ライフサイエンスコーパス: drastic

1 me maintenance (MCM) helicase in addition to drastic accumulation of sumoylated nucleolar RENT and in

2 Svbp knockout mice exhibit drastic accumulation of tyrosinated tubulin and a reduct

3 receptor (OR) co-receptor, Orco, results in drastic AL reductions in ants [13, 14], but not in Droso

4 ns of the hexon and penton are mediated by a drastic alpha-helix-to-beta-strand structural transition

5 ting a comparable effect to that of the most drastic ALS-causing mutations known.

6 ed, demonstrating site selectivity without a drastic alteration of electronic structure.

7 Rapid adaptive changes can result from the drastic alterations humans impose on ecosystems.

8 rvers were often completely unaware of these drastic alterations to their visual world.

9 es in this issue of Cell begin to reveal the drastic and complex effects of fasting and severe calori

10 alysis suggests that the division may be too drastic and misleading, because it puts within the same

11 Our findings point to potential drastic and rapid consequences of climate change on mult

12 ropogenic warming and the immediate need for drastic and sustained cuts in carbon emissions.

13 Adding ligands to molecules can have drastic and unforeseen consequences in the final product

14 domestication and breeding have resulted in drastic and well documented changes in aboveground trait

15 space only to heuristic methods based on the drastic approximation of relying on the geometry of the

16 the pigments and volatile changes are not as drastic as observed at 75 and 90min of boiling.

17 r S-II (TFIIS)-dependent RNA cleavage, or as drastic as premature transcription termination or degrad

18 tterns across behavioral clusters, including drastic, atypical changes.

19 Rabies virus induces drastic behaviour modifications in infected hosts.

20 the initiating step of HER and explained the drastic catalytic activity difference of the two POM@MOF

21 to use these cells in vivo have resulted in drastic cell death caused by mechanical, metabolic, and/

22 This drastic change in domain wall kinetics does not originat

23 Upon a drastic change in environmental illumination, zebrafish

24 rich bird guano, C. neoformans experiences a drastic change in nutrient availability during host infe

25 r, molecular dynamics simulations revealed a drastic change in the dynamics and a movement of the int

26 Such a drastic change in the intermediate coverage on the Ru su

27 es calculations show that this is due to the drastic change in the local oxygen coordination environm

28 ect to Cytochalasin D treatment to provoke a drastic change in the power law coefficient and to demon

29 e addition of water to the system leads to a drastic change in the selectivity of methane activation

30 rough in targeted cancer therapy and marks a drastic change in the treatment of non-small cell lung c

31 (EHT) is a key developmental process where a drastic change of endothelial cell morphology leads to t

32 A capsize, namely a drastic change of polarization to the perpendicular dire

33 A drastic change of the shell morphology was observed by c

34 These drastic changes affect moderately the transcription but

35 The high damage potential of such drastic changes between flood and drought conditions pos

36 male mice after disease onset, whereas these drastic changes did not occur in male mice.

37 f MECII impaired spatial memory and elicited drastic changes in CA1 place cells in a familiar environ

38 id within the amelogenin protein can lead to drastic changes in enamel phenotype, resulting in amelog

39 move expression noise rather than by causing drastic changes in expression levels.

40 ts following gene duplication result in more drastic changes in expression properties than shifts wit

41 hat small changes in these functions lead to drastic changes in extinction dynamics.

42 Drastic changes in gene expression occur after adult fem

43 uent occurrence in CRC, and the accompanying drastic changes in gene expression profiles play fundame

44 metrics: assemblage metrics may average out drastic changes in individual populations.

45 Macrophage polarization is accompanied by drastic changes in L-arginine metabolism.

46 Photosynthetic organisms are exposed to drastic changes in light conditions, which can affect th

47 Small changes in gene expression can lead to drastic changes in lineage commitment, cellular function

48 ponsible for a worldwide pandemic has forced drastic changes in medical practice in an alarmingly sho

49 escence, a reversible cell cycle arrest with drastic changes in metabolism allowing cells to remain v

50 Drastic changes in modern environments and lifestyles ha

51 Additionally, in aged cells, we observe drastic changes in organellar volume, leading to crowdin

52 they can be incorporated into diets without drastic changes in preparation methods.

