ライフサイエンスコーパス: downregulation

1 more effective than antibody-mediated IGF1R downregulation.

2 nd life-span extending effect of IIS pathway downregulation.

3 pregulation, Hindsight upregulation, and Cut downregulation.

4 egulated concomitant with keratin 10 (KRT10) downregulation.

5 I-HDAC4 signaling and L-type calcium current downregulation.

6 products of APA, leading to their systematic downregulation.

7 ant melanoma resistant to ACT due to antigen downregulation.

8 membrane domain of Vpu is required for Tim-3 downregulation.

9 investigated as a potential mediator of pMLC downregulation.

10 lation between DNA hypermethylation and mRNA downregulation.

11 n both Nef and AP2 to enable CD4 binding and downregulation.

12 que transcriptomic profiles and global miRNA downregulation.

13 ctional connectomics involved in hippocampal downregulation.

14 dies to stimulate receptors and induce their downregulation.

15 these tyrosines are targets for NO-dependent downregulation.

16 n of cancer cells nor did it induce receptor downregulation.

17 knock-in mice, which are deficient in IFNAR1 downregulation.

18 thways while escaping beta-arrestin-mediated downregulation.

19 e-brain connectomics, during hippocampal CA1 downregulation.

20 clones exhibited the lowest CD4 and tetherin downregulation activities, while subtype D and B clones

21 ake by SKOV3/Luc cells in vitro due to uMUC1 downregulation after docetaxel therapy was paralleled by

22 onical translation pathways show significant downregulation after m6A loss.

23 eron-stimulated gene signature, HLA class II downregulation and a developing neutrophil population th

24 ncer therapeutic targets to disconnect IGF1R downregulation and beta-arr-BS.

25 lino knockdown in zebrafish, results in Sox2 downregulation and causes the developmental defects anop

26 icroRNAs mediates hyperglycemia-induced JunD downregulation and myocardial dysfunction in experimenta

27 h renal injury, paricalcitol prevented TRAF3 downregulation and NF-kappaB2-dependent gene upregulatio

28 high TSH doses, we studied the roles of TSHR downregulation and of G(i)/G(o) proteins.

29 neddylation of cullin 3 was linked to AGER1 downregulation and that induction of NRF2 using an adeno

30 ive function of Parkin and identified Parkin downregulation as a critical mechanism underlying PHGDH

31 It also indicated the role of WISP1 downregulation as a potential mechanism of loading-drive

32 ows a previously undocumented role for PRDM8 downregulation as a potential transcriptional regulation

33 downregulated in human and rat HCCs, and its downregulation associated with TP53 mutations.

34 pithelial cells, we demonstrated that N-WASP downregulation attenuated P aeruginosa-induced actin str

35 HLA-II downregulation by class II transactivator knockout did n

36 GLUL downregulation by shRNA caused a 40% increase in the met

37 Rad51 downregulation by the combination of cisplatin and Nutli

38 Interestingly, the IL-6 downregulation by VR23 was significantly more pronounced

39 riple-negative breast cancer (TNBC), miR-127 downregulation correlates with decreased disease-free an

40 rroptosis inhibitors blocked death from NRF2 downregulation, demonstrating a critical role of NRF2 in

41 d the resistant cells to paclitaxel, and its downregulation desensitized the parental cells.

42 rsion, but the molecular mechanism for IFNAR downregulation during IAV infection remains unclear.

43 As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type

44 tem bias" targeting of the IGF1R to uncouple downregulation from signaling.

45 Overall, the median CD4 downregulation function of natural Vpu isolates was simi

46 }, 0.86 to 1.18]), while the median tetherin downregulation function was moderately lower than that o

47 These data suggest that miR-149 downregulation functionally contributes to breast tumor

48 Furthermore, PfHsp70-1 downregulation hypersensitizes parasites to heat shock a

49 Mechanistically, MEK5 downregulation impairs phosphorylation of the catalytic

50 e RLIM E3 ligase activity, showed consistent downregulation in cells from the affected males.

51 e responses from focal subjects and caused a downregulation in genes associated with immune system re

52 hat the change in Her6 dynamics precedes the downregulation in Her6 levels.

53 41 genes differentially spliced after NOVA2 downregulation in human neural cells.

54 recognized as a possible mechanism for Tie2 downregulation in sepsis.

