ライフサイエンスコーパス: dramatic effect

1 bation with CaCl(2) had a significantly more dramatic effect.

2 r absence of even a single photon can have a dramatic effect.

3 Substitution L493A had a less dramatic effect.

4 related cytokinin, showed a similar but less dramatic effect.

5 ng and previously thought negligible, have a dramatic effect.

6 ssociated with a severe phenotype had a more dramatic effect.

7 hydrophobic core position d that causes this dramatic effect.

8 o Cys (W176C) and Gly-183 to Ala (G183A) had dramatic effects.

9 eas mutations of the other residues had less dramatic effects.

10 lts define a particular change with the most dramatic effects.

11 This has two dramatic effects: 1) it prevents oligomerization of the

12 n the Arg-187-Tyr-223 couple have a far less dramatic effect (3-20-fold reductions).

13 Three pairs of mutations exerted dramatic effects, ablating channel function or either re

14 s, which are retained within tissue and have dramatic effects, and hydrophilic drugs, which are rapid

15 The most dramatic effects are observed for the addition of excess

16 Dramatic effects are observed, including a stabilization

17 Similar, but less dramatic, effects are demonstrable with ATP and its nonh

18 erpyridine-based catalysis and that the most dramatic effects arise from steric and solubility factor

19 een recently tested in the clinic and showed dramatic effects at the level of responding NK and CD8(+

20 e termination codon (PTC) mutations can have dramatic effects--both adaptive and deleterious--on gene

21 This dramatic effect by a nonenzymatic protein of 6 kDa is no

22 These dramatic effects can be described as cooperative adsorpt

23 These properties underscore the dramatic effects caused by the increased number of catio

24 Also, cell orientation had a dramatic effect; cells cultured as epithelia exhibited m

25 he spin-vortex-mediated stimulus creates two dramatic effects: compromised integrity of the cellular

26 enzymes but with nicotinamide having a more dramatic effect during smaller fluctuations in concentra

27 t ELF EMF exposure has the capacity to cause dramatic effects from behaviour to physiology and protei

28 pe E light chain with at least two producing dramatic effects: Glu335Gln causes the toxin to transfor

29 ed over a range of temperatures, showing the dramatic effect hydrogen bonding perturbation on polar s

30 is common understanding, disorder can have a dramatic effect in a one-dimensional disordered optical

31 hanges in conformational dynamics can have a dramatic effect in determining whether a protein is amyl

32 Complement inhibition with eculizumab has a dramatic effect in PNH and has a major impact in the pre

33 dogenous immunoglobulin locus, with the most dramatic effect in the V to DJ(H) rearrangement.

34 fect in in vitro assays, opsonizing Ab had a dramatic effect in vivo on Y. pestis-neutrophil interact

35 Eliminating STAT5 expression had dramatic effects in both contexts, and this new work and

36 Dramatic effects in catalysis are also enabled by PAd3 d

37 The HOXA9 homeoprotein exerts dramatic effects in hematopoiesis.

38 se removal from yeast causes one of the most dramatic effects in terms of rapidity and scale.

39 letion of endogenous BRAG2 by siRNA leads to dramatic effects in the cell periphery; one such effect

40 Env levels in virions, E767stop had the most dramatic effect, increasing the Env content per virion 2

41 rcomeric proteins are abnormal, but the most dramatic effect is in the localization of F-actin, with

42 limitations in study designs, however, these dramatic effects might have been misinterpreted and ther

43 le resemblance with the carbon atom having a dramatic effect not only on the reactivity, but also on

44 The dramatic effects observed for the "blue dimer" make it a

45 fic subunit being constrained, with the most dramatic effects occurring when the constraint was betwe

46 Instead, our in vitro studies identify a dramatic effect of B7-2 engagement on IgG, but not IgM s

47 The most dramatic effect of BBG was to slow recovery from inactiv

48 are lost over six generations, indicating a dramatic effect of breeding patterns on genetic diversit

49 mellar vesicles) and accurately quantify the dramatic effect of cholesterol on the GalCer domain surf

50 The dramatic effect of F was independent of its cleavage sit

51 We have pursued this dramatic effect of genetic background by performing a ge

52 We observe a dramatic effect of halide identity on relative intensiti

53 The dramatic effect of IPs on the transcriptional landscape

54 This seemingly dramatic effect of mutating a nonpolar residue for a sma

55 methine cyanine scaffold and demonstrate the dramatic effect of restraint on the temperature sensitiv

