ライフサイエンスコーパス: drawback

1 hability still represents a major commercial drawback.

2 ct periodicity requirement could represent a drawback.

3 ons, a too high MS/MS readability could be a drawback.

4 d analysis parameters, which remains a major drawback.

5 ularly for in cellulo applications) remain a drawback.

6 centre in silicon carbide is immune to both drawbacks.

7 pects of cell size, but each has significant drawbacks.

8 ome older studies suffer from methodological drawbacks.

9 s which lack spatial resolution, among other drawbacks.

10 aches that address tissue heterogeneity have drawbacks.

11 s is one such method that suffers from these drawbacks.

12 vivo instability of CFZ are considered major drawbacks.

13 and was therefore modified to overcome these drawbacks.

14 a step forward in this process but has some drawbacks.

15 uires fluorescent labeling which has several drawbacks.

16 t clears the major previously mentioned GNPS drawbacks.

17 ntial advantages as well as their respective drawbacks.

18 ule management, outlining their benefits and drawbacks.

19 ologous nerve graft (autograft), has several drawbacks.

20 refined cereals and limitation of their main drawbacks.

21 d toxicological studies reveal no observable drawbacks.

22 propylbenzoates, largely overcomes the above drawbacks.

23 These approaches have two notable drawbacks.

24 ntional DMN fabrication methods have several drawbacks.

25 examples reported in the literature present drawbacks.

26 , including analysis of their advantages and drawbacks.

27 lic health emergencies, including some major drawbacks.

28 demonstrate good potential to overcome these drawbacks.

29 studies are underway to address some of the drawbacks.

30 sting network alignment-free approaches have drawbacks: 1) They rely on naive measures of network top

31 To overcome these drawbacks, a chemoenzymatic method has been developed ut

32 Because this approach has important drawbacks, an alternative procedure is proposed by apply

33 dministration is associated with a number of drawbacks and advanced delivery platforms could provide

34 the currently available SHIVs have distinct drawbacks and are unable to fully reflect the features c

35 The potential drawbacks and barriers to combination drug treatment as

36 oparticle-based PET imaging has its inherent drawbacks and can possibly lead to erroneous imaging res

37 Finally, the drawbacks and limitations of LDG based electrochemical b

38 d for this purpose, many are associated with drawbacks and limitations that justify the development o

39 A series of drawbacks and perspectives are presented for the most co

40 The main drawbacks and superiorities associated with each array a

41 benefit from the lessons learned from these drawbacks and the current developments in primate commun

42 h nano-DDS may be useful in overcoming these drawbacks and thereby reveal the full potential of bacte

43 ortant fields, with their own advantages and drawbacks, and provide our perspective about the issues

44 ortant fields, with their own advantages and drawbacks, and provide our perspective about the issues

45 uromodulin in urine has several preanalytic drawbacks, and sensitive assays for the detection of uro

46 currently used in cheesemaking have various drawbacks, and there is a continual need to find new coa

47 zymes, aptamers, MIPs); their advantages and drawbacks are discussed in this review.

48 These drawbacks are gradually being overcome by improving our

49 ciples, mechanisms of action, advantages and drawbacks are presented to provide useful information fo

50 ALPPS offers improved resectability, but drawbacks are regularly pointed out regarding safety and

51 Drawbacks are that the labeling process is labor intensi

52 Major drawbacks are, however, an inherently low electrical con

53 However, DP has a known drawback as it does not consider the correlation between

54 s and aims at identifying the advantages and drawbacks as well as guiding future works, research dire

55 This method has drawbacks, as it cannot detect pathogen-sized contaminan

56 inding partners, however, comes with certain drawbacks, as it relies on identifying binding events by

57 The sensors/biosensors overcome these drawbacks, as these are fast, easy, cost effective and h

58 The biosensing methods overcome these drawbacks, as these are simple, fast, specific and highl

59 A major drawback associated with the use of chlorine as disinfec

60 otential "green alternative" to overcome the drawbacks associated with conventional chemical methods.

61 icosteroid dexamethasone despite significant drawbacks associated with its use.

62 ethodologies and nanozymes to circumvent the drawbacks associated with natural enzymes.

