ライフサイエンスコーパス: downregulate

1 0 (ratio 1.97), while CCL22 (ratio 0.65) was downregulated.

2 e innate immune inhibitor IL-37 was strongly downregulated.

3 rase and Serine-glyoxylate transferase, were downregulated.

4 upregulated, and two (PHF15 and PRDM10) were downregulated.

5 in which MerTK expression was conditionally downregulated.

6 most genes are paused and transcriptionally downregulated.

7 Acan), whereas MMP13 expression was slightly downregulated.

8 erminals, where Kv1.2 potassium channels are downregulated.

9 significant change, with the majority being downregulated.

10 tified 36 differentially expressed genes (26 downregulated, 10 upregulated) involved in skeletal syst

11 that 18 miRNAs were significantly altered (1 downregulated 4 up and 13 downregulated; p < 0.05) in MD

12 One of the genes most highly downregulated (~4.8 fold) in Src-1/-2 dKO fetal lungs en

13 ite as a host-derived signal and responds by downregulating a proinflammatory factor (T3SS1), thus en

14 PTEN dephosphorylates and downregulates Abi1 in breast cancer cells.

15 ion and metastasis via dephosphorylating and downregulating Abi1.

16 Compared with control, SO downregulated ACACA, INSIG1, and DGAT1, whereas FO downr

17 gulated ACACA, INSIG1, and DGAT1, whereas FO downregulated ACACA, PPARGC1, LPIN1 and FABP3 on day 63,

18 ruses suggests that SARS-CoV-2 infection may downregulate ACE2, leading to toxic overaccumulation of

19 As chronic stress downregulates adult hippocampal neurogenesis (AHN) in ma

20 Anandamide (AEA) content was downregulated after repeated seizures, and pharmacologic

21 RAH directly binds to the promoters of genes downregulated after SARRAH silencing via RNA-DNA triple

22 y upregulated, while viral latency genes are downregulated ahead of expression of the viral latent-to

23 SMCs suppressed the synthetic phenotype and downregulated Akt1/mTOR signaling.

24 Pi downregulated alphaKlotho, which also independently impa

25 c expression arrests arbuscule branching and downregulates AM-responsive genes, even in the absence o

26 The most differentially expressed genes (153 downregulated and 60 upregulated) were identified betwee

27 adjusted p < 0.05); most of these genes were downregulated and co-expressed in a gene network related

28 , many gene expression pathways were broadly downregulated and subdermal fat showed pronounced inflam

29 Expression of IFIT1 and MX2 was downregulated and upregulated in cGAS KO and TREX1 KO T

30 lear factor 4alpha circuit in hepatocytes to downregulate ApoM.

31 a subset of aortic endothelial cells with a downregulated arterial signature and a predicted lineage

32 Klotho is downregulated as part of the aging process.

33 find that coupling among ependymal cells is downregulated as postnatal development proceeds but incr

34 rferon (IFN) signaling was transcriptionally downregulated, as measured by significantly decreased mR

35 infection or when Bsr-d1 was knocked out or downregulated, as occurs in bsr-d1 plants upon infection

36 igh levels in arrested tracheoblasts and are downregulated at mitotic re-entry.

37 Furthermore, CPLX3 expression was downregulated at night compared to the day in WT cones b

38 led that the increased osteoclast number was downregulated at the end of the early stage of rapid pal

39 e showed that left atrial ETV1 expression is downregulated at the RNA and protein levels in murine pr

40 scriptional Bax, cytochrome-c and Apaf-1 and downregulated Bcl-2), whereas caspase-9 and -3 expressio

41 Further evaluation showed that GW296115 downregulates BRSK2-driven phosphorylation and downstrea

42 in-associated genes MYC, CCAT1 and TP63 were downregulated by A-485.