53 e only a subset of these variants results in drastic changes in proteins, we focused on variations th

54 n species (ROS) and oxidative stress exhibit drastic changes in RGPs.

55 pirical evidence regarding the occurrence of drastic changes in RUE (assessment of the timing, the di

56 The second case study displays drastic changes in specific erythrocyte metabolite pools

57 the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a

58 This rearrangement is accompanied by drastic changes in the (11)B and (29)Si NMR chemical shi

59 This is accompanied by drastic changes in the degree of sister chromatid intert

60 allosteric pocket upon BH4 binding result in drastic changes in the quaternary structure of the enzym

61 other hand, generalize across comparatively drastic changes in the sensory input all the time.

62 Our results indicate that there are drastic changes in the specific neurons activated at dif

63 trary to earlier human findings, we found no drastic changes in the spontaneous discharge of the well

64 nety-nine percent of Treg depletion provoked drastic changes in the tumor microenvironment, such as s

65 subtle structural modification brings about drastic changes in their photophysical and supramolecula

66 des of melt pools enables crystals to follow drastic changes in thermal gradient across adjacent melt

67 achieving perceptual stability, despite the drastic changes introduced by oculomotor behavior in rea

68 Drastic changes of organization, such as epithelial-mese

69 The dynamics of the state of charge induces drastic changes of the microstructure and properties of

70 Studies of 93 atoms predict drastic changes to ground-state electronic configuration

71 3 Lys27 acetylation (H3K27ac) exhibited most drastic changes, accumulating in two nuclear foci in the

72 e, the integrin expression profile undergoes drastic changes.

73 The other 2 clusters displayed more drastic changes: nsCAI frequency in cluster 2 (20% of th

74 pramolecular configuration clearly reveals a drastic chiral phase transition from an enantiomeric chi

75 knockdown in Drosophila was associated with drastic climbing impairment.

76 ntages of nanoscale architectures, including drastic concentration of electric field, possibility of

77 93.5%) of moldy plus fermented grains, named drastic conditions (DC).

78 More drastic conditions like higher flow rate and processing

79 Prions result from a drastic conformational change of the host-encoded cellul

80 hanisms, while if PSI is affected, there are drastic consequences on growth.

81 y and directed cell migration, which is in a drastic contrast to the consequences of Kindlin-3 knocko

82 This study shows that the drastic control measures implemented in China substantia

83 that interpolates between wild-type and more drastic conventional mutations, reinforcing the evaluati

84 perovskites under high pressure: during the drastic cubic-orthorhombic structural transformation at

85 very low intracellular forces by inducing a drastic cytoskeleton remodeling, in response to signalin

86 astewater treatment since it causes a quick, drastic decay of organic matter content.

87 on conditions, and found reduced pH led to a drastic decline in net calcification of living corals to

88 flow among L. auriculata populations showed drastic declines in comparison with historical gene flow

89 ard and headwater-ward range contraction and drastic declines in habitat suitability for most extant

90 stat experiments with whole cells revealed a drastic decrease in isotope fractionation with declining

91 A drastic decrease in lattice thermal conductivity down be

92 Renal transplant was marked by a drastic decrease in levels of catalytic IgG over 3 mo fo

93 There has been a drastic decrease in liver donors.

94 A drastic decrease in phenolic content was observed in Sem

95 This leads to a drastic decrease in the electrical resistivity and therm

96 Chelation of Na(+) leads to drastic decrease in the formation rate of C(2+) products

97 e rapid delayed rectifier K(+) current and a drastic decrease in the slow delayed rectifier K(+) curr

98 In the bending curves, a drastic decrease in the viscosity of the modified starch

99 tract (FRT) during ART that result in such a drastic decrease in transmission were not studied and re

100 n knockdown and overexpression resulted in a drastic decrease of MT minus ends and a concomitant incr

101 Experimental results have revealed a drastic decrease of the friction coefficient for velocit

102 ations during the intense drought period and drastic decreasing in rainy period.

103 Importantly, myosin-18B deletion resulted in drastic defects in the concatenation and persistent asso

104 for signaling, were not exchangeable without drastic deficiencies in folding, plasma membrane targeti

105 ngly, we observe that human DHHC20 induces a drastic deformation in the membrane, particularly on the

106 1 artificial microRNA lines phenotype show a drastic delay in the grain germination process.