55 SST downregulation in specific cortical and striatal subregi

56 ncing from post-mortem AD human brains shows downregulation in the expression of mitochondrial influx

57 re, chronic alcohol consumption caused NBCn1 downregulation in the hippocampus and striatum of mice a

58 -stroma interactions by showing that miR-149 downregulation in TNBC enhances reciprocal growth factor

59 epressed cellular contractility) and SERCA2a downregulation in ventricular cardiomyocytes from C-dnO1

60 effect on neurite outgrowth induced by NOVA2 downregulation in vitro and to rescue alterations of ret

61 DRAIC downregulation increased cell invasion and soft agar col

62 In particular, NREP downregulation increases the protein abundance of 3-hydr

63 FMRP downregulation induced by CRISPR/Cas9 and shRNA techniqu

64 DCLK1 downregulation inhibited 48-kDa beta-catenin expression.

65 Our results suggest that NEIL2 downregulation is a plausible mechanism by which H. pylo

66 The loss-of-eye phenotype of M1BP downregulation is dependent on Wg upregulation as downre

67 2 knockdown had no effect, we concluded that downregulation is not involved in the biphasic cAMP resp

68 ly expressed in various types of cancer, its downregulation leads to reduced cell proliferation.

69 In contrast, GhTCP4 downregulation led to slightly longer fibers and thinner

70 proach in hepatocytes in vivo reversed AGER1 downregulation, lowered the level of AGEs, and improved

71 CD2 downregulation may attenuate antitumor T cell responses,

72 This include the downregulation of 25 proteins in PI3K-Akt signaling path

73 f a cluster featuring Hsp90ab1 and Hsp70 and downregulation of a cluster of mitochondrial protein com

74 E2 as the receptor for entry with subsequent downregulation of ACE2, corneal inflammation in Ace2(-/-

75 The transcriptional profile showed downregulation of adaptive immunity and induction of pro

76 on, and lipid profile and to explore whether downregulation of adipocytokines and markers of systemic

77 accumulation after RNA interference-mediated downregulation of ALAS2 in human erythroid cellular mode

78 Downregulation of all the TaNPR1 homologues via virus-in

79 monary grafts and are critical for the local downregulation of alloimmune responses.

80 spholipids and biosynthesis of glycerolipid, downregulation of ammonium transport and nitrate assimil

81 a accompanied by protein thiol oxidation and downregulation of antioxidant gene expression, cofilin a

82 The downregulation of antiviral activity in the presence of

83 proteins Bcl-2, HSP-70, LIVIN, and PON2 with downregulation of apoptosis inducing mitochondrial assoc

84 In chick retinal ganglion cells (RGCs), downregulation of Arl8B reduces axon branch density and

85 Furthermore, up or downregulation of AtSnRK1 positively affected KFB(PAL) (

86 Upregulation or downregulation of autophagy in vitro promotes or inhibit

87 We found significant downregulation of autophagy-related genes particularly,

88 rom StMSI1-OE and StBMI1-1-AS lines revealed downregulation of auxin and brassinosteroid genes, and u

89 action may occur through desensitization or downregulation of beta-cell GIP receptors (GIP-R).

90 Downregulation of blastocyst WNT signals drives the tran

91 and beta-catenin, upregulation of Snail, and downregulation of BMP7 and Klotho.

92 RISPR/Cas9 knockout of this enhancer induces downregulation of both genes.

93 egulation is dependent on Wg upregulation as downregulation of both M1BP and wg, by using wg(RNAi), s

94 sed cell proliferation whereas the transient downregulation of BRF1 reduced proliferation and mediate

95 Downregulation of BST-2/tetherin and CD4 by HIV-1 viral

96 y macrophages and CD4(+) T cells through the downregulation of C-C motif chemokine receptor 5 (CCR5)

97 flammatory mediators' production through the downregulation of C/EBP but not NF-kappaB activation, le

98 Transcriptome analysis of SCA7 mice revealed downregulation of calcium flux genes accompanied by abno

99 e such mechanism, and depends in part on the downregulation of calcium-dependent SK-type K(+) channel

100 rmed a behavioral genetic screen through the downregulation of candidate ion channels in the lateral

101 In fact, downregulation of CAV1 expression resulted in the activa

102 ibiting the trafficking of MDSCs through the downregulation of CCR2 and CXCR2, and by promoting MDSC

103 mechanisms: (i) decreased entry through the downregulation of CCR5 in T cells and decreased CD4 expr

104 nisms of suboptimal efficacy of DARA include downregulation of CD38 expression and overexpression of

105 nistically, in the absence of Tet2 and Tet3, downregulation of CD86, which normally occurs following

106 MYC-high HSPCs showed significant downregulation of cell adhesion genes, consistent with e

107 g with chromatin remodeling complex PRC2 and downregulation of cell migration-regulating genes.