43 olutionary conserved lncRNA Sarrah, which is downregulated by aging, as a regulator of cardiomyocyte

44 t in human disease, where PTEN and FOXA1 are downregulated by allelic loss and site-specific DNA hype

45 Whereas SlFAD2-1 and SlFAD2-2 are downregulated by biotic stress, the majority of divergen

46 atrix stiffness-repressed transcript that is downregulated by collagen density and reduced in the bre

47 miR-147 was also downregulated by directly incubating the macrophages wit

48 d gap junction between pericytes and ECs are downregulated by EP-4 and EP-1-dependent mechanisms, lea

49 Among these, 291 and 138 were up and downregulated by GB infestation, respectively.

50 evel and anaphylactic activity of IgE may be downregulated by glycan-specific IgG anti-IgE autoantibo

51 xpressed genes, 286 were upregulated and 124 downregulated by mCD40L versus sCD40L.

52 ximately 50% of the genes that are initially downregulated by PRMT5 inhibition, suggesting that the i

53 , the specific HR protein Rad51 was severely downregulated by the combination via two mechanisms: p53

54 itive MCC cells, the expression of NDRG1 was downregulated by the MCPyV early gene, as T antigen knoc

55 nd ONE HELIX PROTEIN1 transcript levels were downregulated by up to 90%, and GFP protein levels by 95

56 ditive effect on RUNX1 expression, which was downregulated by VEGF modulation.

57 In addition to its ability to downregulate c-MYC and directly inhibit tumor cell proli

58 pathway (SAPK) and its effector, MAPK Sty1, downregulates CAR assembly in S. pombe when its integrit

59 E6 downregulates caspase-dependent pathway through the degr

60 genesis, cell proliferation, and invasion by downregulating caveolin 1 (CAV1) that plays a pivotal an

61 In vitro FTY720 treatment downregulated CCR7 on Y. enterocolitica-infected bone ma

62 cessory protein Vpu enhances viral spread by downregulating CD4 and BST-2/tetherin on the surface of

63 ranscriptomic analyses revealed that low dox downregulated cell cycle genes while high dox upregulate

64 This SIVgsn Vpu interacted with human BST-2, downregulated cell surface human BST-2 expression, and f

65 In vitro, selumetinib downregulated cellular and membrane levels of PD-L1 in t

66 tin and several actin-related proteins to be downregulated, confirming a role for MKL1 as a transcrip

67 the mTORC1/ribosomal protein S6 pathway and downregulated constitutive expression of the antiapoptot

68 ing activity, whereas pioglitazone failed to downregulate Cxcl12 in BM adipocytes.

69 The intracellular protein SOCS1 is known to downregulate cytokine signaling by inhibiting the JAK-ST

70 nstrated that inhibition of STAT6 activation downregulates cytokine production and induces cell-cycle

71 edded in a risk haplotype that progressively downregulates DAP1 transcription in immune cells.

72 gulated DEGs of the mPFC in D1-RNB mice, and downregulated DEGs of the mPFC in D2-RNB mice.

73 ther microglia core genes were substantially downregulated during pathologies.

74 rmed the therapeutic effects of berberine in downregulating DUX4 protein expression, inhibiting muscl

75 unctional gene expression, respectively, and downregulating EC proliferation-related genes.

76 ed cell death ligand-1 (PD-L1) expression by downregulating EGFR signaling.

77 The ability of each Vpu clone to downregulate endogenous CD4 and tetherin was quantified

78 , which involves the delivery of siRNAs that downregulate endogenous genes to confer resistance.

79 asorelaxation by increasing nitric oxide and downregulating endothelin-1 (ET-1) production, has been

80 nd CCPM-BIDEN-AP compromised angiogenesis by downregulating epithelial-mesenchymal transition and ang

81 itor treatment decreased NRG1 expression and downregulated ERBB3 while re-activating pAkt T308, sugge

82 tastatic sites, where soft microenvironments downregulate estrogen receptor expression and upregulate

83 nhancing the formation of type H vessels and downregulating exosomal miR-214-3p.

