ライフサイエンスコーパス: down-regulation

1 ith multiple hypotheses of bottom-up and top-down regulation.

2 ein levels defines gene up-regulation versus down-regulation.

3 is reduced after myofibroblast-specific Cx43 down-regulation.

4 ing HGF binding to Met and inducing receptor down-regulation.

5 trafficking via early and late endosomes to down-regulation.

6 he mechanism involved in NDRG1-mediated EGFR down-regulation.

7 e nutrient transporters, which aids in their down-regulation.

8 were studied to ascertain biasing away from down-regulation.

9 ly 100 kb near all telomeres that escape DSB down-regulation.

10 primary target of the cytokine-mediated ZnT8 down-regulation.

11 -stimulated direct GR-dependent gene up- and down-regulation.

12 t internalize and therefore does not undergo down-regulation.

13 red podocytes identified significant exocyst down-regulation.

14 nd signal-dependent receptor endocytosis and down-regulation.

15 he Nef:MHC-I:AP-1 complex required for MHC-I down-regulation.

16 ssociated genes, only MND1 showed consistent down-regulation across three NR2F2-depleted ALT+ cell li

17 may act on microbiome diversity through top-down regulation analogous to predators in non-microbial

18 1, both of which bind the URE, prevents Pu.1 down-regulation and blocks terminal erythroid differenti

19 he outcomes were accompanied by CDK6 protein down-regulation and G(0)-G(1) cell cycle arrest.

20 ces selective chemosensitization due to MRP3 down-regulation and subsequent intracellular drug accumu

21 relationship is associated to an effect (up/down-regulation) and to the mechanism (e.g. binding, pho

22 oxisomal membrane protein 70 (PMP70) (modest down-regulation), and acyl-CoA oxidase 1 (ACOX1).

23 Interaction among oncogenic miR-31, EGLN3 down-regulation, and inflammation was also documented in

24 hanistic link between skeletal loading, SOST down-regulation, and intense bone deposition.

25 n floral volatiles as was observed for PhC3H down regulation, but eugenol and isoeugenol emissions we

26 Top-down regulation by the parasitoid and bottom-up regulati

27 However, the mechanistic basis for SERINC5 down-regulation by Nef remains elusive.

28 d G-protein coupling but away from long-term down-regulation can be achieved.

29 These results show that MHC-I down-regulation can induce either NK cell tolerance or k

30 Finally, CLDN-2 down-regulation contributed to RHOA activation and smoot

31 trulation-associated gene profile, and Nodal down-regulation correlated with a preneurulation-associa

32 y correlated in human HCC tissues, and Aldob down-regulation coupled with p-Akt up-regulation predict

33 However, miR-125b down-regulation depended on HIV-1 reverse transcription

34 Moreover, miR-508-3p down-regulation, due to promoter hypermethylation, was d

35 s were identified that had >log2-fold up- or down-regulation during the extreme heat event (e.g., DRE

36 cell, it would be an appropriate target for down-regulation during the transition from growth to qui

37 own-regulated in primary NPC tissues and its down-regulation enhances the migration of NPC cells.

38 XR, ameliorated atherosclerosis, whereas Src down-regulation exacerbated it.

39 l incorporation of SERINC5 by triggering its down-regulation from the producer cell membrane through

40 n important signaling molecule whose up- and down-regulation have specific biological consequences.

41 erase reverse transcriptase component (TERT) down-regulation, immediately after endoderm differentiat

42 N1 expression in transfected cells, and USP6 down-regulation impedes focal GluN1 distribution at post

43 n on striated muscles, including a transient down regulation in dystrophin gene transcription in the

44 not activated in cell death induced by AEBP1 down regulation in PTEN-deficient (U87MG and U138MG) cel

45 c miRNAs, including miR-221 and miR-320, for down-regulation in a cancer-selective manner.