63 optimizations, as well as opportunities and drawbacks associated with the development of quinolones

64 These safe and practical salts avoid many drawbacks associated with traditional HX sources includi

65 al alloy is an alternative that detours this drawback, but the fundamental understanding of charge tr

66 one electron/Na) were identified as possible drawbacks, but strategies to address these issues were d

67 Next-generation sequencing overcomes this drawback by untargeted shotgun sequencing of whole metag

68 The graph-guided methods overcome this drawback by using the sample correlation to define the c

69 Here, we identify a pathway around these drawbacks by showing that an engineered quantum well can

70 These drawbacks can be circumvented by CAR-T cells targeting t

71 The impact of these drawbacks can be partly compensated by manual work that

72 These drawbacks cause poor rate capability and fast capacity d

73 hemical biosensors to overcome the enzymatic drawbacks, combining low cost scalable materials with su

74 This drawback could be avoided by selecting mixed cover crops

75 This drawback could be overcome by complexation in cyclodextr

76 We anticipated that these drawbacks could be overturned by judicious postsynthetic

77 is provided, highlighting the advantages and drawbacks depending on the application.

78 c generation from alkyl halides has a severe drawback due to the employment of toxic tin hydrides to

79 One of the drawbacks during second-generation biofuel production fr

80 insolubility in water may constitute a major drawback, especially during the investigation of biochem

81 and surgical complications represent a major drawback for its use.

82 , polymorphism has usually been considered a drawback for technological applications.

83 PS), as a side product appears to be a major drawback for the production of certain biomolecules that

84 immobility of fMRI constitute a challenging drawback for the scalability (accessibility and cost-eff

85 namic crystals, while they also reveal their drawbacks for actual application as actuators.

86 rast to agar environments that pose specific drawbacks for characterization of C. elegans burrowing a

87 selected vibrational modes, leads to serious drawbacks for interrogation of the trapped phonons, incl

88 eceptor (H(2)R) radioligands possess several drawbacks, for example, high non-specificity, insurmount

89 ) and proteins/enzymes has both benefits and drawbacks: for example, it is put to good use in electro

90 nd actuating performance, and some important drawbacks have diverted the interest of engineers from t

91 Conventional technologies have several drawbacks (i.e., cross-infection risk, filtration effici

92 zation as an example, there are three common drawbacks, i.e., obsolete datasets without updating labe

93 This approach has several important drawbacks: (i) ChIP interpretation necessitates the assu

94 een developed, they often have the following drawbacks: (i) lack of interpretability or interpreting

95 t deactivation by coke deposition is a major drawback in industrial processes.

96 ponse to biological products (BP) is a major drawback in the treatment of patients.

97 To overcome intrinsic drawbacks in specificity, sensitivity, and throughput of

98 , all these tools have their limitations and drawbacks in terms of their effectiveness, user-friendli

99 Potential methods for managing this drawback include active comparison groups, within-indivi

100 en volitional breathing is insufficient, but drawbacks include muscle atrophy, alveolar damage, and r

101 Potential drawbacks include the requirement for 2 vaccine doses se

102 Nevertheless, SpCas9 has some drawbacks including a relatively large size and restrict

103 chieved by current antiretroviral therapies, drawbacks including drug resistance and the failure to e

104 ighly relevant, yet still plagued by diverse drawbacks including erroneous target amplification, and

105 gold standard for pH measurements but suffer drawbacks including frequent recalibration, wet storage

106 quid amine absorption technology has several drawbacks including hazardous byproducts and a high-ener

107 past 2 decades have generally suffered some drawbacks including lack of translatability of target in

108 mmonly used Pt-based catalysts still exhibit drawbacks including limited catalytic activity, high ove

109 sed nNOS inhibitors, but these compounds had drawbacks including off-target promiscuity, low activity

110 tting algorithms; however, these suffer from drawbacks including the local minimum problem and substa

111 Nevertheless, it has some drawbacks, including a relatively big size, imperfect sp

112 er, the first-generation DES had substantial drawbacks, including delayed healing, local hypersensiti

113 ions, these inorganic magnets suffer several drawbacks, including energetically expensive fabrication

114 S cathode has been plagued by its intrinsic drawbacks, including high activation potentials, poor ra

115 g (ChIP-seq), are widely used but have their drawbacks, including high false-positive rates and limit

116 ble statistical foundations, this method has drawbacks, including its hitherto unknown intrinsic lack

117 d tool, the CRISPR/Cas9 system can have some drawbacks, including off-target mutations and mosaicism,

118 is 35 kDa protein is associated with several drawbacks, including temperature sensitivity, Ca(2+) dep

119 In this perspective, advantages as well as drawbacks influencing the use of OH groups in medicinal

120 ophrenia (SZ) diagnosis, which overcomes the drawbacks inherent with the subjective diagnostic method

121 r polymer acceptors to date, eradicating the drawbacks inherited in N2200 and other high-performance

122 ments, technological issues, advantages, and drawbacks involved in natural gas storage in these two c

123 , its well-known and incompletely understood drawback is its low tolerance to chlorine, the most effi

124 A drawback is that the large size of nanoparticles restric

125 lects SASA and hydrogen bonding, whereas one drawback is the labeling is reversible.