84 In all models tested, KDOBA67 treatment downregulated expression of a network of transcription f

85 ver, in sorted tumor cell populations, PADI4 downregulated expression of master transcription factors

86 5 oncoprotein suppressed immune responses by downregulating expression of major histocompatibility co

87 ese two genes, with the CTNNB1 S45F mutation downregulating expression of RUNX3, thus providing addit

88 ressive complex 2 (PRC2), is responsible for downregulating FBP1 in liver and kidney cancer cells.

89 itamin D(3) [1,25(OH)(2)-D(3)] significantly downregulated FcepsilonRI at the protein and mRNA levels

90 enerally overlooked in fear, is critical for downregulating fear when novel predictions about upcomin

91 ), a SNARE regulator at ribbon synapses, was downregulated fivefold in the mutant cones.

92 BEC production of versican was significantly downregulated following RSV infection.

93 A total of 407 DEGs (254 upregulated and 153 downregulated) from non-treatment studies and 547 DEGs (

94 tudies and 547 DEGs (133 upregulated and 414 downregulated) from treatment studies were isolated.

95 aberrantly hypermethylated and significantly downregulated gene in PC.

96 gulated in these embryos, including the most downregulated gene nsdhl.

97 cupancy data show that BRD4 enriches at many downregulated genes (including the master coactivators P

98 d in the innate immune response, whereas the downregulated genes contribute to the cellular catabolis

99 HFpEF-specific downregulated genes engaged endoplasmic reticulum stress

100 genes in UF, and 2,560 upregulated and 1,762 downregulated genes in RF under fungus inoculation.

101 Results showed 4,845 upregulated and 4,720 downregulated genes in UF, and 2,560 upregulated and 1,7

102 At different time-points, SO and FO downregulated genes related to synthesis and intracellul

103 nificant difference was observed in a set of downregulated genes that is mainly related to translatio

104 CSCs depleted of PAF1 downregulated genes that regulate stem cell features (Fl

105 man lung cancer cell line H1299 reveals that downregulated genes upon ZZEF1 depletion are specificall

106 Downregulated genes were associated with metabolic, apop

107 aled 1,584 co-upregulated genes and 1,280 co-downregulated genes, including many implicated in cancer

108 dity adjustment altered pathways enriched in downregulated genes.

109 Positively weighted (downregulated) genes were enriched for neuronal, specifi

110 ression analysis also revealed that the most downregulated group of correlated genes was enriched for

111 stitutions at this site (S151D) dramatically downregulate heat shock responses, a result conserved wi

112 ogether, these results suggest that Cdk1 can downregulate Hsp70 function through phosphorylation of t

113 echanisms by which SIVgsn71 Vpu binds to and downregulates human or GSN BST-2, may help to explain th

114 d caspase-2 as the antagonistic caspase that downregulates IFN-I production.

115 Conversely, furin knockdown downregulated IGF1R-beta and p-STAT3 (Tyr705) expression

116 ocytes showed that VR23 not only effectively downregulates IL-6 but also inhibits cell migration.

117 TPR1 (confirmed by luciferase assay) and was downregulated in AF atrial cardiomyocytes; microRNA-26a

118 lator of G protein-coupled receptors that is downregulated in aggressive human prostate tumors.

119 FA2H and ALOXE3) products were significantly downregulated in both AD and psoriasis (FDR < 0.05).

120 This miR was downregulated in both ED groups (ie, ED and RGED).

121 We found that TFEB is downregulated in both human and mouse aortic aneurysm le

122 e identified lncRNA 1810058I24Rik, which was downregulated in both human and murine myeloid cells exp

123 al neurons were enriched in DEGs of the mPFC downregulated in both NAc D1- and D2-RNB mice.

124 s significantly hypermethylated in blood and downregulated in brain tissue from individuals with WS.

125 miR-127 is downregulated in breast cancer, where it has been shown

126 DRAIC is a 1.7 kb spliced long noncoding RNA downregulated in castration-resistant advanced prostate

127 The expression of IL-17RD is downregulated in certain solid tumors, which has led to

128 in the normal human colon but significantly downregulated in colon adenocarcinoma.