46 These two genes were up-regulation and down-regulation in all husk related tissues, respectivel

47 re, we investigated the consequences of SKIP down-regulation in AML primary cells and the effects of

48 These results indicate that SKIP down-regulation in AML reduces SK activity and ceramide

49 r calbindin and a mitosis marker p-H3 showed down-regulation in ganglionic eminences.

50 ved in Toll-like receptor signaling, and its down-regulation in human monocytes attenuated the LPS-in

51 Notably, miR-125b down-regulation in infected cells was not due to reduced

52 PTEN (PTEN-del) can be modeled through Pten-down-regulation in mouse organoids.

53 of depression imaging phenotypes track gene down-regulation in postmortem cortical samples of patien

54 CE1) siRNA complexes we show effective BACE1 down-regulation in the brain without toxicity and inflam

55 ing thymocyte selection, followed by massive down-regulation in the periphery.

56 Here, we show that Klf5 down-regulation in VSMCs is correlated with rupture of a

57 h auxin-induced up-regulation (DR and IR) or down-regulation (IR) was correlated with differential bi

58 Its down-regulation is a promising therapeutic strategy for

59 this is the first study to show that CBFA2T3 down-regulation is both necessary and sufficient for enh

60 at, in FMRP-deficient cortical neurons, mRNA down-regulation is caused by elevated degradation and is

61 cently confirmed in skeletal muscle, and its down-regulation is linked to reduced muscle mass and fun

62 een achieved in recent years, precise H(2) S down-regulation is still challenging.

63 creased expression of eIF5a elicited by Klf5 down-regulation leads to mitochondrial fission and exces

64 n regulating MEIS1 expression, and that this down-regulation may contribute to MYC-driven development

65 ese results indicate that postero-medial DMN down-regulation may not be specific to neurodegenerative

66 lds viable parasites, but is associated with down regulation of both PfEBA165 and an adjacent invasio

67 iration rates to temperature, implying a top-down regulation of carbon loss, perhaps reflecting the h

68 h the induction of BCL6 with the concomitant down regulation of COX-2.

69 f the xenograft tissues revealed significant down regulation of desmoplastic reaction, SHH, Gli-1, MU

70 l systems mediating attention orienting, top-down regulation of emotions, and motor execution.

71 Down regulation of endogenous PhC3H transcript resulted

72 ng factor that reflected the degree of up or down regulation of genes encoding a reaction, identified

73 nals of both inter-guild competition and top-down regulation of herbivores by predators.

74 o elevated IL-1beta and IL-17 since targeted down regulation of HIF-1alpha via short interfering RNA

75 lation with Fusarium graminearum, led to the down regulation of key flavonoid and hydroxycinnamic aci

76 x was decreased to normal, together with the down regulation of mRNA expressions of Collagen I and tr

77 Down regulation of PhHCT transcript did not have as larg

78 In addition, MR-409 induced a down regulation of the gene and protein expression of pi

79 Although down regulation of the transcription factor AP-1 is high

80 sis revealed upregulation of 6,919 genes and down-regulation of 2,695 genes in leaf during the infect

81 y of CeO(2) NPs at 3 mg/plant induced marked down-regulation of a number of amino acids (threonine, t

82 translational level, we uncovered sustained down-regulation of a set of 5'-terminal oligopyrimidine

83 d by gain of E protein function leads to the down-regulation of a transcriptional network important f

84 2 and SARS-CoV-2 leads to the exhaustion and down-regulation of ACE2.

85 Interestingly, down-regulation of adenosine deaminase-related growth fa

86 ding up-regulation of nutrient transporters, down-regulation of adhesion molecules and tumor suppress

87 MitoQ prevented down-regulation of adiponectin and GLUT 4 and increases

88 Despite a neural-specific down-regulation of adr-2 during development, the majorit

89 upted by small interfering RNA (siRNA)-based down-regulation of an actin regulator, by pharmacologica

90 Further, down-regulation of AtPAM16L affected seed germination, e

91 ization of mitochondrial membrane potential, down-regulation of Bcl-2 expression and increase of Bax

92 A-1 and H type 2 antigen), along with marked down-regulation of beta-1,3-galactosyltransferase (B3GAL

93 n-loop, form-deprivation (diffusers)-induced down-regulation of BMP gene expression, and 3) early, tr

94 and KCNN4 were under-expressed, indicating a down-regulation of both excitability and glycolysis.

