ライフサイエンスコーパス: driver

1 y from electric technology vehicles (1.7% of drivers).

2 somatic, rather than neutral versus disease driver.

3 ibutaries; instead, salinity was the primary driver.

4 ing complexity as a result of the extinction drivers.

5 1-2016 and identified the potential dominant drivers.

6 ineering of missense mutations in key cancer drivers.

7 al, socio-economic and societal contexts and drivers.

8 een 1960s and 1990s) and identifies the main drivers.

9 sts and 110 low-path AIVs with 32 species as drivers.

10 locations and gene fusions, are often cancer drivers.

11 ions and 0-6% of cells had two or even three drivers.

12 ent motor vehicle crash involvement by older drivers.

13 prevalence and understanding the associated drivers.

14 otential endowed by accumulation of multiple drivers.

15 ipping point in barrier response to external drivers.

16 istent factors and identified the underlying drivers.

17 Our analyses confirm previously reported drivers(6,7), raise doubts about others and identify nov

18 are not aligned with this central oncogenic driver activate divergent pathways and subvert transform

19 pe hosts compared to those with an inherited driver allele.

20 Identifying the cancer-driver alterations amongst the vast swathes of "passenge

21 V non-small-cell lung cancer (NSCLC) without driver alterations.

22 g multiplatform analysis of commonly mutated driver and nonpassenger genes.

23 shared control of a primary and a secondary driver and to indicate how blame should be allocated.

24 cs arise from the interplay of environmental drivers and disturbances with the demographic processes

25 The climatic drivers and genomic basis of seed mass variation remain

26 ypes of CT projections have been recognized: drivers and modulators.

27 Yet, the drivers and patterns of microbiota imbalance (dysbiosis)

28 is behavioural variation, describing the key drivers and providing a tool to account for biases in mo

29 ularly guided treatments targeting oncogenic drivers and the DNA damage response and repair pathway w

30 e oceanic background state, local and remote drivers and the ocean productivity response from past ev

31 STK19 was proposed to be a cancer driver, and recent work by Yin et al. (2019) in Cell sug

32 ynamic cellular programs and their molecular drivers, and apply it to HIV infection.

33 However, its antiquity, drivers, and development remain unclear, as they do for

34 romise, but current technologies to identify drivers are limited by spatial resolution.

35 Fortunately, many of these AF drivers are potentially reversible, and emerging evidenc

36 d projected physical variables, (b) physical drivers are statistically significant for Pacific cod an

37 with isolated hazards, the multiple hazards/drivers associated with CEs can lead to higher economic

38 tion dynamics, which makes detecting climate drivers at the population level challenging.

39 ical carbon pump have been implicated as the drivers behind the rise in atmospheric CO(2) across the

40 e complex models (i.e., considering multiple drivers), beyond simple vicariance of Caribbean and Paci

41 edator exclusion experiment to elucidate the drivers, both geomorphic and biotic, controlling the est

42 rves related to their sensitivity to various drivers by carrying out a global scale assessment (using

43 sults show how the relative strengths of ITV drivers change over time.

44 transition between limitations accurately as drivers change.

45 a demonstrate an approach to identify cancer-driver coregulators in cancer, and that PGC1alpha expres

46 motif sequences of our previously nominated driver DAPs.

47 am frequency spectra may accurately automate driver detection by MEM and add some objectivity to the

48 mpacts of abiotic, biotic, and anthropogenic drivers differ, accounting for their direct effects and

49 significance levels from multiple methods of driver discovery that overcomes the limitations of indiv

50 ructural variants, we present two methods of driver discovery, and identify regions that are signific

51 Other drivers (e.g. human demography and migration in tropical

52 mutation is well established as an oncogenic driver event in cancer and its durable and efficacious i

53 tic events that cooperate with known somatic driver events are poorly understood.

54 We demonstrate that the order of driver events in colorectal cancer is determined primari

55 macroevolutionary processes and alternative drivers explaining this pattern remain elusive.

56 post-XCI embryonic cells using the Meox2-Cre driver, female pups exhibit no morbidity or mortality de

57 sor, an inertial measurement unit and an LED driver for an external optogenetic probe.

