CDK4/6, and caus

268 Furthermore, Slit2/Robo1 binding down-regulates the Arl4A-Robo1 interaction in vivo, thus

269 us calcium treatment, Rcr1 ubiquitinates and down-regulates the chitin synthase Chs3.

270 equires a feedforward circuit whereby Ikaros down-regulates the expression of Myc.

271 ant to complement and cationic peptides, and down-regulates the inflammatory response by engaging sig

272 ne signaling, HFSCs enter deep quiescence by down-regulating the cell cycle and metabolism while up-r

273 nces release of the virus from host cells by down-regulating the cell-surface expression of the host

274 r ribonucleoproteins by post-translationally down-regulating the eIF4E inhibitory protein 4E-BP1.

275 as exhibited promising antitumor activity by down-regulating the expression of vital antiapoptotic ce

276 regression by blocking protein synthesis and down-regulating the Wnt signaling pathway.

277 When these genes were up- or down-regulated, the biliatresone effect on spheroids was

278 tress responses and growth regulation, which down-regulate their target genes.

279 Here we show that CFTR modulators down regulate this exaggerated proinflammatory response

280 n of cholesterol and terpenoid syntheses and down-regulated those involved in glycerophospholipid met

281 o beta-cell proliferation and simultaneously down-regulated those networks required for other process

282 hich the transcriptional activity of FlrA is down-regulated through a negative feedback loop.

283 We previously reported that iron down-regulates transcription of the leptin gene by incre

284 STAT3 inhibition down regulated transcriptional targets of STAT3 in these

285 e of the most highly (approximately 68-fold) down-regulated transcripts in ASH1L knockout cells.

286 lar enlargement during slowed cell cycles by down-regulating translation capacity.

287 USP18 down-regulates type I interferon signaling by blocking t

288 in iodine efflux during oxidative stress are down-regulated under increasing pCO(2) , suggesting that

289 sis, as well as photosynthetic activity were down-regulated under the same conditions.

290 LAC2 expression was significantly down-regulated under water deficit and posttranscription

291 es (DEGs), including 62 up-regulated and 298 down-regulated unigenes.

292 etween AnxA8 and Wnt signalling, as both are down-regulated upon fenretinide (FR)-mediated RPE transd

293 reas negative regulators of the pathway were down-regulated upon NANOG expression.

294 tributes to the antiviral response either by down-regulating various metabolic pathways important for

295 bloodstream form of T. brucei, we show that down-regulated vtRNA levels impair trans-spliced mRNA pr

296 ifferentially expressed genes, either up- or down-regulated, were involved in responses to stimuli an

297 e cochlea on day 1 (40% up-regulated and 60% down-regulated), whereas only 49 DEGs were identified on

298 Aquaporin (Aqp) 11 was also potently down-regulated, whereas Aqp5/AQP5 expression persisted,

299 ssion of many fewer genes, 77% of which were down-regulated with no significant enrichment of KEGG Pa

300 ly, a putative target of RORbeta, Thsd7a, is down-regulated without RORbeta, and Thsd7a knock-out alo