107 lation imbalanced Fermi gas, but with a more drastic departure from the regular 3D balanced case, fea

108 such episodes have the potential to induce a drastic destabilization of the Sahelian agroecosystem.

109 the R805W mutation appeared to have the most drastic detrimental effect on the structure and organiza

110 clear polarization relaxometry, we show that drastic differences exist in water motion within a dista

111 the results of the former approach revealed drastic differences in chemical behavior of extended str

112 mouse embryonic fibroblasts (MEFs) and found drastic differences in multiple cellular functions durin

113 alyses of the drivers and correlates of such drastic differences in substitution rates across a diver

114 veral strains could be achieved, we observed drastic differences in the functionality of these protei

115 Antibiotic-treated mice displayed drastic, dose-dependent mortality after MI.

116 hat administration of 50 uM ouabain causes a drastic drop in dopamine uptake rate, confirmed by eleva

117 It also brought about a drastic drop in pH leading to greater proteolytic activi

118 ock-out (KO) mice, betaOHB recovers from the drastic drop in specific dopaminergic and myelin markers

119 This development has been facilitated by drastic drops in cost, advances in technology and concer

120 We found a drastic dysregulation of the expression of mature tRFs i

121 lizes both PrP variants, but produces a more drastic effect in the less stable GHaPrP.

122 ther show that specific W34 mutations have a drastic effect on D97 and proton transfer mediated throu

123 ages a minute change in the image can have a drastic effect on recognition, thus identifying features

124 orporation of a few percent of N atoms has a drastic effect on the electronic structure of the alloys

125 The scaling exponent has a drastic effect on the optimal design of shell shapes.

126 e acid or base-disproportionation-can have a drastic effect on the solubility and consequently the bi

127 nstrate how disruption of this interface has drastic effects on both the oligomerization and function

128 well as its interplay with the ADC can have drastic effects on cell apoptosis versus survival.

129 tween torsional and vibronic modes and their drastic effects on charge-transfer dynamics, thus settin

130 Food storage and preparation have drastic effects on the chemical composition of foods.

131 ns in key biosynthetic enzymes can result in drastic effects on the composition of chemical signals.

132 building blocks of these assemblies can have drastic effects upon the final morphology or function of

133 Without drastic efforts to reduce carbon emissions and mitigate

134 are in line with the experimentally observed drastic, eight-fold conductivity enhancement.

135 We observe a drastic elastic-mechanical softening in highly doped BDD

136 d in the mouse DC by the YSK12-MEND showed a drastic enhancement in cytokine production, resulting in

137 The drastic enhancement in mechanical properties is found to

138 A drastic enhancement in the reactivity of the cupric supe

139 of torsion in a rotational DAC (RDAC) offers drastic enhancement of the pressure self-focusing effect

140 In the presence of drastic environmental changes, Hsp70 plays a key dual ro

141 Ongoing global changes apply drastic environmental forcing onto Arctic marine ecosyst

142 primed pluripotent states is accompanied by drastic epigenetic rearrangements.

143 This binding event results in a drastic expansion of the rest of the uOMP, which has man

144 enerate elements in mRNAs and have undergone drastic expansions in higher metazoan genomes.

145 oxidant, showing that samples that underwent drastic extraction processes could not tolerate addition

146 ant and show reduced NHEJ efficiency, with a drastic failure to up-regulate RAD51 expression and mani

147 ance between strong global demethylation and drastic focused remethylation.

148 allenges humanity faces, yet the field faces drastic funding cuts as society realigns its priorities

149 g the curling edge, followed by an immediate drastic gasification of L-N2 , further peeling off h-BN.

150 This drastic genome reduction has been achieved through massi

151 tivation of hundreds of enhancers along with drastic genome-wide reduction of HNF4A and HNF4G occupan

152 HCMV can remain relatively stable or undergo drastic genomic changes that are suggestive of the emerg

153 ng to 2 degrees C, however in the long term, drastic GHG emissions reductions are required under any

154 sphate transporter (pgk3.2 tpt3) displayed a drastic growth phenotype, but they were viable.

