ライフサイエンスコーパス: drastically

1 g from wheat-related disorders has increased drastically.

2 while the performance of reflectors degrades drastically.

3 However, projections can differ drastically.

4 mooth muscle layer, the myometrium, increase drastically.

5 Virtual Screening (VS) methods can drastically accelerate global drug discovery processes.

6 voltage-dependent gating, as N-Cap deletion drastically accelerates hERG channel deactivation.

7 ng a diglycine (GG) to an antibiotic prodrug drastically accelerates intrabacterial ester-bond hydrol

8 ticular, the VWD type 2A Gly1629Glu mutation drastically accelerates the proteolytic cleavage activit

9 ltural familiarity affected the correlations drastically across both musicians and non-musicians, but

10 rryl species with or without Lewis acid vary drastically; addition of LutH(+) to F(8)Cmpd-II (F(8) =

11 how how distinct hydrogen-bond modifications drastically affect the solubility, aggregation behavior,

12 Aggregation of organic molecules can drastically affect their physicochemical properties.

13 ter than at steady-state and HSC function is drastically affected.

14 echnique to maintain the shelf life, without drastically affecting the nutritional and functional qua

15 It was shown that N-hydroxyphthalimide drastically affects the oxidative properties of t-BuOOt-

16 onstrating that some allopatric microbes can drastically alleviate gene essentialities.

17 ct on the global AT1R structure, most nsSNPs drastically alter a sub-set of ARBs affinity to the AT1R

18 stablished prostate cancer organoids did not drastically alter AR binding, H3K27ac enhancer, or open

19 re exposed to a mechanical stimulus known to drastically alter cell deformability (i.e., prior shear

20 tiation or the synthesis of alarmones, which drastically alter cell physiology.

21 High pressure can drastically alter chemical bonding and produce exotic co

22 there is growing evidence these declines can drastically alter ecological food webs.

23 s of anomalously warm ocean temperatures-can drastically alter ocean ecosystems, with profound ecolog

24 talyzed polymerizations of alpha-olefins can drastically alter reactivity.

25 h other biogeochemically active elements can drastically alter Se oxidation state and form, impacting

26 nces and that the coupling to the cavity can drastically alter the characteristic charge-transfer beh

27 Diffusible small molecule microbial hormones drastically alter the expression profiles of antibiotics

28 glia identity and that in vitro environments drastically alter the human microglia transcriptome.

29 ers, we found that sulfation and sialylation drastically alter the MS(2) fragmentation pattern of gly

30 In summary, single-residue substitutions can drastically alter the processing and immunogenicity of P

31 cing a crosslinking agent, it is possible to drastically alter the visual appearance of the HPC mesop

32 modification of drugs by the microbiome can drastically alter their clinical effectiveness, with the

33 addition of each extra layer of graphene can drastically alter their electronic and structural proper

34 element in a compound can appreciably, even drastically, alter the NMR shifts of the nearby nuclei.

35 piratory syndrome coronavirus 2 pandemic has drastically altered all facets of clinical care and rese

36 as well as other chemical properties can be drastically altered by modifying the vacuum fluctuations

37 A drastically altered chemistry was recently discovered in

38 h T. brucei and found that infected mice had drastically altered sleep patterns.

39 fibroblasts, but not white pulp fibroblasts, drastically altered the RPM network without altering cir

40 Though immunologic parameters are drastically altered with ATG induction, long-term clinic

41 peratures across LMPA melting points thereby drastically altering stiffness.

42 , which act as pinning sites for boundaries, drastically alters the coarsening behaviour of the syste

43 rophobic mutation on the cyt cb(562) surface drastically alters the outcome of metal-directed oligome

44 e models and liver-specific Prmt1 deficiency drastically ameliorated diabetic hyperglycemia.

45 mouse, we fully restored CD8(+) T cells and drastically ameliorated STING-associated lung disease.