126 However, its biggest drawback is the limit in printing resolution.

127 The only significant drawback is the need for antireflux surgery in the first

128 However, a major drawback is the need for invasive implantation of optica

129 1/PD-L1 inhibitors that could overcome these drawbacks is slow because of the incomplete structural i

130 But the drawback lies in the fact that these methods require spe

131 itive and selective, these methods have some drawbacks like time-consuming, requirement of sample pre

132 beling methods described so far have several drawbacks, like hydrolytic instability, slow reaction ki

133 on and detection still has several technical drawbacks, mainly related with problems of sensitivity a

134 Though these methods have some recognized drawbacks, many have already demonstrated improved sensi

135 versatility, supervised machine learning has drawbacks, most notably its dependence on a priori knowl

136 es, and magnetic resonance imaging have some drawbacks, mostly related to their invasive character, h

137 Current repellents have drawbacks, necessitating development of more effective a

138 d standard for OSCC diagnosis; however, some drawbacks need to be overcome.

139 To resolve these critical drawbacks, numerous approaches have focused on developin

140 in decentralized water treatment, one major drawback of adsorbents is their limited recyclability du

141 ndex to exploit rapid phase changes with the drawback of also modulating amplitude.

142 A drawback of AR however is related to uncertainty regardi

143 The unique gating mechanism overcomes the drawback of charge screening seen in traditional FET bas

144 One important drawback of current genetic studies is the limited knowl

145 racterization; however, they suffer from the drawback of diffraction-limited spatial resolution.

146 tool to increase assay sensitivity with the drawback of increasing its variability by approximately

147 ontact patterning and thus overcome the main drawback of insulating passivation layers.

148 To address a key drawback of Laurdan linked to its rapid internalization

149 A drawback of MG11 is its fast degradation by proteases, l

150 However a potential drawback of NS1 as a vaccine is that anti-DENV NS1 Abs c

151 A general drawback of previous studies is an insufficient density

152 They have the drawback of requiring reasonably good leaving groups for

153 This approach has the drawback of requiring very high energy, up to the multi-

154 Our results thus show that the classical drawback of run-and-tumble navigation-wasteful runs in t

155 One major drawback of SFX studies with XFELs is the consumption of

156 nsitivities for DA, but display the negative drawback of slow adsorption and electron transfer kineti

157 The drawback of such an approach is that there is a limited

158 However, a common drawback of such methods is that the decomposition primi

159 iting valve durability, remains an important drawback of surgical and transcatheter bioprostheses.

160 Our findings also indicate the drawback of the distorted crystal field picture in expla

161 , focusing on genomic datasets, we show this drawback of the DP and we propose techniques to mitigate

162 f short-lived radical species is an inherent drawback of the heterogeneous system.

163 A drawback of the proposed approach is that the number of

164 A major drawback of these materials is, however, the low mechani

165 A drawback of this approach, however, is that once synthes

166 A drawback of this approach, to the synthesis of polycycli

167 ments to test different scenarios is a major drawback of this approach.

168 However, the main drawback of this material is the low stability and high

169 A common drawback of this modality is a resultant increase in lef

170 A significant drawback of using Miscanthus in an energy application is

171 We highlight the many drawbacks of a commitment to compositional representatio

172 dy of a nationwide WM-system, advantages and drawbacks of a mass balance approach are discussed.

173 reasonable clearance, thus overcoming major drawbacks of AuNPs.

174 The systems introduced here avoid drawbacks of both types of technologies, by combining hi

175 nojunction (s-BCN) overcomes a few intrinsic drawbacks of carbon nitride film (severe bulk charge rec

176 s offer a promising solution to overcome the drawbacks of chemical reduction routes.

177 novel analysis allows us to correct certain drawbacks of Clar's analysis with respect to polycyclic

178 ction and highlighted potential benefits and drawbacks of combining ATRA with DARA in patients with M

179 Drawbacks of conditional gene deletion in mice include t

180 let activation and clogging, are significant drawbacks of conventional 'dead end' filtration.

181 n serve this purpose, overcoming some of the drawbacks of conventional lab-based techniques.