58 the photoautotroph community is an important driver for CH(4) production and its highly dynamic accum

59 esistant Enterococcus faecium (VREfm) is the driver for E. faecium carriage in hospitalized patients,

60 es indicate that Pten-NOLC1 gene fusion is a driver for human cancers.

61 ng protein HuR/ELAVL1 as a central oncogenic driver for malignant peripheral nerve sheath tumors (MPN

62 One central driver for relapse events is the negative aversive sympt

63 rigin of the L2/L3/L4 Mtb lineages was a key driver for their global epidemic spread and outstanding

64 ctive behaviour can be an emergent selective driver for undifferentiated multicellularity.

65 As more data is generated, oncogenic drivers for specific cancer types are discovered along w

66 and workforce issues in primary care are key drivers for the growing international trend to expand nu

67 investigation is warranted to understand the drivers for this, and their potential to contribute towa

68 a) from high and low levels of an identified driver from demographic studies of terrestrial plants.

69 To discover driver fusions beyond canonical exon-to-exon chimeric tr

70 Driver gene alterations have been comprehensively charte

71 We propose a novel cancer driver gene detection method, QuaDMutNetEx.

72 s in higher expression of FLT3, an important driver gene in acute leukemias.

73 Recent studies show that aneuploidy and driver gene mutations precede cancer diagnosis by many y

74 ty that foster tumorigenesis rather than new driver gene mutations, including significant pancreatic

75 ted by CAR-T cells targeting tumour-specific driver gene mutations, such as the four-nucleotide dupli

76 ring storage revealed genotype-specific main driver genes and pathways characterizing storability.

77 s (genomic amplification) pinpoint oncogenic driver genes and therapeutic targets in cancer genomes.

78 Surprisingly, CLL driver genes are characterized by specific local wiring

79 Additionally, we confirm critical cancer driver genes by analysing cell-line datasets.

80 Whether mutations in cancer driver genes directly affect cancer immune phenotype and

81 hylation, and point mutations in lung cancer driver genes in 292 tumor samples from 84 patients with

82 esponding cell lines establishes the role of driver genes in diverse contexts and enables mechanistic

83 Current approaches either identify driver genes on the basis of mutational recurrence or ap

84 11,873 tumor-normal pairs and identified 460 driver genes that clustered into 21 cancer-related pathw

85 ens, predicted neoepitopes, and mutations of driver genes were concatenated into a single mRNA constr

86 have identified thousands of putative cancer driver genes(1).

87 y traits that are specific to different CHIP driver genes.

88 olecule compounds that target several cancer drivers has shown great therapeutic potential.

89 Older drivers have a crash rate nearly equal to that of young

90 subtypes, clarify novel somatic and germline drivers, highlight cellular origins and developmental hi

91 Ablation of AF drivers holds promise, but current technologies to ident

92 Gene duplication and divergence is a major driver in the emergence of evolutionary novelties.

93 vides further evidence that IgG is a primary driver in these autoantibody-mediated diseases.

94 e response and is thought to be an important driver in tumor immune evasion.

95 dentifying seasonal patterns of Al and their drivers in 16 rivers across Nova Scotia, Canada.

96 Systemic drivers in the contemporary structure of the science est

97 We identified novel recurrent MCL drivers, including CDKN1B, SAMHD1, BCOR, SYNE1, HNRNPH1,

98 ontext, and stress that identifying dominant drivers is crucial for designing efficient mitigation po

99 ood growth and its response to environmental drivers is limited.

100 global-scale patterns of K(S) and its major drivers is needed to achieve a better understanding of h

101 potential of ERBB2DeltaEx16 as a lung cancer driver, its expression transformed immortalized lung epi

102 the cell of origin rather than the acquired driver lesions.

103 ected germline recombination in distinct Cre driver lines designed for nervous system-specific recomb

104 Slight differences among Cre driver lines utilizing common transcriptional control el

105 ination in over half of 64 commonly used Cre driver lines, in most cases with a parental sex bias rel

106 cers, there is a need to identify additional driver mechanisms for genomic instability and targeted s

107 T cell responses and downstream anorexia as driver mechanisms of microbial dysbiosis after infection

108 es'), yet the same change is the most common driver mutation in melanoma.