108 ubiquitin ligase-mediated ubiquitination and downregulation of cell surface CD98.

109 ling of cells expressing either miRNA showed downregulation of cell-cycle progression and mitosis-ass

110 Similar to ALS patients, a compensatory downregulation of cholesterol synthesis occurred in the

111 Confocal microscopic images showed downregulation of CLDN-1, FLG-1, and FLG-2 expression.

112 nt1-Cre mutant embryos, which, together with downregulation of Col2a1 and Wnt signaling target genes,

113 K6 silencing in human SMCs in vitro leads to downregulation of contractile markers and increase in MM

114 cells displayed progressive differentiation, downregulation of costimulatory molecules, and elevated

115 al phenotype, all A-T participants exhibited downregulation of critical genes involved in B cell func

116 a pro-oncogenic potential of SETDB1 via the downregulation of critical tumor-suppressive genes.

117 Consistently, ZSCAN4 depletion leads to downregulation of CSC markers, decreased ability to form

118 CT26 and 4 T1 tumor -bearing mice led to the downregulation of CTLA-4 on tumor -infiltrating T cells,

119 lly, br-met-associated CNS-myeloid exhibited downregulation of Cx3cr1.

120 a cells showed higher proliferation rate and downregulation of Cxcl12 and Cxcr4.

121 The cellular mechanism was identified as downregulation of cyclin-dependent kinase inhibitor 1B (

122 molecule (LFA-1) expression by T cells, and downregulation of cytotoxic T cell lytic potential.

123 kers, sometimes together with DNA damage and downregulation of DNA repair and antioxidant enzymes.

124 ernative model of scaling driven by feedback downregulation of Dpp receptors and co-receptors.

125 mors induce rho in tumor cells by autonomous downregulation of E-cadherin (E-cad) and consequent acti

126 Deregulation of adherens junctions by downregulation of E-cadherin and p120-catenin resulted i

127 d surface biotinylation data show reciprocal downregulation of each other's surface density.

128 ERGIC tether p115, GLUT4, and sortilin, and downregulation of either p115 or CHC22, but not GM130 or

129 Multiomic analysis revealed downregulation of electron transport chain (ETC) compone

130 Transcriptomics analysis revealed downregulation of endoplasmic reticulum-associated prote

131 Whole-body and neuronal-specific downregulation of enzymes in the tyrosine degradation pa

132 Downregulation of EP300 gene expression was associated w

133 diac pressure overload produced a consistent downregulation of ErbB4, Etv1, Scn5a, and Gja5 and upreg

134 ed HSC content in the murine bone marrow and downregulation of expression of MEIS target genes.

135 apoptotic defects in mouse ocular tissue and downregulation of eye development markers Lhx2, Pax6, Ja

136 re, high-fat diet (HFD)-fed mice exhibit the downregulation of FABP5 and ST2 expression in the lung t

137 l lines, nuclear accumulation of MDM2 caused downregulation of FBXW7 and consequent upregulation of p

138 alized within the 3'UTR of FERMT2, induced a downregulation of FERMT2 expression through binding of m

139 Concordant with reduced S-lignin was downregulation of ferulate 5-hydroxylases (F5Hs).

140 upregulation of FLG-1 in response to PPD but downregulation of FLG-2.

141 We found that downregulation of Fyn in dMSNs, but not in iMSNs, reduce

142 (iPSC)-derived neuron culture media, and the downregulation of gene expression of TSPAN5, DDC, MAOA,

143 Significant downregulation of gene expression profiles consistent wi

144 d 5-hydroxymethylcytosine levels in the DNA, downregulation of gene signatures associated with ovaria

145 RNA deep sequencing showed significant downregulation of genes associated with breast cancer pr

146 role in innate immunity and inflammation and downregulation of genes associated with cell cycle and a

147 treated with liposomal A2AR agonist revealed downregulation of genes associated with matrix degradati

148 hared between the two hosts, we observed the downregulation of genes associated with stress chaperone

149 ith exogenous IL-33 results in a generalized downregulation of genes critical to T cell biology toget

150 Moreover, we observed downregulation of genes encoding H2A-ubiquitin ligase an

151 and cell cycle-related processes, as well as downregulation of genes encoding oxidoreductases and nut

152 renal glands exhibited significant and early downregulation of genes involved in metabolism, coagulat