46 C bond-cleavage events have the potential to drastically and rapidly remodel skeletal frameworks.

47 light exposure time, whereas the difference drastically approaches to zero during the cooling period

48 (2)/year before 1400 years ago but increased drastically around 600 years ago, forming the entire Cam

49 red lysozyme diffusion coefficient decreased drastically as a function of increasing ionic strength (

50 Fire intervals are projected to decline drastically as climate warms, and forests that reburn be

51 CB (1) -WT, but their distribution decreased drastically at 300 nm of the active zone.

52 Here we extend such experimentation drastically, beyond dyads and beyond laboratory walls, t

53 -sensitive neurons, and these responses were drastically blunted in Trpm8 KO mice or after the applic

54 The QCL mode then drastically boosts the time resolution from tens of mill

55 es, and that differences in halogenation can drastically change crystallization kinetics and device s

56 al transformations during song learning that drastically change how neural commands are translated in

57 al transformations during song learning that drastically change how neural commands are translated in

58 as monomeric motifs to develop polymers that drastically change their properties in response to force

59 tic Bax protein to OxPls-containing vesicles drastically changed the membranes' dynamic behavior, alm

60 Modern technology has drastically changed the way we interact and consume info

61 tored via NMR) with an LED (lambda = 365 nm) drastically changes the chemical environment around the

62 Variation in MASC formulation drastically changes the mechanical properties of printed

63 nt species that persist in environments with drastically changing herbivore pressure, for example ove

64 Climate change is drastically changing the timing of biological events acr

65 Wild boar (Sus scrofa) drastically colonized mainland Eurasia and North Africa,

66 back, the decreased conductivity can lead to drastically decreased cell signals and it is hardly to p

67 niaceae) upon stress induction, resulting in drastically decreased host energy harvest and, ultimatel

68 immune responses, such as phagocytosis, are drastically decreased in cavefish.

69 he total Pb concentrations in Bordeaux wines drastically decreased over the previous 50 years with a

70 nt tumour markers, and its silencing in vivo drastically decreased tumour development and progression

71 ntil genotypes pardina, red chief and precoz drastically decreased when treated with As at 6 mg kg(-1

72 of tumor-infiltrating dendritic cells (TIDC) drastically decreased with time.

73 genetic inactivation of GMCSF in CAR T-cells drastically decreases available GMCSF and abolishes macr

74 Phosphorylation of ZmC(4)-NADP-ME drastically decreases its activity as shown by the low r

75 monstrated at 2.5 K, and the spin Hall angle drastically decreases to 0.3-0.5 as the temperature incr

76 ly for large ITO electrodes, the sensitivity drastically decreases.

77 r monolayer-protected metal clusters (MPCs), drastically depend on their atomic structure.

78 c response, we find that central metabolites drastically deplete and that the intracellular AMP-to-AT

79 similar antibody responses, but these do not drastically differ from those in individuals infected wi

80 organism needs to survive in an environment drastically differ when alone or in a community.

81 uorescence quenching method, but also reveal drastically different affinity enhancing mechanisms betw

82 rimer is interacting with its chaperone at a drastically different angle and presents different faces

83 ith hyperthermal and thermal velocities with drastically different angular distributions, in agreemen

84 F4 binds LLGs and LRX cell-wall modules with drastically different binding affinities, and with disti

85 structurally these ligands alternate between drastically different binding poses but stabilize the li

86 How drastically different cell types are able to implement e

87 seudo-time analysis or require datasets with drastically different cell-types.

88 However, subsequent cycles show drastically different chemistry, with no isopropoxide li

89 e readout using a single TGT can result from drastically different combinations of force history and

90 lerae Our data suggest that ShyA assumes two drastically different conformations: a more open form th

91 These values, however, are drastically different for asialo (-1.37% acetonitrile un

92 the OAT step, a reactivity behavior that is drastically different from nonheme Fe(IV)-oxo synthetic

93 particulate organic carbon in the water was drastically different from that of bubble-bursting aeros

94 Our study reveals drastically different host cell behaviors between BEC an

95 nary divergence and among vertebrates having drastically different lifestyles such as Mus musculus, D

96 Importantly, it predicts drastically different mechanisms and kinetic pathways fo

97 Furthermore, our study reveals a drastically different motional and conformational select

98 ene (TT)-based photochromes that demonstrate drastically different optoelectronic properties upon cyc

99 stinct polymers in 9 min) from monomers with drastically different reactivity profiles.

100 ntal and theoretical results showed that the drastically different recombination lifetimes originate

101 genation/dehydrogenation processes, yielding drastically different responses for opposite light excit

102 Two drastically different scenarios are possible for the det

103 ve reactions and the DNA double helix adopts drastically different structures.