182 peroxymonosulfate (PMS) activation to avoid drawbacks of conventional transition metal-containing ca

183 e remains a significant challenge due to the drawbacks of current adsorbents such as low uptake capac

184 tential of 3D bioprinting, there are several drawbacks of current bioinks and printing methodologies

185 sed vaccine with D antigenicity, without the drawbacks of current vaccines, will be a major step towa

186 The drawbacks of currently applied treatment include high sy

187 r effect (NOE) enhancements are the two main drawbacks of decoupling schemes.

188 olymerization is one of the most significant drawbacks of dental resin composites, since it is relate

189 cessfully, while others were resigned to the drawbacks of dialysis.

190 We discuss the strengths and drawbacks of different gene-perturbation approaches, and

191 are measureable through the skin, obviating drawbacks of dual sugar absorption tests.

192 We highlight the benefits and potential drawbacks of each ligand class and propose directions in

193 We critically analyze the benefits and drawbacks of each method.

194 the technology status and the advantages and drawbacks of each route in terms of feedstock, reaction

195 the characteristics and major advantages and drawbacks of each system and identified the most critica

196 analytical performances, the advantages and drawbacks of each type of biosensor are highlighted, dis

197 One of the main drawbacks of ELISA is the involvement of multiple washin

198 These drawbacks of existing gene based methods motivated us to

199 scular disease rate coupled with significant drawbacks of existing therapies emphasise the necessity

200 work, we show that ASM eliminates the major drawbacks of FSM including complex elution solvent profi

201 The drawbacks of global stochastic optimization methods are:

202 Finally, we consider the opportunities and drawbacks of intensively interrogating antibodies isolat

203 ia the TM S bond, effectively addressing the drawbacks of Li(2) S cathodes.

204 mber of cell-cycle regulation biomarkers and drawbacks of limited human tissue samples.

205 ls reported so far still suffer from several drawbacks of low efficiency or poor stability, thus rest

206 es of the wealth of nations, the benefits or drawbacks of markets and international trade, the effect

207 One of the major drawbacks of microfluidic PCR is bubble generation and r

208 o mixed-metal MOFs do not escape the typical drawbacks of MOFs, such as low stability in moisture and

209 Avoiding the drawbacks of most conventional BAM instruments, this con

210 me, however, we would like to reflect on the drawbacks of MRI screening that affect its applicability

211 Drawbacks of observational pharmacoepidemiological studi

212 In order to bypass some drawbacks of optical fluorescent reporting systems, we h

213 tices of TDN, which could not only avoid the drawbacks of poor controllability and biocompatibility f

214 cting human biosignals, but have significant drawbacks of power consumption issues that limit sustain

215 Three major drawbacks of previous C(sp(3) )-H olefination protocols,

216 sing a resonator and evaluate advantages and drawbacks of resonating and non-resonating solutions.

217 lly wearable tear-sensing platform addresses drawbacks of sensor systems involving direct contact wit

218 o confirmed that it can easily overcome many drawbacks of similar liquid-liquid-liquid approaches.

219 sed on such prior knowledge, we overcome the drawbacks of snap-shot data by considering the possible

220 measurement strategy aims at fixing the main drawbacks of standard quantum measurements by achieving

221 yloid plaques have been performed due to the drawbacks of the commonly used techniques such as matrix

222 Moreover, the advantages and drawbacks of the different types of transducers are disc

223 microRNAs (miRNAs) in serum can overcome the drawbacks of the existing diagnostic methods.

224 A detailed comparison of the merits and drawbacks of the experimental and computational techniqu

225 errate (K(2)FeO(4)) circumvents the inherent drawbacks of the instability of ferrate under humid cond

226 ession in Arabidopsis that overcomes several drawbacks of the legacy systems.

227 ualization method addresses some of the main drawbacks of the original methodology and might bring th

228 ference between ions remains one of the main drawbacks of the technique.

229 tition of new compounds, which overcomes the drawbacks of the traditional shake-flask method and pres

230 We discuss the advantages and drawbacks of the two major strategies-purified and extra

231 rganoids and the challenges, advantages, and drawbacks of the use of organoids for these studies.

232 ding a general picture of the advantages and drawbacks of these new solvents as well as the main rese

233 been performed, it evidencing advantages and drawbacks of these.

234 The main drawbacks of this approach are the fact that there is no

235 an judgment, and we discuss the benefits and drawbacks of this approach.

236 Understanding the current drawbacks of this model is essential for the correct dat

237 The main drawbacks of today's state-of-the-art lithium-air (Li-ai

238 SSM circumvents the drawbacks of transposon-mediated transgenesis, where ran

239 fibrillate ventricular arrhythmias, avoiding drawbacks of transvenous leads.