129 We discovered that MDFI is up- and MDFIC downregulated in colorectal tumors.

130 that the HUSH component, MPP8 is frequently downregulated in diverse cancers and that its depletion

131 ng metabolic stress-induced compensation but downregulated in dysfunctional type 2 diabetic (T2D) hum

132 Wnt signaling is downregulated in embryonal rhabdomyosarcoma (ERMS) and c

133 ector phospho-myosin light chain (pMLC) were downregulated in endothelial cells by severe hypoxia.

134 We show that ERRFI1 is selectively downregulated in ERalpha-positive breast cancers and bre

135 In vitro, hsa_circ_0001445 was downregulated in extracellular vesicles secreted by huma

136 th, inflammation, and tuft cell markers were downregulated in fat-1 mice in response to EtOH, while d

137 Th17 cell differentiation was downregulated in galectin-9-deficient T cells, and this

138 demonstrates that several of these genes are downregulated in GBM, potentially through epigenetic sil

139 h), both pheromone and opioid signaling were downregulated in gpa-3 mutants.

140 cting proteins, GSK3alpha and GSK3beta, were downregulated in Het mice, whereas the levels of PDE4B a

141 phate synthesis/electron transport, pathways downregulated in HFrEF.

142 ound that enteric NCC express LAMR, which is downregulated in human and murine HSCR.

143 MiR-30e-3p was downregulated in human and rat HCCs, and its downregulat

144 Additionally, TFEB is mislocalized and downregulated in human cells expressing GGGGCC repeats a

145 expressed in the gastrointestinal tract and downregulated in human colon tumors.

146 In addition, expression of miR-1185-1 was downregulated in human colorectal cancer tissues, wherea

147 that all but one of the piRNAs examined are downregulated in leprosy skin lesions.

148 We found that Rig-G was frequently downregulated in lung cancer tissues and cell lines, and

149 P. chabaudi chabaudi AS-infected mice and is downregulated in Malat1(-/-) Th1 and Th2 cells.

150 We show that edited CYb mRNA is downregulated in mammalian bloodstream forms (BSF) at th

151 ptophan and kynurenic acid were consistently downregulated in MDD patients, regardless of antidepress

152 ndreds of mRNAs that were selectively up- or downregulated in MNs.

153 ertrophy-promoting protein that we showed is downregulated in multiple mouse models of cancer cachexi

154 y by which microtubule-sliding can be up- or downregulated in neurons to control neurite outgrowth, a

155 Plasma miR-181a-5p was significantly downregulated in non-progressive patients after FOLFIRIN

156 CLDN1 and CLMP expression were downregulated in nonresponding hairdressers and patients

157 n eye development and phototransduction were downregulated in oil-exposed larvae, with an increased o

158 antly upregulated in SlLHP1b RNAi fruits and downregulated in overexpressing fruits compared with wil

159 icated that the expression of miR-522-3p was downregulated in paclitaxel-resistant cells.

160 In addition, DUOX was significantly downregulated in pancreatic cancer specimens compared wi

161 this receptor is shear stress dependent and downregulated in patients receiving TAVI.

162 1), FLG2, and loricrin (LOR) expression were downregulated in patients with ACD.

163 Finally, microRNA 218-5p, which is downregulated in patients with IPF, suppressed 15-PGDH e

164 d miRNA-150-5p expression were significantly downregulated in patients with peri-implantitis in compa

165 amma and Pref-1 expression was significantly downregulated in preadipocytes of both MFR males and fem

166 tory functions were enriched among the genes downregulated in response to stress.

167 ated with the AKT-mTOR signaling cascade are downregulated in SZ DLPFC.

168 gs, expression of SGMS1 in tumor tissues was downregulated in TCGA cohort only.