95 Down-regulation of both strands of miR-30a and miR-145 r

96 e populations in breast cancer cells whereas down-regulation of BRCA1 resulted in significant increas

97 Experimental down-regulation of Bsnd in the parental mouse strain phe

98 ion-translation feedback loop (TTFL), causes down-regulation of c-MYC, and mutation of Bmal1, which a

99 llular Ca(2+) signaling machinery, including down-regulation of Ca(v)1.2 channels and up-regulation o

100 poptosis due to the lack of LTB(4) -mediated down-regulation of cAMP, subsequent failure to induce De

101 le in mediating neutrophil apoptosis via the down-regulation of cAMP.

102 o THC-gelatin in adolescence resulted in the down-regulation of cannabinoid 1 receptors (CB(1)Rs) in

103 Among them, the down-regulation of CAPN10 tv3 was confirmed as an indepe

104 microarray analysis of bladder RNA revealed down-regulation of CAV1, CAV2, and CAV3 gene transcripti

105 ylyl cyclase is necessary and sufficient for down-regulation of Cb1 receptors induced by 4 Hz stimula

106 Down-regulation of CD44/CD44v8-10 impaired cystine uptak

107 nal IR in SIRP-alpha(mut) occurred alongside down-regulation of CD47 and thrombospondin-1, which are

108 s in the up-regulation of E-cadherin and the down-regulation of CDC42.

109 a and embryonic stem cells in which distinct down-regulation of cell cycle-related genes was observed

110 ere also shared between crosses and included down-regulation of cellular processes and genetic inform

111 Gene therapy by expression constructs or down-regulation of certain genes has shown great potenti

112 as well as up-regulation of MHC class I and down-regulation of checkpoint regulator PD-L1 on the can

113 n APAP-induced liver damage were mediated by down-regulation of CHOP at a transcriptional and post-tr

114 Consequently, a widespread down-regulation of chromatin accessibility occurs at a l

115 ic for dpERK versus ERK is required for both down-regulation of Cic and stabilizing phosphorylated ER

116 Down-regulation of CitPH1 and CitPH5 is associated with

117 hed oxygen-glucose deprivation (OGD)-induced down-regulation of claudin-5 mRNA and protein abundance

118 S lung treated with SIL, without significant down-regulation of connective tissue or transforming gro

119 or increasing osteoclastogenesis through the down-regulation of COX2.

120 Mechanistically, we show that down-regulation of CRT results in mitochondrial Ca2+ ove

121 Furthermore, the IL-22-induced down-regulation of Cx43 expression mediated by the JNK s

122 T from N/C increase, arguing that N/C-guided down-regulation of cyclin/Cdk1 is sufficient for genome

123 KLF7 knockdown also results in the down-regulation of Discs Large MAGUK Scaffold Protein 3

124 2s displayed an increase in Cathepsin L, but down-regulation of dynamin expressions and disorganizati

125 IHC confirmed the down-regulation of E-cadherin (CDH1) and up-regulation o

126 files of splenic C/EBPbeta(-/-) DCs showed a down-regulation of E2F cell cycle target genes and assoc

127 suggesting a role for MIG6 in NDRG1-mediated down-regulation of EGFR.