155 e cover, which can partly explain the recent drastic ice reduction in the Arctic Ocean.

156 anization on species, with studies revealing drastic impacts on community composition, gene flow, beh

157 is highly selective and it is coupled with a drastic impairment at the opposite foveal location, just

158 not being perfect, our new approach yields a drastic improvement in the accuracy of gene boundaries a

159 sults in extensive twinning and a subsequent drastic improvement in the yield (>85%) of formation of

160 g the stoichiometry of these genes can yield drastic improvements in performance.

161 Drastic improvements in Raman efficiencies are consisten

162 e optimal scan speed was used, although more drastic improvements were observed for other values of D

163 was found to exhibit the best results, with drastic improvements when using Bayesian inference as co

164 tein) in PCa samples, and this is especially drastic in metastatic and/or high Gleason score tumor sa

165 s motoneuron firing pattern, which were more drastic in MLF of animals.

166 The increase was more drastic in St. Croix than in Fort Lauderdale, where 25%

167 This contrast is found to be even more drastic in the case of their peripherally annulated coun

168 This effect is drastic in the primary visual cortex (V1), where locomot

169 andscape is progressively established with a drastic increase at the 8-cell stage.

170 Gna13-deficiency triggers a drastic increase in both osteoclast number and activity

171 iferous tubules of C/C testes, we recorded a drastic increase in cells with DNA fragmentation.

172 By tuning the concentration of Zn, a drastic increase in CH(4) selectivity [~70% Faradaic eff

173 evolutionary processes may account for this drastic increase in gene number on the Y.

174 ulmonary mycobacterial infection, we found a drastic increase in l-citrulline in the lung, even thoug

175 he linker-exchanged ZIF-8 membranes showed a drastic increase in propylene permeance by about four ti

176 Interestingly, there was a drastic increase in spare mitochondrial respiratory capa

177 With the drastic increase in the cost of aerosolized RBV, we aime

178 Here we report advances that lead to a drastic increase in the measurement throughput of multip

179 A drastic increase in the pH was observed until the 3rd we

180 over, and it was found that there had been a drastic increase in the preference of CBCT over OPG in r

181 standing of this invasion is why there was a drastic increase in the proportion of mammals of North A

182 Notably, despite the drastic increase in the ratio of male to female germ cel

183 lung consolidation were found on CT, with a drastic increase in uptake for both (18)F-FDS and (18)F-

184 in the external magnetic field results in a drastic increase of the inductive voltage, as well as in

185 evealed that the inclusion of a cation had a drastic influence on the obtained results.

186 controls, EtOH-exposed hepatocytes showed a drastic inhibition in beta-AR/cAMP-induced LD breakdown

187 In the drastic kinase-off lesion of CCW B, the alpha1 helices u

188 phenotypes, the triple uch mutant displays a drastic lengthening of period at high temperatures that

189 tectomy is associated with overtreatment and drastic lifestyle consequences.

190 enging goal, which will ultimately lead to a drastic limitation of the experimental tests required to

191 own in cultured hippocampal neurons caused a drastic loss of both pre- and post-synaptic components o

192 CHH methylation during seed development and drastic loss of CHH methylation during germination.

193 was confirmed by mutation to Ala, leading to drastic loss of enzymatic activity.

194 up to 25 T, with the aggregates showing more drastic magnetic field sensitivities depending on the in

195 ck of experimental evidence obtained without drastic manipulation of the midgut and its content.

196 us disease 2019 (COVID-19) in Italy prompted drastic measures for transmission containment.

197 VID-19 pandemic, many governments have taken drastic measures to avoid an overflow of intensive care

198 This transition requires drastic metabolic shifts, insinuating the capacity of HS

199 tivity in S. aureus USA300 (Deltatkt) led to drastic metabolomic changes.

200 In particular, the origins behind the drastic microstructural changes observed upon modificati

201 ate the biogeographical consequences of such drastic migratory shifts, we performed an in-depth study

202 le intermediates and this contributes to the drastic mismatch in selectivities.