169 g a mitochondrial redox enzyme, was strongly downregulated in the absence of AMPK activity and that r

170 ich were predicted regulators of transcripts downregulated in the bone marrow and involved in lymphoi

171 hemistry and Western blotting, PPARalpha was downregulated in the corneas of humans with diabetes and

172 AIM2 was downregulated in the CP group compared with the H, G, an

173 TRIM20, TRIM16, and CARD18 were downregulated in the G, CP, and AgP groups compared with

174 of reactive astrogliosis, was significantly downregulated in the GFAP-ARO-KO hippocampus following G

175 ETV1 is downregulated in the LA during cardiac pressure overload

176 major regulator of cardiac functions and is downregulated in the majority of heart failure cases.

177 group of subjects we also show that GPR56 is downregulated in the PFC of individuals with depression

178 ssion of several cambial regulator genes was downregulated in the stems of the transgenic trees in co

179 m of pregnenolone synthesis was coordinately downregulated in these embryos, including the most downr

180 OTUD5 expression is markedly downregulated in tumor tissues.

181 e enriched for genes that were significantly downregulated in two prior case-control histological stu

182 tein kinase that modulates EGFR turnover, is downregulated in vemurafenib-resistant melanoma cells.

183 e focused on the genes that were uniquely up/downregulated in WT or HM at E16.5 vs. E14.5 to identify

184 Both IDL and ethyl linoleate/oleate downregulated inflammatory gene expression, but IDL more

185 er, upon viral control, CD4+ T cells quickly downregulated inhibitory receptors and differentiated in

186 in assembly, increases drug penetration, and downregulates ITGA5/FN1 expression, resulting in inhibit

187 ence that miR-19b targets syndecan-1 mRNA to downregulate its expression.

188 h Lmo2-induced T-ALL results from failure to downregulate Ldb1/Lmo2-nucleated transcription complexes

189 These tumors showed downregulated levels of the transcription factor prosper

190 n NK cells, the glucocorticoid dexamethasone downregulated LIMK expression, F-actin accumulation at t

191 ponses to fibrotic injury, including up- and downregulated long noncoding RNAs (lncRNAs) and transcri

192 e wild-type cells, the psr1 mutant failed to downregulate LST8 abundance and TORC1 activity when unde

193 ogy and emphasizes that KSHV is strategic in downregulating LXA4 secretion in the host to establish l

194 of Majors upregulates Minor-biased genes and downregulates Major-biased genes, engaging molecular pat

195 d type I collagen and interleukin-1beta, and downregulated matrix metalloproteinase-8, whereas period

196 Calcitriol downregulated MerTK mRNA and protein expression in both

197 biquitination contributes to its capacity to downregulate MET and inhibit human tumor cell proliferat

198 TDM downregulated MHC class II cell surface expression and i

199 restingly, acute or chronic cocaine exposure downregulated miR-124 levels concomitant with upregulati

200 , we have found that mycobacterial infection downregulated miR-148a-3p (now termed miR-148) in macrop

201 acy of simultaneously upregulating miR-7 and downregulating miR-21 and establishes a roadmap towards

202 caspase-mediated apoptosis by simultaneously downregulating miR-21 and upregulating miR-7 in differen

203 Profiling miRNAs reveals downregulated MIR181, and concomitantly upregulated MIR1

204 fication of miR-335 as the most consistently downregulated miRNA in AD.

205 ith an ERBB3-neutralizing antibody partially downregulated mTOR pathway activation but showed no effe

206 mice and humans, consumption of a fatty diet downregulates myeloid KLF2 levels.

207 impairing bacterial actin-based motility by downregulating N-WASP.

208 We show that miR-1010 downregulates nAcRbeta2.

209 pplied ripasudil prolonged graft survival by downregulating neovascularization and inflammation facto

210 an interferon gene signature in addition to downregulated neuritogenic and synaptic gene pathways wi

211 Moreover, downregulated neutrophil activation and increased levels

212 iferation (P <= 0.002) in CD8(+) T cells and downregulated NKG2D expression in NK cells (P = 0.001).

213 eased levels could represent a mechanism for downregulating Notch during UV-induced carcinogenesis.