128 Down-regulation of either exporter affected the subcellu

129 ) resulted in an epithelial-like morphology, down-regulation of EMT characteristics, and loss of canc

130 The selective and coordinated down-regulation of energy production genes in schizophre

131 control and stress conditions, and included down-regulation of environmental information processing,

132 sting focal adhesions is associated with the down-regulation of existing focal adhesions and associat

133 upposed to be the driver in PTC development, down-regulation of expression should contribute to the l

134 Down-regulation of EZH2 or TET2 expression inhibited apo

135 miR-211-mediated down-regulation of Ezrin leads to Ca(2+) influx resultin

136 racellular lysophospholipids that results in down-regulation of flagellin expression by Salmonella Th

137 oplasmic reticulum (ER) stress in NAFLD, and down-regulation of FLRL2 resulted in the opposite effect

138 YAP deficiency led to the down-regulation of FOXD1.

139 Down-regulation of FZD3 abrogated growth, colony-forming

140 Together, our data indicate that down-regulation of GDPGP1/mcp-1 and consequent loss of n

141 pression in DT algae, however, was extensive down-regulation of gene expression associated with diver

142 mechanisms operating in concert with massive down-regulation of gene expression controlling numerous

143 EtOH consumption led to a marked down-regulation of genes encoding digestive and xenobiot

144 nonical PRC1 in the skin leads to widespread down-regulation of genes involved in cell adhesion and c

145 regulation of genes related to apoptosis and down-regulation of genes involved in cell cycle and lipi

146 m Pi*Z-overexpressing mice had steatosis and down-regulation of genes involved in lipid secretion.

147 d that Bccip deletion caused an overwhelming down-regulation of genes involved in mitotic cell divisi

148 The latter was evidenced by down-regulation of genes involved in oxidative phosphory

149 n cells with limited spreading, resulting in down-regulation of genes involved in the G2/M cycle and

150 ote stem cell proliferation and survival and down-regulation of genes that promote differentiation.

151 sed TdDof expression was correlated with the down-regulation of genes whose orthologs have been impli

152 Down-regulation of GLI transcription factors also decrea

153 , indicating that reduced SOX2 expression or down-regulation of GLI transcription factors may be effe

154 Down-regulation of GLI transcriptional factors (GLI1 or

155 the re-availability of glucose leads to the down-regulation of gluconeogenesis and the activation of

156 rane proteins and has been implicated in the down-regulation of growth factor signaling, thereby exhi

157 This includes down-regulation of growth hormone receptor (GHR) and of

158 NMIIB-KD cells display down-regulation of Gsc and Serpinb2, which is strikingly

159 we now show that it is also responsible for down-regulation of HER3 upon treatment with IgG 95.

160 Down-regulation of HEXIM1 locks P-TEFb in the Hsp90 comp

161 hway, PHD3 silencing in ccRCC cells leads to down-regulation of HIF-2alpha protein and mRNA.

162 erase II (Pol II)-associated Gdown1 leads to down-regulation of highly expressed genes involved in pl

163 usly unappreciated process of HIV-1-mediated down-regulation of host antiviral proteins, both of whic

164 gical and experimental evidence for parasite down-regulation of host immunity and immunopathology, in

165 s thaliana lines with altered lignin through down-regulation of hydroxycinnamoyl CoA:shikimate/quinat

166 OIR-induced down-regulation of Igf1r was mediated at least partly by

167 for the resolution of the airway pathology, down-regulation of ILC2s and mucus production in asthma.

168 52 using a single-stranded RNA mimic induced down-regulation of immune regulator Z-DNA binding protei

169 RNA interference (RNAi) of SE51385 prevented down-regulation of immune responses at a late stage (> 2

170 er, we find that lifespan-extending systemic down-regulation of insulin signaling results in improved

171 Down-regulation of intraflagellar transport-88, a protei

172 onses, and improved stroke outcomes, whereas down-regulation of IRF4 led to increased IRF5 expression

173 Down-regulation of IRF5 signaling by siRNA or CKO result

174 a unique phenotype in aHSCs associated with down-regulation of key fibrogenic mechanisms and thus ma

175 expression and chromatin accessibility, with down-regulation of L4 and up-regulation of L5 genes, sug

176 Mechanistically, down-regulation of LAMP1 or LAMP2 increased exosome rele

177 /or composition in transgenic plants through down-regulation of lignin biosynthetic enzymes can induc

178 n factors AP-1 and NF-kappaB, leading to the down-regulation of LINE-1 promoter activity.