203 Stem cells undergo drastic morphological alterations during differentiation

204 with nanoceria at pH 9, P. aeruginosa showed drastic morphological changes as a result of cellular st

205 We show that scales undergo drastic morphological changes during development, from a

206 ve movements of calsequestrin accompanied by drastic morphological SR changes in fully depleted cells

207 DRD1 binding to the DR complex induces a drastic movement of a DMS3 coiled-coil helix bundle.

208 Conversely, AEBP2 binding results in a drastic movement of the C2 domain, disrupting the intrin

209 ting along the array plane, which leads to a drastic narrowing of plasmon resonance lineshapes (down

210 lycolipids and phospholipids, supporting the drastic need of acyls for TAG assembly.

211 Finally, drastic neuronal loss caused manifestations mimicking hu

212 ent on the emissions scenario, with the most drastic one shifting 38% of the current distribution by

213 NPIs can be as effective as more intrusive, drastic, ones (for example, a national lockdown).

214 ying molecular defect provides hope that the drastic peripheral neurodegeneration characteristic of F

215 ht control of the protein environment allows drastic perturbations in the electronic structure of Cu(

216 exodus of neural lineages out of the CNS and drastic perturbations to CNS structure.

217 Such a drastic phase change has been theoretically highlighted

218 Arabidopsis thaliana, the xylem undergoes a drastic phase transition from a parenchyma-producing pha

219 -down of Kmt6 in the KMT6(kd) strain shows a drastic phenotype affecting fungal growth and developmen

220 However, these drastic phenotypes are suppressed when EXECUTER1 (EX1) i

221 cute glucose starvation, yeast cells undergo drastic physiological and metabolic changes and reestabl

222 h SCI changed to the lesion site, indicating drastic post-injury hemodynamic changes in the spinal co

223 in case counts without the implementation of drastic public health interventions.

224 ors such as azobisisobutyronitrile lead to a drastic rate enhancement.

225 The formation of CDRs involves a drastic rearrangement of the cytoskeleton, which is regu

226 tin histochemistry to show that PNNs undergo drastic reconstruction during the metamorphic transition

227 Additionally, A10B(lpr) mice have a drastic reduction in autoimmune anti-dsDNA Ab production

228 ELATED PROTEIN (KRP), which may underlie the drastic reduction in cell division activity in both shoo

229 d to exposure to these external stimuli by a drastic reduction in COF layer correlation, long-range o

230 uffice for optimal performance, leading to a drastic reduction in computational requirements.

231 Due to the drastic reduction in device thickness, we are able to ut

232 We observe a drastic reduction in diversity during expansions when ye

233 Mcl and Mincle on myeloid cells exhibited a drastic reduction in EAE incidence.

234 rmation across data sites, with a consequent drastic reduction in estimation uncertainty; 2) it permi

235 ments in sequencing technology have led to a drastic reduction in genome sequencing costs.

236 acterized by very small plaque formation and drastic reduction in infectious virus production, while

237 not observed in our model, which presented a drastic reduction in lactate generation and release by i

238 The result would likely be a drastic reduction in liver waitlist deaths for young chi

239 The dieback was accompanied by a drastic reduction in local invertebrate biodiversity.

240 In general, drastic reduction in molecular diversity was observed in

241 The resulting Ala96Leu mutant showed a drastic reduction in oxidase activity using molecular ox

242 ed by compromised epidermal differentiation, drastic reduction in profilaggrin processing, reduced la

243 Using a USA300 mroQ mutant, we observed a drastic reduction in proteolysis, hemolysis, and pigment

244 The Sox17(+/-) gallbladder also showed a drastic reduction in sonic hedgehog expression, leading

245 There was also a drastic reduction in the failure rate for underrepresent

246 an onset potential of 125 mV, representing a drastic reduction in the kinetic overpotential.

247 monas syringae pv tomato DC3000 results in a drastic reduction in the levels of ubiquitinated XBAT35.