153 in mRNAs from polysomes to monosomes and the downregulation of genes involved in translation and ribo

154 Notch signalling, TGFbeta/BMP antagonists, a downregulation of genes related to glycolysis and the TC

155 and immune cell trafficking, in addition to downregulation of genes supporting cellular assembly and

156 from loss of EPT1 or PSD1 and PSD2 leads to downregulation of genes that impact mitochondrial functi

157 Furthermore, VitC-treated bacteria showed downregulation of genes underpinning biofilm signaling (

158 including the classical Warburg effect, the downregulation of gluconeogenesis and amino acid metabol

159 cells from stiff to soft substrates causes a downregulation of glycolysis via proteasomal degradation

160 indicate that physiological fasting-induced downregulation of GRK2 in the liver is key for allowing

161 Such downregulation of GRK2 levels is liver-specific and can

162 ous miR-370-3p inhibits HCN4 mRNA and causes downregulation of HCN4 protein, downregulation of I(f),

163 Conversely, preventing full downregulation of hepatic GRK2 during fasting using aden

164 A and causes downregulation of HCN4 protein, downregulation of I(f), and bradycardia in the isolated

165 Sensitivity was associated with strong downregulation of IFN-gamma and IFN-alpha gene signature

166 In vivo, PX treatment caused substantial downregulation of IGF1R, suppressing the growth of Ewing

167 In triple transgenic mice, downregulation of IKK2 (Sftpc-cRaf-IKK2DN) in cRaf-induc

168 -35-producing B cells might take part in the downregulation of immune response in mycobacterial infec

169 Active periodontal disease may result in downregulation of inflammasome regulators that may incre

170 rasound (cortex P = .019, medulla P = .001), downregulation of interleukin (IL)-1beta (P = .050), and

171 essed AKT gene signature and transcriptional downregulation of IRS2.

172 protein, resulting in reduced Zbtb11 dosage, downregulation of its target genes, and impaired complex

173 A biosynthesis and OPDA-responsive genes but downregulation of JA biosynthesis and JA response genes.

174 , which were associated with transcriptional downregulation of key DNA-repair genes, and may revive p

175 ng patient-derived xenograft models, through downregulation of key genes involved in leukemogenesis.

176 nd type I interferon signaling pathways, but downregulation of key host factors known to support ZIKV

177 l and repairing ability, as evidenced by the downregulation of key pathways regulating myeloid cell c

178 -SGC coupling, increased sensitivity to ATP, downregulation of Kir4.1 potassium channels and increase

179 ) by imazapyr showed concentration-dependent downregulation of known and most acylsugar candidate gen

180 nanomolar concentrations promote a dramatic downregulation of KRAS and NRAS expression, but only if

181 Here, we show that the age-dependent downregulation of lamin B1, one of the nuclear lamins in

182 increased risk of coronary artery disease by downregulation of LDLR levels.

183 FN-I production was marked early on by their downregulation of leukemia inhibitory factor receptor an

184 Downregulation of LncRNA MALAT1 by its siRNA prevented g

185 ced behavioral aberrations, blocked cortical downregulation of local GSK-3 (glycogen synthase kinase

186 operly, but then show biased transcriptional downregulation of long genes, signs of DNA damage, neuro

187 Furthermore, downregulation of LRP1 in an in vivo mouse model of tau

188 with a retinal self-antigen caused selective downregulation of LXA(4) in lymph nodes draining the sit

189 found that upregulation of wg as a result of downregulation of M1BP also induces apoptotic cell death

190 Downregulation of M1BP function suppresses eye fate resu

191 Downregulation of M1BP results in more than two-fold ind

192 acterized by decreased CD4 T-cell counts and downregulation of major histocompatibility complex class

193 ient for recognition by T cells owing to the downregulation of major histocompatibility complex I sur

194 h autophagosomes and lysosomes, mediates the downregulation of mammalian SIRT1 protein during senesce

195 Microarray analysis revealed downregulation of matrisome, cell cycle and immune relat

196 These data suggest that downregulation of mesothelial cell-derived ITLN1 in the

197 C-I are rarely found(5) despite the frequent downregulation of MHC-I expression(6-8).

198 companied by key miRNA alterations including downregulation of miR-106a~363 cluster and upregulation

199 nfirms the role of the EsxBA proteins in the downregulation of miR-147.