56 ilibrium rHDL products; however, there was a dramatic effect of sterol concentration on rHDL particle

57 The dramatic effect of the carbinol configuration on cytotox

58 The dramatic effect of the D299G.T399I haplotype on expressi

59 The most dramatic effect of the mutation was on the electron tran

60 ears ago, Studer and co-workers reported the dramatic effect of the reaction of re-formation of alkox

61 In contrast to the dramatic effect of the T101A mutation on Na(+) binding,

62 These results highlight the dramatic effect of the TNP moieties on CheA-nucleotide i

63 The dramatic effect of this reagent by in situ generation of

64 taining enzymes for cellular energy, and the dramatic effects of altering protein conformations on ne

65 articular copy number variations (CNVs) have dramatic effects of disease and traits.

66 Despite the dramatic effects of dopamine in inhibiting the formation

67 The dramatic effects of Kv4.2 deletion on KChIP expression s

68 In line with these dramatic effects of L1 on tumor vasculature, the ectopic

69 screte subtypes of neurons we uncovered more dramatic effects of MeCP2 on gene expression, overcoming

70 t polytropic viruses, we demonstrate several dramatic effects of mixed infections.

71 that this phenomenon may explain some of the dramatic effects of proteasome inhibitors observed in ot

72 The dramatic effects of the anti-IgE mAb omalizumab to lower

73 2.8 and 66.2 kcal/mol, the latter indicating dramatic effects of the choice of bridge structure on S-

74 ty in the active-site loops may underlie the dramatic effects of the G63P mutation on the activity pr

75 ence quenching experiments show that despite dramatic effects of the lipid phase transition on PLA2 a

76 nents of mixed retrovirus infections and the dramatic effects of these interactions on disease proces

77 The dramatic effects of these lipid signals are detected ele

78 sheep or neonatal rat, mouse, or pig reveal dramatic effects of urinary tract obstruction on renal g

79 One of the most dramatic effects of Vpr is the induction of cell cycle a

80 Animal handling has a dramatic effect on (18)F-FDG biodistribution and signifi

81 t affect gamma-secretase activity, but has a dramatic effect on Abeta levels in vivo.

82 However, the 5HTTLPR polymorphism had a dramatic effect on adverse events.

83 In cultured cells, human IFN-beta-1a had a dramatic effect on barrier properties, increasing electr

84 t the lipid environment of cholesterol has a dramatic effect on binding and activity.

85 Reducing ERalpha in the VTA had a more dramatic effect on binge-like drinking than reducing ERb

86 ious findings that estrogen deficiency has a dramatic effect on bone homeostasis in men.

87 nes, pairwise deletion of hs3b and hs4 had a dramatic effect on both class switch recombination and I

88 Elevated N2 pressures (>1 atm) have a dramatic effect on catalysis, increasing N2 solubility a

89 covery that the electrical stimulus can have dramatic effect on cell behavior.

90 rotubule-binding domain of p150(glued) has a dramatic effect on cell division, resulting in the gener

91 ity using specific inhibitors revealed quite dramatic effect on condensation of chromatin and chromos

92 Thus, antigen structure has a dramatic effect on DC-SIGN-mediated uptake and trafficki

93 of fat-tailed step-size distributions have a dramatic effect on dispersion of organisms, where such t

94 of cytokinin levels in transgenic plants has dramatic effect on drought phenotypes and prompted new i

95 e lipid-facing binding pocket with Ala has a dramatic effect on drug sensitivity, but that the channe

96 The invasive crayfish had a dramatic effect on ecosystem structure and functioning,

97 genes; moreover, its mutation did not have a dramatic effect on either adhesion or biofilm formation.

98 hysical properties of d(CpG) steps, having a dramatic effect on enriched CpG segments, such as CpG is

99 alteration to the RNase H primer can have a dramatic effect on enzyme positioning, and discuss these

100 Here, we show that confinement has a dramatic effect on F-actin spatiotemporal organization.

101 associative or episodic memory, can exert a dramatic effect on functional network strength and effic

102 chete culture at 35 degrees C for 48 h had a dramatic effect on gene expression of this organism.