109 ize that in both high- and low-risk LCH, the driver mutation is present in a BM-resident myeloid prog

110 e to DCs and LC-like cells in vitro, but the driver mutation was not easily detectable, likely due to

111 rrent smokers, at least 25% of cells carried driver mutations and 0-6% of cells had two or even three

112 er types show a positive association between driver mutations and aneuploidy, and a characteristic se

113 nfected T-cell clones carrying key oncogenic driver mutations can be detected in cases of ATL years b

114 odel for bacterial involvement in OSCC, with driver mutations generating a conducive microenvironment

115 KRAS is one of the most common driver mutations in human lung cancer and correlates wit

116 or a possible mechanistic link between early driver mutations in RAS and KIT and the widespread copy

117 cating an unexplored landscape of infrequent driver mutations in the non-coding genome.

118 The landscape of driver mutations in these tumors is dominated by mutatio

119 The influence of genetic background on driver mutations is well established; however, the mecha

120 ss the influence of the microenvironment and driver mutations on TPCs formation and function, the exi

121 , respectively, have "canonical" MPL exon 10 driver mutations W515L/K/R/A or S505N, which generate co

122 ions of abundant mutations, including cancer driver mutations, in histologically normal human tissues

123 btypes and exhibit a diverse set of putative driver mutations, thus providing a unique patient-derive

124 ia associated with acquisition of additional driver mutations.

125 fates when exposed to the appropriate set of driver mutations.

126 s in three cancer types with underlying BRAF driver mutations: melanoma, NSCLC, and ATC.

127 he transcription factor BMAL1 is a principal driver of a molecular clock in mammals.

128 Temperature was the main driver of adaptation, resulting in an increased thermoto

129 Although glycolysis is a main driver of allogeneic T cell-driven GVHD, oxidative phosp

130 y phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple

131 cy of erythropoietin production is the major driver of anemia in CKD, iron deficiency stands out amon

132 load rather than eye size appears to be the driver of anti-VEGF treatment duration and therefore, do

133 or for ZIKV replication and PML protein as a driver of anti-ZIKV intrinsic immunity.

134 loss of STAT3 O-GlcNAc at Threonine 717 as a driver of astrocyte differentiation.

135 Land-use change is a major driver of biodiversity loss worldwide.

136 Postacute care is a major driver of cardiac surgical episode spending, but the sou

137 These findings show that DZIP3 is a novel driver of cell-cycle and cancer progression via its cont

138 ic or landscape drivers, one often-forgotten driver of changes in flood properties is the variability

139 Dysregulation of Cdk1 is an early driver of cyst cell proliferation in ADPKD due to Pkd1 i

140 mmetric cell division, which is an important driver of development and cellular diversity.

141 the hypothesis that vessel noise level is a driver of disturbance, using humpback whales (Megaptera

142 ovleyi has recently been recognized as a key driver of DNRA in nature, but its enzymatic pathway is s

143 anscription factor NFE2L2/NRF2 as a critical driver of erythrophagocytes, and Nfe2l2/Nrf2 deficiency

144 Warming winter temperatures are a main driver of expansion of the native, evergreen shrub, More

145 e change, but could also be a non-negligible driver of future changes in biogeochemical cycles and cl

146 homeostasis, uncovering hyperglycinemia as a driver of HLD10 pathogenesis.

147 llomavirus (HPV) E7 oncoprotein is a primary driver of HPV-mediated carcinogenesis.

148 rely on ubiquitous CO(2) fertilization as a driver of increased carbon sinks in global forests.

149 Injury is a key driver of inflammation, a critical yet necessary respons

150 , suggesting surprise signalling as a shared driver of inhibitory and motivated control.

151 ons, implicating partial agonism as the main driver of its dissociative properties.