104 asts, yet their transcriptional outputs were drastically different.

105 ut not in somatically recombined CDR3 loops, drastically diminished binding and T cell responsiveness

106 This stimulatory effect was drastically diminished by a pretreatment with NaHCO(3) t

107 Single housing drastically disrupted recovery, highlighting the importa

108 d "wall-septa" microstructure of cuttlebone, drastically distinct from other natural or engineering c

109 behavior from disruptive perturbations that drastically disturb circuit output remains unclear.

110 sity lipoprotein cholesterol (HDL-C) decline drastically during sepsis, and this phenomenon is explai

111 particle size reduction from homogenization drastically enhanced (about 5-fold) bioaccessibility of

112 ese original supported Ta/Ir species exhibit drastically enhanced catalytic performances in H/D excha

113 t BCL6 deficiency in myeloid cells exhibited drastically enhanced host resistance to severe influenza

114 rts the propagation of surface plasmons with drastically enhanced intensity over multiple length scal

115 uced differentiation for 1 to 6 days, HMGECs drastically enhanced intercellular cohesion, whereas lip

116 The resulting sensor architecture could drastically expand the chemical space accessible to cont

117 jects that monitor air quality have recently drastically expanded in scale.

118 Levels drastically fell after one cycle of NAC, especially in p

119 aving more than 200 untreated cases declined drastically from 54 in 2005 to 6 in 2016.

120 constraints and immune environment, differs drastically from microenvironments of extracranial lesio

121 ttlement under climatic conditions differing drastically from that of their native range indicates ra

122 tures of interfacial reactions differ, often drastically, from those of bulk-phase reactions.

123 Single substitutions in those two clusters drastically, i.e. up to 245-fold, reduced the IC(50) for

124 r quantitative detection of biomarkers would drastically impact global health by enabling decentraliz

125 ations in surficial geology through time may drastically impact near-surface conditions.

126 fects from current treatment strategies that drastically impact quality of life.

127 However, the coronavirus-19 pandemic has drastically impacted the commercial airline industry.

128 cells showed deficient zinc transport and a drastically impaired activation program.

129 extravasation in zebrafish, and niclosamide drastically impaired metastasis in mice.

130 le the SOX protein is well characterized for drastically impairing cellular gene expression, little i

131 n of positive, but not negative, net charges drastically impedes diffusion, and that the rate is dete

132 nistration of OCA and SUMOylation inhibitors drastically impedes liver fibrosis induced by CCl(4), bi

133 of dozens of determinate lateral roots that drastically improve soil exploration and nutrient acquis

134 electrical approaches have the potential to drastically improve the quality, speed, and cost of biol

135 We propose a new approach that can drastically improve the transferability of ML potentials

136 ltradrawn UHMWPE/graphene composite films is drastically improved (>90%) by adding 2-(2H-benzontriazo

137 tion temperatures (90 vs 200 degrees C) at a drastically improved CH(3)Cl selectivity (95% vs 66% at

138 Depletion of NK cells by anti-NK1.1 Abs drastically improved cognitive function of 3xTg-AD mice.

139 87 mutations on five different proteins has drastically improved compared with previous studies, wit

140 ce (AI) tools allowed us to rapidly discover drastically improved electrosynthetic conditions, reachi

141 CD19-targeted immunotherapies have drastically improved outcomes for relapsed/refractory (r

142 gether lays out a roadmap for actuators with drastically improved performance.

143 Pressurization drastically improved phosvitin recovery in P(P) fraction

144 d abiotic stresses in hexaploid wheat can be drastically improved through wheat-alien introgression.

145 h facilitates the transport of O(2-) anions, drastically improves the reaction kinetics, and enables

146 ucture-based approach in a standalone manner drastically improves the statistical specificity, reduci

147 LC activation increased feature selectivity, drastically improving thalamic information transmission.

148 ble (mostly conjugated) polymers that differ drastically in aromatic backbone and alkyl side chain ch

149 ynthesis and find that legacy effects differ drastically in both size and length across the US depend

150 ocks of wild jackdaws (Corvus monedula) vary drastically in different contexts, leading to distinct g

151 The treatment of cancer has improved drastically in recent decades.

152 since secondary OC4 and PC varies much less drastically in space or with local primary sources.