103 Our data establish that ALIX can have a dramatic effect on HIV-1 release and suggest that the ab

104 A phenotype with such a dramatic effect on host fitness is expected to provide s

105 ogy of infectious diseases, with potentially dramatic effect on host populations and knock-on effects

106 e results indicate that p53 disruption has a dramatic effect on how glioblastoma cells process topois

107 transcriptional activator; however, it has a dramatic effect on its repressive abilities.

108 robust reduction in ABCA12 expression had a dramatic effect on keratinocyte differentiation and morp

109 "compressional" strain serves to explain the dramatic effect on kinetics and composition at equilibri

110 ization strategy, medication adherence has a dramatic effect on long-term outcome.

111 ndent aspects of the c-Myc phenotype via its dramatic effect on Mdm2.

112 gime, reaction with molecular nitrogen has a dramatic effect on measured drift times and must not be

113 Here, we show that alkalinization also has a dramatic effect on membrane potential, producing a rapid

114 Moreover, Mdm30 does not have a dramatic effect on mitochondrial respiration/function, a

115 ntrol of neuromodulatory function can have a dramatic effect on motivated behavior.

116 However, neither mutation had a dramatic effect on murein hydrolase activity or autolysi

117 small interfering RNAs targeting Herc5 had a dramatic effect on overall ISG15 conjugation in human ce

118 The dramatic effect on pigment production seems to correlate

119 tuted signal transduction systems, ADP had a dramatic effect on PII regulation of two E. coli PII rec

120 group on the opposite P2/P2' position had a dramatic effect on potency depending on the size and sha

121 While the disulfide bond clearly has a dramatic effect on protein stability, it has a minor imp

122 substrate-binding groove are shown to have a dramatic effect on protein translocation through the Clp

123 ed mechanisms, the impairment of which has a dramatic effect on proximal tubule endocytosis.

124 t HDAC regulation after Rta expression has a dramatic effect on reactivation progression.

125 owed that fluorine substitution has the most dramatic effect on reactivity.

126 hat the quality of chromatography can have a dramatic effect on sample identification as well as run-

127 the sequence of cross-linking domains has a dramatic effect on self-assembly properties of elastin-l

128 g the density of the immobilized probe had a dramatic effect on sensitivity, with sparse probe monola

129 The presence of plants had a dramatic effect on SOM decomposition, increasing SOM-der

130 inus had no effect on tumor growth, it had a dramatic effect on spontaneous metastatic potential.

131 n a change of amino acid sequence can have a dramatic effect on stability, hydrogen bond network, con

132 k-irrelevant, images of visual objects had a dramatic effect on target selection, acting much like sp

133 The most dramatic effect on TBP binding was observed in a duplex

134 al 76 amino acids of the formin FMNL3 have a dramatic effect on the ability of the FH2 domain to acce

135 stream analysis methods selection can have a dramatic effect on the accuracy of taxonomic classificat

136 strated that residues at position 118 have a dramatic effect on the actions of imidacloprid (a partia

137 idation of the Ag nanoparticle surface has a dramatic effect on the adsorption, orientation, and SERS

138 The GAF-A domain protein had the most dramatic effect on the affinity of the nonactivated reco

139 that this single tumor modifier locus has a dramatic effect on the allelic preference for imbalance

140 absence of the second site of N-glycan has a dramatic effect on the barrier to transmission between h

141 e substitution of glutamate for lysine has a dramatic effect on the binding of gene 4 helicase to a D

142 The mutants D45N, D48N, and E90Q have a dramatic effect on the catalytic activity, whereas no ef

143 nitude and frequency of the noise may have a dramatic effect on the cell fitness, the quantification

144 fold higher concentration of magnesium had a dramatic effect on the crystal morphology and packing.

145 e concentration of semiquinone species has a dramatic effect on the cycling of iron between the +II a

146 ing from embryonic day 14 (E14) to E16 has a dramatic effect on the development of the sensory epithe

147 mentally that a single mismatch has indeed a dramatic effect on the distribution of intermediate (bub

148 number and location of EBUS-TBNI sites has a dramatic effect on the dose of cisplatin required for ef

149 esence of fluorous substituents can impart a dramatic effect on the efficacy of molecules used for a

150 The replacement of Gln137 by Ala also has a dramatic effect on the electrostatics of the active site

151 the topology of iso-frequency surface has a dramatic effect on the emission, propagation and scatter

152 itutive, low-level induction of qrf caused a dramatic effect on the endogenous rhythm and elevated ci

153 w that Mycobacterium tuberculosis CarD has a dramatic effect on the energetics of RNAP bound complexe

154 n as loops, whose slight change will produce dramatic effect on the entire topology.