152 The SCAR/WAVE complex is the major driver of lamellipodia formation and cell migration down

153 Adhesions are the most common driver of long-term morbidity after abdominal surgery.

154 m' brain could be an additional, overlooked, driver of mammalian population densities.

155 Dispersal is now recognized as a driver of microbial diversity and function, but our unde

156 toperative myocardial injury remains a major driver of morbidity and mortality, the ability to accura

157 t and apoptosis, illuminating a new possible driver of myeloma cell evolution in a drug-resistant clo

158 A key driver of neutrophil recruitment and activation is the c

159 Oncogenic KRAS, a critical driver of pancreatic cancer, promotes metabolic reprogra

160 proposed to act as a potentially significant driver of pathogen-carrying mosquito species (disease ve

161 sease, and Porphyromonas gingivalis, a known driver of periodontitis, has been proposed as the microb

162 that inflammation is considered an important driver of postoperative delirium, next we tested whether

163 Ocean temperature was identified as a likely driver of productivity, with reduced NPP and standing st

164 mote differentiation towards beta-catenin, a driver of proliferation and colorectal tumorigenesis.

165 ive convergent genetic evolution to be a key driver of regulatory changes that lead to rapid phenotyp

166 It has been proposed that an important driver of resistance is selection imposed on bacterial p

167 g use-dependent, local sleep may be the main driver of response variability.

168 lighted the innate tendon environment as the driver of scarless healing.

169 tudes(2,3), hydroclimate may be the dominant driver of soil carbon persistence in the tropics(4,5); h

170 Phylogeny was a strong driver of species-specific microbial composition.

171 ibrosis in SSc skin, and can be an important driver of SSc pathogenesis.

172 the FHL2-GLI2 fusion is likely the oncogenic driver of SSTs, defining a genotypic-phenotypic correlat

173 n terrestrial N cycling and represents a key driver of terrestrial net primary productivity (NPP).

174 etic capacities in vascular plants and a key driver of the abrupt Cretaceous rise of the angiosperms.

175 ion and loss of natural habitat is the major driver of the current global biodiversity crisis.

176 se findings suggest that turgor is a central driver of the forest carbon sink and should be considere

177 constitutive activation of TFEB is the main driver of the kidney abnormalities and mTORC1 hyperactiv

178 of acute and terminal pain has been a major driver of the opioid crisis, together with the availabil

179 e in the Aleutian Low (a leading atmospheric driver of the PDO), and increasing correlation between t

180 ese results suggest that nitrogen is a major driver of the physiological ecology of E. huxleyi in thi

181 We find that the PA gene segment is a major driver of this phenotype and that both viral replication

182 ing following acute tendon injuries, but the driver of this regenerative healing response remains unk

183 nd not blood oxygen content that is the main driver of tissue oxygenation by RBCs.

184 petition has long been recognised as a major driver of trait divergence and adaptive evolution, relat

185 en GVHD, oxidative phosphorylation is a main driver of Treg suppressor function.

186 a surface temperature (SST) is a fundamental driver of tropical weather systems such as monsoon rainf

187 in KRAS-mutated colorectal cancer cells as a driver of tumor-stroma interactions that favor formation

188 the south tropical Indian Ocean is the main driver of year-to-year variability.

189 re of pathogens and xenobiotics as important drivers of adaptive evolution of mammals.

190 signaling interactions, and transcriptional drivers of all but the most highly polyploid cell types

191 d organoid and mouse models to determine the drivers of altered cholesterol metabolism in PDAC and th

192 ple with cancer, may have multiple molecular drivers of an otherwise common phenotype, and emphasize

193 are terms and is one of the most significant drivers of antimicrobial usage in dairy cattle.

194 rates provides no justification for ignoring drivers of any of these 3 types when projecting ecologic

195 The primary drivers of autophagy in states of nutrient and oxygen de

196 e first community-wide quantification of the drivers of bee phenology.

197 ponses to salient stimuli are among the main drivers of behavioral plasticity, yet, how animals evolv

198 of bonobos offer an ideal context to explore drivers of behavioural phenotypes, the essential investi

199 at long-term climate changes are the primary drivers of biodiversity change.