153 wever, different regions of the world differ drastically in the availability of fine-scale data on th

154 tions, levels of both NK and T cells decline drastically in the circulation and lymphoid tissues befo

155 the lubrication properties of which diminish drastically in the presence of multivalent ions at conce

156 Blob sizes changed drastically in the region corresponding to the retinal l

157 identities of 88-98%, these proteins differ drastically in their ability to epimerize RS to RR and i

158 e of the standard stochastic models leads to drastically incorrect predictions for the switching prop

159 ionally show that our sites are projected to drastically increase in water deficit and drought freque

160 (2) accumulate at the gas-water interface to drastically increase ribozymatic activity, (3) condense

161 viral vectors for in vivo gene therapy could drastically increase safety, whilst reducing the cost of

162 idelines missed one-third of cases and would drastically increase testing volumes.

163 a anchoring and scaffolding proteins and can drastically increase the kinetics of phosphorylation.

164 of polydopamine imprinted by L-Phe biomarker drastically increase the light trapping and absorption i

165 he mitochondrial local polarity was found to drastically increase.

166 main organosulfur compound in black onions, drastically increased during the process.

167 The phosphorylation drastically increased IE2-SUMO affinity, IE2 SUMOylation

168 of soluble phenolics and lignin polymers and drastically increased PAL cellular accumulation but only

169 ne or two residues in the selectivity filter drastically increased the IC(50) value, suggesting that

170 on had some eukaryote-like complexity, which drastically increased upon mitochondrial acquisition.

171 hat the thermal isomerization rate of C6 HAT drastically increases on metal surfaces, the thermal hal

172 ceptor with a perylene diimide-based polymer drastically increases operational stability and identify

173 reby compromising scalability, which in turn drastically increases power dissipation and degrades per

174 revious research has demonstrated that ozone drastically increases the formation potential of genotox

175 d further report that N6-methylation of dATP drastically increases the MTH1 activity.

176 amma-TuRC-mediated nucleation, while XMAP215 drastically increases the nucleation efficiency by stren

177 However, it also drastically increases the technological complexity to sy

178 te an assembly strategy for DNA storage that drastically increases the throughput of nanopore sequenc

179 Reduced glutathione drastically increases the warfarin sensitivity of a VKOR

180 rapidly bundle into an elongated aggregate, drastically increasing drag that consequently slows drop

181 Drastically increasing the buffer capacity did not stand

182 Context can drastically influence responses to environmental stimuli

183 a single amino acid mutation on the peptides drastically influenced their ability to interact with co

184 d of MV(2+) photoreduction, while the doping drastically influences this quantum yield of MV(2+) radi

185 learn to use auditory or visual reward cues, drastically influencing their performance within a simpl

186 the presence of Ec in polymicrobial samples drastically inhibited phenazine production rates in both

187 nce, the molecular nature of NOM has changed drastically: it became much more oxidized and enriched w

188 Visual speech produced drastically larger enhancements during spectral degradat

189 ce on single-copy genes for this purpose has drastically limited the amount of data that can be used.

190 t the killing efficacy of radiotherapy while drastically limiting the received dose and reducing the

191 strain has been through heteroepitaxy, which drastically limits the possible material combinations an

192 o demonstrated that TMC6 and TMC8 levels are drastically lower and the proteins are less active in re

193 Also, children displayed drastically lower coherence at 4-8 Hz in all SNR conditi

194 Yeast protein concentrate showed drastically lower impacts in all categories compared to

195 ) of fusion proteins such as SNARE molecules drastically lower the free energy of both the stalk barr

196 ndreds of candidate domestication genes with drastically lowered genomic diversity in the cultivated

197 GPCR-associated neurological disorders show drastically lowered levels of PUFAs.

198 tion myocardial infarction (STEMI) decreased drastically, mainly through reduction in inhospital mort

199 onality of isomeric carbohydrates may differ drastically, making their identifications indispensable

200 The cecal microbiota composition was drastically modified in the KHK-F in association with an

201 d outline a paradigm in which chemokines can drastically modulate innate immune receptors without bei

202 assical alkyne complexes of Pt(II) and their drastically more reactive Au(III) congeners.