240 To overcome the drawbacks of unrefined magnetite we used an electrochemi

241 lving any c-plane facets, allowing the major drawbacks of utilising c-plane GaN for the growth of III

242 experiences, and discuss the advantages and drawbacks of varying the beta-emitter in PSMA-targeting

243 ree ensemble methods that overcomes the main drawbacks of VQSR and HF.

244 An approach to overcome drawbacks of well-established transducer materials for a

245 of fluorescent labels, however with a strong drawback: polarized fluorescence imaging is indeed spati

246 The challenges and drawbacks presented by this technology are also discusse

247 To resolve drawbacks related to cysteine conjugation, we have inven

248 ostic methods of FMDV have demonstrated many drawbacks related to sensitivity, specificity, and cross

249 t and comparison of large data sets, several drawbacks related to the MS-Cluster tool routinely used

250 However, ELISA has clear drawbacks related to the use of relatively unstable anti

251 stinal tract has been faced with a number of drawbacks related to their prolonged use.

252 However, their main drawback relies on the poor reliability derived from the

253 To overcome these drawbacks, research efforts are devoted toward the devel

254 To address this drawback, single-molecule methods offer a way to access

255 These membranes, however, cause many drawbacks such as a high pumping cost and a need for per

256 ructure optical switches suffer from serious drawbacks such as high drive voltage, limited operation

257 In addition, traditional animal models have drawbacks such as high-cost, long periods and physiologi

258 de side reactions/corrosions, but introduces drawbacks such as intergranular cracking.

259 This technique has some fundamental drawbacks such as low sample throughput and a lack of di

260 However, bacteriocins present a few drawbacks, such as sensitivity to proteases, immunogenic

261 emselves are complex and have many potential drawbacks, such as serious and rarely fatal infections,

262 ulty in dealing with mixtures of analytes, a drawback that severely limits the applications of this s

263 ntibodies can be associated with significant drawbacks that are often overlooked including lot-to-lot

264 tional pharmacotherapy suffers from multiple drawbacks that hamper patient treatment, such as the bui

265 he need for sample dilution are still common drawbacks that hinder their use in routine diagnosis.

266 er to offer a clear view of the benefits and drawbacks that HPSDS can provide over what we could cons

267 of creatinine, as well as an overview of the drawbacks that impede their definitive point-of-care est

268 ation, and poor pharmacokinetics are current drawbacks that limit performance and the scope of possib

269 in self-assembly has several well-recognized drawbacks that limit performance in certain technical ar

270 of these techniques suffers from fundamental drawbacks that limit their application.

271 However, both approaches suffer from drawbacks that limit their use.

272 available pain medications like opioids have drawbacks that make long-term use untenable.

273 plet microfluidic platforms have fundamental drawbacks that undermine their utility toward applicatio

274 As a drawback, the decreased conductivity can lead to drastic

275 To overcome this drawback, the introduction of luminescent markers was pr

276 Despite the drawbacks, the proposed approach is generally applicable

277 However, due to the many inherent drawbacks, there is a search for new chemotherapeutic dr

278 One important drawback to current fuel-cell technology is the high con

279 One drawback to performing targeted analysis on ion trapping

280 One drawback to previous studies has been the inability to c

281 A drawback to this approach is that substitution at more t

282 While there are numerous drawbacks to coil embolization, physician expertise, ava

283 able information highlighting advantages and drawbacks.To what extent can we preserve the noble purpo

284 This drawback ultimately resulted in the development of sever

285 ctive solution is suggested to mitigate such drawbacks using strategically designed surface-2D/bulk-3

286 These drawbacks warrant the development of a new generation of

287 To overcome this drawback, we designed an optimized dual layer ITO MEA wi

288 To circumvent this drawback, we generated an eye-specific Dcc mutant.

289 To overcome these drawbacks, we present a holographic Maxwellian near-eye

290 To circumvent these drawbacks, we present the first example of a DFT guided

291 To overcome these drawbacks, we proposed to filter decay curves instead of

292 To address these drawbacks, we provide an extension of the widely used op

293 Some drawbacks were identified with the INLA-SPDE database, i

294 however, its high hydrophobicity is a major drawback, which cause fouling.

295 e findings suggest no significant benefit or drawback with the use of either FDBA or SDBA when compar

296 Each regimen has drawbacks with regard to maternal or fetal risk.

297 All approaches have significant drawbacks with respect to stability and efficacy, but th

298 Potential drawbacks with such peptides include poor pharmacodynami

299 This drawback would be overcome if cellular ablation could be

300 A possible solution to this drawback would be to radically decrease detection thresh