248 a significant decrease in infection, with a drastic reduction in the number of lytic plaques in MAL-

249 This instability was caused by a drastic reduction in the sodium current, accompanied by

250 transmetalation of TPE-boronic acid causing drastic reduction in the solubility of the resulting pro

251 We show that the lack of FtsH1/3 leads to a drastic reduction in the transcriptional response to nut

252 Western blot analyses revealed drastic reduction of alpha-toxin levels in the culture s

253 AMHD1 hydrolyzes Ara-CTP, which results in a drastic reduction of Ara-CTP in leukemic cells.

254 ells, such photorelease was accompanied by a drastic reduction of cell growth, not only when the cell

255 long-range migration of Cu(+) and produces a drastic reduction of Cu(+) ion migration by nearly two o

256 nificantly better to GC than Pt, and allowed drastic reduction of electrode size while maintaining sa

257 ads to variable skipping of exon 20 and to a drastic reduction of ELP1 in the nervous system.

258 We demonstrate that the approach allows drastic reduction of false positive quantitations and id

259 ions in VLCFA-containing lipid species and a drastic reduction of lipid droplets (LDs) that play a cr

260 ated cortical cell divisions, resulting in a drastic reduction of nodule numbers.

261 ith transcription elongation, resulting in a drastic reduction of pre-rRNA and pre-tRNA synthesis, th

262 econdary flightlessness, a process involving drastic reduction of the flight muscles and enlargement

263 osphate synthesis, to accumulate Mn and 2) a drastic reduction of the Mn storage capacity in P-defici

264 nge used for classical CIU experiments; (ii) drastic reduction of the overall data collection time pr

265 lassified Ruminococcaceae in parallel with a drastic reduction of the presence of Faecalibacterium pr

266 Results have shown that a drastic reduction of the reflux rate at an early stage o

267 model, integrin alpha11-deficiency led to a drastic reduction of tumor progression and metastasis.

268 blasts of five affected individuals showed a drastic reduction or loss of MADD.

269 C by 2100, and possibly below 1.5 degrees C, drastic reductions of greenhouse gas emissions are manda

270 the quantitative nature of XRNAX, we observe drastic remodeling of the RNA-bound proteome during arse

271 ycle of human cytomegalovirus (CMV) leads to drastic reorganization of domains in the host cell nucle

272 Due to the drastic reorganization of SAMN surface, the prepared mag

273 In mammals, chromatin organization undergoes drastic reprogramming after fertilization.

274 ay scattering and transport reveal that this drastic response originates from the complete strain-tun

275 Similar, but even more drastic, results were observed with two-motor complexes

276 This occurrence required a drastic revision of the synthetic design that ultimately

277 is compatible with a gradual, rather than a drastic saltation event.

278 This drastic scaling of the magnetic dynamics tracks monotoni

279 icrobial abundance and diversity change over drastic seasonal transitions and how ice cover may affec

280 tion of bilaterian features, or as a case of drastic secondary loss of complexity.

281 ibition of oxidative rancidity and displayed drastic secondary structure changes.

282 Intriguingly, this A24R variant underwent a drastic selective sweep during passaging, despite enhanc

283 showed that in the cis-variant FlrC(C)-R349A drastic shift of Walker A encroached ATP-binding site, w

284 D-DNP can provide drastic signal improvements in NMR signal amplitudes, pe

285 This approach produces a drastic signal increase in RNA FISH samples without incr

286 The emergence of centromeres resulted in a drastic size increase due to repeat accumulation, and do

287 lex virus 1 (HSV-1) infection results in the drastic spatial reorganization of the cellular chaperone

288 Altogether, our results demonstrate a drastic splicing machinery-associated molecular dysregul

289 DCAF1 deletion leads to a drastic stabilization of p53 protein, which can be attri

290 However, blocking the same routes had drastic strain-specific consequences on the establishmen

291 ers, whose mechanism entails one of the most drastic structural changes known.

292 ed enhancers and super-enhancers, leading to drastic suppression of driver oncogenes and HCC tumorige

293 xtravasation potential, with a corresponding drastic suppression of metastatic nodule formation in th

294 's disease (AD) but at the same time display drastic synapse loss, even in the absence of amyloid.

295 thdrawal from drugs has been shown to induce drastic synaptic changes in neuronal populations associa

296 This study shows how drastic the effect will influence a database, depending

297 k presents a general mechanism for achieving drastic topological remodeling in cellular membranes.

298 riments and optical modeling demonstrate the drastic type I/type II transition.

299 A drastic visible change in color as well as wetting of Ag

300 Drastic visual changes and internal biochemical alterati