179 involved in recycling but also result in the down-regulation of many vacuole membrane proteins to sup

180 Down-regulation of MBNL1 led to increased tumorigenic an

181 Down-regulation of MBNL1 predicted poor overall survival

182 of differentiation, whereas DUSP10-mediated down-regulation of mean ERK activity promotes and stabil

183 Down-regulation of MEIS1 promotes the maturation of oxid

184 cardiomyocyte metabolism and that the normal down-regulation of MEIS1 with age underlies a gradual sw

185 ression and activity are associated with the down-regulation of MEIS1, a HOX-family transcription fac

186 For the first time, down-regulation of membrane-associated antigen following

187 CMA specifically reversed Nef-mediated down-regulation of MHC-I, but not CD4, and cells treated

188 y inhibit primary tumor growth via long-term down-regulation of miR-21 in tumors and increase in bios

189 After establishment of the down-regulation of miR-548aq-3p by FIR in CAD ECFCs, we

190 This study suggests the down-regulation of miR-548aq-3p by FIR may contribute to

191 ong the top 5 up- and down-regulated miRNAs, down-regulation of miR-548aq-3p in CAD ECFCs after FIR t

192 Down-regulation of miR-548aq-3p was correlated with the

193 DPDG0s displayed down-regulation of miR193a, but upregulation of nephrin

194 Down-regulation of miR397b activity increased LAC2 expre

195 ed to disease-resistance, showed significant down-regulation of miR399 and up-regulation of miR482 in

196 Atrophy was associated with the down-regulation of mitochondrial transcripts and protein

197 in RNA splicing, inhibition resulted in the down-regulation of more than 400 essential parasite gene

198 ndity and longevity were attributable to the down-regulation of MpNa(v) by RNAi.

199 NA-sequencing analysis identified systematic down-regulation of multiple mitochondrial respiration-re

200 ant inhibition of tumor size and significant down-regulation of Nanog-targeted genes, which are assoc

201 demethylation spreading and can be linked to down-regulation of neighboring genes.

202 BS) exposure, and TROY knockdown also led to down-regulation of NF-kappaB.

203 The down-regulation of Notch 1 and Jagged 1 and loss of thei

204 the Sox17 mutant, likely as a consequence of down-regulation of NOTCH signaling.

205 We found that KRAS depletion led to down-regulation of NRF2 and its targets NQO1 (NAD(P)H qu

206 w that dysfunctional mitochondria, linked to down-regulation of nuclear-encoded mitochondrial oxidati

207 RNA-sequencing analysis revealed significant down-regulation of only five genes in adult thrb (-/-) r

208 Down-regulation of OsWAKL21.2 attenuates LipA-mediated i

209 (namely, p-rpS6-S235/S236) and a concomitant down-regulation of p-Akt1/2 (namely, p-Akt1-S473 and p-A

210 Pembrolizumab induced down-regulation of PD-1 expression on lymphocytes in per

211 ition during vernalization in A. alpina, the down-regulation of PEP1 likely increases GA sensitivity,

212 ved fluorescence analysis shows that extreme down-regulation of photosystem II activity along with di

213 ion and was mediated through transcriptional down-regulation of PIM1 kinase that in turn phosphorylat

214 The down-regulation of proteins in frozen durian pulps indic

215 Collectively, our study revealed that down-regulation of pSMAD2/3, beta-catenin, and MMPs and

216 Overexpression of SIRT4 in cells causes down-regulation of PTEN.

217 that absence of ETO2 in mice interferes with down-regulation of PU.1 and GATA2 in the fetal liver, im

218 r, the mechanisms controlling expression and down-regulation of Pu.1 during early erythropoiesis have

219 epigenetic changes, protein aggregation, and down-regulation of quality control mechanisms are all ha

220 Finally, we show that signal-dependent down-regulation of RAG gene expression in CD4(+)CD8(+) t

221 proved urine concentration and prevented the down-regulation of renal AQP-2 protein expression in mic

222 inhibitor LY-294002 abolished SPARC-induced down-regulation of RGS4.