155 binding of FK506 binding-protein, can have a dramatic effect on the excitation-contraction coupling g

156 epimerization from an L-Phe to a D-Phe has a dramatic effect on the excitatory effects of the peptide

157 sequences in the challenge virus can have a dramatic effect on the extent of apparent sterilizing im

158 The lack of MyD88-dependent signals had a dramatic effect on the extent of tissue injury, with sig

159 residue in this region of the protein, has a dramatic effect on the folding of PrP(C), resulting in a

160 re, the acylation state of P site tRNA has a dramatic effect on the frequency of intersubunit rotatio

161 Thus, electrostatic forces can have a dramatic effect on the in vivo M cell particle uptake in

162 deficiency of both p55R and p75R had a more dramatic effect on the LCMV-specific CD8 T-cell response

163 sed in serotypes 1 and 3, DHVD3 had the most dramatic effect on the level of neutralizing serum antib

164 y controlled, as loss of Kif18B has the most dramatic effect on the lifetimes of astral microtubules

165 >4-fold difference in propagation rate had a dramatic effect on the maximum obtainable backbone degre

166 solvates within the pores of the ZIF-8 has a dramatic effect on the mechanical properties of the sing

167 atic Province (CAMP), and had a particularly dramatic effect on the Modern Fauna, so an understanding

168 eters involved in variant calling can have a dramatic effect on the number of FP SNPs produced, with

169 t the conformation of the Met(20) loop has a dramatic effect on the ordering of active site hydration

170 each position of the imidazolium ring has a dramatic effect on the overall cation stability.

171 This change, in turn, has a dramatic effect on the physiology of photosynthesis duri

172 linePCl(2)](n) (2), has been found to have a dramatic effect on the polymerization.

173 Effective community size has a dramatic effect on the probability of establishing benef

174 ero-dimensional to three-dimensional, with a dramatic effect on the properties of each compound.

175 We show that the polymorphism has a dramatic effect on the proportions of neonate and adult

176 attacking low molecular-weight thiol have a dramatic effect on the protein's mechanical stability.

177 ity, rather than the assembler itself, has a dramatic effect on the quality of an assembled genome; s

178 ylammonium fluoride (TBAF) additive exerts a dramatic effect on the regioselectivity of this reaction

179 nges in the PS backbone structure can have a dramatic effect on the resulting dissociation chemistry.

180 This substitution has a dramatic effect on the Saccharomyces cerevisiae transcri

181 The substitution pattern also has a dramatic effect on the self-sensitized reactivity of the

182 d backbone conformation at position 50 had a dramatic effect on the spatial disposition of the side c

183 lecular crowding in cellular membranes has a dramatic effect on the strength of membrane protein inte

184 ppositely charged blocks are shown to have a dramatic effect on the tendency to phase separate and on

185 ication of force or tension will have a more dramatic effect on the unfolding rate).

186 e long-lived photoisomer and therefore has a dramatic effect on their photochromic properties: UV irr

187 Glycosylation of proteins can have a dramatic effect on their physical, chemical, and biologi

188 on of cap-proximal TSS nucleotides, we found dramatic effect on translation only upon stress.

189 ule inhibitor or neutralizing antibody had a dramatic effect on tumor cell growth both in vitro and i

190 Deletion of this domain had a dramatic effect on twitching motility, adhesion, and pil

191 We show that impaired VPS26 function has a dramatic effect on VPS35 levels and causes severe phenot

192 serotonergic phenotype of raphe neurons have dramatic effects on affective behaviors in rodents.

193 structural differences between AGPs can have dramatic effects on agonist activity in vivo.

194 lock, whereas those introducing rings showed dramatic effects on amiloride block.

195 all differences in protein sequence can have dramatic effects on amyloid formation.

196 city of the repeat unit was observed to have dramatic effects on antibacterial and hemolytic activiti

197 has low affinity for fructose, and has less dramatic effects on ATP levels.

198 Pulse likelihood had dramatic effects on behavior: unexpected pulses were nea

199 disruption of critical signaling factors has dramatic effects on blood vessel development.