200 rest clearing but are increasingly important drivers of biomass loss.

201 nd that metastasis-private mutations are not drivers of cancer spread but instead associated with dru

202 Our results enhance our understanding of the drivers of carbapenem resistance in the Philippines, whi

203 Ral GTPases have been implicated as critical drivers of cell growth and metastasis in numerous Ras-dr

204 s; 2) multivariable analysis of quantitative drivers of change in linear growth; 3) interviews and fo

205 ls to study the socioeconomic and geographic drivers of CVE trends in Texas.

206 The identification of molecular drivers of disease and the compelling rise of biotherape

207 mpacts on our ability to elucidate molecular drivers of disease-associated dysbiosis across the micro

208 To explore drivers of dose-dependence and individual variation in i

209 soil biota and herbivores were the strongest drivers of exotic plant effects, particularly on measure

210 However, the temporal nature and drivers of functional adaptation remain undefined.

211 e fire and soil C : N ratio were the primary drivers of fungal composition in the Oe and A1/A2 horizo

212 life, strongly implicating them as important drivers of global biogeochemical cycles.

213 teractions of its members determine when key drivers of health occur, for how long they last, and how

214 and glial family ligands (GFLs) as potential drivers of hematopoietic survival and self-renewal in th

215 pers our ability to understand the molecular drivers of henipavirus emergence.

216 We explore multiple drivers of heterogeneous vulnerability across the distri

217 room use and anesthesia services were major drivers of higher cost, with 407% (95% confidence interv

218 an annual temperature were the main climatic drivers of higher decomposition rates, while biochemical

219 Key drivers of hyperinflammation induced by fungal cell wall

220 ppaB family of transcription factors are key drivers of inflammation that activate sets of genes in r

221 y hypothesised environmental and virological drivers of influenza epidemics.

222 Metabolism is one of the strongest drivers of interkingdom interactions-including those bet

223 Our study provides critical insight into drivers of key flowering phenophases and confirms that H

224 bolism is critical for elucidating metabolic drivers of larger phenotypes and disease.

225 Experimental studies investigating the drivers of LLPS have shown that intrinsically disordered

226 decadal timescales, the emergence of natural drivers of loss presents an immediate challenge for coas

227 s, IMPAD1 and KDELR2, as robust, independent drivers of lung cancer invasion and metastasis.

228 Here we review the most relevant proximate drivers of masting and outline a research agenda that ta

229 will come from identifying the developmental drivers of maturation and leveraging them to create more

230 resource for another, constitute the central drivers of microbial community assembly.

231 ession intensity-related measures were major drivers of mortality.

232 hesizes the available global evidence on the drivers of national declines in stunting prevalence and

233 Disentangling the drivers of natural selection within such communities is

234 ean surface buoyancy suppresses two physical drivers of nutrient supply: vertical mixing and meridion

235 mutations or fusions are all now known to be drivers of oncogenesis.

236 a concomitant increase in 2 transcriptional drivers of oxidative metabolism, PGC1alpha and PPARD, su

237 Here, we present an expert assessment of the drivers of potential alien species impacts under contras

238 Rates and drivers of primary productivity are well understood for

239 f terrestrial non-volant mammals to identify drivers of recent contraction and expansion in their ran

240 TI) carbohydrate antigens (Ags) are critical drivers of rejection reactions to ABO-incompatible allog

241 0) to shed light on environmental and social drivers of seamount association around New Caledonia in

242 pport the hypothesis that NETs may represent drivers of severe pulmonary complications of COVID-19 an

243 s been directed toward adult sex hormones as drivers of sex differences, that female sex bias in MC-a

244 cture raise questions about the evolutionary drivers of sleep behavior.

245 (i.e. tree-species-specific characteristics) drivers of slope parameter variation.

246 aceutical interventions, to assess potential drivers of spatiotemporal spread, and to support contact

247 t into the elusive functional and structural drivers of STM bacteria.

248 ce and compares the relative effect of major drivers of stunting decline between countries.

249 food security, and maternal nutrition as key drivers of stunting decline.

250 ason when little is known about the physical drivers of such events.