223 The importance of down-regulation of Runx1 and Pu.1 in erythropoiesis is f

224 e RB-deficient cells in part by opposing the down-regulation of S-phase kinase-associated protein 2 (

225 Down-regulation of SAF with siRNA treatment increases ca

226 These results show that down-regulation of SERINC5 and subsequent enhancement of

227 dimerization-defective Nef mutants, whereas down-regulation of SERINC5 from the membrane of transfec

228 CB1 blockade resulted in down-regulation of several miRs in ATMs, including the m

229 expression when grown in culture, including down-regulation of signature microglial genes.

230 anscription factor with YRPW motif 1 (Hey1), down-regulation of Six2, and unscheduled activation of W

231 orectal cancer data set analysis showed that down-regulation of SMPD1 was associated with resistance

232 In addition, the down-regulation of SNAT2 by the ER antagonist fulvestran

233 sociated with gemcitabine resistance whereas down-regulation of SOX2 sensitizes pancreatic cancer cel

234 r the onset of T2D, up-regulation of AAs and down-regulation of sphingolipids and acyl-alkyl-glycerop

235 Further, this down-regulation of SPI-1 genes depends on the master reg

236 The down-regulation of synaptic GluRIIA subunits by nuclear

237 We demonstrate down-regulation of SYNJ1 transcript in a subset of spora

238 untreated mice, and this was accompanied by down-regulation of systemic anaphylaxis mediators such a

239 reduction of interferon type I activity, and down-regulation of T-cell transcripts associated with ch

240 Here, we examine long-term, agonist-promoted down-regulation of TAS2R14 expression because tachyphyla

241 ve domain of the cochlear duct, resulting in down-regulation of Tead gene targets.

242 Significant down-regulation of terminal differentiation (FLG and FLG

243 Moreover, removal or down-regulation of TERT expression in mTert (+/+) and hu

244 hil elastase and proteinase 3 and subsequent down-regulation of the complement receptor C5aR.

245 ctile myosin pulses and involves RhoGEF3 and down-regulation of the Crumbs complex by the E3 ubiquiti

246 Increased DNA damage or down-regulation of the cytoplasmic exonuclease TREX1 enh

247 Hence, cytokine-induced down-regulation of the ER ZnT8 level promotes adaptive U

248 xpression of activated STAT3 and resulted in down-regulation of the expression of matrix metalloprote

249 Besides, Biz1 can arrest the cell cycle by down-regulation of the gene encoding a second b-cyclin C

250 h allowed reversible, theophylline-dependent down-regulation of the GFP reporter gene in a dose- and

251 e mechanisms mediating the glucose-dependent down-regulation of the gluconeogenic transcription facto

252 ngiocarcinoma metastasis is characterized by down-regulation of the Golgi alpha-mannosidase I coding

253 Consistent with the down-regulation of the hepatic CL pathway, IT surgery pr

254 e concentration in the colon correlated with down-regulation of the host SLC7A2 transporter.

255 validated by quantitative RT-PCR, indicated down-regulation of the hypoxia-associated dosR regulon,

256 uman sebaceous organoid model GATA6-mediated down-regulation of the infundibular differentiation prog

257 ion of genes involved in stress response and down-regulation of the MalaS7 allergen-encoding genes.