200 rk has shown that a variety of bacteria have dramatic effects on C. elegans physiology, including imm

201 ants of negatively charged peptides also had dramatic effects on calcite crystallization; in contrast

202 he charge-reversal mutation R1229E has three dramatic effects on catalysis: (i) hydride transfer from

203 nd catalyst used in the copolymerization has dramatic effects on catalytic activity and the PPC micro

204 Here, we show that UV exposure has dramatic effects on cell cohesion and mechanical integri

205 ll proliferation and cell migration but more dramatic effects on cell transformation as assessed by g

206 Protein aggregation can have dramatic effects on cellular function and plays a causat

207 arrowD(448) cleavage site in DSP-PP(240) had dramatic effects on cleavage efficiency by the endogenou

208 TLR9 and TLR7 also had dramatic effects on clinical disease in lupus-prone mice

209 component function that in combination have dramatic effects on complement activity and disease risk

210 d small changes in expression level can have dramatic effects on differentiation or oncogenesis.

211 on nucleotide-dependent dimerization but had dramatic effects on DNA binding.

212 r revealed two cis-acting elements that have dramatic effects on dnaA gene expression.

213 fliC promoter in vitro, suggesting that the dramatic effects on expression of those genes in vivo ar

214 Changes in nutrient dose have dramatic effects on gene expression and development.

215 telomeres at the nuclear periphery can have dramatic effects on gene expression by establishment of

216 phages and other immune cells known to exert dramatic effects on glucose homeostasis.

217 changes in hypothalamic resistin action have dramatic effects on GP and proinflammatory cytokine expr

218 In contrast to its dramatic effects on growth and endoreplication, dMyc is

219 tructural variants shape the epigenome, with dramatic effects on immunity genes.

220 es with these radiolabeling handles can have dramatic effects on important properties such as particl

221 n and that these conformational changes have dramatic effects on interaction with cochaperone protein

222 that different GPI anchor sequences can have dramatic effects on localization of the proteins and hel

223 p67 ablation had dramatic effects on lysosomal morphology with gross enla

224 nger RNA modifications and RNA editing, with dramatic effects on mammalian transcriptomes.

225 hat manipulations to synaptic ribbons caused dramatic effects on mEPSC-like (mlEPSC) amplitude and fr

226 At lower [InsP3], ATP had dramatic effects on mInsP3R-2 Po, but unlike the rInsP3R

227 demonstrate that NF1 germline mutations have dramatic effects on neurofibromin expression.

228 Androgens have dramatic effects on neuronal structure and function in h

229 Lack of Rac1 had dramatic effects on nonconfluent cells, which were elong

230 he nuclear lamina of animal cell nuclei have dramatic effects on nuclear structure and gene expressio

231 hibitory neurons with viral vectors all have dramatic effects on pain and itch.

232 substitution of two active site residues had dramatic effects on PCO4 function both in vitro and in v

233 e find that valve structural properties have dramatic effects on performance, and that valves with a

234 Both light and temperature have dramatic effects on plant development.

235 duced into RB69pol, only L415A and L415G had dramatic effects on pre-steady-state kinetic parameters,

236 ditions, thrombin and fibrinogen gamma' have dramatic effects on protofibril content and that protein

237 ing global impacts and will continue to have dramatic effects on public health for years to come.

238 s on titer and cleavage specificity can have dramatic effects on rates of PPT generation and utilizat

239 s motif between mammalian iGluR subtypes has dramatic effects on receptor function.

240 flap endonuclease 1 (h-FEN1) mutations have dramatic effects on repeat instability.

241 ttling can block cellular proliferation, the dramatic effects on ribosome export occur prior to cell

242 temperature-dependent stem development with dramatic effects on stem width.

243 Virus infections have dramatic effects on structural and morphological charact

244 dopamine receptor expression levels can have dramatic effects on synaptic plasticity in the prefronta

245 ed from amyloid precursor protein (APP) have dramatic effects on synaptic transmission before the ons

246 Finally, RRF depletion has dramatic effects on the activity of ribosome rescue fact

247 vaccination--during the neonatal period has dramatic effects on the adult Ab response and modifies t

248 ogether with closely related Rev-erbbeta has dramatic effects on the cell-autonomous clock as well as

249 e conflicts are widespread, sometimes having dramatic effects on the colony.