251 The abnormal immune cells may be the drivers of systemic abnormalities such as autoimmune dis

252 irds and managed to pinpoint key aspects and drivers of tagging effects.

253 Yet, we are only beginning to grasp the drivers of terrestrial microbial diversity and biogeogra

254 Earlier research has detected important drivers of the change in plant functional traits under w

255 to the genetic basis, as well as mechanistic drivers of the disease and possible treatment options.

256 ndently control potential abiotic and biotic drivers of the F(soil)-T hysteresis.

257 The two dominant drivers of the global mean sea level (GMSL) variability

258 nical Gli1 activity, but characteristics and drivers of the nMRTF cell state remain unknown.

259 ncer initiation and progression, but the key drivers of these pathways are just being discovered.

260 as a results of serotype switching, but the drivers of these patterns are not well understood.

261 e, and to examine the proximate and ultimate drivers of this behaviour.

262 Understanding the drivers of this bottleneck is crucial to developing effe

263 The genetic drivers of this cancer have not been firmly established,

264 an essential first step to understanding the drivers of this variation and, ultimately, predicting th

265 standing the different roles played by these drivers of variability is fundamental to predicting near

266 However, the patterns and underlying drivers of variation in dispersal across species remain

267 AS in Ontario, Canada, and to understand the drivers of wait-list mortality and hospitalization due t

268 lakes across the world to examine trends and drivers of whole-lake vertical thermal structure.

269 ve been proposed as indicators, and possibly drivers, of ventilator-induced lung injury.

270 ntaining numerous gamete (spore)-killing wtf drivers, offers a tractable system to test this hypothes

271 information about the integrated effects of drivers on all demographic rates provides no justificati

272 of top-down, bottom-up and density-dependent drivers on cheetah survival and reproduction.

273 Cluster Region-Abelson kinase (BCR-Abl) is a driver oncogene that causes chronic myeloid leukemia and

274 buted to a range of atmospheric or landscape drivers, one often-forgotten driver of changes in flood

275 that two of the most pervasive global change drivers operate via different pathways when decreasing s

276 ssification of electrograms recordings as AF driver or nondriver compared with the NIOM gold-standard

277 From an external driver perspective policy, guidance and research are ess

278 unique genomic landscape shaped by oncogenic drivers promotes immune suppression from the earliest st

279 Identification of genetic drivers promoting dissemination of tumor cells may provi

280 esenchyme, using the Osr2(Cre) and Col2(Cre) drivers, respectively, which resulted in palatal shelf e

281 We studied the driver's neural and motor patterns while he drove a spor

282 e and precipitation appeared to be important drivers shaping peatland community and surface moisture

283 Natural drivers such as large explosive volcanic eruptions or mu

284 may be non-random and influenced by external drivers, such as climate, soil conditions or land use.

285 on of the underlying factors (referred to as drivers) that prevent the achievement of cure in RA by t

286 logical challenges would have been important drivers throughout human evolution.

287 gross primary productivity and environmental drivers to constrain source contributions.

288 eins whose activities are affected by cancer drivers to proteins that impact on the 'hallmarks of can

289 entistry and offers perspectives on managing drivers to reduce carbon emissions and make dentistry mo

290 Governments can nudge PHEV drivers toward environmentally favorable fueling behavio

291 common to epithelial-mesenchymal transition driver transcription factors in stem cell-specific acces

292 Small changes in the RT rate or set of driver tumor-suppressor genes (TSGs) were observed to al

293 ic home range analysis (MHRA) to uncover the drivers underlying home range patterns in a passerine th

294 vivo screening platform and discover several driver variants of PIK3CA.

295 We found that black drivers were less likely to be stopped after sunset, whe

296 e a crash rate nearly equal to that of young drivers whose crash rate is the highest among all age gr

297 Climate drivers will alter deep-sea biodiversity and associated

298 72 tumor exomes found known and novel cancer drivers with high tissue-specificities.

299 ways are presented configuring early primary drivers with subsequent adiposity, insulin resistance, b

300 t effects and effects mediated through other drivers, would allow us to better predict population fat