214 mTORC1/2 inhibition downregulates NRG1-ERBB3, while upregulating pAkt T308 t

215 notable exception being a cluster of mostly downregulated oligodendrocyte-associated genes in the P7

216 te that alphaDR5-NPs loaded with agents that downregulate or inhibit FLIP are promising candidate age

217 late or activate the iPSC-enriched TFs while downregulate or silence the fibroblast-enriched TFs.

218 l12 In diabetic mice, pioglitazone treatment downregulated Osm, p66Shc, and Cxcl12 in the hematopoiet

219 aintained in 3D (P < 0.001), cadherin-11 was downregulated (P < 0.001) and HER2 increased (P < 0.05).

220 icantly altered (1 downregulated 4 up and 13 downregulated; p < 0.05) in MDD subjects.

221 analysis of transcriptomic data reveals that downregulated pathways in metastases are mainly immune-r

222 is recruited to the Pdcd1 locus by Blimp-1, downregulates PD-1 expression by facilitating the remova

223 are more potent than rapamycin, and robustly downregulate phosphorylated and insoluble tau, consequen

224 in mouse adipocytes and fly fat bodies with downregulated PI3K, which were confirmed by biochemical

225 generate AMP, unlike allosteric activators, downregulated pMLC but only when combined with 2DG and/o

226 Glucose withdrawal downregulated pMLC, and coupled with hypoxia, reduced pM

227 ets a specific population of LNs to globally downregulate PN odor responses in the AL.

228 Mutants in which UBP12 and UBP13 were downregulated produced smaller leaves that contained few

229 o enhance macrophage bacterial clearance and downregulate proinflammatory cytokine secretion.

230 ar adhesion protein 1 (AOC3/VAP1) as well as downregulated protective factors, in particular alkenal

231 eria, archaea, and eukaryotes PRF is used to downregulate protein production by inducing a premature

232 ebalance proteostasis in two ways: MLII mice downregulate protein translation and increase the integr

233 The majority of downregulated proteins in mutator mitochondria were subu

234 fibroblasts identified 24 upregulated and 20 downregulated proteins in the patients compared with 5 c

235 affects two anti-silencing factors: Epe1 is downregulated, reducing its chromatin association, and a

236 rythropoietin-regulated genes were generally downregulated relative to iron-replete mice, suggesting

237 caspase-3 and -PARP in colon cancer cells by downregulating RSK1 and MSK2 downstream targets, includi

238 ipids exhibits unfolded protein response and downregulates secretion.

239 A highly connected downregulated set of interneuron transcripts is present

240 Furthermore, early intervention downregulated several microglial receptor transcripts (e

241 signaling as another HCMV miRNA, miR-UL22A, downregulates SMAD3, which is required for maintenance o

242 TGFbeta stimulation downregulated SOX2 and induced epithelial-to-mesenchymal

243 afatinib treatment decreased CSC markers by downregulating SOX9 via FOXA2.

244 Within infected cells, EBOV downregulates STAT1 mRNA and interferon signaling, and i

245 l transcriptional response to starvation and downregulated subsets of TFEB targets.

246 s, a number of immune genes were found to be downregulated, suggesting an immune evasion strategy of

247 hil, NGAL protects from ANCA-induced NCGN by downregulating T(H)17 immunity.

248 the most common mechanism by which H. pylori downregulates T4SS function during murine infection, los

249 More specifically downregulating TaG7NPR1 homeologues or Ta7ANPR1 expressi

250 Genital cell remodeling by HIV includes downregulating TCR complex components and modulating che

251 with these findings, adenosine significantly downregulated TGFbeta signaling on fibroblasts, an effec

252 standing the mechanisms employed by HSV-1 to downregulate the anti-viral type I interferon (IFN) medi

253 origenic epithelial cells), we show that IFs downregulate the cell-cell adhesion molecule E-cadherin

254 oenzymes (proteases, lipases, nucleases) and downregulate the expression of surface binding proteins.

255 level at the late stage of the experiment to downregulate the osteoclast number by inhibiting Th1 and

256 nduced small intestinal IL-10 expression and downregulated the claudin-2 expression.