200 This was accompanied by downregulation of miR-210 targets ISCU (iron-sulfur asse

201 Indeed, downregulation of miR-218 in the mPFC in adolescence pro

202 We find that downregulation of miR-218 in the mPFC increases suscepti

203 rtantly, we demonstrated that shRNA-mediated downregulation of Mitf expression or inhibition of p38 s

204 Gene set enrichment analysis showed downregulation of multiple WNT-related genes in primary

205 associated with MYC upregulation and marked downregulation of MYC's negative regulator miR-34a, a p5

206 These results demonstrate that the downregulation of N/OFQ levels in the CeA may be respons

207 The H. pylori infection-induced downregulation of NEIL2 was specific, as Campylobacter j

208 Ketamine specifically induces downregulation of neuregulin-1 (NRG1) expression in parv

209 in both humans and rodents induces a robust downregulation of neuroligin-2, a key component of the i

210 arget genes are activated before significant downregulation of nuclear localization of Cic and demons

211 omib in reversing the ubiquitination-induced downregulation of OAT1 expression and transport activity

212 sion of GLS2 in T98G glioma cells, including downregulation of oncogene c-Myc.

213 ed 27 from the benchmark BETi, JQ-1, showing downregulation of oncogenes and upregulation of tumor su

214 to inflammation and allograft rejection but downregulation of oxidative phosphorylation and fatty ac

215 CD4SP T cells from TCF1 KO mice exhibit downregulation of P2 transcript variant expression as we

216 n(+) mature oligodendrocytes with reciprocal downregulation of paired related homeobox protein 1.

217 hanistically, ACC2 iKO prevented HFD-induced downregulation of parkin.

218 romoted cellular invasion of MFS through the downregulation of PCDH9 in the adjacent normal fibroblas

219 for the MYC oncogene pathway correlated with downregulation of pertinent genes.

220 revention of photoinhibition and a momentary downregulation of photosynthetic quantum yield.

221 g plasminogen receptor annexin 2A as well as downregulation of plasminogen activator inhibitor serpin

222 transcribed from the Hox complexes, and the downregulation of pluripotency associated microRNAs.

223 Moreover, downregulation of POLQ by ZEB1 fostered micronuclei form

224 h alterations in pyrimidine biosynthesis and downregulation of polycomb repressive complex 2 targets.

225 genomic compartments during ZGA, and causes downregulation of post-zygotically expressed genes.

226 mune cell modulation was associated with the downregulation of pro-inflammatory genes and the upregul

227 OS1 and NOS3) and neuroprotective genes with downregulation of proinflammatory genes in Group 1 in co

228 s mTORC1 signaling, leading to a significant downregulation of protein synthesis.

229 These observations were in line with downregulation of PTEN and increase in beta cell prolife

230 in mice, which is associated with extensive downregulation of PUFA-ePLs.

231 pid and sustained cortical disinhibition via downregulation of PV-specific NRG1 signaling.

232 he LA from Etv1(f/f)Mlc2a(Cre/+) mice showed downregulation of rapid conduction genes and upregulatio

233 rate for the first time a miR-106b dependent downregulation of RBMS1 in prostate carcinoma.

234 In vivo downregulation of renal GRK4 expression, via ultrasound-

235 ting developmental processes and progressive downregulation of repeat-associated siRNAs following gen

236 (R) formulation was followed by a successful downregulation of reporter protein expression.

237 Expression of LANA leads to downregulation of RLIM protein levels.

238 Genetic downregulation of Rubicon inhibited autosis and reduced

239 These data suggest that the downregulation of RUNX1 in conjunction with anti-VEGF ag

240 ent manner in del(5q) cells, and mutation or downregulation of RUNX1 rendered cells resistant to LEN.

241 Targeted downregulation of select endogenous plant genes is known

242 the transsulfuration pathway, the subsequent downregulation of serine biosynthesis and the adaptation

243 Downregulation of SERPINB1, a protein elevated in brain

244 RNA sequencing reveals downregulation of several postreceptor signaling protein

245 Furthermore, the downregulation of several TAGs in T2D (including CLDN10,

246 e, we show that in a mouse model of CIA, the downregulation of Shh signaling in the hair matrix is a

247 patic autophagy impairment was attributed to downregulation of SIRT1 signaling and mTOR was not impli

248 utophagy impairment in GSD-Ia is mediated by downregulation of SIRT1/FoxO3a/AMPK/PPAR-alpha signaling

249 Downregulation of Skp2 or treatment with the Skp2-specif

250 nalysis revealed that mouse tumors exhibited downregulation of Star and Cyp11b1 and upregulation of E

251 nectar production, which was correlated with downregulation of STYLISH homologs that have previously

252 nalyses of tumor-derived cell lines revealed downregulation of TGFbeta signaling and upregulation of

253 roducing B cells and was associated with the downregulation of Th1/Th17 and upregulation of Foxp3(+)T

254 weakening of the gap junctions results from downregulation of the abundance of a gap junction molecu

255 that high IL8 expression is associated with downregulation of the antigen-presentation machinery.