203 reme pore pressures within overlying strata, drastically narrowed the range of safe operational boreh

204 lies on a variety of services that have been drastically occupied to treat patients affected by COVID

205 ncy of perovskite solar cells (PSCs) depends drastically on the charge-carrier dynamics.

206 trajectories for global habitat ranges vary drastically, providing important quantitative evidence f

207 The fluorescence intensity of ADD probe was drastically quenched in presence of AA, and shown excell

208 ological processes of health and disease has drastically raised the demand for detailed structural ch

209 other clusters until 2017, when it increased drastically, reaching 85% by the end of the study period

210 through changes at Ser(130) and such changes drastically reduce cephalosporin but not penicillin hydr

211 burn studies establish that these materials drastically reduce ignition probability before and after

212 This is expected to drastically reduce monitoring costs for OST-based sanita

213 tle or a ball mill; microwave activation can drastically reduce reaction times; ultrasonic activation

214 ease burden, and 2) "suppression," aiming to drastically reduce SARS-CoV-2 transmission rates and hal

215 based study, we found that a colonoscopy can drastically reduce the absolute risk of CRC and that the

216 These guidelines drastically reduce the indications for prophylaxis again

217 During these times of the year birds drastically reduce their amount of sleep, yet curiously

218 at a price point below US$400, which will be drastically reduced as IR (thermal) arrays are integrate

219 Vision is drastically reduced at the time of saccades.

220 ive to visible wavelengths, primarily due to drastically reduced autofluorescence.

221 RetGC activity in rd3/rd3 retinas was drastically reduced but stimulated by the endogenous GCA

222 oenzyme A desaturase 1, and perilipin 2) was drastically reduced by EGFR inhibition.

223 We show here that this resistance can be drastically reduced by preventing direct contact with th

224 ) gO (GT1a) [referred to here as ADgO(GT1a)] drastically reduced cell-free infectivity of both strain

225 the CH(4) storage/delivery process could be drastically reduced compared to the conventional CH(4)-a

226 QFP logic, dynamic energy dissipation can be drastically reduced due to the adiabatic switching opera

227 Individuals carrying missense variants with drastically reduced FANCD2 monoubiquitination in biochem

228 auses pollen tube growth defects, leading to drastically reduced fertility.

229 es detected by LC-HRMS in the raw sample was drastically reduced from 1500 to 9, and among them, two

230 to wild-type (wt) MEFs, indicating that the drastically reduced GTP turnover restricts oligomer disa

231 uitinated H2BK120 in vitro, and loss of UBR7 drastically reduced H2BK120Ub genome-wide binding sites

232 n throughout the experiment, while both were drastically reduced in allografts.

233 of mastoparan-L toward mammalian cells were drastically reduced in both variants.

234 al phenotypes in visceral adipose tissue are drastically reduced in cavefish.

235 candidate, but its functional expression is drastically reduced in cells that express the most commo

236 Indeed, SPECC1L expression is drastically reduced in Irf6 mutant palatal shelves.

237 dels, we demonstrate that melanoma growth is drastically reduced in mice lacking c-Rel, but not p65,

238 As such, the expected NPP is drastically reduced in our updated model relative to pre

239 he 2 master regulators sigma B and RpiRc was drastically reduced in the Deltatkt mutant during host c

240 , the prevalence of canine MPS IIIB has been drastically reduced in the Schipperke population worldwi

241 tiation, an inhibitory antibody against Ecad drastically reduced intercellular cohesion and blocked l

242 pletion of gamma1, but not gamma2 or gamma3, drastically reduced metformin activation of AMPK.

243 TPL2 signalling and IL-10 production showed drastically reduced pathogenesis.

244 nts in which TF is not palmitoylated display drastically reduced plasma membrane localization, which

245 3-monooxygenase that converts KYN to 3HKYN, drastically reduced RQ but not Q levels.

246 s are enriched for in-frame insertions, have drastically reduced sequence bias as well as near-comple

247 n 2 and 5 months post-status epilepticus and drastically reduced the frequency of spontaneous seizure

248 cyte metabolic and inflammatory activity and drastically reduced the number of circulating monocytes.

249 utralization by specific antibodies or traps drastically reduced the RGC survival.

250 ibody (NAb) responses, whereas ablating CX3C drastically reduced the RSV NAb response.