258 er, achieving dynamic and autonomous up- and down-regulation of the metabolic modules of interest sim

259 Here we report that down-regulation of the POP2 deadenylase, a key component

260 f the persistent sodium current (I(NaP)) and down-regulation of the potassium/chloride extruder KCC2

261 ogenesis in response to IVIg-FUS include the down-regulation of the proinflammatory cytokine TNF-alph

262 48 hypermethylation in PD is associated with down-regulation of the SLC7A11 gene and show this is con

263 scriptional activation, etc.) causing the up/down-regulation of the target entity.

264 onal categories, together with an additional down-regulation of the translational proteins by 5%.

265 pancreatic CD8+ T cells specifically exhibit down-regulation of the very-long-chain acyl-CoA dehydrog

266 This leads to down-regulation of the WRC and reorganization of the act

267 suppression of PHIP resulted in significant down-regulation of these focal adhesion proteins, along

268 also provides an inherent mechanism for the down-regulation of these inflammasomes by autophagy.

269 Down-regulation of these oxidative processes by ABA may

270 egulated by extracellular magnesium and that down-regulation of this transporter decreases glucose-st

271 R-99a-5p and miR-125a-5p, both implicated in down-regulation of TNFalpha.

272 Knockout of MaTAR25 results in down-regulation of Tns1 leading to a reorganization of t

273 fits are achieved by a reduced food take and down-regulation of transcription of pivotal genes respon

274 Cellular stress response leading to down-regulation of transcription, translation, and energ

275 strongly correlated with concomitant global down-regulation of transcription-and that this can be re

276 tch to C-lignin formation was accompanied by down-regulation of transcripts encoding functional caffe

277 Such nutritional starvation leads to down-regulation of tRNA nuclear import and nearly comple

278 ells of regressing hyaloid vessels underwent down-regulation of two structurally related E-26 transfo

279 coli (EHEC) to d-serine (d-Ser) resulted in down-regulation of type 3 secretion system-dependent col

280 Down-regulation of vacuole membrane proteins is initiate

281 t-negative VAV3 constructs or shRNA-mediated down-regulation of VAV3 expression in breast cancer cell

282 of S. aureus linked to persistent infection: down-regulation of virulence genes and reduced hemolysis

283 -sulfotransferase-1/Chst-14 (D4ST-1/Chst-14) down-regulation on spinal cord regeneration in larval an

284 Down-regulation or epigenetic silencing of HML-2 env res

285 We show that either CAPN1 down-regulation or its chemical inhibition dramatically

286 Many cancers exhibit down-regulation or loss of miR-34a, and synthetic miR-34

287 s to speculate that DUSP6-mediated ERK pulse down-regulation promotes initiation of differentiation,

288 virus type 1 (HTLV-1) expression, while YY1 down-regulation reduces HTLV-1 expression.

289 ed in the Antimycin A-treated worms, and its down-regulation rescued the muscle damage, suggesting th

290 rmacological inhibitors of Nef-induced MHC-I down-regulation restore the adaptive immune response to

291 Cohesin down-regulation restored normal replication fork rates i

292 verexpressed in SCLC cell lines and that its down-regulation results in various metabolic and cellula

293 an index VC, also associated with ccr2/ccr5 down-regulation, suggesting that the phenotype is herita

294 ion on trophoblast cell podosomes, and ACTN4 down-regulation suppressed the E-cadherin-induced cell i

295 hat Nef homodimers are important for SERINC5 down-regulation, trafficking to late endosomes, and excl

296 basal cells with pulsatile ERK activity, and down-regulation was linked to the onset of differentiati

297 expression is well studied, a mechanism for down-regulation when K(+) levels are restored has not be

298 s not cleaved but over-activated under AEBP1 down regulation which leads to the synthesis of PAR in t

299 stin-mediated internalization and subsequent down-regulation with chronic exposure to most agonists.

300 Linking ex vivo gene down-regulation with in vivo neuroimaging, we find that