250 ive C-terminal residues of the peptide cause dramatic effects on the concentration dependence, yieldi

251 restrial herbivores, such as elephants, have dramatic effects on the ecosystems they inhabit and at h

252 erlayer registry between the layers can have dramatic effects on the electronic properties: for examp

253 the C(3)HC(4) zinc RING finger of bICP0 has dramatic effects on the growth properties of BHV-1.

254 ate bacterial symbiont (Buchnera), which has dramatic effects on the heat tolerance of pea aphid host

255 in an animal's spatial environment can have dramatic effects on the hippocampus, an area of the brai

256 se results demonstrate that TB treatment has dramatic effects on the intestinal microbiome and highli

257 ven so, we did not find the mutation had any dramatic effects on the level of DNA repair in mitosis.

258 tromagnetic field moments; these can lead to dramatic effects on the light propagation, such as negat

259 n conclusion, whereas the Jimpy mutation has dramatic effects on the myelination of retinal ganglion

260 cross space and time, and this variation has dramatic effects on the physiology of living cells.

261 of many weak epistatic interactions can have dramatic effects on the population structure.

262 at Mn(2+), in comparison with Mg(2+), showed dramatic effects on the priming activity of MiniRT2 as w

263 Thermal variations can exert dramatic effects on the rates of enzymes.

264 chelating ligand and the metal catalyst had dramatic effects on the regioselectivity during the init

265 e inputs can, in principle, have diverse and dramatic effects on the reliability of the resulting com

266 wo nonselective agonists, although they have dramatic effects on the S1P1-selective agonists.

267 avian infectious bronchitis virus (IBV) has dramatic effects on the secretory system which require r

268 avian infectious bronchitis virus (IBV) has dramatic effects on the secretory system, which require

269 ymmetry in competitive interactions can have dramatic effects on the speed of the life history.

270 placement of Cu centers within Sav that have dramatic effects on the structural and physical properti

271 ractions between bacteria and fungi can have dramatic effects on the survival, colonization and patho

272 igh phenotypic trait variability, leading to dramatic effects on the tempo and mode of diversificatio

273 al activity of the PTEN phosphatase can have dramatic effects on the therapeutic sensitivity of breas

274 of WT-hbeta(2)m into amyloid, which lead to dramatic effects on the time course of assembly.

275 Abnormal visual input during development has dramatic effects on the visual system.

276 lling evidence that closing schools can have dramatic effects on transmission of pandemic influenza.

277 More dramatic effects on TRF1 and TRF2 binding were observed

278 es in Arabidopsis thaliana, vt2 mutants have dramatic effects on vegetative and reproductive developm

279 yet APDS2 largely phenocopies APDS1 without dramatic effects outside the immune system.

280 its it synthesis from NAC/cysteine, having a dramatic effect over the glutathione system.

281 rthermore, they demonstrate that many of the dramatic effects previously reported by pharmacological

282 first time that denileukin diftitox has also dramatic effects regarding the pathology of type 1 diabe

283 ing empty bed contact time (EBCT), with more dramatic effects seen for the more strongly adsorbing WF

284 individually, the modifier subunit had more dramatic effects than the catalytic subunit.

285 and phylogenetic analyses have uncovered the dramatic effect that the use of antibiotics has had on s

286 Deletion of ATG4.2 had a more dramatic effect upon autophagy than did deletion of ATG4

287 ely subtle changes in the capsule may have a dramatic effect upon disease potential.

288 Varying the polarity of the solvent has a dramatic effect upon the oleophobic/oleophylic interacti

289 on of the substituted proline residues had a dramatic effect upon the self-assembly of the correspond

290 d changes in timing of reproduction can have dramatic effects upon the success of fish populations an

291 The most dramatic effect was observed for mutation of an invarian

292 The most dramatic effect was observed with the W31A variant, whic

293 H4 tails were simultaneously clipped, a more dramatic effect was seen than when only H3 or H4 tails w

294 the number of KSHV genome copies, whereas no dramatic effect was seen with CENP-F knockdown.

295 A similar, if less dramatic, effect was observed in studies less than 6 mon

296 To understand the mechanisms behind such dramatic effects, we isolated a mutant that is altered i

297 Such dramatic effects were likely due to an essential role of

298 eakly affected by Ala substitutions, whereas dramatic effects were observed for the higher permeabili

299 The most dramatic effects were on the germ-line-associated Dnmt3A

300 Overexpression of PDI had the most dramatic effect with a 100% increase in the intracellula