257 by knockdown of ATG5 Additionally, trehalose downregulated the expression of C-C motif chemokine rece

258 Moreover, PMA downregulated the expression of collagen-encoding genes

259 Conversely, HCMV downregulated the expression of nasal epithelial cell-re

260 seudomonas syringae in wild-type (WT) plants downregulated the expression of several morning core clo

261 In particular, the MCPyV early gene downregulated the expression of the tumor suppressor gen

262 IDL also downregulated the expression of unhealthy skin signature

263 d activator of transcription 3 and IL13, and downregulated the genes in cell-cycle progression, which

264 MAPK p38 signaling cascades while partially downregulated the pro-survival PI3K-AKT cascade, thereby

265 31 and SKBR3 breast cancer cells grown in 3D downregulated the proliferative marker Ki67 (P < 0.05) a

266 In the first mechanism, Dab2 intracellularly downregulates the integrin alpha(IIb)beta(3) receptor, c

267 Mac1p downregulates the major Cu consumer SOD1 to spare Cu for

268 tiation regulatory receptor tyrosine kinase, downregulates the telomerase RNA component TERC, confers

269 trate that latently expressed HCMV miR-US5-2 downregulates the transcriptional repressor NGFI-A bindi

270 tly stimulating tumor cell proliferation and downregulating the expression of apoptotic proteins.

271 mportant, NC1-peptide exerted its effects by downregulating the expression of microtubule (MT) plus-e

272 transcription by the cytokine, we found that downregulating the expression of signal transducer and a

273 mRNAs transcribed from cccDNA, we found that downregulating the expression of STAT1, SMCHD1, or PML s

274 ted PD pathologies and motor impairments via downregulating the expression of these key factors.

275 We show that, by downregulating the metabolism of lipids through the key

276 n-activated protein kinase (MAPK) pathway by downregulating the phosphorylation of MEK and extracellu

277 drive the production of a new protein while downregulating the production of another protein, thus m

278 PD-1 limits the viability of ILC2s and downregulates their effector functions.

279 rtezomib and carfilzomib, do not effectively downregulate these proinflammatory cytokines.

280 ceptor to the RNA-induced silencing complex; downregulated these genes in the lung endothelium; and r

281 ostasis, while the F4/80(-) MHCII(HI) subset downregulated these putative signaling axes.

282 tify a therapeutic role for tau reduction in downregulating this pathway and ameliorating ASD-like sy

283 feedback via activation of protein C, which downregulates thrombin generation by enzymatically inact

284 Here, we show that HIV-1 Vpu downregulates Tim-3 from the surface of infected primary

285 Here, we demonstrate that HIV-1 Vpu downregulates Tim-3 from the surface of infected primary

286 In vitro, TGFbeta1-mim downregulated TNF-alpha production, IL-8 gene expression

287 mouse model of early parkinsonism, GATs are downregulated, tonic GABAergic inhibition of DA release

288 ization-Promoting Protein 1 (TPPP1) mRNA and downregulates TPPP1, thereby promoting the invasion and

289 Downregulated transcripts in our model showed a signific

290 d towards oxidative phosphorylation in EP300 downregulated tumors.

291 n expressions of the type I IFN pathway were downregulated under hypoxic conditions.

292 tate and their expression remains high or is downregulated upon activation, whereas 'negative feedbac

293 that localizes to the vacuolar membrane and downregulates vacuolar membrane fusion.

294 cted by upregulated transcripts, while those downregulated were critical for cell growth and division

295 genes coding for transcription factors were downregulated, whereas all genes coding for members of t

296 pts associated with N-glycan processing were downregulated while those associated with lipid cataboli

297 ism, coagulation, and adaptive immunity were downregulated, while inflammation-related genes were upr

298 tep aerobics, altered urinary metabolism and downregulated WISP1.

299 Furthermore, overexpression of miR-466o-3p downregulated WT1 protein and promoted podocyte injury i

300 suppressed endothelial cell proliferation by downregulating YAP1 signaling.