256 t cell intrinsic, revealing a cell-extrinsic downregulation of the antiviral NK cell response by adre

257 n FBN-ARO-KO mice was associated with robust downregulation of the astrocyte-derived neurotrophic fac

258 This increase of SQOR induces the downregulation of the cystathionine beta-synthase and cy

259 Transcriptomic analyses reveal downregulation of the ECM gene fibulin-5, which when ove

260 tion of FGF signaling was accompanied by the downregulation of the FGF target genes tbxt/brachyury an

261 Gene expression analysis revealed a 4-fold downregulation of the gene NMNAT1, residing indeed in th

262 Meanwhile, ATP-grown S. costatum exhibited downregulation of the genes related to a series of metab

263 of HSV-1 immune evasion via ICP22-dependent downregulation of the host T cell costimulatory molecule

264 ma tumors, efficient stromagenesis relies on downregulation of the IFNAR1 chain of the type I interfe

265 of the inflammatory cytokine IL-6; and (iii) downregulation of the JAK1, STAT1, NF-kappaB, and ERK1/2

266 In melanoma, downregulation of the lineage addiction oncogene microph

267 nculin-linked molecular force as well as the downregulation of the Lrp5-CSF1-CD105 regulatory axis.

268 ed specific changes in gene expression, with downregulation of the MEIS1 transcription factor and its

269 Developmental downregulation of the splicing regulator PTBP1 in immatu

270 hile Hfq is required for RNA sponge-mediated downregulation of the sRNA, ProQ can inhibit this regula

271 Hey2 in the NOTCH signaling pathway, causing downregulation of the transcription factor Sox17.

272 h reduced astrocyte/microglia activation and downregulation of the transcriptional regulators CEBPD a

273 echanism of immunosuppression by hypoxia via downregulation of the type I IFN pathway and its autocri

274 ts indicate that hypoxia leads to an overall downregulation of the type I IFN pathway due to represse

275 colonization in animal models often leads to downregulation of the type IV secretion system (T4SS), t

276 The downregulation of this cytokinin regulator in the Yh hap

277 gocytosis was examined to be associated with downregulation of Toll-like receptor 4 (TLR4) expression

278 ne expression studies revealed a significant downregulation of TOP II and Ku70, crucial enzymes for D

279 ts in a sharp decrease in LST8 abundance and downregulation of TORC1 activity.

280 Downregulation of TRIB3 was mediated by LRRFIP1 independ

281 Perineural application of RTX caused downregulation of TRPV1, CGRP, and IB4 binding and upreg

282 Downregulation of TSPAN5 expression by ethanol or acampr

283 mates, and have heightened phosphaturia from downregulation of two key NaPi cotransporters in the kid

284 expression of ILC1/NK cell-related genes and downregulation of type 3 signature genes.

285 PE) changes including structural disruption, downregulation of visual cycle genes, and altered angiog

286 Chemogenetic downregulation of VTA-mPFC DA neurons' firing activity a

287 Finally, we show that downregulation of Wnt signaling and Chk1 expression lead

288 ifically, DAB2IP inhibited WNT signaling via downregulation of WNT5B, an important stemness inducer.

289 Here we show that the transient downregulation of YAP in mouse ESCs perturbs cellular ho

290 In contrast, overexpression, but not downregulation, of alpha2delta3 enhances neuronal firing

291 shown that NC1-peptide induced considerable downregulation on a number of cell polarity and planar c

292 ChemR23 downregulation reversed these effects.

293 JunD downregulation was associated with oxidative stress and

294 This downregulation was related to both decreased Klotho tran

295 bjects, our main findings during hippocampal downregulation were: (i) in the absence of abnormal biom

296 However, because inhibiting TSHR downregulation with combined expression of a dominant ne

297 ays showed upregulation with incubation, but downregulation with EE, suggesting that EE may prevent o

298 tion of lipid catabolism with high food, and downregulation with low food.

299 ilencing with dose- and time-dependent IGF1R downregulation without associated beta-arr-BS.

300 Successful IGF1R targeting requires receptor downregulation, yet therapy-mediated removal from the ce