251 This drastically reduced their calf losses by cheetahs becaus

252 In addition, the analysis time was drastically reduced to about 30 min, as opposed to hours

253 This setup provided a drastically reduced transfer distance between OPI and ES

254 d in the monomeric form, is unexpectedly and drastically reduced upon being covalently attached to th

255 ile expression of catalytically inactive APX drastically reduced virulence.

256 cles and directly isolated mitochondria were drastically reduced when they were derived from monocyti

257 OC fate is that under some conditions, OH is drastically reduced while non-tropospheric/undesired VOC

258 The Taxol yield of A. terreus was drastically reduced with the fungal subculturing.

259 lysaccharide-induced TNFalpha expression was drastically reduced, but MK2-deficient cells became high

260 ing which neural progenitor proliferation is drastically reduced, but resumes when food becomes avail

261 cardial beta(1)AR expression in USP20-KO was drastically reduced, whereas beta(2)AR expression was ma

262 ng) because the extreme physical environment drastically reduces biodiversity and ecological complexi

263 ificial corona made of human plasma proteins drastically reduces capture by circulating leukocytes in

264 ce versa, pharmacological inhibition of Acc1 drastically reduces cell survival and results in the acc

265 nstead that acute silencing of CA3 terminals drastically reduces place field responses for many CA1 n

266 c interconversion into other monosaccharides drastically reduces such specificity in the living cell.

267 nts, negatively impacts patient outcomes and drastically reduces survivor's quality of life (QOL).

268 ation of nanotopography-induced actin fibers drastically reduces the amount of stress fibers and matu

269 In virus-infected cells, the Us11 protein drastically reduces the formation of autophagosomes medi

270 placental lactogen in beta-cells of Ak mice drastically reduces the severe hyperglycemia, diabetes i

271 controllable shape morphing potential, while drastically reducing the required fabrication times for

272 By drastically reducing the vast parameter space of nonequi

273 absent in common E. coli expression strains, drastically reshapes the mutational landscape of the met

274 ropagation, and tunneling effects leading to drastically resistance change play an important role.

275 el in urine ranges from 7 to 20 mg/dL, which drastically rises under patho-physiological conditions t

276 aused nonresponder BD hippocampal neurons to drastically shift their excitability with small changes

277 /- 2.5%) glia (GFAP positive), PPA treatment drastically shifted differentiation to 80% GFAP cells (p

278 In addition to drastically shortening the reaction times, the use of mi

279 ing the human tongue as a porous material to drastically simplify computational approaches and that p

280 of the data in different areas of science is drastically slowed and hindered by a lack of standards a

281 Beyond these lengths, folding is drastically slowed by nonnative interactions involving C

282 to circadian clock entrainment operates on a drastically slower timescale compared with fast, norpA-d

283 w that its symbiont, Ca R. santandreae has a drastically smaller genome (1.34 Mb) than the symbiont's

284 ddition, the ferrihydrite fraction decreases drastically, suggesting the preferential dissolution and

285 hotoreceptors, whose photoresponses remained drastically suppressed compared with the WT.

286 1 did not affect primary tumor formation, it drastically suppressed lung metastasis.

287 The presence of only 0.1 mg/L SRHA drastically suppresses the heteroaggregation propensity

288 obust to sequence boundary noise and reduces drastically the computational cost allowing for large da

289 HS prior to CA storage reduces more drastically the ripening heterogeneity in middle season

290 e use of these new tools was shown to reduce drastically the selection of escape mutants.

291 maximum value in the relaxed state and drops drastically under any deformation, indicating that the c

292 vidence demonstrating that this approach can drastically underestimate error rates for proteome-wide

293 that the FDRs in top-down proteomics can be drastically underestimated.

294 single-layer level show that the sheets are drastically weakened as the in-plane porosity increases.

295 ificantly enhanced if some of the sheets are drastically weakened by introducing in-plane porosity.

296 icity, whereas reducing Tip60 HAT expression drastically weakened rhythmicity.

297 at simultaneous mutation of these histidines drastically weakens the cis interaction and enhances spo

298 d that chromatin occupancy of PRC2 increases drastically when it is forced to form PRC2.1.

299 s per hour, and stridulation rates increased drastically with increasing larval abundance.

300 d demonstrates that alignment times increase drastically with increasing rigidity of the RBC membrane